KR20190120879A - A drug for treating cold and its preparation method - Google Patents

Abstract

The present invention relates to a medicine for treating cold and a method for manufacturing the same. The medicine for treating cold contains: 10 to 20 parts by weight of Forsythia koreana; 10 to 15 parts by weight of Perilla frutescens leaves; and 3 to 20 parts by weight of Taraxacum platycarpum. The medicine for treating cold according to the present invention has different components compared to medicines in the prior art, and can overcome deficiencies of medicines in the prior art.

Description

Drug for the treatment of colds and preparation method thereof {A DRUG FOR TREATING COLD AND ITS PREPARATION METHOD}

The present invention relates to the field of drugs, in particular drugs for the treatment of colds and methods for their preparation.

Colds are the most common acute respiratory infectious disease, but common colds are not really "common", and domestic and international data suggest that these common colds can cause serious social and economic burdens and can cause serious complications. And even threaten the patient's life.

Currently, colds are treated with reasonable diet, adequate exercise, smoking cessation, and limited amounts of alcohol and psychological balance or medication, but the therapeutic effect is not ideal. Moreover, current drugs have a variety of toxicity and side effects. Therefore, there is an urgent need for new cold therapy drugs to overcome the above deficiencies.

In view of the above problems, the present invention provides a drug for treating colds that can solve the problems or at least part of the problems, which is used to overcome the deficiency of the poor therapeutic effect of the drug in the prior art.

According to a first aspect, the present invention provides a drug for treating colds, comprising Fructus forsythiae 10-20, Perilla leaf 10-15, and Dandelion 3-20, based on parts by weight. .

According to a second aspect, the present invention provides a method of preparing a medicament according to any one of the preceding embodiments, comprising the following steps:

First step: Weighing 10-20, Perilla leaf 10-15 and Dandelion 3-20, based on parts by weight;

Second step: preparing each of the raw materials into decoction pieces and cooking the decoction pieces for 30-60 minutes using a pressure cooker for sterilization;

Third step: cooling, filtering through a 100-250 mesh filter cloth and concentrating the resultant to obtain a thick paste;

Step 4: Drying, grinding and sieving the thick paste to obtain the desired drug:

The present invention relates to a drug for treating colds and a method for producing the same, the drug for treating colds according to the present invention has a different component compared to the drug in the prior art, and can overcome the deficiency of the drug in the prior art.

Detailed description of the embodiments

In an embodiment of the present invention, a drug for treating a cold is provided, on a part by weight basis, comprising Falonia 10-20, Perilla Leaf 10-15, and Dandelion 3-20.

In addition, the drug further comprises fresh ginger (20-50) by weight.

In addition, the drug further comprises Agastache rugosus 2-22 on a weight basis.

The fresh ginger and kwakyang are only some specific examples, not intended to be limited to this, wolfberry fruit (wolfberry fruit), Gynostemma pentaphyllum, 12 (Semen Astragali Complanati), Radix Dipsaci, Hanbacho (Herba) Other substances are also possible, such as Eclipta) and the Fructus Ligustri Lucidi. Other possible materials will not be described in detail.

Optionally, in an embodiment of the present invention, a substance for activating blood circulation, such as Carcuma longa, Ligusticum chuanxiong Hort., Radix Salviae Miltiorrhizae and Evening Primrose, is provided. It may further include.

In addition, in an embodiment of the present invention, in order to enhance the pharmacological effect, the drug is Gardenia (Fructus Gardeniae), Chrysanthemum (Flos Chrysanthemi), Semen Cassiae, Cortex fraxini, Red ginseng (Radix Sophorae Flavescentis) It may further include a substance for purifying heat, such as Floss Chrysanthemi Indici, Andrographis paniculata, and the like.

In addition, the drug may further include a substance for purifying damp and promoting diuresis, such as Herba Sedi, Abrus Herb, and the like.

In addition, the drug may further include a substance for warming the body such as pepper.

In an embodiment of the invention, the dosage form of the drug is a film-coated tablet, sugar coated tablet, enteric tablet, dispersible tablet, capsule, granule, powder, mixture, syrup, medicinal wine, injection, oral solution and oral At least one of the turbidity.

In an embodiment of the invention, optionally, the drug is an oral-dose formulation.

In an embodiment of the invention, optionally, the oral-administration formulation comprises a tablet, capsule, pill, injectable, sustained release formulation, and controlled release formulation.

