CN104206594A

CN104206594A - Herba Taxilli health-care tea capable of lowering blood pressure and blood lipid and preparation method thereof

Info

Publication number: CN104206594A
Application number: CN201410425408.3A
Authority: CN
Inventors: 不公告发明人
Original assignee: Qingdao Hengbo Instrument Co Ltd
Current assignee: Qingdao Hengbo Instrument Co Ltd
Priority date: 2014-08-27
Filing date: 2014-08-27
Publication date: 2014-12-17

Abstract

The invention provides a Herba Taxilli health-care tea capable of lowering blood pressure and blood lipid. The Herba Taxilli health-care tea comprises the following raw materials in parts by weight: Herba Taxilli 10-50, Uncaria tomentosa 10-20, Prunella vulgaris 10-20, white mulberry root-bark 10-20, Semen Cassiae 10-20, Wolfiporia extensa 10-20, Salvia miltiorrhiz 10-20, Rhizoma Chuanxiong 10-20, Astragalus mongholicus 10-20, Radix Polygonum Multiflorum Preparata 10-20, Curculigo orchioides 10-20, semen raphani 10-20, Glossy privet fruit 10-20, white paeony root 10-20, Japanese knotweed 10-20, and Flos Sophorae 10-20. The traditional Chinese medicine tea can completely solve the hypertension problem. Unlike western medicines which dilate blood vessels to temporarily lower the blood pressure and improve hypertension syndrome, the traditional Chinese medicine tea can reduce blood lipid, promote blood circulation, soften blood vessels, induce diuresis, expel toxin and reduce pressure and the tea is developed according to the root cause of hypertension and thus has very lasting effect of lowering blood pressure. Moreover, the tea can eliminate the uncomfortable symptoms such as dizziness, headache, nausea, inappetence and edema which are caused by hypertension syndrome and antihypertensive western medicines. The traditional Chinese medicine tea has features of lasting antihypertensive therapeutic effect, safety, reliability and innocuity and is worth promoting.

Description

Parasitic loranthus health protection tea of a kind of hypertension and hyperlipemia and preparation method thereof

Technical field

The present invention relates to the health products containing deriving from plant composition, particularly a kind of parasitic loranthus health protection tea and preparation method thereof of hypertension and hyperlipemia.

Background technology

Hypertension is the important risk factor causing heart disease, cerebrovascular disease, kidney trouble to occur and develop, and is the modal chronic disease of global human.China's prevalence of hypertension rate sustainable growth, the death that cardiovascular and cerebrovascular diseases cause has been positioned at first of the cause of death of China resident, becomes the major disease threatening China's residents ' health.The generation of cardiovascular and cerebrovascular diseases with develop over half relevant with hypertension, therefore effectively controlling hypertension is the key preventing cardiovascular and cerebrovascular diseases.In high blood pressure, more than 95% is essential hypertension, and the pathogenesis of essential hypertension is complicated, illustrates not yet completely so far.Think multifactor coefficient result at present, h and E factor is mainly through following approach regulation and control blood pressure: the retention of sodium salt kidney, inner skin cell function imbalance, stomodaeal nervous system, RAS (rennin-angiotensin system, RAS), insulin resistance etc.

The final purpose of Treatment of Hypertension reduces hyperpietic's heart, the incidence of cerebrovascular disease and the death rate.Treatment of Hypertension should establish controlling of blood pressure desired value.On the other hand, hypertension usually merges with the hazards of other hearts, cerebrovascular disease and exists, such as hypercholesterolemia, obesity, diabetes etc., collaboratively increases the weight of cardiovascular disease risk, and remedy measures should be comprehensive.1. behavior of making the life better loses weight.2. reduce sodium salt to take in.3. calcium and sylvite is supplemented.4. fat intake is reduced.5. motion is increased.6. give up smoking, limit and drink.

Day by day flourishing due to economy, the continuous lifting of modern's living standard, cause people too much have deep love for enjoy, do not notice that the life style of oneself, behavioural habits, diet are had a liking for, thus the disease caused.Society with fast rhythm lives, the operating pressure of keen competition, serious threat is caused to the physical and mental health of modern, add that long-term diet is unreasonable, that is: smart grain replaces coarse food grain completely, the agricultural chemicals remained in the absorption of a large amount of three height (high heat, high protein, higher fatty acid), more than three (anticorrisive agent is many, flavoring agent is many, hormone many) food and food, chemical fertilizer stockpiling in vivo, add air, pollution of waterhead and amount of exercise less than normal, obesity and hypertensive diabetes have just become the rich man's disease of city gang.

