CN105055658A - Medicine for treating liver meridian damp-heat type infantile enuresis and preparation method thereof - Google Patents

Abstract

The invention discloses a medicine for treating liver meridian damp-heat type infantile enuresis and a preparation method thereof, wherein, the medicine is prepared from the following raw herbal materials: rauwolfia, sheepear inula herb, rubia cordifolia, fortune firethorn fruit, campsis grandiflora, calamitas urinae hominis, dracocephalum heterophyllum, creeping oxalis, malvastrum coromandelianum, narrow-leaved lindernia, goat-ear elecampane root, aralis root, climbing fig, herb of wight parnassia, mallotus apelta, physalis angulata, blumea, angled bittersweet root, trifoliate acanthopanax root or root-bark, prepared rehmannia root, fructus lycii, chrysanthemum, herba ecliptae, ganoderma lucidum, lotus seed, pimpinella thellungiana, eastern bracken fern rhizome, fructus aurantii, cynanchum wilfordii and seedling of mapleleaf excoecaria. The medicine for treating the liver meridian damp-heat type infantile enuresis has the beneficial effects of purging the liver of pathogenic fire and clearing damp, clearing away heat and toxic materials, nourishing kidney yin, and benefiting qi for tranquillization; according to the medicine provided by the invention, the theory of traditional Chinese medicine is utilized; treatment based on syndrome differentiation is performed; the pertinence is higher; the curative effect is significant; each herbal material contains a variety of pharmacological ingredients, and has a wide range of indication; the toxic and side effects are low, and the curative effect is significant.

Description

Be used for the treatment of medicine of ascites of liver meridian damp-heat type bed-wetting and preparation method thereof

Technical field

The present invention relates to pharmaceutical technology, be particularly a kind ofly used for the treatment of medicine of ascites of liver meridian damp-heat type bed-wetting and preparation method thereof.

Background technology

Bed-wetting, also known as " bed-wetting ", refers to that the children's of age more than 5 years old sleeps middle incontinence of urine, a kind of disease that rear of waking up is felt.Morbidity and vigour are not filled, and lung, spleen, renal dysfunction are relevant.Be divided into constitutional (primarynocturnalenuresisPNE) and secondary enuresis (SNE), wherein since the childhood with regard to the enuresis, and do not have urethral disease and sustainable existence bed wetter is called primary enuresis.Secondary enuresis refers to that children's can control to urinate at least 1 year, but continue after there is bed wetter again.According to whether with daytime symptoms (with urgent micturition, frequent micturition, urinary incontinence), be divided into again the monosymptom enuresis (MNE) (without daytime symptoms) and the complexity enuresis (CNE).Bed-wetting is a kind of common disease of children's, sickness rate report differs, on average account for the 2.3%-25% of pediatric population, because this disease has certain self limiting, therefore the head of a family does not have too large attention to this kind of disease in the past, thinking with advancing age can slowly spontaneous recovery, but most of infant enuresis symptom is not eased with advancing age, on the contrary great pressure is caused to the psychology of infant and spirit, have influence on sense of personal worth and the self-confidence of infant, infant is caused easily to occur absent minded, irritability, there is hallucination etc., the school grade of child is caused to decline and the adverse consequences such as unsociable and eccentric, affect physical and mental health and the growth promoter of child.Too increase the burden of the head of a family simultaneously.

The cause of disease of bed-wetting:

Ancient Chinese medicine doctor all think the Etiological of bed-wetting have with F some: (1) innate deficiency: children's's innate deficiency, ferritic is weak, and deficiency of kidney-QI, lower first deficiency and coldness, can not restrict water liquid, go out and can't help for the enuresis.(2) lack of proper care after being ill: after serious disease prolonged illness, lose in taking good care of, cause spleen to transport mistake and be good for, insufficiency of lung-QI, deficiency of the upper portion of the body resulting in inability to control the lower portion forms the enuresis.(3) retention of damp-heat in the interior: or because of sickness influence, or because of drinking and eating irregularly, so that retention of damp-heat in the interior, strongly fragrant in Liver Channel, catharsis is lacked of proper care, and moves heat and causes the enuresis in bladder.(4) disorder of emotion: get a fright suddenly, or lack education since the childhood because of children's, does not form good night urination custom, or laughs and frolick daytime excessively because of children's, and sleeping at night is excessively dark, or changes environment suddenly, can cause the enuresis.(5) other factors: Recent study represents children's's spina bifida occulta, wean urethra deformity, rich parasitosis, spinal cord injury etc. can cause bed-wetting.

Bed-wetting medicine typing:

1. time lose symptom without empty: the middle enuresis of sleeping, notably a night is for several times, and urine is clear long and frequently many, sleep soundly and not easily wakes up, face look down Mental fatigue, lassitude loin and legs, hypomnesis or intelligence poor, light red tongue tongue is few, thready pulse.

2. asthenia of pulmonosplenic qi symptom: body is empty after being ill, the middle enuresis of sleeping, frequent micturition and measure few, the few China of pallor, spiritlessness and weakness, inappetence, half congealed during stool, spontaneous sweating, pale tongue is fat, thin white fur of tongue, and thready and soft pulse is unable.

3. dampness-heat of the liver symptom: the middle enuresis of sleeping, yellow urine is smelly, flushed face and red lips, irascible temperament, and night chews tooth, tongue fur BOHUANG, rolling pulse.

The Therapeutic Method of current clinical report has a lot, includes the methods such as the behavior therapy, oral western medicine treatment, traditional Chinese medical science internal treatment, external treatment of Chinese medicine (having acupuncture, massage, chiropractic, massage, acupoint injection therapy medicine, catgut implantation at acupoint, medicine to apply amine), the combination of Chinese and Western medicine.

, there is the more curative effect of side effect unstable, the problem of easily recurrence after drug withdrawal in western medical treatment bed-wetting.And behavior intervene, effect is not remarkable in a short time, thus only coordinates western medicine as complementary therapy clinically.The pattern that the Pathophysiology feature that someone gives chapter and verse infant carries out treating to formulate therapeutic scheme, this pattern has been proved more traditional administrated method significance curative effect, but because its treatment checking process is more complicated, infant and the head of a family are difficult to coordinate, and thus can not be widely used in clinical.To develop programs according to infant individual characteristic the principle of carrying out treating, just meeting China's traditional medicine determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs principle.

Chinese medicine bed-wetting utilizes Traditional Chinese medical theory, great attention to whole idea: determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, and specific aim is comparatively strong, evident in efficacy; Each herbal medicine contains multiple pharmaceutical component, and indication is extensive; Toxic and side effects is low, evident in efficacy; Convenient drug administration, patient is easy to accept.

Summary of the invention

The technical problem to be solved in the present invention there are provided one and has eliminating pathogen in the liver damp eliminating, heat-clearing and toxic substances removing, nourishing kidney yin, and effect of benefiting vital QI for tranquillizing cures mainly the medicine of ascites of liver meridian damp-heat type bed-wetting; The present invention utilizes Traditional Chinese medical theory, great attention to whole idea: by determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, and specific aim is comparatively strong, evident in efficacy; Each herbal medicine contains multiple pharmaceutical component, and indication is extensive; Toxic and side effects is low, evident in efficacy; Convenient drug administration, patient is easy to accept, and can carry out clinical market exploitation.

