KR20190131926A - A drug for treating cold and its preparation method - Google Patents

Abstract

The present invention discloses a medicine for treating cold and a method for manufacturing the same. The medicine for treating cold contains: 10 to 20 parts by weight of Lycium barbarum; 10 to 15 parts by weight of Artemisia argyi; and 3 to 20 parts by weight of Forsythia viridissima. The medicine for treating cold according to the present invention has different components from existing medicines and can overcome shortcomings of existing medicines.

Description

A drug for treating cold and its preparation method

FIELD OF THE INVENTION The present invention relates to the field of medicine, in particular to medicines for the treatment of colds and methods for their preparation.

Cold is the most common acute respiratory infectious disease, but if you look at domestic or international data, it can be a serious social and economic burden, can cause serious complications, and can even endanger your life. It is not normal.

Currently, colds are treated with rational diets, adequate amounts of exercise, restrictions on smoking cessation and alcohol consumption, and psychological balance or medication, but the therapeutic effect is not ideal. In addition, current medications have other toxicities and side effects. Therefore, there is an urgent need for a new medicine for the treatment of colds to overcome the above drawbacks.

Korean Patent No. 0185538

In view of the above problems, the present invention provides a medicine for treating colds which can solve the above problems or at least part of the above problems, and can overcome the drawback of the poor therapeutic effect of conventional medicines.

According to a first aspect, the present invention provides a medicament for treating colds comprising 10 to 20 parts by weight of Cortex lycii radicis, 10 to 15 parts by weight of Folium artemisiae argyi and 3 to 20 parts by weight of Fructus forsythia. to provide.

According to a second aspect, the present invention provides a method of preparing a medicament according to any one of the above embodiments, comprising the following steps.

First step: 10 to 20 parts by weight of Cortex lycii radicis, 10 to 15 parts by weight of follum artemisiae argyi and 3 to 20 parts by weight of Fructus forsythia;

Second step: decoction of the raw materials to obtain a Chinese medicine, cooking the Chinese medicine for 30 to 60 minutes in a pressure cooker for sterilization;

Third step: cooling the resultant, filtering with 100-250 mesh filter cloth, and concentrating to obtain a thick paste;

Fourth step: The thick paste is dried, pulverized and sieved to obtain a desired medicine.

The present invention discloses a medicine for treating colds and a method of manufacturing the same. The medicine for treating colds according to the present invention has a different ingredient from the conventional medicines and can overcome the drawbacks of the conventional medicines.

Hereinafter, the present invention will be described in detail.

In one embodiment of the present invention, 10 to 20 parts by weight of Cortex lycii radicis, 10 to 15 parts by weight of Folium artemisiae argyi and 3 to 20 parts by weight of Fructus forsythia are provided. do.

In addition, the medicine may further comprise 20 to 50 parts by weight of ginger (fresh ginger).

In addition, the medicine may further comprise 2 to 22 parts by weight of Agastache rugosus.

The fresh ginger and Agastache rugosus are not limited to these specific examples, but are not limited thereto. Wolfberry fruit, Gynostemma pentaphyllum, Semen Astragali Complanati, Radix Dipsaci, Other materials are also possible, such as Herba Eclipta and Fructus Ligustri Lucidi. Other possible materials are not described in detail.

Optionally, in an embodiment of the present invention, materials for aiding blood circulation, such as Curcuma longa, Ligusticum chuanxiong Hort, Radix Salviae Miltiorrhizae, Evening Primrose, may be further included.

In addition, in one embodiment of the present invention, in order to enhance the pharmacological effect, the medicament is Gardenia (Fructus Gardeniae), Chrysanthemum (Flos Chrysanthemi), Semen Cassiae, Cortex Fraxini, Radix Sophorae Flavescentis And it may further include materials for antipyretic, such as (Flos Chrysanthemi Indici), Andrographis paniculata.

In addition, the medicament may further include materials that eliminate moist energy (hum), such as Herba Sedi, Abrus Herb, and the like, and promote diuretic action.

In addition, the medicament may further comprise materials that warm the interior, such as pepper.

In one embodiment of the present invention, the pharmaceutical formulation is a film-coated tablet (sugar-coated tablet), sugar coated tablet (sugar coated tablet), enteric coated tablet (enteric coated tablet), dispersible tablet, capsule, granules At least one of, medicinal herbs, mixtures, syrups, medicinal wines, injectables, oral solutions and oral turbid liquids.

In one embodiment of the invention, optionally, the medicament has an oral dosage form.

In one embodiment of the invention, optionally, the oral dosage form comprises tablets, capsules, pills, injections, sustained release preparations and controlled release preparations.

