CN103719494A - Fructus arctii health-care tea for loosening the bowel to relieve constipation and preparation method thereof - Google Patents

Abstract

The invention provides a fructus arctii health-care tea for loosening the bowel to relieve constipation. The fructus arctii health-care tea for loosening the bowel to relieve constipation comprises the following raw materials in parts by weight: 20-50 parts of fructus arctii, 10-20 parts of Artemisia anomala, 10-20 parts of radix rehmanniae, 10-20 parts of cortex lycii radicis, 10-20 parts of angelica dahurica, 10-20 parts of poria cocos, 10-20 parts of salvia miltiorrhiza, 10-20 parts of codonopsis pilosula, 10-20 parts of perrin, 10-20 parts of gynostemma, 10-20 parts of white mulberry root-bark, 10-20 parts of trichosanthes kirilowii, 10-20 parts of coix seeds, 10-20 parts of bighead atractylodes rhizome, 10-20 parts of hawthorn, 10-20 parts of alisma, and 10-20 parts of herba patriniae. The fructus arctii is rich in greases, and smooth. Modern pharmacological researches show that the main compositions of the fructus arctii are Arctiin and fatty oil which have the effect of loosening the bowel to relieve constipation. Clinical experiences show that the fructus arctii is bitter, cold and smooth, has a strong effect of loosening the bowel to relieve constipation, therefore, for patients with constipation, the fructus arctii health-care tea can improve microcirculation, and some traditional Chinese medicines which is light in taste and does not affect the taste of the fructus arctii are added in the tea, so that the tea is easy to be accepted by people, and can achieve an effect of loosening the bowel to relieve constipation better.

Description

A kind of great burdock achene defaecation health care tea for moistening intestines and preparation method thereof

Technical field

The present invention relates to contain the defaecation ease constipation health products that derive from plant composition, particularly a kind of great burdock achene defaecation health care tea for moistening intestines and preparation method thereof.

Background technology

Constipation is the clinical common sympton of a kind of complexity of being caused by different pathological process.Traditional Chinese medicine is thought, though constipation one disease, at large intestine, all has substantial connection with internal organs channels and collaterals, qi-blood-body fluid, spiritual feelings will, is a kind of topical manifestations of yin-Yang, internal organs, qi and blood, disorder of emotion.For old and chronic habitual or the old chronic diseases marked by deficiency of vital energy constipation due to body void after being ill, the deficiency of YIN-blood of many duties, essence and blood loses flourish, and enteron aisle is dry and astringent, logically falls unfavorablely, and waste matter is not all right, causes that just to do matter hard, discharges not smooth.

Along with industrialized development, the variation of dietary structure, the improvement of living condition, constipation more and more becomes the killer of present people's health.Become the global healthy epidemic disease that has a strong impact on, therefore, the effective defaecation ease constipation of search of health method has very real significance, and the active material of defaecation ease constipation is safely and effectively that people expect the key of dealing with problems always.Defaecation ease constipation lipopenicillinase method is a lot, has dietetic treatment, kinesiatrics, medicinal treatment and clinical treatment etc.These methods more or less have weak point, and what have also easily causes side effect, as diarrhoea, apocleisis etc.And that health treatment defaecation ease constipation has is easy to use, have no side effect, the feature such as effect is remarkable, and extremely consumer's favor.

Due to the prosperity day by day of economy, the continuous lifting of modern's living standard, causes too much the having deep love for of people to be enjoyed, and does not note oneself life style, behavioural habits, diet hobby, thus the disease causing.Society with fast rhythm's life, the operating pressure of keen competition, modern's physical and mental health has been caused to serious threat, add that long-term diet is unreasonable, that is: smart grain replaces coarse food grain completely, residual agricultural chemicals, chemical fertilizer stockpiling in vivo in the absorption of three a large amount of height (high heat, high protein, higher fatty acid), more than three (anticorrisive agent is many, flavoring agent is many, hormone many) food and food, add air, pollution of waterhead and amount of exercise less than normal, go down to make enteron aisle in sub-health state for a long time like this, constipation has become the daily habits of a lot of young girls.

Great burdock achene has another name called Great Burdock Achene, FRUCTUS ARCTII, is the fruit of feverfew burdock, and annual 8～September during fruit maturation, gathers in batches, after drying, gets fruit, removes impurity, then shines to absolutely dry can being used as medicine.It is cool in nature, and taste is arduous, enters lung, stomach warp, has the effect of dispelling wind and heat from the body, a surname's lung promoting eruption, subdhing swelling and detoxicating, is used for the treatment of the diseases such as cough due to wind-heat evil, abscess of throat, macula are saturating, rubella is had an itch, carbuncle sore tumefacting virus, is that loose wind is except the key medicine of thermal detoxification.On market, have with the fruit of equal plant thistle and pretend to be certified products great burdock achene, during use, note differentiating.< < Bencao Jingshu > >: disliking in fact, is that loose wind is except the key medicine of thermal detoxification.Pungent can dissipating bind, hardship can expel the heat-evil, the loose visceral-qi of thermojunction is clear and bright, therefore improving eyesight and bowl spares.The institute of wind hinders, and defends gas and must stop up, and stops up heating, Xin Liang dismiss show gas and, wind without stay.Hide the swollen all impotences of device main air poison; The main moistening lung of element, dissipating bind gas, relieve sore throat diaphragm, peeling skin wind, logical twelve channels and collaterals person, know this meaning ear.Therefore in order to control urticaria, variola, especially obtain very and test.< < medicineization justice > >: great burdock achene can rise and can fall, power relieving heat toxin.Bitter can relieve inflammation or internal heat, be with pungent can dispelling wind, cure mainly top wind phlegm, the edema of the face, discomfort in the throat, all scorchingly hot heap soil or fertilizer over and around the rootss, sabre scrofula, neck subcutaneous nodule, blood-head acne, time row measles, urticaria, all lung channel stagnated fire, wind and heat in the lung meridian, knows and should use this.The < < book on Chinese herbal medicine > > that looks for the truth: great burdock achene, only speech removing toxic substances of moderns, the diseases such as all chance sore carbuncles are swollen, acne rash, control with this throwing invariably, so still do not unravel silk its justice.The knot of ordinary person's poison gas, many edge are caught cold, and the stagnation of ying-qi is contrary in meat, therefore raw carbuncle poison.Burdock taste is pungent and bitter, can sending down abnormally ascending descending, and the reactivation wind heat extraction that falls apart is to experience ailment said due to cold or exposure heat poison and see the edema of the face, and cough phlegm is stopped up, and between pharynx, swells and ache, and sore macula, and the disease such as all smelly poison, acute diseases such as cholera and sunstroke close, variola purple is black, just close, show Xie Liqing invariably whereby.But the cold sliding profit of property, many clothes middle gas damage, and more order table benefit is empty.As for splenasthenic diarrhea for here especially avoiding.

The fiber of burdock can promote intestinal peristalsis, helps defecation, reduces body inner cholesterol, and minimizing toxin, refuse accumulate in vivo, reaches prevention of stroke and the effect of preventing and treating cancer of the stomach, the cancer of the uterus.Often edible radix bardanae stimulates circulation, thus be applicable to very much the working clan of long-term sitting office, but burdock is very strong base-forming food, suffers from the people of contact dermatitis or eczema, preferably uses less.Remove stomach rubbish, prevent that human body from crossing presenility, moist skin, preventing apoplexy and hypertension, detoxicating intestine, reduction cholesterol and blood sugar, and applicable diabetic eats (because containing synanthrin in radix bardanae) for a long time, rheumatoid disease, antimycotic have a certain curative effect, cancer and uremia are also had to good prevention and inhibitory action, therefore be described as the best hematocathartic of the Nature, Taiwan among the people using burdock as kidney tonifying, the holy product of establishing-Yang, nourishing.

