CN105124078A - Gardenia blood-glucose-reducing and lipid-reducing healthcare tea and preparing method thereof - Google Patents
Gardenia blood-glucose-reducing and lipid-reducing healthcare tea and preparing method thereof Download PDFInfo
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Abstract
The invention provides gardenia blood-glucose-reducing and lipid-reducing healthcare tea. The gardenia blood-glucose-reducing and lipid-reducing healthcare tea is prepared from, by weight, 10-50 parts of gardenia, 10-20 parts of root of rehmannia, 10-20 parts of prunella vulgaris, 10-20 parts of eucommia ulmoides, 10-20 parts of angelica sinensis, 10-20 parts of astragalus membranaceus, 10-20 parts of rhizome sparganii, 10-20 parts of gynostemma pentaphylla, 10-20 parts of root bark of white mulberry, 10-20 parts of loofah sponge, 10-20 parts of dogwood, 10-20 parts of curcuma aromatica, 10-20 parts of Artemisia anomala, 10-20 parts of semen cassiae, 10-20 parts of bighead atractylodes rhizome, 10-20 parts of hawthorn, 10-20 parts of root bark of peony trees and 10-20 parts of glossy privet fruit. According to modern medical research, gardenia can cool the blood and expel toxins, clear away blood waste and promote metabolism of in vivo cells; the traditional Chinese medicine materials which can promote the blood circulation to remove blood stasis and have the obvious reducing effects on lipid and serum triglyceride are added, the traditional Chinese medicine materials are mostly light in taste and do not influence the fresh and gentle flower taste of the gardenia, and the healthcare tea can be easily accepted by people and can well achieve the effects of reducing lipid and blood glucose.
Description
Technical field
The present invention relates to the hypoglycemic health products containing deriving from plant composition, particularly a kind of gardenia hypoglycemic health protection tea and preparation method thereof.
Background technology
Along with industrialized development, the change of dietary structure, the improvement of living condition, the quantity of Overweight and obesity crowd worldwide increases rapidly, and in the trend of becoming younger, become global and have a strong impact on healthy epidemic disease, therefore, search of health effective hypoglycemic method has very real significance, and antihypelipidemic active substance is the key that people expect to solve problem of obesity always safely and effectively.Medical research also shows, Chinese medicine great burdock achene can affect HypercholesterolemicRats, significantly can reduce the cholesterol in serum and liver.There is reducing blood lipid, antibacterial, hypoglycemic, antioxidation, and energy interference body is to the absorption of fat, promotes that the fat taken in excretes.
Hypoglycemic method is a lot, there are dietetic treatment, kinesiatrics, medicinal treatment and clinical treatment etc. these methods more or less have weak point, what have also easily causes side effect, as diarrhoea, apocleisis etc. and health treatment hypoglycemic has easy to use, have no side effect, the features such as effect is remarkable, and extremely consumers.
The high speed development of Modern Urban Living, also brings a series of rich man's disease.Wherein " three is high " and obesity are the primary enemies of puzzlement people." three high diseases " refers to hypertension, hyperglycaemia (diabetes) and hyperlipemia.Usually along with obesity.They be modern society derive from " rich man's disease ", possible individualism, also may be interrelated.As: diabetes patient is easy to suffer from hypertension or hyperlipemia simultaneously, and high fat of blood is the principal element of artery sclerosis formation and development, and arteriosclerotic's blood vessel elasticity difference aggravation blood pressure raises, so the later stage all defines " three high diseases ".Be what has statistics about three height, in the Chinese ten large causes of death, the death rate relevant to metabolic disease is just up to 35.7%, and the death toll relevant to " three is high " also accounts for 27% of total death toll.High fat of blood can cause blood vessel embolism; Hypertension can cause cerebral hemorrhage and rupture of blood vessel in brain; Hyperglycaemia can cause diabetes.The World Health Organization once clearly proposed, and prevented the first line of defence of cardiovascular disease from reducing " three is high " exactly and controlling " three is high ".A lot of diabetes patient is with hyperlipidemia, and therefore diabetes and hyperlipidemia, people call that sister is sick usually, and think that high fat of blood is the secondary disease of diabetes.The diabetic of about 40% has disorders of lipid metabolism according to statistics.Be characterized in that triglycerides increases to reduce with HDL.When the reason that diabetes cause blood fat to increase is due to diabetes patient's insufficient insulin, body lactonase activity lowers, and therefore easily blood fat increases.Diabetes itself also accompany fat, protein and water, dielectric disorder except carbohydrate metabolism disturbance simultaneously on the other hand.Often there is free fatty to mobilize out from fat depot, triglycerides and FFA concentrations in blood are increased.Diabetes B people takes food too much on the one hand again, and motion is few, and impel lipid synthesis in body to increase, this is also the reason causing blood fat to increase.And fat companion's high fat of blood person, because insulin receptor number reduces relatively, thus produce insulin resistance, easy induced Diabetic.Blood fat increased perosn also easily causes the heart, cerebrovascular complication.
Cape jasmine property is bitter, cold, nontoxic; Gas is micro-, the micro-acid of taste and bitter; Enter the heart, liver, lung, stomach warp.Gardenia is containing flavonoids gardenin, pectin, tannin, crocin etc., and root, leaf, Hua Jieke are used as medicine, and have calmness, step-down, antibacterial, cause rush down, ease pain, anti-inflammatory, regulate smooth muscle, accelerate the effects such as the healing of soft tissue, have purging intense heat relieving restlessness, anti-inflammatory is dispelled heat, reducing fever and causing diuresis, effect of removing pattogenic heat from the blood and toxic material from the body.
Gardenia bitter cold, can blood system and clear heat symptoms caused by an exopathgen, and wide intestines defaecation, anti-cancer, gardenia contains cellulose, can prevent the outbreak of hemorrhoid and the generation of carcinoma of the rectum knurl.Cape jasmine root, leaf, fruit all can be used as medicine, and have purging intense heat relieving restlessness, and anti-inflammatory is dispelled effect of heat, reducing fever and causing diuresis, removing pattogenic heat from the blood and toxic material from the body.
Gardenia, fruit, leaf and Gen Ke are used as medicine, and generally make tea or decoct soup clothes.Cape jasmine containing gardenoside, geniposide, Chinese Fevervine Herb time glucoside methyl esters and a small amount of shanzhiside, have reducing fever and causing diuresis, removing pattogenic heat from the blood and toxic material from the body, jaundice, blood drench that pain is puckery, the red and swollen pain of order, fiery carbuncle, the effect such as hypotensive.Wherein cape jasmine fruit is used as medicine, and cures mainly pyreticosis high fever, dysphoria and insomnia, and excess fire is had a toothache, aphthae, and nose is advised, and spits blood, eye conjunctivitis, sore swollen toxin, icteric catarrhal jaundice, favism, hematuria; Traumatism and bleeding, bruise are controlled in external application.Root is used as medicine and cures mainly catarrhal jaundice, traumatic injury, acute toothache.
Compendium of Material Medica claims it, and " happy color, it is used by " a thousand pieces of gold wing " face cream." " the southern regions of the Yunnan Province book on Chinese herbal medicine " claim its " purte the white, only cough with lung heat, only nosebleed epistaxis blood, dissolving phlegm." meridian distribution of property and flavor: cold in nature, sweet-bitter flavor; Enter lung, Liver Channel.Effect: removing heat from the lung to relieve cough, cooling blood and hemostasis.Cure mainly cough with lung heat, nose, cough up phlegm, the illnesss such as pyogenic infections.Main component: gardenia contains Triterpenoid, gardenia acid A, B and son acid.Containing volatile oil, comprise benzyl acetate, bergamio, another containing pigment glucoside, C6H14O6 etc.In addition, also containing carbohydrate, protein, crude fibre and multivitamin.
Gardenia is containing compositions such as benzyl acetate, bergamio, ethyl ester styracins.Adopt extraction can produce gardenia concrete yield of extract 0.1-0.13% with gardenia and can be widely used in cosmetic perfumes and food flavor.Steam distillation is adopted to produce gardenia flower oil.Oil yield about 0.02%.Gardenia flower oil can prepare multiple floral type perfume, perfumed soap, cosmetic essence.In addition can by vacuum fractionation method using the benzyl acetate of gardenia flower oil and bergamio is isolated out commonly uses type-odor as daily cosmetic or blender is also usually used in the essence of food as chewing gum.
Present various hypoglycemic health products, medicine spreads unchecked, but great majority are had a good apperance only, false propaganda on a grand scale, probably without any health care, but causes the huge injury of the person, therefore, search of health effective hypoglycemic method has very real significance.Antihypelipidemic active substance is the key that people expect to solve problem of obesity always safely and effectively.Chinese medicine hypoglycemic, having advantage that is nontoxic, that can be absorbed completely by organism, is the Main way that we study.There are reducing blood lipid, antibacterial, hypoglycemic, antioxidation in present market in the urgent need to developing one, and energy interference body is to the absorption of fat, promote the hypoglycemic product that the fat taken in excretes, and there are health products that are nontoxic, that can be absorbed completely by organism.
Summary of the invention
Technical problem to be solved by this invention is, dragons and fishes jumbled together for most of antihypelipidemic products in present market, false propaganda, probably without any health care, but cause the huge injury of the person, therefore, search of health effective hypoglycemic method has very real significance, and hypoglycemic active material is the key that people expect the high problem of solution three always safely and effectively.Modern medicine study, the cool blood toxin expelling of gardenia, can reduce serum total cholesterol and triacylglycerol content, promotes the propagation of cells in vivo, strengthening and enhancing white blood cell, and " blood platelet ", makes T cell with the speed increment of 3 times, reinforced immunological power, promote anticancer effect; Impel phosphorus calcium and the balance of vitamin D in combination in body, maintain human body and grow up; Blood rubbish can be cleared up, impel the metabolism of cells in vivo; Add some promoting blood circulation and removing blood stasis, fat and serum triglyceride are all had to the Chinese medicine of obvious reducing effect, and can microcirculation be improved, the most mouthfeel of these medicinal materials is light, do not affect the taste of the light delicate fragrance of gardenia tea, make people be easy to accept, more can reach effect of blood lipid-reducing blood sugar-decreasing preferably.
For solving above-mentioned technical barrier, the invention provides a kind of gardenia hypoglycemic health protection tea, described in it, gardenia hypoglycemic health protection tea comprises the raw material of following parts by weight: gardenia 10 ~ 50 parts, 10 ~ 20 parts, the dried rhizome of rehmannia, selfheal 10 ~ 20 parts, the bark of eucommia 10 ~ 20 parts, Radix Angelicae Sinensis 10 ~ 20 parts, the Radix Astragali 10 ~ 20 parts, Rhizoma Sparganii 10 ~ 20 parts, gynostemma pentaphylla 10 ~ 20 parts, the root bark of white mulberry 10 ~ 20 parts, luffa 10 ~ 20 parts, Fructus Corni 10 ~ 20 parts, root tuber of aromatic turmeric 10 ~ 20 parts, Artemisia anomala 10 ~ 20 parts, cassia seed 10 ~ 20 parts, the bighead atractylodes rhizome 10 ~ 20 parts, hawthorn 10 ~ 20 parts, the root bark of tree peony 10 ~ 20 parts, the fruit of glossy privet 10 ~ 20 parts.
Described gardenia hypoglycemic health protection tea, in gardenia hypoglycemic health protection tea described in it, the parts by weight of various raw material can be: gardenia 10 ~ 40 parts, 10 ~ 15 parts, the dried rhizome of rehmannia, selfheal 10 ~ 15 parts, the bark of eucommia 10 ~ 15 parts, Radix Angelicae Sinensis 10 ~ 15 parts, the Radix Astragali 10 ~ 15 parts, Rhizoma Sparganii 10 ~ 15 parts, gynostemma pentaphylla 10 ~ 15 parts, the root bark of white mulberry 10 ~ 15 parts, luffa 10 ~ 20 parts, Fructus Corni 10 ~ 20 parts, root tuber of aromatic turmeric 10 ~ 20 parts, Artemisia anomala 10 ~ 20 parts, cassia seed 10 ~ 20 parts, the bighead atractylodes rhizome 10 ~ 20 parts, hawthorn 10 ~ 20 parts, the root bark of tree peony 10 ~ 20 parts, the fruit of glossy privet 10 ~ 20 parts.
Described gardenia hypoglycemic health protection tea, in gardenia hypoglycemic health protection tea described in it, the parts by weight of various raw material can also be: gardenia 10 ~ 30 parts, 10 ~ 20 parts, the dried rhizome of rehmannia, selfheal 10 ~ 20 parts, the bark of eucommia 10 ~ 20 parts, Radix Angelicae Sinensis 10 ~ 20 parts, the Radix Astragali 10 ~ 20 parts, Rhizoma Sparganii 10 ~ 20 parts, gynostemma pentaphylla 10 ~ 20 parts, the root bark of white mulberry 10 ~ 20 parts, luffa 10 ~ 15 parts, Fructus Corni 10 ~ 15 parts, root tuber of aromatic turmeric 10 ~ 15 parts, Artemisia anomala 10 ~ 15 parts, cassia seed 10 ~ 15 parts, the bighead atractylodes rhizome 10 ~ 15 parts, hawthorn 10 ~ 15 parts, the root bark of tree peony 10 ~ 15 parts, the fruit of glossy privet 10 ~ 15 parts.
For solving the problems of the technologies described above, the present invention also provides the preparation method of a kind of gardenia hypoglycemic health protection tea, and described in it, the preparation process of gardenia hypoglycemic health protection tea comprises following aspect:
A. the preparation of gardenia, becomes component 1;
B. by concentration of liquid medicine that all the other raw materials extract; Become component 2;
D. component 1, component 2 are mixed, after concentrated granulation, sterilizing, tea-drinking is worked as in pack.
In described step a, can get the gardenia obtained and clean, the airing time, at 7-12 hour, parches; Described gardenia is put into 5-10 times amount ethanol, soak 1-2 hour, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extract, 100-120 order filters, and is merged by No. 2 extracts and leaves standstill, decompression recycling ethanol, and to be concentrated into liquor strength be 0.6g crude drug/mL, after suction filtration, when the relative density of filtrate is about 20 DEG C 1.08; Be decompressed to 0.03-0.08MPa, temperature remains on 60-80 DEG C, and being concentrated into relative density is 1.20, and the medicinal extract of temperature to 60 DEG C-70 DEG C, as component 1.
In described step b, surplus stock can be cleaned impurity elimination, dry, be ground into particle, soak 1 hour; Soaked raw material is put boiling secondary in multi-function extractor; Add up the water of medicinal material 10 times amount for the first time, decoct 1.5 ~ 2 hours, get decocting liquid, filter; Second time adds the water of total amount 7 times amount, decocts 1 ~ 1.2 hour, and get twice decocting liquid mixing, filtration, being concentrated into relative density is 1.20, and the medicinal extract of temperature to 60 DEG C-70 DEG C, as component 2.
In described step c, by also 2-in-1 to component 1 and component, can insert in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C, relative density is the concentrate of 1.25, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Will refrigeration liquid add 0.3% filter aid diatomite, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 0.1g crude drug amount, and then add dextrin and put into granulator and granulate, ultraviolet disinfection, packs and get final product.
For solving the problems of the technologies described above, the present invention reoffers the preparation method of a kind of gardenia hypoglycemic health protection tea, and its preparation process can also be:
A. the preparation of gardenia, as component 1;
B. all the other bulk drugs described added alcohol immersion, extract 3 times as component 2;
C. component 1 and component 2 are mixed, add appropriate propolis after concentrated and be in harmonious proportion, bottle after ultraviolet ray sterilization bactericidal.
In described step a, the gardenia of clean airing can be put in 10 times amount ethanol, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extract, 100-120 order filters, then is the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, when ultrafiltrate reduced pressure concentration relative density is 80 DEG C 1.06 medicinal extract, heating is concentrated into paste, stand for standby use, becomes component 1.
In described step b, all the other raw materials described can be put into 5-10 times amount ethanol, soak 1-2 hour, heating extraction 2 times, each 1-2 hour, removes supernatant, merges extract, 100-120 order filters, No. 2 extracts are merged and leaves standstill, decompression recycling ethanol, and to be concentrated into liquor strength be 0.6g crude drug/mL, after suction filtration, when the relative density of filtrate is about 20 DEG C 1.08; Be decompressed to 0.03-0.08MPa, temperature remains on 60-80 DEG C, and being concentrated into relative density is 1.20, and the medicinal extract of temperature to 60 DEG C-70 DEG C, as component 2.
The present invention purifies the blood toxin expelling, and enriching yin and nourishing kidney, can clear up blood rubbish, impel the metabolism of cells in vivo; Add some promoting blood circulation and removing blood stasis, fat and serum triglyceride are all had to the Chinese medicine of obvious reducing effect, and can microcirculation be improved, the most mouthfeel of these medicinal materials is light, do not affect the taste that gardenia tea delicate fragrance is quiet and tastefully laid out, make people be easy to accept, more can reach effect of blood lipid-reducing blood sugar-decreasing preferably.
Detailed description of the invention
Hypoglycemic method is a lot, there are dietetic treatment, kinesiatrics, medicinal treatment and clinical treatment etc. these methods more or less have weak point, what have also easily causes side effect, as diarrhoea, apocleisis etc. and health treatment hypoglycemic has easy to use, have no side effect, the features such as effect is remarkable, and extremely consumers.
The high speed development of Modern Urban Living, also brings a series of rich man's disease.Wherein " three is high " and obesity are the primary enemies of puzzlement people." three high diseases " refers to hypertension, hyperglycaemia (diabetes) and hyperlipemia.Usually along with obesity.They be modern society derive from " rich man's disease ", possible individualism, also may be interrelated.As: diabetes patient is easy to suffer from hypertension or hyperlipemia simultaneously, and high fat of blood is the principal element of artery sclerosis formation and development, and arteriosclerotic's blood vessel elasticity difference aggravation blood pressure raises, so the later stage all defines " three high diseases ".Be what has statistics about three height, in the Chinese ten large causes of death, the death rate relevant to metabolic disease is just up to 35.7%, and the death toll relevant to " three is high " also accounts for 27% of total death toll.High fat of blood can cause blood vessel embolism; Hypertension can cause cerebral hemorrhage and rupture of blood vessel in brain; Hyperglycaemia can cause diabetes.The World Health Organization once clearly proposed, and prevented the first line of defence of cardiovascular disease from reducing " three is high " exactly and controlling " three is high ".A lot of diabetes patient is with hyperlipidemia, and therefore diabetes and hyperlipidemia, people call that sister is sick usually, and think that high fat of blood is the secondary disease of diabetes.The diabetic of about 40% has disorders of lipid metabolism according to statistics.Be characterized in that triglycerides increases to reduce with HDL.When the reason that diabetes cause blood fat to increase is due to diabetes patient's insufficient insulin, body lactonase activity lowers, and therefore easily blood fat increases.Diabetes itself also accompany fat, protein and water, dielectric disorder except carbohydrate metabolism disturbance simultaneously on the other hand.Often there is free fatty to mobilize out from fat depot, triglycerides and FFA concentrations in blood are increased.Diabetes B people takes food too much on the one hand again, and motion is few, and impel lipid synthesis in body to increase, this is also the reason causing blood fat to increase.And fat companion's high fat of blood person, because insulin receptor number reduces relatively, thus produce insulin resistance, easy induced Diabetic.Blood fat increased perosn also easily causes the heart, cerebrovascular complication.
Cape jasmine property is bitter, cold, nontoxic; Gas is micro-, the micro-acid of taste and bitter; Enter the heart, liver, lung, stomach warp.Gardenia is containing flavonoids gardenin, pectin, tannin, crocin etc., and root, leaf, Hua Jieke are used as medicine, and have calmness, step-down, antibacterial, cause rush down, ease pain, anti-inflammatory, regulate smooth muscle, accelerate the effects such as the healing of soft tissue, have purging intense heat relieving restlessness, anti-inflammatory is dispelled heat, reducing fever and causing diuresis, effect of removing pattogenic heat from the blood and toxic material from the body.
Gardenia bitter cold, can blood system and clear heat symptoms caused by an exopathgen, and wide intestines defaecation, anti-cancer, gardenia contains cellulose, can prevent the outbreak of hemorrhoid and the generation of carcinoma of the rectum knurl.Cape jasmine root, leaf, fruit all can be used as medicine, and have purging intense heat relieving restlessness, and anti-inflammatory is dispelled effect of heat, reducing fever and causing diuresis, removing pattogenic heat from the blood and toxic material from the body.
Gardenia, fruit, leaf and Gen Ke are used as medicine, and generally make tea or decoct soup clothes.Cape jasmine containing gardenoside, geniposide, Chinese Fevervine Herb time glucoside methyl esters and a small amount of shanzhiside, have reducing fever and causing diuresis, removing pattogenic heat from the blood and toxic material from the body, jaundice, blood drench that pain is puckery, the red and swollen pain of order, fiery carbuncle, the effect such as hypotensive.Wherein cape jasmine fruit is used as medicine, and cures mainly pyreticosis high fever, dysphoria and insomnia, and excess fire is had a toothache, aphthae, and nose is advised, and spits blood, eye conjunctivitis, sore swollen toxin, icteric catarrhal jaundice, favism, hematuria; Traumatism and bleeding, bruise are controlled in external application.Root is used as medicine and cures mainly catarrhal jaundice, traumatic injury, acute toothache.
Compendium of Material Medica claims it, and " happy color, it is used by " a thousand pieces of gold wing " face cream." " the southern regions of the Yunnan Province book on Chinese herbal medicine " claim its " purte the white, only cough with lung heat, only nosebleed epistaxis blood, dissolving phlegm." meridian distribution of property and flavor: cold in nature, sweet-bitter flavor; Enter lung, Liver Channel.Effect: removing heat from the lung to relieve cough, cooling blood and hemostasis.Cure mainly cough with lung heat, nose, cough up phlegm, the illnesss such as pyogenic infections.Main component: gardenia contains Triterpenoid, gardenia acid A, B and son acid.Containing volatile oil, comprise benzyl acetate, bergamio, another containing pigment glucoside, C6H14O6 etc.In addition, also containing carbohydrate, protein, crude fibre and multivitamin.
Gardenia is containing compositions such as benzyl acetate, bergamio, ethyl ester styracins.Adopt extraction can produce gardenia concrete yield of extract 0.1-0.13% with gardenia and can be widely used in cosmetic perfumes and food flavor.Steam distillation is adopted to produce gardenia flower oil.Oil yield about 0.02%.Gardenia flower oil can prepare multiple floral type perfume, perfumed soap, cosmetic essence.In addition can by vacuum fractionation method using the benzyl acetate of gardenia flower oil and bergamio is isolated out commonly uses type-odor as daily cosmetic or blender is also usually used in the essence of food as chewing gum.
Bark of eucommia free amino acid is few, a small amount of protein contained, be with most foodstuff like adequate proteins, namely can be hydrolyzed 8 seed amino acids detected needed by human.Determine 15 kinds of mineral elements contained by the bark of eucommia, wherein have the trace elements such as zinc, copper, iron, and the macroelement such as calcium, phosphorus, potassium, magnesium.The medicinal bark of eucommia, is the dry bark of the Eucommiaceae plant bark of eucommia, is Chinese famous and precious tonic herb.Its taste is sweet, warm in nature.Have tonify the liver and kidney, strengthen muscles and bones, coordinating Chong and Conception Vessels, solid through antiabortive effect.Can treat the pain in waist and lower extremities or aching and limp unable that kidney-yang deficiency causes, born of the same parents' tire that liver-qi invasion causes is solid, and scrotum is wet the disease such as to itch.Be listed in top grade in Shennong's Herbal.The modern study bark of eucommia has rubbish in purged body, strengthens human body cell metabolism, prevents muscle skeleton aging, balanced human's blood pressure, decomposer inner cholesterol, reduces body fat, recovers blood vessel elasticity, diuresis heat-clearing, broad-spectrum antiseptic, stimulating central nervous system, improves white blood cell pharmacological action.
The dried rhizome of rehmannia: the dried rhizome of rehmannia is also radix rehmanniae recen, the fresh or dry block root of Scrophulariaceae herbaceos perennial glutinous rehmannia RehmanniaglutinosaLibosch..Heat-clearing, promote the production of body fluid, moisturize, laxation, the broken stasis of blood, raw new, pain relieving, menstruation regulating, the metal-inflicted wound stasis of blood, cool blood, hemostasis; The effect of fresh rehmannia root and radix rehmanniae recen is different.Fresh rehmannia root clearing heat and promoting fluid, can stop blooding and cool blood, be often for consumption of YIN caused by febrile disease, the illnesss such as haematemesis, abscess of throat, the deep red polydipsia of tongue, a spot dermexanthesis and nosebleed heat.Relative to fresh rehmannia root, radix rehmanniae recen is heat clearing and blood cooling, also can promote the production of body fluid, all right yin-nourishing, is used for treatment yin asthenia generating intrinsic heat, hectic fever due to yin labor heat, the deep red polydipsia of tongue, sends out the problems such as spot dermexanthesis.The dried rhizome of rehmannia is cold in nature, and function is enriching yin and nourishing kidney.Not only promote the production of body fluid to quench thirst and heat clearing and blood cooling, also have effect to metrorrhagia, irregular menstruation, fetal irritability, constipation etc., every blood system has the people of thermal burn the moon, can often take.If want to treat warm heat disease, qingying decoction can be done with the dried rhizome of rehmannia; If the later stage for the treatment of warm disease, because waste heat does not also disappear to the greatest extent, the dried rhizome of rehmannia should be used for boiling Qinghao Biejia Tang; In addition, contain for blood-head poison, macula purple is black, and the serious heat of warm heat disease enters the symptom of ying blood, can take the Sisheng Wan that the dried rhizome of rehmannia is made; General want nourishing Yin and promoting production of body fluid to treat interior heat quenches one's thirst with constipation, the once liquid soup that the dried rhizome of rehmannia boils should be eaten.
Selfheal is the dry fruit ear of labiate selfheal PrunellavulgarisL..All parts of the country are all produced, main product in Jiangsu, Zhejiang, Anhui, the ground such as Henan.Gather when summer, fruit ear was brownish red, removing impurity, dries.Raw use.The property of medicine is pungent, bitter, cold.Return liver, gallbladder channel.Effect clearing heat-fire, improving eyesight, mass dissipating and swelling eliminating.Shennong's Herbal: " main fever and chills, scrofula, mouse fistula, head sore, broken disease.Loose goitre knot gas, pin swells arthritis with fixed pain caused by dampness." Compendium of Material Medica: " selfheal controls order pain, and with granulated sugar water logging one ight, get it and can separate interior heat, slow irascibility is also.Lou Quan is apt to cloud, selfheal control order pearl pain to night then notably, the magical effect, or with bitter cold snack made with traditional Chinese medicines instead notably, the also magical effect.Lid order pearl connects order originally, and liver system also, belongs to the warp of the moon of fainting.Night very and some bitter and cold medicines anti-notably, night is with cold also cloudy therefore also.The gas of the pure sun of summer withered official report, mends cloudy blood vessels of fainting, therefore controls this as god, with Yang Zhiyin also.”
The order that the fruit of glossy privet is used for the deficiency of liver-yin and kidney-yin is secretly failed to understand, hypopsia, poliosis, soreness of waist tinnitus and fever due to yin deficiency etc.This product energy tonifying liver kidney yin, but the efficacy of a drug is gentle, slowly must get effect.Control order secretly to fail to understand, often join cultivated land, root tuber of aromatic turmeric is equal to use, controls poliosis, and often join the same use of mulberries, fever due to yin deficiency, often joins the fruit of Chinese magnoliavine.The deficiency of liver-yin and kidney-yin, Light-headedness, seminal emission tinnitus, soreness and weakness of waist and knees, poliosis, coronary heart disease, hyperlipidemia, hypertension, chronic hepatitis.The protective effect research of liver is thought, the fruit of glossy privet contains oleanolic acid, to rat skin lower injection, serum glutamic pyruvic transminase can be reduced, there is obvious protective effect to the hepatic injury of Carbon Tetrachloride Induced, and can liver cell regeneration be promoted. oleanolic acid also can make triglycerides accumulation minimizing in liver, degeneration of liver cells necrosis obviously alleviates, glycogen accumulation increases, serum γglobulin declines; Ultra microstructure visible liver cell mitochondrial swelling and endosomal vesicle sex change alleviate, hepatic tissue interstitial inflammation habituation.
Rhizoma Sparganii returns liver, the spleen channel.There is broken blood gas, the effect of the long-pending pain relieving that disappears.For abdominal mass lump in the abdomen, dysmenorrhoea, hemostasis through closing, chest impediment and cardialgia, dyspepsia distending pain.Compendium of Material Medica: logical Liver Channel hematocele, woman's moon water, postpartum extravesated blood." opening treasured ": old addiction abdominal mass, gathers caking, and postpartum, extravesated blood blood was tied, Tong Yueshui, induced abortion, pain relieving profit gas.
Luffa is cool in nature, and taste is sweet.Enter lung, stomach, Liver Channel.Dredging collateral, invigorates blood circulation, and dispels the wind.For the contraction of numbness pain, distending pain in the chest and hypochondrium, alactation." book on Chinese herbal medicine is just read ": luffa, enters channels and collaterals, separates heat symptoms caused by an exopathgen.Heat is removed then wind and is gone, and in network, the unlikely knot of body fluid is combined into phlegm, becomes all diseases of pyogenic infections, therefore cloud removing toxic substances ear.
Hawthorn is containing multivitamin, crataegolic acid, tartaric acid, citric acid, malic acid etc., and also containing the mineral matter such as flavonoids, lactone, carbohydrate, protein, fat and calcium, phosphorus, iron, contained lipolytic enzyme can promote the digestion of fat food.Promote gastric secretion and increase the functions such as stomach endoenzyme element.The traditional Chinese medical science is thought, hawthorn has the effects such as long-pendingization that disappear is stagnant, convergence stops dysentery, activate blood circulation and disperse blood clots.Cure mainly the diseases such as eating accumulation, chest diaphragm ruffian are full, the amenorrhoea of hernia blood stasis.Containing the drug ingedient such as mountain terpene and brass class in hawthorn, there is significant hemangiectasis and hypotensive effect, there is the function strengthening cardiac muscle, arrhythmia, adjusting blood lipid and cholesterol level, hawthorn has the effect activated blood circulation and dispersed blood clots, contribute to removing local extravasated blood state, have auxiliary curative effect to traumatic injury; Flavonoids contained by hawthorn and the substance such as vitamin C, carrotene block and reduce the generation of free radical, can strengthen the immunity of body, have anti-aging, anticancer effect; Having in hawthorn relievings asthma reduces phlegm, the composition of anti-bacteria, treatment abdominal pain diarrhea.
The root bark of tree peony, has another name called moutan bark, Chinese medicine name.For the dry root skin of ranunculaceae peony.Originate in the ground such as Anhui, Shandong.Autumn excavates root, and removing radicula, strips root skin, dry.Life is used or is fried and uses.Compendium of Material Medica: " nourishing Yin and falling fire, separate spot poison, throat, diuresis stasis.Descendant specially controls fire mutually with yellow tiller, does not know that the merit of the root bark of tree peony more wins also.Red colored person's profit, the person of spending in vain mends, and people also seldom realizes, and should distinguish it." modern study, contained paeonol and glucosides constituents in addition thereof all have antiinflammatory action; The methanolic extract of moutan bark has suppression Platelet; Paeonol has the effects such as central inhibitory action and antiatherosclerosis, diuresis, antiulcer such as calmness, cooling, antipyretic, analgesia, spasmolysis.
Gynostemma pentaphylla finds through modern medicine study, gynostemma pentaphylla principle active component is polysaccharide, flavonoids, saponins and microelement kind, its effect mainly promotes body fat class metabolism, nutrition human body cell, there is good detoxicating, relieving inflammation effect simultaneously, be widely used in high fat of blood, fatty liver, obesity, constipation, insomnia, hepatitis B, the treatment of chronic airway inflammation (sphagitis, enterogastritis etc.) and health care.
Poria cocos taste is sweet, light, property is put down, and is used as medicine and has the function of clearing damp and promoting diuresis, beneficial spleen and stomach, antitoxic heart-soothing and sedative.Modern medicine study: Poria cocos energy enhanced machine body immunity function, pachymaran has significantly antitumor and protect the liver dirty effect.Poria cocos slightly sweet flavor is put down, and enters the heart, lung, the spleen channel.There is eliminating dampness and diuresis, strengthening the spleen and stomach, effect of antitoxic heart-soothing and sedative.Can control difficult urination, oedema turgor, phlegm and retained fluid is coughed inverse, vomits inverse, and vomiting during early pregnancy, has loose bowels, seminal emission, stranguria with turbid discharge, palpitation with fear, forgetful disease such as grade.The Li Shui of Poria cocos, is reached by strong fortune spleen PFT, different from the Chinese medicine of other direct Li Shui.For splenasthenic diarrhea, the lower Poria cocos of band can invigorating the spleen, again can excreting dampness, and for having loose bowels caused by insufficiency of the spleen dysfunction of the spleen in transportation and transformation, being with down, application Poria cocos has the effect of giving consideration to both the incidental and fundamental, the compatibilities such as normal and Radix Codonopsis, the bighead atractylodes rhizome, Chinese yam.Can be used as tonifying lung spleen, control the adjuvant of the deficiency of vital energy.
The red sage root is bitter, is slightly cold.The thoughts of returning home, Liver Channel.Stasis-dispelling and pain-killing, activating blood to promote menstruation, clear away heart-fire relieving restlessness.For irregular menstruation, through closing dysmenorrhoea, a lump in the abdomen causing distension and pain, and chest ventral spine pain, hot numbness pain, sore swells and ache, dysphoria and insomnia.For sternal rib hypochondriac pain, arthralgia due to wind-dampness, abdominal mass lumps, and sore swells and ache, fall fall forward grieved, irregular menstruation, through closing dysmenorrhoea, postpartum stasis of blood pain etc.Treatment sternal rib pain, abdominal mass caking, and irregular menstruation, through amenorrhoea pain, there is good effect." detailed outline " carries: the red sage root, and by " the sensible opinion of married woman " cloud, gynecopathy controlled by Siwu Tang, pays no attention to antenatal postpartum, how many through water, all can be general, and the only taste red sage root falls apart, and cures mainly identical with it.The lid red sage root can break place blood, mends new blood, peaceful tire, and fall stillborn foetus, only metrorrhagia stagnant under, menstruation regulating arteries and veins.Main Compositions of Radix Salviae Miltiorrhizae tanshinone has hemangiectasis, improves circulation, removes the effects such as intravascular coagulation, has effect of invigorating blood circulation trace, and can promote that liver blood circulates, be beneficial to liver cell regeneration.
Root tuber of aromatic turmeric is pungent, bitter, cold.Return liver, the heart, lung channel.Function cures mainly regulating qi to disperse stagnation, heart fire-clearing upset-relieving, normalizing gallbladder to cure jaundice.For through closing dysmenorrhoea, chest and abdomen swelling and pain, shouting pain, pyreticosis coma, epilepsy is gone mad, and jaundice urine is red.Promoting qi circulation and removing obstruction in the collateral, cool blood breaks the stasis of blood.Control all pains of chest abdomen side of body rib, lose the heart demented, pyreticosis coma, spit blood, bleeding from five sense organs or subcutaneous tissue, hematuria, blood drenches, women's vicarious menstruation, jaundice." property of medicine opinion " carries it: control woman place vim and vigour pained, and cold air knot is poly-, and warm vinegar rubs and takes it.Tang Materia Medica carries it: main blood amasss, lower gas, myogenic, hemostasis, and broken extravesated blood, blood drenches, hematuria, metal-inflicted wound.
The Radix Astragali has the effects such as invigorating qi for strengthening superficies, sharp water detumescence, pus draining and toxin expelling, myogenic.The history of medicinal existing more than 2000 year so far of the Radix Astragali, modern study, the Radix Astragali is containing the various trace elements such as saponin, sucrose, polysaccharide, several amino acids, folic acid and selenium, zinc, copper.Have enhanced machine body immunity function, protect the liver, diuresis, anti-ageing, resisting stress, step-down and antibacterial action more widely.But table is real evil to be contained, retention of dampness due to stagnation of QI, and dyspepsia is stagnated, ulcer from the beginning of or the real example such as routed after heat poison Shang Sheng.The Radix Astragali has invigorating qi for strengthening superficies, diuresis holder poison, apocenosis, effect of expelling pus and promoting granulation.Weak for the deficiency of vital energy, anorexia and loose stool, the sinking of qi of middle-jiao, rushes down prolapse of the anus for a long time, uterine bleeding of having blood in stool, exterior deficiency spontaneous perspiration, and ulcer difficulty is burst, and burst for a long time and do not hold back, the deficiency of blood is sallow, and interior heat is quenched one's thirst." herbal classic " is recorded: " main ulcer, loses sore for a long time, apocenosis pain relieving.Qi-restoratives, children's's all kinds of diseases and ailments." " Japan hanako materia medica " record: " help gas to strengthen the bone, put on flesh and enrich blood.”
The root bark of white mulberry is the root skin of moraceae plants mulberry MorusalbaL..Main product in Anhui, Henan, Zhejiang, Jiangsu, the ground such as Hunan.Effect: removing heat from lung and relieving asthma, inducing diuresis for removing edema.Cough for lung heat and breathe heavily, the edema of the face, the diseases such as difficult urination." property of medicine opinion ": make, flat.Can control lung qi breathes heavily full, aqueous vapor edema, and main wound is exhausted, dredging water passages, and disappear aqueous vapor, the headache of consumptive disease visitor heat, interior tonifying for the deficiency." Japan hanako materia medica ": temperature, in tune, lower gas.Dissolving phlegm is quenched the thirst, sharp intestine and small intestine, appetizing, lower food, and kill abdomen and hide worm, only cholera is vomited and diarrhoea.
Fructus Corni, cure mainly perverse trend fever and chills under the heart, Wen Zhong, by cold temperature numbness, goes three worms, for a long time clothes made light of one's life by commiting suicide reinforcing yin essence benefit essence, five viscera settling, logical nine orifices, stop the merit of dribbling urination; Take improving eyesight, brute force for a long time all the year round.Fructus Corni, have another name called cornus officinalis sieb et zucc, medicine jujube, real jujube, fructus corni, meat jujube etc., for China commonly uses rare traditional Chinese medicine, applicating history is long.It is gentle with its benefit power, establishing-Yang and do not help fire, enriching yin and oiliness diaphragm, convergence and do not stay evil wait special efficacy like by successive dynasties medical science use.Zhang Zhongjing is that monarch has formulated " chinkuei shin chewan pills " with Fructus Corni.According to chemical analysis, Fructus Corni contains the active ingredients such as the stronger cornin of physiologically active, tartaric acid, gallic acid, malic acid, resin, tannin and multivitamin, having and strengthen immunity, anti-inflammatory, the pharmacological action such as antibacterial, is the medicine simply commonly used in tcm clinical practice.
Artemisia anomala it there is hemostasis of curing the wound, broken blood stimulates the menstrual flow, promoting digestion and removing indigestion, be amusing appetizing effect.It can be used for acute icteric hepatitis, toothache, chronic bronchitis, stomatitis, sphagitis, tonsillitis, ephritis, malaria; Eye conjunctivitis is controlled in external application, tympanitis, sore, eczema, traumatism and bleeding.Broken blood stimulates the menstrual flow, healing up sore and subduing swelling.Control through closing abdominal mass, chest and abdomen swelling and pain, postpartum blood stasis, traumatic injury, metal-inflicted wound is hemorrhage, Yong Du inflammation swell.Tang Materia Medica: " main broken blood is lower swollen." " Japan hanako materia medica ": " controls pain in the chest and abdomen, and lower air water is swollen, vim and vigour, logical married woman's passages through which vital energy circulates crux, only cholera watery diarrhea.
Cassia seed removing heat to brighten vision, relaxes bowel.For the puckery pain of hot eyes, the many tear of photophobia, have a headache dizzy, order is secretly failed to understand, constipation.Return liver, kidney, large intestine channel.There is effect of fat-reducing.Control wind-heat cute conjunctivitis, glaucoma, night blindness, hypertension, hepatitis, cirrhotic ascites, habitual constipation.The suitable symptom of cassia seed Herb Tea and crowd: cassia seed can be arranged in pairs or groups with other Herb Teas, have good greasy effect of toxin expelling oil extraction.Can effect be reached: the flat liver of heat-clearing, blood fat-reducing blood pressure-decreasing, relax bowel, improving eyesight benefit eyeball.Modern " TV race ", " cybraian " etc. easily cause the crowd of eye fatigue often to drink, but night preferably drinks less.
Specific embodiment 1:
The gardenia that airing is good is steeped in 10 times amount ethanol, heating extraction 2 times, each 1-2 hour, removes supernatant, merges extract, 100-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate reduced pressure concentration relative density is 80 DEG C 1.06 medicinal extract, heating be concentrated into paste, stand for standby use, becomes component 1.
By all the other the bulk drug dried rhizome of rehmannia, selfheal, the bark of eucommia, Radix Angelicae Sinensis, the Radix Astragali, Rhizoma Sparganii, gynostemma pentaphylla, the root bark of white mulberry, luffa, Fructus Corni, root tuber of aromatic turmeric, Artemisia anomala, cassia seed, the bighead atractylodes rhizome, hawthorn, the root bark of tree peony, the fruit of glossy privet.Put into 10 times amount ethanol, soak 1-2 hour, heating extraction 2 times, each 1-2 hour, merges extract, supernatant is removed after leaving standstill, then put into reduced pressure concentration tank, decompression recycling ethanol, being concentrated into liquor strength is 0.6g crude drug/mL, when suction filtration to the relative density of filtrate is 80 DEG C 1.06 medicinal extract, become component 2.
By component 1 and component 2-in-1 and after insert in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C, relative density is the concentrate of 1.36, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Refrigeration liquid is added the filter aid diatomite of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 0.1g crude drug amount; Paste after concentrated adds dextrin and is in harmonious proportion, and granulates, packs, take after mixing it with water after ultraviolet ray sterilization bactericidal.
Specific embodiment 2:
Get the gardenia obtained to clean, the airing time, at 7-12 hour, parches; Described gardenia 5000g is put into 5-10 times amount ethanol, soak 1-2 hour, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extract, 100-120 order filters, and is merged by No. 2 extracts and leaves standstill, decompression recycling ethanol, and to be concentrated into liquor strength be 0.6g crude drug/mL, after suction filtration, when the relative density of filtrate is about 20 DEG C 1.08; Be decompressed to 0.03-0.08MPa, temperature remains on 60-80 DEG C, and being concentrated into relative density is 1.20, and the medicinal extract of temperature to 60 DEG C-70 DEG C, as component 1.By surplus stock dried rhizome of rehmannia 1500g, selfheal 1500g, bark of eucommia 1500g, Radix Angelicae Sinensis 1500g, Radix Astragali 1500g, Rhizoma Sparganii 1500g, gynostemma pentaphylla 1500g, root bark of white mulberry 1500g, luffa 1500g, Fructus Corni 1500g, root tuber of aromatic turmeric 1500g, Artemisia anomala 1500g, cassia seed 1500g, bighead atractylodes rhizome 1500g, hawthorn 1500g, root bark of tree peony 1500g, fruit of glossy privet 1500g.Clean impurity elimination, dry, be ground into particle, soak 1 hour; Soaked raw material is put boiling secondary in multi-function extractor; Add up the water of medicinal material 10 times amount for the first time, decoct 1.5 ~ 2 hours, get decocting liquid, filter; Second time adds the water of total amount 7 times amount, decocts 1 ~ 1.2 hour, and get twice decocting liquid mixing, filtration, being concentrated into relative density is 1.20, and the medicinal extract of temperature to 60 DEG C-70 DEG C, as component 2.
; The filtrate of filtration inserted in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C, relative density is the concentrate of 1.05, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Refrigeration liquid is added the filter aid diatomite of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 1g crude drug amount.Then granulate, pack, ultraviolet disinfection, packs and get final product, and during use, direct boiling water is taken after mixing it with water.
Specific embodiment 3:
Get the gardenia obtained to clean, the airing time, at 7-12 hour, parches; Described gardenia 4500g is put into 5-10 times amount ethanol, soak 1-2 hour, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extract, 100-120 order filters, and is merged by No. 2 extracts and leaves standstill, decompression recycling ethanol, and to be concentrated into liquor strength be 0.6g crude drug/mL, after suction filtration, when the relative density of filtrate is about 20 DEG C 1.08; Be decompressed to 0.03-0.08MPa, temperature remains on 60-80 DEG C, and being concentrated into relative density is 1.20, and the medicinal extract of temperature to 60 DEG C-70 DEG C, as component 1; By other surplus stock dried rhizome of rehmannia 1200g, selfheal 1100g, bark of eucommia 1200g, Radix Angelicae Sinensis 1200g, Radix Astragali 1100g, Rhizoma Sparganii 1200g, gynostemma pentaphylla 1200g, root bark of white mulberry 1100g, luffa 1200g, Fructus Corni 1200g, root tuber of aromatic turmeric 1200g, Artemisia anomala 1300g, cassia seed 1200g, bighead atractylodes rhizome 1200g, hawthorn 1200g, root bark of tree peony 1200g, fruit of glossy privet 1100g, put it in 10 times of water gagings and soak.Drop into multi-function extractor and extract twice, first time adds 8-10 times amount soak by water 1-2 hour, and second time adds 4-8 times amount soak by water 1-2 hour, merges twice decocting liquid, filters to get filtrate; Heating is concentrated into pasty state, the gardenia component be mixed with, and granulates, ultraviolet radiation for sterilizing and disinfecting.During use, direct boiling water is taken after mixing it with water.
Pharmacological toxicity is tested
Experimental example 1: acute toxicity test of the present invention
One, test material: animal: Kunming mouse, body weight 18-25g, male and female half and half, Shandong University's biology laboratory breeding.Medicine: the present invention's (all raw material mixing decoction 2 times merges and filters, taking liquid) is containing 0.0365mg/ml.
Two, method:
1, LD50 calculates: adopt improvement karber's method, mouse is divided into 5 groups at random, often organize 10, male and female half and half, dissolve adding distil water of the present invention, are made into Cmax, by the administration of mouse maximum permission capacity, institute is followed successively by 18,14.4 to dosage by crude drug amount, 11.5,9.2,7.4 (g.kg-1), in animal fasting (can't help water) after 18 hours, administration at twice in one day (interval half an hour), each 0.5ml, observes animal dead situation.
2, maximum tolerated dose measures (MTD value): get mouse 20, each 10 of male and female.Adding distil water of the present invention is dissolved, is made into maximum concentration, by the maximal tolerance dose of animal, feed device and can twitch to inject to fill with and be as the criterion.In animal fasting (can't help water) after 18 hours, administration at twice in one day (interval half an hour), each 0.5ml (every ml containing crude drug 0.36g), total dose is 18g crude drug/kg.d, 300 times of quite clinical adult 50Kg body weight consumption.Continuous Observation 7 days after administration.
Three, result of the test:
In LD50 calculates when giving mouse with maximum acceptable concentration and maximum permission capacity (18g/Kg.d), have no dead mouse, namely LD50 is not measured, ask maximum tolerated dose only, in 7 day observation period, its appetite of animal, activity, hair color, the state of mind etc. are all normal, grow normal, there are no death.Namely select the 300 times of doses being equivalent to clinical dosage, and have no adverse reaction, show that acute toxicity is minimum, MTD > 18g/Kg.d.
Experimental example 2: the result of the test of acute toxicity and long term toxicity
Acute toxicity test: give the present invention by the disposable gavage of small white mouse, maximum concentration 35%, maximum gavage capacity 0.4ml/10g, dosage 14g/kg (every g medicinal powder is equivalent to 10g crude drug), Continuous Observation 7 days, do not find any toxic reaction, because concentration and dosage cannot increase, therefore fail to measure the LD50 of this medicine.Maximum tolerance determination: with maximum concentration, maximum gavage capacity, mice lavage administration 3 times, 5 hours, interval, then Continuous Observation 7 days, none example is dead.Medicinal powder dosage is > 42g/kg. day (every g medicinal powder is equivalent to 10g crude drug), calculates 420 times of the clinical consumption per day that is equivalent to be grown up by kg body weight.
Long term toxicity test: whether produce toxic reaction for observing long-term prescription, give rat the present invention respectively and raise clothes, by adult 70 times of clinical consumption per day and 35 times (i.e. 7g/kg/ day and 3.5g/kg/ day), give continuously and feed 8 weeks, have no the behavior of rat, feed, body weight appearance extremely, with control group ratio, routine blood test, hepatic and renal function, the change all without exception of various important organ, within the scope of institute's dosage, do not find any toxicity of the present invention.Confirmed by the acute and chronic toxicity test of animal, safe range of the present invention is comparatively large, is a kind of safe and reliable health products.
Pharmacological experiment:
1 materials and methods
1.1 material
1.1.1 medicine: the material that preparation method 2 of the present invention is obtained, decocts, is prepared into the reagent containing crude drug 9g/10ml, control group: Metformin hydrochloride (Shanghai Fahrenheit pharmacy).
1.1.2 animal Kunming mouse 96, male and female half and half, body weight (20.5 ± 2.3) g, provides by Qingdao university of TCM animal experimental center.
1.1.3 reagent and instrument: Streptozotocin (STZ) (SERVER company), purchased from magnificent company.Electronic balance AB204-WO type (plum Teller-Tuo Co., Ltd of Switzerland); Hitachi 7150 type automatic clinical chemistry analyzer (Japan).
1.2 method
1.2.1 modeling and grouping
Diabetes: animal is bought back, after adaptability feeds 1 week, be divided into normal non-diabetic group 8 and experimental group 40 at random, experimental group fasting 12 hours before modeling, modeling adopts the injection of STZ55mg/kg disposable celiac, within after administration 24 hours, survey blood sugar, glucose in urine, for three days on end, glucose in urine is qualitative +++ more than, blood glucose value is more than 16.5mmol/L, and continue constant person, be defined as diabetes and formed.
Modeling success mouse is divided into 5 groups, the high, medium and low concentration group of model control group, melbine group, decocting liquid of the present invention at random.
Hyperlipidemia: animal is bought back, after adaptability feeds 1 week, be divided into normal non-hyperlipidemia group 8 and experimental group 40 at random, experimental group fasting 12 hours before modeling, modeling gives more than 1 week containing 1% cholesterol, the high lipoprotein emulsion of 20% lard, 2% sodium taurocholate, 1% propylthio pyrimidine, every day 1 time, continuous 7 days.Modeling success mouse is divided into 5 groups, the high, medium and low concentration group of model control group, melbine group, decocting liquid of the present invention at random.
1.2.2 administration and assay method Normal group and model control group (the isopyknic physiological saline of ig); Metformin hydrochloride group (ig, 0.20g/kg); Decocting liquid group of the present invention (ig every day decocting liquid 2.0g/kg of the present invention respectively, 3.0g/kg, 4.0g/kg).Each group of difference gastric infusion, 1 time/d, continuous 30 days.12h fasting before last administration, 2h after administration, plucks eye and gets blood, measures blood sugar and blood fat with automatic clinical chemistry analyzer.
1.2.3 all data of statistical procedures represent with "-χ ± S ", data acquisition SPSS11.5 statistical software analyzing and processing, if compare homogeneity of variance One-way ANOVA between many groups, if heterogeneity of variance rank test, compare and use paired t-test before and after in group.
2 results
As shown in Table 1, the high, medium and low concentration group of decocting liquid of the present invention all significantly can reduce the blood sugar of hyperglycaemia mouse model, compares with model control group, and difference has statistical significance (P < 0.05) in 2.1 hypoglycemic experiments.
Table 1 sealwort decocting liquid is on the impact (-χ ± S) of mouse blood sugar
Note: compare with Normal group, Δ Δ P < 0.01; Compare with model control group, * P < 0.05, * * P < 0.01; NS, physiological saline.
2.3 lipopenicillinase experiment as shown in Table 2, the high, medium and low concentration of decocting liquid of the present invention all obviously can reduce TC, TG content of hyperlipemia mice model, compare with model control group, difference has statistical significance (P < 0.05, P < 0.01).
Table 2 sealwort decocting liquid is on the impact (-x ± S) of lipid of mice
Note: compare with Normal group, Δ Δ P < 0.01; Compare with model control group, * P < 0.05, * * P < 0.01; NS, physiological saline.
3 discuss
In recent years, along with improving constantly of people's living standard, the disease incidence such as diabetes, coronary heart disease increases day by day.Chinese herbal medicine effect is stablized, few side effects, and research has the Chinese herbal medicine of hypoglycemic lipid-lowering effect, can provide more method for clinical treatment diabetes, hyperlipidemia.Modern pharmacological research shows, cape jasmine property is bitter, cold, nontoxic; Gas is micro-, the micro-acid of taste and bitter; Enter the heart, liver, lung, stomach warp.Gardenia is containing flavonoids gardenin, pectin, tannin, crocin etc., and root, leaf, Hua Jieke are used as medicine, and have calmness, step-down, antibacterial, cause rush down, ease pain, anti-inflammatory, regulate smooth muscle, accelerate the effects such as the healing of soft tissue, have purging intense heat relieving restlessness, anti-inflammatory is dispelled heat, reducing fever and causing diuresis, effect of removing pattogenic heat from the blood and toxic material from the body.Gardenia bitter cold, can blood system and clear heat symptoms caused by an exopathgen, and wide intestines defaecation, anti-cancer, gardenia contains cellulose, can prevent the outbreak of hemorrhoid and the generation of carcinoma of the rectum knurl.Cape jasmine root, leaf, fruit all can be used as medicine, and have purging intense heat relieving restlessness, and anti-inflammatory is dispelled effect of heat, reducing fever and causing diuresis, removing pattogenic heat from the blood and toxic material from the body.
The present invention can reduce T-CHOL and triacylglycerol content, can clear up blood rubbish, impels the metabolism of cells in vivo; Add some promoting blood circulation and removing blood stasis, fat and serum triglyceride are all had to the Chinese medicine of obvious reducing effect, the sweet property of Radix Angelicae Sinensis, Radix Astragali taste is put down, return spleen, lung, kidney channel, have the effect of supplementing qi and nourishing yin, " Japan hanako materia medica " is said: " mending general debility ... beneficial taste, profit cardiopulmonary ".Compendium of Material Medica cloud: " mending all void ... replenishing essence marrow ".Ancients' its treatment diabete multiplex, is equivalent to the diabetes in modern medicine.This experiment, for verifying its hypoglycemic, effect for reducing fat and establishing, found that it truly has obvious hypoglycemic, effect for reducing fat.Astragalus polyose, can reduce the content of the cAMP in liver cell thus hinder phosphorylase to activate and Glycogen synthesis enzyme deactivation, causes that Glycogen synthesis accelerates, Glycogen synthesis slows down, thus reduces blood sugar; Its effect for reducing fat may be relevant with the anti-oxidative damage of astragalus polyose, immunological regulation, suppression inflammatory factor.In sum, gardenia, Radix Angelicae Sinensis, the fruit of glossy privet, the Radix Astragali etc. have good hypoglycemic lipid-lowering effect, can be used for treatment diabetes and hyperlipidemia clinically.Experimental result shows, the present invention all has obvious reducing effect to Mouse Weight, fat and serum triglyceride, and can improve microcirculation, and hypoglycemic effect for reducing blood fat has been described.
Claims (10)
1. a gardenia hypoglycemic health protection tea, it is characterized in that, described gardenia hypoglycemic health protection tea comprises the raw material of following parts by weight: gardenia 10 ~ 50 parts, 10 ~ 20 parts, the dried rhizome of rehmannia, selfheal 10 ~ 20 parts, the bark of eucommia 10 ~ 20 parts, Radix Angelicae Sinensis 10 ~ 20 parts, the Radix Astragali 10 ~ 20 parts, Rhizoma Sparganii 10 ~ 20 parts, gynostemma pentaphylla 10 ~ 20 parts, the root bark of white mulberry 10 ~ 20 parts, luffa 10 ~ 20 parts, Fructus Corni 10 ~ 20 parts, root tuber of aromatic turmeric 10 ~ 20 parts, Artemisia anomala 10 ~ 20 parts, cassia seed 10 ~ 20 parts, the bighead atractylodes rhizome 10 ~ 20 parts, hawthorn 10 ~ 20 parts, the root bark of tree peony 10 ~ 20 parts, the fruit of glossy privet 10 ~ 20 parts.
2. gardenia hypoglycemic health protection tea according to claim 1, it is characterized in that, in described gardenia hypoglycemic health protection tea, the parts by weight of various raw material are: gardenia 10 ~ 40 parts, 10 ~ 15 parts, the dried rhizome of rehmannia, selfheal 10 ~ 15 parts, the bark of eucommia 10 ~ 15 parts, Radix Angelicae Sinensis 10 ~ 15 parts, the Radix Astragali 10 ~ 15 parts, Rhizoma Sparganii 10 ~ 15 parts, gynostemma pentaphylla 10 ~ 15 parts, the root bark of white mulberry 10 ~ 15 parts, luffa 10 ~ 20 parts, Fructus Corni 10 ~ 20 parts, root tuber of aromatic turmeric 10 ~ 20 parts, Artemisia anomala 10 ~ 20 parts, cassia seed 10 ~ 20 parts, the bighead atractylodes rhizome 10 ~ 20 parts, hawthorn 10 ~ 20 parts, the root bark of tree peony 10 ~ 20 parts, the fruit of glossy privet 10 ~ 20 parts.
3. gardenia hypoglycemic health protection tea according to claim 1, it is characterized in that, in described gardenia hypoglycemic health protection tea, the parts by weight of various raw material are: gardenia 10 ~ 30 parts, 10 ~ 20 parts, the dried rhizome of rehmannia, selfheal 10 ~ 20 parts, the bark of eucommia 10 ~ 20 parts, Radix Angelicae Sinensis 10 ~ 20 parts, the Radix Astragali 10 ~ 20 parts, Rhizoma Sparganii 10 ~ 20 parts, gynostemma pentaphylla 10 ~ 20 parts, the root bark of white mulberry 10 ~ 20 parts, luffa 10 ~ 15 parts, Fructus Corni 10 ~ 15 parts, root tuber of aromatic turmeric 10 ~ 15 parts, Artemisia anomala 10 ~ 15 parts, cassia seed 10 ~ 15 parts, the bighead atractylodes rhizome 10 ~ 15 parts, hawthorn 10 ~ 15 parts, the root bark of tree peony 10 ~ 15 parts, the fruit of glossy privet 10 ~ 15 parts.
4. the preparation method of gardenia hypoglycemic health protection tea as described in any one of claims 1 to 3 item, it is characterized in that, the preparation process of described gardenia hypoglycemic health protection tea comprises following aspect:
A. the preparation of gardenia, becomes component 1;
B. by concentration of liquid medicine that all the other raw materials extract; Become component 2;
D. component 1, component 2 are mixed, after concentrated granulation, sterilizing, tea-drinking is worked as in pack.
5. the preparation method of gardenia hypoglycemic health protection tea according to claim 4, is characterized in that, in described step a, get the gardenia obtained and clean, the airing time, at 7-12 hour, parches; Described gardenia is put into 5-10 times amount ethanol, soak 1-2 hour, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extract, 100-120 order filters, and is merged by No. 2 extracts and leaves standstill, decompression recycling ethanol, and to be concentrated into liquor strength be 0.6g crude drug/mL, after suction filtration, when the relative density of filtrate is about 20 DEG C 1.08; Be decompressed to 0.03-0.08MPa, temperature remains on 60-80 DEG C, and being concentrated into relative density is 1.20, and the medicinal extract of temperature to 60 DEG C-70 DEG C, as component 1.
6. the preparation method of gardenia hypoglycemic health protection tea according to claim 4, is characterized in that, in described step b, surplus stock is cleaned impurity elimination, dry, be ground into particle, soak 1 hour; Soaked raw material is put boiling secondary in multi-function extractor; Add up the water of medicinal material 10 times amount for the first time, decoct 1.5 ~ 2 hours, get decocting liquid, filter; Second time adds the water of total amount 7 times amount, decocts 1 ~ 1.2 hour, and get twice decocting liquid mixing, filtration, being concentrated into relative density is 1.20, and the medicinal extract of temperature to 60 DEG C-70 DEG C, as component 2.
7. the preparation method of gardenia hypoglycemic health protection tea according to claim 4, is characterized in that, in described step c, by also 2-in-1 to component 1 and component, insert in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C, relative density is the concentrate of 1.25, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Will refrigeration liquid add 0.3% filter aid diatomite, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 0.1g crude drug amount, and then add dextrin and put into granulator and granulate, ultraviolet disinfection, packs and get final product.
8. the preparation method of gardenia hypoglycemic health protection tea according to any one of claims 1 to 3, it is characterized in that, its preparation process can also be:
A. the preparation of gardenia, as component 1;
B. all the other bulk drugs described added alcohol immersion, extract 3 times as component 2;
C. component 1 and component 2 are mixed, add appropriate propolis after concentrated and be in harmonious proportion, bottle after ultraviolet ray sterilization bactericidal.
9. the preparation method of gardenia hypoglycemic health protection tea according to claim 8, is characterized in that, in described step a, the gardenia of clean airing is put in 10 times amount ethanol, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extract, 100-120 order filters, then is the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, when ultrafiltrate reduced pressure concentration relative density is 80 DEG C 1.06 medicinal extract, heating is concentrated into paste, stand for standby use, becomes component 1.
10. the preparation method of gardenia hypoglycemic health protection tea according to claim 8, is characterized in that, in described step b, all the other raw materials described are put into 5-10 times amount ethanol, soaks 1-2 hour, heating extraction 2 times, each 1-2 hour, removes supernatant, merges extract, 100-120 order filters, No. 2 extracts are merged and leaves standstill, decompression recycling ethanol, and to be concentrated into liquor strength be 0.6g crude drug/mL, after suction filtration, when the relative density of filtrate is about 20 DEG C 1.08; Be decompressed to 0.03-0.08MPa, temperature remains on 60-80 DEG C, and being concentrated into relative density is 1.20, and the medicinal extract of temperature to 60 DEG C-70 DEG C, as component 2.
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| CN113197907A (en) * | 2021-06-21 | 2021-08-03 | 江西中医药大学 | Application of gardenia acetic acid and derivatives thereof in preparing medicine for treating diabetes |
| CN113397016A (en) * | 2021-07-12 | 2021-09-17 | 陕西理工大学 | Preparation method of dogwood and hawthorn table tea for reducing blood sugar |
| CN114041596A (en) * | 2021-11-11 | 2022-02-15 | 肖国红 | Food composition for hypertension treatment of patients and preparation method thereof |
| CN116898931A (en) * | 2022-10-17 | 2023-10-20 | 创庭生物科技(上海)有限公司 | An oral preparation for assisting in reducing blood viscosity |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107173481A (en) * | 2017-06-27 | 2017-09-19 | 黔西南州天麒绿色产业开发有限公司 | A kind of health protection tea of three high drop and preparation method thereof |
| CN113197907A (en) * | 2021-06-21 | 2021-08-03 | 江西中医药大学 | Application of gardenia acetic acid and derivatives thereof in preparing medicine for treating diabetes |
| CN113397016A (en) * | 2021-07-12 | 2021-09-17 | 陕西理工大学 | Preparation method of dogwood and hawthorn table tea for reducing blood sugar |
| CN113397016B (en) * | 2021-07-12 | 2022-08-02 | 陕西理工大学 | Preparation method of dogwood and hawthorn table tea for reducing blood sugar |
| CN114041596A (en) * | 2021-11-11 | 2022-02-15 | 肖国红 | Food composition for hypertension treatment of patients and preparation method thereof |
| CN116898931A (en) * | 2022-10-17 | 2023-10-20 | 创庭生物科技(上海)有限公司 | An oral preparation for assisting in reducing blood viscosity |
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