KR20190139053A - A drug for treating shoulder periarthritis and its preparation method - Google Patents

Abstract

The present invention discloses a medicine for treating shoulder periarthritis and a method for manufacturing the same. The medicine for treating shoulder periarthritis contains: 5 to 18 parts by weight of Glechoma hederacea; 10 to 25 parts by weight of Lygodium japonicum; 13 to 20 parts by weight of Houttuynia cordata; 12 to 20 parts by weight of earthworms; and 5 to 15 parts by weight of Angelica gigas. The medicine for treating shoulder periarthritis according to the present invention has a different configuration compared to existing medicines, and can overcome the deficiencies of existing medicines.

Description

A drug for treating shoulder periarthritis and its preparation method

TECHNICAL FIELD The present invention relates to the field of drugs, and more particularly, to a drug for treating periarthritis of the shoulder and a preparation method thereof.

Periarthritis of the shoulder is chronic, aseptic inflammation of the soft tissues such as muscles, tendons, bursa, and articular capsules around the shoulder joint. Inflammation causes adhesions inside and outside the joints that affect the activity of the shoulder joints. Shoulder arthroscopic lesions are characterized by a wide range of pain, a wide range of functional limitations, and a wide range of tenderness. The full name of the dog is called scapula periarthritis. In traditional Chinese medicine, it is believed to be a chronic disease caused by invasion of tendons and blood vessels around the shoulders. Due to reiki and gastric insufficiency and weakening of the bones and muscles of the human body, foreign pathogenic factors penetrate and damage tendons and blood vessels around the shoulder, causing pain due to blockage of the Gi and blood.

Currently, the treatment of periarthritis shoulder shoulders has a mild alleviating effect, but has weak targets, long treatment cycles and major side effects. Thus, there is an urgent need for new drugs for the treatment of periarthritis of the shoulder to overcome these deficiencies.

Korean Registered Patent No. 15104940000

In view of the above problem, the present invention provides a shoulder arthritis therapeutic drug that can solve the problems or at least some of the problems, which is used to overcome the deficiencies of the poor therapeutic effect of conventional drugs.

According to the first aspect, the present invention is for the treatment of periarthritis of the shoulder, including 5 to 18 parts by weight, 10 to 25 parts by weight of fern, 13 to 20 parts by weight, worms 12 to 20 parts by weight, and 5 to 15 parts by weight of Angelica. Provide medication.

According to a second aspect, the invention provides a process for the manufacture of a medicament according to any one of the above embodiments, comprising the following steps:

As a first step, 5 to 18 parts by weight of Geumchocho, 10 to 25 parts by weight of silly fern, 13 to 20 parts by weight of weak hair, 12 to 20 parts by weight of earthworms, and 5 to 15 parts by weight of donkey

In a second step, grinding the raw materials to obtain a powder mixture;

In a third step, the mixture is immersed in water for 0.5 to 1 hour and then the resultant is decanted for 30 minutes on a high heat to obtain a decoction;

As a fourth step, after cooling the medicament and filtered through a 100 to 250 mesh filter cloth to obtain a filtrate, the filtrate is concentrated to obtain a thick paste of 1.2 to 1.25 density;

As a fifth step, after drying the thick paste, the dried product is ground and sieved to obtain a target drug.

The present invention discloses a drug for the treatment of periarthritis of the shoulder and a method of manufacturing the same. The shoulder arthritis therapeutic drug according to the present invention has a different configuration from the conventional drugs, and can overcome the deficiencies of the conventional drugs.

