CN104304602A - Pagoda tree fruit tea capable of softening blood vessels and preparation method thereof - Google Patents

Pagoda tree fruit tea capable of softening blood vessels and preparation method thereof Download PDF

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CN104304602A
CN104304602A CN201410681588.1A CN201410681588A CN104304602A CN 104304602 A CN104304602 A CN 104304602A CN 201410681588 A CN201410681588 A CN 201410681588A CN 104304602 A CN104304602 A CN 104304602A
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parts
fructus sophorae
blood
tea
blood vessel
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不公告发明人
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Qingdao Hengbo Instrument Co Ltd
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Qingdao Hengbo Instrument Co Ltd
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Abstract

The invention provides a pagoda tree fruit tea capable of softening blood vessels. The pagoda tree fruit tea comprises, by weight, 10-50 parts of pagoda tree fruits, 10-20 parts of hawthorn leaves, 10-20 parts of gynostemma pentaphyllum, 10-20 parts of dried radix rehmanniae, 10-20 parts of salviae miltiorrhizae, 10-20 parts of eucommia ulmoides leaves, 10-20 parts of angelica sinensis, 10-20 parts of cornus officinalis, 10-20 parts of poria cocos, 10-20 parts of atractylodes macrocephala koidz, 10-20 parts of ligusticum wallichii, 10-20 parts of white mulberry root-bark, 10-20 parts of radix scutellariae, 10-20 parts of dried orange peel and 10-20 parts of himalayan teasel roots. Traditional Chinese medicine can soften the blood vessels and prevent cardiovascular and cerebrovascular diseases, and has the advantages of being non-toxic and capable of completely absorbed by living bodies. The healthy tea has good medical value and can reduce blood pressure and blood fat, promote blood circulation to remove blood stasis, soften the blood vessels, reduce cholesterol, expel wind and heat, moisten large intestines, cool the blood and relax the bowels after being drunk for a long time; moreover, the pagoda tree fruit tea is good for people who have the symptoms of depression, hot eyes and tearing and feel dizzy to fall down; the pagoda tree fruit tea can make blood components purified and can also improve microcirculation.

Description

Fructus Sophorae tea of a kind of softening blood vessel and preparation method thereof
Technical field
The present invention relates to the health protection tea containing deriving from plant composition, particularly a kind of Fructus Sophorae tea and preparation method thereof of softening blood vessel.
Background technology
The high speed development of Modern Urban Living, also brings a series of rich man's disease.Wherein " three is high " and obesity are the primary enemies of puzzlement people." three high diseases " refers to hypertension, hyperglycaemia (diabetes) and hyperlipemia.Usually along with obesity.They be modern society derive from " rich man's disease ", possible individualism, also may be interrelated.As: diabetes patient is easy to suffer from hypertension or hyperlipemia simultaneously, and high fat of blood is the principal element of artery sclerosis formation and development, and arteriosclerotic's blood vessel elasticity difference aggravation blood pressure raises, so the later stage all defines " three high diseases ".
Young occur " disease of old people " increases year by year in recent years.Arteriosclerotic cardiovascular and cerebrovascular diseases occur gradually, many and bad life style, the accumulation environmental pollution of vivotoxin causes blood viscousness cohesion relevant, life, work strain, smoking, excessive drinking, overnutrition, blood thickness, abnormal composition (toxin) etc. in blood, severe overweight, form artery sclerosis, the DVT at vascular inflammation and initial stage, mid-term, the dysemia phase, teenager is cradle even, mid-term, angiosis becomes the hemodynamic change phase, the young and the middle aged can occur, late period, SE (a sick phase) angiemphraxis of visceral organ injury phase or life is serious, cardiovascular and cerebrovascular diseases are caused more than 50%, peripheral vessels occurs, form serious hypertension, the exhaustion of severe patient life.
Day by day flourishing due to economy, the continuous lifting of modern's living standard, cause people too much have deep love for enjoy, do not notice that the life style of oneself, behavioural habits, diet are had a liking for, thus the disease caused.Society with fast rhythm lives, the operating pressure of keen competition, serious threat is caused to the physical and mental health of modern, add that long-term diet is unreasonable, that is: smart grain replaces coarse food grain completely, the agricultural chemicals remained in the absorption of a large amount of three height (high heat, high protein, higher fatty acid), more than three (anticorrisive agent is many, flavoring agent is many, hormone many) food and food, chemical fertilizer stockpiling in vivo, add air, pollution of waterhead and amount of exercise less than normal, obesity and diabetes have just become the rich man's disease of city gang.
Be what has statistics about three height, in the Chinese ten large causes of death, the death rate relevant to metabolic disease is just up to 35.7%, and the death toll relevant to " three is high " also accounts for 27% of total death toll.High fat of blood can cause blood vessel embolism; Hypertension can cause cerebral hemorrhage and rupture of blood vessel in brain; Hyperglycaemia can cause diabetes.The World Health Organization once clearly proposed, and prevented the first line of defence of cardiovascular disease from reducing " three is high " exactly and controlling " three is high ".A lot of diabetes patient is with hyperlipidemia, and therefore diabetes and hyperlipidemia, people call that sister is sick usually, and think that high fat of blood is the secondary disease of diabetes.The diabetic of about 40% has disorders of lipid metabolism according to statistics.Be characterized in that triglycerides increases to reduce with HDL.
Cardiovascular disease is a kind of disease that the modern incidence of disease is very high.If just prevention cardiovascular and cerebrovascular disease is so just simple a bit can have some deep sea fish oil capsule and pill and lecithin capsule and pill for a long time, and both cooperations are eaten better together, can softening blood vessel.But a lot of people does not like eating, and thinks dangerous, containing hormone.Market has the traditional Chinese medicine health care product of many softening blood vessels, but really can the traditional Chinese medicine health care product of softening blood vessel little, the health products of all softening blood vessels on market are possible delay vascular sclerosis at most.Moreover even if you have found, also may not suit the medicine to the illness, the problem for the treatment of cardiac and cerebral vascular diseases still will be considered carefully relatively good.Softening blood vessel method is a lot, has dietetic treatment, kinesiatrics, medicinal treatment and clinical treatment etc.These methods more or less have weak point, and what have also easily causes side effect, as diarrhoea, apocleisis etc., especially very improper to the elderly.And health treatment has easy to use, have no side effect, the features such as effect is remarkable, and extremely consumers.
The fruit that Chinese scholartree is tied, popular name among the people connects beans Chinese scholartree.Chinese scholartree, summer-flowering, October fruit maturation.Pulp is yellowish light green, interior parcel black seed; Fruit is Kidney bean angular shape, has many particles that also has of individual particle to connect together, is therefore named and makes Chinese scholartree connect beans.Chinese scholartree connects beans and hangs prolongedly in the tree not fall, winter, and through frost, Exposure to Sunlight, wind, after drying, can pick, and through processing, makes Fructus Sophorae tea, drinks for people.
Fructus Sophorae tea has good medical value, drinks for a long time and can control hemorrhoid by reducing blood pressure and blood fat gut purge fire, also has softening blood vessel, norcholesterol, dispelling wind heat, profit large intestine, effect of cool blood defaecation.Ambition is unhappy, and hot eyes is shed tears, and dizzy for falling person, normal this tea of drink is quite helpful.Since permanent, North China is once being with self-control among the people richly endowed by nature from drink.
Carry according to " herbal classic ", in Fructus Sophorae master five, perverse trend heat, only saliva and spittle, mend and hinder absolutely, five hemorrhoid, fiery sore, and married woman's breast lump in the abdomen, son hides shoot.Supplement to the Herbal carries its desinsection and removes wind, and improving eyesight is except hot tears, and between brains ambition, hot blast is unhappy, and wind is dizzy for falling, and ptysis is as liquor-saturated in mind, ripples as person on ship car." the southern regions of the Yunnan Province book on Chinese herbal medicine " carries its styptic powder subcutaneous ulcer.Control five hemorrhoid discharging fresh blood stools, red white heat rushes down dysentery." about can cure mirror " carry its clear away heart-fire, lung, spleen, liver, large intestine fire.Control trusted subordinate's heat pain." book on Chinese herbal medicine asks former " is carried its Fructus Sophorae profit liver and is nourished blood.Control infantile malnutrition due to digestive disturbances or intestinalparasites, malignant boil, bloody flux, collapse blood; Nucleon in its angle, mends brain, desinsection.
The Fructus Sophorae itself is slightly poisonous, without the process of preparing Chinese medicine directly drink be easy to cause poisoning.Our technique is nine steaming nine solarizations, its toxicity is dispelled completely, can make the relieved use of consumer.Be rich in fiber inside the Fructus Sophorae, fiber can promote intestinal peristalsis, helps defecation, reduces body inner cholesterol, and minimizing toxin, refuse accumulate in vivo, reaches prevention of stroke and the effect of preventing and treating cancer of the stomach, the cancer of the uterus.Often the edible Fructus Sophorae stimulates circulation, so be applicable to very much the working clan of long-term sitting office, remove stomach rubbish, prevent human body from crossing presenility, moist skin, preventing apoplexy and hypertension, detoxicating intestine, reduction cholesterol and blood sugar, and applicable diabetic eats for a long time.
