CN105192209A

CN105192209A - Health blood vessel softening salvia leaf tea and preparation method thereof

Info

Publication number: CN105192209A
Application number: CN201510753030.4A
Authority: CN
Inventors: 不公告发明人
Original assignee: Qingdao Anbeikang Biomedical Technology Co Ltd
Current assignee: Qingdao Anbeikang Biomedical Technology Co Ltd
Priority date: 2015-11-09
Filing date: 2015-11-09
Publication date: 2015-12-30

Abstract

The invention provides health blood vessel softening salvia leaf tea which comprises the following raw materials in parts by weight: 10 to 50 parts of salvia leaves, 10 to 20 parts of peach kernels, 10 to 20 parts of hawthorns, 10 to 20 parts of spatholobus suberctu, 10 to 20 parts of folium mori, 10 to 20 parts of fried motherwort fruit, 10 to 20 parts of chrysanthemum morifolium ramat, 10 to 20 parts of semen celosiae, 10 to 20 parts of dried radix rehmanniae, 10 to 20 parts of uncaria, 10 to 20 parts of rhizoma chuanxiong, 10 to 20 parts of fructus arctii, 10 to 20 parts of panax notoginseng, 10 to 20 parts of pericarpium citri reticulatae, 10 to 20 parts of cortex moutan and 10 to 20 parts of radices trichosanthis. The tea is dark green in soup, and the fragrance flies around; the tea tastes slightly bitter and sweet; by the adding of some traditional Chinese medicines which are capable of nourishing the liver and the kidney, taste normal and are easily accepted by people, the effects of nourishing the liver and the kidney, tonifying yin and blood, tonifying deficiency, benefiting vital essence and dispelling pathogenic wind for improving eyesight can be well achieved. The health blood vessel softening salvia leaf tea can improve micro circulation, is easily accepted by people, has a function of daily health protection, and can better achieve the effect of softening blood vessels.

Description

A kind of red sage root leaf softening blood vessel health protection tea and preparation method thereof

Technical field

The present invention relates to the health products containing deriving from plant composition, particularly a kind of red sage root leaf softening blood vessel health protection tea and preparation method thereof.

Background technology

Cardiovascular disease is a kind of disease that the modern incidence of disease is very high.If just prevention cardiovascular and cerebrovascular disease is so just simple a bit can have some deep sea fish oil capsule and pill and lecithin capsule and pill for a long time, and both cooperations are eaten better together, can softening blood vessel.But a lot of people does not like eating, and thinks dangerous, containing hormone.Market has the traditional Chinese medicine health care product of many softening blood vessels, but really can the traditional Chinese medicine health care product of softening blood vessel little, the health products of all softening blood vessels on market are possible delay vascular sclerosis at most.Moreover even if you have found, also may not suit the medicine to the illness, the problem for the treatment of cardiac and cerebral vascular diseases still will be considered carefully relatively good.Softening blood vessel method is a lot, has dietetic treatment, kinesiatrics, medicinal treatment and clinical treatment etc.These methods more or less have weak point, and what have also easily causes side effect, as diarrhoea, apocleisis etc., especially very improper to the elderly.And health treatment has easy to use, have no side effect, the features such as effect is remarkable, and extremely consumers.

Arteriosclerotic cardiovascular and cerebrovascular diseases occur gradually, many and bad life style, the accumulation environmental pollution of vivotoxin causes blood viscousness cohesion relevant, life, work strain, smoking, excessive drinking, overnutrition, blood thickness, abnormal composition (toxin) etc. in blood, severe overweight, form artery sclerosis, the DVT at vascular inflammation and initial stage, mid-term, the dysemia phase, teenager is cradle even, mid-term, angiosis becomes the interim youth of hemodynamic change and can occur, late period, SE (a sick phase) angiemphraxis of visceral organ injury phase or life is serious, cardiovascular and cerebrovascular diseases are caused more than 50%, peripheral vessels occurs, form serious hypertension, the exhaustion of severe patient life, young occur " disease of old people " increases year by year in recent years.

We are except the few oily low sodium of eating attention, lighter, take relatively good after medicine still arrives regular examination in hospital according to the guidance of doctor.If conditions permit, take some health products or functional food is also good selection.Not greasy, lighter, have some green vegetables and fruit (preferably non-harmful, a lot of disease is all caused by agricultural chemicals, chemical fertilizer, hormone now), if domestic conditions pretty good can select some health foods or functional food more.The function of health products mainly improves brain blood circulation, adheres to physical training and suitably applies psychotropic agent.The starting point for the treatment of is relief of symptoms, alleviates patient's misery, delays advancing of disease.

The red sage root (SalviamiltiorrhizaBge.) is Labiatae (Labiatae) Salvia (Salvia) plant, is used as medicine with root.Current red sage root underground part and preparation thereof are widely used in clinical, but a large amount of aerial parts is given it up.There are some researches show, red sage root overground part contains the water soluble ingredient similar to root, and aerial part is about the heavy twice of root, therefore, very necessary to the exploitation of red sage root overground part, and salvia root leaf tea is exactly a kind of mode of exploitation red sage root leaf.The present invention carries out dynamic analysis to the active ingredient in red sage root leaf, and the red sage root leaf of to gather the highest period with chemical composition content for raw material, and controls the technological parameter of salvia root leaf tea process, to develop the high-quality salvia root leaf tea containing higher active ingredient.Carry out initial analysis to the drinking method of salvia root leaf tea and antioxygenic property thereof, the popularization for salvia root leaf tea provides technical support and theory support simultaneously.

Result of study is as follows: 1, red sage root leaf moisture after August is substantially constant, and chlorophyll, carotenoid, soluble sugar, total phenol, flavonoids, vitamin C, tanshin polyphenolic acid B and Rosmarinic acid are in content peak period substantially in September to mid-October.Consider that the red sage root seals ridge in September, picking leaves does not only affect red sage root root growth during this period, is conducive to ventilation and penetrating light on the contrary; And after mid-October, red sage root leaf starts aging, various chemical composition content declines.Therefore, the suitable collection period of red sage root leaf is that September is to mid-October.2, wither the flavonoids adding red sage root leaf, total phenol and free aminoacid content, but reduce the content of soluble sugar simultaneously, therefore to note the length of withering time, thus reach the active component both improving salvia root leaf tea, greatly can not affect again the organoleptic quality of salvia root leaf tea.This research finds that the most applicable withering time of red sage root leaf is about 6h.3, by analyzing salvia root leaf tea fixing method, fresh leaf processing method to the impact of salvia root leaf tea chemical composition and organoleptic quality, show that the fresh leaf of the red sage root does not cut that to carry out steam beating effect best.4, knead the broken cell rate that can increase salvia root leaf tea, thus its water extraction content is increased, be conducive to the brewing property improving salvia root leaf tea.5, by analyzing the impact on salvia root leaf tea chemical composition and organoleptic quality of different dry drying method, show that the salvia root leaf tea quality of oven dry is better.6, test is brewed to salvia root leaf tea, show that preferably brewing conditions is: brew water temperature 100 DEG C, brew tea-water proportion 1g: 50mL, brewing time 3-5min.Wherein brew water temperature to have the greatest impact to the water extraction of salvia root leaf tea and organoleptic quality.7, the water extract of salvia root leaf tea, red sage root leaf and red sage root tea and ethanol extract in hydroxyl radical free radical clearance rate, remove in DPPH free radical, reducing power and inhibition of peroxidation etc. and all have certain effect, and the oxidation resistance of salvia root leaf tea is higher than red sage root leaf and red sage root tea, show through being processed with the raising helping salvia root leaf tea oxidation resistance.