1. Drugs for the treatment of periarthritis of the shoulder, including 5 to 18 parts by weight of Geumchocho, 10 to 25 parts by weight of fern, 13 to 20 parts by weight of weak hair, 12 to 20 parts by weight of earthworm, and 5 to 15 parts by weight of Angelica

2. in the above 1,

The drug is a drug for the treatment of periarthritis of the shoulder further comprising 20 to 30 parts by weight gastric gland

3. In the above 1,

The drug is a drug for the treatment of periarthritis of the shoulder further comprising 12 to 18 parts by weight of the upper limbs

4. In the above 1,

The drug may be in the form of at least one of film coated tablets, sugar coated tablets, enteric coated tablets, dispersible tablets, capsules, granules, medicinal preparations, mixtures, syrups, medicinal wines, injectables, oral solutions and oral suspensions. Drugs for the treatment of periarthritis of the shoulder

5. Method of preparing a drug of any one of the above 1 to 4, comprising the following steps:

As a first step, 5 to 18 parts by weight of Geumchocho, 10 to 25 parts by weight of silcho, 13 to 20 parts by weight of weak hair, 12 to 20 parts by weight of earthworm, 5 to 15 parts by weight of donkey;

In a second step, grinding the raw materials to obtain a powder mixture;

In a third step, the mixture is immersed in water for 0.5 to 1 hour and then the resultant is decanted for 30 minutes on a high heat to obtain a decoction;

As a fourth step, after cooling the medicament and filtered through a 100 to 250 mesh filter cloth to obtain a filtrate, the filtrate is concentrated to obtain a thick paste of 1.2 to 1.25 density;

As a fifth step, after drying the thick paste, the dried product is ground and sieved to obtain a target drug.

The present invention discloses a drug for the treatment of periarthritis of the shoulder and a method of manufacturing the same. The shoulder arthritis therapeutic drug according to the present invention has a different configuration from the conventional drugs, and can overcome the deficiencies of the conventional drugs.

One embodiment of the present invention is 5 to 18 parts by weight of Lysimachia christinae hance, 10 to 25 parts by weight of Lygodium japonicum, 13 to 20 parts by weight of Houttuynia cordata, 12 to 20 parts by weight of worms (Lumbricus) And Angelica sinensis provides a drug for treating shoulder periarthritis comprising 5 to 15 parts by weight.

In addition, the drug further comprises 20 to 30 parts by weight of the gastrointestinal (Radix Clematidis).

In addition, the drug further comprises 12 to 18 parts by weight of the upper limb (Ramulus Mori).

The above lieutenant stomach and upper limbs are only some specific examples and are not intended to be limited thereto. Other materials are also possible, such as Fructus ligustri lucidi. Other possible materials will not be described in detail.

Optionally, in one embodiment of the present invention, materials for vitalization of blood circulation, such as Carcuma longa and Evening primrose, may be added.

In addition, in one embodiment of the present invention, the drug is to improve the pharmacological effects of the drug (Houttuynia cordata), Semen cassiae, Cortex fraxini, Radix sophorae flavescentis, Flos chrysanthemi indici And it may further include a material for removing heat, such as Andrographis paniculata.

In addition, the drug may further include a material that removes moisture and promotes diuresis, such as Herba sedi and Abrus herb.

In addition, the drug may further include a material that warms the inside, such as pepper.

In one embodiment of the invention, the formulation of the drug is in film coated tablets, sugar coated tablets, enteric coated tablets, dispersible tablets, capsules, granules, decoctions, mixtures, syrups, medicinal wines, injectables, oral solutions and oral suspensions. At least one.

In one embodiment of the invention, optionally, the drug has an oral dosage form.

In one embodiment of the invention, optionally, the oral dosage form comprises tablets, capsules, pills, injections, sustained release formulations and controlled release formulations.

The drug according to an embodiment of the present invention or a pharmaceutical composition containing the same may be administered in unit dosage form through the intestine, nasal cavity, oral mucosa, eyes, lungs, respiratory system, skin and rectum, oral administration, intravenous injection, It can be administered by intramuscular injection and subcutaneous injection.

Dosage formulations may be liquid, solid or semisolid formulations. Liquid formulations may be solutions, emulsions, suspensions, infusions (including water infusions, powder infusions, transfusions), eye drops, nasal drops, lotions, and stains; Solid dosage forms include tablets (including uncoated tablets, enteric coated tablets, oral tablets, dispersible tablets, chewable tablets, effervescent tablets and orally disintegrating tablets), capsules (including hard capsules, soft capsules and enteric capsules), Formulations such as granules, powders, pellets, drop pills, suppositories, film formulations, pastes, aerosols and sprays; Semi-solid formulations may be formulations such as ointments, gels and pastes. The formulation of the drug is preferably tablets, capsules, pills and injections.