Decoction is the conventional dosage forms of the traditional Chinese medical science, and it is convenient with advantages such as disease plus-minuss to have, but decoction decocting, carries, uses inconvenience, and composition is not exclusively fried, and mouthfeel is poor, is not suitable for the Modern human populations medication custom.The various health products sold on the market now, dragons and fishes jumbled together for medicine, great majority are the amusement of false propaganda, what have does not only have health-care components, also cause the huge injury of the person, therefore, search of health effective softening blood vessel method has very real significance, softening blood vessel active material safely and effectively, reduce the incidence of disease of cardiovascular and cerebrovascular disease, be the key that people expect to deal with problems always.Chinese medicine softening blood vessel, having advantage that is nontoxic, that can be absorbed completely by organism, is the Main way that we study.There are softening blood vessel, promoting blood circulation and removing blood stasis, hypoglycemic, antioxidation in present market in the urgent need to developing one, and energy interference body is to the absorption of fat, promotes the product that the rubbish taken in excretes, and has advantage that is nontoxic, that can be absorbed completely by organism.
Summary of the invention
Technical problem to be solved by this invention is, decoction is the conventional dosage forms of the traditional Chinese medical science, and it is convenient with advantages such as disease plus-minuss to have, but decoction decocting, carries, uses inconvenience, and composition is not exclusively fried, and mouthfeel is poor, is not suitable for the Modern human populations medication custom.The various health products sold on the market now, dragons and fishes jumbled together for medicine, great majority are the amusement of false propaganda, what have does not only have health-care components, also cause the huge injury of the person, therefore, the effective softening blood vessel of search of health, health products that are promoting blood circulation and removing blood stasis, toxin expelling have very real significance.Health protection tea of the present invention has good medical value, and drinking for a long time can softening blood vessel, norcholesterol, dispelling wind heat, profit large intestine, effect of cool blood defaecation.Very strong health-care effect is had to the incidence of disease reducing cardiovascular and cerebrovascular.
For solving above-mentioned technical barrier, the invention provides a kind of Fructus Sophorae tea of softening blood vessel, the parts by weight of the various raw materials of Fructus Sophorae tea described in it can be: the Fructus Sophorae 10 ~ 50 parts, leaves of Hawthorn 10 ~ 20 parts, gynostemma pentaphylla 10 ~ 20 parts, 10 ~ 20 parts, the dried rhizome of rehmannia, the red sage root 10 ~ 20 parts, folium cortex eucommiae 10 ~ 20 parts, Radix Angelicae Sinensis 10 ~ 20 parts, Fructus Corni 10 ~ 20 parts, 10 ~ 20 parts, Poria cocos, the bighead atractylodes rhizome 10 ~ 20 parts, Ligusticum wallichii 10 ~ 20 parts, the root bark of white mulberry 10 ~ 20 parts, the root of large-flowered skullcap 10 ~ 20 parts, dried orange peel 10 ~ 20 parts, interrupted 10 ~ 20 parts.
The Fructus Sophorae tea of described softening blood vessel, the parts by weight of the various raw materials of Fructus Sophorae tea described in it can also be: the Fructus Sophorae 10 ~ 30 parts, leaves of Hawthorn 10 ~ 15 parts, gynostemma pentaphylla 10 ~ 15 parts, 10 ~ 15 parts, the dried rhizome of rehmannia, the red sage root 10 ~ 15 parts, folium cortex eucommiae 10 ~ 15 parts, Radix Angelicae Sinensis 10 ~ 15 parts, Fructus Corni 10 ~ 15 parts, 10 ~ 20 parts, Poria cocos, the bighead atractylodes rhizome 10 ~ 20 parts, Ligusticum wallichii 10 ~ 20 parts, the root bark of white mulberry 10 ~ 20 parts, the root of large-flowered skullcap 10 ~ 20 parts, dried orange peel 10 ~ 20 parts, interrupted 10 ~ 20 parts.
The Fructus Sophorae tea of described softening blood vessel, the parts by weight of the various raw materials of Fructus Sophorae tea described in it also can be: the Fructus Sophorae 10 ~ 40 parts, leaves of Hawthorn 10 ~ 20 parts, gynostemma pentaphylla 10 ~ 20 parts, 10 ~ 20 parts, the dried rhizome of rehmannia, the red sage root 10 ~ 20 parts, folium cortex eucommiae 10 ~ 20 parts, Radix Angelicae Sinensis 10 ~ 20 parts, Fructus Corni 10 ~ 20 parts, 10 ~ 15 parts, Poria cocos, the bighead atractylodes rhizome 10 ~ 15 parts, Ligusticum wallichii 10 ~ 15 parts, the root bark of white mulberry 10 ~ 15 parts, the root of large-flowered skullcap 10 ~ 15 parts, dried orange peel 10 ~ 15 parts, interrupted 10 ~ 15 parts.
For solving the problems of the technologies described above, the present invention also provides a kind of preparation method of Fructus Sophorae tea of softening blood vessel, and described in it, the preparation process of Fructus Sophorae tea comprises following aspect:
A. the preparation of the Fructus Sophorae;
B. the preparation of leaves of Hawthorn, folium cortex eucommiae;
C. by other raw material soaking ethanol described, extract 2 times;
D. again the concentration of liquid medicine that surplus stock extracts is become granule, pulvis or paste;
E. concentrated granule, pulvis or paste are mixed with the Fructus Sophorae prepared, be prepared into health protection tea.
In described step a, after can the dry Fructus Sophorae being adopted down from Chinese scholar tree midwinter, clear water is cleaned, and dries, and removing impurity and dust, be placed on food steamer, add burning hot steaming again; Steamed, dry; Such Continuous Heat steams nine times, airing nine times; When the Fructus Sophorae becomes aterrimus, after treating its drying, get honey and put into pot heating, pour in pot by the Fructus Sophorae shone after honey melts, stirring loads container after cooling and dries in the shade, and sealing saves backup.
In described step b, the leaves of Hawthorn of results, folium cortex eucommiae can be cleaned and be cut into filament, airing, parch; Leaves of Hawthorn good for airing, folium cortex eucommiae are put into the pot that completes and gone green grass or young crops, and complete 30-45 minute at 70-100 DEG C, then puts into large iron pan and stir-fry, on first backward downwards, firmly want evenly, when leaves of Hawthorn, folium cortex eucommiae color start jaundice, start little fire stir-fry 20-30 minute shaping; Naturally dry after taking out.
In described step c, surplus stock can be cleaned impurity elimination, dry, be ground into particle, add in the ethanol of 5-10 times amount and soak 1-2 hour, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extract, 100-120 order filters, then is the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, when ultrafiltrate reduced pressure concentration relative density is 80 DEG C 1.36 pasty state, stand for standby use.
In described steps d, the concentrate of said extracted can be inserted in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C, relative density is the concentrate of 1.05, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Will refrigeration liquid add 0.3% filter aid diatomite, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 1g crude drug amount, convection drying powdered, or adds dextrin and be in harmonious proportion and make particle.
For solving the problems of the technologies described above, the present invention reoffers a kind of preparation method of Fructus Sophorae tea of softening blood vessel, and when paste made by other raw materials of described Fructus Sophorae tea, step can be:
A, get other raw materials and put into ethanol and soak, heat is extracted 2 times, and becoming paste, is component 1;
B, dregs of a decoction extracting in water 2 times, thickening filtration is paste, is component 2;
C, by also 2-in-1 to component 1 and component, be condensed into medicinal extract, after ultraviolet radiation for sterilizing and disinfecting with prepare the Fructus Sophorae and merge and pack.
In described step a, raw material can be got add in the ethanol of 5-10 times amount and soak 1-2 hour, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extract, 100-120 order filters, then is the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, when ultrafiltrate reduced pressure concentration relative density is 80 DEG C 1.36 medicinal extract, heating is concentrated into paste, stand for standby use, becomes component 1; In described step b, the dregs of a decoction that alcohol extract is crossed can be put into 10 times of water gagings, then put into extractor heating and boil 1 hour, filter, filtrate is for subsequent use; Filter residue adds water, and second time heating, boils 45 minutes, and filter, filtrate is for subsequent use; 2 filtrates be combined, by filtered through gauze, add 50-60% ethanol in residue, 60 DEG C-70 DEG C are continued lixiviate 2h, and every 10min stirs once, filtered through gauze, merge leaching liquor, are condensed into pasty state, become component 2; Above-mentioned two kinds of extracts can be merged by described step c, decompression recycling ethanol to be concentrated into liquor strength be 0.6g crude drug/mL, after suction filtration, when the relative density of filtrate is about 20 DEG C 1.08; Be decompressed to 0.03-0.08MPa, temperature remains on 60-80 DEG C, and being concentrated into relative density is 1.20, the medicinal extract of temperature to 60 DEG C-70 DEG C.
The technique effect that the present invention is useful is, health protection tea of the present invention has good medical value, and drinking for a long time can softening blood vessel, norcholesterol, dispelling wind heat, profit large intestine, effect of cool blood defaecation.Very strong health-care effect is had to the incidence of disease reducing cardiovascular and cerebrovascular.Cardiovascular disease belongs to multifactor relevant chronic disease, and the course of disease is longer, needs long-term prescription just can reach good effect, thus should select to take, carry, health protection tea formula drink easy to use more can improve health-care effect.Health protection tea of the present invention has good medical value, and drinking for a long time can reducing blood pressure and blood fat, and gut purge fire, controls hemorrhoid, also has softening blood vessel, norcholesterol, dispelling wind heat, profit large intestine, effect of cool blood defaecation.Unhappy to ambition, hot eyes is shed tears, and dizzy for falling person, normal this tea of drink is also quite helpful.