The various defaecation ease constipation health products of selling on the market now, dragons and fishes jumbled together for medicine, great majority are simple cathartic, allow people dewater in a large number, cause the huge injury of the person, therefore, the effective defaecation ease constipation of search of health method has very real significance, and the active material of defaecation ease constipation is safely and effectively the key that people expect to solve problem of obesity always.Chinese medicine defaecation ease constipation, have advantages of nontoxic, can be absorbed completely by organism, be the main direction that we study.Now market is in the urgent need to developing a kind of have defaecation ease constipation fat-reducing, antioxidation, and can interference body to fatty absorption, the defaecation ease constipation product that the fat that promotes to take in excretes, and have advantages of nontoxic, can be absorbed completely by organism.

Summary of the invention

Technical problem to be solved by this invention is, dragons and fishes jumbled together for most of defaecation ease constipation products in market now, the overwhelming majority is simple cathartic, allow people dewater in a large number, can cause huge injury to the person, therefore, the effective defaecation ease constipation of search of health method has very real significance, and the active material of defaecation ease constipation is safely and effectively the key that people expect to solve constipation problem always.Great burdock achene is rich in grease, and property is slided profit more.Modern pharmacological research shows, burdock main component is arctiin and fat oil, and these compositions have the merit of defaecation ease constipation.Clinical experience, the great burdock achene cold cunning of working hard, the logical lower effect of laxation is stronger, thus the Gospel to constipation patient can be improved microcirculation, adds some mouthfeels light, does not affect the Chinese medicine of great burdock achene taste, makes people be easy to accept, and can reach preferably the effect of defaecation ease constipation.

For solving above-mentioned technical barrier, the invention provides a kind of great burdock achene defaecation health care tea for moistening intestines, in described great burdock achene defaecation health care tea for moistening intestines, the parts by weight of various raw materials are: 20～50 parts of great burdock achenes, 10～20 parts of Artemisia anomalas, 10～20 parts, the dried rhizome of rehmannia, 10～20 parts of the root barks of Chinese wolf-berry, 10～20 parts of the roots of Dahurain angelica, 10～20 parts, Poria cocos, 10～20 parts of the reds sage root, 10～20 parts of Radix Codonopsis, 10～20 parts of eupatoriums, 10～20 parts of gynostemma pentaphylla, 10～20 parts of the root barks of white mulberry, 10～20 parts of snakegourds, 10～20 parts of heart of a lotus seed benevolence, 10～20 parts of the bighead atractylodes rhizomes, 10～20 parts of hawthorn, 10～20 parts of rhizoma alismatis, 10～20 parts of field pennycress.

Described great burdock achene defaecation ease constipation Antilipemic health tea, described in it, in great burdock achene defaecation ease constipation Antilipemic health tea, the parts by weight of various raw materials can be: 20～30 parts of great burdock achenes, 10～15 parts of Artemisia anomalas, 10～15 parts, the dried rhizome of rehmannia, 10～15 parts of the root barks of Chinese wolf-berry, 10～15 parts of the roots of Dahurain angelica, 10～15 parts, Poria cocos, 10～15 parts of the reds sage root, 10～20 parts of Radix Codonopsis, 10～20 parts of eupatoriums, 10～20 parts of gynostemma pentaphylla, 10～20 parts of the root barks of white mulberry, 10～20 parts of snakegourds, 10～20 parts of heart of a lotus seed benevolence, 10～20 parts of the bighead atractylodes rhizomes, 10～20 parts of hawthorn, 10～20 parts of rhizoma alismatis, 10～20 parts of field pennycress.

Described great burdock achene defaecation health care tea for moistening intestines, described in it, in great burdock achene defaecation health care tea for moistening intestines, the parts by weight of various raw materials can also compare: 20～40 parts of great burdock achenes, 10～20 parts of Artemisia anomalas, 10～20 parts, the dried rhizome of rehmannia, 10～20 parts of the root barks of Chinese wolf-berry, 10～20 parts of the roots of Dahurain angelica, 10～20 parts, Poria cocos, 10～20 parts of the reds sage root, 10～15 parts of Radix Codonopsis, 10～15 parts of eupatoriums, 10～15 parts of gynostemma pentaphylla, 10～15 parts of the root barks of white mulberry, 10～15 parts of snakegourds, 10～15 parts of heart of a lotus seed benevolence, 10～15 parts of the bighead atractylodes rhizomes, 10～15 parts of hawthorn, 10～15 parts of rhizoma alismatis, 10～15 parts of field pennycress.

For solving the problems of the technologies described above, the present invention also provides a kind of preparation method of great burdock achene defaecation health care tea for moistening intestines, and the preparation process of described great burdock achene defaecation health care tea for moistening intestines comprises following aspect:

A. the preparation of great burdock achene;

B. by described other raw material pulverizing, immersion, heating, refluxing extraction 2 times;

C. the liquid again surplus stock being extracted is condensed into granule, pulvis or paste;

D. concentrated granule, pulvis or paste are mixed with the great burdock achene preparing, be prepared into health care medicinal tea.

In described step a, can get the great burdock achene obtaining and clean, the airing time, at 7-12 hour, parches; The good great burdock achene of airing is put into the pot that completes and go green grass or young crops, the 30-45 minute that completes at 80-100 ℃, then puts into large iron pan and stir-fries, first downwards backward upper, firmly wants evenly, when great burdock achene color starts jaundice, starts the moulding in 30-45 minute that stir-fries of little fire; When color becomes pitchy, after taking out, naturally dry.

In described step b, surplus stock can be cleaned to impurity elimination, dry, be ground into particle, soak 1 hour; Soaked raw material is put to boiling secondary in multi-function extractor; Add up for the first time the water of 10 times of amounts of medicinal material, decoct 1.5～2 hours, get decocting liquid, filter; The water that adds for the second time 7 times of amounts of total amount, decocts 1～1.2 hour, gets twice decocting liquid and mixes, and filters.

In described step c, the filtrate of filtration can be inserted in economic benefits and social benefits vacuum concentrator to the concentrate that while being concentrated into 90 ℃, relative density is 1.05, set to 0～5 ℃ of deepfreezes 24 hours; Refrigeration liquid is added to 0.3% filter aid diatomite, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 1g crude drug amount, then adds dextrin and puts into granulator and granulate.

In described steps d, the particle that the good great burdock achene of frying can be prepared with surplus stock mixes, and ultraviolet disinfection, packs and get final product.

For solving the problems of the technologies described above, the present invention provides a kind of preparation method of great burdock achene defaecation health care tea for moistening intestines again, when other raw materials of described great burdock achene defaecation health care tea for moistening intestines are made pulvis, step is: other raw materials are put into 10 times of amount ethanol, heating and refluxing extraction 2 times, each 1～2 hour, No. 2 extracts are merged standing; The dregs of a decoction of the component raw medicinal material of more above-mentioned alcohol extract being crossed add 10 times of water gaging heating and refluxing extraction 2 times, each 1～2 hour, No. 2 extracts are merged standing; Above-mentioned two kinds of extracts are merged, and reclaiming after ethanol decompression, to put into inspissator concentrated, then puts into drying baker and be dried into powder, after ultraviolet radiation for sterilizing and disinfecting, merges packing with the good great burdock achene of frying.

The preparation method of described great burdock achene defaecation ease constipation Antilipemic health tea, in above-mentioned concentration step, two kinds of extracts are merged, after recovery ethanol, reducing pressure, it is concentrated to put into inspissator, the concentrate that while being concentrated into 90 ℃, relative density is 1.05, set to 0～5 ℃ of deepfreezes 24 hours; Refrigeration liquid is added to 0.3% filter aid diatomite, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 1g crude drug amount.

The technique effect that the present invention is useful is, that the present invention has advantages of is nontoxic, can be absorbed completely by organism.Great burdock achene is rich in grease, and property is slided profit more.Modern pharmacological research shows, burdock main component is arctiin and fat oil, and these compositions have the merit of defaecation ease constipation.Clinical experience, the great burdock achene cold cunning of working hard, the logical lower effect of laxation is stronger, thus the Gospel to constipation patient can be improved microcirculation, adds some mouthfeels light, does not affect the Chinese medicine of great burdock achene taste, makes people be easy to accept, and can reach preferably the effect of defaecation ease constipation.