Drugs according to one embodiment of the present invention may be prepared in conventional manufacturing methods, sustained release formulations, controlled release formulations, targeting formulations and various granule dosage formulations.

According to one embodiment of the present invention, various excipients such as diluents, binders, moisturizers, disintegrants, lubricants and lubricants may be used to prepare the drug of the present invention in tablet form. Diluents can be starch, dextrin, sucrose, glucose, lactose, mannitol, sorbitol, xylitol, microcrystalline cellulose, calcium sulfate, calcium hydrogen phosphate, calcium carbonate and the like; Humectants may be water, ethanol, isopropanol, and the like; The binder may be starch pulp, dextrin, syrup, honey, glucose solution, microcrystalline cellulose, gum arabic pulp, gelatin pulp, sodium carboxymethyl cellulose and methyl cellulose; Disintegrants can be dry starch, microcrystalline cellulose, low substituted hydroxypropylcellulose; Lubricants and lubricants may be talc, silica, stearate, liquid paraffin, and the like.

The drug may also be a coated tablet, for example, a sugar coated tablet, a film coated tablet, an enteric coated tablet, or the like.

When the drug is prepared in capsules, the active ingredient may be prepared in granules or pellets by the addition of diluents, binders and disintegrants, which are placed in hard capsules or soft capsules.

When the drug is prepared as an injection, the solvent may be prepared from water, ethanol, isopropanol, propylene glycol or mixtures thereof. In addition, an appropriate amount of dissolution aid, cosolvent, pH adjuster and osmotic pressure adjuster may be added.

The drug may also be added with colorants, preservatives, perfumes, correctors and other additives.

According to one embodiment of the invention, there is provided a method of preparing the drug comprising the following steps.

As a first step, 5 to 18 parts by weight of Geumchocho, 10 to 25 parts by weight of silcho, 13 to 20 parts by weight of weak hair, 12 to 20 parts by weight of earthworm, 5 to 15 parts by weight of donkey;

In a second step, grinding the raw materials to obtain a powder mixture;

In a third step, the mixture is immersed in water for 0.5 to 1 hour and then the resultant is decanted for 30 minutes on a high heat to obtain a decoction;

As a fourth step, after cooling the medicament and filtered through a 100 to 250 mesh filter cloth to obtain a filtrate, the filtrate is concentrated to obtain a thick paste of 1.2 to 1.25 density;

As a fifth step, after drying the thick paste, the dried product is ground and sieved to obtain a target drug.

Hereinafter, some specific examples of a method for preparing a drug for treating shoulder periarthritis are presented.

Example  One

As a first step, 5 to 18 parts by weight of Geumchocho, 10 to 25 parts by weight of silcho, 13 to 20 parts by weight of weak hair, 12 to 20 parts by weight of earthworm, 5 to 15 parts by weight of donkey;

In a second step, each of the raw materials are ground and mixed to obtain a mixture, and the resultant is immersed in water for 0.5 to 1 hour and then the resultant is decocted at 50 ° C. for 30 minutes to obtain decoction;

As a third step, cooling the medicament for 5 hours, filtered through a filter cloth of 100 to 150 mesh to obtain a filtrate, and then concentrated the filtrate to obtain a thick paste of 1.2 to 1.25 density;

As a fourth step, the thick paste is dried, and the dried product is pulverized and sieved to obtain a target drug.

Example  2

As a first step, weighing 15 parts by weight of Geumchocho, 10 parts by weight of silgori, 13 parts by weight of weak hair, 18 parts by weight of earthworm, 20 parts by weight of the stomach line, and 12 parts by weight of Angelica;

As a second step, each of the raw materials are ground into fine powder and screened with a 100 mesh sieve;

As a third step, the screened raw materials to the moon for 30 minutes with water at 30 ℃, continued for 12 hours at room temperature to obtain a decoction;

As a fourth step, filtering the medicament with a filter cloth of 100 to 250 mesh to obtain a filtrate, the filtrate is concentrated to obtain a thick paste;

As a fifth step, drying the thick paste, pulverizing the dried resultant, and sieving to obtain the target drug.