The various health products sold on the market now, dragons and fishes jumbled together for medicine, great majority are the amusement of false propaganda, what have does not only have health-care components, also cause the huge injury of the person, therefore, search of health effective softening blood vessel method has very real significance, and softening blood vessel active material is the key that people expect to deal with problems always safely and effectively.Chinese medicine softening blood vessel, having advantage that is nontoxic, that can be absorbed completely by organism, is the Main way that we study.There are reducing blood lipid, antibacterial, hypoglycemic, antioxidation in present market in the urgent need to developing one, and energy interference body is to the absorption of fat, promotes the product that the fat taken in excretes, and has advantage that is nontoxic, that can be absorbed completely by organism.

Summary of the invention

Technical problem to be solved by this invention is, the various health products sold on the market now, dragons and fishes jumbled together for medicine, great majority are the amusement of false propaganda, what have does not only have health-care components, also cause the huge injury of the person, therefore, search of health effective softening blood vessel method has very real significance.The present invention is with red sage root leaf blade for raw material, and pure picked by hand, to be combined with prepared slices of Chinese crude drugs technique through ancient method tea-manufacturing technology and to process.Soup look of the present invention is dark green, and delicate fragrance overflows, micro-bitter glycol; Add some nourishing liver and kidney, the gentle people of making of mouthfeel is easy to the Chinese medicine accepted, and can reach that nourishing liver and kidney, beneficial the moon nourishes blood preferably, qi-restoratives benefit vital essence, dispelling pathogenic wind for improving eyesight, nourishing liver and kidney effect; The present invention is safe and effective, is worthy of popularization.Particularly Resources of The West Area In China is very abundant in China various places for the red sage root, has very high Development volue; Add some promoting blood circulation and removing blood stasis, fat and serum triglyceride are all had to the Chinese medicine of obvious reducing effect, and can microcirculation be improved, make people be easy to accept, reach the function of daily health caring, more can reach effect of softening blood vessel preferably.

For solving above-mentioned technical barrier, the invention provides a kind of red sage root leaf softening blood vessel health protection tea, described in it, red sage root leaf softening blood vessel health protection tea comprises the raw material of following parts by weight: 10 ~ 50 parts, red sage root leaf, 10 ~ 20 parts, peach kernel, hawthorn 10 ~ 20 parts, reticulate millettia 10 ~ 20 parts, 10 ~ 20 parts, mulberry leaf, stir-baked FRUCTUS LEONURI 10 ~ 20 parts, FLOS CHRYSANTHEMI ALBA from Haizhou of China 10 ~ 20 parts, seed of feather cockscomb 10 ~ 20 parts, 10 ~ 20 parts, the dried rhizome of rehmannia, the red sage root 10 ~ 20 parts, Ligusticum wallichii 10 ~ 20 parts, great burdock achene 10 ~ 20 parts, pseudo-ginseng 10 ~ 20 parts, dried orange peel 10 ~ 20 parts, the root bark of tree peony 10 ~ 20 parts, root of Chinese trichosanthes 10 ~ 20 parts.

Described red sage root leaf softening blood vessel health protection tea, in red sage root leaf softening blood vessel health protection tea described in it, the parts by weight of various raw material can be: 10 ~ 50 parts, red sage root leaf, 10 ~ 15 parts, peach kernel, hawthorn 10 ~ 15 parts, reticulate millettia 10 ~ 15 parts, 10 ~ 15 parts, mulberry leaf, stir-baked FRUCTUS LEONURI 10 ~ 15 parts, FLOS CHRYSANTHEMI ALBA from Haizhou of China 10 ~ 15 parts, seed of feather cockscomb 10 ~ 15 parts, 10 ~ 20 parts, the dried rhizome of rehmannia, the red sage root 10 ~ 20 parts, Ligusticum wallichii 10 ~ 20 parts, great burdock achene 10 ~ 20 parts, pseudo-ginseng 10 ~ 20 parts, dried orange peel 10 ~ 20 parts, the root bark of tree peony 10 ~ 20 parts, root of Chinese trichosanthes 10 ~ 20 parts.

Described red sage root leaf softening blood vessel health protection tea, in red sage root leaf softening blood vessel health protection tea described in it, the parts by weight of various raw material can also compare: 10 ~ 50 parts, red sage root leaf, 10 ~ 20 parts, peach kernel, hawthorn 10 ~ 20 parts, reticulate millettia 10 ~ 20 parts, 10 ~ 20 parts, mulberry leaf, stir-baked FRUCTUS LEONURI 10 ~ 20 parts, FLOS CHRYSANTHEMI ALBA from Haizhou of China 10 ~ 20 parts, seed of feather cockscomb 10 ~ 20 parts, 10 ~ 15 parts, the dried rhizome of rehmannia, the red sage root 10 ~ 15 parts, Ligusticum wallichii 10 ~ 15 parts, great burdock achene 10 ~ 15 parts, pseudo-ginseng 10 ~ 15 parts, dried orange peel 10 ~ 15 parts, the root bark of tree peony 10 ~ 15 parts, root of Chinese trichosanthes 10 ~ 15 parts.

For solving the problems of the technologies described above, the present invention also provides the preparation method of a kind of described red sage root leaf softening blood vessel health protection tea, and described in it, the preparation process of red sage root leaf softening blood vessel health protection tea comprises following aspect:

A.9-10 pluck the red sage root leaf middle of the month, carry out frying;

B. the red sage root leaf fried is kneaded, Titian;

C. described other raw materials pulverizing, immersion ethanol are added extraction heat;

D. again by surplus stock extract medical filtration, be condensed into granule, pulvis or paste;

E. concentrated granule, pulvis or paste are mixed with the red sage root leaf prepared, sterilizing is prepared into health care medicinal tea.

In described step a, 9-10 middle of the month can the fresh and tender red sage root leaf of picked by hand, and airing, parches; Red sage root leaf good for airing is put into the pot that completes and goes green grass or young crops, complete 20-30 minute at 70-100 DEG C, then puts into large iron pan and stir-fry, and on first backward downwards, firmly wants evenly, when red sage root leaf color starts jaundice, start little fire stir-fry 20-30 minute shaping.

In described step b, naturally dry in the shade after red sage root leaf after completing can being taken out, put into large iron pan to knead, knead on first backward downwards, firmly want evenly, when filament leaf bar rope is comparatively tight, the baking machine turning in putting into 80-100 DEG C when becoming dark brown fry 30-45 minute shaping, then put into fragrance extracting machine Titian 20-30 minute, naturally dry after taking out.

In described step c, can get other raw materials and clean impurity elimination, steep in the ethanol of 5-10 times amount, be equipped with by medicinal powder in lid stainless steel cask, add 70% ethanol, quality is 0.8-1 times of meal, and stir, moistening airtight placement more than 1 hour, makes abundant expansion; Drug sample after moistening expansion is mixed pine by filter plate gauze bag parcel again bottom percolator after paving does loose, then powder is contained with stainless steel spoon, uniform loading percolator, dress 10-12 cm thick, even by T-bar pressure, then press aforesaid operations, loading in layer, suitable pressurization, medicinal powder must not load 2/3 eminence exceeding percolator; Medicinal powder face upper cover stainless steel orifice plate fastens, and opens the baiting valve below percolator, and puts a container, then slowly add 70% ethanol; Air between medicinal powder powder to be discharged, and have ethanol to flow out about about 20L, close baiting valve, cover cylinder of filtering, dipping 24 hours, then open baiting valve and carry out diacolation, control diacolation speed and be generally 1000g medicinal material outflow 2 ~ 3ml per minute, filtrate puts into liquid container, and pours ethanol time emptying into liquid container; Percolate is merged and leaves standstill.

In described steps d, the filtrate that above-mentioned steps obtains can be inserted in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C, relative density is the concentrate of 1.05, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Refrigeration liquid is added the filter aid diatomite of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 0.1g crude drug amount; Paste after concentrated adds honey mediation and makes granule; Or convection drying makes pulvis.

