CN105166930A

CN105166930A - Rheum officinale oral liquid for losing weight and reducing fat and preparing method of rheum officinale oral liquid

Info

Publication number: CN105166930A
Application number: CN201510658008.1A
Authority: CN
Inventors: 赵玉妹
Original assignee: Qingdao Hengbo Instrument Co Ltd
Current assignee: Qingdao Hengbo Instrument Co Ltd
Priority date: 2015-10-12
Filing date: 2015-10-12
Publication date: 2015-12-23

Abstract

Rheum officinale oral liquid for losing weight and reducing fat is prepared from, by weight, 10-50 parts of rheum officinale, 10-20 parts of tartary buckwheat, 10-20 parts of rhizome of rehmannia, 10-20 parts of semen plantaginis, 10-20 parts of hawthorns, 10-20 parts of purslane, 10-20 parts of lotus leaves, 10-20 parts of yoyumin, 10-20 parts of gynostemma pentaphyllum, 10-20 parts of dogwood, 10-20 parts of jasmine, 10-20 parts of rhizome cyperi, 10-20 parts of semen raphani, 10-20 parts of pericarpium citri reticulatae, 10-20 parts of immature bitter oranges, 10-20 parts of bighead atractylodes rhizome, 10-20 parts of purple perilla, 10-20 parts of endothelium corneum gigeriae galli and 10-20 parts of hyacinth bean flowers. The rheum officinale is common traditional Chinese medicine and has the effects of purging heat and promoting the intestines, removing pattogenic heat from the blood and toxic materials from the body, dispelling stagnation and promoting menstruation. The traditional Chinese medicine materials which can promote the blood circulation to remove the blood stasis and have the obvious reducing effect on fat and serum triglyceride are added, the taste is improved, and the effects of reducing the fat for losing weight and losing weight to reduce fat are well achieved.

Description

Rheum officinale oral liquid of a kind of Weight-reducing and lipid-lowering and preparation method thereof

Technical field

The present invention relates to the slimming health product containing deriving from plant composition, particularly a kind of rheum officinale oral liquid for Weight-reducing and lipid-lowering and preparation method thereof.

Background technology

Day by day flourishing due to economy, the continuous lifting of modern's living standard, cause people too much have deep love for enjoy, do not notice that the life style of oneself, behavioural habits, diet are had a liking for, thus the disease caused.Society with fast rhythm lives, the operating pressure of keen competition, serious threat is caused to the physical and mental health of modern, people more than half is made to be in sub-health state, show as: dizzy, nervous, weak, poor appetite, failure of memory, insomnia, indifferent to etc. to thing, in addition, long-term diet is unreasonable, that is: smart grain replaces coarse food grain completely, a large amount of three height (high heat, high protein, higher fatty acid), more than three, (anticorrisive agent is many, flavoring agent is many, hormone is many) agricultural chemicals residual in the absorption of food and food, chemical fertilizer stockpiling in vivo, add air, pollution of waterhead and amount of exercise less than normal, go down to make three high disease (hypertension for a long time like this, hyperglycaemia, high fat of blood), cardiovascular and cerebrovascular disease, cancers etc. so-called " modern civilization diseases " rise rapidly, and constantly rejuvenation, the serious health and lives jeopardizing the mankind.

Social change rapidly and the continuous renewal of life style, expedited the emergence of the serious advanced old and feeble of people's physiological age, wherein city white collar more so.In the booming income crowd in 35-50 year, " biological age " overage trend is obviously accelerated, and generally exceeds actual age about 10 years old.If namely actual age only has 40 years old, and physiological age has had 50 years old.In the face of so general phenomenon, someone jokes and is referred to as " generation that speed is rotten ".

Along with industrialized development, the change of dietary structure, the improvement of living condition, the quantity of Overweight and obesity crowd worldwide increases rapidly, and in the trend of becoming younger, become global and have a strong impact on healthy epidemic disease, therefore, the effective method of weight-reducing of search of health has very real significance, and anti-obesity activity material is the key that people expect to solve problem of obesity always safely and effectively.Weight-reducing and lipid-lowering method is a lot, has dietetic treatment, kinesiatrics, medicinal treatment and clinical treatment etc. and these methods more or less have weak point, and what have also easily causes side effect, as diarrhoea, apocleisis etc.And the fat-reducing of defaecation articles for use has easy to use, have no side effect, the features such as effect is remarkable, and extremely consumers.

The high speed development of Modern Urban Living, also brings a series of rich man's disease.Wherein " three is high " and obesity are the primary enemies of puzzlement people." three high diseases " refers to hypertension, hyperglycaemia (diabetes) and hyperlipemia.Usually along with obesity.They be modern society derive from " rich man's disease ", possible individualism, also may be interrelated.As: diabetes patient is easy to suffer from hypertension or hyperlipemia simultaneously, and high fat of blood is the principal element of artery sclerosis formation and development, and arteriosclerotic's blood vessel elasticity difference aggravation blood pressure raises, so the later stage all defines " three high diseases ".Be what has statistics about three height, in the Chinese ten large causes of death, the death rate relevant to metabolic disease is just up to 35.7%, and the death toll relevant to " three is high " also accounts for 27% of total death toll.High fat of blood can cause blood vessel embolism; Hypertension can cause cerebral hemorrhage and rupture of blood vessel in brain; Hyperglycaemia can cause diabetes.The World Health Organization once clearly proposed, and prevented the first line of defence of cardiovascular disease from reducing " three is high " exactly and controlling " three is high ".A lot of diabetes patient is with hyperlipidemia, and therefore diabetes and hyperlipidemia, people call that sister is sick usually, and think that high fat of blood is the secondary disease of diabetes.The diabetic of about 40% has disorders of lipid metabolism according to statistics.Be characterized in that triglycerides increases to reduce with HDL.When the reason that diabetes cause blood fat to increase is due to diabetes patient's insufficient insulin, body lactonase activity lowers, and therefore easily blood fat increases.Diabetes itself also accompany fat, protein and water, dielectric disorder except carbohydrate metabolism disturbance simultaneously on the other hand.Often there is free fatty to mobilize out from fat depot, triglycerides and FFA concentrations in blood are increased.Diabetes B people takes food too much on the one hand again, and motion is few, and impel lipid synthesis in body to increase, this is also the reason causing blood fat to increase.And fat companion's high fat of blood person, because insulin receptor number reduces relatively, thus produce insulin resistance, easy induced Diabetic.Blood fat increased perosn also easily causes the heart, cerebrovascular complication.

Rheum officinale is being collectively referred to as of the perennial plant of multiple polygonaceae Rheum, is also the title of Chinese medicine.In the document of CHINESE REGION, the todaiwo,rhizoma often that " rheum officinale " refers to.In China, rheum officinale is mainly done medicinal, but in Europe and the Middle East, their rheum officinale often refers to the Rheum kind that other several work is edible, and stem is red, gas delicate fragrance, bitter and micro-puckery, and that chews sticks to one's teeth, and has sand feeling.Autumn Mo in the cauline leaf withered or secondary spring excavates before germinateing.Removing radicula, scrapes off crust, valve cutting or section, and rope wears bunchiness drying or convection drying.Chinese herb rhubarb has attacks stagnant, clearing away damp-heat, purging intense heat, cool blood, effect such as the stasis of blood, removing toxic substances of dispelling.

The main component in rheum officinale with catharsis effect is anthraquinone glycoside and dianthracene ketone glucoside, its discharge function act as by force compared with its corresponding glucoside unit. and anthraquinone glycoside has: Chrysophanol-1-glycoside (Chrysophanol-1-monoglucoside) or chrysophan (Chrysophaein), archen-6-glycoside (Emodin--6-monoglucoside), aloe-emodin-8-glycoside (Aloe-emodin-8-monoglucoside), Physcion glycoside (Physcionmonoglucoside), Rhein-8-glycoside (Rhein-8-monoglucoside), also containing the two glycoside (Emodindiglucosi-de) of archen, aloe-emodin two glycoside (Aloe-emodindiglucosi-de), chrysophanol diglucoside (Chrysophanoldiglucoside) in sorrel.Dianthracene ketone glucoside has Sennoside A, B, C, D, E, F (SennosideA, B, C, D, E, F). and the causing of rheum officinale is rushed down effect and is directly proportional to associativity Rhein Content wherein, free anthraquinone component is without catharsis effect. and the discharge function of Sennosides comparatively anthraquinone glycoside be by force, but content is then few far beyond the latter.

Sequestered Anthraquinones mainly contains: Chrysophanol (Chrysophanol), archen (Emodin), Physcion (Physcion), aloe-emodin (Aloe-emodin), Rhein (Rhein).Rheum officinale contains rheotannic acid (Rheumtannicacids) and related substances thereof again, as gallic acid (Gallicacid), cachou extract (Cate-chin), tetrarin (Tetrarin).This type of material has anti-diarrhea effect.

In addition, rheum officinale is still containing aliphatic acid, calcium oxalate, glucose, fruit sugar and starch.Rheum officinale root-like stock contains the Anthraquinone derivatives such as Rhein, archen, Chrysophanol, aloe-emodin, Physcion, all without catharsis effect.The another glucoside containing above material and the bighead atractylodes rhizome glycosides A, B, C etc., in conjunction with shape anthraquinone derivative, all have catharsis effect.In addition still containing tannin etc.Rheum officinale root-like stock and root have clearing away heat and purging, broken amassing goes the effect such as the stasis of blood, anti-inflammation.Raw with being drastic purgative, use after concocting as slow prescribe medicine.Hemostasis is can be used for again after frying charcoal.Stomach invigorating, astriction is had when low dose is taken.Rheum officinale contains anthracene glucoside, therefore in yellow, has the effect of defaecation.Contain again the calcium oxalate of nearly 40%, therefore many grits.Other compositions also have the rheotannic acid of archen, colloid, resin, Rhein, aporetin and Bearberry Extract.