Detailed description of the invention
Cardiovascular disease is a kind of disease that the modern incidence of disease is very high.If just prevention cardiovascular and cerebrovascular disease is so just simple a bit can have some deep sea fish oil capsule and pill and lecithin capsule and pill for a long time, and both cooperations are eaten better together, can softening blood vessel.But a lot of people does not like eating, and thinks dangerous, containing hormone.Market has the traditional Chinese medicine health care product of many softening blood vessels, but really can the traditional Chinese medicine health care product of softening blood vessel little, the health products of all softening blood vessels on market are possible delay vascular sclerosis at most.Moreover even if you have found, also may not suit the medicine to the illness, the problem for the treatment of cardiac and cerebral vascular diseases still will be considered carefully relatively good.Softening blood vessel method is a lot, has dietetic treatment, kinesiatrics, medicinal treatment and clinical treatment etc.These methods more or less have weak point, and what have also easily causes side effect, as diarrhoea, apocleisis etc., especially very improper to the elderly.And health treatment has easy to use, have no side effect, the features such as effect is remarkable, and extremely consumers.
Arteriosclerotic cardiovascular and cerebrovascular diseases occur gradually, many and bad life style, the accumulation environmental pollution of vivotoxin causes blood viscousness cohesion relevant, life, work strain, smoking, excessive drinking, overnutrition, blood thickness, abnormal composition (toxin) etc. in blood, severe overweight, form artery sclerosis, the DVT at vascular inflammation and initial stage, mid-term, the dysemia phase, teenager is cradle even, mid-term, angiosis becomes the interim youth of hemodynamic change and can occur, late period, SE (a sick phase) angiemphraxis of visceral organ injury phase or life is serious, cardiovascular and cerebrovascular diseases are caused more than 50%, peripheral vessels occurs, form serious hypertension, the exhaustion of severe patient life, young occur " disease of old people " increases year by year in recent years.
In the Chinese ten large causes of death, the death rate relevant to metabolic disease is just up to 35.7%, and the death toll relevant to " three is high " also accounts for 27% of total death toll.High fat of blood can cause blood vessel embolism; Hypertension can cause cerebral hemorrhage and rupture of blood vessel in brain; Hyperglycaemia can cause diabetes.The World Health Organization once clearly proposed, and prevented the first line of defence of cardiovascular disease from reducing " three is high " exactly and controlling " three is high ".A lot of diabetes patient is with hyperlipidemia, and therefore diabetes and hyperlipidemia, people call that sister is sick usually, and think that high fat of blood is the secondary disease of diabetes.The diabetic of about 40% has disorders of lipid metabolism according to statistics.Be characterized in that triglycerides increases to reduce with HDL.When the reason that diabetes cause blood fat to increase is due to diabetes patient's insufficient insulin, body lactonase activity lowers, and therefore easily blood fat increases.Diabetes itself also accompany fat, protein and water, dielectric disorder except carbohydrate metabolism disturbance simultaneously on the other hand.Often there is free fatty to mobilize out from fat depot, triglycerides and FFA concentrations in blood are increased.Diabetes B people takes food too much on the one hand again, and motion is few, and impel lipid synthesis in body to increase, this is also the reason causing blood fat to increase.And fat companion's high fat of blood person, because insulin receptor number reduces relatively, thus produce insulin resistance, easy induced Diabetic.Blood fat increased perosn also easily causes the heart, cerebrovascular complication.
The Fructus Sophorae is dry flower and alabastrum, the ripening fruits of legume Chinese scholartree.For Pharmacopoeia of the People's Republic of China nineteen ninety version is recorded.Flower is claimed sophora flower by medicinal material commodity, and bud claims the sophora bud, and fruit claims the Fructus Sophorae.Fructus Sophorae bitter, cold in nature.Return liver, large intestine channel.There are clearing heat-fire, blood cooling and hemostatic functions.Have blood in stool for intestines heat, hemorrhoid swell hemorrhage, the headache of liver heat, dizzy hot eyes.
There is long history in China to the application of Chinese scholartree and cultivation.Explaining the meaning of the word the earliest just to describe in monograph " elegant " has: " Chinese scholartree has several, leaf large and black person's name rafter Chinese scholartree, closes the person's of opening name house lizard at night Chinese scholartree daytime, the thin and dark green person of leaf but the Chinese scholartree of meaning, and its function is not sayed different ... modern doctor is maximum with Chinese scholartree person ".
Be loaded in Eastern Han Dynasty's Shennong's Herbal as medicinal head, be classified as top grade, fruit claims Chinese scholartree real, i.e. the modern Fructus Sophorae.Later history tree is all on the books, beam Tao Hongjing cloud: " Chinese scholartree is to be connected many persons as well "; Northern and Southern Dynasties' thundercloud: " Chinese scholartree is real, after Fan Cai get, removes list and five sub-persons, only gets two, three sub-persons.... allly to make, break with the order of "painted-face" character in opera mallet, with black cow's milk leaching one night, steamed use "; Song's " figure is through book on Chinese herbal medicine " is carried: " Chinese scholartree is grown directly from seeds Henan Ping Ze, and the present has it everywhere.Its wood has high large person ... "; " dietetic materia medica " also carries: " the real main perverse trend of Chinese scholartree produces difficult wound absolutely.At the beginning of spring, tender leaf is also edible, main urticaria, all wind pains of tooth ".Sophora flower is first appeared in " Japan hanako materia medica " (i.e. " large bright book on Chinese herbal medicine ").Thereafter medicine book all records the successive dynasties.Bright " Bencao Pinhui Jingyao " note has: " person of not opening is good for flower " ... ancient times uses position all to refer to bud.
The Fructus Sophorae is upper cage steaming after cleaning, and steam and once shine once, steaming 9 times, shines 9 times altogether.Then put into pot by proper honey to heat, after honey melts, the Fructus Sophorae shone is poured in pot, stir after cooling and load container.
Fructus Sophorae tea glycol is good to eat, long times of aftertaste, and this tea has softening blood vessel, hypotensive, norcholesterol, dispelling wind heat, profit large intestine, effect of cool blood defaecation.Ambition is unhappy, and hot eyes is shed tears, and dizzy for falling, it is quite helpful that hemorrhoid hemorrhage person often drinks this tea.Especially to falling three fat, prevention and therapy hemorrhoid have fabulous curative effect.Heat-clearing, profit liver, cool blood, hemostasis.Control intestines diarrhea due to wind-evil blood, hemorrhoid blood, uterine bleeding, blood drenches, bloody flux, and ambition is unhappy, and wind is dizzy for falling, and the erosion of vulva is wet itches.Clear away heart-fire, lung, spleen, liver, large intestine fire.Control trusted subordinate's heat pain.Profit liver is nourished blood.Control infantile malnutrition due to digestive disturbances or intestinalparasites, malignant boil, bloody flux, collapse blood; Nucleon in its angle, mends brain, desinsection.
The red sage root is bitter, is slightly cold.The thoughts of returning home, Liver Channel.Stasis-dispelling and pain-killing, activating blood to promote menstruation, clear away heart-fire relieving restlessness.For irregular menstruation, through closing dysmenorrhoea, a lump in the abdomen causing distension and pain, and chest ventral spine pain, hot numbness pain, sore swells and ache, dysphoria and insomnia.For sternal rib hypochondriac pain, arthralgia due to wind-dampness, abdominal mass lumps, and sore swells and ache, fall fall forward grieved, irregular menstruation, through closing dysmenorrhoea, postpartum stasis of blood pain etc.Treatment sternal rib pain, abdominal mass caking, and irregular menstruation, through amenorrhoea pain, there is good effect." detailed outline " carries: the red sage root, and by " the sensible opinion of married woman " cloud, gynecopathy controlled by Siwu Tang, pays no attention to antenatal postpartum, how many through water, all can be general, and the only taste red sage root falls apart, and cures mainly identical with it.The lid red sage root can break place blood, mends new blood, peaceful tire, and fall stillborn foetus, only metrorrhagia stagnant under, menstruation regulating arteries and veins.Main Compositions of Radix Salviae Miltiorrhizae tanshinone has hemangiectasis, improves circulation, removes the effects such as intravascular coagulation, has effect of invigorating blood circulation trace, and can promote that liver blood circulates, be beneficial to liver cell regeneration.
Bighead atractylodes rhizome bitter, sweet, temperature.Return spleen, stomach warp.Cure mainly strengthening the spleen and replenishing qi, eliminating dampness Li Shui, hidroschesis, antiabortive.Few for insufficiency of the spleen food, abdominal distension is had loose bowels, and phlegm and retained fluid is dizzy throbs with fear, oedema, spontaneous perspiration, fetal irritability.The bighead atractylodes rhizome has CDCC to oncocyte, can reduce the rate of increase of oncocyte, lowers the aggressive of tumor tissue, improves the ability of the antitumor reaction of body.Baizhu volatile oil has inhibitory action to mouse EC, lymphosarcoma ascitic type, the cancer of the esophagus (Ecal09), sarcoma 180 etc.Atractylodes lactone B lumbar injection is to the murine sarcoma people.Also remarkable inhibitory action is had." property of medicine opinion " carries it: monarch, taste is sweet, pungent, nontoxic.Energy main large wandering arthritis, for many years diarrhea due to disorder of qi, trusted subordinate's distending pain, the broken place food that disappears, appetizing, removes sputum, except fever and chills, lets out under stopping.Interarea light is pleased, and preserves youthful looks, de-black.Swelling of harnessing the river is full, tells to vomit inverse, and crymodynia in abdomen, vomits and diarrhoea incessantly, and the cold dysentery of stomach Qi deficiency.
The root bark of white mulberry is the root skin of moraceae plants mulberry Morus alba L..Main product in Anhui, Henan, Zhejiang, Jiangsu, the ground such as Hunan.Effect: removing heat from lung and relieving asthma, inducing diuresis for removing edema.Cough for lung heat and breathe heavily, the edema of the face, the diseases such as difficult urination." property of medicine opinion ": make, flat.Can control lung qi breathes heavily full, aqueous vapor edema, and main wound is exhausted, dredging water passages, and disappear aqueous vapor, the headache of consumptive disease visitor heat, interior tonifying for the deficiency." Japan hanako materia medica ": temperature, in tune, lower gas.Dissolving phlegm is quenched the thirst, sharp intestine and small intestine, appetizing, lower food, and kill abdomen and hide worm, only cholera is vomited and diarrhoea.