When the reason that diabetes cause blood fat to increase is due to diabetes patient's insufficient insulin, body lactonase activity lowers, and therefore easily blood fat increases.Diabetes itself also accompany fat, protein and water, dielectric disorder except carbohydrate metabolism disturbance simultaneously on the other hand.Often there is free fatty to mobilize out from fat depot, triglycerides and FFA concentrations in blood are increased.Diabetes B people takes food too much on the one hand again, and motion is few, and impel lipid synthesis in body to increase, this is also the reason causing blood fat to increase.And fat companion's high fat of blood person, because insulin receptor number reduces relatively, thus produce insulin resistance, easy induced Diabetic.Diabetes are a kind of syndrome due to insulin secretion, insulin action or both carbohydrate, protein and fat metabolic disturbances simultaneously caused by existing defects.Essential characteristic is that blood sugar increases, long-term damage is dysfunction and the exhaustion of various organ, comprise the vascular conditions of constantly progress, namely PVR, blind, ephrosis, renal failure, DPN companion foot ulcers, amputation and autonomic nervous function change, and also have the danger of ever-increasing cardiovascular, the cerebrovascular and peripheral angiopathy.

Parasitic loranthus bitter, sweet, property is put down.Return liver, kidney channel.Property get a breathing space and, can rise and can fall.1. filling liver kidney, strengthening the bones and muscles, wines used as antirheumatic.Lose for kidney deficiency and liver, the deficiency of blood that articular instability, the muscles and bones impotence of supporting are soft, soreness of waist and knee joint, as duhuo jisheng decoction.2. nourishing blood and preventing abortion.This product energy nourishing blood and preventing abortion gas, the solid feotus vitality of kidney tonifying, for deficiency of blood fetal irritability.These product are sweet flat, function tonifies the liver and kidney, strengthening the muscles and bones, taste sweet again can wines used as antirheumatic, treat numbness pain, by lumbago due to the kidney deficiency, fetal irritability and rheumatism with the passing of time body ressitance weakened while pathogenic factors prevailing commonly used.

Parasitic loranthus is the most suitable to arthralgia due to wind-dampness, kidney deficiency and liver, soreness of waist and knee joint, and the normal and compatibility such as levisticum, the root of bidentate achyranthes is applied., women through multi-band under kidney deficiency and liver, lumbocrural pain, muscles and bones unable person empty to old man's body also often apply with the compatibility such as cassia seed, teasel root.Suffer from a deficiency of the kidney for liver lose, blood, fetal irritability under threatened abortion caused by the debility of chong and ren channels, the compatibilities such as normal and teasel root, the seed of Chinese dodder, donkey-hide gelatin.In addition, these product have hypotensive effect again, are usually used in hypertension clinically in recent years.

Parasitic loranthus is rich in mistletoe stem, leaf is containing oleanolic acid (Oleano-lic), β-amyrin (β-Amyrin), meso inositol (Mesoi nositol), flavone compound, still isolate Lupeol (Lupeol), cupreol (β-Sitosterol) and glycosides displayed. parasitic loranthus stem and branch with leaf is containing Quercetin (Quercetin) and avacularin (Avicularin). and mistletoe contains oleanolic acid (oleanollcacid), β-amyrin (β-amyrin), mysoinositol (mesoinositol), lupeol (lupeol), myristic acid (myristicacid), mistletoe glucoside first, yellow mistletoe glucoside (flavoyadorinin) A, B, high yellow mistletoe glucoside (homoflavoyadorinin) B, viscumneoside (viscumneoside) I, II, homoeriodictyol (homoeriodictyol).In addition, still containing betulic acid (betulicacid), Daucosterol (daucosterol) etc.Parasitic loranthus, containing Flavonoid substances, is mainly avicularin (avicularin), i.e. Quercetin-3-arabinoside, Quercetin (quercetin) and quercitrin (quercitrin).These product, containing avicularin and avacularin (avicularin), are Quercetin-3-arabinoside, also containing Quercetin.

Pharmacological action

One diuresis

Fiber crops jealous woman dog, with avacularin and avicularin 0.5 mg/kg of intravenous injection, can cause diuresis, acts on more remarkable when increasing dosage.In chronic rat test, no matter oral or injection, namely 34 mgs/kg start there is significant diuresis.Though its action intensity is not as good as aminophylline, its toxicity is only 1/4 of aminophylline, therefore its treatment width is larger.

Two hypotensive effects

Though avacularin has hypotensive effect to anesthetized dog, continue very short, and easily produce tolerance rapidly.According to preliminary test, on the isolated guinea pig heart sample of normal beats and vibration, parasitic loranthus (electuary) all has the effect of diastole coronary vasodilator, and can resist pituitrin, is then first suppress to increase afterwards to myocardial contractive power.

Three antivirus actions

Parasitic loranthus decoction in vitro (monkey kidney adhesion tissue cultures) has significant inhibitory action to poliovirus and other enteroviruses, poliovirus and medicine directly contact in one hour, namely suppressed, may be direct deactivation.