In order to realize foregoing invention object, the invention provides a kind of medicine being used for the treatment of ascites of liver meridian damp-heat type bed-wetting, described medicine comprises following raw medicinal material: Radix Rauvolfiae, Herba Inulae cappae, Radix Rubiae, Fructus Pyracanthae (Fructus Pyracanthae Fortuneanae), Flos Campsis, calamitas urinae hominis, dracocephalum heterophyllum, Herba Oxalidis Corniculatae, Herba Malvastri Coromandeliani, Lindernia angustifolia (Benth.) Wettst., Radix Inulae Cappae, Radix araliae chinensis (Cortex Araliae Chinensis), Caulis fici pumilae (Fructus Fici Pumilae), Herba Parnassiae Wightianae, Folium Malloti Apeltae, Herba Physalis pubescentis, Herba Blumeae Lacerae, Radix Celastri Angulati, Radix Acanthopanacis Trifoliati, Radix Rehmanniae Preparata, Fructus Lycii, Flos Chrysanthemi, Herba Ecliptae, Ganoderma, Semen Nelumbinis, Herba Pimpinellae thellungianae, Rhizoma pteridii latiusculi, Fructus Aurantii, Radix cynanchi wilfordii and Plantula Excoecariae Acerifoliae.

In described medicine, the ratio of weight and number of each raw medicinal material is: Radix Rauvolfiae 6-13 part, Herba Inulae cappae 11-18 part, Radix Rubiae 13-17 part, Fructus Pyracanthae (Fructus Pyracanthae Fortuneanae) 5-11 part, Flos Campsis 3-9 part, calamitas urinae hominis 2-6 part, dracocephalum heterophyllum 20-30 part, Herba Oxalidis Corniculatae 9-13 part, Herba Malvastri Coromandeliani 12-21 part, Lindernia angustifolia (Benth.) Wettst. 10-17 part, Radix Inulae Cappae 13-21 part, Radix araliae chinensis (Cortex Araliae Chinensis) 5-11 part, Caulis fici pumilae (Fructus Fici Pumilae) 1-3 part, Herba Parnassiae Wightianae 6-15 part, Folium Malloti Apeltae 4-11 part, Herba Physalis pubescentis 16-28 part, Herba Blumeae Lacerae 8-13 part, Radix Celastri Angulati 13-17 part, Radix Acanthopanacis Trifoliati 9-18 part, Radix Rehmanniae Preparata 21-33 part, Fructus Lycii 18-30 part, Flos Chrysanthemi 11-23 part, Herba Ecliptae 14-28 part, Ganoderma 19-30 part, Semen Nelumbinis 22-36 part, Herba Pimpinellae thellungianae 12-23 part, Rhizoma pteridii latiusculi 4-9 part, Fructus Aurantii 12-18 part, Radix cynanchi wilfordii 10-17 part and Plantula Excoecariae Acerifoliae 10-21 part.

In described medicine, the ratio of weight and number of each raw medicinal material is: Radix Rauvolfiae 6 parts, Herba Inulae cappae 18 parts, 14 parts, Radix Rubiae, Fructus Pyracanthae (Fructus Pyracanthae Fortuneanae) 11 parts, Flos Campsis 4 parts, calamitas urinae hominis 5 parts, dracocephalum heterophyllum 20 parts, Herba Oxalidis Corniculatae 13 parts, Herba Malvastri Coromandeliani 18 parts, Lindernia angustifolia (Benth.) Wettst. 10 parts, Radix Inulae Cappae 21 parts, Radix araliae chinensis (Cortex Araliae Chinensis) 9 parts, Caulis fici pumilae (Fructus Fici Pumilae) 2 parts, Herba Parnassiae Wightianae 15 parts, Folium Malloti Apeltae 4 parts, Herba Physalis pubescentis 16 parts, Herba Blumeae Lacerae 8 parts, Radix Celastri Angulati 17 parts, Radix Acanthopanacis Trifoliati 9 parts, Radix Rehmanniae Preparata 30 parts, Fructus Lycii 18 parts, Flos Chrysanthemi 23 parts, Herba Ecliptae 28 parts, Ganoderma 30 parts, 36 parts, Semen Nelumbinis, Herba Pimpinellae thellungianae 12 parts, Rhizoma pteridii latiusculi 6 parts, Fructus Aurantii 18 parts, Radix cynanchi wilfordii 17 parts and Plantula Excoecariae Acerifoliae 21 parts.

In described medicine, the ratio of weight and number of each raw medicinal material is: Radix Rauvolfiae 13 parts, Herba Inulae cappae 17 parts, 13 parts, Radix Rubiae, Fructus Pyracanthae (Fructus Pyracanthae Fortuneanae) 8 parts, Flos Campsis 3 parts, calamitas urinae hominis 6 parts, dracocephalum heterophyllum 25 parts, Herba Oxalidis Corniculatae 12 parts, Herba Malvastri Coromandeliani 21 parts, Lindernia angustifolia (Benth.) Wettst. 17 parts, Radix Inulae Cappae 13 parts, Radix araliae chinensis (Cortex Araliae Chinensis) 11 parts, Caulis fici pumilae (Fructus Fici Pumilae) 3 parts, Herba Parnassiae Wightianae 6 parts, Folium Malloti Apeltae 7 parts, Herba Physalis pubescentis 28 parts, Herba Blumeae Lacerae 10 parts, Radix Celastri Angulati 13 parts, Radix Acanthopanacis Trifoliati 18 parts, Radix Rehmanniae Preparata 21 parts, Fructus Lycii 30 parts, Flos Chrysanthemi 11 parts, Herba Ecliptae 16 parts, Ganoderma 28 parts, 22 parts, Semen Nelumbinis, Herba Pimpinellae thellungianae 23 parts, Rhizoma pteridii latiusculi 4 parts, Fructus Aurantii 16 parts, Radix cynanchi wilfordii 15 parts and Plantula Excoecariae Acerifoliae 19 parts.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Radix Rauvolfiae 11 parts, Herba Inulae cappae 11 parts, 17 parts, Radix Rubiae, Fructus Pyracanthae (Fructus Pyracanthae Fortuneanae) 5 parts, Flos Campsis 9 parts, calamitas urinae hominis 2 parts, dracocephalum heterophyllum 30 parts, Herba Oxalidis Corniculatae 9 parts, Herba Malvastri Coromandeliani 12 parts, Lindernia angustifolia (Benth.) Wettst. 15 parts, Radix Inulae Cappae 16 parts, Radix araliae chinensis (Cortex Araliae Chinensis) 5 parts, Caulis fici pumilae (Fructus Fici Pumilae) 1 part, Herba Parnassiae Wightianae 12 parts, Folium Malloti Apeltae 11 parts, Herba Physalis pubescentis 23 parts, Herba Blumeae Lacerae 13 parts, Radix Celastri Angulati 16 parts, Radix Acanthopanacis Trifoliati 11 parts, Radix Rehmanniae Preparata 33 parts, Fructus Lycii 24 parts, Flos Chrysanthemi 17 parts, Herba Ecliptae 14 parts, Ganoderma 19 parts, 33 parts, Semen Nelumbinis, Herba Pimpinellae thellungianae 14 parts, Rhizoma pteridii latiusculi 9 parts, Fructus Aurantii 12 parts, Radix cynanchi wilfordii 10 parts and Plantula Excoecariae Acerifoliae 10 parts.

When the dosage form of described medicine is decoction, its preparation method comprises the following steps:

Step one: purple casserole is put in described raw medicinal material mixing, adds clear water, to clear water dipped medical material upper surface 2-5cm, soak 0.5-1 hour;

Step 2: purple casserole is placed on fire, after intense fire boils, using slow fire instead, to decoct the 30-50 minute dosage to medicinal liquid be slowly 100-300ml, filters, obtain filtrate a, for subsequent use;

Step 3: residue medicinal residues are added clear water again, to clear water dipped medical material upper surface 2-3cm, soaks 1-2 hour;

Step 4: be placed in by purple casserole on fire, after intense fire boils, using slow fire instead, to decoct the 25-35 minute dosage to medicinal liquid be slowly 100-300ml, filters, obtain filtrate b, mixed by filtrate a and filtrate b.