The specific embodiment

The just > > of < < book on Chinese herbal medicine: the use of burdock, energy dispelling wind and heat from the body, rises and sends out an acne rash, and kind logical stool, Gou Feire contains, or the not solid person of temper, that throws often has loose bowels, and the pungent hardship of letting out is fallen, and descending power is many.The clean ancient temperature of doing, Jing Yue calls again it has liter, all non-true essence in falling.< < does not record > > and claims its improving eyesight, and wind-heat is let out and order is self-evident.Bowl spares person, also Xing's heat is gone and is just certainly pacified.Except wind the wounded, with wind-heat speech also.Its rhizome, be on the point of the bitter cold of lake < < detailed outline > > meaning, < < does not record > > and cures mainly, all the meaning of heat extraction tonneau.Cover its power, this is close with son, and the property of cold and cool catharsis is crossed it, all with heat-clearing, lets out and leads as controlling, and all non-excess fires, cannot not absurdly throw.Being suitable for of all lung heresies reaches, but and be unsuitable for the person of falling, as measles from the beginning of, still do not give vent to, early throw and fall clearly, perseverance has the mechanism of qi of suppressing, the anxiety that renvoi caves in.Among only burdock is let out clearly, self energy is sent out thoroughly, and warm disease, and stool, from logical, also can kill its gesture less, therefore the burdock the most special medicine of measles.Great burdock achene is rich in linoleic acid, rutin, Quercetin, phytosterol, selenium, chromium, manganese.Can alleviate the pathologic lesion to acute pancreatitis; protection pancreatic tissue; strengthen insulin peripheral action; anti peroxidation of lipid; suppress oxidative modification of high density lipoprotein, promote that cholesterol degradation is cholic acid excretion, reduces the permeability of capillary; hemangiectasis, strengthens ascorbic effect and promotes vitamin accumulating in vivo.

From the flavor efficacy analysis of great burdock achene, its defaecation ease constipation mechanism relates generally to following three aspects:.One, ease constipation.Great burdock achene is the seed of burdock, is rich in grease, and property is slided profit more.Modern pharmacological research shows, burdock main component is arctiin and fat oil, and these compositions have the merit of the ease constipation of relaxing bowel.Clinical experience, the great burdock achene cold cunning of working hard, the logical lower effect of laxation is stronger, thus to constipation patient, the genus of house rheum officinale, saltcake, numb benevolence, and reuse separately great burdock achene 24g, aobvious this meaning of residence.Its two, lung qi falls.The lung is concerned with QI of the whole body, forming an integral part with large intestine.Logical the falling of intestines internal organs, depends on a surname of lung qi respectful.It is respectful that lung loses a surname, and large intestine promotion is unable, causes FU QI being obstructed.Therefore lung must be first controlled in defaecation ease constipation.Great burdock achene enters lung channel, can fall lung qi.As Zhang Xichun cloud: " the contrary of lung qi can fall in great burdock achene " " perillaseed, burdock again clearly phlegm fall contraryly, make contrary cyclostrophic and descending " (< < Records of Tradition Chinese and Western Medicine in Combination > >).With its defaecation ease constipation, there is the wonderful of " carry kettle and take off lid ".Its three, stomach Qi is fallen.Defeated large intestine under the descending swill of stomach Qi, then becomes stool and excretes.Great burdock achene enters stomach warp, and stomach Qi, can fall in " the pungent hardship of rushing down is fallen, and descending power is many " (the just > > of < < book on Chinese herbal medicine), has the effect of medicine for stomach dynamic.As Zhang Xichun cloud: " ... therefore help it to fall the medicine of stomach again, ochre, dried orange peel, burdock in side are also " (< < Records of Tradition Chinese and Western Medicine in Combination > >).In a word, great burdock achene is cold in nature, and taste is arduous.The heat-clearing of cold energy, under hardship can be rushed down, Xin Nenghang is loose, is applicable to the malicious Tianjin of various heat and hinders constipation.As < < medicineization justice > > cloud: " great burdock achene can rise and can fall, power relieving heat toxin, and bitter can relieve inflammation or internal heat, and is with pungent energy dispelling wind, cures mainly ... all scorchingly hot heap soil or fertilizer over and around the rootss ... ".

All on the books to great burdock achene in < < Chinese medicine voluminous dictionary > > and pertinent literature: can calm the nerves, the swollen wind pain of lively atmosphere blood, the wide intestines of sending down abnormally ascending, heat-clearing, long-pendingization of dispelling are stagnant, gut purge, ease constipation, defaecation ease constipation, cough-relieving, relieving asthma, the effect such as anti-inflammatory, antiallergy, cardiac stimulant, defaecation ease constipation, beauty treatment.Great burdock achene--seven major nutrient complete set, is not medicine, is not health products, is to work as the food that meal is eaten, and but has remarkable healthy nutritive value and outstanding dietotherapy effect.Great burdock achene is rich in grease, and property is slided profit more.Modern pharmacological research shows, burdock main component is arctiin and fat oil, and these compositions have the merit of defaecation ease constipation.Clinical experience, the great burdock achene cold cunning of working hard, the logical lower effect of laxation is stronger, thereby to constipation patient, can improve microcirculation, adds that some mouthfeels are light, does not affect the Chinese medicine of great burdock achene taste, makes people be easy to accept, and can reach preferably the effect of defaecation ease constipation.

Radix Codonopsis is the conventional traditional tonic of China, take Radix Codonopsis that area, Shangdang, Shanxi produces ancient times as top grade, has tonifying middle-Jiao and Qi, the effect of invigorating the spleen benefit lung.Modern study, Radix Codonopsis, containing various saccharides, phenols, sterol, volatile oil, scutellarein glucosid, saponin and Alkaloid, has immunity, hemangiectasis, the step-down of enhancing, improves microcirculation, strengthens the effects such as hematopoiesis function.In addition leucocyte chemotherapy radiotherapy being caused declines castering action.Radix Codonopsis has tonifying middle-Jiao and Qi, the effect of invigorating the spleen benefit lung.For a little less than the spleen deficiency syndrome of the lung, the palpitaition of breathing hard, anorexia and loose stool, void is breathed with cough and is coughed, and interior heat is quenched one's thirst etc.< < new compilation of materia medica > > records: " tonifying middle-Jiao and Qi and taste, relieving thirst and restlessness.Middle gas is faint, in order to adjust, mends, very smooth and proper.”

Gynostemma pentaphylla is found through modern medicine study, the main active ingredient of gynostemma pentaphylla is polysaccharide, flavonoids, saponins and microelement kind, its effect is mainly to promote body fat class metabolism, nutrition human body cell, there is good detoxicating, relieving inflammation effect simultaneously, be widely used in treatment and the health care of high fat of blood, fatty liver, obesity, constipation, insomnia, hepatitis B, chronic respiratory inflammation (sphagitis, enterogastritis etc.).

Poria cocos taste is sweet, light, property is flat, be used as medicine there is clearing damp and promoting diuresis, the function of beneficial spleen and stomach, antitoxic heart-soothing and sedative.Modern medicine study: Poria cocos energy enhanced machine body immunity function, pachymaran has significantly antitumor and protect the liver dirty effect.Poria cocos slightly sweet flavor is flat, enters the heart, lung, the spleen channel.There is eliminating dampness and diuresis, strengthening the spleen and stomach, the effect of antitoxic heart-soothing and sedative.Can control difficult urination, oedema turgor, phlegm and retained fluid is coughed contrary, vomits contrary, and vomiting during early pregnancy, has loose bowels, seminal emission, stranguria with turbid discharge, palpitation with fear, forgetful disease such as grade.The Li Shui of Poria cocos, reaches by strong fortune spleen PFT, different from the Chinese medicine of other direct Li Shui.For splenasthenic diarrhea, the lower Poria cocos of band can invigorating the spleen, again can excreting dampness, and due to insufficiency of the spleen dysfunction of the spleen in transportation and transformation, to have loose bowels, be with down, application Poria cocos has the effect of giving consideration to both the incidental and fundamental, the compatibilities such as normal and Radix Codonopsis, the bighead atractylodes rhizome, Chinese yam.Can be used as tonifying lung spleen, control the adjuvant of the deficiency of vital energy.