" Bencao Jingshu ": parasitic loranthus, its bitter but sweet flavor, its gas is gentle, cold not hot, admittedly should be nontoxic.It cures mainly in detail, take out its elite for one, therefore function compares Sang Yousheng in mulberry.Pain in the back and children's carry on the back by force, all the time of blood deficiency, and carbuncle is swollen many due to ying-qi heat.Skin does not fill, due to the deficiency of blood.Tooth person, also, originator, also, beneficial blood then sends out China to She of blood to She of bone, and the sufficient then tooth of kidney qi is hard and an eyebrow is long.Blood contains then tire peace certainly.Woman's metrorrhagia and internal injury deficiency, all events of heat in the deficiency of blood.Postpartum She's disease, all by blood system, agalactia, also by the deficiency of blood.Metal-inflicted wound is then hindered entirely in blood.To come up all diseases, there's no one who doesn't or isn't know and have heat institute to send out by the deficiency of blood, this property of medicine can beneficial blood, thus also lead also.Hold concurrently and can wet by core, therefore also treat numbness." herbal classic is met former ": She's gas of parasitic mulberry and give birth to, property is specially dispeled the wind by wet, logical blood vessels of adjusting, therefore " herbal classic " is got and controlled married woman's pain in the back, and children's carries on the back and waits sick by force, and Xuemaitong is adjusted and skin eyebrow must be all shady by it, namely have carbuncle swollen, also must dissipate." book on Chinese herbal medicine is looked for the truth ": parasitic loranthus, number wants agent for kidney tonifying and enriching blood.Edge Shen controls bone, sends out blood main, bitter man's kidney, and it is strong that kidney must mend then muscles and bones, unlikely hemorrhoid repeatly and sour.Sweetly enrich blood, blood must be mended, send out fill with shady by it and not tangerine come off.Therefore all in and pain in the back, the sincere disease of muscles and bones, tire are fallen, outer and metal-inflicted wound, skin rheumatism, what one is not thought whereby and cures mainly." herbal classic ": main pain in the back, children's carries on the back by force, and carbuncle swells, antiabortive, fills skin, hard, tooth, long man.

Modern selects some health foods or functional food to be to improve the health.The function of health products mainly improves blood circulation of human body, enriching yin and nourishing kidney, to reach hypoglycemic step-down; Improve the effect of body immunity.The various health products sold on the market now, dragons and fishes jumbled together for medicine, and the amusement of great majority just false propaganda, what have does not only have health-care components, also causes the huge injury of the person.Chinese medicine odor is poor, and a lot of people is reluctant long-term taking; Even if take, be medicine three points of poison, allow during people's long-term taking and also produce resisting psychology.The hypotensive tea of Chinese medicine of the present invention solves hypertension problem from basic, is that temporary the reducing blood pressure of hemangiectasis improves symptom, the mechanism that the present invention is hypotensive: fat eliminating unlike Western medicine, promote blood circulation, softening blood vessel, diuresis, toxin expelling, decompression is that the basic reason produced from hypertension is started with, hypotensive very lasting, and, the dizziness that hypertension and hypotensive Western medicine bring can also be eliminated simultaneously, headache, feel sick, poor appetite, the malaise symptoms such as oedema.The hypotensive curative effect of Chinese medicine is lasting, and safety is reliably, nontoxic, is worth promoting.

Summary of the invention

Technical problem to be solved by this invention is, Western medicine is that temporary the reducing blood pressure of hemangiectasis improves symptom, the mechanism that the present invention is hypotensive: fat eliminating, promote blood circulation, softening blood vessel, diuresis, toxin expelling, decompression is that the basic reason produced from hypertension is started with, hypotensive very lasting, can also eliminate the dizziness that hypertension and hypotensive Western medicine bring, headache, feels sick simultaneously, poor appetite, the malaise symptoms such as oedema.The hypotensive curative effect of Chinese medicine is lasting, and safety is reliably, nontoxic, is worth promoting.Chinese medicine odor is poor, and a lot of people is reluctant long-term taking; Even if take, be medicine three points of poison, allow during people's long-term taking and also produce resisting psychology.Parasitic loranthus is sweet in flavor and cold in property, enters lung, liver, kidney channel.Property get a breathing space and, can rise and can fall.Can filling liver kidney, strengthening the bones and muscles, wines used as antirheumatic.These product have hypotensive effect again, are usually used in hypertension clinically in recent years.The micro-bitter glycol of the present invention; Add some promoting blood circulation and removing blood stasis, mouthfeel is light, does not destroy the Chinese medicine that parasitic loranthus taste is sweet, does not affect mouthfeel, makes people be easy to accept, can reach effect of hypertension and hyperlipemia preferably.

For solving above-mentioned technical barrier, the invention provides a kind of parasitic loranthus health protection tea of hypertension and hyperlipemia, described in it, parasitic loranthus health protection tea comprises the raw material of following parts by weight: parasitic loranthus 10 ~ 50 parts, yncaria stem with hooks 10 ~ 20 parts, selfheal 10 ~ 20 parts, the root bark of white mulberry 10 ~ 20 parts, cassia seed 10 ~ 20 parts, 10 ~ 20 parts, Poria cocos, the red sage root 10 ~ 20 parts, Ligusticum wallichii 10 ~ 20 parts, the Radix Astragali 10 ~ 20 parts, RADIX POLYGONI MULTIFLORI PREPARATA 10 ~ 20 parts, thizoma curculiginis 10 ~ 20 parts, radish 10 ~ 20 parts, the fruit of glossy privet 10 ~ 20 parts, the root of herbaceous peony 10 ~ 20 parts, giant knotweed 10 ~ 20 parts, 10 ~ 20 parts, sophora flower.