When the dosage form of described medicine is granule, its preparation method comprises the following steps:

Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 4 ~ 8 times, mixture is the ethanol of 85% ~ 95%, be heated to boiling reflux 3 ~ 5 hours, filter, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.09Mpa, relative density is the mastic of 1.04 ~ 1.10, spraying dry, the inlet temperature 160 ~ 175 DEG C of spray dryer, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder;

Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 ~ 0.4 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes granule, in 40 ~ 50 DEG C of dryings, obtains granule.

When the dosage form of described medicine is honey refining pill, its preparation method comprises the following steps:

Step 1: first Radix Rauvolfiae, Herba Inulae cappae, Radix Rubiae, Fructus Pyracanthae (Fructus Pyracanthae Fortuneanae) and Flos Campsis are mixed in described ratio, distillation crystallization obtains powder;

Step 2: get surplus stock medical material again and mix in described ratio, add relative to 83-94% soak with ethanol 1-2 hour of mixture 2-6 times amount, heating extraction 2 times, each 1-1.5 hour, merge extractive liquid, 124-150 order filter, be the ultrafiltration post ultrafiltration of 4400-98000 again through the molecular weight that dams, when ultrafiltrate is evaporated to 87 DEG C, relative density is the extractum of 1.04, becomes component 1;

Step 3: step 2 Chinese medicine slag is added 4-6 times amount water soaking 1-2.5 hour, extract 1 time, extraction time is 1.5-2 hour, and thickening filtration is extractum shape, is component 2;

Step 4: said components 1 and component 2 two kinds of extractum are condensed into pasty state, add the powder that a step obtains, add Mel and be twisted into pill.

The invention has the beneficial effects as follows: the present invention has eliminating pathogen in the liver damp eliminating, heat-clearing and toxic substances removing, nourishing kidney yin, effect of benefiting vital QI for tranquillizing, cure mainly ascites of liver meridian damp-heat type bed-wetting.The present invention utilizes Traditional Chinese medical theory, great attention to whole idea: determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, and specific aim is comparatively strong, evident in efficacy; Each herbal medicine contains multiple pharmaceutical component, and indication is extensive; Toxic and side effects is low, evident in efficacy; Convenient drug administration, patient is easy to accept, and can carry out clinical market exploitation.

Detailed description of the invention

" Yifangleiju " is said: " urinator, after body fluid also; The main water of kidney, bladder is blader.Kidney and bladder are all empty and cold air takes advantage of it, therefore can not restrict its water, go out and can't help, the enuresis of meaning." pediatrics releases mystery " is said: " also have heat visitor in kidney portion, do and to faint the warp of the moon in foot, pent-up pole, hole, the court of a feudal ruler very, and can not declare logical by QI and blood, then flaccidity syndrome and arthralgia syndrome and god are without used, therefore liquid infiltrates bladder, and revolve to drown and lose, can not by taboo also.As can be seen here, the enuresis all has deficiency of kidney-QI, below element deficiency and cold, can not replenishing vital QI with drugs of warm nature bladder, and restriction water channel forms.Again because children's's internal organs gas is weak, body Cheng Erwei is complete, and entirely and do not strengthen, if transformation and transportation of the spleen and stomach is vigorous, kidney essense is filled up, and brain is supplemented nutrition, then gods adduction, and brain key obtains clever; If weakness of the spleen and stomach, then increase the weight of deficiency of the kidney.In addition, if stagnated heat of liver channel, qi and blood disorder, gods are lost and are supported, also easy the urinary bladder being out of control and cause the enuresis.

Therefore, the present invention treats ascites of liver meridian damp-heat type bed-wetting, with eliminating pathogen in the liver damp eliminating, heat-clearing and toxic substances removing, nourishing kidney yin, benefiting vital QI for tranquillizing is primary treatment principle, selects prescription: Radix Rauvolfiae, Herba Inulae cappae, Radix Rubiae, Fructus Pyracanthae (Fructus Pyracanthae Fortuneanae), Flos Campsis, calamitas urinae hominis, dracocephalum heterophyllum, Herba Oxalidis Corniculatae, Herba Malvastri Coromandeliani, Lindernia angustifolia (Benth.) Wettst., Radix Inulae Cappae, Radix araliae chinensis (Cortex Araliae Chinensis), Caulis fici pumilae (Fructus Fici Pumilae), Herba Parnassiae Wightianae, Folium Malloti Apeltae, Herba Physalis pubescentis, Herba Blumeae Lacerae, Radix Celastri Angulati, Radix Acanthopanacis Trifoliati, Radix Rehmanniae Preparata, Fructus Lycii, Flos Chrysanthemi, Herba Ecliptae, Ganoderma, Semen Nelumbinis, Herba Pimpinellae thellungianae, Rhizoma pteridii latiusculi, Fructus Aurantii, Radix cynanchi wilfordii and Plantula Excoecariae Acerifoliae.

Wherein, Radix Rauvolfiae, Herba Inulae cappae, Radix Rubiae, Fructus Pyracanthae (Fructus Pyracanthae Fortuneanae), Flos Campsis, calamitas urinae hominis, dracocephalum heterophyllum, Herba Oxalidis Corniculatae removing fire from the liver; Herba Malvastri Coromandeliani, Lindernia angustifolia (Benth.) Wettst., Radix Inulae Cappae, Radix araliae chinensis (Cortex Araliae Chinensis), Caulis fici pumilae (Fructus Fici Pumilae), Herba Parnassiae Wightianae, Folium Malloti Apeltae clearing away heat-damp and promoting diuresis; Herba Physalis pubescentis, Herba Blumeae Lacerae, Radix Celastri Angulati, Radix Acanthopanacis Trifoliati heat-clearing and toxic substances removing; Radix Rehmanniae Preparata, Fructus Lycii, Flos Chrysanthemi, Herba Ecliptae nourishing kidney yin; Ganoderma, Semen Nelumbinis, Herba Pimpinellae thellungianae, Rhizoma pteridii latiusculi benefiting vital QI for tranquillizing; Fructus Aurantii, Radix cynanchi wilfordii, Plantula Excoecariae Acerifoliae spleen benefiting and stimulating the appetite.

Wherein, the pharmacology of above-mentioned raw materials medical material is as follows:

Radix Rauvolfiae: another name taberpsychine, mountain Horse hoof, Fructus Linderae Glaucae, rauwolfia (" will planted by middle traditional Chinese medicines ").For the root of apocynaceae plant Radix Rauvolfiae.Bitter; Micro-pungent; Cool in nature.Heat clearing away; Blood pressure lowering; Allay excitement.Main cold, fever; Headache body pain; Laryngopharynx swelling and pain; Hypertension; Dizzy; Insomnia.

Herba Inulae cappae: another name hair tiger, pig rumor, energetically Huang, Radix seu Caulis Embeliae Parviflorae, Bai Yeju, machete medicine, leeward in vain.For the herb of feverfew Herba Inulae cappae.Acrid in the mouth; Sweet; Micro-hardship; Warm in nature.Expelling wind and cold; Circulation of qi promoting dampness removing; Removing toxic substances and promoting subsidence of swelling.Main anemofrigid cold; Cough; Rheumatic arthralgia; Let out dysentery; Hepatitis; Mastitis; Hemorrhoid; Eczema; Scabies.

Radix Rubiae: another name Galium spurium L., uproot plants after their edible portions have been harvested, HUOXUECAO, red Radix Rubiae, carriage, extension draw bean, red line grass, Radix seu Caulis Schisandrae Sinensis, Herba Chenopodii Hybridi.This product is the dry root and rhizome of Maguireothamnus speciosus Radix Rubiae.Hardship, cold.Return Liver Channel.Removing heat from blood, hemostasis, blood stasis dispelling, stimulates the menstrual flow.For spitting blood, epistaxis, metrorrhagia, traumatic hemorrhage, amenorrhea stasis blocking, arthralgia, tumbling and swelling.