In described step e, the red sage root leaf made can be mixed with other raw materials of refinement, pack after ultraviolet ray sterilization bactericidal.

For solving the problems of the technologies described above, the present invention also provides the preparation method of a kind of described red sage root leaf softening blood vessel health protection tea, the preparation process of all the other raw materials can also be: get other raw materials clean dry, in 70 DEG C of baking ovens, dry 8-12h, taking-up is placed in cooling in drying box, pulverizes 80-100 mesh sieve with pulverizer; To be soaked the particle that sieves in water 12 hours, then put into extractor heating and boil 1 hour, filter, filtrate is for subsequent use; Filter residue adds water, and second time heating, boils 45 minutes, and filter, filtrate is for subsequent use; Filter residue adds water again, and half an hour is boiled in third time heating, filters, and heating is concentrated into paste, stand for standby use; Paste extract is placed in 70-90% ethanol and soaks 1-2 hour, in water-bath, be heated to 60 DEG C-70 DEG C, lixiviate 2h, every 10min stirs once, by filtered through gauze, add 50-60% ethanol in residue, 60 DEG C-70 DEG C are continued lixiviate 2h, every 10min stirs once, filtered through gauze, merges leaching liquor, is condensed into pasty state filtrate, insert in economic benefits and social benefits vacuum concentrator again, the paste after concentrated adds honey mediation and makes granule; Or convection drying makes pulvis.

Detailed description of the invention

Study and screen the Chinese herbal medicine of effective single proved recipe and softening blood vessel, and pay attention to the research of effective therapy among the people; Strengthen the research to differentiation of tcm and the rules for the treatment of; The reasonable coordination of combination of Chinese tradiational and Western medicine composite treatment, and the research of various rehabilitation therapy (as acupuncture, the qigong, massage, dietotherapy, smoked to wash, steam bath, acupuncture points external application etc.); Strengthen the early prevention of complication, early diagnosis, early treatment research, and note cultivating and improving medical personnel's professional skill and scientific research qualities.Opinion controls rule, verifies and screens effective rules for the treatment of and square medicine, objective evaluation Chinese Herbs and the mechanism of action, avoid the assumption of predictive.Actively should introduce international advanced technological means, integrate with world level, constantly update traditional Chinese medicine diagnoois and test index.

The dried rhizome of rehmannia: the dried rhizome of rehmannia is also radix rehmanniae recen, the fresh or dry block root of Scrophulariaceae herbaceos perennial glutinous rehmannia RehmanniaglutinosaLibosch..Heat-clearing, promote the production of body fluid, moisturize, laxation, the broken stasis of blood, raw new, pain relieving, menstruation regulating, the metal-inflicted wound stasis of blood, cool blood, hemostasis; The effect of fresh rehmannia root and radix rehmanniae recen is different.Fresh rehmannia root clearing heat and promoting fluid, can stop blooding and cool blood, be often for consumption of YIN caused by febrile disease, the illnesss such as haematemesis, abscess of throat, the deep red polydipsia of tongue, a spot dermexanthesis and nosebleed heat.Relative to fresh rehmannia root, radix rehmanniae recen is heat clearing and blood cooling, also can promote the production of body fluid, all right yin-nourishing, is used for treatment yin asthenia generating intrinsic heat, hectic fever due to yin labor heat, the deep red polydipsia of tongue, sends out the problems such as spot dermexanthesis.The dried rhizome of rehmannia is cold in nature, and function is enriching yin and nourishing kidney.Not only promote the production of body fluid to quench thirst and heat clearing and blood cooling, also have effect to metrorrhagia, irregular menstruation, fetal irritability, constipation etc., every blood system has the people of thermal burn the moon, can often take.If want to treat warm heat disease, qingying decoction can be done with the dried rhizome of rehmannia; If the later stage for the treatment of warm disease, because waste heat does not also disappear to the greatest extent, the dried rhizome of rehmannia should be used for boiling Qinghao Biejia Tang; In addition, contain for blood-head poison, macula purple is black, and the serious heat of warm heat disease enters the symptom of ying blood, can take the Sisheng Wan that the dried rhizome of rehmannia is made; General want nourishing Yin and promoting production of body fluid to treat interior heat quenches one's thirst with constipation, the once liquid soup that the dried rhizome of rehmannia boils should be eaten.

Peach kernel bitter, sweet, flat.The thoughts of returning home, liver, large intestine channel.Promoting blood circulation, relaxes bowel, relieving cough and asthma.For through closing, dysmenorrhoea ， wei lump in the abdomen lump in the abdomen, injury from falling down, the dry constipation of intestines.Peach kernel extract obviously can increase cerebral blood flow (CBF), increases the CBF of dog femoral artery, reduces vascular resistence, improves hemodynamic situation.Extract can improve the liver surface microcirculation of animal, and promotes choleresis.Peach kernel can make the hemorrhage of mouse and clotting time obviously extend, and decoction has inhibitory action to external thrombus, and decocting liquid has fiber facilitation.Containing the fat oil Castor Oil enteron aisle of 45% in peach kernel, be beneficial to defecation.Peach kernel can promote primipara's uterine contractile and hemorrhage.Water decoction and extract have analgesia, anti-inflammatory, antibacterial, anti-allergic effects.Amarogentin in peach kernel has the effect of antitussive and antiasthmatic and anti-hepatic fibrosis.Peach kernel bitter but sweet flavor and property are put down, and can enter the heart, liver, large intestine, and promoting blood circulation effect is very wide, availablely control the various worn-out disease of stagnation of blood stasis.In treatment, be good at treating internal carbuncle, as lung carbuncle; Acute appendicitis is often held as wanting key medicine, is the peculiar performance Yu of its tool.The many matter profits of fat, the merit that tool relaxes bowel, only in recent years clinical specially with the then less use that relaxes bowel.Menorrhalgia and contraindication in pregnancy.

Reticulate millettia property is bitter, sweet, temperature.Return liver, kidney channel, enrich blood, invigorate blood circulation, dredging collateral.For irregular menstruation, the deficiency of blood is sallow, paralysis and numbness, and arthralgia due to wind-dampness is activated blood and relaxed tendons; Nourishing blood for regulating menstruation, supplementary Amplifications of the Compendium of Materia Medica carries it can cure numb in every limb; Quadriplegia; Arthralgia due to wind-dampness; Women has through uncomfortable; Dysmenorrhoea.External application is the gynaecology's good medicine activated blood circulation and dispersed blood clots.

The flat liver of yncaria stem with hooks heat-clearing; Relieving convulsion and spasm.The hemodynamic Effects of rhynchophyllin to Conscious Rat shows: LVSP, Vmax, dp/dtmax significantly declines immediately, its fall is respectively one 7.8%, one 15.9% and 1 23.2%, do not maintain 5,10,20 minutes not etc., then level before medicine is returned to gradually, and before being significantly higher than administration when LVSP to 90 minute.SAP, DAP and MAP also all significantly decline immediately, what wherein SAP declined hold time rear two short, recovered in 30 minutes time, though DAP also slightly went up 30 minutes time, to 60 minutes again lower than normally, and MAP in observation always lower than normal level.The absolute value declined from SAP and DAP and percentage, DAP is all greater than SAP.LVEDP obviously rises when just giving medicine, is brought down below again level before medicine after 1 minute.HR significantly declines immediately, and its maximum changing value is one 35.3%, level be always starkly lower than medicine in 90 minutes that observe before.LVP-(dp/dtmax) P-1LOOP obviously reduces, and with the most obvious when 1 minute after medicine, recovers normal subsequently gradually.Be used for the treatment of high blood pressure and have certain curative effect.According to the observations of more than 100 examples, after taking medicine, most of patients blood pressure all has decline in various degree, and being down to of having is normal or close to normal range (NR).Along with the decline of blood pressure, subjective symptoms is also corresponding alleviates or disappear for dizzy, headache, nervous, shortness of breath, insomnia etc.Observe according to some cases, blood pressure decline start from taking medicine after 2-7 day, after 10 days, antihypertensive effect is namely very remarkable, sometimes also can continue to decline.The curve that blood pressure declines be ramped shaped, display this product action temperature with.Single cases has rise phenomenon at period in a medicine, but the amplitude of fluctuation is very little, and without severity of symptoms." detailed outline ": the large number of people revolves dizzy, suppressing liver-wind, except heart heat, fishes stomachache in children's, sends out macula.