The parasitic loranthus health protection tea of described hypertension and hyperlipemia, in parasitic loranthus health protection tea described in it, the parts by weight of various raw material can be: parasitic loranthus 10 ~ 30 parts, yncaria stem with hooks 10 ~ 15 parts, selfheal 10 ~ 15 parts, the root bark of white mulberry 10 ~ 15 parts, cassia seed 10 ~ 15 parts, 10 ~ 15 parts, Poria cocos, the red sage root 10 ~ 15 parts, Ligusticum wallichii 10 ~ 15 parts, the Radix Astragali 10 ~ 15 parts, RADIX POLYGONI MULTIFLORI PREPARATA 10 ~ 20 parts, thizoma curculiginis 10 ~ 20 parts, radish 10 ~ 20 parts, the fruit of glossy privet 10 ~ 20 parts, the root of herbaceous peony 10 ~ 20 parts, giant knotweed 10 ~ 20 parts, 10 ~ 20 parts, sophora flower.

The parasitic loranthus health protection tea of described hypertension and hyperlipemia, in parasitic loranthus health protection tea described in it, the parts by weight of various raw material can also be: parasitic loranthus 10 ~ 40 parts, yncaria stem with hooks 10 ~ 20 parts, selfheal 10 ~ 20 parts, the root bark of white mulberry 10 ~ 20 parts, cassia seed 10 ~ 20 parts, 10 ~ 20 parts, Poria cocos, the red sage root 10 ~ 20 parts, Ligusticum wallichii 10 ~ 20 parts, the Radix Astragali 10 ~ 20 parts, RADIX POLYGONI MULTIFLORI PREPARATA 10 ~ 15 parts, thizoma curculiginis 10 ~ 15 parts, radish 10 ~ 15 parts, the fruit of glossy privet 10 ~ 15 parts, the root of herbaceous peony 10 ~ 15 parts, giant knotweed 10 ~ 15 parts, 10 ~ 15 parts, sophora flower.

For solving the problems of the technologies described above, the present invention also provides the preparation method of a kind of parasitic loranthus health protection tea of hypertension and hyperlipemia, and described in it, the preparation process of parasitic loranthus health protection tea comprises following aspect:

A. the preparation of parasitic loranthus;

B. heating in all the other raw material soaking ethanol described is extracted into medicinal extract;

C. again the medicinal extract that all the other raw materials extract is condensed into granule, pulvis or paste;

D. concentrated granule, pulvis or paste are mixed with the parasitic loranthus prepared, sterilizing is prepared into health care medicinal tea.

In described step a, parasitic loranthus can be tapped to time spring in the winter time, remove thick stem, segment, dry, or dry after steaming.

In described step b, all the other raw materials can be got and clean impurity elimination, add in the ethanol accounting for its quality 5-10 times amount and soak 1-2 hour, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extract, 100-120 order filters, then is the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, when ultrafiltrate reduced pressure concentration relative density is 80 DEG C 1.36 medicinal extract, stand for standby use.

In described step c, the medicinal extract that above-mentioned steps obtains can be inserted in economic benefits and social benefits vacuum concentrator, when being concentrated into 80 DEG C, relative density is the medicinal extract of 1.50, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Refrigeration liquid is added the filter aid diatomite of 0.3%, filter, medicinal extract is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 0.5g crude drug amount; Paste after concentrated adds dextrin mediation and makes granule; Or convection drying makes pulvis.

In described steps d, the granule of the parasitic loranthus made and other raw materials of refinement, pulvis or paste can be mixed, pack after ultraviolet ray sterilization bactericidal.

For solving the problems of the technologies described above, the present invention reoffers the preparation method of a kind of parasitic loranthus health protection tea of hypertension and hyperlipemia, it is characterized in that, its preparation process can also be:

A. the preparation of parasitic loranthus, as component 1;

B. all the other bulk drugs described are extracted as component 2;

C. component 1 and component 2 are mixed, add the mediation of appropriate propolis after concentrated and granulate, bottle after ultraviolet ray sterilization bactericidal.

In described step a, parasitic loranthus can be tapped to time spring in the winter time, remove thick stem, segment, dry, or dry after steaming; Put into iron pan slow fire to stir-fry 10-15 minute; The parasitic loranthus of having fried to be steeped in ethanol after 1-2 days, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extract, 100-110 order filters, be the ultrafiltration post ultrafiltration of 6000-10000 again through the molecular weight that dams, when ultrafiltrate reduced pressure concentration relative density is 80 DEG C 1.36 medicinal extract, stand for standby use, become component 1; In described step b, all the other raw medicinal materials can be mixed, all the other raw materials be put into the ethanol accounting for its quality 10 times amount and soak more than 24 hours, heating and refluxing extraction 2 times, each 1 ~ 2 hour, No. 2 extracts be merged and leaves standstill; The dregs of a decoction of the medicinal material crossed by above-mentioned alcohol extract again add the water heating and refluxing extraction 2 times accounting for its quality 10 times amount, each 1 ~ 2 hour, are merged by No. 2 extracts and leave standstill; Above-mentioned two kinds of extracts are merged, as component 2; In described step c, can blending ingredients 1 and component 2, after reclaiming ethanol, decompression is put into inspissator and is concentrated, and by gained concentrate adjustment proportion to 1.46, decompression, the paste after concentrated adds propolis or dextrin and is in harmonious proportion and granulates, and bottles after ultraviolet ray sterilization bactericidal.