The drug of the embodiment provided in the present invention or a drug composition comprising the same may be administered in unit dosage form through the intestine, nasal cavity, oral mucosa, eyes, lungs, airways, skin, rectum and the like, oral administration, intravenous injection, muscle It can be administered by internal injection and subcutaneous injection.

The dosage form may be a liquid dosage form, a solid dosage form or a semi-solid dosage form. The liquid formulations may be solutions, emulsions, suspensions, injections (including water injections, powder injections and transfusions), eye drops, nasal drops, lotions and liniments; Such solid dosage forms include tablets (including uncoated tablets, enteric tablets, buccal tablets, dispersible tablets, chewable tablets, effervescent tablets, orally disintegrating tablets), capsules (including hard capsules, soft capsules, enteric capsules) , Granules, powders, pellets, dropping pills, suppositories, films, pastes, aerosols, sprays, and the like; The semi-solid formulation can be an ointment, a gel, a paste or the like. Formulations of the drug are preferably tablets, capsules, pills, and injections.

Drugs according to embodiments of the invention can be prepared in conventional formulations, sustained release formulations, controlled release formulations, targeting preparations, and various granule dosage formulations.

In embodiments of the present invention, various excipients may be used, such as diluents, binders, wetting agents, disintegrants, lubricants and glidants, to prepare the drugs of the present invention into tablets. The diluent may be starch, dextrin, sucrose, glucose, lactose, mannitol, sorbitol, xylitol, microcrystalline cellulose, calcium sulfate, calcium hydrogen phosphate, calcium carbonate and the like; The wetting agent may be water, ethanol, isopropanol and the like; The binder may be starch pulp, dextrin, syrup, honey, glucose solution, microcrystalline cellulose, gum arabic pulp, gelatin pulp, sodium carboxymethyl cellulose and methyl cellulose; The disintegrant may be anhydrous starch, microcrystalline cellulose, low-substituted hydroxypropyl cellulose; The lubricant and lubricant may be talc, silica, stearate, liquid paraffin, and the like.

In addition, the drug may also be coated tablets, such as sugar coated tablets, film coated tablets, enteric tablets, and the like.

When the drug is prepared in capsules, the active ingredient can be prepared into granules or pellets by the addition of diluents, binders and disintegrants, which are then placed in hard capsules or soft capsules.

When the drug is prepared as an injection, the solvent may be prepared from water, ethanol, isopropanol, propylene glycol, or mixtures thereof. In addition, an appropriate amount of solubilizer, cosolvent, pH adjuster, osmotic pressure adjuster may be added.

In addition, the drug may be added with colorants, preservatives, perfumes, corrigents or other additives.

In an embodiment of the invention, there is provided a method of preparing the drug, comprising the following steps:

First step: Weighing 10-20, Perilla leaf 10-15 and Dandelion 3-20, based on parts by weight;

Second step: preparing each of the raw materials into decoction pieces and cooking the decoction pieces for 30-60 minutes using a pressure cooker for sterilization;

Third step: cooling, filtering through a 100-250 mesh filter cloth and concentrating the resultant to obtain a thick paste;

Fourth Step: Drying, grinding and sieving the thick paste to obtain the desired drug:

In the following, several specific examples of a method of preparing a drug for treating a cold are provided.

Example 1

First step: weighing and mixing duct bridge 10-20, perilla leaf 10-15 and dandelion 3-20, based on parts by weight, to obtain a mixture;

Second step: adding an appropriate amount of water to the mixture of duct bridge, perilla leaf and dandelion and soaking for 8 hours until the mixture is completely soaked;

Third step: adding 20 g of fresh ginger to the mixture, heating at 30 ° C. for 4 hours, and adding 10 ml of water every 30 minutes;

Fourth step: heating the mixture for 4 hours and leaving at room temperature for 12 hours;

Fifth step: filtering the mixture through a 100-250 mesh filter cloth and concentrating the resultant to obtain a thick paste;

Step 6: drying, pulverizing and sieving the thick paste to obtain the desired drug

Example 2

First step: weighing, mixing, perilla, dandelion, and dandelion to obtain a mixture;

Second step: adding an appropriate amount of water to the mixture of the persimmon, duct, perilla leaf and dandelion and soaking for at least 8 hours until the mixture is completely wetted;