Eupatorium expelling summer-heat and damp, ward off dirty and in.Cure mainly and experience summer-heat and damp; Fever and chills headache; In moistening, accumulate; Gastral cavity ruffian is not hungry; N and V; Sweet greasy in mouthful; Disappear truly. < < Bencao Jingshu > >: lung governing qi, lung qi pent-up, upper orifices is closed and lower orifices are obstructed, the main Na Shuigu of stomach, stagnation of stomach-QI, when water paddy not take, be phlegm addiction, the pungent flat energy dissipating bind of fragrant thoroughwort is stagnant, and fragrance can remove dirty evil, come up all cards from recover, mostly appetizing removes and dislikes, clearing lung-heat dissolving phlegm, and the panacea of Disperse hepatic depression is also.< < key medicine is divided agent > >: fragrant thoroughwort, for the product of dissolving phlegm except the Yu Xiejie that dislikes, falls apart, through the > > treating with Herba EuPatorii of quenching one's thirst, removing the accumulation of stale pathogen also in < <.Lid is quenched one's thirst by heat symptoms caused by an exopathgen pent-up in stomach, blue can removing the accumulation of stale pathogen.Known fragrant thoroughwort admittedly be take and cleanses as merit, eliminates stomach person also.

Heart of a lotus seed benevolence is conventional Chinese medicine. be again generally, the food often eaten, property slightly sweet flavor is slightly cold, and has that inducing diuresis for removing edema, invigorating the spleen are dried, relaxing muscles and tendons is except effects such as numbness, clearing away heat and eliminating pus, is conventional damp-clearing drug.Heart of a lotus seed benevolence is again a kind of beauty food, and normal food can keep human body skin gloss fine and smooth, eliminates acne, spot sparrow, senile plaque expelling, cyasma, butterfly macules, to furfur, acne, chap, pachylosis etc. has good efficacy.The kind Renhe root of the seed of Job's tears can be used as medicine and cure the disease again.Li Shizhen (1518-1593 A.D.) is recorded in < < Compendium of Materia Medica > >: " invigorating spleen and reinforcing stomach, tonifying lung heat-clearing, removes wind prevailing over dampness to seed of Job's tears energy.The food of cooking a meal, controls cold air.Decoct drink, diuresis heat is drenched." in recent years, a large amount of scientific research and clinical practices prove, the seed of Job's tears or a kind of cancer therapy drug, and Preliminary Identification, it can reach more than 35% the inhibiting rate of cancer.

Bighead atractylodes rhizome bitter, sweet, temperature.Return spleen, stomach warp.Cure mainly strengthening the spleen and replenishing qi, eliminating dampness Li Shui, hidroschesis, antiabortive.Few for insufficiency of the spleen food, abdominal distension is had loose bowels, and phlegm and retained fluid is dizzy throbs with fear, oedema, spontaneous perspiration, fetal irritability.The bighead atractylodes rhizome has CDCC to oncocyte, can reduce the rate of increase of oncocyte, lowers the aggressive of tumor tissue, improves the ability of the antitumor reaction of body.Baizhu volatile oil has inhibitory action to mouse EC, lymphosarcoma ascitic type, the cancer of the esophagus (Ecal09), sarcoma 180 etc.Atractylodes lactone B lumbar injection is to the murine sarcoma people.Also there is remarkable inhibitory action.< < property of medicine opinion > > carries it: monarch, taste is sweet, pungent, nontoxic.Can main large wandering arthritis, diarrhea due to disorder of qi for many years, trusted subordinate's distending pain, the broken place food that disappears, appetizing, removes sputum, except fever and chills, lets out under only.Interarea light is happy, preserves youthful looks, and de-black.The swelling of harnessing the river is full, tells to vomit contraryly, and crymodynia in abdomen, vomits and diarrhoea incessantly, and the cold dysentery of stomach Qi deficiency.

The red sage root is bitter, is slightly cold.The thoughts of returning home, Liver Channel.Stasis-dispelling and pain-killing, activating blood to promote menstruation, relieving restlessness clears away heart-fire.For irregular menstruation, through closing dysmenorrhoea, a lump in the abdomen causing distension and pain, chest ventral spine pain, and hot numbness pain, sore swells and ache, dysphoria and insomnia.For sternal rib hypochondriac pain, arthralgia due to wind-dampness, abdominal mass caking, sore swells and ache, fall fall forward grieved, irregular menstruation, through closing dysmenorrhoea, postpartum stasis of blood pain etc.Treatment sternal rib pain, abdominal mass caking, and irregular menstruation, through amenorrhoea, bitterly there is good effect.< < detailed outline > > carries: the red sage root, press the sensible opinion of < < married woman > > cloud, Siwu Tang is controlled gynecopathy, pay no attention to antenatal postpartum, how many through water, all can be general, the only taste red sage root is loose, cures mainly identical with it.The lid red sage root can break place blood, mends new blood, peaceful tire, the stillborn foetus that falls, stop metrorrhagia stagnant under, menstruation regulating arteries and veins.Main Compositions of Radix Salviae Miltiorrhizae tanshinone has hemangiectasis, improves circulation, removes the effects such as intravascular coagulation, has the effect of invigorating blood circulation trace, and can promote liver blood circulation, is beneficial to liver cell regeneration.

The dried rhizome of rehmannia: the dried rhizome of rehmannia is also radix rehmanniae recen, the fresh or dry piece root of Scrophulariaceae herbaceos perennial glutinous rehmannia Rehmannia glutinosa Libosch..Heat-clearing, promote the production of body fluid, moisturize, laxation, the broken stasis of blood, raw new, pain relieving, menstruation regulating, the metal-inflicted wound stasis of blood, cool blood, hemostasis; The effect of fresh rehmannia root and radix rehmanniae recen is different.Fresh rehmannia root clearing heat and promoting fluid, can stop blooding and cool blood, is often for consumption of YIN caused by febrile disease, the illnesss such as haematemesis, abscess of throat, the deep red polydipsia of tongue, a spot dermexanthesis and nosebleed heat.With respect to fresh rehmannia root, radix rehmanniae recen is heat clearing and blood cooling, also can promote the production of body fluid, and all right yin-nourishing is used for treating yin asthenia generating intrinsic heat, hectic fever due to yin labor heat, the deep red polydipsia of tongue, sends out the problems such as spot dermexanthesis.The dried rhizome of rehmannia is cold in nature, and function is enriching yin and nourishing kidney.Not only promote the production of body fluid to quench thirst and heat clearing and blood cooling, also to metrorrhagia, irregular menstruation, fetal irritability, constipation etc., have effect, every blood system to have the people of thermal burn the moon, can often take.If want to treat warm heat disease, can do qingying decoction with the dried rhizome of rehmannia; If the later stage for the treatment of warm disease, because She's heat does not also disappear to the greatest extent, should be used for boiling Qinghao Biejia Tang the dried rhizome of rehmannia; In addition, for blood-head poison, contain, macula purple is black, and the serious heat of warm heat disease enters the symptom of ying blood, can take the Sisheng Wan that the dried rhizome of rehmannia is made; The general nourishing Yin and promoting production of body fluid of wanting treats that interior heat quenches one's thirst with constipation, should eat the once liquid soup that the dried rhizome of rehmannia boils.

The root bark of white mulberry is the root skin of moraceae plants mulberry Morus alba L..Main product in Anhui, the ground such as Henan, Zhejiang, Jiangsu, Hunan.Effect: removing heat from lung and relieving asthma, inducing diuresis for removing edema.For lung heat, cough and breathe heavily, the edema of the face, the diseases such as difficult urination.< < property of medicine opinion > >: make, flat.Can control lung qi and breathe heavily completely, aqueous vapor edema, main wound is exhausted, dredging water passages, the aqueous vapor that disappears, the headache of consumptive disease visitor heat, interior tonifying for the deficiency.< < Japan hanako materia medica > >: temperature, in tune, lower gas.Dissolving phlegm is quenched the thirst, sharp intestine and small intestine, and appetizing, lower food, kills abdomen and hides worm, and only cholera is vomited and diarrhoea.