The medicament or pharmaceutical composition of the embodiments provided in the present invention may be administered in unit dosage form through the intestine, nasal cavity, oral mucosa, eyes, lungs, respiratory system, skin, rectum, and the like, oral administration, intravenous injection, intramuscular injection and subcutaneous injection. It can be administered by.

Dosage formulations may be liquid, solid or semisolid formulations. The liquid formulations may be solutions, emulsions, suspensions, injections (including water injections, powder injections and transfusions), eye drops, nasal drops, lotions and applicators; Such solid formulations include tablets (uncoated tablets, enteric tablets, buccal tablets, dispersible tablets, chewable tablets, effervescent tablets, orally disintegrating tablets). ), Capsules (including hard capsules, soft capsules, enteric capsules), granules, powders, pellets, dropping pills, suppositories, film agents, May be paste, aerosol, spray, or the like; The semisolid formulation may be an ointment, a gel, a paste, or the like. The formulation of the medicament is preferably tablets, capsules, pills and injections.

The medicament according to one embodiment of the present invention may be prepared from traditional formulations, sustained release formulations, controlled release formulations, targeted formulations and various granular formulations.

In one embodiment of the invention, diluents, binders, humectants, disintegrating agents, lubricants and glidants for the preparation of the medicaments of the invention into tablets Various excipients such as can be used. The diluent may be starch, dextrin, fructose, glucose, lactose, mannitol, sorbitol, xylitol, microcrystalline cellulose, calcium sulfate, calcium hydrogen phosphate, calcium carbonate and the like; The wetting agent may be water, ethanol, isopropanol and the like; The binder may be starch pulp, dextrin, syrup, honey, glucose solution, microcrystalline cellulose, gum arabic pulp, gelatin pulp, carboxymethyl sodium cellulose or methyl cellulose; The disintegrant may be dried starch, microcrystalline cellulose, low substituted hydroxypropyl cellulose; The lubricant and lubricant may be talc, silica, stearate, liquid paraffin, or the like.

Furthermore, the medicine may be a coated tablet, for example, may be a sugar coating, a film coating, a long coat, and the like.

If the medicament is prepared in capsules, the active ingredient may be prepared in the form of granules or pellets with added diluents, binders and disintegrants, which are located in hard capsules or soft capsules.

When the medicament is prepared as an injection, the solvent may be water, ethanol, isopropanol, propylene glycol, or mixtures thereof. Furthermore, appropriate amounts of solubilizers, cosolvents, pH adjusters, osmotic pressure modifiers may be added.

In addition, colorants, presevatives, perfumes, corrigents or other additives may be added to the medicament.

In one embodiment of the present invention, there is provided a method of preparing the medicament comprising the following steps.

First step: 10 to 20 parts by weight of Cortex lycii radicis, 10 to 15 parts by weight of follum artemisiae argyi and 3 to 20 parts by weight of Fructus forsythia;

Second step: decoction of the raw materials to obtain a Chinese medicine, cooking the Chinese medicine for 30 to 60 minutes in a pressure cooker for sterilization;

Third step: cooling the resultant, filtering with 100-250 mesh filter cloth, and concentrating to obtain a thick paste;

Fourth step: drying, grinding and sieving the thick paste to obtain the desired medicine.

Hereinafter, some specific examples of the manufacturing method of the medicine for cold treatment are provided.

Example

Example  One

First step: weighing 10 to 20 parts by weight of Cortex lycii radicis, 10 to 15 parts by weight of Folium artemisiae argyi and 3 to 20 parts by weight of Fructus forsythia and mixing them to obtain a mixture;

Second step: adding an appropriate amount of water to the mixture of Cortex lycii radicis, Folium artemisiae argyi and Fructus forsythia, and soaking for 8 hours until it is sufficiently wetted;

Step 3: adding 20 g of ginger to the mixture, heating at 30 ° C. for 4 hours, and adding 10 ml of water every 30 minutes;

Fourth step: heating the mixture for 4 hours, leaving at room temperature for 12 hours;

Step 5: filtering the mixture through a 100 to 250 mesh filter cloth and concentrating the resultant to obtain a thick paste;

6th step: The said thick paste is dried, pulverized and sieved to obtain a desired medicine.

Example  2

First step: weighing Agastache rugosus, Cortex lycii radicis, Folium artemisiae argyi, and Fructus forsythia, and mixing them to obtain a mixture;

Step 2: Add an appropriate amount of water to the mixture of Agastache rugosus, Cortex lycii radicis, Folium artemisiae argyi, and Fructus forsythia, for at least 8 hours until it is sufficiently wetted. Dipping;

Step 3: After adding 20 g of Semen Armeniacae Amarum to the mixture, heating at 30 ° C. for 4 hours, and adding 10 ml of water every 30 minutes;

Fourth step: heating the mixture for 4 hours, leaving at room temperature for 12 hours;

Step 5: filtering the mixture through a 100 to 250 mesh filter cloth and concentrating the resultant to obtain a thick paste;

6th step: The said thick paste is dried, pulverized and sieved to obtain a desired medicine.