Poria cocos taste is sweet, light, property is put down, and is used as medicine and has the function of clearing damp and promoting diuresis, beneficial spleen and stomach, antitoxic heart-soothing and sedative.Modern medicine study: Poria cocos energy enhanced machine body immunity function, pachymaran has significantly antitumor and protect the liver dirty effect.Poria cocos slightly sweet flavor is put down, and enters the heart, lung, the spleen channel.There is eliminating dampness and diuresis, strengthening the spleen and stomach, effect of antitoxic heart-soothing and sedative.Can control difficult urination, oedema turgor, phlegm and retained fluid is coughed inverse, vomits inverse, and vomiting during early pregnancy, has loose bowels, seminal emission, stranguria with turbid discharge, palpitation with fear, forgetful disease such as grade.The Li Shui of Poria cocos, is reached by strong fortune spleen PFT, different from the Chinese medicine of other direct Li Shui.For splenasthenic diarrhea, the lower Poria cocos of band can invigorating the spleen, again can excreting dampness, and for having loose bowels caused by insufficiency of the spleen dysfunction of the spleen in transportation and transformation, being with down, application Poria cocos has the effect of giving consideration to both the incidental and fundamental, the compatibilities such as normal and Radix Codonopsis, the bighead atractylodes rhizome, Chinese yam.Can be used as tonifying lung spleen, control the adjuvant of the deficiency of vital energy.
The dried rhizome of rehmannia: the dried rhizome of rehmannia is also radix rehmanniae recen, the fresh or dry block root of Scrophulariaceae herbaceos perennial glutinous rehmannia Rehmannia glutinosa Libosch..Heat-clearing, promote the production of body fluid, moisturize, laxation, the broken stasis of blood, raw new, pain relieving, menstruation regulating, the metal-inflicted wound stasis of blood, cool blood, hemostasis; The effect of fresh rehmannia root and radix rehmanniae recen is different.Fresh rehmannia root clearing heat and promoting fluid, can stop blooding and cool blood, be often for consumption of YIN caused by febrile disease, the illnesss such as haematemesis, abscess of throat, the deep red polydipsia of tongue, a spot dermexanthesis and nosebleed heat.Relative to fresh rehmannia root, radix rehmanniae recen is heat clearing and blood cooling, also can promote the production of body fluid, all right yin-nourishing, is used for treatment yin asthenia generating intrinsic heat, hectic fever due to yin labor heat, the deep red polydipsia of tongue, sends out the problems such as spot dermexanthesis.The dried rhizome of rehmannia is cold in nature, and function is enriching yin and nourishing kidney.Not only promote the production of body fluid to quench thirst and heat clearing and blood cooling, also have effect to metrorrhagia, irregular menstruation, fetal irritability, constipation etc., every blood system has the people of thermal burn the moon, can often take.If want to treat warm heat disease, qingying decoction can be done with the dried rhizome of rehmannia; If the later stage for the treatment of warm disease, because waste heat does not also disappear to the greatest extent, the dried rhizome of rehmannia should be used for boiling Qinghao Biejia Tang; In addition, contain for blood-head poison, macula purple is black, and the serious heat of warm heat disease enters the symptom of ying blood, can take the Sisheng Wan that the dried rhizome of rehmannia is made; General want nourishing Yin and promoting production of body fluid to treat interior heat quenches one's thirst with constipation, the once liquid soup that the dried rhizome of rehmannia boils should be eaten.
Gynostemma pentaphylla finds through modern medicine study, gynostemma pentaphylla principle active component is polysaccharide, flavonoids, saponins and microelement kind, its effect mainly promotes body fat class metabolism, nutrition human body cell, there is good detoxicating, relieving inflammation effect simultaneously, be widely used in high fat of blood, fatty liver, obesity, constipation, insomnia, hepatitis B, the treatment of chronic airway inflammation (sphagitis, enterogastritis etc.) and health care.
The root of large-flowered skullcap has heat-clearing and damp-drying drug, and cool blood is antiabortive, detoxicating functions.Cure mainly warm heat disease, the infection of the upper respiratory tract, cough with lung heat, damp and hot jaundice, pneumonia, dysentery, hemoptysis, hot eyes, fetal irritability, hypertension, carbuncle swell the diseases such as furuncle sore.The clinical practice of the root of large-flowered skullcap is antibacterial not worse than the coptis, and does not develop immunity to drugs.We are by the strong feature of broad-spectrum antibacterial action, are used in fungal culture miscellaneous bacteria and infect special severe, fine by root of large-flowered skullcap extract effect." Bencao Jingshu ": the root of large-flowered skullcap, its property is respectful clearly, so evil removing: bitter is so eliminating dampness; Cold sensation of the genitalia is so victory warm, therefore main all heat.All hot persons, heat symptoms caused by an exopathgen with all over heat also, jaundice, intestines are out-of-the-way, let out dysentery, and the disease of all damp and hot victory also, analyses it, then all diseases are from recover.Bitter cold can except damp and hot, thus small intestine profit and water from by, source is clearly then flowed also clean.The blood person of closing, real heat is at blood system, and instant heating human blood room, make us obstructed through closing, damp and hot solution, then Ying Qi clearly and voluntarily also.Dislike sore subcutaneous ulcer erosion person, blood-head then stays knot, and is that the carbuncle stain that swells is also rotten: fiery ulcer person, also, cool blood heat extraction, then self-healing also for internal heat blood trouble.The root of large-flowered skullcap has antiallergic action and antiinflammatory action: the anaphylaxis contractile response that baicalin contained by the root of large-flowered skullcap and baicalein can obviously suppress sensitized guinea pig rat small intestine in vitro and isolated tracheal to produce antigen, to passive general allergy and the cavy passivity skin allergic reaction of cavy and mouse, baicalin and baicalein also have inhibitory action.The root of large-flowered skullcap has refrigeration function, and most test proves, the effective ingredient baicalein of the root of large-flowered skullcap has refrigeration function.The root of large-flowered skullcap has detoxication, and baicalin has obvious detoxication, and this may be that baicalin decomposites glucuronic acid due under the effect of glucuronidase, and caused by being combined with multiple poisonous substance.The LD 50 that baicalin 10 milligrams can improve strychnine reaches 2.5 times, and the hepatic glycogen content of carbon tetrachloride poisoning mouse is increased.
Mountain is planted mountain contained by leaf and is planted leaf flavonoids and have pharmacological action widely, is particularly useful for cardiovascular system.Experimental study shows, mountain plant leaf flavonoids have hypotensive, reduce peripheral vascular resistance, coronary artery dilator, increase coronary flow, reduce MCO, cardiac stimulant, increase cardiac output, resist myocardial ischemia, platelet aggregation-against, improve hemorheological property, eliminate oxygen radical, fall the pharmacological actions such as excellent and constitution, enhancing hypoxia-bearing capability and diuresis.Clinical is all safe and effective for preventing and treating coronary disease and angina pectoris, hypertension, arrhythmia cordis and hyperlipidemia, atherosclerotic etc., is worthy of popularization.Leaf is planted on mountain, and in China various places, particularly Resources of The West Area In China is very abundant, has very high Development volue.
Folium cortex eucommiae is the dry leaf of Eucommiaceae plant bark of eucommia Eucommia ulmoides Oliv..Summer, autumn two gather when season, branches and leaves were luxuriant, dry or low temperature drying.Micro-pungent, temperature.Return liver, kidney channel.Function with cure mainly: filling liver kidney, strengthening the bones and muscles.For kidney deficiency and liver, have a dizzy spell, soreness of waist and knee joint, muscles and bones impotence is soft.To the effect of cardiovascular system, action of the heart folium cortex eucommiae water decoction-alcohol sedimentation liquid 0.2g is significantly increased to the effect of CF to guinea pig isolated heart tool.Rabbits after intravenous note 20g/kg, the ST section caused quiet note isoprel is raised and T ripple changes and do not have antagonism.After hypotensive effect anesthetized dog and cat quiet note folium cortex eucommiae water decoction 0.4g/kg, blood pressure declines rapidly, maintains namely to go up gradually after 5 minutes; During quiet note more than 1g/kg dosage, blood pressure significantly declines, and can maintain the long period.Alcohol extract also has hypotensive effect, but Amplitude of Hypotensive and hold time all poor than water decoction.The drop test of anesthetized dog and cat all proves, folium cortex eucommiae water decoction and alcohol extract repeat Bolos intravenous administration in a short time can produce tachylaxis, and successive administration even can not occur pressure reduction effect 3-4 time.Water decoction and the quiet note of 65% ethanol extract 6g/kg of folium cortex eucommiae all can cause rabbits blood pressure obviously to decline.The aqueous solution of folium cortex eucommiae, alcoholic solution, ethereal solution and each composition such as carbohydrate, alkaloid, Aucubin, chlorogenic acid through purifying are noted to rabbits after intravenous, all have hypotensive effect in various degree.