Example  3

As a first step, weighing 15 parts by weight of Geumjeoncho, 10 parts by weight of silgori, 18 parts by weight of wormwood, 18 parts by weight of earthworms, 30 parts by weight of the lieutenant stomach, 15 parts by weight of the upper limbs and 12 parts by weight of the donkey;

In a second step, mixing the raw materials to obtain a mixture, immersing the mixture in water, and then weighing the resultant to obtain a decoction;

As a third step, after cooling the medicament and filtered through a filter cloth of 100 to 250 mesh to obtain a filtrate, the filtrate is concentrated to obtain a thick paste of 1.2 to 1.25 density;

In a fourth step, the thick paste is mixed with three times the amount of dextrin to prepare a soft material, and is made into granules using a vibrating granulator to obtain granules;

As a fifth step, the granules were dried at 65 ° C. for 30 minutes, granulated straightening was performed, and then screened to remove small granules and packaged.

Example  4

As a first step, weighing 15 parts by weight of Geumjeoncho, 10 parts by weight of silgori, 18 parts by weight of wormwood, 18 parts by weight of earthworms, 30 parts by weight of the lieutenant stomach, 15 parts by weight of the upper limbs and 12 parts by weight of Angelica

In a second step, mixing the raw materials to obtain a mixture, immersing the mixture in water, and then weighing the resultant to obtain a decoction;

As a third step, after cooling the medicament and filtered through a filter cloth of 100 to 250 mesh to obtain a filtrate, the filtrate is concentrated to obtain a thick paste of 1.2 to 1.25 density;

In a fourth step, the thick paste is mixed with three times the amount of dextrin to prepare a soft material, and is made into granules using a vibrating granulator to obtain granules;

As a fifth step, the granules were dried at 65 ° C. for 30 minutes and granulated straightening, followed by tableting with a single-stage tablet to obtain 0.3 g of tablets.

The shoulder arthritis therapeutic drug according to the present invention has a different configuration from the conventional drugs, and can overcome the deficiencies of the conventional drugs.

Claims (5)

Drugs for the treatment of periarthritis of the shoulder, including 5 to 18 parts by weight, 10 to 25 parts by weight of fern, 13 to 20 parts by weight, worms 12 to 20 parts by weight, and 5 to 15 parts by weight of Angelica
The method according to claim 1,
The drug is a drug for the treatment of periarthritis of the shoulder further comprising 20 to 30 parts by weight gastric gland
The method according to claim 1,
The drug is a drug for the treatment of periarthritis of the shoulder further comprising 12 to 18 parts by weight of the upper limbs
The method according to claim 1,
The drug may be in the form of at least one of film-coated tablets, sugar-coated tablets, enteric coated tablets, dispersible tablets, capsules, granules, decoctions, mixtures, syrups, medicinal wines, injectables, oral solutions and oral suspensions. Drugs for the treatment of periarthritis of the shoulder
A method of preparing a medicament according to any one of claims 1 to 4, comprising the following steps:
As a first step, 5 to 18 parts by weight of Geumchocho, 10 to 25 parts by weight of silcho, 13 to 20 parts by weight of weak hair, 12 to 20 parts by weight of earthworm, 5 to 15 parts by weight of donkey;
In a second step, grinding the raw materials to obtain a powder mixture;
In a third step, the mixture is immersed in water for 0.5 to 1 hour and then the resultant is weighed for 30 minutes on a high heat to obtain a medicinal solution;
As a fourth step, after the coolant is cooled to obtain a filtrate with a 100 to 250 mesh filter cloth, the filtrate is concentrated to obtain a thick paste of 1.2 to 1.25 density;
As a fifth step, after drying the thick paste, the dried product is ground and sieved to obtain a target drug.