Hawthorn, containing multivitamin, crataegolic acid, tartaric acid, citric acid, malic acid etc., also contains the mineral matters such as flavonoids, lactone, carbohydrate, protein, fat and calcium, phosphorus, iron, and contained lipolytic enzyme can promote the digestion of fat food.Promote gastric secretion and increase the functions such as stomach endoenzyme element.The traditional Chinese medical science thinks, hawthorn has that long-pendingization of disappearing is stagnant, convergence only dysentery, the effect such as activate blood circulation and disperse blood clots.Cure mainly the diseases such as eating accumulation, chest diaphragm ruffian are full, the amenorrhoea of hernia blood stasis.In hawthorn, contain the drug ingedients such as mountain terpene and brass class, there is significant hemangiectasis and hypotensive effect, there is the function that strengthens cardiac muscle, arrhythmia, adjusting blood fat and cholesterol level, hawthorn has the effect activating blood circulation and dispersing blood clots, contribute to remove local extravasated blood state, traumatic injury is had to auxiliary curative effect; The generation of free radical is blocked and reduced to the substances such as the flavonoids that hawthorn is contained and vitamin C, carrotene, can strengthen the immunity of body, has anti-aging, anticancer effect; In hawthorn, having relievings asthma reduces phlegm, the composition of anti-bacteria, treatment abdominal pain diarrhea.

Cogongrass rhizome cures mainly: cooling blood and hemostasis, and clearing heat and detoxicating.For spitting blood, hematuria, heat is drenched, oedema, jaundice, difficult urination, pyreticosis polydipsia, the stomach energy sound of vomiting of vomitting, coughs.< < herbal classic > >: " main internal lesion caused by overexertion void is thin, and tonifying middle-Jiao and Qi, except hemostasis, blood close fever and chills, diuresis." < < does not record > >: " lower five drenched, except visitor's heat is at stomach, quench the thirst, and hard muscle, married woman's metrorrhagia.", the just > > of < < book on Chinese herbal medicine: cogongrass rhizome, cold and cool and taste is very sweet, the heat that can purify the blood minute; and do not hinder dry; not sticky again, therefore cool blood and do not consider its long-pending stasis of blood is told nosebleed spitting blood to lead.Drop-down fire is contrary, and its effect is very prompt, therefore main stomach fire hiccup vomiting again, the lung heat circulation of vital energy in the wrong direction is breathed heavily full.And sweet cold and greasiness liquid, differs from bitter dryly though fall contrary, slakes thirst and help produce saliva again, and washs clearly the latent heat between lung stomach and intestine, can treat the paddy that disappears dry yearningly.Again can treating stranguria closing and control blood under haematuria, and housewife female's blood-heat bleeding, metrorrhagia is drenched band.The little water of tonneau again, the oedema of the knot that expels the heat-evil, leads the jaundice of stagnant heat, all sweet cold actual effect of removing heat by catharsis.So its sweet cold power, lets out clearly lung stomach, especially has speciality, and all dentalgia gums are swollen, and all sores of noma dispute, and the rotten all cards of the strongly fragrant pharyngalgia of stopping up of lung heat, make in order to assistant, and effect is the most outstanding, and without abuses.

The root bark of Chinese wolf-berry is cold in nature, and taste is sweet.Cool blood is except steaming, and fire falls in clearing lung-heat.For deficiency of Yin hectic fever, hectic fever due to yin night sweat, cough with lung heat, spitting of blood, bleeding from five sense organs or subcutaneous tissue.< < does not record > >: " main air is wet, lower breast side of body gas, the headache of visitor's heat, mends internal injury great Lao suctions of hissing, hard muscle, reinforcing yin essence, sharp intestine and small intestine, heat resists cold.″

It has the hemostasis of curing the wound Artemisia anomala, and broken blood stimulates the menstrual flow, promoting digestion and removing indigestion, the effect of the appetizing of being amusing.It can be used for acute icteric hepatitis, toothache, chronic bronchitis, stomatitis, sphagitis, tonsillitis, ephritis, malaria; Eye conjunctivitis is controlled in external application, tympanitis, sore, eczema, traumatism and bleeding.Broken blood stimulates the menstrual flow, healing up sore and subduing swelling.Control through closing abdominal mass, chest and abdomen swelling and pain, postpartum blood stasis, traumatic injury, metal-inflicted wound is hemorrhage, Yong Du inflammation is swollen.< < Tang materia medica > >: " main broken blood is lower swollen." < < Japan hanako materia medica > >: " controls pain in the chest and abdomen, and lower air water is swollen, vim and vigour, logical married woman's passages through which vital energy circulates crux, only cholera watery diarrhea.

Root of Dahurain angelica meridian distribution of property and flavor: pungent, temperature.Attach to the lung and stomach meridians.Expelling wind and clearing away cold, understand things pain-stopping, detumescence and apocenosis, eliminating dampness is band only.Expelling wind and clearing away cold, understand things pain-stopping, the apocenosis of invigorating blood circulation, myogenic pain relieving, eliminating dampness is band only.For headache, toothache, nasosinusitis, intestines wind anal fistula, leukorrhea with reddish discharge, ulcer sores, pruitus.The modern pharmacological research proof root of Dahurain angelica also has the effects such as anti-inflammatory, antipyretic-antalgic.Root of Dahurain angelica external application is beauty treatment key medicine.The < < Compendium of Materia Medica > > meaning root of Dahurain angelica " longue skin, moist color, can make face fat ", in ancient times beauty treatment sides multiplex it.

Snakegourd: latin name: Trichosanthes kirilowii Maxim.Another name Snakegourd Fruit.Fruit medicine claims whole Fructus Trichosanthis, the fruit-rind of Chinese trichosanthes, the seed title semen trichosanthis that is used as medicine, the piece root title root of Chinese trichosanthes that is used as medicine.Fruit is containing saponin, organic acid, fatty wet goods.Taste is sweet, cold in nature.Have that moistening lung is eliminated the phlegm, the wide chest effect of sharp gas.Treatment cough with ropy sputum, uncomfortable in chestly has a pain.Snakegourd preparation is controlled coronary disease and angina pectoris certain curative effect.Moistening lung, reduces phlegm, dissipating bind, ease constipation.Control phlegm-heat cough, the obstruction of qi in the chest, accumulation of pathogens in chest, consumptive lung disease hemoptysis, quenches one's thirst, jaundice, constipation, carbuncle swollen from the beginning of.< < detailed outline > >: " moistening lung is dry, falls fire.Control cough, wash phlegm knot, throat, subduing inflammation sore.”

Rhizoma alismatis, theory of traditional Chinese medical science thinks that it is cold in nature, has the effect of clearing damp and promoting diuresis.Modern medicine study, rhizoma alismatis can reduce serum total cholesterol and triacylglycerol content, slows down atherogenesis; Rhizoma alismatis and preparation modern times thereof are also used for the treatment of auditory vertigo, dyslipidemia, seminal emission, fatty liver and diabetes etc.

Field pennycress returns liver, stomach, large intestine channel.Clearing heat and detoxicating, cool blood, the carbuncle that disappears apocenosis, stasis-dispelling and pain-killing.Cure mainly: for acute appendicitis, the high heat of lung carbuncle, coughs vomiting of pus and blood, hot carbuncle malignant boil, sore furuncle is bitterly swollen, chest abdomen pain, appendicitis, enteritis, dysentery, postpartum abdominal pain, dysmenorrhoea.Field pennycress is the whole herb with root of Valerianaceae herbaceous plant chrysanthemum and patrima villosa.< < Sheng Nong's herbal classic > > classifies as top grade, is conventional heat-clearing and detoxifying drug.Its nature and flavor are pungent, bitter, be slightly cold, and have the merit of clearing heat and detoxicating, the carbuncle that disappears apocenosis, stasis-dispelling and pain-killing.Custom be used for the treatment of acute appendicitis (appendicitis), lung carbuncle (lung abscess), carbuncle sore tumefacting virus and postpartum the disease such as stasis blocking stomachache, 6～15 grams of usual amounts.By clinical verification, these product also have many new functions.

Specific embodiment 1:

First, by great burdock achene preparation, stir-fry.

Again by all the other raw material great burdock achenes, Artemisia anomala, the dried rhizome of rehmannia, the root bark of Chinese wolf-berry, the root of Dahurain angelica, Poria cocos, the red sage root, Radix Codonopsis, eupatorium, gynostemma pentaphylla, the root bark of white mulberry, snakegourd, heart of a lotus seed benevolence, the bighead atractylodes rhizome, hawthorn, rhizoma alismatis, field pennycress, extracts concentrated granulation agent, pulvis or paste.

The great burdock achene that mixing has been fried and the extract of other raw materials, ultraviolet radiation for sterilizing and disinfecting pack, directly can take after mixing it with hot water during use.

Specific embodiment 2:

Get great burdock achene 5000g and clean, the airing time, at 7-12 hour, parches; The good great burdock achene of airing is put into the pot that completes and go green grass or young crops, the 30-45 minute that completes at 80-100 ℃, then puts into large iron pan and stir-fries, first downwards backward upper, firmly wants evenly, when great burdock achene color starts blackout, starts the moulding in 30-45 minute that stir-fries of little fire; When color becomes pitchy, after taking out, naturally dry; By surplus stock Artemisia anomala 1200g, dried rhizome of rehmannia 1000g, root bark of Chinese wolf-berry 1000g, root of Dahurain angelica 1200g, Poria cocos 1000g, red sage root 1000g, Radix Codonopsis 1000g, eupatorium 1000g, gynostemma pentaphylla 1000g, root bark of white mulberry 1300g, snakegourd 1000g, heart of a lotus seed benevolence 1200g, bighead atractylodes rhizome 1000g, hawthorn 1300g, rhizoma alismatis 1000g, field pennycress 1200g, cleans impurity elimination, dry, be ground into particle, soak 1 hour; Soaked bulk drug is put to boiling secondary in multi-function extractor; Add up for the first time the water of 10 times of amounts of medicinal material, decoct 1.5～2 hours, get decocting liquid, filter; Add up for the second time the water of 7 times of amounts of medicinal material, decoct 1～1.2 hour, get twice decocting liquid and mix, filter; The filtrate of filtration is inserted in economic benefits and social benefits vacuum concentrator to the concentrate that while being concentrated into 90 ℃, relative density is 1.05, set to 0～5 ℃ of deepfreezes 24 hours; Refrigeration liquid is added to 0.3% filter aid diatomite, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 1g crude drug amount, adds the agent of dextrin granulation.The great burdock achene of having fried is mixed with the granule of making, ultraviolet disinfection, packs and get final product again.

Specific embodiment 3:

Get great burdock achene 3300g and clean, the airing time, at 7-12 hour, parches; The good great burdock achene of airing is put into the pot that completes and go green grass or young crops, the 30-45 minute that completes at 80-100 ℃, then puts into large iron pan and stir-fries, first downwards backward upper, firmly wants evenly, when great burdock achene color starts blackout, starts the moulding in 30-45 minute that stir-fries of little fire; When color becomes pitchy, after taking out, naturally dry; By surplus stock Artemisia anomala 1000g, dried rhizome of rehmannia 1000g, root bark of Chinese wolf-berry 1000g, root of Dahurain angelica 1000g, Poria cocos 1000g, red sage root 1000g, Radix Codonopsis 1000g, eupatorium 1000g, gynostemma pentaphylla 1000g, root bark of white mulberry 1000g, snakegourd 1000g, heart of a lotus seed benevolence 1000g, bighead atractylodes rhizome 1000g, hawthorn 1000g, rhizoma alismatis 1000g, field pennycress 1000g, puts it in 10 times of water gagings and soaks.Drop into multi-function extractor and extract twice, add for the first time 8-10 times of water gaging and decoct 1-2 hour, add for the second time 4-8 times of water gaging and decoct 1-2 hour, merge twice decocting liquid, filter to get filtrate; Heating is concentrated into powder, then puts into baking oven inner drying powdered, and hybrid packed with the good great burdock achene of frying after ultraviolet radiation for sterilizing and disinfecting, during use, direct boiling water is taken after mixing it with water.

Pharmacology toxicity test

Experimental example 1: acute toxicity test of the present invention

One, test material: animal: Kunming mouse, body weight 18-25g, male and female half and half, Shandong University's biology laboratory breeding.Medicine: the present invention's (all raw material mixes decoction 2 times, merges and filters, taking liquid) is containing 0.0365mg/ml.

Two, method:

1, LD50 calculates: adopt improvement karber's method, mouse is divided into 5 groups at random, 10 every group, male and female half and half, dissolve adding distil water of the present invention, are made into Cmax, by the administration of the maximum permission capacity of mouse, institute is followed successively by 18,14.4 to dosage by crude drug amount, 11.5,9.2,7.4 (g.kg-1), in animal fasting (can't help water) after 18 hours, administration at twice in one day (interval half an hour), each 0.5ml, observes animal dead situation.

2, maximum tolerated dose is measured (MTD value): get 20 of mouse, each 10 of male and female.Adding distil water of the present invention is dissolved, be made into maximum concentration, by the maximal tolerance dose of animal, to inject, fill with hello device and can twitch and be as the criterion.In animal fasting (can't help water) after 18 hours, administration at twice (interval half an hour) in a day, each 0.5ml (every ml is containing crude drug 0.36g), total dose is 18g crude drug/kg.d, 300 times of quite clinical adult 50Kg body weight consumption.After administration, Continuous Observation is 7 days.

Three, result of the test:

In LD50 calculates when giving mouse with maximum acceptable concentration and maximum permission capacity (18g/Kg.d), have no dead mouse, do not measure LD50, ask only maximum tolerated dose, in 7 day observation period, its appetite of animal, activity, hair color, the state of mind etc. are all normal, grow normally, there are no death.Select 300 times of doses that are equivalent to clinical dosage, and have no adverse reaction, show that acute toxicity is minimum, MTD > 18g/Kg.d.

Experimental example 2: the result of the test of acute toxicity and long term toxicity

Acute toxicity test: give the present invention by the disposable gavage of small white mouse, maximum concentration 35%, maximum gavage capacity 0.4ml/10g, dosage 14g/kg (every g medicinal powder is equivalent to 10g crude drug), Continuous Observation 7 days, do not find any toxic reaction, because concentration and dosage cannot increase, therefore fail to measure the LD50 of this medicine.Maximum tolerance determination: with maximum concentration, maximum gavage capacity, mice lavage administration 3 times, 5 hours, interval, then Continuous Observation is 7 days, and none example is dead.Medicinal powder dosage is > 42g/kg. day (every g medicinal powder is equivalent to 10g crude drug), by kg body weight, calculate the clinical consumption per day that is equivalent to be grown up 420 times.

Long term toxicity test: whether produce toxic reaction for observing long-term prescription, give respectively rat the present invention and raise clothes, by adult 70 times of clinical consumption per day and 35 times (being 7g/kg/ day and 3.5g/kg/ day), to give and feed 8 weeks continuously, the behavior, feed, the body weight that have no rat occur extremely, with control group ratio, routine blood test, hepatic and renal function, various important organs are all without abnormal change, within the scope of institute's dosage, do not found any toxicity of the present invention.Acute and chronic toxicity test by animal confirms, safe range of the present invention is larger, is a kind of safe and reliable health products.

Pharmacological experiment:

1 experiment material

1.1 medicines and reagent: defaecation ease constipation fat decreasing tea of the present invention, by the method preparation of embodiment 2.Add 10 times of amount distilled water immersion 1h, decoct 1h, filtered through gauze, 3 times repeatedly, finally merge filtrate 3 times, in water-bath, be condensed into the dense thick liquid of 60ml, containing crude drug 1.83g/ml.Control group: fructus cannabis capsule (positive control drug), Hunan Lebang Pharmaceutical Company Limited's product, lot number: 20030802, quantity is 2 tablets/time, every day 2 times, every containing crude drug 3.5g; During tested drug study, by desired concn, be mixed with suspension standby.R-1132, Jiaozuo City universal love pharmaceutcal corporation, Ltd product, lot number: 04051401; India ink, chemical plant product in West Beijing, lot number: 010320.

1.2 animal NIH kind mouse, male and female half and half, body weight 22-25g, by Qingdao, laboratory animal room of traditional Chinese medicine research institute provides, the animal quality certification number: No. 11004th, the moving word of Shandong doctor.A mouse minute sex is raised in air conditioning chamber, 22 ± 2 ℃ of room temperatures, 60 ± 5 ℃ of humidity.Feed standard particle feed, freely drink water and ingest.

2 experimental techniques and result

The defecation test of 2.1 the present invention to normal mouse: get 50 mouse, male and female half and half, are divided into blank group at random by table of random number, and the high, medium and low dosage of the present invention (28.6,14.3,7.15g/kg) group and fructus cannabis capsule (1.8g/kg) group.Blank group gavage gives the suspension containing 2% india ink that distilled water is made into, each administration group suspension containing 2% india ink that gavage gives to be made into liquid respectively, administration volume is 1ml/20g body weight, after administration, mouse is put into little mouse cage, 1, every cage, the clean filter paper of underlay white, Continuous Observation 4h, records time and the ight soil that mouse arranges melena for the first time and counts.The results are shown in Table 1.

Table 1 relaxes bowel relaxing bowel to the impact of normal mouse defecation (x ± s, n=10)

Note: with the comparison of blank group, * P < 0.05, #P < 0.01

The demonstration of table 1 result, high dose group of the present invention can obviously shorten normal mouse and arrange first the melena time, increases 4h row melaena and counts, and more all has significant difference (P < 0.05 or P < 0.01) with blank group; Fructus cannabis capsule group only can increase normal mouse 4h row melaena count (P < 0.05).

The defecation test of 2.2 the present invention to constipation dehydration Constipation Model mouse

Get 60 of mouse, male and female half and half, are divided into blank group at random by table of random number, model control group, the high, medium and low dosage group of the present invention (28.6,14.3,7.15g/kg) and fructus cannabis capsule group (1.8g/kg).Except blank group, all the other are respectively organized mouse taboo water non-fasting 72h and cause constipation dehydration Constipation Model.After modeling, blank group and model group gavage give the 2% india ink suspension that distilled water is made into, each administration group 2% india ink suspension that gavage gives to be made into liquid respectively, administration volume 1ml/20g body weight.After administration, mouse is put into little mouse cage, 1, every cage, the clean filter paper of underlay white, every mouse of observed and recorded is discharged the time (min) of melaena and the melaena sum that the interior mouse of 4h is discharged first.The results are shown in Table 2.

Table 2 impact (x ± s, n=10) of relaxing bowel on constipation dehydration Constipation Model mouse defecation that relax bowel

Note: with the comparison of blank group, * P < 0.01; With model control group comparison, #P < 0.05, & P < 0.01

Table 2 result shows, model control group is arranged the melena time first obviously to be increased compared with blank group, and 4h row melaena is counted and obviously reduced (P < 0.01), represents modeling success.High dose group of the present invention can shorten constipation dehydration Constipation Model mouse and arrange first the melena time, and high, middle dosage group and fructus cannabis capsule group can increase 4h row melaena count (P < 0.05 or P < 0.01).

The defecation test of 2.3 the present invention to compound diphenoxylate (DC) Constipation Model mouse

Get 60 of mouse, male and female half and half, are divided into 6 groups at random by table of random number, i.e. blank group, and model control group, the high, medium and low dosage group of the present invention (28.6,14.3,7.15g/kg) and fructus cannabis capsule group (1.8g/kg).Each is organized mouse fasting and can't help water 12h.Except blank group gavage gives distilled water, all the other are respectively organized gavage and give compound diphenoxylate (DC) suspension 50mg/kg body weight, after 30min, each medication treated animal gavage gives tested medicine, administration volume is 1ml/20g body weight, and blank group and model control group give equivalent distilled water.

In observed and recorded 12h, the argol of every group of mouse discharge is counted.The results are shown in Table 3.

Table 3 result shows, high, the middle dosage group of soup of the present invention and fructus cannabis capsule group all can obviously increase the argol of DC Constipation Model mouse counts, and has compared significant difference (P < 0.05 or P < 0.01) with model control group.

The impact (x ± s, n=10) of table 3 the present invention on compound diphenoxylate (DC) Constipation Model mouse defecation

Group	Dosage (g/kg)	Argol count (x ± s)
			Blank group	?	45.9±15.2
Model control group	?	16.7±8.3*
			High dose group	28.6	29.1±7.4&
Middle dosage group	14.3	26.0±10.3
			Low dose group	7.15	19.6±12.7#
Fructus cannabis capsule group	1.8	27.0±10.2#

Note: with the comparison of blank group, * P < 0.01; With model control group comparison, #P < 0.05, & P < 0.01

The test of 2.4 the present invention to small intestine movement of mice ahead running

Get 50 mouse, male and female half and half, are divided into blank group at random, the high, medium and low dosage group of soup of the present invention and fructus cannabis capsule group.Blank group gavage gives the 2% carbon ink suspension that contains with distilled water configuration, each medication group gavage gives the suspension containing 2% carbon ink that replaces distilled water to be configured to liquid, administration volume is 0.4ml/20g body weight, 30min after gavage, mouse is put to death in cervical vertebra dislocation, the taking-up stomach and intestine of cutting open the belly immediately, be laid on glass plate, measure charcoal end head end displacement and small intestine total length (from pylorus to ileum) in intestinal tube, calculate small intestine ink propulsive rate [distance/small intestine total length * 100% of ink propulsive rate (%)=charcoal end front end and pylorus].The results are shown in Table 4.

Table 4 relaxes bowel relaxing bowel to the impact of small intestine movement of mice ahead running (x ± s, n=10)

Note: with the comparison of blank group, * P < 0.05, #P < 0.01

Result shows, the high, medium and low dosage of the present invention and fructus cannabis capsule all can obviously increase small intestine prepared Chinese ink advance distance and ink propulsive rate (P < 0.05 or P < 0.01), point out the relaxing bowel that relaxes bowel to there is obvious facilitation to small intestine movement of mice ahead running, there is the function that strengthens enterocinesia.

Constipation is the clinical common sympton of a kind of complexity of being caused by different pathological process.Traditional Chinese medicine is thought, though constipation one disease, at large intestine, all has substantial connection with internal organs channels and collaterals, qi-blood-body fluid, spiritual feelings will, is a kind of topical manifestations of yin-Yang, internal organs, qi and blood, disorder of emotion.For old and chronic habitual or the old chronic diseases marked by deficiency of vital energy constipation due to body void after being ill, the deficiency of YIN-blood of many duties, essence and blood loses flourish, and enteron aisle is dry and astringent, logically falls unfavorablely, and waste matter is not all right, causes that just to do matter hard, discharges not smooth.Great burdock achene is clinically for habitual constipation and elderly constipation, there is the relax bowel effect of ease constipation of nourishing yin and nourishing blood, promoting the circulation of qi, this experimental result shows, great burdock achene tea has stronger promotion animal defecation, increases enterocinesia and increases intestinal tube moisture, increase the effect of enteron aisle volume, the relax bowel clinical efficacy of ease constipation of these effects and our nourishing yin and nourishing blood, promoting the circulation of qi is basically identical.The clinical practice that this experiment is the party provides pharmacological basis, for it is further developed foundation is provided.

Specific embodiment: pay certain, female, 33 years old, readme had constipation history, and often a week defecation once, is felt bad extremely.Medicine defaecation ease constipation, does not stop diarrhoea and causes health dehydration, and kidney is impaired, and slight apositia, or else dares to attempt medicine defaecation ease constipation.Mood is gloomy, and complexion is very bad, and face starts to occur chloasma hepaticum butterfly macules, and underbelly swelling sense is obvious, thinks that oneself does not have attraction.Upon somebody's introduction, start to contact Chinese medicine defaecation ease constipation, and need not aviod certain food, to health without any side effect; Attempt a week, side uses: great burdock achene 30g, Artemisia anomala 15g, dried rhizome of rehmannia 13g, root bark of Chinese wolf-berry 12g, root of Dahurain angelica 13g, Poria cocos 11g, red sage root 12g, Radix Codonopsis 12g, eupatorium 12g, gynostemma pentaphylla 12g, root bark of white mulberry 13g, snakegourd 12g, heart of a lotus seed benevolence 12g, bighead atractylodes rhizome 12g, hawthorn 13g, rhizoma alismatis 12g, field pennycress 12g, makes tea-drinking, and wrap every days two, second day just starts defaecation ease constipation, thinks that belly feels bad, and gets rid of a lot of stools, feels brisk a lot.Because not dieting completely.Coordinate great burdock achene defaecation bowel tea, adhere to every day moving 1 hour, find that stool starts normal, believe the effect of great burdock achene defaecation bowel tea; Adhere to using one month, find that the potbelly of oneself starts to flatten, thin 15 jin, and there is no apocleisis completely, dehydration, diarrhoea phenomenon.Recovered stature, and not specially fasting.Feel good.There is no stool, there is no abdomen.

Claims (10)

1. a great burdock achene defaecation health care tea for moistening intestines, it is characterized in that, in described great burdock achene defaecation health care tea for moistening intestines, the parts by weight of various raw materials comprise: 20～50 parts of great burdock achenes, 10～20 parts of Artemisia anomalas, 10～20 parts, the dried rhizome of rehmannia, 10～20 parts of the root barks of Chinese wolf-berry, 10～20 parts of the roots of Dahurain angelica, 10～20 parts, Poria cocos, 10～20 parts of the reds sage root, 10～20 parts of Radix Codonopsis, 10～20 parts of eupatoriums, 10～20 parts of gynostemma pentaphylla, 10～20 parts of the root barks of white mulberry, 10～20 parts of snakegourds, 10～20 parts of heart of a lotus seed benevolence, 10～20 parts of the bighead atractylodes rhizomes, 10～20 parts of hawthorn, 10～20 parts of rhizoma alismatis, 10～20 parts of field pennycress.

2. great burdock achene defaecation health care tea for moistening intestines according to claim 1, it is characterized in that, in described great burdock achene defaecation health care tea for moistening intestines, the parts by weight of various raw materials are: 20～30 parts of great burdock achenes, 10～15 parts of Artemisia anomalas, 10～15 parts, the dried rhizome of rehmannia, 10～15 parts of the root barks of Chinese wolf-berry, 10～15 parts of the roots of Dahurain angelica, 10～15 parts, Poria cocos, 10～15 parts of the reds sage root, 10～20 parts of Radix Codonopsis, 10～20 parts of eupatoriums, 10～20 parts of gynostemma pentaphylla, 10～20 parts of the root barks of white mulberry, 10～20 parts of snakegourds, 10～20 parts of heart of a lotus seed benevolence, 10～20 parts of the bighead atractylodes rhizomes, 10～20 parts of hawthorn, 10～20 parts of rhizoma alismatis, 10～20 parts of field pennycress.

3. great burdock achene defaecation health care tea for moistening intestines according to claim 1, it is characterized in that, the ratio of weight and number of various raw materials in described great burdock achene defaecation health care tea for moistening intestines: 20～40 parts of great burdock achenes, 10～20 parts of Artemisia anomalas, 10～20 parts, the dried rhizome of rehmannia, 10～20 parts of the root barks of Chinese wolf-berry, 10～20 parts of the roots of Dahurain angelica, 10～20 parts, Poria cocos, 10～20 parts of the reds sage root, 10～15 parts of Radix Codonopsis, 10～15 parts of eupatoriums, 10～15 parts of gynostemma pentaphylla, 10～15 parts of the root barks of white mulberry, 10～15 parts of snakegourds, 10～15 parts of heart of a lotus seed benevolence, 10～15 parts of the bighead atractylodes rhizomes, 10～15 parts of hawthorn, 10～15 parts of rhizoma alismatis, 10～15 parts of field pennycress.

4. a preparation method for great burdock achene defaecation health care tea for moistening intestines as described in claim 1～3 any one, is characterized in that, the preparation process of described great burdock achene defaecation health care tea for moistening intestines comprises following aspect:

A. the preparation of great burdock achene;

B. by described other raw material pulverizing, immersion, heating, refluxing extraction 2 times;

C. the liquid again surplus stock being extracted is condensed into granule, pulvis or paste;

D. concentrated granule, pulvis or paste are mixed with the great burdock achene preparing, be prepared into health care medicinal tea.

5. the preparation method of great burdock achene defaecation health care tea for moistening intestines according to claim 4, is characterized in that, in described step a, gets the great burdock achene obtaining and cleans, and the airing time, at 7-12 hour, parches; The good great burdock achene of airing is put into the pot that completes and go green grass or young crops, the 30-45 minute that completes at 80-100 ℃, then puts into large iron pan and stir-fries, first downwards backward upper, firmly wants evenly, when great burdock achene color starts blackout, starts the moulding in 30-45 minute that stir-fries of little fire; When color becomes pitchy, after taking out, naturally dry.

6. the preparation method of great burdock achene defaecation health care tea for moistening intestines according to claim 4, is characterized in that, in described step b, surplus stock is cleaned to impurity elimination, dries, and is ground into particle, soaks 1 hour; Soaked raw material is put to boiling secondary in multi-function extractor; Add up for the first time the water of 10 times of amounts of medicinal material, decoct 1.5～2 hours, get decocting liquid, filter; The water that adds for the second time 7 times of amounts of total amount, decocts 1～1.2 hour, gets twice decocting liquid and mixes, and filters.

7. the preparation method of great burdock achene defaecation health care tea for moistening intestines according to claim 4, it is characterized in that, in described step c, the filtrate of filtration is inserted in economic benefits and social benefits vacuum concentrator, the concentrate that while being concentrated into 90 ℃, relative density is 1.05, set to 0～5 ℃ of deepfreezes 24 hours; Refrigeration liquid is added to 0.3% filter aid diatomite, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 1g crude drug amount, then adds dextrin and puts into granulator and granulate.

8. treat according to claim 4 the preparation method of great burdock achene defaecation health care tea for moistening intestines, it is characterized in that, in described steps d, the particle that the good great burdock achene of frying is prepared with surplus stock mixes, and ultraviolet disinfection, packs and get final product.

9. the preparation method of basis great burdock achene defaecation health care tea for moistening intestines as described in claim 1～3 any one, it is characterized in that, when other raw materials of described great burdock achene defaecation ease constipation Antilipemic health tea are made pulvis, step is: other raw materials are put into 10 times of amount ethanol, heating and refluxing extraction 2 times, each 1～2 hour, No. 2 extracts are merged standing; The dregs of a decoction of the component raw medicinal material of more above-mentioned alcohol extract being crossed add 10 times of water gaging heating and refluxing extraction 2 times, each 1～2 hour, No. 2 extracts are merged standing; Above-mentioned two kinds of extracts are merged, and reclaiming after ethanol decompression, to put into inspissator concentrated, then puts into drying baker and be dried into powder, after ultraviolet radiation for sterilizing and disinfecting, merges packing with the good great burdock achene of frying.

10. the preparation method of great burdock achene defaecation health care tea for moistening intestines according to claim 9, it is characterized in that: in above-mentioned concentration step, two kinds of extracts are merged, after recovery ethanol, reducing pressure, it is concentrated to put into inspissator, the concentrate that while being concentrated into 90 ℃, relative density is 1.05, set to 0～5 ℃ of deepfreezes 24 hours; Refrigeration liquid is added to 0.3% filter aid diatomite, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 1g crude drug amount.