Fructus Pyracanthae (Fructus Pyracanthae Fortuneanae): another name rescues army provisions, red fruit, Chinese firethom, torch fruit (" the southern regions of the Yunnan Province book on Chinese herbal medicine "), Fructus Pyracanthae (" classifying herbal "), Fortune Firethorn Fruit (" Chinese Seed plant taxonomy)), water sand (" Traditional Chinese Medicine in Sichuan will ").For the fruit of rosaceous plant fire sour jujube.Sweet; Acid; Puckery; Flat; Nontoxic.Return liver; Spleen; Stomach warp.Spleen invigorating removing food stagnancy; Convergence dysentery relieving; Pain relieving.Main mass in the abdomen; Food stagnation is stagnated; Distension and fullness in the abdomen; Have loose bowels; Dysentery; Metrorrhagia; Leukorrhagia; Traumatic injury.

Flos Campsis: another name Radix campsis, Herba Ipomoeae Cairicae, Flos Carthami Thalictrum omeiense W. T. Wang et S. H. Wang, fuchsia, the dragon that climbs the tree, Hedera nepalensis var. sinensis, white Canis familiaris L. intestinal, hanging screen flower, induced abortion flower.This product is the dried floral and root that bavin Wei section plant is reached the clouds or reach the clouds in America.Acid, cold.Enter Liver Channel.Removing heat from blood blood stasis removing.Control amenorrhea due to stagnation of blood, lump in the abdomen, heat in blood pruritus due to wind pathogen, rosacea.The present invention's flower.

Calamitas urinae hominis: this product is thin slice or the block sheet of the canescence amorphism condensed in wooden pail for urine or urine cylinder, and clean dry forms.Salty, cold.Enter liver, three burnt, urinary bladder channels.Heat-clearing and toxic substances removing, hemostasis by removing blood stasis.For laryngopharynx swelling and pain, ulcerative gingivitis aphtha, the diseases such as spitting of blood, epistaxis.

Dracocephalum heterophyllum: the lucky diligent green grass or young crops of another name protects (Tibetan name).This product is the dry aerial parts of labiate dracocephalum heterophyllum.Sweet, cold.Clear eliminating pathogen in the liver heat.For icterohepatitis, the gingival swelling and pain that liver-fire rises, hemorrhage, oral ulcer.

Herba Oxalidis Corniculatae: call Oxalis corniculata Linn., acid acid is careless, Strepopelia orientalis is sour, three folic acid.The oxalic herb of Oxalidaceae plant.Acid, cool.Clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling.For cold, fever, enteritis, urinary tract infection, lithangiuria, neurasthenia; Traumatic injury is controlled in external, venom, carbuncle furuncle, tinea pedis, eczema, burn and scald.

Herba Malvastri Coromandeliani: call Coromadel Coast Falsemallow Herb, mountain Corchorus olitorius L., great Ye Hemerocallis citrina Baroni is violent, Prunus davidiana is young.Malvaceae Herba Malvastri Coromandeliani platymiscium Herba Malvastri Coromandeliani, with all herbal medicine.Sweet, light, cool.Clearing away heat-damp and promoting diuresis, removing toxic substances dissipating blood stasis.For enteritis of catching a cold, dysentery, icterohepatitis, rheumatic arthritis; Traumatic injury is controlled in external, furuncle, carbuncle.

Lindernia angustifolia (Benth.) Wettst.: another name Cornu Caprae seu Ovis Fructus Persicae, Herba Hedyotidis Diffusae (" Guizhou medical herbs "), She Ercao (" catalogue planted by Guizhou medicine "), Tian Suxiang, field Fructus Musae (Jinjiang, Fujian Province " Chinese herbal medicine handbook ").For the herb of goatweed narrow leaf Herba Linderniae Crustaceae.Acrid in the mouth; Bitter; Property is put down.Clearing away heat-damp and promoting diuresis; Removing toxic substances and promoting subsidence of swelling.Main jaundice due to damp-heat; Have loose bowels; Dysentery; Laryngopharynx swelling and pain; Traumatic injury.

Radix Inulae Cappae: another name Inula cappa (Ham.) DC., the native Radix Angelicae Dahuricae (" the SHENGCAO property of medicine is standby to be wanted "), black GUFENG (" investigation report planted by Kunming medicine "), Herba Aristolochiae Mollissimae, iron perfume (or spice) (" Traditional Chinese Medicine in Sichuan will "), Herba Inulae cappae root (" Quanzhou book on Chinese herbal medicine ").For the root of feverfew Herba Inulae cappae.Pungent, temperature.Expelling wind and cold, relaxing muscles and tendons to promote blood circulation.Control anemofrigid cold, cough, asthma, rheumatic arthralgia, menoxenia." practical Chinese herbal medicine ": " dispelling wind to relieve the exterior syndrome, damp eliminating diuretic.Catch a cold after managing property, postnatal blood stasis cancer, anuresis during pregnancy.Hepatitis, stomachache, dyspepsia, stomachache, cold cough, gum erosion, lymphonodi cervicales swells."

Radix araliae chinensis (Cortex Araliae Chinensis): Bie Ming Aralia root (supplement to the Herbal), sting old bag root (" vegetation just side "), mountain Radix tetrapanacis Koch (" Traditional Chinese Medicine in Sichuan will "), arrow is when tree root (" Jiangxi medical herbs ").For Wu adds root or the root bark of section Zhi Wu Cortex araliae chinensis.Pungent, flat.Wind-damp dispelling, diuresis, dissipating blood stasis blood, detumescence poison.Treating rheumatic arthritis, oedema due to nephritis, cirrhotic ascites, acute, chronic hepatitis, stomachache, stranguria with turbid discharge, metrorrhagia, traumatic injury, scrofula, carbuncle.

Caulis fici pumilae (Fructus Fici Pumilae): another name Fructus Fici Pumilae rattan (" Japan hanako materia medica "), wards off calyx (" interrogating book on Chinese herbal medicine "), cliff lotus (" plant name remittance ").For the stem of moraceae plants Caulis fici pumilae (Fructus Fici Pumilae) ,leaf.Acid, flat.Dispel the wind, dampness removing, invigorates blood circulation, removing toxic substances.Control phoenix pain of dampness syndrome, dysentery, gonorrhea, traumatic injury, carbuncle furuncle.

Herba Parnassiae Wightianae: another name Herba Parnassiae foliosae root, water Herba Houttuyniae, money seven, Hydrocotyle vulgaris L..For brave otology Parnassia plant clavus Herba parnassiae is with all herbal medicine.Light, flat.Return lung; Spleen channel.Clearing away lung-heat to relieve cough, diuretic damp eliminating.For chronic cough spitting of blood, malaria, renal calculus, cholelithiasis, leucorrhea, traumatic injury; Damp and hot sore is controlled in external.Lightly seasoned, cool in nature.

Folium Malloti Apeltae: call wild paulownia, Ye Xiabai, carry on the back wood in vain, carry on the back ma, Bai Piaoshu, white crown in vain.For Euphorbiaceae Mallotus plant Folium Malloti Apeltae is used as medicine with root and leaf.

Herba Physalis pubescentis: another name Fructus Seu Herba Pubescentis, Herba seu Fructus Physalis Minimae, Herba seu Fructus Physalis Minimae, yellow Miss, little Calyx seu fructus physalis, Piao Piaocao, Da Epao.Solanaceae monkey flower Herba Physalis pubescentis is with fruit, root or all herbal medicine.Hardship, cold.Heat-clearing and toxic substances removing, swelling diuretic.For laryngopharynx swelling and pain, parotitis, acute and chronic tracheitis, lung abscess, dysentery, orchitis, dysuria; Impetigo is controlled in external.