After the active ingredient of rheum officinale is oral, discharge function is played by bacterial metabolism for having bioactive metabolite in alimentary canal. also there are some researches prove: another approach that rheum officinale plays discharge function is that Sennosides is by after intestinal absorption, glucoside unit is converted into through liver, stimulate coat of the stomach neuropile again and cause intestinal peristalsis to cause and rush down, a part is transported to large intestine with prototype or glucoside unit with blood simultaneously, neuropile and more deep part muscle neuropile etc. under irritates nucous membrane, make bowel movement hyperfunction, causing under rushing down. under the rushing down of rheum officinale, composition can be drained in milk, Dress for nursing woman with after can affect nursling, cause infantile diarrhea.

Rheum officinale has double action that is excited and suppression stomach and intestine, and the former material base is Sennosides, and the material base of the latter is tannin class, and experiment shows: Rhei Decoction is hyperfunction in motion to the intestines and stomach initial stage of mouse, and the later stage is in motion suppression.Low concentration promotes, high concentration suppresses.Tannin contained in rheum officinale has inhibitory action to gastrointestinal motility, therefore can occur constipation after generation discharge function.During heavy dose of use rheum officinale (1 ~ 5g), produce discharge function; Then there is constipation in low dose of use time rheum officinale (0.05 ~ 0.3g), its mechanism is relevant with the effect that the astriction of tannin contained in rheum officinale masks composition under very few the rushing down of content.

The various health products for reducing fat sold on the market now, dragons and fishes jumbled together for medicine, the cathartic that great majority are just simple, people is allowed to dewater in a large number, cause the huge injury of the person, therefore, the effective method of weight-reducing of search of health has very real significance, and anti-obesity activity material is the key that people expect to solve problem of obesity always safely and effectively.Traditional Chinese medicine capable of reducing weight, having advantage that is nontoxic, that can be absorbed completely by organism, is the Main way that we study.Rheum officinale taste is poor, and taste not easily allows people accept.There are reducing blood lipid, antibacterial, hypoglycemic, antioxidation in present market in the urgent need to developing one, and energy interference body is to the absorption of fat, promotes the diet products that the fat taken in excretes, and has advantage that is nontoxic, that can be absorbed completely by organism.

Summary of the invention

Technical problem to be solved by this invention is, dragons and fishes jumbled together for most of Weight-reducing and lipid-lowering products in present market, and most just simple cathartic, allows people dewater in a large number, cause the illusion that body weight for humans alleviates.But can cause huge injury to the person, therefore, search of health effective Weight-reducing and lipid-lowering method has very real significance.Modern medicine study, rheum officinale is conventional Chinese medicine, has purge heat logical intestines, removing pattogenic heat from the blood and toxic material from the body, by effect that the stasis of blood is stimulated the menstrual flow.For real hot constipation, stagnant stomachache, it is not well to rush down dysentery, jaundice with damp-heat pathogen, and blood-head tells nosebleed, hot eyes, and pharynx is swollen, abdominalgia with intestinal abscess, and carbuncle swells furunculosis, hemostasis through closing, injury from falling down.Prepared RADIX ET RHIZOMA RHEI rushes down exerts oneself to delay, and rushes down scorching removing toxic substances.For pathogenic fire,toxin and furuncles.Charred RADIX ET RHIZOMA RHEI cooling blood and removing stasis stops blooding.Stasis of blood haemorrhage is had for blood-head.The present invention has catharsis, cholagogic, protects the liver, antiulcer, the effect such as antibacterial, antiviral, but rheum officinale taste is poor, and taste not easily allows people accept.The present invention adds that some are promoting blood circulation and removing blood stasis, fat and serum triglyceride is all had to the Chinese medicine of obvious reducing effect, improves mouthfeel, reach effect of lowering blood-fat and reducing weight, Weight-reducing and lipid-lowering preferably.

For solving above-mentioned technical barrier, the present invention plants the rheum officinale oral liquid of Weight-reducing and lipid-lowering, the rheum officinale oral liquid of Weight-reducing and lipid-lowering described in it can comprise the bulk drug of following weight portion: rheum officinale 10 ~ 50 parts, bitter buckwheat 10 ~ 20 parts, 10 ~ 20 parts, the dried rhizome of rehmannia, plantain seed 10 ~ 20 parts, hawthorn 10 ~ 20 parts, purslane 10 ~ 20 parts, 10 ~ 20 parts, lotus leaf, heart of a lotus seed benevolence 10 ~ 20 parts, gynostemma pentaphylla 10 ~ 20 parts, Fructus Corni 10 ~ 20 parts, cape jasmine 10 ~ 20 parts, rhizoma cyperi 10 ~ 20 parts, radish seed 10 ~ 20 parts, dried orange peel 10 ~ 20 parts, the dried immature fruit of citron orange 10 ~ 20 parts, the bighead atractylodes rhizome 10 ~ 20 parts, purple perilla 10 ~ 20 parts, the membrane of a chicken's gizzard 10 ~ 20 parts, flower of hyacinth dolichos 10 ~ 20 parts.

The rheum officinale oral liquid of described Weight-reducing and lipid-lowering, in the rheum officinale oral liquid of Weight-reducing and lipid-lowering described in it, the parts by weight of various raw material can be: rheum officinale 10 ~ 30 parts, bitter buckwheat 10 ~ 15 parts, 10 ~ 15 parts, the dried rhizome of rehmannia, plantain seed 10 ~ 15 parts, hawthorn 10 ~ 15 parts, purslane 10 ~ 15 parts, 10 ~ 15 parts, lotus leaf, heart of a lotus seed benevolence 10 ~ 15 parts, gynostemma pentaphylla 10 ~ 15 parts, Fructus Corni 10 ~ 15 parts, cape jasmine 10 ~ 20 parts, rhizoma cyperi 10 ~ 20 parts, radish seed 10 ~ 20 parts, dried orange peel 10 ~ 20 parts, the dried immature fruit of citron orange 10 ~ 20 parts, the bighead atractylodes rhizome 10 ~ 20 parts, purple perilla 10 ~ 20 parts, the membrane of a chicken's gizzard 10 ~ 20 parts, flower of hyacinth dolichos 10 ~ 20 parts.

The rheum officinale oral liquid of described Weight-reducing and lipid-lowering, the parts by weight that rheum officinale described in it leads to various raw material in the just oral liquid of losing weight also can be: rheum officinale 10 ~ 40 parts, bitter buckwheat 10 ~ 20 parts, 10 ~ 20 parts, the dried rhizome of rehmannia, plantain seed 10 ~ 20 parts, hawthorn 10 ~ 20 parts, purslane 10 ~ 20 parts, 10 ~ 20 parts, lotus leaf, heart of a lotus seed benevolence 10 ~ 20 parts, gynostemma pentaphylla 10 ~ 20 parts, Fructus Corni 10 ~ 20 parts, cape jasmine 10 ~ 15 parts, rhizoma cyperi 10 ~ 15 parts, radish seed 10 ~ 15 parts, dried orange peel 10 ~ 15 parts, the dried immature fruit of citron orange 10 ~ 15 parts, the bighead atractylodes rhizome 10 ~ 15 parts, purple perilla 10 ~ 15 parts, the membrane of a chicken's gizzard 10 ~ 15 parts, flower of hyacinth dolichos 10 ~ 15 parts.

For solving the problems of the technologies described above, the present invention also provides a kind of preparation method of rheum officinale oral liquid of described Weight-reducing and lipid-lowering, and the preparation process of the rheum officinale oral liquid of Weight-reducing and lipid-lowering described in it comprises following aspect:

A. the preparation of rheum officinale, adds alcohol extract, as component 1;

B. other raw materials described are put into ethanol to extract 2 times, as component 2;

C. again by concentrated for 2 kinds of component mixing; Bottle after sterilizing.

In described step a, rheum officinale can be excavated, removing radicula before autumn Mo, the cauline leaf withered or secondary spring germinateed, scrape off crust, valve cutting or section, rope wears bunchiness drying or convection drying, naturally dry after taking out, put into 10 times amount ethanol, soak 1-2 hour, heating extraction 2 times, each 1-2 hour, removes supernatant, merge extract, 100-120 order filters, then is the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, when ultrafiltrate reduced pressure concentration relative density is 80 DEG C 1.05 filtrate, as component 1.

In described step b, all the other bulk drugs can be put into the 10 times amount ethanol accounting for its quality, soak 1-2 hour, start to heat extraction 2 times, each 1-2 hour, remove supernatant, merge extract, filter with 100-120 order, then be the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, ultrafiltrate reduced pressure concentration is relative density when being 80 DEG C 1.05 filtrate, as component 2.

In described step c, by after above-mentioned two kinds of components mixing, can insert in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C, relative density is the concentrate of 1.25, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Refrigeration liquid is added the filter aid diatomite of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 0.1g crude drug amount, then adds dextrin, bottle after ultraviolet sterilization.

For solving the problems of the technologies described above, the present invention also provides a kind of preparation method of rheum officinale oral liquid of described Weight-reducing and lipid-lowering, and the preparation process of described rheum officinale oral liquid can also comprise the following steps:

A. rheum officinale is prepared into prepared RADIX ET RHIZOMA RHEI, extracting in water, as component 1;

B. rheum officinale is extracted rear residue to soak together with all the other bulk drugs described, extract 2 times as component 2;

C. component 1, component 2 are mixed concentrated after add honey and be in harmonious proportion, bottle after ultraviolet ray sterilization bactericidal.