Stir-baked FRUCTUS LEONURI: " detailed outline " carries Semen Leonuri, and the person of spending in vain enters gas and divides, and pale reddish brown person enters blood system.Control women's passages through which vital energy circulates uncomfortable, tire produces all diseases of all vim and vigour, and quality goods also.And hospital is fresh knows use, Shi Zhenchang with control people with four things, all medicines of rhizoma cyperi, obtain effect a lot of.Lid envelope green blood, blood stored in the liver, this thing can be invigorated blood circulation tonifying yin, therefore can improving eyesight.Benefit essence.Menstruation regulating, controls all diseases of woman also." detailed outline ": control wind antipyretic, pleasantly invigorates blood circulation, the nourishing the liver benefit heart, and peace soul determine soul, tune woman passages through which vital energy circulates, under metrorrhagia band, and all diseases before postpartum tire.Hypotensive effect.Stir-baked FRUCTUS LEONURI water-leach liquor or alcohol-water-leach liquor have slight hypotensive effect to the injection of anesthesia arteriovenous.

Poria cocos taste is sweet, light, property is put down, and is used as medicine and has the function of clearing damp and promoting diuresis, beneficial spleen and stomach, antitoxic heart-soothing and sedative.Modern medicine study: Poria cocos energy enhanced machine body immunity function, pachymaran has significantly antitumor and protect the liver dirty effect.Poria cocos slightly sweet flavor is put down, and enters the heart, lung, the spleen channel.There is eliminating dampness and diuresis, strengthening the spleen and stomach, effect of antitoxic heart-soothing and sedative.Can control difficult urination, oedema turgor, phlegm and retained fluid is coughed inverse, vomits inverse, and vomiting during early pregnancy, has loose bowels, seminal emission, stranguria with turbid discharge, palpitation with fear, forgetful disease such as grade.The Li Shui of Poria cocos, is reached by strong fortune spleen PFT, different from the Chinese medicine of other direct Li Shui.For splenasthenic diarrhea, the lower Poria cocos of band can invigorating the spleen, again can excreting dampness, and for having loose bowels caused by insufficiency of the spleen dysfunction of the spleen in transportation and transformation, being with down, application Poria cocos has the effect of giving consideration to both the incidental and fundamental, the compatibilities such as normal and Radix Codonopsis, the bighead atractylodes rhizome, Chinese yam.Can be used as tonifying lung spleen, control the adjuvant of the deficiency of vital energy.

Great burdock achene, Chinese medicine name.For the dry mature fruit of composite family biennial herb plant burdock (formal name used at school: ArctiumlappaL.).There is dispelling wind and heat from the body, a surname's lung promoting eruption, relieve sore throat dissipating bind, effect of removing toxicity for detumescence.Belong to wind-heat-dispersing medicinal in diaphoretic medicine.Modern study, great burdock achene also can be used for preventing and treating diabetic nephropathy; The Arctigenin that Arctium lappa fruit generates through hydrolysis containing arctiin has active anticancer." Bencao Jingshu ": dislike real, for loose wind is except the key medicine of thermal detoxification.Pungent can dissipating bind, hardship can expel the heat-evil, and the loose then visceral-qi of thermojunction is clear and bright, therefore improving eyesight and bowl spares.The institute of wind hinders, and defending gas must stop up, stop up then generate heat, Xin Liang dismiss then show gas and, wind without stay.Hide the swollen all impotences of device main air poison; The main moistening lung of element, dissipating bind gas, relieve sore throat diaphragm, peeling skin wind, logical twelve channels and collaterals person, know this meaning ear.Therefore in order to control urticaria, variola, especially obtain and very test." medicineization justice ": great burdock achene can rise and can fall, power relieving heat toxin.Bitter can relieve inflammation or internal heat, be with pungent can dispelling wind, cure mainly top wind phlegm, the edema of the face, discomfort in the throat, all scorchingly hot heap soil or fertilizer over and around the rootss, sabre scrofula, neck subcutaneous nodule, blood-head acne, time row measles, urticaria, all lung channel stagnated fire, wind and heat in the lung meridian, knows and should use this.

Hawthorn, stone fruit, caryoplasm is hard, and pulp is thin, and taste is micro-sour and astringent.Fruit is raw-eaten or make preserved fruit fruitcake, can be used as medicine after drying, Chinese distinctive medicine fruit dual-purpose seeds, there is the effects such as reducing blood lipid, blood pressure, cardiac stimulant, arrhythmia, also be simultaneously the good medicine of spleen benefiting and stimulating the appetite, relieving dyspepsia, phlegm reduction of blood circulation promoting, the disease such as, hernia, blood stasis full to chest diaphragm spleen, amenorrhoea has good curative effect.Flavone compound Vitexin in hawthorn is the medicine that a kind of antitumaous effect is stronger, and its extract all has certain effect to growth of cancer cells, propagation and infiltration metastasis in suppression body.

Pseudo-ginseng, Chinese medicine name.For the dry root welding technology of panax araliaceae plant Panaxnotoginseng (Burk.) F.H.Chen.Autumn excavates before the flowers are in blossom, cleans, and separately main root, a root and rhizome, dry.Supporting root is practised and is claimed " rib ", and rhizome is practised and claimed " clip ".Compendium of Material Medica: styptic powder blood analgesic therapy, golden sword arrow wound, fall flutter cane sore, blood goes out more than person, chew rotten painting, or for mixing it in end, namely its blood stops.Also main hematemesis and epistaxis, lower blood bloody flux, metrorrhagia incessant menorrhea, postpartum extravesated blood not under, blood fortune blood pain, Akamu carbuncle swell, tiger stings all diseases of snakebite." book on Chinese herbal medicine is looked for the truth ": specially enter liver stomach.Double enter heart large intestine.Have another name called mountain paint.Shi Zhen says.Or cloud energy alloy sore.As painted sticky thing also.

Dried orange peel, Chinese medicine name.For the dry mature skin of rutaceae orange CitrusreticulataBlanco and variety thereof.Medicinal material is divided into " dried orange peel " and " citrus chachiensis hortorum ".Harvesting ripe fruit, strips pericarp, dries or low temperature drying.Regulating qi-flowing for strengthening spleen is eliminating dampness and eliminating phlegm.For abdominal fullness and distention, food is few vomits and diarrhoea, coughing with a lot of sputum.Be equal to use with rhizoma atractylodis, the bark of official magnolia, for middle burnt cold-dampness taste stagnation of the circulation of vital energy person, abdominal distention, n and V, have loose bowels." Mingyi Bielu ": lower gas, preventing or arresting vomiting.