Herba Blumeae Lacerae: another name Hemerocallis citrina Baroni Scabrous Elephantfoot Herb.Compositae Herba Blumeae Balsamiferae platymiscium is shown in the herb that frost is yellow.Hardship, cold.Heat-clearing and toxic substances removing, reducing swelling and alleviating pain.For tonsillitis, stomatitis, gingival abscess, mumps, infantile pneumonia; Carbuncle pyogenic infections from tumour or sore is controlled in external, skin pruritus.

Radix Celastri Angulati: another name horse is heartbroken, Radix Raphani medicine, greatly Coriaria sinica, Actinidia (" China's economic flora "), tiger fiber crops (" Guizhou medical herbs "), Ramulus et Folium Pcrasmae (Cortex Picrasmae), dish medicine, rib branch Celastrus orbiculatus Thunb., large Herba Veronicastri (" Shaanxi Chinese herbal medicine ").For root or the root bark of Celastraceae plant Celastrus angulatus.

Radix Acanthopanacis Trifoliati: another name Cortex Acanthopancis (" this thin membrane inside rush stalk of the southern regions of the Yunnan Province "), white Jin root (" the SHENGCAO property of medicine is standby to be wanted "), Bai Cigen, Shan Wujia (" vegetation is side just ").For root or the root bark of the white Jin of Araliaceae.Toil, cool.Enter liver, kidney, stomach three warp.Heat-clearing and toxic substances removing, expelling wind and removing dampness, relaxing muscles and tendons to promote blood circulation.Cure cold high heat, cough with blood-flecked phlegm, rheumatic arthritis, jaundice, leucorrhea, lithangiuria, traumatic injury, furuncle and phyma skin infection.

Radix Rehmanniae Preparata: sweet, tepor.Return liver, kidney channel.Nourishing YIN and supplementing blood, beneficial essence fills out marrow.For the hepatic and renal YIN deficiency, soreness of the waist and knees, osteopyrexia and fever, night sweat is passed out semen, and interior-heat is quenched one's thirst, blood deficiency and yellow complexion, severe palpitation, menoxenia, and metrostaxis is dizzy, tinnitus, early whitening of beard and hair.

Fructus Lycii: sweet is flat.Return liver, kidney channel.Nourishing the liver and kidney, replenishing vital essence to improve eyesight.For asthenia damage of essence, soreness of waist and knee joint, vertigo and tinnitus, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, and blurred vision is failed to understand.

Flos Chrysanthemi: sweet, bitter, is slightly cold.Return lung, Liver Channel.Loose wind heat clearing away, suppressing the hyperactive liver improving eyesight.For anemopyretic cold, have a headache dizzy, conjunctival congestion and swelling pain, eyes is dim-sighted.

Herba Ecliptae: call Herba Ecliptae, floods and droughts lotus, Alternanthera sessilis (L.) DC., spend Sesarmae dehaani grass in vain.This product is the dry aerial parts of feverfew Eclipta prostrata.Sweet, sour, cold.Return kidney, Liver Channel.Nourishing the liver and kidney, cooling blood for hemostasis.For odontoseisis, early whitening of beard and hair, vertigo and tinnitus, soreness of the waist and knees, YinXuXueRe, haematemesis, epistaxis, hematuria, dysentery, metrostaxis, traumatic hemorrhage.

Ganoderma: sweet, flat.GUIXIN, lung, liver, kidney channel.Invigorating QI and tranquilization, relieving cough and asthma.For dizzy sleeplessness, shortness of breath and palpitation, asthenia cough with asthma.Semen Nelumbinis: sweet, puckery are flat.Return spleen, kidney, heart channel.Spleen reinforcing antidiarrheal, kidney tonifying arresting seminal emission, tranquilizing by nourishing the heart.For insufficiency of the spleen chronic diarrhea, seminal emission leukorrhagia, palpitation and insomnia.

Herba Pimpinellae thellungianae: another name sheep flood is had a strong smell, Herba Caryopteridis Terniflorae.For root or the herb of samphire thellung pimpinella herb.Sweet in the mouth; Pungent; Warm in nature.Invigorating the spleen and benefiting QI; Tranquilizing by nourishing the heart; Eliminating phlegm and stopping cough.Main Keshan disease; The heart is reconstructed; Breathe hard; Cough with asthma.

Rhizoma pteridii latiusculi: another name Herba pteridii latiusculi Radix polygalae arillatae (" classifying herbal "), Wu Jiao, little Jiao (" Hunan wild plant ").For the rhizome of Pteridaceae plant Herba pteridii latiusculi.Sweet; Cold; Nontoxic.Return lung; Liver; Spleen; Large intestine channel.Heat clearing away; Dampness removing; Suppressing the hyperactive liver is calmed the nerves; Removing toxic substances and promoting subsidence of swelling.Main heating; Laryngopharynx swelling and pain; Diarrhoea; Dysentery; Jaundice; Leucorrhea; Hypertension; Dizzy insomnia; Rheumatic arthralgia; Hemorrhoid; Proctoptosis; Eczema; Scald; Snake bite and insect sting

Fructus Aurantii: this product is the dry immature fruit of rutaceae Citrus aurantium Linn. and variety thereof.Bitter, pungent, sour, temperature.Return spleen, stomach warp.Regulating the flow of QI to ease the stomach, the stagnant relieving distension of row.For the breast side of body stagnation of QI, distension pain, accumulation of food in the stomach and intes tine due to indigestion, stops in phlegm retention; Gastroptosis, proctoptosis, sub-official's prolapsus.

Radix cynanchi wilfordii: another name Radix cynanchi wilfordii (" classifying herbal "), mountain on the other way round spade (" Tian Bao book on Chinese herbal medicine ").For the tuber of asclepiadaceae plant cynanchum auriculatum Royle.Gan Weixin is flat.Yin nourishing tonify deficiency, strengthening the spleen to promote digestion.Control deficient impairment caused by overstrain, dysentery, infantile malnutrition, have a stomachache glutted, leucorrhea, skin ulcer tinea.

Plantula Excoecariae Acerifoliae: another name scrapes golden plate.Euphorbiaceae Excoecaria plant plait Lignum Aquilariae Resinatum, is used as medicine with Herb.Bitter, pungent, tepor.Expelling wind and cold, invigorating spleen to remove dampness, removing toxic substances.For cough due to wind and cold, malaria, icterohepatitis, dyspepsia, infantile malnutrition, rheumatic ostalgia, amenorrhea, rabies; Separate Radix Aconiti Kusnezoffii, poisonous fungus, alimentary toxicosis.

Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.

Embodiment 1 medicine being used for the treatment of ascites of liver meridian damp-heat type bed-wetting of the present invention

By Radix Rauvolfiae 6g, Herba Inulae cappae 18g, Radix Rubiae 14g, Fructus Pyracanthae (Fructus Pyracanthae Fortuneanae) 11g, Flos Campsis 4g, calamitas urinae hominis 5g, dracocephalum heterophyllum 20g, Herba Oxalidis Corniculatae 13g, Herba Malvastri Coromandeliani 18g, Lindernia angustifolia (Benth.) Wettst. 10g, Radix Inulae Cappae 21g, Radix araliae chinensis (Cortex Araliae Chinensis) 9g, Caulis fici pumilae (Fructus Fici Pumilae) 2g, Herba Parnassiae Wightianae 15g, Folium Malloti Apeltae 4g, Herba Physalis pubescentis 16g, Herba Blumeae Lacerae 8g, Radix Celastri Angulati 17g, Radix Acanthopanacis Trifoliati 9g, Radix Rehmanniae Preparata 30g, Fructus Lycii 18g, Flos Chrysanthemi 23g, Herba Ecliptae 28g, Ganoderma 30g, Semen Nelumbinis 36g, Herba Pimpinellae thellungianae 12g, Rhizoma pteridii latiusculi 6g, Fructus Aurantii 18g, Radix cynanchi wilfordii 17g and Plantula Excoecariae Acerifoliae 21g makes.