In described step a, can excavate before autumn Mo, the cauline leaf withered or secondary spring germinateed, removing radicula, scrape off crust, valve cutting or section, rope wears bunchiness drying or convection drying, get the rhubarb be cut into small pieces, mix thoroughly with yellow rice wine, put in food steamer and steam, or put sealing in tank, sit in kettle, Steam by water bath is saturating, taking-up is dried, 2 ~ 3 persons are repeatedly steamed by upper method, drying and ripening rheum officinale, then dried prepared RADIX ET RHIZOMA RHEI sheet is added water, then extractor heating extraction 2 times is put into, each 1-2 hour, remove supernatant, merge extract, 100-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate reduced pressure concentration relative density is 80 DEG C 1.06 medicinal extract, as component 1, in described step b, the rheum officinale dregs of extraction can be put into together with all the other raw materials described and account for its quality 5-10 times water gaging, soak 1-2 hour, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extract, 100-120 order filters, No. 2 extracts are merged and leaves standstill, reducing pressure and being concentrated into liquor strength is 0.6g crude drug/mL, after suction filtration, when the relative density of filtrate is about 20 DEG C 1.08, be decompressed to 0.03-0.08MPa, temperature remains on 60-80 DEG C, and being concentrated into relative density is 1.20, and the medicinal extract of temperature to 60 DEG C-70 DEG C, as component 2.

In described step c, put into reduced pressure concentration tank, decompression recycling ethanol after component 1 can being mixed with component 2, being concentrated into liquor strength is 0.1g crude drug/mL, when suction filtration to the relative density of filtrate is 20 DEG C 1.06; Above-mentioned filtrate, after the large pore resin absorption column absorption that volume is 10L, with deionized water or the distilled water wash-out of 10 times of resin column volumes, then uses 95% ethanol elution of 5 times of resin column volumes, collect ethanol eluate, remove solvent, then be in harmonious proportion honey, bottle after ultraviolet ray sterilization bactericidal.

The technique effect that the present invention is useful is, the present invention has advantage that is nontoxic, that can be absorbed completely by organism.Modern medicine study, Chinese herb rhubarb has attacks stagnant, clearing away damp-heat, purging intense heat, cool blood, effect such as the stasis of blood, removing toxic substances of dispelling.Contained archen, Chrysophanol have human body relieving asthma, cholagogic, protect the liver, hypotensive effect, and have necessarily antibacterial, anti-inflammatory effect.But rheum officinale taste is poor, taste not easily allows people accept.The present invention adds that some are promoting blood circulation and removing blood stasis, fat and serum triglyceride is all had to the Chinese medicine of obvious reducing effect, improves mouthfeel, reach effect of lowering blood-fat and reducing weight, Weight-reducing and lipid-lowering preferably.Contained archen, Chrysophanol have human body relieving asthma, cholagogic, protect the liver, hypotensive effect, and have necessarily antibacterial, anti-inflammatory effect.But rheum officinale taste is poor, taste not easily allows people accept.The present invention adds that some are promoting blood circulation and removing blood stasis, fat and serum triglyceride is all had to the Chinese medicine of obvious reducing effect, improves mouthfeel, reach effect of lowering blood-fat and reducing weight, Weight-reducing and lipid-lowering preferably.

Detailed description of the invention

Rheum officinale is for want section's plant sorrel mouth, Rheum tanguticum Maxim, or the dry root and rhizome of Rheum officinale, it is a kind of herbaceos perennial, gain the name with the large look Huang of shape, Chinese herb rhubarb is famous one of the special product medicinal material and clinical conventional Chinese medicine of China, medicinal history is long, effect is unique, " legendary god of farming's draft warp " describes rheum officinale the earliest " lower extravasated blood, blood closes, fever and chills, break and gather, stay drink phlegm food, cleanse stomach, weed out the old and bring forth the new, same Li Shuigu, helping digestion in tune, peace and the five internal organs " effect, it and monkshood are classified as " good generals of troubled times " and " the good phase of times of peace and prosperity " by Zhang Jingyue, same ginseng, cultivated land nominal " four-dimension in medicine ", think " sick and as fearing, gesture Fei Yongyong Ji person, this four thing ".Rheum officinale is also international applications one of important natural drug widely simultaneously.Have 45 kinds and two subspecies at China's rheum officinale, but be loaded into " pharmacopeia " can be medicinal only have 3 kinds, i.e. genuine rhubarb, Rheum tanguticum Maxim and Rheum officinale.Rheum officinale is cold in nature, bitter, effect rushes down real heat, broken stagnant, row addiction blood, cure mainly real hot constipation, dyspepsia stagnation, stomachache, acute appendicitis, acute infectious hepatitis, blood addiction through Fujian, toothache, maggot blood, acute conjunctivitis etc., external application is controlled burn and scald, suppurative dermatosis, is incited swollen deep blue ulcer. and at present the kind awake compounds of its active ingredient is mainly concentrated on to the pharmacological research of effective rhubarb component, comprise Rhein, archen, Chrysophanol, aloe-emodin and Physcion etc.

Rheum officinale is conventional Chinese medicine, has purge heat logical intestines, removing pattogenic heat from the blood and toxic material from the body, by effect that the stasis of blood is stimulated the menstrual flow.For real hot constipation, stagnant stomachache, it is not well to rush down dysentery, jaundice with damp-heat pathogen, and blood-head tells nosebleed, hot eyes, and pharynx is swollen, abdominalgia with intestinal abscess, and carbuncle swells furunculosis, hemostasis through closing, injury from falling down.Prepared RADIX ET RHIZOMA RHEI rushes down exerts oneself to delay, and rushes down scorching removing toxic substances.For pathogenic fire,toxin and furuncles.Charred RADIX ET RHIZOMA RHEI cooling blood and removing stasis stops blooding.Stasis of blood haemorrhage is had for blood-head.Modern medicine proves, these product have catharsis, cholagogic, protect the liver, antiulcer, the effect such as antibacterial, antiviral.

Archen (emodin) is raised in archen experimental study at the mouth carrying out 2 years, archen is 280,830, in 2500ppm Stomach contents, to F344/N male rat non-carcinogenesis, F344/N female rats is likely brought out to the generation of Zymmbal gland cancer, to B6C3F1 male mice, rare renal tubule neoplasm (renaltubleneoplasms) likely occurs, but incidence is lower; Archen is under 312,625,1250ppm Stomach contents, and B6C3F1 female mice finds no the evidence of carcinogenicity.Archen can cause the incidence of male rat renal tubule transparent (renaltublehyalinedroplets) and dyeing (pigmentation) to increase, the incidence of transparent of female rats renal tubule can be caused to increase, the seriousness that male and female Rat renal tubule can be caused to dye increases, the incidence that male and female Mouse Kidney tubule can be caused to dye increases, and causes the incidence of female mice ephrosis to increase.Anthraquinone (Anthraquinone) is shown by administration in 2 years research, incidence based on renal tubule adenoma (renaltubuleadenoma), kidney and bladder animal migration epithelial cell papilloma (transitionalepithelialpapillomas) increases, and shows that anthraquinone has carcinogenicity to male F344/N rat.The generation of hepatoma is with to give anthraquinone relevant.Incidence based on renal tubule adenoma increases, and shows that anthraquinone has carcinogenicity to female F344/N rat.Bladder transitional epithelial cell papilloma or/and cancer incidence and female rats occur adenoma all with use anthraquinone relevant.Anthraquinone can increase the incidence of male and female B6C3F1 rat liver cancer to have clear evidence to show.Male may be relevant with the use of anthraquinone with the generation of the thyroid follicular cells knurl (Thyroidglandfollicularcellneoplasms) on female mice.Use anthraquinone 2 years, male and female rats kidney,liver,spleen, the infringement of marrow Non-cancerous can be caused to increase, male and female mice liver, bladder and the infringement of spleen Non-cancerous can be caused to increase, the Non-cancerous of male mice thyroid gland and kidney also can be caused to damage.Use anthraquinone can make malely to reduce with the incidence of female rats monocytic leukemia.

It is lower that rheum officinale is generally considered to toxicity, and clinical practice is safer.But overdose can cause poisoning, descend rheum officinale toxicity comparatively large especially afterwards, Nausea and vomiting, giddy, eilema, jaundice etc. can be played.Once had report, 30 experimenters take rheum officinale every day 3 times, each 3g, totally 5 days, all experimenters all produced a series of gastrointestinal reaction, and main manifestations is diarrhoea, stomachache, vomiting, nauseating, borborygmus, wherein 3 examples are because of severe diarrhea, stomachache, vomiting and be forced to lie up, and alleviate after anti symptom treatment.Once reported that 1 example took Anthraquinone laxative for a long time abroad, and caused colon to expand, the visible blackening of surgery excision colon sample, muscle layer neuronal loss, smooth muscle atrophy.Long-term taking Anthraquinone laxative also may cause cirrhosis and electrolyte disturbance (Diagnostic value).The clinical toxic and side effect of rheum officinale, except mainly causing gastrointestinal symptom, also can cause the immunosuppressive action that results of animal is consistent.Report normal person (man 12, female 11), age is from 24-66 year, point 3 groups of per mornings take rheum officinale alcohol extracting sheet 9 (every sheet is equivalent to crude drug in whole 1g) and take 7 altogether, IgA, IgG, IgM reduce before all comparatively taking medicine, leucocyte migration inhibition test reduces (P < 0.05), and C3 complement and total complement also reduce (P < 0.001), but lymphocyte transformation test is unchanged.Take IgA, IgG, IgM that 5 groups measure at d14 all to reduce (P < 0.02-0.001), C3 complement and total complement also reduce (P < 0.05), and lymphocyte transformation rate raises (P < 0.001).Take 2.5 groups to compare with taking medicine at d14: IgA, IgG, IgM all reduce (P < 0.05-0.001), C3 complement and complement also reduce (P < 0.001), and lymphocyte transformation rate rises (P < 0.05).But the change of these numerical value is all within normal range (NR), thus there is no important clinical meaning.Prompting short-term is taken relatively large rheum officinale and obviously can not be reduced immunologic function.