FLOS CHRYSANTHEMI ALBA from Haizhou of China is name little Tang Huang, feverfew also, is the special product in area, Tongxiang.The Chu chrysanthemum in it and Anhui, Bo chrysanthemum, the bosom chrysanthemum in Henan is all that the tea that China is famous uses chrysanthemum.Hang Ju in state-owned long cultivation history." Hang Bai tribute chrysanthemum " one is to carrying with " Dragon Well tea well-known tea ".Ancient times once made tribute.Hang Bai FLOS CHRYSANTHEMI ALBA from Haizhou of China lobe is as white as polished jade, and pistil is yellow as proof gold.Very high medical value, the effect of promoting longevity, " mending agriculture book " carries: " the sweet temperature of camomile property, clothes are the most useful for a long time." Yuan Dynasty's " Amplification on Materia Medica addendum " says: " tonifying yin of FLOS CHRYSANTHEMI ALBA from Haizhou of China energy ".Li Shizhen (1518-1593 A.D.) Compendium of Material Medica road: sharp five arteries and veins of chrysanthemum energy, adjusts four limbs, controls a wind-heat and mend; Also record one section of mythology: " angle passes on a message, Kang Fengzi, all the becoming an immortal to take chrysanthemum of Zhu child ".Effect of visible FLOS CHRYSANTHEMI ALBA from Haizhou of China.Practice city's FLOS CHRYSANTHEMI ALBA from Haizhou of China, also can for tea-drinking use, its color, smell and taste are not second to Longjing tea.Often drink, can capillary resistance be strengthened, suppress the general character of capillary, play the effect that anti-inflammatory is kept fit.

Root of Chinese trichosanthes is the root of cucurbitaceous plant Chinese juniper beach wormwood, is a kind of Chinese medicine, and be clearing heat-fire class medicine, its concrete effect is clearing heat-fire, promotes the production of body fluid to quench thirst, and apocenosis is subsided a swelling.Cure mainly: control pyreticosis thirsty, quench one's thirst, jaundice, dryness of the lung hemoptysis, carbuncle are swollen, hemorrhoid impotence.For treatment diabetes, conventional it and drugs for nourishing yin with the use of, to reach the effect for the treatment of both principal and secondary aspect of disease." book on Chinese herbal medicine converge with speech ": root of Chinese trichosanthes, it is hot and suffocating to move back the five internal organs, and as internal heat is contained and dry tongue and mouth, lung-fire is contained and the swollen larynx numbness of pharynx, and spleen fire is contained and dispute tooth swells, and convulsive seizure due to phlegm-fire is contained and cough is not peaceful.Walk note if the side of body of irascibility is swollen, the hectic fever due to yin dysphoria with smothery sensation of kidney fire, or ulcer is not burst, and hot poison does not fall apart, or five subcutaneous ulcer yellow skin and eyes, and if if the pouring of little water is puckery, be all intimately caused by pent-up, convulsive seizure due to phlegm-fire, falls in only this agent energy relieving stagnation, and can control it.Its property is sweet cold again, kindly can control thirsty, and control empty thirsty from tonic, control fire from the medicine of a cold nature thirsty, control yearningly strongly fragrant from gas medicine, controlling polydipsia from blood medicine, is control thirsty key medicine also.

The root bark of tree peony, has another name called moutan bark, Chinese medicine name.For the dry root skin of ranunculaceae peony.Originate in the ground such as Anhui, Shandong.Autumn excavates root, and removing radicula, strips root skin, dry.Life is used or is fried and uses.Compendium of Material Medica: " nourishing Yin and falling fire, separate spot poison, throat, diuresis stasis.Descendant specially controls fire mutually with yellow tiller, does not know that the merit of the root bark of tree peony more wins also.Red colored person's profit, the person of spending in vain mends, and people also seldom realizes, and should distinguish it." modern study, contained paeonol and glucosides constituents in addition thereof all have antiinflammatory action; The methanolic extract of moutan bark has suppression Platelet; Paeonol has the effects such as central inhibitory action and antiatherosclerosis, diuresis, antiulcer such as calmness, cooling, antipyretic, analgesia, spasmolysis.

Ligusticum wallichii is usually used in blood-activating and qi-promoting, wind-expelling pain-stopping, Main Cultivation in Sichuan, Yunnan, Guizhou, Guangxi, the ground such as Hubei.The pungent temperature of Ligusticum wallichii is fragrant dry, walks and does not keep, can go loose, and the up mountain peak that reaches is pushed up; Enter blood system again, descendingly reach the sea of blood.Promoting blood circulation effect is extensive, the suitable various illness of stagnation of blood stasis; Wind-expelling pain-stopping, effectiveness is excellent, can control a disease such as wind headache, arthralgia due to wind-dampness.It is gas medicine in blood that former times people calls Ligusticum wallichii, the functions such as pungent loose, the Xie Yu of its residence of dangerous speech, sensible, pain relieving.To effect 2.1 pairs of action of the heart Ligusticum wallichii decoctions of cardiovascular system to Isolated Toad and frog heart, concentration at 1O-5-10-4 time make that contractive amplitude increases, heart rate is slightly slow.By the test of EnglmannShi method, Ligusticum wallichii 20 or 30g/kgig, also make frog heart amplitude in place increase, decreased heart rate; With 40g/kgig, then the frog heart can be made to stop fighting.Ligustrazine iv also has cardiotonic to anesthetized dog, with increased heart rate.Remove vagal heart, significant reaction is still had to ligustrazine.Vertebral artery injects larger dose ligustrazine, and its Cardiovascular is not obvious.Award inderal or reserpinization in advance, can eliminate ligustrazine completely to action of the heart, therefore ligustrazine is to action of the heart, may be by caused by sympathetic nerve indirect excitation heart B acceptor." detailed outline ": eliminating dampness, antidiarrheal dysentery, activating QI to alleviate the depression.Rhizome of chuanxiong Qiong, in blood, gas medicine also, liver bitter anxious with pungent benefit it, therefore deficiency of blood person should it; Pungent to fall apart it, therefore obstruction of the circulation of vital energy person should it.

The mature seed that seed of feather cockscomb (Semencelosiae) is amaranthaceous plant annual herb feather cockscomb.All there is wild or cultivation in most of China area.The seed of feather cockscomb is one of conventional a herb of the traditional Chinese medical science, has heat of dispeling the wind, clearing away the liver-fire, moves back effect of screen." herbal classic is met former ": " seed of feather cockscomb, controls wind-heat order disease, same with cassia seed merit.It is controlled wind scabies body and itches, heat in skin, with the wind-heat of the JUE YIN meridian invasion of vessels that can fall apart also." modern clinic also can be used for disease such as treatment hypertension etc.But the empty order disease of liver is unsuitable alone, and mydriasis, glaucoma patient prohibit clothes.

Mulberry leaf are dry leaves of moraceae plants mulberry.Gather after first frost, removing impurity, drying and obtain, is a kind of wind-heat-dispersing medicinal, both oral administration, also can external application.It is cold in nature, and taste is sweet, bitter, has dispelling wind and heat from the body, clearing away the lungheat and moisturizing, the effect of clearing liver and improving vision, can treat anemopyretic cold, lung-heat type cough, dizziness headache, the illness that hot eyes is dim-sighted.In modern times, doctor trained in Western medicine uses mulberry leaf and mulberry leaf biologic product as the medicine improving diabetes and other various difficult and complicated cases, thinks that its drug effect is very extensive.There are clearing away the lungheat and moisturizing, cough-relieving, reduce phlegm and internal heat, reduce phlegm, control night sweat; Tonifying liver, clear liver and improve vision, treat dizzy, insomnia, eliminate eye strain; Detumescence, purify the blood ' treatment dysentery, stomachache, fat-reducing, except beriberi, sharp large and small intestines; Resisting stress, cool blood, hypotensive, reducing blood lipid, prevention miocardial infarction, cerebral hemorrhage, dispel headache, long hair; Hypoglycemic, anti-sugar is sick.

Specific embodiment 1:

9-10 plucks the red sage root leaf middle of the month, is prepared, stir-fries, kneads, Titian, stand-by;

Again by all the other raw material peach kernels, hawthorn, reticulate millettia, mulberry leaf, stir-baked FRUCTUS LEONURI, FLOS CHRYSANTHEMI ALBA from Haizhou of China, seed of feather cockscomb, the dried rhizome of rehmannia, yncaria stem with hooks, Ligusticum wallichii, great burdock achene, pseudo-ginseng, dried orange peel, the root bark of tree peony, root of Chinese trichosanthes, extracts and makes paste.