The dosage form of medicine is decoction, and its preparation method comprises the following steps:

Step one: purple casserole is put in described raw medicinal material mixing, adds clear water, to clear water dipped medical material upper surface 3cm, soak 1 hour;

Step 2: purple casserole is placed on fire, after intense fire boils, using slow fire instead, to decoct the 50 minutes dosage to medicinal liquid be slowly 100ml, filters, obtain filtrate a, for subsequent use;

Step 3: residue medicinal residues are added clear water again, to clear water dipped medical material upper surface 2cm, soaks 2 hours;

Step 4: be placed in by purple casserole on fire, after intense fire boils, using slow fire instead, to decoct the 35 minutes dosage to medicinal liquid be slowly 100ml, filters, obtain filtrate b, mixed by filtrate a and filtrate b.

Embodiment 2 medicine being used for the treatment of ascites of liver meridian damp-heat type bed-wetting of the present invention

By Radix Rauvolfiae 13g, Herba Inulae cappae 17g, Radix Rubiae 13g, Fructus Pyracanthae (Fructus Pyracanthae Fortuneanae) 8g, Flos Campsis 3g, calamitas urinae hominis 6g, dracocephalum heterophyllum 25g, Herba Oxalidis Corniculatae 12g, Herba Malvastri Coromandeliani 21g, Lindernia angustifolia (Benth.) Wettst. 17g, Radix Inulae Cappae 13g, Radix araliae chinensis (Cortex Araliae Chinensis) 11g, Caulis fici pumilae (Fructus Fici Pumilae) 3g, Herba Parnassiae Wightianae 6g, Folium Malloti Apeltae 7g, Herba Physalis pubescentis 28g, Herba Blumeae Lacerae 10g, Radix Celastri Angulati 13g, Radix Acanthopanacis Trifoliati 18g, Radix Rehmanniae Preparata 21g, Fructus Lycii 30g, Flos Chrysanthemi 11g, Herba Ecliptae 16g, Ganoderma 28g, Semen Nelumbinis 22g, Herba Pimpinellae thellungianae 23g, Rhizoma pteridii latiusculi 4g, Fructus Aurantii 16g, Radix cynanchi wilfordii 15g and Plantula Excoecariae Acerifoliae 19g makes.

The dosage form of medicine is granule, and its preparation method comprises the following steps:

Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 6 times, mixture is the ethanol of 95%, be heated to boiling reflux 5 hours, filter, adopt percolation with the speed of 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 DEG C subsequently under vacuum 0.09Mpa, relative density is the mastic of 1.04, spraying dry, the inlet temperature 175 DEG C of spray dryer, leaving air temp 80 DEG C, be ground into powder subsequently, make dried cream powder;

Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 times and 0.2 times in the dried cream powder obtained, makes granule, in 50 DEG C of dryings, obtains granule.

Embodiment 3 a kind of medicine being used for the treatment of ascites of liver meridian damp-heat type bed-wetting of the present invention

By Radix Rauvolfiae 11g, Herba Inulae cappae 11g, Radix Rubiae 17g, Fructus Pyracanthae (Fructus Pyracanthae Fortuneanae) 5g, Flos Campsis 9g, calamitas urinae hominis 2g, dracocephalum heterophyllum 30g, Herba Oxalidis Corniculatae 9g, Herba Malvastri Coromandeliani 12g, Lindernia angustifolia (Benth.) Wettst. 15g, Radix Inulae Cappae 16g, Radix araliae chinensis (Cortex Araliae Chinensis) 5g, Caulis fici pumilae (Fructus Fici Pumilae) 1g, Herba Parnassiae Wightianae 12g, Folium Malloti Apeltae 11g, Herba Physalis pubescentis 23g, Herba Blumeae Lacerae 13g, Radix Celastri Angulati 16g, Radix Acanthopanacis Trifoliati 11g, Radix Rehmanniae Preparata 33g, Fructus Lycii 24g, Flos Chrysanthemi 17g, Herba Ecliptae 14g, Ganoderma 19g, Semen Nelumbinis 33g, Herba Pimpinellae thellungianae 14g, Rhizoma pteridii latiusculi 9g, Fructus Aurantii 12g, Radix cynanchi wilfordii 10g and Plantula Excoecariae Acerifoliae 10g makes.

The dosage form of medicine is honey refining pill, and its preparation method comprises the following steps:

Step 1: first Radix Rauvolfiae, Herba Inulae cappae, Radix Rubiae, Fructus Pyracanthae (Fructus Pyracanthae Fortuneanae) and Flos Campsis are mixed in described ratio, distillation crystallization obtains powder;

Step 2: get surplus stock medical material again and mix in described ratio, add 94% soak with ethanol 2 hours, the heating extraction 2 times relative to mixture 4 times amount, each 1 hour, merge extractive liquid, 150 orders filter, be the ultrafiltration post ultrafiltration of 98000 again through the molecular weight that dams, when ultrafiltrate is evaporated to 87 DEG C, relative density is the extractum of 1.04, becomes component 1;

Step 3: step 2 Chinese medicine slag is added 4 times amount water soaking 2 hours, extract 1 time, extraction time is 2 hours, and thickening filtration is extractum shape, is component 2;

Step 4: said components 1 and component 2 two kinds of extractum are condensed into pasty state, add the powder that a step obtains, add Mel and be twisted into pill.

Toxicity test:

Acute toxicity test: application NIH mice 60, SPF level, male and female half and half, body weight 17 ~ 24g, carries out acute toxicity test.Mice is divided into two groups at random, often organizes 30, i.e. matched group and administration group, fasting 12 hours before experiment; By decoction prepared by embodiments of the invention 1, (concentration is 5.74g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg(and unit dosage form is 28.7 crude drugs/kg), matched group gives normal saline, administration in a day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.The decoction LD50>28.7 crude drug/kg of Mouse oral gavage embodiments of the invention 1, every day, maximum dosage-feeding was 57.4 crude drugs/kg/ day.Chinese medicine clinical application amount of the present invention be 4.6g crude drug/day/people, adult body weight in 60KG, average dosage is 0.077g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 21g) oral administration gavage Chinese medicine of the present invention is 745 times of quantity.Therefore the Acute toxicity of the embodiment of the present invention 1 is low, clinical drug safety.

Long term toxicity test: the granule of the embodiment of the present invention 2 is pressed 6.43,15.72 and 36.41g crude drug/kg continuous use 16 weeks (1.0ml/100g body weight to mice, every day 2 times) and drug withdrawal after 4 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine preparation of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 16 weeks and drug withdrawal are after 4 weeks, and Organs of Mice is all without obviously changing.Illustrate that Chinese medicine preparation of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.

Long term toxicity test: the honey of the embodiment of the present invention 3 refining pill is pressed 6.43,15.72 and 36.41g crude drug/kg continuous use 16 weeks (1.0ml/100g body weight to mice, every day 2 times) and drug withdrawal after 4 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine preparation of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 16 weeks and drug withdrawal are after 4 weeks, and Organs of Mice is all without obviously changing.Illustrate that Chinese medicine preparation of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.

Clinical data:

Get the court in February, 2011 to 2014 year outpatient service in July and the 304 routine infants of accepting for medical treatment in hospital, in age 5-13 year, all cases all meets the diagnostic criteria of ascites of liver meridian damp-heat type bed-wetting.Man 198 example, female 106 example, what the course of disease was the shortest is 10 months, the most as long as five years, according to the principle of random controls, adopts random digits table that patient is divided into four groups at random:

Decoction treatment group: 76 people, male 50 people, female 26 people.

Granules in Treating group: 76 people, male 50 people, female 26 people.

Honey refining pill treatment group: 76, male 49 people, female 27 people.

Matched group: 76 people, male 49 people, female 27 people.

The ordinary circumstance of four groups of patients, as no difference of science of statistics such as sex, age, the courses of disease, has comparability.

Diagnostic criteria:

Western medicine diagnose standard

With reference to the diagnostic criteria of " practical paidonosology " infantile enuresis: refer to unconscious in more than 5 years old children's's nighttime sleep to urinate 1-2 time or more, know, in the daytime without urinary incontinence after awake; Look into without any neurological symptom and sign, routine urinalysis, routine blood test electroencephalogram is all normal, gets rid of because of the reason causer such as urinary tract infection, deformity, rich parasitosis, spinal cord injury, epilepsy, cerebral hypoplasia, diabetes, diabetes insipidus.Do not get rid of the person that has spina bifida occulta.

Tcm diagnosis standard:

Formulate with reference to the diagnosis basis of the enuresis in State Administration of Traditional Chinese Medicine's " Chinese medical disease Standardization of diagnosis and curative effect ": 1) age of onset is more than 5 one full year of life; 2) sleep is comparatively dark, not easily wakes up, wets the bed every night or intermittently; 3) routine urinalysis and interrupted urinary cultivate discovery how without exception; 4) x-ray takes the photograph sheet inspection, and part infant can find that there is spina bifida occulta; 5) the caused enuresis such as Nocturnal seizures, Urinary malformation, diabetes, enterobiasis, diabetes insipidus and medicine is got rid of.

Chinese medical discrimination ascites of liver meridian damp-heat type: the middle enuresis of sleeping, yellow urine is smelly, flushed face and red lips, irascible temperament, and night chews tooth, tongue fur BOHUANG, rolling pulse.

Therapeutic Method:

Decoction treatment group: take decoction prepared by the embodiment of the present invention 1, every day 1 dose, sooner or later taking for twice, 7 days is 1 course for the treatment of.

Granules in Treating group: take granule prepared by the embodiment of the present invention 2, every day 3 times, each 1 bag 7 days is 1 course for the treatment of.

Honey refining pill treatment group: take honey refining pill prepared by the embodiment of the present invention 3, every day 3 times, each 27 days is 1 course for the treatment of.

Matched group: oral contracting spring capsule (HuNan HanSen Pharmacy Co., Ltd's product), its main component has the Radix Linderae, Fructus Alpiniae Oxyphyllae, Rhizoma Dioscoreae.Specification: every 0.3g, 60 every bottle.Usage and dosage: 3 tablets/time, every day 3 times.It within 15 days, is a course for the treatment of.

Efficacy assessment standard:

Formulate with reference to " Chinese medical disease Standardization of diagnosis and curative effect ".

Recovery from illness: the not enuresis again after treatment, did not recur in half a year.

Effective: after treatment, enuresis number of times obviously reduces, occasionally there is bed wetter, can wake in sleep and urinate.

Effective: after treatment, enuresis number of times reduces.

Invalid: after treatment, the enuresis has no improvement.

Therapeutic outcome:

See table 1 and table 2, as can be seen from Table 1, adopt Drug therapy ascites of liver meridian damp-heat type bed-wetting of the present invention, relative to matched group on therapeutic effect, there is significant improvement; As can be seen from Table 2, adopt Drug therapy ascites of liver meridian damp-heat type bed-wetting of the present invention, relative to matched group, treatment the course for the treatment of on significantly shorten.

After table 1 Four composition does not treat 2 courses for the treatment of, Clinical efficacy comparison is routine

Group	Number of cases	Recovery from illness	Effective	Effectively	Invalid	Total effective rate
							Decoction treatment group	76	69	5	2	0	100%
Granules in Treating group	76	68	6	1	1	98.7%
							Honey refining pill for curing group	76	67	5	2	2	97.4%
Matched group	76	29	15	13	19	75.0%

Table 2 Four composition does not treat recovery from illness after 2 courses for the treatment of, the effective and number that takes a turn for the better and time comparative example (%)

Group	Number of cases	1st course for the treatment of	2nd course for the treatment of
				Decoction treatment group	76	59(77.6%)	17(22.4%)
Granules in Treating group	75	58(77.3%)	17(22.7%)
				Honey refining pill for curing group	74	57(77.0%)	17(23.0%)
Matched group	57	27(47.4%)	30(52.6%)

According to the clinical statistics in above table, medicine provided by the invention have rapid-action, effective percentage is high, determined curative effect, safety are high, the advantage that has no side effect.

Pay a return visit after 2 years, the nothing recurrence of decoction treatment group, Granules in Treating group, the recovery from illness of honey refining pill treatment group, 29 routine 1 case relapseds of matched group recovery from illness, relapse rate 3.4%.

Model case: grandson patient, man, 7 years old, in June, 2012 went to a doctor.The enuresis is more than 3 years.Sleep the middle enuresis, yellow urine is smelly, flushed face and red lips, irascible temperament, and night chews tooth, tongue fur BOHUANG, rolling pulse.Once arrived many hospital admissions, do not feel any better, increased the weight of on the contrary, and carried out my Out-patient Department and seek medical advice.Take the decoction of pharmaceutical preparation embodiment 1 of the present invention, every day 1 dose, sooner or later take for twice, treat and obviously improve for 4 days, continue to take medicine 3 days, enuresis transference cure, continue to take medicine to two the course for the treatment of consolidate curative effect, follow up a case by regular visits to after 2 years without recurring.

The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims (8)

1. be used for the treatment of the medicine of ascites of liver meridian damp-heat type bed-wetting, it is characterized in that, described medicine comprises following raw medicinal material: Radix Rauvolfiae, Herba Inulae cappae, Radix Rubiae, Fructus Pyracanthae (Fructus Pyracanthae Fortuneanae), Flos Campsis, calamitas urinae hominis, dracocephalum heterophyllum, Herba Oxalidis Corniculatae, Herba Malvastri Coromandeliani, Lindernia angustifolia (Benth.) Wettst., Radix Inulae Cappae, Radix araliae chinensis (Cortex Araliae Chinensis), Caulis fici pumilae (Fructus Fici Pumilae), Herba Parnassiae Wightianae, Folium Malloti Apeltae, Herba Physalis pubescentis, Herba Blumeae Lacerae, Radix Celastri Angulati, Radix Acanthopanacis Trifoliati, Radix Rehmanniae Preparata, Fructus Lycii, Flos Chrysanthemi, Herba Ecliptae, Ganoderma, Semen Nelumbinis, Herba Pimpinellae thellungianae, Rhizoma pteridii latiusculi, Fructus Aurantii, Radix cynanchi wilfordii and Plantula Excoecariae Acerifoliae.

2. medicine according to claim 1, it is characterized in that, in described medicine, the ratio of weight and number of each raw medicinal material is: Radix Rauvolfiae 6-13 part, Herba Inulae cappae 11-18 part, Radix Rubiae 13-17 part, Fructus Pyracanthae (Fructus Pyracanthae Fortuneanae) 5-11 part, Flos Campsis 3-9 part, calamitas urinae hominis 2-6 part, dracocephalum heterophyllum 20-30 part, Herba Oxalidis Corniculatae 9-13 part, Herba Malvastri Coromandeliani 12-21 part, Lindernia angustifolia (Benth.) Wettst. 10-17 part, Radix Inulae Cappae 13-21 part, Radix araliae chinensis (Cortex Araliae Chinensis) 5-11 part, Caulis fici pumilae (Fructus Fici Pumilae) 1-3 part, Herba Parnassiae Wightianae 6-15 part, Folium Malloti Apeltae 4-11 part, Herba Physalis pubescentis 16-28 part, Herba Blumeae Lacerae 8-13 part, Radix Celastri Angulati 13-17 part, Radix Acanthopanacis Trifoliati 9-18 part, Radix Rehmanniae Preparata 21-33 part, Fructus Lycii 18-30 part, Flos Chrysanthemi 11-23 part, Herba Ecliptae 14-28 part, Ganoderma 19-30 part, Semen Nelumbinis 22-36 part, Herba Pimpinellae thellungianae 12-23 part, Rhizoma pteridii latiusculi 4-9 part, Fructus Aurantii 12-18 part, Radix cynanchi wilfordii 10-17 part and Plantula Excoecariae Acerifoliae 10-21 part.

3. medicine according to claim 1 and 2, it is characterized in that, in described medicine, the ratio of weight and number of each raw medicinal material is: Radix Rauvolfiae 6 parts, Herba Inulae cappae 18 parts, 14 parts, Radix Rubiae, Fructus Pyracanthae (Fructus Pyracanthae Fortuneanae) 11 parts, Flos Campsis 4 parts, calamitas urinae hominis 5 parts, dracocephalum heterophyllum 20 parts, Herba Oxalidis Corniculatae 13 parts, Herba Malvastri Coromandeliani 18 parts, Lindernia angustifolia (Benth.) Wettst. 10 parts, Radix Inulae Cappae 21 parts, Radix araliae chinensis (Cortex Araliae Chinensis) 9 parts, Caulis fici pumilae (Fructus Fici Pumilae) 2 parts, Herba Parnassiae Wightianae 15 parts, Folium Malloti Apeltae 4 parts, Herba Physalis pubescentis 16 parts, Herba Blumeae Lacerae 8 parts, Radix Celastri Angulati 17 parts, Radix Acanthopanacis Trifoliati 9 parts, Radix Rehmanniae Preparata 30 parts, Fructus Lycii 18 parts, Flos Chrysanthemi 23 parts, Herba Ecliptae 28 parts, Ganoderma 30 parts, 36 parts, Semen Nelumbinis, Herba Pimpinellae thellungianae 12 parts, Rhizoma pteridii latiusculi 6 parts, Fructus Aurantii 18 parts, Radix cynanchi wilfordii 17 parts and Plantula Excoecariae Acerifoliae 21 parts.

4. medicine according to claim 1 and 2, it is characterized in that, in described medicine, the ratio of weight and number of each raw medicinal material is: Radix Rauvolfiae 13 parts, Herba Inulae cappae 17 parts, 13 parts, Radix Rubiae, Fructus Pyracanthae (Fructus Pyracanthae Fortuneanae) 8 parts, Flos Campsis 3 parts, calamitas urinae hominis 6 parts, dracocephalum heterophyllum 25 parts, Herba Oxalidis Corniculatae 12 parts, Herba Malvastri Coromandeliani 21 parts, Lindernia angustifolia (Benth.) Wettst. 17 parts, Radix Inulae Cappae 13 parts, Radix araliae chinensis (Cortex Araliae Chinensis) 11 parts, Caulis fici pumilae (Fructus Fici Pumilae) 3 parts, Herba Parnassiae Wightianae 6 parts, Folium Malloti Apeltae 7 parts, Herba Physalis pubescentis 28 parts, Herba Blumeae Lacerae 10 parts, Radix Celastri Angulati 13 parts, Radix Acanthopanacis Trifoliati 18 parts, Radix Rehmanniae Preparata 21 parts, Fructus Lycii 30 parts, Flos Chrysanthemi 11 parts, Herba Ecliptae 16 parts, Ganoderma 28 parts, 22 parts, Semen Nelumbinis, Herba Pimpinellae thellungianae 23 parts, Rhizoma pteridii latiusculi 4 parts, Fructus Aurantii 16 parts, Radix cynanchi wilfordii 15 parts and Plantula Excoecariae Acerifoliae 19 parts.

5. Chinese medicine according to claim 1 and 2, it is characterized in that, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Radix Rauvolfiae 11 parts, Herba Inulae cappae 11 parts, 17 parts, Radix Rubiae, Fructus Pyracanthae (Fructus Pyracanthae Fortuneanae) 5 parts, Flos Campsis 9 parts, calamitas urinae hominis 2 parts, dracocephalum heterophyllum 30 parts, Herba Oxalidis Corniculatae 9 parts, Herba Malvastri Coromandeliani 12 parts, Lindernia angustifolia (Benth.) Wettst. 15 parts, Radix Inulae Cappae 16 parts, Radix araliae chinensis (Cortex Araliae Chinensis) 5 parts, Caulis fici pumilae (Fructus Fici Pumilae) 1 part, Herba Parnassiae Wightianae 12 parts, Folium Malloti Apeltae 11 parts, Herba Physalis pubescentis 23 parts, Herba Blumeae Lacerae 13 parts, Radix Celastri Angulati 16 parts, Radix Acanthopanacis Trifoliati 11 parts, Radix Rehmanniae Preparata 33 parts, Fructus Lycii 24 parts, Flos Chrysanthemi 17 parts, Herba Ecliptae 14 parts, Ganoderma 19 parts, 33 parts, Semen Nelumbinis, Herba Pimpinellae thellungianae 14 parts, Rhizoma pteridii latiusculi 9 parts, Fructus Aurantii 12 parts, Radix cynanchi wilfordii 10 parts and Plantula Excoecariae Acerifoliae 10 parts.

6., according to the arbitrary described medicine of claim 1-5, it is characterized in that, when the dosage form of described medicine is decoction, its preparation method comprises the following steps:

Step one: purple casserole is put in described raw medicinal material mixing, adds clear water, to clear water dipped medical material upper surface 2-5cm, soak 0.5-1 hour;

Step 2: purple casserole is placed on fire, after intense fire boils, using slow fire instead, to decoct the 30-50 minute dosage to medicinal liquid be slowly 100-300ml, filters, obtain filtrate a, for subsequent use;

Step 3: residue medicinal residues are added clear water again, to clear water dipped medical material upper surface 2-3cm, soaks 1-2 hour;

Step 4: be placed in by purple casserole on fire, after intense fire boils, using slow fire instead, to decoct the 25-35 minute dosage to medicinal liquid be slowly 100-300ml, filters, obtain filtrate b, mixed by filtrate a and filtrate b.

7., according to the arbitrary described medicine of claim 1-5, it is characterized in that, when the dosage form of described medicine is granule, its preparation method comprises the following steps:

Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 4 ~ 8 times, mixture is the ethanol of 85% ~ 95%, be heated to boiling reflux 3 ~ 5 hours, filter, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.09Mpa, relative density is the mastic of 1.04 ~ 1.10, spraying dry, the inlet temperature 160 ~ 175 DEG C of spray dryer, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder;

Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 ~ 0.4 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes granule, in 40 ~ 50 DEG C of dryings, obtains granule.

8. according to the arbitrary described medicine of claim 1-5, it is characterized in that, when the dosage form of described medicine is honey refining pill, its preparation method comprises the following steps:

Step 1: first Radix Rauvolfiae, Herba Inulae cappae, Radix Rubiae, Fructus Pyracanthae (Fructus Pyracanthae Fortuneanae) and Flos Campsis are mixed in described ratio, distillation crystallization obtains powder;

Step 2: get surplus stock medical material again and mix in described ratio, add relative to 83-94% soak with ethanol 1-2 hour of mixture 2-6 times amount, heating extraction 2 times, each 1-1.5 hour, merge extractive liquid, 124-150 order filter, be the ultrafiltration post ultrafiltration of 4400-98000 again through the molecular weight that dams, when ultrafiltrate is evaporated to 87 DEG C, relative density is the extractum of 1.04, becomes component 1;

Step 3: step 2 Chinese medicine slag is added 4-6 times amount water soaking 1-2.5 hour, extract 1 time, extraction time is 1.5-2 hour, and thickening filtration is extractum shape, is component 2;

Step 4: said components 1 and component 2 two kinds of extractum are condensed into pasty state, add the powder that a step obtains, add Mel and be twisted into pill.