Lotus leaf contains multiple alkaloid and vitamin C, the polysaccharide such as nuciferine (Roemerine), miltanthin (Pronuciferine) and Nuciferine (Nuciferine).There is the effect of clearing heat and detoxicating, cool blood, hemostasis.There are the effects such as clearing summer-heat and damp, sending up the lucid yang, cooling blood and hemostasis.Modern study shows, lotus leaf also has effect for reducing blood fat, so a lot of fat-reducing, lipopenicillinase, all contain lotus leaf in product for resolving poxes.Cure mainly hot summer weather polydipsia, have a headache dizzy, oedema, the few abdominal distension of food, rush down dysentery, leukorrhea, prolapse of the anus, spit blood, bleeding from five sense organs or subcutaneous tissue, spitting of blood, has blood in stool, uterine bleeding, post partum longtime lochia, traumatic blood stasis.

Gynostemma pentaphylla finds through modern medicine study, gynostemma pentaphylla principle active component is polysaccharide, flavonoids, saponins and microelement kind, its effect mainly promotes body fat class metabolism, nutrition human body cell, there is good detoxicating, relieving inflammation effect simultaneously, be widely used in high fat of blood, fatty liver, obesity, constipation, insomnia, hepatitis B, the treatment of chronic airway inflammation (sphagitis, enterogastritis etc.) and defaecation.

The dried rhizome of rehmannia: the dried rhizome of rehmannia is also radix rehmanniae recen, the fresh or dry block root of Scrophulariaceae herbaceos perennial glutinous rehmannia RehmanniaglutinosaLibosch..Heat-clearing, promote the production of body fluid, moisturize, laxation, the broken stasis of blood, raw new, pain relieving, menstruation regulating, the metal-inflicted wound stasis of blood, cool blood, hemostasis; The effect of fresh rehmannia root and radix rehmanniae recen is different.Fresh rehmannia root clearing heat and promoting fluid, can stop blooding and cool blood, be often for consumption of YIN caused by febrile disease, the illnesss such as haematemesis, abscess of throat, the deep red polydipsia of tongue, a spot dermexanthesis and nosebleed heat.Relative to fresh rehmannia root, radix rehmanniae recen is heat clearing and blood cooling, also can promote the production of body fluid, all right yin-nourishing, is used for treatment yin asthenia generating intrinsic heat, hectic fever due to yin labor heat, the deep red polydipsia of tongue, sends out the problems such as spot dermexanthesis.The dried rhizome of rehmannia is cold in nature, and function is enriching yin and nourishing kidney.Not only promote the production of body fluid to quench thirst and heat clearing and blood cooling, also have effect to metrorrhagia, irregular menstruation, fetal irritability, constipation etc., every blood system has the people of thermal burn the moon, can often take.If want to treat warm heat disease, qingying decoction can be done with the dried rhizome of rehmannia; If the later stage for the treatment of warm disease, because waste heat does not also disappear to the greatest extent, the dried rhizome of rehmannia should be used for boiling Qinghao Biejia Tang; In addition, contain for blood-head poison, macula purple is black, and the serious heat of warm heat disease enters the symptom of ying blood, can take the Sisheng Wan that the dried rhizome of rehmannia is made; General want nourishing Yin and promoting production of body fluid to treat interior heat quenches one's thirst with constipation, the once liquid soup that the dried rhizome of rehmannia boils should be eaten.

Plantain seed this product is sweet in flavor and cold in property, enters kidney, bladder, liver, lung channel, function promoting diuresis for stranguria, excreting dampness antidiarrheal, clear liver and improve vision, clearing heat and eliminating phlegm, be medicinal herbs most in use.Li Shui, heat-clearing, improving eyesight, eliminates the phlegm.Control urinary obstruction, stranguria with turbid discharge, under band, hematuria, summer-heat and damp rushes down dysentery, cough ant phlegm, arthritis with fixed pain caused by dampness, and hot eyes is hidden from view." herbal classic ": " main gas is infirmity, pain relieving, and dredging water passages urine, except arthritis with fixed pain caused by dampness." Collective Notes to the Canon of Materia medica: " main consumptive disease.In " " not Lu ": " man wound, woman drenches drop, loss of appetite.Support lung reinforcing yin essence benefit essence.Red pain is treated in improving eyesight.": " can remove wind poison, and hepatic stroke heat, malicious wind dotting punch order, red pain is hidden from view, cerebralgia lacrimation, goes ambition dysphoria with smothery sensation.″

Dried immature fruit of citron orange relieving stagnant Qi, row phlegm, disappears long-pending.Control chest diaphragm phlegm stagnant, the feeling of stuffiness in chest, coerce swollen, dyspepsia, gas, vomit inverse, heavy after diarrhea, prolapse of the anus, the prolapse of uterus." property of medicine opinion ": control rubella all over, dislikes as numb beans in flesh and itches, main intestines wind haemorrhoids, stagnation of vital energy in the chest and abdomen, and the swollen void of two sides of body, pass diaphragm is congested." Japan hanako materia medica ": spleen benefiting and stimulating the appetite, adjust the five internal organs, lower gas, preventing or arresting vomiting is inverse, dissolving phlegm.Control gastric disorder causing nausea, cholera rushes down dysentery, helps digestion, and broken crux Xuan addiction, five types of dysphagia, except wind improving eyesight and lung qi oedema, sharp intestine and small intestine, skin is itched.Swollen can the processing of hemorrhoid is pressed.

The fruit of cape jasmine is traditional Chinese medicine, belongs to the 1st batch of medicine-food two-purpose resource that the Ministry of Public Health promulgates, has effects such as protecting liver, cholagogic, step-down, calmness, hemostasis, detumescence.The diseases such as treatment icteric hepatitis, bruise, hypertension, diabetes are usually used at tcm clinical practice.The system of cape jasmine rushes down deacetylasperulosidic acid methyl esters discharge function, and the effective dose 50 of mouse is 0.53g/kg, starts diarrhoea after taking 6 hours.Gardenoside also has catharsis effect, and the effective dose 50 of Mouse oral is 1.2g/kg, takes latter 3 hours and starts effect.The catharsis effect effective dose 50 of gardenoside is 300mg/kg, takes medicine and works for latter 3 hours.The catharsis effect effective dose 50 > 800mg/kg of geniposidic acid.

Dried orange peel regulating qi-flowing for strengthening spleen, in tune, eliminating dampness, reduces phlegm.Cure mainly abdominal fullness and distention or pain, the indigestion of the taste stagnation of the circulation of vital energy.Abdominal distension uncomfortable in chest in wet turbid resistance, indigestion and loss of appetite loose stool.The wet cough and asthma stopping up lung of phlegm.Therefore dried orange peel has three major types effect, one is lead cold-evil in the heart, two broken stagnant gas, three beneficial taste.This three large on, Main Function is row QI of the spleen and stomach.The main transmitting and distributing the fluids of taste, therefore QI of the spleen and stomach is capable, can dry, invigorating the spleen, reduce phlegm, therefore can say again, dried orange peel temperature can support spleen, pungently can be amusing, bitter can invigorating the spleen.Due to the main row QI of the spleen and stomach of dried orange peel, taste are located in middle Jiao, and the gas of middle Jiao passes through, and the gas of three Jiao is also sprung up thereupon.Three Jiao are the organ in charge of water circulation, and current water liquid, accompanies with wetting phase; Again for hiding mansion outside mansion, upper and the heart, lung, lower and liver, kidney.So the effect of dried orange peel can wide and all Zang Fu, wet throughout whole body.Say from lung, then pungent loose lung qi, hardship lets out lung qi, temperatureization cold air, can control phlegm and cough more and breathe heavily, and gas is stopped up food and stopped; Say from the heart, then pungent happy gas, hardship lets out internal heat, and warm dampness elimination is turbid, can control irritable feverish sensation in chest, and the implication sound of vomiting is smelly; Say from liver, then pungent loose liver depression, irascibility falls in hardship, warming cold-damp, so it can control liver depression heat, drink is stopped eating stagnant; Say from kidney, then pungent profit kidney is dry, and hardship is let out kidney and wet, gentle kidney qi, so it can control life fire deficiency, and indigestion.Certainly, all explanations are all relevant with spleen with wet, so its property of medicine effect performance leeway is larger, all can use in general regulating qi-flowing for eliminating phlegm side.As Li Shizhen (1518-1593 A.D.) is said: " orange peel hardship can be let out can be dry, pungent energy loose can and, it controls all kinds of diseases and ailments, always gets the merit of its eliminating dampness of regulating the flow of vital energy.Then mending with tonic, then rush down with cathartic, then rise with hydrargyrum oxydatum crudum, then falling with falling medicine." as with the bighead atractylodes rhizome with using; then having the effect of tonifying spleen and stomach; with ginseng, Radix Glycyrrhizae with the effect then having tonifying lung gas; logical fall the secret effect of large intestine gas with almond with then having, logical moisten the secret effect of large intestine blood with peach kernel with then having, with the tuber of pinellia with the effect then having eliminating dampness; with Poria cocos with the effect then having clearing damp; with dried orange peel with the effect then having sending down abnormally ascending preventing or arresting vomiting, warming cold phlegm with same the energy of rhizoma zingiberis, drink with the coptis is same treat gastrointestinal disease better efficacy with hot phlegm can be removed or directly take stomach and intestine.