Two kinds of extract mixing, ultraviolet radiation for sterilizing and disinfecting packs.

Specific embodiment 2:

9-10 picked by hand in the middle of the month fresh and tender red sage root leaf 5000g, airing, parches; Red sage root leaf good for airing is put into the pot that completes and goes green grass or young crops, complete 30-45 minute at 70-100 DEG C, then puts into large iron pan and stir-fry, and on first backward downwards, firmly wants evenly, when red sage root leaf color starts jaundice, start little fire stir-fry 20-30 minute shaping.Put into fragrance extracting machine Titian 30-45 minute after being kneaded by the red sage root leaf fried, naturally dry after taking out.

Get other raw material peach kernels 1500g, hawthorn 1500g, reticulate millettia 1500g, mulberry leaf 1500g, stir-baked FRUCTUS LEONURI 1500g, FLOS CHRYSANTHEMI ALBA from Haizhou of China 1500g, seed of feather cockscomb 1500g, dried rhizome of rehmannia 1500g, yncaria stem with hooks 1500g, Ligusticum wallichii 1500g, great burdock achene 1500g, pseudo-ginseng 1500g, dried orange peel 1500g, root bark of tree peony 1500g, root of Chinese trichosanthes 1500g, add in the ethanol of 5-10 times amount and soak 1-2 hour, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extract, 100-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate reduced pressure concentration relative density is 80 DEG C 1.36 medicinal extract, heating is concentrated into paste, stand for standby use, become component 2.Component 1 and component 2 mixing are inserted in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C, relative density is the concentrate of 1.05, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Refrigeration liquid is added the filter aid diatomite of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 0.1g crude drug amount, and then add dextrin and be in harmonious proportion, ultraviolet disinfection makes particle, and prepares the merging of red sage root leaf, packs and get final product.

Specific embodiment 3:

9-10 picked by hand in the middle of the month fresh and tender red sage root leaf 3500g, airing, parches; Red sage root leaf good for airing is put into the pot that completes and goes green grass or young crops, complete 30-45 minute at 70-100 DEG C, then puts into large iron pan and stir-fry, and on first backward downwards, firmly wants evenly, when red sage root leaf color starts jaundice, start little fire stir-fry 20-30 minute shaping.Put into fragrance extracting machine Titian 30-45 minute after being kneaded by the red sage root leaf fried, naturally dry after taking out.Get other raw material peach kernels 1100g, hawthorn 1100g, reticulate millettia 1100g, mulberry leaf 1200g, stir-baked FRUCTUS LEONURI 1100g, FLOS CHRYSANTHEMI ALBA from Haizhou of China 1100g, seed of feather cockscomb 1100g, dried rhizome of rehmannia 1200g, yncaria stem with hooks 1100g, Ligusticum wallichii 1100g, great burdock achene 1100g, pseudo-ginseng 1100g, dried orange peel 1100g, root bark of tree peony 1100g, root of Chinese trichosanthes 1100g, cleans impurity elimination, steeps in the ethanol of 5-10 times amount, medicinal powder is equipped with in lid stainless steel cask, add 70% ethanol, quality is 0.8-1 times of meal, stirs, moistening airtight placement more than 1 hour, makes abundant expansion; Drug sample after moistening expansion is mixed pine by filter plate gauze bag parcel again bottom percolator after paving does loose, then powder is contained with stainless steel spoon, uniform loading percolator, dress 10-12 cm thick, even by T-bar pressure, then press aforesaid operations, loading in layer, suitable pressurization, medicinal powder must not load 2/3 eminence exceeding percolator; Medicinal powder face upper cover stainless steel orifice plate fastens, and opens the baiting valve below percolator, and puts a container, then slowly add 70% ethanol; Air between medicinal powder powder to be discharged, and have ethanol to flow out about about 20L, close baiting valve, cover cylinder of filtering, dipping 24 hours, then open baiting valve and carry out diacolation, control diacolation speed and be generally 1000g medicinal material outflow 2 ~ 3ml per minute, filtrate puts into liquid container, and pours ethanol time emptying into liquid container; Percolate is merged and leaves standstill; Filtrate above-mentioned steps obtained is inserted in economic benefits and social benefits vacuum concentrator, and when being concentrated into 90 DEG C, relative density is the concentrate of 1.05, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Refrigeration liquid is added the filter aid diatomite of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 0.1g crude drug amount; Paste after concentrated adds honey mediation and makes granule; Or convection drying makes pulvis.The red sage root leaf of mixing Titian, ultraviolet disinfection, packs and get final product.

Pharmacological toxicity is tested

Experimental example 1: acute toxicity test of the present invention

One, test material: animal: Kunming mouse, body weight 18-25g, male and female half and half, Shandong University's biology laboratory breeding.Medicine: the present invention's (all raw material mixing decoction 2 times merges and filters, taking liquid) is containing 0.0365mg/ml.

Two, method:

1, LD50 calculates: adopt improvement karber's method, mouse is divided into 5 groups at random, often organize 10, male and female half and half, dissolve adding distil water of the present invention, are made into Cmax, by the administration of mouse maximum permission capacity, institute is followed successively by 18,14.4 to dosage by crude drug amount, 11.5,9.2,7.4 (g.kg-1), in animal fasting (can't help water) after 18 hours, administration at twice in one day (interval half an hour), each 0.5ml, observes animal dead situation.

2, maximum tolerated dose measures (MTD value): get mouse 20, each 10 of male and female.Adding distil water of the present invention is dissolved, is made into maximum concentration, by the maximal tolerance dose of animal, feed device and can twitch to inject to fill with and be as the criterion.In animal fasting (can't help water) after 18 hours, administration at twice in one day (interval half an hour), each 0.5ml (every ml containing crude drug 0.36g), total dose is 18g crude drug/kg.d, 300 times of quite clinical adult 50Kg body weight consumption.Continuous Observation 7 days after administration.

Three, result of the test:

In LD50 calculates when giving mouse with maximum acceptable concentration and maximum permission capacity (18g/Kg.d), have no dead mouse, namely LD50 is not measured, ask maximum tolerated dose only, in 7 day observation period, its appetite of animal, activity, hair color, the state of mind etc. are all normal, grow normal, there are no death.Namely select the 300 times of doses being equivalent to clinical dosage, and have no adverse reaction, show that acute toxicity is minimum, MTD > 18g/Kg.d.

Experimental example 2: the result of the test of acute toxicity and long term toxicity

Acute toxicity test: give the present invention by the disposable gavage of small white mouse, maximum concentration 35%, maximum gavage capacity 0.4ml/10g, dosage 14g/kg (every g medicinal powder is equivalent to 10g crude drug), Continuous Observation 7 days, do not find any toxic reaction, because concentration and dosage cannot increase, therefore fail to measure the LD50 of this medicine.Maximum tolerance determination: with maximum concentration, maximum gavage capacity, mice lavage administration 3 times, 5 hours, interval, then Continuous Observation 7 days, none example is dead.Medicinal powder dosage is > 42g/kg. day (every g medicinal powder is equivalent to 10g crude drug), calculates 420 times of the clinical consumption per day that is equivalent to be grown up by kg body weight.

Long term toxicity test: whether produce toxic reaction for observing long-term prescription, give rat the present invention respectively and raise clothes, by adult 70 times of clinical consumption per day and 35 times (i.e. 7g/kg/ day and 3.5g/kg/ day), give continuously and feed 8 weeks, have no the behavior of rat, feed, body weight appearance extremely, with control group ratio, routine blood test, hepatic and renal function, the change all without exception of various important organ, within the scope of institute's dosage, do not find any toxicity of the present invention.Confirmed by the acute and chronic toxicity test of animal, safe range of the present invention is comparatively large, is a kind of safe and reliable health products.