The technique effect that the present invention is useful is, parasitic loranthus is sweet in flavor and cold in property, enters lung, liver, kidney channel.Property get a breathing space and, can rise and can fall.Can filling liver kidney, strengthening the bones and muscles, wines used as antirheumatic.These product have hypotensive effect again.The hypotensive tea of Chinese medicine of the present invention solves hypertension problem from basic, is that temporary the reducing blood pressure of hemangiectasis improves symptom, the mechanism that the present invention is hypotensive: fat eliminating unlike Western medicine, promote blood circulation, softening blood vessel, diuresis, toxin expelling, decompression is that the basic reason produced from hypertension is started with, hypotensive very lasting, and, the dizziness that hypertension and hypotensive Western medicine bring can also be eliminated simultaneously, headache, feel sick, poor appetite, oedema etc. are not disease symptoms.The hypotensive curative effect of Chinese medicine is lasting, and safety is reliably, nontoxic, is worth promoting.

Detailed description of the invention

Most of hypertension case does not have the single or specific cause of disease, and this situation is considered to idiopathic, and be the interactional result of h and E, hereditation is within the scope of 30%-60% according to estimates.Essential hypertension majority is polygenes dysfunction, and wherein each gene pairs blood pressure has sub-fraction effect.Environmental factor certainly plays a role, and the interaction of itself and several genes can make blood pressure tilt distribution be offset to higher level.H and E factor, by what approach raising blood pressure, is illustrated at present not yet completely.From blood pressure aerodynamic point, blood pressure=CO × peripheral resistance, therefore, the factor affecting these two aspects all take part in hypertensive generation, comparatively concentrates on following link: 1) the kidney retention of sodium salt, and too much sodium salt is by renal reabsorption, circulation volume increases, body makes excessive tissue pour into for avoiding cardiac output to increase, and SR parteriole shrinks and strengthens, and peripheral vascular resistance increases.2) inner skin cell function imbalance, endothelial cell is considered to the source that material is shunk in multiple diastole, the smooth muscle cell below it is had to the paracrine impact of local.The vasodilator reaction mediated as nitric oxide (nitrogenmonoxidum, NO) is impaired may promote abnormal vascular remodeling; Endothelin-1 can cause strong and lasting vessel retraction, and its ARBs can improve the endothelium-dependent vasodilatation of hyperpietic.3) sympathetic activity is hyperfunction, and sympathetic activation patient catecholamine levels raises, by separately or with the synergy that catecholamine stimulates renin release, shrink parteriole, increase CO or change normal kidney pressure volume relationship.4) RAS, the all functions of feritin are all completed by synthesis Ang II, Ang II and angiotensinconverting enzyme (angiotensin II1 typereceptor, AT1R) combine, direct contraction parteriole, and by stimulating Aldosterone Secretion to increase CBV.5) insulin resistance, insulin resistance is the common pathophysiological basis that diabetes B and hypertension occur, and insulin resistance causes Secondary cases hyperinsulinemia, makes sympathetic activity hyperfunction, and can increase kidney sodium salt and heavily absorb.

In the Chinese ten large causes of death, the death rate relevant to metabolic disease is just up to 35.7%, and the death toll relevant to " three is high " also accounts for 27% of total death toll.High fat of blood can cause blood vessel embolism; Hypertension can cause cerebral hemorrhage and rupture of blood vessel in brain; Hyperglycaemia can cause diabetes.The World Health Organization once clearly proposed, and prevented the first line of defence of cardiovascular disease from reducing " three is high " exactly and controlling " three is high ".A lot of diabetes patient is with hyperlipidemia, and therefore diabetes and hyperlipidemia, people call that sister is sick usually, and think that high fat of blood is the secondary disease of diabetes.The diabetic of about 40% has disorders of lipid metabolism according to statistics.Be characterized in that triglycerides increases to reduce with HDL.When the reason that diabetes cause blood fat to increase is due to diabetes patient's insufficient insulin, body lactonase activity lowers, and therefore easily blood fat increases.Diabetes itself also accompany fat, protein and water, dielectric disorder except carbohydrate metabolism disturbance simultaneously on the other hand.Often there is free fatty to mobilize out from fat depot, triglycerides and FFA concentrations in blood are increased.Diabetes B people takes food too much on the one hand again, and motion is few, and impel lipid synthesis in body to increase, this is also the reason causing blood fat to increase.And fat companion's high fat of blood person, because insulin receptor number reduces relatively, thus produce insulin resistance, easy induced Diabetic.Blood fat increased perosn also easily causes the heart, cerebrovascular complication.

Day by day flourishing due to economy, the continuous lifting of modern's living standard, cause people too much have deep love for enjoy, do not notice that the life style of oneself, behavioural habits, diet are had a liking for, thus the disease caused.Society with fast rhythm lives, the operating pressure of keen competition, serious threat is caused to the physical and mental health of modern, people more than half is made to be in sub-health state, show as: dizzy, nervous, weak, poor appetite, failure of memory, insomnia, indifferent to etc. to thing, in addition, long-term diet is unreasonable, that is: smart grain replaces coarse food grain completely, a large amount of three height (high heat, high protein, higher fatty acid), more than three, (anticorrisive agent is many, flavoring agent is many, hormone is many) agricultural chemicals residual in the absorption of food and food, chemical fertilizer stockpiling in vivo, add air, pollution of waterhead and amount of exercise less than normal, go down to make three high disease (hypertension for a long time like this, hyperglycaemia, high fat of blood), cardiovascular and cerebrovascular disease, cancers etc. so-called " modern civilization diseases " rise rapidly, and constantly rejuvenation, the serious health and lives jeopardizing the mankind.A variety of causes makes immune system normally can not play protective effect, and in the case, very easily cause the infection such as bacterium, virus, fungi, therefore hypoimmunity the most directly shows is exactly liable to illness.

Pharmacological action

One diuresis

Two hypotensive effects

Three antivirus actions

The red sage root is bitter, is slightly cold.The thoughts of returning home, Liver Channel.Stasis-dispelling and pain-killing, activating blood to promote menstruation, clear away heart-fire relieving restlessness.For irregular menstruation, through closing dysmenorrhoea, a lump in the abdomen causing distension and pain, and chest ventral spine pain, hot numbness pain, sore swells and ache, dysphoria and insomnia.For sternal rib hypochondriac pain, arthralgia due to wind-dampness, abdominal mass lumps, and sore swells and ache, fall fall forward grieved, irregular menstruation, through closing dysmenorrhoea, postpartum stasis of blood pain etc.Treatment sternal rib pain, abdominal mass caking, and irregular menstruation, through amenorrhoea pain, there is good effect." detailed outline " carries: the red sage root, and by " the sensible opinion of married woman " cloud, gynecopathy controlled by Siwu Tang, pays no attention to antenatal postpartum, how many through water, all can be general, and the only taste red sage root falls apart, and cures mainly identical with it.The lid red sage root can break place blood, mends new blood, peaceful tire, and fall stillborn foetus, only metrorrhagia stagnant under, menstruation regulating arteries and veins.Main Compositions of Radix Salviae Miltiorrhizae tanshinone has hemangiectasis, improves circulation, removes the effects such as intravascular coagulation, has effect of invigorating blood circulation trace, and can promote that liver blood circulates, be beneficial to liver cell regeneration.

Poria cocos taste is sweet, light, property is put down, and is used as medicine and has the function of clearing damp and promoting diuresis, beneficial spleen and stomach, antitoxic heart-soothing and sedative.Modern medicine study: Poria cocos energy enhanced machine body immunity function, pachymaran has significantly antitumor and protect the liver dirty effect.Poria cocos slightly sweet flavor is put down, and enters the heart, lung, the spleen channel.There is eliminating dampness and diuresis, strengthening the spleen and stomach, effect of antitoxic heart-soothing and sedative.Can control difficult urination, oedema turgor, phlegm and retained fluid is coughed inverse, vomits inverse, and vomiting during early pregnancy, has loose bowels, seminal emission, stranguria with turbid discharge, palpitation with fear, forgetful disease such as grade.The Li Shui of Poria cocos, is reached by strong fortune spleen PFT, different from the Chinese medicine of other direct Li Shui.For splenasthenic diarrhea, the lower Poria cocos of band can invigorating the spleen, again can excreting dampness, and for having loose bowels caused by insufficiency of the spleen dysfunction of the spleen in transportation and transformation, being with down, application Poria cocos has the effect of giving consideration to both the incidental and fundamental, the compatibilities such as normal and Radix Codonopsis, the bighead atractylodes rhizome, Chinese yam.Can be used as tonifying lung spleen, control the adjuvant of the deficiency of vital energy.

The Chinese medicine fleece-flower root have Radix Polygoni Multiflori and RADIX POLYGONI MULTIFLORI PREPARATA point, direct slicing is used as medicine for Radix Polygoni Multiflori, dries be used as medicine for RADIX POLYGONI MULTIFLORI PREPARATA with black soya bean liquor after mixing steaming.The function of the two is different: the removing toxic substances of Radix Polygoni Multiflori function, the carbuncle that disappears, relax bowel, and is usually used in treatment scrofula sore carbuncle, rubella itch, the dry constipation of intestines; The filling liver kidney of RADIX POLYGONI MULTIFLORI PREPARATA function, benefiting essence-blood, black beard and hair, strengthening the bones and muscles, under sallow for the deficiency of blood, dizzy tinnitus, poliosis, soreness and weakness of waist and knees, extremity numbness, uterine bleeding band, chronic malaria body is empty etc.RADIX POLYGONI MULTIFLORI PREPARATA of the present invention is the good merchantable brand of invigrating kidney.

Thizoma curculiginis have tonify the kidney and support yang, benefiting essence-blood, strengthening the bones and muscles and promoting circulation of blood detumescence effect, be mainly used in the illnesss such as the insufficiency of the kidney yang, impotence and seminal emission, consumptive disease internal injury and arthralgia and myalgia.Kidney-replenishing, strengthening the bones and muscles, loose cold-dampness.Control impotence cold sperm, aconuresis, uterine bleeding, trusted subordinate's crymodynia, cold arthralgia of loins and legs, ulcer, scrofula, the deficiency of yang is cold rushes down.Impotence essence is cold, the diseases such as waist knee is air-cooled, muscles and bones impotence numbness.Have thizoma curculiginis ball in ancient prescription, can strengthen the bone, benefit spirit, improving eyesight, black beard and hair." Haiyao Bencao, Oversea Materia Medica ": main air, mend warm waist pin, clear five viscera settling, strengthening the bones and muscles, helps digestion.Declare and mend again, main husband's seven kinds of impairments, improve visual and auditory acuity, beneficial biceps, filling out marrow, Yiyang." Japan hanako materia medica ": control all general mood, mends general debility, the lower gas of appetizing.

The root of herbaceous peony is cool in nature, and bitter acid, is slightly cold, has soft liver of enriching blood, flat liver pain relieving.Astringe yin receives the effects such as sweat, is applicable to fever due to yin deficiency, irregular menstruation, chest abdomen pain over the hypochondriac region, four limbs contraction suddenly, rushes down dysentery stomachache, spontaneous sweating, uterine bleeding, the inferior disease of band.Paeoniflorin has antibacterial, antipyretic, anti-inflammatory, increase coronary flow, improves the effect of myocardial nutritional flow, hemangiectasis, antagonism acute myocardial ischemia, Antiaggregating activity on platelet, calmness, analgesia, spasmolysis, antiulcer, adjustment blood sugar.Root of herbaceous peony decoction can suppress shigella dysenteriae, streptococcus pneumonia, Escherichia coli, typhoid bacillus, hemolytic streptococcus, Pseudomonas aeruginosa etc.The deficiency of blood deficiency of Yin, chest abdomen pain over the hypochondriac region, pain in the hepatic region, cholecystitis, gallstone pain, to rush down the condition subject such as dysentery stomachache, women's menalgia, spontaneous perspiration easy sweat night sweat, systremma, spasm of limbs pain, uneasy leg syndrome suitable edible.

Giant knotweed is clearing heat and detoxicating, normalizing gallbladder to cure jaundice, expelling wind and removing dampness, loose stasis of blood analgesic therapy, relieving cough and reducing sputum.For joint pain, jaundice with damp-heat pathogen, through closing, postpartum blood stasis not under, leprosy lump in the abdomen, coughing with a lot of sputum, scald, traumatic injury, carbuncle sore tumefacting virus.Giant knotweed contains knotweed glucoside, organic acid, glycoside, polysaccharide etc.Having clearing heat and detoxicating, cooling and heatstroke-eliminating, stomach invigorating food effect clearly, is a kind of polygonaceae plant.

Ligusticum wallichii enters liver, spleen, three burnt three warps.Function cures mainly activating QI to alleviate the depression, and method wind-dryness is wet, promoting blood circulation and stopping pain.Controlling air-cooled headache revolves dizzy, hypochondriac pain abdomen ache, arthritis muscle contraction, through closing, difficult labour, postpartum stasis blocking block pain, ulcer sores.For irregular menstruation, through closing dysmenorrhoea, lump in the abdomen is suffered from abdominal pain, the shouting pain of the chest side of body, tumbling and swelling, headache, arthralgia due to wind-dampness." detailed outline " carries: " eliminating dampness, antidiarrheal dysentery, activating QI to alleviate the depression." ligustrazine removes vascular smooth muscle (aortic article) spasm (adrenaline, potassium chloride cause).Can also coronary vasodilator be expanded, increase CF.The myocardial ischemia-anoxemia that antagonism pituitrin causes.Alleviate the myocardial infarction lesion degree that ligation coronary artery causes.