The membrane of a chicken's gizzard returns spleen, stomach, small intestine, urinary bladder channel.Effect stomach strengthening and digestion promoting, arresting seminal emission, treating stranguria fossil.Cure mainly and do not disappear for dyspepsia, vomiting dysentery, infantile malnutrition, the enuresis, seminal emission, the puckery pain of urolithiasis, hypochondriac pain that courage is swollen.Compendium of Material Medica: the wine that disappears amasss, and takes with bean powder ball." the southern regions of the Yunnan Province book on Chinese herbal medicine ": wide middle invigorating the spleen, help digestion mill stomach.Control children's's breast food knot stagnant, the large muscle of tripe is blue or green, mass in the abdomen infantile malnutrition due to digestive disturbances or intestinalparasites.

Hawthorn stone fruit, caryoplasm is hard, and pulp is thin, and taste is micro-sour and astringent.Fruit is raw-eaten or make preserved fruit fruitcake, can be used as medicine after drying, Chinese distinctive medicine fruit dual-purpose seeds, there is the effects such as reducing blood lipid, blood pressure, cardiac stimulant, arrhythmia, also be simultaneously the good medicine of spleen benefiting and stimulating the appetite, relieving dyspepsia, phlegm reduction of blood circulation promoting, the disease such as, hernia, blood stasis full to chest diaphragm spleen, amenorrhoea has good curative effect.Flavone compound Vitexin in hawthorn is the medicine that a kind of antitumaous effect is stronger, and its extract all has certain effect to growth of cancer cells, propagation and infiltration metastasis in suppression body.

The pungent micro-hardship of rhizoma cyperi is sweet, and flat function cures mainly: regulate the flow of vital energy Xie Yu, menstruction regulating and pain relieving.For stagnation of QI due to depression of the liver, chest, the side of body, abdominal distention, indigestion, irregular menstruation, through closing dysmenorrhoea, cold hernia stomachache, swollen breasts." detailed outline " carries it: time loose, gas is trembled with fear epidemic disease, and profit three is burnt, Xie Liuyu, and the diet that disappears gathers, and phlegm and retained fluid ruffian is full, and instep swells, abdominal distension, beriberi, only trusted subordinate, limbs, head, order, tooth, all pains of ear, ulcer sores, spits blood, lower blood, hematuria, under married woman's uterine bleeding band, the moon wait uncomfortable, before tire postpartum all kinds of diseases and ailments.

Purple perilla gas delicate fragrance, taste is micro-pungent.Perilla leaf can fall apart exterior cold, and sweating power is comparatively strong, for chill table disease, seeing aversion to cold, heating, the disease such as lossless, often joining ginger with using; Having the stagnation of the circulation of vital energy concurrently as shown disease, having to be equal to rhizoma cyperi, dried orange peel and using.The wide middle perilla leaf of promoting the circulation of qi is used for the taste stagnation of the circulation of vital energy, uncomfortable in chest, evil of vomitting.Purple perilla at Chinese conventional Chinese medicine, and Japanese be used for cooking, be especially absolutely necessary when eating raw fish accompaniment, in Chinese minority area also useful it do vegetables or enter tea.Perilla leaf is also Su Ye, having function that is loose cold, relieving QI stagnancy in the stomach of inducing sweat, curing mainly anemofrigid cold, cough, fullness and oppression of chest and abdomen, the diseases such as n and V.Seed also claims perillaseed, has the function of antitussive and antiasthmatic, society's phlegm.The retortable perilla herb oil of purple perilla herb, the oil that seed goes out also claims perilla oil, and long-term edible perilla oil has obvious curative effects to treatment coronary heart disease and high fat of blood.

Bighead atractylodes rhizome bitter, sweet, temperature.Return spleen, stomach warp.Cure mainly strengthening the spleen and replenishing qi, eliminating dampness Li Shui, hidroschesis, antiabortive.Few for insufficiency of the spleen food, abdominal distension is had loose bowels, and phlegm and retained fluid is dizzy throbs with fear, oedema, spontaneous perspiration, fetal irritability.The bighead atractylodes rhizome has CDCC to oncocyte, can reduce the rate of increase of oncocyte, lowers the aggressive of tumor tissue, improves the ability of the antitumor reaction of body.Baizhu volatile oil has inhibitory action to mouse EC, lymphosarcoma ascitic type, the cancer of the esophagus (Eca109), sarcoma 180 etc.Atractylodes lactone B lumbar injection is to the murine sarcoma people.Also remarkable inhibitory action is had." property of medicine opinion " carries it: monarch, taste is sweet, pungent, nontoxic.Energy main large wandering arthritis, for many years diarrhea due to disorder of qi, trusted subordinate's distending pain, the broken place food that disappears, appetizing, removes sputum, except fever and chills, lets out under stopping.Interarea light is pleased, and preserves youthful looks, de-black.Swelling of harnessing the river is full, tells to vomit inverse, and crymodynia in abdomen, vomits and diarrhoea incessantly, and the cold dysentery of stomach Qi deficiency.

Radish seed, Chinese medicine name.For the dry mature seed of crucifer radish RaphanussativusL..Pungent, sweet, flat.Return lung, spleen, stomach warp.Effect helps digestion de-swelling, lowering the adverse-rising QI to resolve phlegm.Cure mainly for retention of food and drink, abdominal distention, constipation, stagnate and rush down dysentery, phlegm heap soil or fertilizer over and around the roots is breathed with cough." detailed outline ": the merit of radish seed, is longer than sharp gas.Raw to rise, ripely to fall, liter then tells wind phlegm, dispersing wind and cold, a sore rash; Fall and then determine asthma due to excessive phlegm cough, heavy after adjusting diarrhea, only, pain, is all the effect of sharp gas.

Bitter buckwheat is rich in bioflavonoid, linoleic acid, chromium element.Bitter buckwheat flavone not only can effectively promoting blood circulation and removing blood stasis, embolism resistance, reducing blood lipid, hypotensive, reduce cholesterol, reduce blood sugar, the composition of blood is purified, but also the fragility of microcirculation, reduction capillary can be improved, reduce its permeability, impaired vascular wall can be repaired.Bitter buckwheat is called " three fall pellet " by modern.

Purslane herb hyoscine, has clearing heat and promoting diuresis, removing toxicity for detumescence, anti-inflammatory, quenches the thirst, diuresis; Seed improving eyesight.Modern study, purslane is also containing abundant SL3 aliphatic acid and vitamin A sample material: SL3 aliphatic acid forms cell membrane, especially brain cell membrane and the necessary material of eye cell membrane; Vitamin A sample substance maintains epithelial tissue as skin, cornea and conjunctival normal function, participates in the synthesis of visual purple, strengthens retinal photoreceptor performance, also participates in many oxidizing process in body.In addition, purslane also can make veterinary drug and agricultural chemicals; Young stem and leaf can do vegetables etc.Purslane acid is cold, enters the heart channel of Hang-Shaoyin and walks blood system, function cooling blood and hemostasis, and carbuncle is treated in removing toxic substances; Enter large intestine again kind refrigerant blood control dysentery.By bloody flux, sore are commonly used.Purslane has effect of removing toxic substances, anti-inflammatory, diuresis, detumescence.Certain auxiliary therapeutic action is had to diabetes.Purslane contains 2.3 grams, protein, 0.5 gram, fat, 3 grams, carbohydrate, calcium 85 milligrams, 56 milligrams, phosphorus, iron 1.5 milligrams and potassium, manganese, copper, magnesium, zinc etc. in every 100 grams of cauline leafs.Also containing carrotene 2.23 milligrams, Catergen 3 milligrams, vitaminB10 .03 milligram, vitamin B2 0.11 milligram, 0.7 milligram, nicotinic acid, citric acid and several amino acids.Purslane is edible with young stem and leaf.Also shine after can completing and make dry vegetalbe.Purslane complete stool be used as medicine there is removing toxic substances, that inhibiting bacteria and diminishing inflammation, diuresis stop dysentery, ease constipation disappears is stagnant, debug, the drug effect such as improving eyesight and suppression uterine hemorrhage; External application can control the disease such as erysipelas, venomous snake bite.

Fructus Corni, cure mainly perverse trend fever and chills under the heart, Wen Zhong, by cold temperature numbness, goes three worms, for a long time clothes made light of one's life by commiting suicide reinforcing yin essence benefit essence, five viscera settling, logical nine orifices, stop the merit of dribbling urination; Take improving eyesight, brute force for a long time all the year round.Fructus Corni, have another name called cornus officinalis sieb et zucc, medicine jujube, real jujube, fructus corni, meat jujube etc., for China commonly uses rare traditional Chinese medicine, applicating history is long.It is gentle with its benefit power, establishing-Yang and do not help fire, enriching yin and oiliness diaphragm, convergence and do not stay evil wait special efficacy like by successive dynasties medical science use.Zhang Zhongjing is that monarch has formulated " chinkuei shin chewan pills " with Fructus Corni.According to chemical analysis, Fructus Corni contains the active ingredients such as the stronger cornin of physiologically active, tartaric acid, gallic acid, malic acid, resin, tannin and multivitamin, having and strengthen immunity, anti-inflammatory, the pharmacological action such as antibacterial, is the medicine simply commonly used in tcm clinical practice.

Heart of a lotus seed benevolence is conventional Chinese medicine. be again the food generally, often eaten, property slightly sweet flavor is slightly cold, and has inducing diuresis for removing edema, invigorating the spleen is dried, relaxing muscles and tendons removes the effect such as numbness, clearing away heat and eliminating pus, is conventional damp-clearing drug.Heart of a lotus seed benevolence is again a kind of beauty food, and normal food can keep human body skin gloss fine and smooth, eliminates acne, spot sparrow, senile plaque expelling, cyasma, butterfly macules, to furfur, acne, chap, pachylosis etc. has good efficacy.The kind Renhe root of the seed of Job's tears can be used as medicine again and cure the disease.Li Shizhen (1518-1593 A.D.) is recorded in Compendium of Material Medica: seed of Job's tears energy, and " invigorating spleen and reinforcing stomach, tonifying lung heat-clearing, removes wind prevailing over dampness.To cook a meal food, control cold air.Decoct drink, diuresis heat is drenched." in recent years, a large amount of scientific researches and clinical practice prove, the seed of Job's tears or a kind of cancer therapy drug, and Preliminary Identification, it can reach more than 35% to the inhibiting rate of cancer.

Flower of hyacinth dolichos Latin plant animal mineral name: DolichoslablabL. returns through spleen; Stomach; Large intestine channel.Medicinal material Ji Yuan: be the flower of legume French beans.Nature and flavor: flat; Sweet light; Nontoxic.Gui Jing: spleen; Stomach; Large intestine channel function cures mainly: expelling summer-heat and damp, and middle invigorating the spleen.The main summer hinders summer-heat and damp, heating, have loose bowels, dysentery, leukorrhea with reddish discharge, fall injure swollen.Flower of hyacinth dolichos contains former anthocyanin (proanthocyanidins), flavonoids (flavonoids), anthocyanidin (anthocyanidins), coumarin (conmarins)." book on Chinese herbal medicine is just read ": flower of hyacinth dolichos red person enter blood system and declare the stasis of blood, white person enters gas and divides and promoting the circulation of qi, and all flowers are all loose, therefore can fall apart evil by heat clearly, lets out the cards such as dysentery also to control Xia Yue

Specific embodiment 1:

First prepared by rhubarb, stir-fry, add alcohol extract, as component 1.

Then by bitter for all the other raw materials buckwheat, the dried rhizome of rehmannia, plantain seed, hawthorn, purslane, lotus leaf, heart of a lotus seed benevolence, gynostemma pentaphylla, Fructus Corni, cape jasmine, rhizoma cyperi, radish seed, dried orange peel, the dried immature fruit of citron orange, the bighead atractylodes rhizome, purple perilla, the membrane of a chicken's gizzard, flower of hyacinth dolichos, with alcohol extract, as component 2.

Again by 2 kinds of component mixing concentration extraction; Bottle after sterilizing, make oral liquid.

Specific embodiment 2:

Rheum officinale is excavated before autumn Mo, the cauline leaf withered or secondary spring germinateed, and removing radicula, scrapes off crust, valve cutting or section, rope wears bunchiness drying or convection drying, about 4500g, soaked 1-2 hour in ethanol, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extract, 100-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate reduced pressure concentration relative density is 80 DEG C 1.06 medicinal extract, heating be concentrated into paste, stand for standby use, becomes component 1.

By bitter for surplus stock buckwheat 1200g, dried rhizome of rehmannia 1300g, plantain seed 1200g, hawthorn 1300g, purslane 1200g, lotus leaf 1200g, heart of a lotus seed benevolence 1300g, gynostemma pentaphylla 1200g, Fructus Corni 1200g, cape jasmine 1300g, rhizoma cyperi 1200g, radish seed 1300g, dried orange peel 1200g, dried immature fruit of citron orange 1300g, bighead atractylodes rhizome 1200g, purple perilla 1200g, the membrane of a chicken's gizzard 1200g, flower of hyacinth dolichos 1200g, put into 10 times amount ethanol, soak 1-2 hour, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extract, 100-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate reduced pressure concentration relative density is 80 DEG C 1.15 filtrate, as component 2, by the mixing of two kinds of components, insert in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C, relative density is the concentrate of 1.25, sets to 0 ~ 5 DEG C of deepfreezes 24 hours, refrigeration liquid is added the filter aid diatomite of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 0.1g crude drug amount, after adding dextrin mediation, ultraviolet sterilization is bottled.

Specific embodiment 3

Excavate before autumn Mo, the cauline leaf withered or secondary spring germinateed, removing radicula, scrape off crust, valve cutting or section, rope wears bunchiness drying or convection drying, get the rhubarb be cut into small pieces, mix thoroughly with yellow rice wine, put in food steamer and steam, or put sealing in tank, sit in kettle, Steam by water bath is saturating, taking-up is dried, 2 ~ 3 persons are repeatedly steamed by upper method, after drying and ripening rheum officinale 5000g, steeped in 10 times amount ethanol, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extract, 100-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate reduced pressure concentration relative density is 80 DEG C 1.06 medicinal extract, heating is concentrated into paste, stand for standby use, become component 1.

By bitter for all the other raw materials buckwheat 1300g, dried rhizome of rehmannia 1300g, plantain seed 1500g, hawthorn 1300g, purslane 1200g, lotus leaf 1200g, heart of a lotus seed benevolence 1300g, gynostemma pentaphylla 1200g, Fructus Corni 1200g, cape jasmine 1300g, rhizoma cyperi 1200g, radish seed 1300g, dried orange peel 1300g, dried immature fruit of citron orange 1300g, bighead atractylodes rhizome 1500g, purple perilla 1300g, the membrane of a chicken's gizzard 1200g, flower of hyacinth dolichos 1500g, put boiling secondary in multi-function extractor by soaked raw material; Add up the water of medicinal material 10 times amount for the first time, decoct 1.5 ~ 2 hours, get decocting liquid, filter; Second time adds up the water of medicinal material 7 times amount, decocts 1 ~ 1.2 hour, gets twice decocting liquid mixing, filters; As component 2.By the mixing of two kinds of components, insert in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C, relative density is the concentrate of 1.25, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Refrigeration liquid is added the filter aid diatomite of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 0.1g crude drug amount; After adding dextrin mediation, ultraviolet sterilization is bottled.

Specific embodiment 4:

Excavate before autumn Mo, the cauline leaf withered or secondary spring germinateed, removing radicula, scrape off crust, valve cutting or section, rope wears bunchiness drying or convection drying, get the rhubarb be cut into small pieces, mix thoroughly with yellow rice wine, put in food steamer and steam, or put sealing in tank, sit in kettle, Steam by water bath is saturating, taking-up is dried, 2 ~ 3 persons are repeatedly steamed by upper method, after drying and ripening rheum officinale 4500g, then dried prepared RADIX ET RHIZOMA RHEI sheet is added water, then extractor heating extraction 2 times is put into, each 1-2 hour, remove supernatant, merge extract, 100-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate reduced pressure concentration relative density is 80 DEG C 1.06 medicinal extract, as component 1, by all the other raw materials described by bitter buckwheat 1200g, dried rhizome of rehmannia 1300g, plantain seed 1200g, hawthorn 1300g, purslane 1200g, lotus leaf 1200g, heart of a lotus seed benevolence 1100g, gynostemma pentaphylla 1100g, Fructus Corni 1200g, cape jasmine 1100g, rhizoma cyperi 1200g, radish seed 1300g, dried orange peel 1200g, dried immature fruit of citron orange 1300g, bighead atractylodes rhizome 1200g, purple perilla 1100g, the membrane of a chicken's gizzard 1200g, flower of hyacinth dolichos 1200g, put into 5-10 times of water gaging, soak 1-2 hour, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extract, 100-120 order filters, No. 2 extracts are merged and leaves standstill, decompression recycling ethanol, and to be concentrated into liquor strength be 0.6g crude drug/mL, after suction filtration, when the relative density of filtrate is about 20 DEG C 1.08, be decompressed to 0.03-0.08MPa, temperature remains on 60-80 DEG C, and being concentrated into relative density is 1.20, and the medicinal extract of temperature to 60 DEG C-70 DEG C, as component 2.The mixing of component 1 component 2 inserted in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C, relative density is the concentrate of 1.05, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Refrigeration liquid is added the filter aid diatomite of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 0.1g crude drug amount; Paste after concentrated adds propolis and is in harmonious proportion, and bottles after ultraviolet ray sterilization bactericidal.。

Pharmacological toxicity is tested

Experimental example 1: acute toxicity test of the present invention

One, test material: animal: Kunming mouse, body weight 18-25g, male and female half and half, Shandong University's biology laboratory breeding.Medicine: the present invention's (all raw material mixing decoction 2 times merges and filters, taking liquid) is containing 0.0365mg/ml.

Two, method:

1, LD50 calculates: adopt improvement karber's method, mouse is divided into 5 groups at random, often organize 10, male and female half and half, dissolve adding distil water of the present invention, are made into Cmax, by the administration of mouse maximum permission capacity, institute is followed successively by 18,14.4 to dosage by crude drug amount, 11.5,9.2,7.4 (g.kg-1), in animal fasting (can't help water) after 18 hours, administration at twice in one day (interval half an hour), each 0.5ml, observes animal dead situation.