Fructus Corni, cure mainly perverse trend fever and chills under the heart, Wen Zhong, by cold temperature numbness, goes three worms, for a long time clothes made light of one's life by commiting suicide reinforcing yin essence benefit essence, five viscera settling, logical nine orifices, stop the merit of dribbling urination; Take improving eyesight, brute force for a long time all the year round.Fructus Corni, have another name called cornus officinalis sieb et zucc, medicine jujube, real jujube, fructus corni, meat jujube etc., for China commonly uses rare traditional Chinese medicine, applicating history is long.It is gentle with its benefit power, establishing-Yang and do not help fire, enriching yin and oiliness diaphragm, convergence and do not stay evil wait special efficacy like by successive dynasties medical science use.Zhang Zhongjing is that monarch has formulated " chinkuei shin chewan pills " with Fructus Corni.According to chemical analysis, Fructus Corni contains the active ingredients such as the stronger cornin of physiologically active, tartaric acid, gallic acid, malic acid, resin, tannin and multivitamin, having and strengthen immunity, anti-inflammatory, the pharmacological action such as antibacterial, is the medicine simply commonly used in tcm clinical practice.
Radix Angelicae Sinensis, its taste is sweet and weigh, therefore specially can enrich blood, and its gas is light and pungent, therefore again can promoting circulation of blood, and bowl spares has, has benefit, the gas medicine in sincere blood, the panacea also in blood in row.Then mending to mend of about assistant, therefore can nutrition blood be supported, tonifying Qi production of sperm, five viscera settling, strong body, beneficial mind, all tangible deficient diseases, unsuitable without institute.Assistant to attack, lead to, therefore pain defaecation of dispelling, relieving rigidity of muscles and joints, controls contraction, paralysis, the card such as dry, puckery.Empty and the exterior syndrome being not relieved person of battalion, help with agent such as bavin, Pueraria lobota, fiber crops, osmanthus, can fall apart greatly Biao Weire, and show not hold back person, helps with rheum officinale and so on, can admittedly show again.Precisely because gas Xin Erdong, therefore for its quiet person when keeping away it, the sliding benefaction of property, stool does not consolidate person when keeping away it.All cloudy moderate heat Sheng persons, the active blood of Radix Angelicae Sinensis, also non-institute is suitable, and cloudy deficiency of YANG of middle-JIAO person, Radix Angelicae Sinensis can nourish blood, and is indispensable.
Ligusticum wallichii Ligusticum wallichii is pungent, temperature.Enter liver, gallbladder channel.Activating QI to alleviate the depression, method wind-dryness is wet, promoting blood circulation and stopping pain.Controlling air-cooled headache revolves dizzy, hypochondriac pain abdomen ache, arthritis muscle contraction, through closing, difficult labour, postpartum stasis blocking block pain, ulcer sores.For irregular menstruation, through closing dysmenorrhoea, lump in the abdomen is suffered from abdominal pain, the shouting pain of the chest side of body, tumbling and swelling, headache, arthralgia due to wind-dampness." herbal classic " carries it: main apoplexy enters brain headache, arthritis, muscle contraction emergency, and gold wound, married woman's blood closes s.m.p." not Lu " carries it: " except cold dynamic in brain, on face, urticaria goes, order lacrimation, profuse nasal discharge and spittle, before we notice it as liquor-saturated, all cold gas, the hard pain of trusted subordinate, middle evil, soldier is anxious to swell and ache, side of body wind pain, cold in temperature." be the good medicine of regulating qi to disperse stagnation.
Dried orange peel is warm in nature, and taste is pungent, bitter.Enter the spleen channel, stomach warp, lung channel.Regulating qi-flowing for strengthening spleen, in tune, eliminating dampness, reduces phlegm.Cure mainly abdominal fullness and distention or pain, the indigestion of the taste stagnation of the circulation of vital energy.Abdominal distension uncomfortable in chest in wet turbid resistance, indigestion and loss of appetite loose stool.The wet cough and asthma stopping up lung of phlegm.For chest gastral cavity turgor, food is few vomits and diarrhoea, coughing with a lot of sputum.Compendium of Material Medica: it is to hundred and always get chess and to regulate the flow of vital energy the merit of eliminating dampness, then mending with tonic, then rushes down with cathartic, then rise with hydrargyrum oxydatum crudum, then falling with falling medicine.Spleen is the mother of vigour, lung be take the photograph gas want, therefore orange peel be two through gas divide want, but with join and reinforcing and reducing methods lifting also." daily book on Chinese herbal medicine ": can fall apart and can rush down, can temperature can mend, can disappear diaphragm gas, and reduce phlegm saliva, and spleen is only coughed, and logical five drench.
Teasel root Chinese medicine name.For the root of Dipsacaceae herbaceos perennial teasel, gain the name because of energy " synthetism of continuous folding ".Autumn excavates, and removing root head and fibrous root, be dried to half-dried with low baking temperature, when bank up " sweating " is to inner virescence, then dries." the southern regions of the Yunnan Province book on Chinese herbal medicine ": " channels and collaterals determine in tonifying liver, strengthening the bones and muscles, only through in (muscles and bones) ache, antiabortive, control married woman leukorrhea, raw new blood, break hemostasis, fall stillborn foetus, and cough-relieving is coughed hemoptysis, controls red white turbid urine.”
Specific embodiment 1:
First plucked by the Fructus Sophorae, nine steam nine shines, and then adds honey modulation.
Again by leaves of Hawthorn, folium cortex eucommiae chopping, stir-fry.
Finally by all the other raw material gynostemma pentaphylla, the dried rhizome of rehmannia, the red sage root, Radix Angelicae Sinensis, Fructus Corni, Poria cocos, the bighead atractylodes rhizome, Ligusticum wallichii, the root bark of white mulberry, the root of large-flowered skullcap, dried orange peel, intermittently; Extract to concentrate and make granule, pulvis or paste.
The extract of the Fructus Sophorae be mixed with, leaves of Hawthorn and folium cortex eucommiae and other raw materials, ultraviolet radiation for sterilizing and disinfecting packs, and directly can take after mixing it with hot water during use.
Specific embodiment 2:
In midwinter, after the dry Fructus Sophorae being adopted down from Chinese scholar tree, clear water is cleaned, and dries, and removing impurity and dust, be placed on food steamer, add burning hot steaming; Steamed, dry; Such Continuous Heat steams nine times, airing nine times; When the Fructus Sophorae becomes aterrimus, after treating its drying, approximately obtain Fructus Sophorae 5000g, then get honey and put into pot heating, pour in pot by the Fructus Sophorae shone after honey melts, stirring loads container after cooling and dries in the shade, and sealing saves backup.
The leaves of Hawthorn 1500g of results, folium cortex eucommiae 1500g are cleaned and is cut into filament, airing, parch; Leaves of Hawthorn good for airing, folium cortex eucommiae are put into the pot that completes and gone green grass or young crops, and complete 30-45 minute at 70-100 DEG C, then puts into large iron pan and stir-fry, on first backward downwards, firmly want evenly, when leaves of Hawthorn, folium cortex eucommiae color start jaundice, start little fire stir-fry 20-30 minute shaping; Naturally dry after taking out.
Again by surplus stock gynostemma pentaphylla 1500g, dried rhizome of rehmannia 1500g, red sage root 1500g, Radix Angelicae Sinensis 1500g, Fructus Corni 1500g, Poria cocos 1500g, bighead atractylodes rhizome 1500g, Ligusticum wallichii 1500g, root bark of white mulberry 1500g, root of large-flowered skullcap 1500g, dried orange peel 1500g, interrupted 1500g, cleans impurity elimination, dries, be ground into particle, soak 1 hour;
Soaked bulk drug is put boiling secondary in multi-function extractor; Add up the water of medicinal material 10 times amount for the first time, decoct 1.5 ~ 2 hours, get decocting liquid, filter; Second time adds up the water of medicinal material 7 times amount, decocts 1 ~ 1.2 hour, gets twice decocting liquid mixing, filters; The filtrate of filtration inserted in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C, relative density is the concentrate of 1.05, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Refrigeration liquid is added the filter aid diatomite of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 1g crude drug amount, adds dextrin and make granule.The Fructus Sophorae prepared, leaves of Hawthorn and folium cortex eucommiae and the granule made are mixed, ultraviolet disinfection, packs and get final product again.
Specific embodiment 3:
In midwinter, after the dry Fructus Sophorae being adopted down from Chinese scholar tree, clear water is cleaned, and dries, and removing impurity and dust, be placed on food steamer, add burning hot steaming; Steamed, dry; Such Continuous Heat steams nine times, airing nine times; When the Fructus Sophorae becomes aterrimus, after treating its drying, approximately obtain Fructus Sophorae 4000g, then get honey and put into pot heating, pour in pot by the Fructus Sophorae shone after honey melts, stirring loads container after cooling and dries in the shade, and sealing saves backup; The leaves of Hawthorn 1200g of results, folium cortex eucommiae 1100g are cleaned and is cut into filament, airing, parch; Leaves of Hawthorn good for airing, folium cortex eucommiae are put into the pot that completes and gone green grass or young crops, and complete 30-45 minute at 70-100 DEG C, then puts into large iron pan and stir-fry, on first backward downwards, firmly want evenly, when leaves of Hawthorn, folium cortex eucommiae color start jaundice, start little fire stir-fry 20-30 minute shaping; Naturally dry after taking out; Again by surplus stock gynostemma pentaphylla 1100g, dried rhizome of rehmannia 1200g, red sage root 1100g, Radix Angelicae Sinensis 1200g, Fructus Corni 1100g, Poria cocos 1100g, bighead atractylodes rhizome 1100g, Ligusticum wallichii 1200g, root bark of white mulberry 1100g, root of large-flowered skullcap 1100g, dried orange peel 1100g, interrupted 1100g, put it in 10 times of water gagings and soak.Drop into multi-function extractor and extract twice, first time adds 8-10 times amount soak by water 1-2 hour, and second time adds 4-8 times amount soak by water 1-2 hour, merges twice decocting liquid, filters to get filtrate; Heating is concentrated into powder, then puts into baking oven inner drying powdered, and hybrid packed with the Fructus Sophorae, leaves of Hawthorn and the folium cortex eucommiae prepared after ultraviolet radiation for sterilizing and disinfecting, during use, direct boiling water is taken after mixing it with water.
Specific embodiment 4:
In midwinter, after the dry Fructus Sophorae being adopted down from Chinese scholar tree, clear water is cleaned, and dries, and removing impurity and dust, be placed on food steamer, add burning hot steaming, steamed, dry, such Continuous Heat steams nine times, airing nine times, when the Fructus Sophorae becomes aterrimus, after treating its drying, approximately obtain Fructus Sophorae 4500g, then get honey and put into pot heating, pour in pot by the Fructus Sophorae shone after honey melts, stirring loads container after cooling and dries in the shade, and sealing saves backup, the leaves of Hawthorn 1200g of results, folium cortex eucommiae 1100g are cleaned and is cut into filament, airing, parch, leaves of Hawthorn good for airing, folium cortex eucommiae are put into the pot that completes and gone green grass or young crops, and complete 30-45 minute at 70-100 DEG C, then puts into large iron pan and stir-fry, on first backward downwards, firmly want evenly, when leaves of Hawthorn, folium cortex eucommiae color start jaundice, start little fire stir-fry 20-30 minute shaping, naturally dry after taking out, again by surplus stock gynostemma pentaphylla 1200g, dried rhizome of rehmannia 1100g, red sage root 1300g, Radix Angelicae Sinensis 1300g, Fructus Corni 1200g, Poria cocos 1300g, bighead atractylodes rhizome 1200g, Ligusticum wallichii 1200g, root bark of white mulberry 1300g, root of large-flowered skullcap 1300g, dried orange peel 1300g, interrupted 1300g, add in the ethanol of 5-10 times amount and soak 1-2 hour, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extract, 100-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate reduced pressure concentration relative density is 80 DEG C 1.36 medicinal extract, heating is concentrated into paste, stand for standby use, become component 1, again the dregs of a decoction that alcohol extract is crossed are put into 10 times of water gagings, heating and refluxing extraction 2 times, each extraction time is 1 ~ 2 hour, and 100-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate reduced pressure concentration relative density is 80 DEG C 1.36 medicinal extract, heating be concentrated into paste, stand for standby use, become component 2, merge component 1 and component 2 paste making agent, the Fructus Sophorae that combination system is got ready, leaves of Hawthorn, folium cortex eucommiae pack.
Pharmacological toxicity is tested
Experimental example 1: acute toxicity test of the present invention
One, test material: animal: Kunming mouse, body weight 18-25g, male and female half and half, Shandong University's biology laboratory breeding.Medicine: the present invention's (all raw material mixing decoction 2 times merges and filters, taking liquid) is containing 0.0365mg/ml.
Two, method:
1, LD50 calculates: adopt improvement karber's method, mouse is divided into 5 groups at random, often organize 10, male and female half and half, dissolve adding distil water of the present invention, are made into Cmax, by the administration of mouse maximum permission capacity, institute is followed successively by 18,14.4 to dosage by crude drug amount, 11.5,9.2,7.4 (g.kg-1), in animal fasting (can't help water) after 18 hours, administration at twice in one day (interval half an hour), each 0.5ml, observes animal dead situation.
2, maximum tolerated dose measures (MTD value): get mouse 20, each 10 of male and female.Adding distil water of the present invention is dissolved, is made into maximum concentration, by the maximal tolerance dose of animal, feed device and can twitch to inject to fill with and be as the criterion.In animal fasting (can't help water) after 18 hours, administration at twice in one day (interval half an hour), each 0.5ml (every ml containing crude drug 0.36g), total dose is 18g crude drug/kg.d, 300 times of quite clinical adult 50Kg body weight consumption.Continuous Observation 7 days after administration.
Three, result of the test:
In LD50 calculates when giving mouse with maximum acceptable concentration and maximum permission capacity (18g/Kg.d), have no dead mouse, namely LD50 is not measured, ask maximum tolerated dose only, in 7 day observation period, its appetite of animal, activity, hair color, the state of mind etc. are all normal, grow normal, there are no death.Namely select the 300 times of doses being equivalent to clinical dosage, and have no adverse reaction, show that acute toxicity is minimum, MTD > 18g/Kg.d.
Experimental example 2: the result of the test of acute toxicity and long term toxicity
Acute toxicity test: give the present invention by the disposable gavage of small white mouse, maximum concentration 35%, maximum gavage capacity 0.4ml/10g, dosage 14g/kg (every g medicinal powder is equivalent to 10g crude drug), Continuous Observation 7 days, do not find any toxic reaction, because concentration and dosage cannot increase, therefore fail to measure the LD 50 of this medicine.Maximum tolerance determination: with maximum concentration, maximum gavage capacity, mice lavage administration 3 times, 5 hours, interval, then Continuous Observation 7 days, none example is dead.Medicinal powder dosage is > 42g/kg. day (every g medicinal powder is equivalent to 10g crude drug), calculates 420 times of the clinical consumption per day that is equivalent to be grown up by kg body weight.
Long term toxicity test: whether produce toxic reaction for observing long-term prescription, give rat the present invention respectively and raise clothes, by adult 70 times of clinical consumption per day and 35 times (i.e. 7g/kg/ day and 3.5g/kg/ day), give continuously and feed 8 weeks, have no the behavior of rat, feed, body weight appearance extremely, with control group ratio, routine blood test, hepatic and renal function, the change all without exception of various important organ, within the scope of institute's dosage, do not find any toxicity of the present invention.Confirmed by the acute and chronic toxicity test of animal, safe range of the present invention is comparatively large, is a kind of safe and reliable health products.
Pharmacological experiment:
Microcirculation experimental technique:
1. materials and methods: get 50 mouse, be divided into 5 groups at random, often organizes 10 (male and female half and half), and it is a little that control group every mouse auris dextra is coated with physiological saline; Positive controls every mouse auris dextra trains first blood-activating analgesic plaster, and test component is dosage group 600mg/kg/h in low dose group 400mg/kg/h of the present invention, the present invention, high dose 800mg/kg/h of the present invention.15min pneumoretroperitoneum injects 0.1% yellow Jackets 0.1ml/10g anesthetized animal, subsequently tail vein injection 0.1% adrenaline 0.1mL/10g, observes mouse right ear fine motion vein bore (μm) and 0.2mm immediately 2capillary net number .t checks process experimental data.
2 results and discussion
2.1. on microcirculatory impact
Compared with control group, tested group 1 pair mouse capillary open number has showed increased (P < 0.01); Tested group of 2 pairs of venule bores and capillary open number have remarkable increase (P < 0.01); Tested group of 3 pairs of mouse fine motions, vein bore and capillary open number all have increase (P < 0.01); Illustrate and be subject to reagent to improve microcirculation, have function of promoting blood circulation to disperse blood clots (table 1).
Table 1, the present invention are on the impact of mouse fine motion, vein bore and capillary open number
The present invention affects blood pressure and blood lipoid
1 materials and methods
1.1 animals used as test: Wister rat, male, body weight 200 ~ 250g; Every only about the 18 ~ 20g of Kunming mouse (male and female dual-purpose), above animal is Shandong agricultural college animal center and provides.
1.2 high-calorie feed: mixed with sucrose, refining lard by basal feed, its total amount of heat is 20.08KJ/g (protein 15%, carbohydrate 51%, fat 25%).
1.3 medicines and reagent: Fructus Sophorae 30g, lotus leaf 12g, gynostemma pentaphylla 13g, dried rhizome of rehmannia 12g, selfheal 11g, snakegourd 12g, Semen Benincasae 13g, sealwort 12g, Poria cocos 13g, bighead atractylodes rhizome 12g, red sage root 12g, root bark of white mulberry 13g, root of large-flowered skullcap 10g (purchased from Shandong College of Traditional Chinese Medicine's Baokang hospital clinic), make after water decoction-alcohol sedimentation 100% liquid for subsequent use.STZ is Sigma Products, lot number: S0130; Alloxan is Sigma Products, faces the used time is made into 1% solution with citric acid one sodium citrate buffer solution of 0.1mmol/L, pH4.2; Glipizide tablet is Hainan Jin Xiao pharmaceutical Co. Ltd product, lot number: 001213; Blood sugar kit, Cholesterol Kit, Triglyceride Reagent box and serum insulin radioimmunological kit are all purchased from Beijing Zhongsheng Biological Engineering High Technology Company.
1.4 laboratory apparatus: semi-automatic biochemical analyzer: EPPENDORF-F6124 type, Germany; Radioimmunoassay instrument: naval's Medical Devices head factory, China.
The preparation of 1.5 experimental models: the preparation of diabetic hyperlipemia rat model: rat tail vein fast injection STZ30mg/kg, feeds with basal feed, freely drinks water, and tail vein blood after 2 weeks, carries out dextrose tolerance test; Select impaired glucose tolerance rat to feed with Prof. Du Yucang high-calorie feed, continue nursing 2 months.
The preparation of diabetic mouse model: get Kunming mouse, fasting 10h, then tail vein injection alloxan 100mg/kg, gets blood from mouse orbit after 72h, surveys blood glucose value; Blood glucose value is modeling success more than 11.0mmol/L person, for later experiment.
1.6 observation indexs and method: body weight: weigh with the electronic scale that Sartorius (Germany) produces.Blood sugar: GOD-PAP method.Serum triglyceride: GPO-PAP method.Serum cholesterol: CHO13-PAP method.Above 3 indexs, all by the operation of medicine box description, are produced EPPENDORF-F6124 type semi-automatic biochemical analyzer with Germany and are measured.Serum insulin is with putting the method for exempting from, and by specification operates.
1.7 data processings: experimental data represents with-X ± S, data statistics validity adopts t inspection.
2 experimental results
2.1 the present invention are on the impact of alloxan diabetes mouse: get normal mouse 10, survey its blood glucose value, feed with conventional feed.Separately get into mould mouse 50, be divided into 5 groups at random, be i.e. model group, of the present invention group (high, medium and low dosage group) and Glipizide group, successive administration 14d.Above 6 groups of mouse orbits are got blood, are surveyed its blood glucose value by 1h after last administration.
Result shows, give with alloxan after, model group compared with normal control group mice blood sugar level significantly raises, and still maintains higher level to experiment 14d its blood sugar.Of the present invention group of blood sugar level is starkly lower than model group, shows that the present invention can make alloxan diabetes mouse blood sugar reduce (P < 0.05), but still higher than Normal group (P < 0.05).In table 2.
Table 2 the present invention is on the impact (x ± s) of alloxan diabetes mouse blood sugar
Note: compare with normal group, * P < 0.05, * * * P < 0.01; Compare with model group, △ P < 0.05, △ △ △ P < 0.001
2.3 the present invention are to the effect of diabetic hyperlipemia rat
2.3.1 the present invention is on the impact of diabetic hyperlipemia rat body weight: grouping, administration is the same, day administration 1 time, continuous gavage 30 days.Experimental session drinking water for animals and feed without restriction.
Result shows, model group body weight is apparently higher than normal group (P < 0.01), of the present invention group and Glipizide group body weight are starkly lower than model group (P < 0.01, P < 0.05), of the present invention group and Glipizide group compare indifference (P > 0.05, P > 0.05) with normal group.Illustrate that the present invention has the effect of certain reduction rat model body weight.In table 3.
Table 3 the present invention is on the impact (x ± s) of diabetic hyperlipemia rat body weight
Group N Dose Body weight (g)
Normal group 10 —— 246.00±15.84
Model group 10 —— 316.5±18.34**
Of the present invention group (low) 10 5g/kg 285.65±15.31△
Of the present invention group (in) 10 10g/kg 280.26±18.34△△
Of the present invention group (height) 10 15g/kg 270.45±17.43△△
Glipizide group 10 1.3mg/kg 272.67±19.65△
Note: compare with normal group, * * P < 0.01; △ P < 0.05, △ △ P < 0.01 is compared with model group
Clinical testing: object the application of the invention Fructus Sophorae tea, observes treatment diabetes B and merges cardiovascular pathological changes, research characteristics of incidence.Method is divided into two groups at random, observes difference before and after treatment.Once make a definite diagnosis diabetes, diabetes B time special, preferably actively controls blood sugar. softening blood vessel.Along with living standard improves gradually, life pattern changes, social senilization, and diabetes are sent out along with living standard improves gradually, and life pattern changes, and social senilization, onset diabetes rate increases gradually.Diabetes merge cardiovascular pathological changes and also increase herein by Fructus Sophorae tea medical treatment observation diabetes B merging cardio cerebrovascular affection of the present invention gradually, for clinical treatment, prevention provide foundation.
1 clinical data
1.1 physical data
The diabetes B that meets of being in hospital during selecting my institute in October, 10 ~ 2012 in 2011 merges cardio cerebrovascular affection patient 100 example, the age 45 ~ 68 (55 ± 10.41) year, male patient 48 example, female patient 52 example.In diabetes medical history 3 ~ 16 (9.11 ± 4.48) year, body weight, height, motion, diet etc. do not have notable difference, P > 0.05; wherein merge cerebral infarction patient 10 example; patients with cerebral hemorrhage 18 example, Patients with Myocardial Ischemia 40 example, cerebral blood supply insufficiency patient 32 example.Be divided into observation group and each 50 examples of control group at random.
1.2 electrocardiograms and laboratory examination
Equal routine inspection blood pressure (BP), electrocardiogram (ECG), glycosylated hemoglobin (Hbaic%), triglycerides (TG), low-density lipoprotein (LDLC), HDL fHDL after being admitted to hospital) etc.
1.3 treatment
1.3.1 conventional therapy two groups all carries out conventional therapy, positive motion, amount of exercise increases gradually, the people that takes the photograph that diet strictly limits sugar measures, the medicines such as R. concomitans insulin, melbine, glibenclamide control blood sugar. and glycemic control is at empty stomach < 6.1mmol/L, after the meal 1h≤8.3mmol/L. after the meal 2h≤7.2mmol/L. observation group except conventional therapy, do not take any health protection tea, treatment group is health protection tea of the present invention daily.Fang Yong: Fructus Sophorae 25g, leaves of Hawthorn 12g, gynostemma pentaphylla 11g, dried rhizome of rehmannia 13g, red sage root 12g, folium cortex eucommiae 11g, Radix Angelicae Sinensis 13g, Fructus Corni 13g, Poria cocos 13g, bighead atractylodes rhizome 12g, Ligusticum wallichii 13g, root bark of white mulberry 11g, root of large-flowered skullcap 13g, dried orange peel 13g, interrupted 12g.Make health tea, every day two wraps.
1.3.2 after partner treatment glycemic control ideal standard, add with health protection tea of the present invention promoting blood circulation and removing blood stasis improve microcirculation, Brain circlulation promotes to represent metabolic drug, reduce platelet aggregation medicine, complicated hypertension, hyperlipemic patients, actively control blood pressure, blood fat.Cleaning is exciting, nervous patient. suitably use downern.Family members actively coordinate, and stablize patient's mood, if desired psychological intervention.
2 results
All there is the cardio cerebrovascular affection of different situations in observation group and control group.But health tea group obviously reduces the incidence of disease, P < 0.05. has statistical significance.
3 discuss
Diabetic cerebrovascular disease change refers to cardio cerebrovascular affection concurrent on Diabetes Foundation.Be characterized in: 1. diabetes complicated cardio cerebrovascular affection mainly diabetes B, occur together or concurrent cardio cerebrovascular affection, the incidence of disease is high, is 35 times of normal person.2. age rejuvenation gradually, shifts to an earlier date about 5 years than ND.3. the death rate is high, particularly diabetes B, can up to 50%.4. atypical symptom, most asymptomatic, therefore misdiagnosis rate is high.And easily there is sudden death situation.5. easy recurrent exerbation, so the more XXL death rate.6. mostly be ischemic, account for and suffer from patient 89%, wherein lacunar the dead, can repeatedly occur cerebral infarction situation, cause cerebromalacia, encephalatrophy, occur senile dementia, reduce life quality.7. most with hypertension, therefore easily occur that hemorrhagic cerebrovascular disease becomes, case fatality rate is up to more than 90%.8. diabetic's majority occurs together high fat of blood, hypertension, high blood viscosity.More easily bring out cardio cerebrovascular affection.
Diabetes pathological change mainly occurs on trunk., clinically commonly there is the atherosis person of trunk in existing atherosclerotic, majority is age patient less than normal, and disease is rapid, and lethal dose is high.Imperfectly understand due to onset diabetes reason, so to think and heredity, metabolic disorder, endocrine disturbance etc. have certain relation, in two groups of patients, occur large area cerebral infarction patient. be all associated with hypertension, hyperlipemic patients.Disease Progressive symmetric erythrokeratodermia increases the weight of, and routine is dewatered to the ill, fall cranium pressure, improve circulation treatment, control the treatments such as high risk factor, takes a turn for the better all to some extent, but all with certain complication, can't take care of oneself.There is not death situation. consider with individual difference, medication, treatment in time, offshoot circulation foundation etc. has certain relation research to find. diabetic not only has large, medium and small atherosclerotic, and has the change of capillary vascular wall, deep white matter atherosclerotic, basilar memebrane carbohydrate deposition, lipoid degeneration, microvascular function imbalance etc.Postmortem is determined further, causes lacunar infarction Died Patients.External caliber is all at 40 ~ 500 μm. coincide with diabetic microvascular complication.
, if complication with diabetes, more easily there is vascular lesion in hyperpietic, be because 2 kinds of pathologies can occur vascular lesion, therefore occurrence probability obviously increases.Once unstable blood pressure is fixed, occurs rising sharply, very easily occur cerebral hemorrhage.According to statistics, more than 80% patient, occurs that cerebral hemorrhage is all fixed relevant with unstable blood pressure.Simultaneously complication with diabetes patient, probability is more increased and is shown by research above.Once make a definite diagnosis diabetes, diabetes B time special. preferably actively control blood sugar, softening blood vessel, glycosylated hemoglobin controls at < 7%, prevention microangiopathies.The present invention is combined the prophylactic treatment of hypertension, high fat of blood, high blood viscosity, can reduce pressure, promoting blood circulation and removing blood stasis, softening blood vessel medicine.People's amount taken the photograph by be careful in one's diet middle sugar, salt, grease of patient.Positive motion improves microcirculation, prevention cardio cerebrovascular affection.Fructus Sophorae health protection tea of the present invention effectively prevents complication to occur, improves survival rate and quality of life.Time preferably, not ill just prevention, just can improve the quality of living like this, improve fitness.

Claims (10)

1. a Fructus Sophorae tea for softening blood vessel, is characterized in that, the parts by weight of the various raw materials of described Fructus Sophorae tea comprise: the Fructus Sophorae 10 ~ 50 parts, leaves of Hawthorn 10 ~ 20 parts, gynostemma pentaphylla 10 ~ 20 parts, 10 ~ 20 parts, the dried rhizome of rehmannia, the red sage root 10 ~ 20 parts, folium cortex eucommiae 10 ~ 20 parts, Radix Angelicae Sinensis 10 ~ 20 parts, Fructus Corni 10 ~ 20 parts, 10 ~ 20 parts, Poria cocos, the bighead atractylodes rhizome 10 ~ 20 parts, Ligusticum wallichii 10 ~ 20 parts, the root bark of white mulberry 10 ~ 20 parts, the root of large-flowered skullcap 10 ~ 20 parts, dried orange peel 10 ~ 20 parts, interrupted 10 ~ 20 parts.
2. the Fructus Sophorae tea of softening blood vessel according to claim 1, it is characterized in that, the parts by weight of the various raw materials of described Fructus Sophorae tea comprise: the Fructus Sophorae 10 ~ 30 parts, leaves of Hawthorn 10 ~ 15 parts, gynostemma pentaphylla 10 ~ 15 parts, 10 ~ 15 parts, the dried rhizome of rehmannia, the red sage root 10 ~ 15 parts, folium cortex eucommiae 10 ~ 15 parts, Radix Angelicae Sinensis 10 ~ 15 parts, Fructus Corni 10 ~ 15 parts, 10 ~ 20 parts, Poria cocos, the bighead atractylodes rhizome 10 ~ 20 parts, Ligusticum wallichii 10 ~ 20 parts, the root bark of white mulberry 10 ~ 20 parts, the root of large-flowered skullcap 10 ~ 20 parts, dried orange peel 10 ~ 20 parts, interrupted 10 ~ 20 parts.
3. the Fructus Sophorae tea of softening blood vessel according to claim 1, it is characterized in that, the parts by weight of the various raw materials of described Fructus Sophorae tea comprise: the Fructus Sophorae 10 ~ 40 parts, leaves of Hawthorn 10 ~ 20 parts, gynostemma pentaphylla 10 ~ 20 parts, 10 ~ 20 parts, the dried rhizome of rehmannia, the red sage root 10 ~ 20 parts, folium cortex eucommiae 10 ~ 20 parts, Radix Angelicae Sinensis 10 ~ 20 parts, Fructus Corni 10 ~ 20 parts, 10 ~ 15 parts, Poria cocos, the bighead atractylodes rhizome 10 ~ 15 parts, Ligusticum wallichii 10 ~ 15 parts, the root bark of white mulberry 10 ~ 15 parts, the root of large-flowered skullcap 10 ~ 15 parts, dried orange peel 10 ~ 15 parts, interrupted 10 ~ 15 parts.
4. the preparation method of the Fructus Sophorae tea of softening blood vessel as described in any one of claims 1 to 3 item, it is characterized in that, the preparation process of described Fructus Sophorae tea comprises following aspect:
A. the preparation of the Fructus Sophorae;
B. the preparation of leaves of Hawthorn, folium cortex eucommiae;
C. by other raw material soaking ethanol described, extract 2 times;
D. again the concentration of liquid medicine that surplus stock extracts is become granule, pulvis or paste;
E. concentrated granule, pulvis or paste are mixed with the Fructus Sophorae prepared, be prepared into health protection tea.
5. the preparation method of the Fructus Sophorae tea of softening blood vessel according to claim 4, is characterized in that, in described step a, in midwinter, after the dry Fructus Sophorae being adopted down from Chinese scholar tree, clear water is cleaned, and dries, and removes impurity and dust, is placed on food steamer, adds burning hot steaming; Steamed, dry; Such Continuous Heat steams nine times, airing nine times; When the Fructus Sophorae becomes aterrimus, after treating its drying, get honey and put into pot heating, pour in pot by the Fructus Sophorae shone after honey melts, stirring loads container after cooling and dries in the shade, and sealing saves backup.
6. the preparation method of the Fructus Sophorae tea of softening blood vessel according to claim 4, is characterized in that, in described step b, the leaves of Hawthorn of results, folium cortex eucommiae is cleaned and is cut into filament, airing, parch; Leaves of Hawthorn good for airing, folium cortex eucommiae are put into the pot that completes and gone green grass or young crops, and complete 30-45 minute at 70-100 DEG C, then puts into large iron pan and stir-fry, on first backward downwards, firmly want evenly, when leaves of Hawthorn, folium cortex eucommiae color start jaundice, start little fire stir-fry 20-30 minute shaping; Naturally dry after taking out.
7. the preparation method of the Fructus Sophorae tea of softening blood vessel according to claim 4, is characterized in that, in described step c, surplus stock is cleaned impurity elimination, dries, be ground into particle, add in the ethanol of 5-10 times amount and soak 1-2 hour, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extract, 100-120 order filters, then is the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, when ultrafiltrate reduced pressure concentration relative density is 80 DEG C 1.36 pasty state, stand for standby use.
8. the preparation method of the Fructus Sophorae tea of softening blood vessel according to claim 4, it is characterized in that, in described steps d, the concentrate of said extracted is inserted in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C, relative density is the concentrate of 1.05, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Will refrigeration liquid add 0.3% filter aid diatomite, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 1g crude drug amount, convection drying powdered, or adds dextrin and be in harmonious proportion and make particle.
9. a preparation method for basis Fructus Sophorae tea of softening blood vessel as described in any one of claims 1 to 3 item, is characterized in that, when paste made by other raw materials of described Fructus Sophorae tea, step is:
A, get other raw materials and put into ethanol and soak, heat is extracted 2 times, and becoming paste, is component 1;
B, dregs of a decoction extracting in water 2 times, thickening filtration is paste, is component 2;
C, by also 2-in-1 to component 1 and component, be condensed into medicinal extract, after ultraviolet radiation for sterilizing and disinfecting with prepare the Fructus Sophorae and merge and pack.
10. the step of paste made by other raw materials of the Fructus Sophorae tea of softening blood vessel according to claim 9, it is characterized in that: in described step a, gets raw material and adds in the ethanol of 5-10 times amount and soak 1-2 hour, heating extraction 2 times, each 1-2 hour, removes supernatant, merges extract, 100-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate reduced pressure concentration relative density is 80 DEG C 1.36 medicinal extract, heating be concentrated into paste, stand for standby use, becomes component 1; In described step b, 10 times of water gagings put into by the dregs of a decoction crossed by alcohol extract, and then put into extractor heating and boil 1 hour, filter, filtrate is for subsequent use; Filter residue adds water, and second time heating, boils 45 minutes, and filter, filtrate is for subsequent use; 2 filtrates be combined, by filtered through gauze, add 50-60% ethanol in residue, 60 DEG C-70 DEG C are continued lixiviate 2h, and every 10min stirs once, filtered through gauze, merge leaching liquor, are condensed into pasty state, become component 2; Above-mentioned two kinds of extracts are merged by described step c, decompression recycling ethanol to be concentrated into liquor strength be 0.6g crude drug/mL, after suction filtration, when the relative density of filtrate is about 20 DEG C 1.08; Be decompressed to 0.03-0.08MPa, temperature remains on 60-80 DEG C, and being concentrated into relative density is 1.20, the medicinal extract of temperature to 60 DEG C-70 DEG C.
CN201410681588.1A 2014-11-24 2014-11-24 Pagoda tree fruit tea capable of softening blood vessels and preparation method thereof Pending CN104304602A (en)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104905267A (en) * 2015-07-08 2015-09-16 青岛恒波仪器有限公司 Semen cassiae health oral liquid capable of decreasing blood lipid and preparation method thereof
CN105192209A (en) * 2015-11-09 2015-12-30 青岛安倍康生物医药技术有限公司 Health blood vessel softening salvia leaf tea and preparation method thereof
CN105687788A (en) * 2016-03-04 2016-06-22 青岛市市立医院 Pharmaceutical composition capable of softening blood vessels and application thereof
CN106071621A (en) * 2016-06-16 2016-11-09 亳州市永刚饮片厂有限公司 A kind of candied uctus Crataegi of vessel softening and preparation method thereof

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CN103623218A (en) * 2012-08-24 2014-03-12 上海锦医堂投资管理有限公司 Body-strengthening spirit-nourishing traditional Chinese medicine composition
CN103719493A (en) * 2013-12-31 2014-04-16 青岛恒波仪器有限公司 Brain-boosting and intelligence-enhancing sealwort health-care tea and preparation method thereof
CN103948818A (en) * 2014-04-08 2014-07-30 刘新泉 Traditional Chinese medicine composition for regulating human body sub-health status and preparation method thereof

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CN1056221A (en) * 1990-04-28 1991-11-20 邵文利 A kind of method for production of Chinese scholartree's pod tea
CN1183979A (en) * 1997-07-18 1998-06-10 迟经惠 Medicine for heart blood supply system disease
CN103623218A (en) * 2012-08-24 2014-03-12 上海锦医堂投资管理有限公司 Body-strengthening spirit-nourishing traditional Chinese medicine composition
CN103719493A (en) * 2013-12-31 2014-04-16 青岛恒波仪器有限公司 Brain-boosting and intelligence-enhancing sealwort health-care tea and preparation method thereof
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104905267A (en) * 2015-07-08 2015-09-16 青岛恒波仪器有限公司 Semen cassiae health oral liquid capable of decreasing blood lipid and preparation method thereof
CN105192209A (en) * 2015-11-09 2015-12-30 青岛安倍康生物医药技术有限公司 Health blood vessel softening salvia leaf tea and preparation method thereof
CN105687788A (en) * 2016-03-04 2016-06-22 青岛市市立医院 Pharmaceutical composition capable of softening blood vessels and application thereof
CN106071621A (en) * 2016-06-16 2016-11-09 亳州市永刚饮片厂有限公司 A kind of candied uctus Crataegi of vessel softening and preparation method thereof

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Application publication date: 20150128