Pharmacological experiment:

Red sage root leaf; Softening blood vessel; Experimental study red sage root leaf has the merit of tonifying Qi benefit the moon, invigorating the spleen, moistening lung, kidney-nourishing, containing compositions such as polysaccharide, compound sugar, several amino acids, modern pharmacological research shows, red sage root leaf decocting liquid has the effect reducing blood sugar and blood fat to rabbit experiment diabetes and hyperlipidemia, now for further study to its softening blood vessel effect, for Clinical practice red sage root leaf provides theoretical foundation.

1 Specimen origin in June ,-2014 in June, 2010 my routine inpatient of the institute 395 and serum specimen of Physical Examination person.Wherein female 69 example, wherein ischemic cerebral disease 67 example, cerebral infarction 103 example, coronary heart disease 77 example, acute myocardial infarction AMI 37 example, diabetes 44 example.Control group is 67 man 325 examples.11 ~ 89 years old age.All cases, all through clinical definite, get rid of the Physical Examination person of arteriosclerotic cardiovascular and cerebrovascular disease and diabetes between 16 ~ 88 years old.12h vein haemospasia on an empty stomach, separation of serum.

2 assay method serum Folate, VB12 concentration Roche kits adopt electrochemical luminescence method to detect on E170 automatic lmunoassays analyzer; Serum Hcy concentration adopts Enzymatic cycling to detect on Hitachi 7600 automatic clinical chemistry analyzer, and Glu, CH, Tg, Apoa, ApoB, HDL-CH, LDL-CH, UN, Cr, Ua, Lpa, Gruc, Cys detect on Hitachi 7600 automatic clinical chemistry analyzer.

3 statistical data analysis represent with mean-x ± s standard deviation, carry out significance test with One-WayANOVA, and related check adopts Spearman rank correlation.

Result

The relation of 1 serum Hcy, FOLATE, VB12 concentration and biochemical indicator.Serum Hcy and Folate, VB12, ApoA, HDL-CH concentration are negative correlation, with UN, Cr, Ua, Cys positive correlation, and with serum Glu, CH, Tg, ApoB, LDL-CH level without significant correlation.In table 1.

The correlation of table 1 serum T HCY concentration and other indexs

	Folate	VB12	ApoA	HDL	Cr	Ua	Cys
								r	-0.460	-0.427	-0.135	-0.120	0.489	0.256	0.463
P	0.000	0.000	0.024	0.045	0.000	0.012	0.000

2 various disease group Serum Homocysteine Levels compare.The Serum Homocysteine Levels of various cardiovascular and cerebrovascular disease and diabetes group is apparently higher than control group, the highest with the level of cerebral infarction.In table 2.

The comparison of table 2 various disease Hcy

Tab2ComparisonofserumTHCYlevelsindifferent

groupsofpatients(-x±s)

**P＜0.01，vscontrolgroup

4, treat

44 diabetics are divided into 2 groups, often organize 22 patients.Treatment group: use salvia root leaf tea of the present invention, Fang Yong: red sage root leaf 20g, peach kernel 11g, hawthorn 10g, reticulate millettia 11g, mulberry leaf 10g, stir-baked FRUCTUS LEONURI 10g, FLOS CHRYSANTHEMI ALBA from Haizhou of China 11g, seed of feather cockscomb 10g, dried rhizome of rehmannia 10g, yncaria stem with hooks 10g, Ligusticum wallichii 11g, great burdock achene 10g, pseudo-ginseng 10g, dried orange peel 10g, root bark of tree peony 10g, root of Chinese trichosanthes 10g, make tea-drinking, every day 2 wraps, and rushes 500-1000ML warm water at every turn.It within one month, is a course for the treatment of.

Contrast groups: Metformin hydrochloride group.Should bring into use from low dose, according to the situation of patient, increase dosage gradually.The initial dose of usual metformin hydrochloride tablet is 0.5 gram, every twice-daily: or 0.85 gram, once a day: take with meal.Can increase weekly 0.5 gram, or every 2 weeks increase by 0.85 gram, add to every day 2 grams gradually, part vic.Adult's maximum recommended dosage is 2550 milligrams.Further control blood sugar patient to needing, dosage can add to each 0.85 gram of every day, and every day three times, medicine was preferably with breakfast, lunch and dinner part vic in order to better tolerance.Detect the serum folic acid of diabetic, vitamin B12 and Hcy level after one month, the prediction for arteriosclerotic complication is necessary.

Decocting liquid of the present invention is on the impact (-χ ± S) of patient's blood fat

5, discuss: in recent years, along with improving constantly of people's living standard, the disease incidence such as diabetes, coronary heart disease increases day by day.Chinese herbal medicine effect is stablized, few side effects, and research has the Chinese herbal medicine of softening blood vessel effect, can provide more method for clinical treatment diabetes, hyperlipidemia.The red sage root (SalviamiltiorrhizaBge.) is Labiatae (Labiatae) Salvia (Salvia) plant, is used as medicine with root.Current red sage root underground part and preparation thereof are widely used in clinical, but a large amount of aerial parts is given it up.There are some researches show, red sage root overground part contains the water soluble ingredient similar to root, and aerial part is about the heavy twice of root, therefore, very necessary to the exploitation of red sage root overground part, and salvia root leaf tea is exactly a kind of mode of exploitation red sage root leaf.The present invention carries out dynamic analysis to the active ingredient in red sage root leaf, and the red sage root leaf of to gather the highest period with chemical composition content for raw material, and controls the technological parameter of salvia root leaf tea process, to develop the high-quality salvia root leaf tea containing higher active ingredient.Carry out initial analysis to the drinking method of salvia root leaf tea and antioxygenic property thereof, the popularization for salvia root leaf tea provides technical support and theory support simultaneously.Result of study is as follows: (1) red sage root leaf moisture after August is substantially constant, and chlorophyll, carotenoid, soluble sugar, total phenol, flavonoids, vitamin C, tanshin polyphenolic acid B and Rosmarinic acid are in content peak period substantially in September to mid-October.Consider that the red sage root seals ridge in September, picking leaves does not only affect red sage root root growth during this period, is conducive to ventilation and penetrating light on the contrary; And after mid-October, red sage root leaf starts aging, various chemical composition content declines.Therefore, the suitable collection period of red sage root leaf is that September is to mid-October.(2) wither the flavonoids adding red sage root leaf, total phenol and free aminoacid content, but reduce the content of soluble sugar simultaneously, therefore to note the length of withering time, thus reach the active component both improving salvia root leaf tea, greatly can not affect again the organoleptic quality of salvia root leaf tea.This research finds that the most applicable withering time of red sage root leaf is about 6h.(3) by analyzing salvia root leaf tea fixing method, fresh leaf processing method to the impact of salvia root leaf tea chemical composition and organoleptic quality, show that the fresh leaf of the red sage root does not cut that to carry out steam beating effect best.(4) knead the broken cell rate that can increase salvia root leaf tea, thus its water extraction content is increased, be conducive to the brewing property improving salvia root leaf tea.(5) by analyzing the impact on salvia root leaf tea chemical composition and organoleptic quality of different dry drying method, show that the salvia root leaf tea quality of oven dry is better.(6) test is brewed to salvia root leaf tea, show that preferably brewing conditions is: brew water temperature 100 DEG C, brew tea-water proportion 1g: 50mL, brewing time 3-5min.Wherein brew water temperature to have the greatest impact to the water extraction of salvia root leaf tea and organoleptic quality.(7) water extract of salvia root leaf tea, red sage root leaf and red sage root tea and ethanol extract in hydroxyl radical free radical clearance rate, remove in DPPH free radical, reducing power and inhibition of peroxidation etc. and all have certain effect, and the oxidation resistance of salvia root leaf tea is higher than red sage root leaf and red sage root tea, show through being processed with the raising helping salvia root leaf tea oxidation resistance.