2, maximum tolerated dose measures (MTD value): get mouse 20, each 10 of male and female.Adding distil water of the present invention is dissolved, is made into maximum concentration, by the maximal tolerance dose of animal, feed device and can twitch to inject to fill with and be as the criterion.In animal fasting (can't help water) after 18 hours, administration at twice in one day (interval half an hour), each 0.5ml (every ml containing crude drug 0.36g), total dose is 18g crude drug/kg.d, 300 times of quite clinical adult 50Kg body weight consumption.Continuous Observation 7 days after administration.

Three, result of the test:

In LD50 calculates when giving mouse with maximum acceptable concentration and maximum permission capacity (18g/Kg.d), have no dead mouse, namely LD50 is not measured, ask maximum tolerated dose only, in 7 day observation period, its appetite of animal, activity, hair color, the state of mind etc. are all normal, grow normal, there are no death.Namely select the 300 times of doses being equivalent to clinical dosage, and have no adverse reaction, show that acute toxicity is minimum, MTD > 18g/Kg.d.

Experimental example 2: the result of the test of acute toxicity and long term toxicity

Acute toxicity test: give the present invention by the disposable gavage of small white mouse, maximum concentration 35%, maximum gavage capacity 0.4ml/10g, dosage 14g/kg (every g medicinal powder is equivalent to 10g crude drug), Continuous Observation 7 days, do not find any toxic reaction, because concentration and dosage cannot increase, therefore fail to measure the LD50 of this medicine.Maximum tolerance determination: with maximum concentration, maximum gavage capacity, mice lavage administration 3 times, 5 hours, interval, then Continuous Observation 7 days, none example is dead.Medicinal powder dosage is > 42g/kg. day (every g medicinal powder is equivalent to 10g crude drug), calculates 420 times of the clinical consumption per day that is equivalent to be grown up by kg body weight.

Long term toxicity test: whether produce toxic reaction for observing long-term prescription, give rat the present invention respectively and raise clothes, by adult 70 times of clinical consumption per day and 35 times (i.e. 7g/kg/ day and 3.5g/kg/ day), give continuously and feed 8 weeks, have no the behavior of rat, feed, body weight appearance extremely, with control group ratio, routine blood test, hepatic and renal function, the change all without exception of various important organ, within the scope of institute's dosage, do not find any toxicity of the present invention.Confirmed by the acute and chronic toxicity test of animal, safe range of the present invention is comparatively large, is a kind of safe and reliable defaecation product.

Pharmacological experiment:

1 materials and methods

1.1 materials and instrument

Experimental rat feeds high lipid food standard formula full price mouse feed 60%, lard 12%, sucrose 5%, milk powder 5%, peanut 5%, egg 10%, sesame oil 1%, salt 2% used, is processed by Animal Science Co., Ltd of University Of Qingdao; Other agents useful for same are that commercially available analysis is pure; The firelight or sunlight biological Co., Ltd of T-CHOL detection kit, triglycerides detection kit and HDL detection kit wound; The male SD rat 100 of firm ablactation is only provided by University Of Qingdao's Experimental Animal Center, raises in this school SPF level animal experimental center that [temperature (24 ± 2) DEG C, relative humidity is 50%.Satrorius company of BP211D type electronic analytical balance Germany; 202 type Constant Temp. Oven Shanghai Suo Pu Instrument Ltd.; Sigma company of 1-15PK small desk refrigerated centrifuge Germany; TU-1800S ultraviolet-uisible spectrophotometer Beijing Puxi General Instrument Co., Ltd; PUZS-300 full automatic biochemical apparatus Nanjing Pu Lang medical equipment Co., Ltd; Stainless steel rat metabolism cage Beijing good Asource industry Science and Technology Ltd.; SOX406 Milko-Tester Jinan Hanon Instruments Ltd..

1.2 tea of the present invention feed the impact of rat body weight increase to high fat

1.2.1 animal used as test and the grouping growth male Wistar rat of 3 months, body weight (210 ± 15) g, sum 50, thered is provided by University Of Qingdao's Experimental Animal Center, raise in this school SPF level animal experimental center (temperature (24 ± 2) DEG C, relative humidity is 50%).Be divided into 5 groups at random by body weight, often organize 10.Animal grouping is as follows with administrations:

Blank group (Blank): gavage etc. hold physiological saline, continuous 9 weeks; Radix Et Rhizoma Rhei extract group (A): 400mg/kg/d, continuous gavage 9 weeks; All the other raw material extract group (B): 400mg/kg/d, continuous gavage 9 weeks; Low dose group of the present invention (C): 400mg/kg/d, continuous gavage 9 weeks; High dose group of the present invention (D): 800mg/kg/d, continuous gavage 9 weeks.

1.2.2 the original body mass of observation index and detection method precise rat, is distributed into cage, 1, every cage, ensures the abundant supply of water and food, measures weekly the intake of food and water, measure increased weight weekly simultaneously.1st week and the 9th week timing eye socket get blood 0.5mL, and immediately in 2500r/min refrigerated centrifuge 2min, automatic clinical chemistry analyzer detects total sterol, high-density protein and content of triglyceride in serum.

The impact that 1.3 the present invention lose weight on obese rat

1.3.1 Diet-induced obesity rat molding method 10 is standard full price mouse forage feed, feeds for 90 with high lipid food.Feed after 3 months, exceed chow diet with body weight and feed 20% of rat body weight mean value for obesity standard, modeling success 49, success rate is 54.4%.

1.3.2 grouping and the successful obese rat of processing method modeling change to the nursing of standard complete feed subsequently, are divided into 5 groups at random by body weight, often organize 9.Blank group (Blank): model comparison rat, gavage equal solvent physiological saline, continuous 4 weeks; Radix Et Rhizoma Rhei extract group (A): 400mg/kg/d, gavage treatment 4 weeks; All the other raw material group extract group (B): 400mg/kg/d, gavage treatment 4 weeks; Low dose group of the present invention (C): 400mg/kg/d, gavage treatment 4 weeks; High dose group of the present invention (D): 800mg/kg/d, gavage treatment 4 weeks.

1.3.3 observation index and detection method weigh body weight before and after treatment with electronic scale, and calculate body weight decrement before and after administration, before accounting for administration using body weight decrement, the percentage of body weight is as weight-loss ratio.Experiment terminates the previous day, gets blood 2mL to rat eye socket, and immediately in 2500r/min refrigerated centrifuge 2min, automatic clinical chemistry analyzer detects total sterol, high density lipoprotein level bletilla content of triglyceride in serum.Experiment terminates rear executions rat, to get under omoplate fatty (brown fat) after item and weighs; Get all Abdominal Wall Fats of kidney and epididymal adipose tissues (white adipose), represent visceral fat mass with both sums; Calculate fat-body anharmonic ratio after interior fat weight ratio and item simultaneously.

1.4 data statistic analysis

Data statistic analysis is carried out with SPSS100 software.

2 results and analysis

2.1 the present invention feed the fat-reducing effect to obese rat

In whole experimentation, each test group of animals is without obviously taking bad reaction, and specific experiment result is as shown in table 1.

After modeling success, the body weight average of obese rat is more than 630g, give active material gavage after 4 weeks, tartary buckwheat extract group, the body weight of high dose group obese rat of the present invention comparatively control group has conspicuousness to alleviate (p < 0.05), all the other raw extract groups also have certain phenomenon that loses weight, but compare with blank group not obvious (p > 0.05), effect of the present invention is better than independent Chinese rhubarb extract and other raw extracts (p < 0.05), and present certain dose-effect relationship, high dose better effects if.

The relevant body weight parameters (n=9, X ± SD) of tested obese rat respectively organized by table 1

Note: represent there was no significant difference (p > 0.05) with column data acceptance of the bid note same letter; Difference then has significant difference (p < 0.05); Table 2-table 3 is same.

As shown in Table 2, compare with blank group, alone bitter buckwheat and other raw materials can reduce visceral adipose and the internal organ fat body ratio (p < 0.05) of obese rat, the present invention has the effect (p < 0.05) obviously reducing obese rat interior fat equally, its effect is even better than rheum officinale group or other raw extract groups, high dose more remarkable effect of the present invention, so that the effect (p < 0.05) of fat body ratio after fat and item after also showing the item significantly reducing obese rat.

The different fat sites content (n=9, X ± SD) of tested obese rat respectively organized by table 2

Table 3 result shows, give each experimental group material and all obviously can reduce obese rat serum cholesterol, triglycerides (with blank group ratio, p < 0.05), and the effect of high and low dose of the present invention compares with other groups and has obvious difference (p < 0.05), illustrate that high and low dose effect of the present invention is better than bitter buckwheat group or other raw extract groups (p < 0.05).

The lipids contents (n=9, X ± SD) of tested obese rat respectively organized on the 4th week by table 3

Experimental result shows, the present invention all has obvious reducing effect to Mouse Weight, fat and serum triglyceride, and can improve microcirculation, and reducing weight and blood fat effect has been described.

3 brief summaries

Rheum officinale has significant hypotensive effect.In acute experiment, rheum officinale preserved material and remove alcohol rheum officinale ingredients intravenous administration, can make animal used as test rabbits blood pressure obviously reduce.Rhubarb preparation intravenous administration, can make the blood pressure of anesthetized dog reduce, and cardiac myocytes oxygen demand increases, and improves myocardium coefficient of oxygen utilization.Rheum officinale preserved material, ingredients all have the effect reduced blood pressure.

Rheum officinale is by osmotic effect, interstitial fluid body is impelled to reach dilute blood effect to Ink vessel transfusing transfer, increase blood to hold, reduce biologically active pdgf, hematocrit is made to turn round CT) decline, hypercoagulative state is improved, makes hyperosmosis recover normal, improve plasmin activity, promote that occluding vascular leads to again.

Rheum officinale has inhibitory action to VSMC, the strongest with aloe-emodin effect, aloe-emodin can Inhibit proliferaton, prevent vascellum endometrial hyperplasia pathology and vascular wall thickening coarse, thus the vascular wall produced after can alleviating arterial injury is narrow, the expansible blood vessel of rheum officinale, reduce vascular resistence, increase CBF, blocks cellular Ca2+ influx, improve the utilization rate of cardiac muscle to oxygen, reduce lipid peroxidation and myocardial damage, prevent thrombosis, improve body circulatory function, cardiovascular and cerebrovascular diseases add with rheum officinale, to treatment hypertension, coronary heart disease and atherosclerosis development have obvious curative effects, especially more obvious with angiotensin converting enzyme inhibitor coupling effect.

Rheum officinale can make the mice serum of hyperlipidemia of yolk and high lipid food induction and hepatic cholesterol, TG and lipid peroxide obviously reduce, and its active ingredient may be that green onion is waken up class, catechin and polysaccharide.Rhubarb concoction without impact on normal rabbit serum cholesterol, but raises then have obvious inhibitory action to because taking serum cholesterol that cholesterol causes, and serum cholesterol and total phospholipids ratio obviously decline.

Modern basic medical research confirms, in body, the surplus of oxygen radical is the cause of various diseases, and rheum officinale be a class effect very strong free radical scavenger and lipid peroxidation enzyme inhibitor, there is wide spectrum scavenging action to multiple free radical.Experiment is had to show, archen, Rhein, aloe-emodin react to rat cerebral even slurry lipid peroxidation or Maillard the extremely weak chemiluminescence caused all cancellation effect, there is linear relationship in the inhibiting rate of this action intensity and MDA, wherein archen is to FeSO; The rejection ability of the rat heart mitochondrial lipid peroxidation caused is better than VE, and therefore Active Constituents in Rhubarb probably has inhibitory action to the tight of mitochondrial membrane lipid peroxylradicals.

Claims

1. the rheum officinale oral liquid of a Weight-reducing and lipid-lowering, it is characterized in that, the rheum officinale oral liquid of described Weight-reducing and lipid-lowering comprises the bulk drug of following weight portion: rheum officinale 10 ~ 50 parts, bitter buckwheat 10 ~ 20 parts, 10 ~ 20 parts, the dried rhizome of rehmannia, plantain seed 10 ~ 20 parts, hawthorn 10 ~ 20 parts, purslane 10 ~ 20 parts, 10 ~ 20 parts, lotus leaf, heart of a lotus seed benevolence 10 ~ 20 parts, gynostemma pentaphylla 10 ~ 20 parts, Fructus Corni 10 ~ 20 parts, cape jasmine 10 ~ 20 parts, rhizoma cyperi 10 ~ 20 parts, radish seed 10 ~ 20 parts, dried orange peel 10 ~ 20 parts, the dried immature fruit of citron orange 10 ~ 20 parts, the bighead atractylodes rhizome 10 ~ 20 parts, purple perilla 10 ~ 20 parts, the membrane of a chicken's gizzard 10 ~ 20 parts, flower of hyacinth dolichos 10 ~ 20 parts.

2. the rheum officinale oral liquid of Weight-reducing and lipid-lowering according to claim 1, it is characterized in that, in the rheum officinale oral liquid of described Weight-reducing and lipid-lowering, the parts by weight of various raw material are: rheum officinale 10 ~ 30 parts, bitter buckwheat 10 ~ 15 parts, 10 ~ 15 parts, the dried rhizome of rehmannia, plantain seed 10 ~ 15 parts, hawthorn 10 ~ 15 parts, purslane 10 ~ 15 parts, 10 ~ 15 parts, lotus leaf, heart of a lotus seed benevolence 10 ~ 15 parts, gynostemma pentaphylla 10 ~ 15 parts, Fructus Corni 10 ~ 15 parts, cape jasmine 10 ~ 20 parts, rhizoma cyperi 10 ~ 20 parts, radish seed 10 ~ 20 parts, dried orange peel 10 ~ 20 parts, the dried immature fruit of citron orange 10 ~ 20 parts, the bighead atractylodes rhizome 10 ~ 20 parts, purple perilla 10 ~ 20 parts, the membrane of a chicken's gizzard 10 ~ 20 parts, flower of hyacinth dolichos 10 ~ 20 parts.

3. the rheum officinale oral liquid of Weight-reducing and lipid-lowering according to claim 1, it is characterized in that, the parts by weight that described rheum officinale leads to various raw material in the just oral liquid of losing weight are: rheum officinale 10 ~ 40 parts, bitter buckwheat 10 ~ 20 parts, 10 ~ 20 parts, the dried rhizome of rehmannia, plantain seed 10 ~ 20 parts, hawthorn 10 ~ 20 parts, purslane 10 ~ 20 parts, 10 ~ 20 parts, lotus leaf, heart of a lotus seed benevolence 10 ~ 20 parts, gynostemma pentaphylla 10 ~ 20 parts, Fructus Corni 10 ~ 20 parts, cape jasmine 10 ~ 15 parts, rhizoma cyperi 10 ~ 15 parts, radish seed 10 ~ 15 parts, dried orange peel 10 ~ 15 parts, the dried immature fruit of citron orange 10 ~ 15 parts, the bighead atractylodes rhizome 10 ~ 15 parts, purple perilla 10 ~ 15 parts, the membrane of a chicken's gizzard 10 ~ 15 parts, flower of hyacinth dolichos 10 ~ 15 parts.

4. the preparation method of the rheum officinale oral liquid of Weight-reducing and lipid-lowering as described in any one of claims 1 to 3 item, it is characterized in that, the preparation process of the rheum officinale oral liquid of described Weight-reducing and lipid-lowering comprises following aspect:

A. the preparation of rheum officinale, adds alcohol extract, as component 1;

5. the preparation method of the rheum officinale oral liquid of Weight-reducing and lipid-lowering according to claim 4, it is characterized in that, in described step a, rheum officinale is excavated before autumn Mo, the cauline leaf withered or secondary spring germinateed, removing radicula, scrape off crust, valve cutting or section, rope wears bunchiness drying or convection drying, naturally dry after taking out, put into 10 times amount ethanol, soak 1-2 hour, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extract, 100-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate reduced pressure concentration relative density is 80 DEG C 1.05 filtrate, as component 1.

6. the preparation method of the rheum officinale oral liquid of Weight-reducing and lipid-lowering according to claim 4, is characterized in that, in described step b, all the other bulk drugs are put into the 10 times amount ethanol accounting for its quality, soak 1-2 hour, start to heat extraction 2 times, each 1-2 hour, remove supernatant, merge extract, filter with 100-120 order, then be the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, ultrafiltrate reduced pressure concentration is relative density when being 80 DEG C 1.05 filtrate, as component 2.

7. the preparation method of the rheum officinale oral liquid of Weight-reducing and lipid-lowering according to claim 4, is characterized in that, in described step c, after above-mentioned two kinds of components mixing, insert in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C, relative density is the concentrate of 1.25, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Refrigeration liquid is added the filter aid diatomite of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 0.1g crude drug amount, then adds dextrin, bottle after ultraviolet sterilization.

8. the preparation method of the rheum officinale oral liquid of Weight-reducing and lipid-lowering as described in any one of claims 1 to 3 item, it is characterized in that, the preparation process of the rheum officinale oral liquid of described Weight-reducing and lipid-lowering can also comprise the following steps:

9. the preparation method of the rheum officinale oral liquid of Weight-reducing and lipid-lowering according to claim 8, it is characterized in that, in described step a, excavate before autumn Mo, the cauline leaf withered or secondary spring germinateed, removing radicula, scrape off crust, valve cutting or section, rope wears bunchiness drying or convection drying, get the rhubarb be cut into small pieces, mix thoroughly with yellow rice wine, put in food steamer and steam, or put sealing in tank, sit in kettle, Steam by water bath is saturating, taking-up is dried, 2 ~ 3 persons are repeatedly steamed by upper method, drying and ripening rheum officinale, then dried prepared RADIX ET RHIZOMA RHEI sheet is added water, then extractor heating extraction 2 times is put into, each 1-2 hour, remove supernatant, merge extract, 100-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate reduced pressure concentration relative density is 80 DEG C 1.06 medicinal extract, as component 1, in described step b, the rheum officinale dregs of extraction are put into together with all the other raw materials described and accounts for its quality 5-10 times water gaging, soak 1-2 hour, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extract, 100-120 order filters, No. 2 extracts are merged and leaves standstill, reducing pressure and being concentrated into liquor strength is 0.6g crude drug/mL, after suction filtration, when the relative density of filtrate is about 20 DEG C 1.08, be decompressed to 0.03-0.08MPa, temperature remains on 60-80 DEG C, and being concentrated into relative density is 1.20, and the medicinal extract of temperature to 60 DEG C-70 DEG C, as component 2.

10. the preparation method of the rheum officinale oral liquid of Weight-reducing and lipid-lowering according to claim 8, it is characterized in that, in described step c, reduced pressure concentration tank is put into after component 1 being mixed with component 2, decompression recycling ethanol, being concentrated into liquor strength is 0.1g crude drug/mL, when suction filtration to the relative density of filtrate is 20 DEG C 1.06; Above-mentioned filtrate, after the large pore resin absorption column absorption that volume is 10L, with deionized water or the distilled water wash-out of 10 times of resin column volumes, then uses 95% ethanol elution of 5 times of resin column volumes, collect ethanol eluate, remove solvent, then be in harmonious proportion honey, bottle after ultraviolet ray sterilization bactericidal.