Example  3 (Manufacturing Method of Granules)

First step: weighing Agastache rugosus, Cortex lycii radicis, Folium artemisiae argyi, and Fructus forsythia, and mixing them to obtain a mixture;

Step 2: Add an appropriate amount of water to the mixture of Agastache rugosus, Cortex lycii radicis, Folium artemisiae argyi, and Fructus forsythia, for at least 8 hours until it is sufficiently wetted. Dipping;

Step 3: adding 20 g of Semen Armeniacae Amarum to the mixture, heating at 30 ° C. for 4 hours, and adding 10 ml of water every 30 minutes;

Fourth step: heating the mixture for 4 hours, leaving at room temperature for 12 hours;

Step 5: The mixture was filtered to obtain a filtrate, and the filtrate was concentrated under reduced pressure at a relative density of 1.25 (60 ° C.) to obtain an extract, and the extract was mixed with 3 times the amount of dextrin to obtain a soft substance. Preparing granules with a machine;

Step 6: Drying the granules at 65 ° C. for 30 minutes, trimming the granules, sieving to remove small granules, and then packing.

Example  4 (Production method of the tablet)

First step: weighing 10 to 20 parts by weight of Cortex lycii radicis, 10 to 15 parts by weight of Folium artemisiae argyi and 3 to 20 parts by weight of Fructus forsythia and mixing them to obtain a mixture;

Second step: adding an appropriate amount of water to the mixture of Cortex lycii radicis, Folium artemisiae argyi and Fructus forsythia, and soaking for 8 hours until it is sufficiently wetted;

Step 3: adding 20 g of Rhizoma Dioscoreae to the mixture, heating at 30 ° C. for 4 hours, and adding 10 ml of water every 30 minutes;

Fourth step: heating the mixture for 4 hours, leaving at room temperature for 12 hours;

Step 5: The mixture was filtered to obtain a filtrate, and the filtrate was concentrated under reduced pressure at a relative density of 1.25 (60 ° C.) to obtain an extract, and the extract was mixed with 3 times the amount of dextrin to obtain a soft substance. Preparing granules with a machine;

Step 6: drying the granules at 65 ° C. for 30 minutes to obtain 0.3 g of tablets using a single-punch tablet press.

The medicine of the present invention may be administered independently or may be used with other therapeutic medicines. If there is a synergy between the drug of the present invention and another therapeutic drug, the dosage of the drug of the present invention can be adjusted as necessary. The above embodiments are for illustrative purposes only and are not intended to be limiting.

Example  5

First step: carefully selecting Cortex lycii radicis, Folium artemisiae argyi, and Fructus forsythia, washing, weighing according to a specific ratio, and mixing uniformly to obtain starting material;

Step 2: After adding the starting material to purified water, the resultant is cooked in a steam pressure cooker for 3 to 4 times for 40 to 80 minutes at a time, extracting thick paste at every cooking, and thick paste 100 to 250 Filtering with mesh filter cloth;

Step 3: uniformly mixing all the thick pastes;

Fourth step: Drying, grinding and sieving the uniformly mixed thick pastes to obtain the desired medicine.

Claims (5)

A medicament for treating colds comprising 10 to 20 parts by weight of Cortex lycii radicis, 10 to 15 parts by weight of Folium artemisiae argyi, and 3 to 20 parts by weight of Fructus forsythia.
The medicine for treating colds according to claim 1, further comprising 20 to 50 parts by weight of fresh ginger.
The medicament for treating colds according to claim 1, further comprising 2 to 22 parts by weight of Agastache rugosus.
The method of claim 1, wherein the dosage form of the medicament is at least one of a film coated tablets, sugar coated tablets, long tablets, dispersion tablets, capsules, granules, decoctions, mixtures, syrups, medicinal wines, injections, oral solutions and oral suspensions Medicine for the treatment of colds.
A method of preparing a medicament according to any one of claims 1 to 4, comprising the following steps:
First step: 10 to 20 parts by weight of Cortex lycii radicis, 10 to 15 parts by weight of follum artemisiae argyi and 3 to 20 parts by weight of Fructus forsythia;
Second step: decoction of the raw materials to obtain a Chinese medicine, cooking the Chinese medicine for 30 to 60 minutes in a pressure cooker for sterilization;
Third step: cooling the resultant, filtering with 100-250 mesh filter cloth, and concentrating to obtain a thick paste;
Fourth step: The thick paste is dried, pulverized and sieved to obtain a desired medicine.