Third step: adding 20 g of Semen Armeniacae Amarum to the mixture, heating at 30 ° C. for 4 hours, and adding 10 ml of water every 30 minutes;

Fourth step: heating the mixture for 4 hours and leaving at room temperature for 12 hours;

Fifth step: filtering the mixture through a 100-250 mesh filter cloth and concentrating the resultant to obtain a thick paste;

Step 6: drying, pulverizing and sieving the thick paste to obtain the desired drug

Example 3 (Preparation of Granules)

First step: weighing, mixing, perilla, dandelion, and dandelion to obtain a mixture;

Second step: adding an appropriate amount of water to the mixture of the persimmon, duct, perilla leaf and dandelion and soaking for at least 8 hours until the mixture is completely wetted;

Third step: adding 20 g of almond to the mixture, heating at 30 ° C. for 4 hours, and adding 10 ml of water every 30 minutes;

Fourth step: heating the mixture for 4 hours and leaving at room temperature for 12 hours;

Step 5: The mixture was filtered to obtain a filtrate, and the filtrate was concentrated in vacuo to obtain an extract having a relative density of 1.25 (60 ° C.), and the extract was mixed with 3 times the amount of dextrin to obtain a soft material, and vibrating granules. Preparing granules with a machine;

Step 6: Drying the granules at 65 ° C. for 30 minutes, finishing the granules, sifting and packing to remove small granules.

Example 4 (Preparation of Tablets)

First step: Weighing 10-20, Perilla leaf 10-15 and Dandelion 3-20, based on parts by weight, and mixing to obtain a mixture;

Second step: adding an appropriate amount of water to the mixture of duct bridge, perilla leaf and dandelion and soaking for 8 hours until the mixture is completely wet;

Step 3: adding 20 g of Rhizoma Dioscoreae to the mixture, heating at 30 ° C. for 4 hours, and adding 10 ml of water every 30 minutes;

Fourth step: heating the mixture for 4 hours and leaving at room temperature for 12 hours;

Step 5: The mixture was filtered to obtain a filtrate, and the filtrate was concentrated in vacuo to obtain an extract having a relative density of 1.25 (60 ° C.), and the extract was mixed with three times the amount of dextrin to obtain a soft material, and vibrating granules. Preparing granules with a machine;

Step 6: Drying the granules at 65 ° C. for 30 minutes and tableting with a single-punch tablet press to obtain a tablet having a mass of 0.3 g.

Example 5

First step: duct bridge, perilla leaf and dandelion are carefully selected, washed, weighed according to a specific ratio and mixed uniformly to obtain starting material;

Step 2: Add the starting material to purified water and cook the resultant 3-4 times 40-80 minutes at a time in a steam autoclave, extract thick paste with each cooking, and filter with 100-250 mesh Filtering the thick paste;

Third step: uniformly mixing all the thick paste;

Step 4: drying, pulverizing and sieving the uniformly mixed thick paste to obtain the desired drug:

The drug of the present invention may be administered alone or in combination with other therapeutic drugs. If there is a synergistic effect between the drug of the present invention and other therapeutic drugs, the dosage of the drug of the present invention may be adjusted as necessary. The above embodiments have been used for illustrative purposes only and are not intended to be limiting.

Claims (5)

A drug for the treatment of colds, comprising Fate 10-20, Perilla leaf 10-15, and Dandelion 3-20, based on parts by weight. The drug of claim 1, further comprising fresh ginger 20-50, based on parts by weight. The drug for treating colds according to claim 1, further comprising Contour 2-22, based on parts by weight. The formulation of claim 1, wherein the formulation of the drug is in film-coated tablets, sugar coated tablets, enteric tablets, dispersible tablets, capsules, granules, powders, mixtures, syrups, medicinal wines, injectables, oral solutions and oral suspensions. It is at least one, drugs for treating colds. A method of making a drug according to any one of claims 1 to 4 comprising the following steps:
First step: Weighing 10-20, Perilla leaf 10-15 and Dandelion 3-20, based on parts by weight;
Second step: preparing each of the raw materials into pieces of sugar, and cooking the pieces of sugar for 30-60 minutes using a pressure cooker for sterilization;
Third step: cooling, filtering with 100-250 mesh of filter cloth and concentrating the resultant to obtain a thick paste;
Step 4: Drying, grinding and sieving the thick paste to obtain the desired drug: