CN103734424B - A kind of bitter buckwheat Weight-reducing and lipid-lowering constipation-relieving tea and preparation method thereof - Google Patents

A kind of bitter buckwheat Weight-reducing and lipid-lowering constipation-relieving tea and preparation method thereof Download PDF

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CN103734424B
CN103734424B CN201310745170.8A CN201310745170A CN103734424B CN 103734424 B CN103734424 B CN 103734424B CN 201310745170 A CN201310745170 A CN 201310745170A CN 103734424 B CN103734424 B CN 103734424B
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bitter buckwheat
blood
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weight
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管玉贞
王宝娥
王敏
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Zhejiang Parkway health praise Product Management Co. Ltd.
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Qingdao Huaren Technology Incubator Co Ltd
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Abstract

The invention provides a kind of bitter buckwheat Weight-reducing and lipid-lowering constipation-relieving tea, the parts by weight of various raw material are: bitter buckwheat 10 ~ 50 parts, purslane 10 ~ 20 parts, flower of hyacinth dolichos 10 ~ 20 parts, 10 ~ 20 parts, the dried rhizome of rehmannia, the root bark of Chinese wolf-berry 10 ~ 20 parts, cogongrass rhizome 10 ~ 20 parts, 10 ~ 20 parts, Poria cocos, the red sage root 10 ~ 20 parts, 10 ~ 20 parts, lotus leaf, eupatorium 10 ~ 20 parts, gynostemma pentaphylla 10 ~ 20 parts, the root bark of white mulberry 10 ~ 20 parts, Fructus Corni 10 ~ 20 parts, root tuber of aromatic turmeric 10 ~ 20 parts, rhizoma cyperi 10 ~ 20 parts, the Radix Astragali 10 ~ 20 parts, heart of a lotus seed benevolence 10 ~ 20 parts, the bighead atractylodes rhizome 10 ~ 20 parts, hawthorn 10 ~ 20 parts, motherwort 10 ~ 20 parts.Bitter buckwheat gut purge, ease constipation, defaecation, can affect HypercholesterolemicRats, significantly can reduce the cholesterol in serum and liver.Add that some are promoting blood circulation and removing blood stasis, fat and serum triglyceride are all had to the Chinese medicine of obvious reducing effect, can improve microcirculation, the most mouthfeel of these medicinal materials is light, does not affect bitter Qiao Chaweidao, makes people be easy to accept, can reach effect of lowering blood-fat and reducing weight preferably.

Description

A kind of bitter buckwheat Weight-reducing and lipid-lowering constipation-relieving tea and preparation method thereof
Technical field
The present invention relates to the slimming health product containing deriving from plant composition, particularly one bitter buckwheat Weight-reducing and lipid-lowering constipation-relieving tea and preparation method thereof.
Background technology
Day by day flourishing due to economy, the continuous lifting of modern's living standard, cause people too much have deep love for enjoy, do not notice that the life style of oneself, behavioural habits, diet are had a liking for, thus the disease caused.Society with fast rhythm lives, the operating pressure of keen competition, serious threat is caused to the physical and mental health of modern, people more than half is made to be in sub-health state, show as: dizzy, nervous, weak, poor appetite, failure of memory, insomnia, indifferent to etc. to thing, in addition, long-term diet is unreasonable, that is: smart grain replaces coarse food grain completely, a large amount of three height (high heat, high protein, higher fatty acid), more than three, (anticorrisive agent is many, flavoring agent is many, hormone is many) agricultural chemicals residual in the absorption of food and food, chemical fertilizer stockpiling in vivo, add air, pollution of waterhead and amount of exercise less than normal, go down to make three high disease (hypertension for a long time like this, hyperglycaemia, high fat of blood), cardiovascular and cerebrovascular disease, cancers etc. so-called " modern civilization diseases " rise rapidly, and constantly rejuvenation, the serious health and lives jeopardizing the mankind.
Social change rapidly and the continuous renewal of life style, expedited the emergence of the serious advanced old and feeble of people's physiological age, wherein city white collar more so.In the booming income crowd in 35-50 year, " biological age " overage trend is obviously accelerated, and generally exceeds actual age about 10 years old.If namely actual age only has 40 years old, and physiological age has had 50 years old.In the face of so general phenomenon, someone jokes and is referred to as " generation that speed is rotten ".
Along with industrialized development, the change of dietary structure, the improvement of living condition, the quantity of Overweight and obesity crowd worldwide increases rapidly, and in the trend of becoming younger, become global and have a strong impact on healthy epidemic disease, therefore, the effective method of weight-reducing of search of health has very real significance, and anti-obesity activity material is the key that people expect to solve problem of obesity always safely and effectively.Weight-reducing and lipid-lowering method is a lot, has dietetic treatment, kinesiatrics, medicinal treatment and clinical treatment etc. and these methods more or less have weak point, and what have also easily causes side effect, as diarrhoea, apocleisis etc.And the fat-reducing of defaecation articles for use has easy to use, have no side effect, the features such as effect is remarkable, and extremely consumers.
The high speed development of Modern Urban Living, also brings a series of rich man's disease.Wherein " three is high " and obesity are the primary enemies of puzzlement people." three high diseases " refers to hypertension, hyperglycaemia (diabetes) and hyperlipemia.Usually along with obesity.They be modern society derive from " rich man's disease ", possible individualism, also may be interrelated.As: diabetes patient is easy to suffer from hypertension or hyperlipemia simultaneously, and high fat of blood is the principal element of artery sclerosis formation and development, and arteriosclerotic's blood vessel elasticity difference aggravation blood pressure raises, so the later stage all defines " three high diseases ".Be what has statistics about three height, in the Chinese ten large causes of death, the death rate relevant to metabolic disease is just up to 35.7%, and the death toll relevant to " three is high " also accounts for 27% of total death toll.High fat of blood can cause blood vessel embolism; Hypertension can cause cerebral hemorrhage and rupture of blood vessel in brain; Hyperglycaemia can cause diabetes.The World Health Organization once clearly proposed, and prevented the first line of defence of cardiovascular disease from reducing " three is high " exactly and controlling " three is high ".A lot of diabetes patient is with hyperlipidemia, and therefore diabetes and hyperlipidemia, people call that sister is sick usually, and think that high fat of blood is the secondary disease of diabetes.The diabetic of about 40% has disorders of lipid metabolism according to statistics.Be characterized in that triglycerides increases to reduce with HDL.When the reason that diabetes cause blood fat to increase is due to diabetes patient's insufficient insulin, body lactonase activity lowers, and therefore easily blood fat increases.Diabetes itself also accompany fat, protein and water, dielectric disorder except carbohydrate metabolism disturbance simultaneously on the other hand.Often there is free fatty to mobilize out from fat depot, triglycerides and FFA concentrations in blood are increased.Diabetes B people takes food too much on the one hand again, and motion is few, and impel lipid synthesis in body to increase, this is also the reason causing blood fat to increase.And fat companion's high fat of blood person, because insulin receptor number reduces relatively, thus produce insulin resistance, easy induced Diabetic.Blood fat increased perosn also easily causes the heart, cerebrovascular complication.
Bitter buckwheat is the medicine-food two-purpose crop that occurring in nature is very few, records: bitter buckwheat bitter according to Compendium of Material Medica, and property is flat cold, the real stomach of energy, beneficial strength, continuous spirit, sharp knowledge, and refining the five internal organs slag is dirty; All on the books to bitter buckwheat in Thousand Golden Prescriptions, " Chinese medicine voluminous dictionary " and pertinent literature: can calm the nerves, wind pain is swollen in the wide intestines of lively atmosphere blood, sending down abnormally ascending, heat-clearing, long-pendingization of dispelling is stagnant, gut purge, ease constipation, defaecation, cough-relieving, relieving asthma, anti-inflammatory, antiallergy, cardiac stimulant, fat-reducing, the effect such as beauty treatment., be not medicine, be not defaecation product to bitter buckwheat-seven major nutrient complete set, is work as the food that meal eats, and but has the nutrition defaecation of brilliance value and outstanding dietotherapy effect.It does not belong to grass family, and belongs to polygonaceae, with people the fleece-flower root, rheum officinale etc. be familiar be blood brother, being the outstanding grain medicine dual-purpose grain kind that international food and agricultural organization generally acknowledges, is that the typical case of China's integration of drinking and medicinal herbs culture embodies.Bitter buckwheat is described as " kings of five cereals ", and three fall food (hypotensive, hypoglycemic, reducing blood lipid).Produce in high and cold mountain area, Southwest China, northwest and Shanxi north one band, the representative main place of production has: the ground such as Hua Ling mountain, Tongwei, Gansu, autonomous prefecture of the Sichuan Liangshan District Yi nationality, distributed over Yunnan, Sichuan and Guizhou.Green natural, pure in dye, and nutritive value is different because the place of production is different.Bitter buckwheat has uniqueness, comprehensive, abundant nutrition, and medicinal characteristic is good, has the necessary multiple nutrients composition of human body, so be described as " the natural gold partner " of the mankind by worldwide nutrition scholar.
Bitter buckwheat energy anti-inflammation, has the laudatory title of " anti-inflammatory grain ".Bitter buckwheat has effect of catharsis and toxin expelling, is among the peoplely called again " clean intestines grass ".The number that China dies from the disease directly relevant with medicine is every year 250,000, for a long time, medical circle is striving to find effect of a kind of existing medicine always, does not have again the food applications of side effects of pharmaceutical drugs in clinical simultaneously, now, people have found this desirable food of duck wheat finally.
The various fat-reducing defaecation product sold on the market now, dragons and fishes jumbled together for medicine, the cathartic that great majority are just simple, people is allowed to dewater in a large number, cause the huge injury of the person, therefore, the effective method of weight-reducing of search of health has very real significance, and anti-obesity activity material is the key that people expect to solve problem of obesity always safely and effectively.Traditional Chinese medicine capable of reducing weight, having advantage that is nontoxic, that can be absorbed completely by organism, is the Main way that we study.There are reducing blood lipid, antibacterial, hypoglycemic, antioxidation in present market in the urgent need to developing one, and energy interference body is to the absorption of fat, promotes the diet products that the fat taken in excretes, and has advantage that is nontoxic, that can be absorbed completely by organism.
Summary of the invention
Technical problem to be solved by this invention is, dragons and fishes jumbled together for most of diet products in present market, and most just simple cathartic, allows people dewater in a large number, cause the illusion that body weight for humans alleviates.But can cause huge injury to the person, therefore, the effective method of weight-reducing of search of health has very real significance, anti-obesity activity material is the key that people expect to solve problem of obesity always safely and effectively.Modern medicine study, bitter buckwheat can reduce serum total cholesterol and triacylglycerol content, slows down atherogenesis; Add some promoting blood circulation and removing blood stasis, fat and serum triglyceride are all had to the Chinese medicine of obvious reducing effect, and can improve microcirculation, the most mouthfeel of these medicinal materials is light, does not affect tea flavour road, makes people be easy to accept, more can reach effect of lowering blood-fat and reducing weight preferably.
For solving above-mentioned technical barrier, the invention provides a kind of bitter buckwheat Weight-reducing and lipid-lowering constipation-relieving tea, in described bitter buckwheat Weight-reducing and lipid-lowering constipation-relieving tea, the parts by weight of various raw material are: bitter buckwheat 10 ~ 50 parts, purslane 10 ~ 20 parts, flower of hyacinth dolichos 10 ~ 20 parts, 10 ~ 20 parts, the dried rhizome of rehmannia, the root bark of Chinese wolf-berry 10 ~ 20 parts, cogongrass rhizome 10 ~ 20 parts, 10 ~ 20 parts, Poria cocos, the red sage root 10 ~ 20 parts, 10 ~ 20 parts, lotus leaf, eupatorium 10 ~ 20 parts, gynostemma pentaphylla 10 ~ 20 parts, the root bark of white mulberry 10 ~ 20 parts, Fructus Corni 10 ~ 20 parts, root tuber of aromatic turmeric 10 ~ 20 parts, rhizoma cyperi 10 ~ 20 parts, the Radix Astragali 10 ~ 20 parts, heart of a lotus seed benevolence 10 ~ 20 parts, the bighead atractylodes rhizome 10 ~ 20 parts, hawthorn 10 ~ 20 parts, motherwort 10 ~ 20 parts.
Described bitter buckwheat Weight-reducing and lipid-lowering constipation-relieving tea, in bitter buckwheat Weight-reducing and lipid-lowering constipation-relieving tea described in it, the parts by weight of various raw material can be: bitter buckwheat 10 ~ 30 parts, purslane 10 ~ 15 parts, flower of hyacinth dolichos 10 ~ 15 parts, 10 ~ 15 parts, the dried rhizome of rehmannia, the root bark of Chinese wolf-berry 10 ~ 15 parts, cogongrass rhizome 10 ~ 15 parts, 10 ~ 15 parts, Poria cocos, the red sage root 10 ~ 15 parts, 10 ~ 15 parts, lotus leaf, eupatorium 10 ~ 15 parts, gynostemma pentaphylla 10 ~ 20 parts, the root bark of white mulberry 10 ~ 20 parts, Fructus Corni 10 ~ 20 parts, root tuber of aromatic turmeric 10 ~ 20 parts, rhizoma cyperi 10 ~ 20 parts, the Radix Astragali 10 ~ 20 parts, heart of a lotus seed benevolence 10 ~ 20 parts, the bighead atractylodes rhizome 10 ~ 20 parts, hawthorn 10 ~ 20 parts, motherwort 10 ~ 20 parts.
Described bitter buckwheat Weight-reducing and lipid-lowering constipation-relieving tea, in bitter buckwheat Weight-reducing and lipid-lowering constipation-relieving tea described in it, the parts by weight of various raw material can also compare: bitter buckwheat 10 ~ 30 parts, purslane 10 ~ 20 parts, flower of hyacinth dolichos 10 ~ 20 parts, 10 ~ 20 parts, the dried rhizome of rehmannia, the root bark of Chinese wolf-berry 10 ~ 20 parts, cogongrass rhizome 10 ~ 20 parts, 10 ~ 20 parts, Poria cocos, the red sage root 10 ~ 20 parts, 10 ~ 20 parts, lotus leaf, eupatorium 10 ~ 20 parts, gynostemma pentaphylla 10 ~ 15 parts, the root bark of white mulberry 10 ~ 15 parts, Fructus Corni 10 ~ 15 parts, root tuber of aromatic turmeric 10 ~ 15 parts, rhizoma cyperi 10 ~ 15 parts, the Radix Astragali 10 ~ 15 parts, heart of a lotus seed benevolence 10 ~ 15 parts, the bighead atractylodes rhizome 10 ~ 15 parts, hawthorn 10 ~ 15 parts, motherwort 10 ~ 15 parts.
For solving the problems of the technologies described above, the present invention also provides a kind of preparation method of bitter buckwheat Weight-reducing and lipid-lowering constipation-relieving tea, and the preparation process of described bitter buckwheat Weight-reducing and lipid-lowering constipation-relieving tea comprises following aspect:
A. the preparation of bitter buckwheat;
B. described other raw materials pulverized, soak, heating, refluxing extraction 2 times;
C. again the concentration of liquid medicine that surplus stock extracts is become granule, pulvis or paste;
D. concentrated granule, pulvis or paste are mixed with the bitter buckwheat prepared, be prepared into defaecation medicinal tea.
In described step a, can get the duck wheat obtained and clean, the airing time, at 7-12 hour, parches; Bitter buckwheat good for airing is put into the pot that completes and goes green grass or young crops, complete 20-30 minute at 70-100 DEG C, then puts into large iron pan and stir-fry, and on first backward downwards, firmly wants evenly, when buckwheat color starts jaundice, start little fire stir-fry 10-15 minute shaping; Naturally dry after taking out.
In described step b, surplus stock can be cleaned impurity elimination, dry, be ground into particle, soak 1 hour; Soaked raw material is put boiling secondary in multi-function extractor; Add up the water of medicinal material 10 times amount for the first time, decoct 1.5 ~ 2 hours, get decocting liquid, filter; Second time adds the water of total amount 7 times amount, decocts 1 ~ 1.2 hour, gets twice decocting liquid mixing, filters.
In described step c, the filtrate of filtration can be inserted in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C, relative density is the concentrate of 1.05, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Will refrigeration liquid add 0.3% filter aid diatomite, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 1g crude drug amount, then adds dextrin and puts into granulator and granulate.
In described steps d, bitter buckwheat good for frying can be mixed with particle prepared by surplus stock, ultraviolet disinfection, packs and get final product.
For solving the problems of the technologies described above, the present invention reoffers a kind of preparation method of bitter buckwheat Weight-reducing and lipid-lowering constipation-relieving tea, the preparation method of described bitter buckwheat Weight-reducing and lipid-lowering constipation-relieving tea can also be: when other raw materials being made pulvis, step is: other raw materials can be put into 10 times amount ethanol, heating and refluxing extraction 2 times, each 1 ~ 2 hour, No. 2 extracts are merged and leaves standstill; The dregs of a decoction of the component raw medicinal material crossed by above-mentioned alcohol extract again add 10 times of water gaging heating and refluxing extraction 2 times, each 1 ~ 2 hour, are merged by No. 2 extracts and leave standstill; Merged by above-mentioned two kinds of extracts, reducing pressure after reclaiming ethanol, it is concentrated to put into inspissator, and by gained concentrate adjustment proportion to 1.06, decompression, then put into drying baker and be dried into powder, bitter buckwheat good with frying after ultraviolet radiation for sterilizing and disinfecting merges to be packed.
Two kinds of extracts, in above-mentioned concentration step, are merged by the preparation method of described bitter buckwheat Weight-reducing and lipid-lowering constipation-relieving tea, after reclaiming ethanol decompression put into inspissator concentrated time, when being concentrated into 90 DEG C, relative density is the concentrate of 1.05, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Refrigeration liquid is added the filter aid diatomite of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 1g crude drug amount.
The technique effect that the present invention is useful is, the present invention has advantage that is nontoxic, that can be absorbed completely by organism.Bitter buckwheat not only can effectively promoting blood circulation and removing blood stasis, embolism resistance, reducing blood lipid, hypotensive, reduce cholesterol, reduce blood sugar, the composition of blood is purified, but also the fragility of microcirculation, reduction capillary can be improved, reduce its permeability, impaired vascular wall can be repaired; Add some promoting blood circulation and removing blood stasis, fat and serum triglyceride are all had to the Chinese medicine of obvious reducing effect, and can microcirculation be improved, the most mouthfeel of these medicinal materials is light, do not affect the taste of bitter buckwheat tea, make people be easy to accept, more can reach effect of lowering blood-fat and reducing weight preferably.
Detailed description of the invention
Bitter buckwheat is rich in linoleic acid, rutin, Quercetin, phytosterol, selenium, chromium, manganese.The pathologic lesion to acute pancreatitis can be alleviated; protection pancreatic tissue; strengthen insulin peripheral action; anti peroxidation of lipid; suppress oxidative modification of high density lipoprotein, promote that cholesterol degradation is cholic acid excretion, reduce the permeability of capillary; hemangiectasis, strengthens ascorbic effect and promotes vitamin accumulation in vivo
Bitter buckwheat is the medicine-food two-purpose crop that occurring in nature is very few, records: bitter buckwheat bitter according to Compendium of Material Medica, and property is flat cold, the real stomach of energy, beneficial strength, continuous spirit, sharp knowledge, and refining the five internal organs slag is dirty; All on the books to bitter buckwheat in Thousand Golden Prescriptions, " Chinese medicine voluminous dictionary " and pertinent literature: can calm the nerves, wind pain is swollen in the wide intestines of lively atmosphere blood, sending down abnormally ascending, heat-clearing, long-pendingization of dispelling is stagnant, gut purge, ease constipation, defaecation, cough-relieving, relieving asthma, anti-inflammatory, antiallergy, cardiac stimulant, fat-reducing, the effect such as beauty treatment., be not medicine, be not defaecation product to bitter buckwheat one seven major nutrient complete set, is work as the food that meal eats, and but has the nutrition defaecation of brilliance value and outstanding dietotherapy effect.It does not belong to grass family, and belongs to polygonaceae, with people the fleece-flower root, rheum officinale etc. be familiar be blood brother, being the outstanding grain medicine dual-purpose grain kind that international food and agricultural organization generally acknowledges, is that the typical case of China's integration of drinking and medicinal herbs culture embodies.Bitter buckwheat is described as " kings of five cereals ", and three fall food (hypotensive, hypoglycemic, reducing blood lipid).Produce in high and cold mountain area, Southwest China, northwest and Shanxi north one band, the representative main place of production has: the ground such as Hua Ling mountain, Tongwei, Gansu, autonomous prefecture of the Sichuan Liangshan District Yi nationality, distributed over Yunnan, Sichuan and Guizhou.Green natural, pure in dye, and nutritive value is different because the place of production is different.Bitter buckwheat has uniqueness, comprehensive, abundant nutrition, and medicinal characteristic is good, has the necessary multiple nutrients composition of human body, so be described as " the natural gold partner " of the mankind by worldwide nutrition scholar.Bitter buckwheat energy anti-inflammation, has the laudatory title of " anti-inflammatory grain ".Bitter buckwheat has effect of catharsis and toxin expelling, is among the peoplely called again " clean intestines grass ".The number that China dies from the disease directly relevant with medicine is every year 250,000.For a long time, medical circle is striving to find effect of a kind of existing medicine always, and do not have again the food applications of side effects of pharmaceutical drugs in clinical, now, people have found this desirable food of duck wheat finally simultaneously.
Bitter buckwheat is rich in bioflavonoid, linoleic acid, chromium element.Bitter buckwheat flavone not only can effectively promoting blood circulation and removing blood stasis, embolism resistance, reducing blood lipid, hypotensive, reduce cholesterol, reduce blood sugar, the composition of blood is purified, but also the fragility of microcirculation, reduction capillary can be improved, reduce its permeability, impaired vascular wall can be repaired.Bitter buckwheat is called " three fall pellet " by modern.
Lotus leaf contains multiple alkaloid and vitamin C, the polysaccharide such as nuciferine (Roemerine), miltanthin (Pronuciferine) and Nuciferine (Nuciferine).There is the effect of clearing heat and detoxicating, cool blood, hemostasis.There are the effects such as clearing summer-heat and damp, sending up the lucid yang, cooling blood and hemostasis.Modern study shows, lotus leaf also has effect for reducing blood fat, so a lot of fat-reducing, lipopenicillinase, all contain lotus leaf in product for resolving poxes.Cure mainly hot summer weather polydipsia, have a headache dizzy, oedema, the few abdominal distension of food, rush down dysentery, leukorrhea, prolapse of the anus, spit blood, bleeding from five sense organs or subcutaneous tissue, spitting of blood, has blood in stool, uterine bleeding, post partum longtime lochia, traumatic blood stasis.
Gynostemma pentaphylla finds through modern medicine study, gynostemma pentaphylla principle active component is polysaccharide, flavonoids, saponins and microelement kind, its effect mainly promotes body fat class metabolism, nutrition human body cell, there is good detoxicating, relieving inflammation effect simultaneously, be widely used in high fat of blood, fatty liver, obesity, constipation, insomnia, hepatitis B, the treatment of chronic airway inflammation (sphagitis, enterogastritis etc.) and defaecation.
Poria cocos taste is sweet, light, property is put down, and is used as medicine and has the function of clearing damp and promoting diuresis, beneficial spleen and stomach, antitoxic heart-soothing and sedative.Modern medicine study: Poria cocos energy enhanced machine body immunity function, pachymaran has significantly antitumor and protect the liver dirty effect.Poria cocos slightly sweet flavor is put down, and enters the heart, lung, the spleen channel.There is eliminating dampness and diuresis, strengthening the spleen and stomach, effect of antitoxic heart-soothing and sedative.Can control difficult urination, oedema turgor, phlegm and retained fluid is coughed inverse, vomits inverse, and vomiting during early pregnancy, has loose bowels, seminal emission, stranguria with turbid discharge, palpitation with fear, forgetful disease such as grade.The Li Shui of Poria cocos, is reached by strong fortune spleen PFT, different from the Chinese medicine of other direct Li Shui.For splenasthenic diarrhea, the lower Poria cocos of band can invigorating the spleen, again can excreting dampness, and for having loose bowels caused by insufficiency of the spleen dysfunction of the spleen in transportation and transformation, being with down, application Poria cocos has the effect of giving consideration to both the incidental and fundamental, the compatibilities such as normal and lotus leaf, the bighead atractylodes rhizome, Chinese yam.Can be used as tonifying lung spleen, control the adjuvant of the deficiency of vital energy.
Eupatorium expelling summer-heat and damp, ward off dirty and in.Cure mainly and experience summer-heat and damp; Fever and chills are had a headache; Accumulate in moistening; Gastral cavity ruffian is not hungry; N and V; Sweet greasy in mouthful; Disappear truly. " Bencao Jingshu ": lung governing qi, lung qi pent-up, then upper orifices is closed and lower orifices are obstructed, the main Na Shuigu of stomach, stagnation of stomach-QI, then water paddy not with time and be phlegm addiction, fragrant thoroughwort pungent flat can dissipating bind stagnant, fragrance can remove dirty evil, then come up all cards from recover, mostly appetizing is except disliking, and clearing lung-heat dissolving phlegm, the panacea of Disperse hepatic depression also." key medicine divides agent ": fragrant thoroughwort, for dissolving phlegm except disliking, the product of loose Yu Xiejie, "Nei Jing" is quenched one's thirst treating with Herba EuPatorii, and removing the accumulation of stale pathogen is also.Lid is quenched one's thirst by heat symptoms caused by an exopathgen pent-up in stomach, blue energy removing the accumulation of stale pathogen.Known fragrant thoroughwort is solid to cleanse for merit, eliminates stomach person also.
Heart of a lotus seed benevolence is conventional Chinese medicine. be again the food generally, often eaten, property slightly sweet flavor is slightly cold, and has inducing diuresis for removing edema, invigorating the spleen is dried, relaxing muscles and tendons removes the effect such as numbness, clearing away heat and eliminating pus, is conventional damp-clearing drug.Heart of a lotus seed benevolence is again a kind of beauty food, and normal food can keep human body skin gloss fine and smooth, eliminates acne, spot sparrow, senile plaque expelling, cyasma, butterfly macules, to furfur, acne, chap, pachylosis etc. has good efficacy.The kind Renhe root of the seed of Job's tears can be used as medicine again and cure the disease.Li Shizhen (1518-1593 A.D.) is recorded in Compendium of Material Medica: seed of Job's tears energy, and " invigorating spleen and reinforcing stomach, tonifying lung heat-clearing, removes wind prevailing over dampness.To cook a meal food, control cold air.Decoct drink, diuresis heat is drenched." in recent years, a large amount of scientific researches and clinical practice prove, the seed of Job's tears or a kind of cancer therapy drug, and Preliminary Identification, it can reach more than 35% to the inhibiting rate of cancer.
Bighead atractylodes rhizome bitter, sweet, temperature.Return spleen, stomach warp.Cure mainly strengthening the spleen and replenishing qi, eliminating dampness Li Shui, hidroschesis, antiabortive.Few for insufficiency of the spleen food, abdominal distension is had loose bowels, and phlegm and retained fluid is dizzy throbs with fear, oedema, spontaneous perspiration, fetal irritability.The bighead atractylodes rhizome has CDCC to oncocyte, can reduce the rate of increase of oncocyte, lowers the aggressive of tumor tissue, improves the ability of the antitumor reaction of body.Baizhu volatile oil has inhibitory action to mouse EC, lymphosarcoma ascitic type, the cancer of the esophagus (Ecal09), sarcoma 180 etc.Atractylodes lactone B lumbar injection is to the murine sarcoma people.Also remarkable inhibitory action is had." property of medicine opinion " carries it: monarch, taste is sweet, pungent, nontoxic.Energy main large wandering arthritis, for many years diarrhea due to disorder of qi, trusted subordinate's distending pain, the broken place food that disappears, appetizing, removes sputum, except fever and chills, lets out under stopping.Interarea light is pleased, and preserves youthful looks, de-black.Swelling of harnessing the river is full, tells to vomit inverse, and crymodynia in abdomen, vomits and diarrhoea incessantly, and the cold dysentery of stomach Qi deficiency.
The red sage root is bitter, is slightly cold.The thoughts of returning home, Liver Channel.Stasis-dispelling and pain-killing, activating blood to promote menstruation, clear away heart-fire relieving restlessness.For irregular menstruation, through closing dysmenorrhoea, a lump in the abdomen causing distension and pain, and chest ventral spine pain, hot numbness pain, sore swells and ache, dysphoria and insomnia.For sternal rib hypochondriac pain, arthralgia due to wind-dampness, abdominal mass lumps, and sore swells and ache, fall fall forward grieved, irregular menstruation, through closing dysmenorrhoea, postpartum stasis of blood pain etc.Treatment sternal rib pain, abdominal mass caking, and irregular menstruation, through amenorrhoea pain, there is good effect." detailed outline " carries: the red sage root, and by " the sensible opinion of married woman " cloud, gynecopathy controlled by Siwu Tang, pays no attention to antenatal postpartum, how many through water, all can be general, and the only taste red sage root falls apart, and cures mainly identical with it.The lid red sage root can break place blood, mends new blood, peaceful tire, and fall stillborn foetus, only metrorrhagia stagnant under, menstruation regulating arteries and veins.Main Compositions of Radix Salviae Miltiorrhizae tanshinone has hemangiectasis, improves circulation, removes the effects such as intravascular coagulation, has effect of invigorating blood circulation trace, and can promote that liver blood circulates, be beneficial to liver cell regeneration.
The pungent micro-hardship of rhizoma cyperi is sweet, and flat function cures mainly: regulate the flow of vital energy Xie Yu, menstruction regulating and pain relieving.For stagnation of QI due to depression of the liver, chest, the side of body, abdominal distention, indigestion, irregular menstruation, through closing dysmenorrhoea, cold hernia stomachache, swollen breasts." detailed outline " carries it: time loose, gas is trembled with fear epidemic disease, and profit three is burnt, Xie Liuyu, and the diet that disappears gathers, and phlegm and retained fluid ruffian is full, and instep swells, abdominal distension, beriberi, only trusted subordinate, limbs, head, order, tooth, all pains of ear, ulcer sores, spits blood, lower blood, hematuria, under married woman's uterine bleeding band, the moon wait uncomfortable, before tire postpartum all kinds of diseases and ailments.
Root tuber of aromatic turmeric is pungent, bitter, cold.Return liver, the heart, lung channel.Function cures mainly regulating qi to disperse stagnation, heart fire-clearing upset-relieving, normalizing gallbladder to cure jaundice.For through closing dysmenorrhoea, chest and abdomen swelling and pain, shouting pain, pyreticosis coma, epilepsy is gone mad, and jaundice urine is red.Promoting qi circulation and removing obstruction in the collateral, cool blood breaks the stasis of blood.Control all pains of chest abdomen side of body rib, lose the heart demented, pyreticosis coma, spit blood, bleeding from five sense organs or subcutaneous tissue, hematuria, blood drenches, women's vicarious menstruation, jaundice." property of medicine opinion " carries it: control woman place vim and vigour pained, and cold air knot is poly-, and warm vinegar rubs and takes it.Tang Materia Medica carries it: main blood amasss, lower gas, myogenic, hemostasis, and broken extravesated blood, blood drenches, hematuria, metal-inflicted wound.
The Radix Astragali has the effects such as invigorating qi for strengthening superficies, sharp water detumescence, pus draining and toxin expelling, myogenic.The history of medicinal existing more than 2000 year so far of the Radix Astragali, modern study, the Radix Astragali is containing the various trace elements such as saponin, sucrose, polysaccharide, several amino acids, folic acid and selenium, zinc, copper.Have enhanced machine body immunity function, protect the liver, diuresis, anti-ageing, resisting stress, step-down and antibacterial action more widely.But table is real evil to be contained, retention of dampness due to stagnation of QI, and dyspepsia is stagnated, ulcer from the beginning of or the real example such as routed after heat poison Shang Sheng.The Radix Astragali has invigorating qi for strengthening superficies, diuresis holder poison, apocenosis, effect of expelling pus and promoting granulation.Weak for the deficiency of vital energy, anorexia and loose stool, the sinking of qi of middle-jiao, rushes down prolapse of the anus for a long time, uterine bleeding of having blood in stool, exterior deficiency spontaneous perspiration, and ulcer difficulty is burst, and burst for a long time and do not hold back, the deficiency of blood is sallow, and interior heat is quenched one's thirst." herbal classic " is recorded: " main ulcer, loses sore for a long time, apocenosis pain relieving.Qi-restoratives, children's's all kinds of diseases and ailments." " Japan hanako materia medica " record: " help gas to strengthen the bone, put on flesh and enrich blood.”
The dried rhizome of rehmannia: the dried rhizome of rehmannia is also radix rehmanniae recen, the fresh or dry block root of Scrophulariaceae herbaceos perennial glutinous rehmannia Rehmannia glutinosa Libosch..Heat-clearing, promote the production of body fluid, moisturize, laxation, the broken stasis of blood, raw new, pain relieving, menstruation regulating, the metal-inflicted wound stasis of blood, cool blood, hemostasis; The effect of fresh rehmannia root and radix rehmanniae recen is different.Fresh rehmannia root clearing heat and promoting fluid, can stop blooding and cool blood, be often for consumption of YIN caused by febrile disease, the illnesss such as haematemesis, abscess of throat, the deep red polydipsia of tongue, a spot dermexanthesis and nosebleed heat.Relative to fresh rehmannia root, radix rehmanniae recen is heat clearing and blood cooling, also can promote the production of body fluid, all right yin-nourishing, is used for treatment yin asthenia generating intrinsic heat, hectic fever due to yin labor heat, the deep red polydipsia of tongue, sends out the problems such as spot dermexanthesis.The dried rhizome of rehmannia is cold in nature, and function is enriching yin and nourishing kidney.Not only promote the production of body fluid to quench thirst and heat clearing and blood cooling, also have effect to metrorrhagia, irregular menstruation, fetal irritability, constipation etc., every blood system has the people of thermal burn the moon, can often take.If want to treat warm heat disease, qingying decoction can be done with the dried rhizome of rehmannia; If the later stage for the treatment of warm disease, because waste heat does not also disappear to the greatest extent, the dried rhizome of rehmannia should be used for boiling Qinghao Biejia Tang; In addition, contain for blood-head poison, macula purple is black, and the serious heat of warm heat disease enters the symptom of ying blood, can take the Sisheng Wan that the dried rhizome of rehmannia is made; General want nourishing Yin and promoting production of body fluid to treat interior heat quenches one's thirst with constipation, the once liquid soup that the dried rhizome of rehmannia boils should be eaten.
The root bark of white mulberry is the root skin of moraceae plants mulberry Morus alba L..Main product in Anhui, Henan, Zhejiang, Jiangsu, the ground such as Hunan.Effect: removing heat from lung and relieving asthma, inducing diuresis for removing edema.Cough for lung heat and breathe heavily, the edema of the face, the diseases such as difficult urination." property of medicine opinion ": make, flat.Can control lung qi breathes heavily full, aqueous vapor edema, and main wound is exhausted, dredging water passages, and disappear aqueous vapor, the headache of consumptive disease visitor heat, interior tonifying for the deficiency." Japan hanako materia medica ": temperature, in tune, lower gas.Dissolving phlegm is quenched the thirst, sharp intestine and small intestine, appetizing, lower food, and kill abdomen and hide worm, only cholera is vomited and diarrhoea.
Hawthorn is containing multivitamin, crataegolic acid, tartaric acid, citric acid, malic acid etc., and also containing the mineral matter such as flavonoids, lactone, carbohydrate, protein, fat and calcium, phosphorus, iron, contained lipolytic enzyme can promote the digestion of fat food.Promote gastric secretion and increase the functions such as stomach endoenzyme element.The traditional Chinese medical science is thought, hawthorn has the effects such as long-pendingization that disappear is stagnant, convergence stops dysentery, activate blood circulation and disperse blood clots.Cure mainly the diseases such as eating accumulation, chest diaphragm ruffian are full, the amenorrhoea of hernia blood stasis.Containing the drug ingedient such as mountain terpene and brass class in hawthorn, there is significant hemangiectasis and hypotensive effect, there is the function strengthening cardiac muscle, arrhythmia, adjusting blood lipid and cholesterol level, hawthorn has the effect activated blood circulation and dispersed blood clots, contribute to removing local extravasated blood state, have auxiliary curative effect to traumatic injury; Flavonoids contained by hawthorn and the substance such as vitamin C, carrotene block and reduce the generation of free radical, can strengthen the immunity of body, have anti-aging, anticancer effect; Having in hawthorn relievings asthma reduces phlegm, the composition of anti-bacteria, treatment abdominal pain diarrhea.
Fructus Corni, cure mainly perverse trend fever and chills under the heart, Wen Zhong, by cold temperature numbness, goes three worms, for a long time clothes made light of one's life by commiting suicide reinforcing yin essence benefit essence, five viscera settling, logical nine orifices, stop the merit of dribbling urination; Take improving eyesight, brute force for a long time all the year round.Fructus Corni, have another name called cornus officinalis sieb et zucc, medicine jujube, real jujube, fructus corni, meat jujube etc., for China commonly uses rare traditional Chinese medicine, applicating history is long.It is gentle with its benefit power, establishing-Yang and do not help fire, enriching yin and oiliness diaphragm, convergence and do not stay evil wait special efficacy like by successive dynasties medical science use.Zhang Zhongjing is that monarch has formulated " chinkuei shin chewan pills " with Fructus Corni.According to chemical analysis, Fructus Corni contains the active ingredients such as the stronger cornin of physiologically active, tartaric acid, gallic acid, malic acid, resin, tannin and multivitamin, having and strengthen immunity, anti-inflammatory, the pharmacological action such as antibacterial, is the medicine simply commonly used in tcm clinical practice.
Purslane herb hyoscine, has clearing heat and promoting diuresis, removing toxicity for detumescence, anti-inflammatory, quenches the thirst, diuresis; Seed improving eyesight.Modern study, purslane is also containing abundant SL3 aliphatic acid and vitamin A sample material: SL3 aliphatic acid forms cell membrane, especially brain cell membrane and the necessary material of eye cell membrane; Vitamin A sample substance maintains epithelial tissue as skin, cornea and conjunctival normal function, participates in the synthesis of visual purple, strengthens retinal photoreceptor performance, also participates in many oxidizing process in body.In addition, purslane also can make veterinary drug and agricultural chemicals; Young stem and leaf can do vegetables etc.Purslane acid is cold, enters the heart channel of Hang-Shaoyin and walks blood system, function cooling blood and hemostasis, and carbuncle is treated in removing toxic substances; Enter large intestine again kind refrigerant blood control dysentery.By bloody flux, sore are commonly used.Purslane has effect of removing toxic substances, anti-inflammatory, diuresis, detumescence.Certain auxiliary therapeutic action is had to diabetes.Purslane contains 2.3 grams, protein, 0.5 gram, fat, 3 grams, carbohydrate, calcium 85 milligrams, 56 milligrams, phosphorus, iron 1.5 milligrams and potassium, manganese, copper, magnesium, zinc etc. in every 100 grams of cauline leafs.Also containing carrotene 2.23 milligrams, Catergen 3 milligrams, vitaminB10 .03 milligram, vitamin B2 0.11 milligram, 0.7 milligram, nicotinic acid, citric acid and several amino acids.Purslane is edible with young stem and leaf.Also shine after can completing and make dry vegetalbe.Purslane complete stool be used as medicine there is removing toxic substances, that inhibiting bacteria and diminishing inflammation, diuresis stop dysentery, ease constipation disappears is stagnant, debug, the drug effect such as improving eyesight and suppression uterine hemorrhage; External application can control the disease such as erysipelas, venomous snake bite.
Cogongrass rhizome cures mainly: cooling blood and hemostasis, clearing heat and detoxicating.For spitting blood, hematuria, heat is drenched, oedema, jaundice, difficult urination, pyreticosis polydipsia, and stomach energy is vomitted the sound of vomiting, coughs." herbal classic ": " main internal lesion caused by overexertion void is thin, tonifying middle-Jiao and Qi, except hemostasis, blood close fever and chills, diuresis." " not Lu ": " lower five drenches, and except visitor's heat is at stomach, quenches the thirst, hard muscle, married woman's metrorrhagia.", " book on Chinese herbal medicine justice ": cogongrass rhizome, cold and cool and taste is very sweet, the heat that to purify the blood point, and do not hinder drying, not sticky again, therefore cool blood and do not consider its long-pending stasis of blood, tell nosebleed spitting blood to lead.Drop-down fire is inverse, and its effect is very prompt, therefore main stomach fire hiccup vomiting again, the lung heat circulation of vital energy in the wrong direction is breathed heavily full.And sweet cold and greasiness liquid, though fall inverse and differ from bitter dry, then slake thirst and help produce saliva again, and wash clearly the latent heat between lung stomach and intestine, can the paddy that disappears be treated yearningly dry.Again can treating stranguria closing and control blood under haematuria, and housewife female's blood-heat bleeding, metrorrhagia drenches band.The little water of tonneau again, the oedema of the knot that expels the heat-evil, leads the jaundice of stagnant heat, all sweet cold actual effect of removing heat by catharsis.So its sweet cold power, let out clearly lung stomach, especially have speciality, all dentalgia gums swell, all sores of noma dispute, and the strongly fragrant pharyngalgia of stopping up of lung heat is rotted all cards, and make in order to assistant, effect is the most outstanding, and without abuses.
The root bark of Chinese wolf-berry is cold in nature, and taste is sweet.Cool blood is except steaming, and fire falls in clearing lung-heat.For deficiency of Yin hectic fever, hectic fever due to yin night sweat, cough with lung heat, spitting of blood, bleeding from five sense organs or subcutaneous tissue." not Lu ": " main air wets, lower breast side of body gas, the headache of visitor's heat, mends internal injury great Lao and to hiss suction, hard muscle, reinforcing yin essence, sharp intestine and small intestine, resistance to cold and heat.″
Flower of hyacinth dolichos Latin plant animal mineral name: Dolichos lablab L. returns through spleen; Stomach; Large intestine channel.Medicinal material Ji Yuan: be the flower of legume French beans.Nature and flavor: flat; Sweet light; Nontoxic.Gui Jing: spleen; Stomach; Large intestine channel function cures mainly: expelling summer-heat and damp, and middle invigorating the spleen.The main summer hinders summer-heat and damp, heating, have loose bowels, dysentery, leukorrhea with reddish discharge, fall injure swollen.Flower of hyacinth dolichos contains former anthocyanin (proanthocyanidins), flavonoids (flavonoids), anthocyanidin (anthocyanidins), coumarin (conmarins)." book on Chinese herbal medicine is just read ": flower of hyacinth dolichos red person enter blood system and declare the stasis of blood, white person enters gas and divides and promoting the circulation of qi, and all flowers are all loose, therefore can fall apart evil by heat clearly, lets out the cards such as dysentery also to control Xia Yue
Motherwort taste is arduous, cool.Invigorate blood circulation, silt of dispelling, menstruation regulating, disappear water.Treatment menoxenia, threatened abortion is had difficult labour, placenta retension, postpartum anemic fainting, abdominal pain due to blood stasis, and metrorrhagia and metrostaxis, rushes down blood at hematuria, and carbuncle swells sore.Motherwort containing the material such as leonurine, fumaric acid, has the effects such as promoting blood circulation for regulating menstruation, hypotensive, inducing diuresis to reduce edema.
Specific embodiment 1:
First prepared by bitter buckwheat, stir-fry.
Again by all the other raw material purslanes, flower of hyacinth dolichos, the dried rhizome of rehmannia, the root bark of Chinese wolf-berry, cogongrass rhizome, Poria cocos, the red sage root, lotus leaf, eupatorium, gynostemma pentaphylla, the root bark of white mulberry, Fructus Corni, root tuber of aromatic turmeric, rhizoma cyperi, the Radix Astragali, heart of a lotus seed benevolence, the bighead atractylodes rhizome, hawthorn, motherwort is extracted to concentrate and makes granule, pulvis or paste.
Mix the extract of bitter buckwheat and other raw materials fried, ultraviolet radiation for sterilizing and disinfecting packs, and directly can take after mixing it with hot water during use.
Specific embodiment 2:
Get bitter buckwheat 5000g to clean, the airing time, at 7-12 hour, parches; Bitter buckwheat good for airing is put into the pot that completes and goes green grass or young crops, complete 20-30 minute at 70-100 DEG C, then puts into large iron pan and stir-fry, and on first backward downwards, firmly wants evenly, when buckwheat color starts jaundice, start little fire stir-fry 10-15 minute shaping; Naturally dry after taking out; By surplus stock purslane 1500g, flower of hyacinth dolichos 1500g, dried rhizome of rehmannia 1500g, root bark of Chinese wolf-berry 1500g, cogongrass rhizome 1500g, Poria cocos 1500g, red sage root 1500g, lotus leaf 1500g, eupatorium 1500g, gynostemma pentaphylla 1500g, root bark of white mulberry 1500g, Fructus Corni 1500g, root tuber of aromatic turmeric 1500g, rhizoma cyperi 1500g, Radix Astragali 1500g, heart of a lotus seed benevolence 1500g, bighead atractylodes rhizome 1500g, hawthorn 1500g, motherwort 1500g cleans impurity elimination, dry, be ground into particle, soak 1 hour; Soaked bulk drug is put boiling secondary in multi-function extractor; Add up the water of medicinal material 10 times amount for the first time, decoct 1.5 ~ 2 hours, get decocting liquid, filter; Second time adds up the water of medicinal material 7 times amount, decocts 1 ~ 1.2 hour, gets twice decocting liquid mixing, filters; The filtrate of filtration inserted in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C, relative density is the concentrate of 1.05, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Refrigeration liquid is added the filter aid diatomite of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 1g crude drug amount, adds dextrin and make granule.Again the bitter buckwheat fried is mixed with the granule made, ultraviolet disinfection, pack and get final product.
Specific embodiment 3:
Cleaned by bitter for raw material buckwheat 3500g, the airing time, at 7-12 hour, parches; Bitter buckwheat good for airing is put into the pot that completes and goes green grass or young crops, complete 20-30 minute at 70-100 DEG C, then puts into large iron pan and stir-fry, and on first backward downwards, firmly wants evenly, when buckwheat color starts jaundice, start little fire stir-fry 10-15 minute shaping; Naturally dry, then by surplus stock purslane 1500g, flower of hyacinth dolichos 1600g, dried rhizome of rehmannia 1600g after taking out, root bark of Chinese wolf-berry 1500g, cogongrass rhizome 1500g, Poria cocos 1600g, red sage root 1600g, lotus leaf 1500g, eupatorium 1500g, gynostemma pentaphylla 1600g, root bark of white mulberry 1500g, Fructus Corni 1500g, root tuber of aromatic turmeric 1600g, rhizoma cyperi 1500g, Radix Astragali 1600g, heart of a lotus seed benevolence 1600g, bighead atractylodes rhizome 1500g, hawthorn 1500g, motherwort 1500g put it in 10 times of water gagings and soak.Drop into multi-function extractor and extract twice, first time adds 8-10 times amount soak by water 1-2 hour, and second time adds 4-8 times amount soak by water 1-2 hour, merges twice decocting liquid, filters to get filtrate; Heating is concentrated into pasty state, and then put into baking oven inner drying powdered, bitter buckwheat good with frying after ultraviolet radiation for sterilizing and disinfecting is hybrid packed, and during use, direct boiling water is taken after mixing it with water.
Pharmacological toxicity is tested
Experimental example 1: acute toxicity test of the present invention
One, test material: animal: Kunming mouse, body weight 18-25g, male and female half and half, Shandong University's biology laboratory breeding.Medicine: the present invention's (all raw material mixing decoction 2 times merges and filters, taking liquid) is containing 0.0365mg/ml.
Two, method:
1, LD50 calculates: adopt improvement karber's method, mouse is divided into 5 groups at random, often organize 10, male and female half and half, dissolve adding distil water of the present invention, are made into Cmax, by the administration of mouse maximum permission capacity, institute is followed successively by 18,14.4 to dosage by crude drug amount, 11.5,9.2,7.4 (g.kg-1), in animal fasting (can't help water) after 18 hours, administration at twice in one day (interval half an hour), each 0.5ml, observes animal dead situation.
2, maximum tolerated dose measures (MTD value): get mouse 20, each 10 of male and female.Adding distil water of the present invention is dissolved, is made into maximum concentration, by the maximal tolerance dose of animal, feed device and can twitch to inject to fill with and be as the criterion.In animal fasting (can't help water) after 18 hours, administration at twice in one day (interval half an hour), each 0.5ml (every ml containing crude drug 0.36g), total dose is 18g crude drug/kg.d, 300 times of quite clinical adult 50Kg body weight consumption.Continuous Observation 7 days after administration.
Three, result of the test:
In LD50 calculates when giving mouse with maximum acceptable concentration and maximum permission capacity (18g/Kg.d), have no dead mouse, namely LD50 is not measured, ask maximum tolerated dose only, in 7 day observation period, its appetite of animal, activity, hair color, the state of mind etc. are all normal, grow normal, there are no death.Namely select the 300 times of doses being equivalent to clinical dosage, and have no adverse reaction, show that acute toxicity is minimum, MTD>18g/Kg.d.
Experimental example 2: the result of the test of acute toxicity and long term toxicity
Acute toxicity test: give the present invention by the disposable gavage of small white mouse, maximum concentration 35%, maximum gavage capacity 0.4ml/10g, dosage 14g/kg (every g medicinal powder is equivalent to 10g crude drug), Continuous Observation 7 days, do not find any toxic reaction, because concentration and dosage cannot increase, therefore fail to measure the LD50 of this medicine.Maximum tolerance determination: with maximum concentration, maximum gavage capacity, mice lavage administration 3 times, 5 hours, interval, then Continuous Observation 7 days, none example is dead.Medicinal powder dosage is >42g/kg. day (every g medicinal powder is equivalent to 10g crude drug), calculates 420 times of the clinical consumption per day that is equivalent to be grown up by kg body weight.
Long term toxicity test: whether produce toxic reaction for observing long-term prescription, give rat the present invention respectively and raise clothes, by adult 70 times of clinical consumption per day and 35 times (i.e. 7g/kg/ day and 3.5g/kg/ day), give continuously and feed 8 weeks, have no the behavior of rat, feed, body weight appearance extremely, with control group ratio, routine blood test, hepatic and renal function, the change all without exception of various important organ, within the scope of institute's dosage, do not find any toxicity of the present invention.Confirmed by the acute and chronic toxicity test of animal, safe range of the present invention is comparatively large, is a kind of safe and reliable defaecation product.
Pharmacological experiment:
1 materials and methods
1.1 materials and instrument
Experimental rat feeds high lipid food standard formula full price mouse feed 60%, lard 12%, sucrose 5%, milk powder 5%, peanut 5%, egg 10%, sesame oil 1%, salt 2% used, is processed by Animal Science Co., Ltd of University Of Qingdao; Other agents useful for same are that commercially available analysis is pure; The firelight or sunlight biological Co., Ltd of T-CHOL detection kit, triglycerides detection kit and HDL detection kit wound; The male SD rat 100 of firm ablactation is only provided by University Of Qingdao's Experimental Animal Center, raises in this school SPF level animal experimental center that [temperature (24 ± 2) DEG C, relative humidity is 50%.Satrorius company of BP211D type electronic analytical balance Germany; 202 type Constant Temp. Oven Shanghai Suo Pu Instrument Ltd.; Sigma company of 1-15PK small desk refrigerated centrifuge Germany; TU-1800S ultraviolet-uisible spectrophotometer Beijing Puxi General Instrument Co., Ltd; PUZS-300 full automatic biochemical apparatus Nanjing Pu Lang medical equipment Co., Ltd; Stainless steel rat metabolism cage Beijing good Asource industry Science and Technology Ltd.; SOX406 Milko-Tester Jinan Hanon Instruments Ltd..
1.2 tea of the present invention feed the impact of rat body weight increase to high fat
1.2.1 animal used as test and the grouping growth male Wistar rat of 3 months, body weight (210 ± 15) g, sum 50, thered is provided by University Of Qingdao's Experimental Animal Center, raise in this school SPF level animal experimental center (temperature (24 ± 2) DEG C, relative humidity is 50%).Be divided into 5 groups at random by body weight, often organize 10.Animal grouping is as follows with administrations:
Blank group (Blank): gavage etc. hold physiological saline, continuous 9 weeks; Bitter buckwheat extract group (A): 400mg/kg/d, continuous gavage 9 weeks; All the other raw material extract group (B): 400mg/kg/d, continuous gavage 9 weeks; Low dose group of the present invention (C): 400mg/kg/d, continuous gavage 9 weeks; High dose group of the present invention (D): 800mg/kg/d, continuous gavage 9 weeks.
1.2.2 the original body mass of observation index and detection method precise rat, is distributed into cage, 1, every cage, ensures the abundant supply of water and food, measures weekly the intake of food and water, measure increased weight weekly simultaneously.1st week and the 9th week timing eye socket get blood 0.5mL, and immediately in 2500r/min refrigerated centrifuge 2min, automatic clinical chemistry analyzer detects total sterol, high-density protein and content of triglyceride in serum.
The impact that 1.3 constipation-relieving teas of the present invention are lost weight on obese rat
1.3.1 Diet-induced obesity rat molding method 10 is standard full price mouse forage feed, feeds for 90 with high lipid food.Feed after 3 months, exceed chow diet with body weight and feed 20% of rat body weight mean value for obesity standard, modeling success 49, success rate is 54.4%.
1.3.2 grouping and the successful obese rat of processing method modeling change to the nursing of standard complete feed subsequently, are divided into 5 groups at random by body weight, often organize 9.Blank group (Blank): model comparison rat, gavage equal solvent physiological saline, continuous 4 weeks; Bitter buckwheat extract group (A): 400mg/kg/d, gavage treatment 4 weeks; All the other raw material group extract group (B): 400mg/kg/d, gavage treatment 4 weeks; Low dose group of the present invention (C): 400mg/kg/d, gavage treatment 4 weeks; High dose group of the present invention (D): 800mg/kg/d, gavage treatment 4 weeks.
1.3.3 observation index and detection method weigh body weight before and after treatment with electronic scale, and calculate body weight decrement before and after administration, before accounting for administration using body weight decrement, the percentage of body weight is as weight-loss ratio.Experiment terminates the previous day, gets blood 2mL to rat eye socket, and immediately in 2500r/min refrigerated centrifuge 2min, automatic clinical chemistry analyzer detects total sterol, high density lipoprotein level bletilla content of triglyceride in serum.Experiment terminates rear executions rat, to get under omoplate fatty (brown fat) after item and weighs; Get all Abdominal Wall Fats of kidney and epididymal adipose tissues (white adipose), represent visceral fat mass with both sums; Calculate fat-body anharmonic ratio after interior fat weight ratio and item simultaneously.
1.4 data statistic analysis
Data statistic analysis is carried out with SPSS100 software.
2 results and analysis
2.1 the present invention feeds the fat-reducing effect to obese rat
In whole experimentation, each test group of animals is without obviously taking bad reaction, and specific experiment result is as shown in table 1.
After modeling success, the body weight average of obese rat is more than 630g, give active material gavage after 4 weeks, tartary buckwheat extract group, the body weight of high dose group obese rat of the present invention comparatively control group has conspicuousness to alleviate (p<0.05), all the other raw extract groups also have certain phenomenon that loses weight, but compare not obvious (p>0.05) with blank group, effect of the present invention is better than independent tartary buckwheat extract and other raw extracts (p<0.05), and present certain dose-effect relationship, high dose better effects if.
The relevant body weight parameters (n=9, X ± SD) of tested obese rat respectively organized by table 1
Note: represent there was no significant difference (p>0.05) with column data acceptance of the bid note same letter; Difference then has significant difference (p<0.05); Table 2-table 3 is same.
As shown in Table 2, compare with blank group, alone bitter buckwheat and other raw materials can reduce visceral adipose and internal organ fat body ratio (p<0.05) of obese rat, the present invention has the effect (p<0.05) obviously reducing obese rat interior fat equally, its effect is even better than bitter buckwheat group or other raw extract groups, high dose more remarkable effect of the present invention, so that the effect (p<0.05) of fat body ratio after fat and item after also showing the item significantly reducing obese rat.
The different fat sites content (n=9, X ± SD) of tested obese rat respectively organized by table 2
Table 3 result shows, give each experimental group material and all obviously can reduce obese rat serum cholesterol, triglycerides (with blank group ratio, p<0.05), and the effect of high and low dose of the present invention compares with other groups and has obvious difference (p<0.05), illustrate that high and low dose effect of the present invention is better than bitter buckwheat group or other raw extract groups (p<0.05).
The lipids contents (n=9, X ± SD) of tested obese rat respectively organized on the 4th week by table 3
Experimental result shows, the present invention all has obvious reducing effect to Mouse Weight, fat and serum triglyceride, and can improve microcirculation, and reducing weight and blood fat effect has been described.
Specific embodiment: Jiang, female, 31 years old, after having given birth to child, body weight increased suddenly, and be raised to 78 kilograms from 56 kilograms, readme is gluttonous, slight constipation.Be reluctant hungrily, can not subtract always.Trial trains down, but does not have perseverance not adhere to; Weight reduction with drugs, does not stop diarrhoea and causes health to dewater, compromised kidneys, slight apositia, or else dares to attempt weight reduction with drugs.Mood is gloomy, and complexion is very bad, and face starts to occur chloasma hepaticum butterfly macules, thinks that oneself does not have attraction, even thinks liposuction.Upon somebody's introduction, start to contact traditional Chinese medicine capable of reducing weight, and need not aviod certain food, to health without any side effect; Attempt a week, Fang Yong: bitter buckwheat 30g, purslane 12g, flower of hyacinth dolichos 13g, dried rhizome of rehmannia 15g, root bark of Chinese wolf-berry 13g, cogongrass rhizome 14g, Poria cocos 12g, red sage root 14g, lotus leaf 13g, eupatorium 14g, gynostemma pentaphylla 13g, root bark of white mulberry 12g, Fructus Corni 13g, root tuber of aromatic turmeric 12g, rhizoma cyperi 13g, Radix Astragali 13g, heart of a lotus seed benevolence 13g, bighead atractylodes rhizome 13g, hawthorn 15g, motherwort 13g, every day works as tea-drinking, and every day two wraps, think that hunger was unlike in the past in abdomen, eat and as many in the past, but how sensation does not become fat, constipation improvement.First week has even subtracted 3 jin, is very glad, because do not aviod certain food completely.Second week, moderate reduction diet, coordinates bitter buckwheat slim tea, adheres to motion 1 hour every day, finds to have subtracted again 5 jin, starts the effect believing bitter buckwheat slim tea; Adhere to use one month, subtracted 15 jin, facial colour spot starts thin out, and skin complexion starts to improve; Adhere to using second month, find that the potbelly of oneself starts to flatten, thin 15 jin, and there is no apocleisis completely, dehydration, diarrhoea phenomenon, constipation is completely good.Recover stature, and not specially fasting.Feel good, still adhere to bag every day one now, work as tea-drinking.

Claims (3)

1. a bitter buckwheat Weight-reducing and lipid-lowering constipation-relieving tea, it is characterized in that, described bitter buckwheat Weight-reducing and lipid-lowering constipation-relieving tea is made up of the bulk drug of following parts by weight: bitter buckwheat 10 ~ 50 parts, purslane 10 ~ 20 parts, flower of hyacinth dolichos 10 ~ 20 parts, 10 ~ 20 parts, the dried rhizome of rehmannia, the root bark of Chinese wolf-berry 10 ~ 20 parts, cogongrass rhizome 10 ~ 20 parts, 10 ~ 20 parts, Poria cocos, the red sage root 10 ~ 20 parts, 10 ~ 20 parts, lotus leaf, eupatorium 10 ~ 20 parts, gynostemma pentaphylla 10 ~ 20 parts, the root bark of white mulberry 10 ~ 20 parts, Fructus Corni 10 ~ 20 parts, root tuber of aromatic turmeric 10 ~ 20 parts, rhizoma cyperi 10 ~ 20 parts, the Radix Astragali 10 ~ 20 parts, heart of a lotus seed benevolence 10 ~ 20 parts, the bighead atractylodes rhizome 10 ~ 20 parts, hawthorn 10 ~ 20 parts, motherwort 10 ~ 20 parts.
2. bitter buckwheat Weight-reducing and lipid-lowering constipation-relieving tea according to claim 1, it is characterized in that, described bitter buckwheat Weight-reducing and lipid-lowering constipation-relieving tea is made up of the bulk drug of following parts by weight: bitter buckwheat 10 ~ 30 parts, purslane 10 ~ 15 parts, flower of hyacinth dolichos 10 ~ 15 parts, 10 ~ 15 parts, the dried rhizome of rehmannia, the root bark of Chinese wolf-berry 10 ~ 15 parts, cogongrass rhizome 10 ~ 15 parts, 10 ~ 15 parts, Poria cocos, the red sage root 10 ~ 15 parts, 10 ~ 15 parts, lotus leaf, eupatorium 10 ~ 15 parts, gynostemma pentaphylla 10 ~ 20 parts, the root bark of white mulberry 10 ~ 20 parts, Fructus Corni 10 ~ 20 parts, root tuber of aromatic turmeric 10 ~ 20 parts, rhizoma cyperi 10 ~ 20 parts, the Radix Astragali 10 ~ 20 parts, heart of a lotus seed benevolence 10 ~ 20 parts, the bighead atractylodes rhizome 10 ~ 20 parts, hawthorn 10 ~ 20 parts, motherwort 10 ~ 20 parts.
3. bitter buckwheat Weight-reducing and lipid-lowering constipation-relieving tea according to claim 1, it is characterized in that, described bitter buckwheat Weight-reducing and lipid-lowering constipation-relieving tea is made up of the bulk drug of following parts by weight: bitter buckwheat 10 ~ 30 parts, purslane 10 ~ 20 parts, flower of hyacinth dolichos 10 ~ 20 parts, 10 ~ 20 parts, the dried rhizome of rehmannia, the root bark of Chinese wolf-berry 10 ~ 20 parts, cogongrass rhizome 10 ~ 20 parts, 10 ~ 20 parts, Poria cocos, the red sage root 10 ~ 20 parts, 10 ~ 20 parts, lotus leaf, eupatorium 10 ~ 20 parts, gynostemma pentaphylla 10 ~ 15 parts, the root bark of white mulberry 10 ~ 15 parts, Fructus Corni 10 ~ 15 parts, root tuber of aromatic turmeric 10 ~ 15 parts, rhizoma cyperi 10 ~ 15 parts, the Radix Astragali 10 ~ 15 parts, heart of a lotus seed benevolence 10 ~ 15 parts, the bighead atractylodes rhizome 10 ~ 15 parts, hawthorn 10 ~ 15 parts, motherwort 10 ~ 15 parts.
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