Claims

1. a red sage root leaf softening blood vessel health protection tea, it is characterized in that, described red sage root leaf softening blood vessel health protection tea comprises the raw material of following parts by weight: 10 ~ 50 parts, red sage root leaf, 10 ~ 20 parts, peach kernel, hawthorn 10 ~ 20 parts, reticulate millettia 10 ~ 20 parts, 10 ~ 20 parts, mulberry leaf, stir-baked FRUCTUS LEONURI 10 ~ 20 parts, FLOS CHRYSANTHEMI ALBA from Haizhou of China 10 ~ 20 parts, seed of feather cockscomb 10 ~ 20 parts, 10 ~ 20 parts, the dried rhizome of rehmannia, yncaria stem with hooks 10 ~ 20 parts, Ligusticum wallichii 10 ~ 20 parts, great burdock achene 10 ~ 20 parts, pseudo-ginseng 10 ~ 20 parts, dried orange peel 10 ~ 20 parts, the root bark of tree peony 10 ~ 20 parts, root of Chinese trichosanthes 10 ~ 20 parts.

2. red sage root leaf softening blood vessel health protection tea according to claim 1, it is characterized in that, in described red sage root leaf softening blood vessel health protection tea, the parts by weight of various raw material are: 10 ~ 50 parts, red sage root leaf, 10 ~ 15 parts, peach kernel, hawthorn 10 ~ 15 parts, reticulate millettia 10 ~ 15 parts, 10 ~ 15 parts, mulberry leaf, stir-baked FRUCTUS LEONURI 10 ~ 15 parts, FLOS CHRYSANTHEMI ALBA from Haizhou of China 10 ~ 15 parts, seed of feather cockscomb 10 ~ 15 parts, 10 ~ 20 parts, the dried rhizome of rehmannia, yncaria stem with hooks 10 ~ 20 parts, Ligusticum wallichii 10 ~ 20 parts, great burdock achene 10 ~ 20 parts, pseudo-ginseng 10 ~ 20 parts, dried orange peel 10 ~ 20 parts, the root bark of tree peony 10 ~ 20 parts, root of Chinese trichosanthes 10 ~ 20 parts.

3. red sage root leaf softening blood vessel health protection tea according to claim 1, it is characterized in that, the ratio of weight and number of various raw material in described red sage root leaf softening blood vessel health protection tea: 10 ~ 50 parts, red sage root leaf, 10 ~ 20 parts, peach kernel, hawthorn 10 ~ 20 parts, reticulate millettia 10 ~ 20 parts, 10 ~ 20 parts, mulberry leaf, stir-baked FRUCTUS LEONURI 10 ~ 20 parts, FLOS CHRYSANTHEMI ALBA from Haizhou of China 10 ~ 20 parts, seed of feather cockscomb 10 ~ 20 parts, 10 ~ 15 parts, the dried rhizome of rehmannia, yncaria stem with hooks 10 ~ 15 parts, Ligusticum wallichii 10 ~ 15 parts, great burdock achene 10 ~ 15 parts, pseudo-ginseng 10 ~ 15 parts, dried orange peel 10 ~ 15 parts, the root bark of tree peony 10 ~ 15 parts, root of Chinese trichosanthes 10 ~ 15 parts.

4. the preparation method of red sage root leaf softening blood vessel health protection tea as described in any one of claims 1 to 3 item, it is characterized in that, the preparation process of described red sage root leaf softening blood vessel health protection tea comprises following aspect:

A.9-10 red sage root leaf is plucked the middle of the month, frying;

B. the red sage root leaf fried is kneaded, Titian;

5. the preparation method of red sage root leaf softening blood vessel health protection tea according to claim 4, is characterized in that, in described step a, and the fresh and tender red sage root leaf of 9-10 picked by hand in the middle of the month, airing, parches; Red sage root leaf good for airing is put into the pot that completes and goes green grass or young crops, complete 20-30 minute at 70-100 DEG C, then puts into large iron pan and stir-fry, and on first backward downwards, firmly wants evenly, when red sage root leaf color starts jaundice, start little fire stir-fry 20-30 minute shaping.

6. the preparation method of red sage root leaf softening blood vessel health protection tea according to claim 4, it is characterized in that, in described step b, the red sage root leaf taking-up after completing is dried in the shade afterwards naturally, puts into large iron pan and knead, knead on first backward downwards, firmly want evenly, when filament leaf bar rope is comparatively tight, the baking machine turning in putting into 80-100 DEG C when becoming dark brown fry 30-45 minute shaping, then put into fragrance extracting machine Titian 20-30 minute, naturally dry after taking out.

7. the preparation method of red sage root leaf softening blood vessel health protection tea according to claim 4, it is characterized in that, in described step c, get other raw materials and clean impurity elimination, steep in the ethanol of 5-10 times amount, medicinal powder is equipped with in lid stainless steel cask, add 70% ethanol, quality is 0.8-1 times of meal, stirs, moistening airtight placement more than 1 hour, makes abundant expansion; Drug sample after moistening expansion is mixed pine by filter plate gauze bag parcel again bottom percolator after paving does loose, then powder is contained with stainless steel spoon, uniform loading percolator, dress 10-12 cm thick, even by T-bar pressure, then press aforesaid operations, loading in layer, suitable pressurization, medicinal powder must not load 2/3 eminence exceeding percolator; Medicinal powder face upper cover stainless steel orifice plate fastens, and opens the baiting valve below percolator, and puts a container, then slowly add 70% ethanol; Air between medicinal powder powder to be discharged, and have ethanol to flow out about about 20L, close baiting valve, cover cylinder of filtering, dipping 24 hours, then open baiting valve and carry out diacolation, control diacolation speed and be generally 1000g medicinal material outflow 2 ~ 3ml per minute, filtrate puts into liquid container, and pours ethanol time emptying into liquid container; Percolate is merged and leaves standstill.

8. the preparation method of red sage root leaf softening blood vessel health protection tea according to claim 4, it is characterized in that, in described steps d, filtrate above-mentioned steps obtained is inserted in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C, relative density is the concentrate of 1.05, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Refrigeration liquid is added the filter aid diatomite of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 0.1g crude drug amount; Paste after concentrated adds honey mediation and makes granule; Or convection drying makes pulvis.

9. the preparation method of red sage root leaf softening blood vessel health protection tea according to claim 4, is characterized in that, in described step e, mixed by the red sage root leaf made, pack after ultraviolet ray sterilization bactericidal with other raw materials of refinement.

10. the preparation method of a protecting and nourishing liver red sage root leaf health-care tea according to any one of claims 1 to 3, it is characterized in that, the preparation process of all the other raw materials can also be: get other raw materials clean dry, in 70 DEG C of baking ovens, dry 8-12h, taking-up is placed in cooling in drying box, pulverizes 80-100 mesh sieve with pulverizer; To be soaked the particle that sieves in water 12 hours, then put into extractor heating and boil 1 hour, filter, filtrate is for subsequent use; Filter residue adds water, and second time heating, boils 45 minutes, and filter, filtrate is for subsequent use; Filter residue adds water again, and half an hour is boiled in third time heating, filters, and heating is concentrated into paste, stand for standby use; Paste extract is placed in 70-90% ethanol and soaks 1-2 hour, in water-bath, be heated to 60 DEG C-70 DEG C, lixiviate 2h, every 10min stirs once, by filtered through gauze, add 50-60% ethanol in residue, 60 DEG C-70 DEG C are continued lixiviate 2h, every 10min stirs once, filtered through gauze, merges leaching liquor, is condensed into pasty state filtrate, insert in economic benefits and social benefits vacuum concentrator again, the paste after concentrated adds honey mediation and makes granule; Or convection drying makes pulvis.