The fruit of glossy privet, sweet-bitter flavor, cool in nature, return liver kidney channel, there is the merit that nourishing liver and kidney, beneficial the moon nourishes blood.Modern medicine study proves, the fruit of glossy privet includes ursolic acid, sweet mellow wine, glucose, fatty wet goods, has cardiac stimulant, diuresis and hepatoprotective effect, the leucocyte decline quantity caused because of chemotherapy can be made to raise, and have inhibitory action to staphylococcus aureus, Escherichia coli.The acid of the oleanolic acid fruit of glossy privet, Ligustrum lucidum Ait, ursolic acid, stearic acid, oleic acid, sweet mellow wine, betulin, phosphatide and carbohydrate is contained as Fructus Ligustri Lucidi polysaccharide, arabinose, glucose etc. in the fruit of glossy privet, also containing 15 seed amino acids, 11 kinds of trace elements and volatilization wet goods.Research thinks that the fruit of glossy privet has hypoglycemic and reducing blood lipid and has study of anti-atherogenic effect, and antibacterial, antivirus action in addition, fruit of glossy privet decoction all has inhibitory action to staphylococcus aureus, shigella flexneri, typhoid bacillus, Pseudomonas aeruginosa and Escherichia coli.Medium degree inhibitory action is had to Type B adenovirus.Increasing leukocyte: the fruit of glossy privet and component preparation thereof all have certain influence to haemocyte, it declines to leucocyte caused by chemotherapy rising effect.Compound containing the fruit of glossy privet also has effect in increasing leukocyte.Anti thrombotic action: oleanolic acid can accelerate the mobility of platelet cell, reduce the collision between blood platelet, make it not easily adhesion and gathering, more not easily deposit at endangium, slow down or prevent thrombosis, the deposition of lipid inner membrance can be reduced again, for the thrombotic diseases preventing and treating the elderly provides part Experiment foundation.Anti-ageing raising immunity: fruit of glossy privet decoction can make mouse immune organ thymus gland, spleen weight increase; Significantly improve mice serum hemolytic antibody active, impact mouse spleen lymphocyte being produced to proleulzin has dual regulation.The fruit of glossy privet has significant immunological enhancement, scavenging free radicals thus anti-ageing.Application fruit of glossy privet control: angiocardiopathy, coronary heart disease, hyperlipidemia, diabetes, thrombopenia, leukopenia, chronic nephritis, chronic bronchitis, intractable aypnia, Chronic Benzene Poisoning, tumour, malnutrition, immunologic hypofunction disease, seborrhea

The root bark of white mulberry: the alcohol extract 5 ~ 6mg/kg of the root bark of white mulberry, to the decline that anesthetized rabbit, dog duodenal administration can make animal blood pressure obvious and lasting.And oral to the animal 20g/kg of experimental renal hypertension, also can produce obvious hypotensive effect.Cut off both sides vagus nerve or cut off spinal cord in 5th ~ 6 cervical vertebras, its hypotensive effect is constant.The extract of root bark of white mulberry ether, hot water or warm methyl alcohol, during to rabbit hemostasis 1g (crude drug)/kg, can make blood pressure decline 2 ~ 3.3kPa.A kind of material [fusing point (decomposition) is 144 DEG C] is raised from the root bark of white mulberry, to rabbits after intravenous note 10mg/kg, blood pressure significantly declines immediately, cuts off neck vagus nerve or cervical vertebra, this effect still exists, therefore infers that in extract may be acetylcholine sample material.Mulberry bark extract can suppress isolated frog heart, excited rabbits infestines, and the effect of reducing blood pressure can be resisted by atropine.Point out this kind of step-down to suppress, may inhibit vasomotor center and occur, step-down seemingly has increase to renal blood flow simultaneously.Isolated sanggenon quiet note rabbit from the root bark of white mulberry, can significantly step-down, and cyclomorusin, mulberry skin furans C etc. have hypotensive effect.

Selfheal (Classification system: Prunella vulgaris), also known as iron look grass.Bitter, acrid, cold.Enter liver, gallbladder channel.To relieve inflammation or internal heat improving eyesight: control red eye, swell pain, headache.Clearing away the liver-fire, hypotensive: to control the sticky and hyperglycaemia of high blood pressure, high fat of blood, high blood.Mass dissipating and swelling eliminating: control scrofula, goiter and tumor, acute mastitis swell and ache.Function cures mainly clearing liver, dissipating bind, diuresis; Control the diseases such as seasonal febrile diseases, acute mastitis, order pain, jaundice, gonorrhoea, hypertension; Leaf can for tea.Control scrofula, Thyroid Gland Swell, scrofula, goiter and tumor, acute mastitis, breast cancer, order pearl nyctalgia, photophobia are shed tears, under vertigo, facial paralysis, arthralgia and myalgia, pulmonary tuberculosis, acute icteric catarrhal jaundice, metrorrhagia, band.

Yncaria stem with hooks is cool in nature, and taste is sweet.The flat liver of function heat-clearing, dispelling wind and relieving convulsion.For dizzy, the dysphoric cold of having a headache, frightened dysentery tic, pregnant sub-dysentery, vascular hypertension." detailed outline " carries it: " yncaria stem with hooks, hand, foot faint cloudy medicine also.Foot is fainted cloudy main air, and hand is fainted cloudy main fire, the frightened dizzy fortune of epilepsy, all disease of liver wind facies fire, and yncaria stem with hooks leads to pericardium in edema with the liver involved, and the quiet fire of wind puts out, then all diseases oneself remove." proving that it has good sedation through test, yncaria stem with hooks decoction 0.1 g/kg, to mouse peritoneal injection, can produce obvious sedation, but without obvious syngignoscism.

The dry mature seed that cassia seed (formal name used at school: Catsia tora Linn) is pulse family annual herb plant Cassia tora or little Cassia tora.Cassia seed is also Cassia occidentalis.Cassia seed is annual suffruticose draft; The brightly yellowish look of Cassia tora, pod is elongated, four prism type; Little Cassia tora plant is less, and pod is shorter, is one of important composition.Have the merit of improving eyesight fat-reducing with it and name it.Cassia seed bitter, sweet, one-tenth, cold nature, enters liver, kidney, large intestine channel; Relax bowel, lipopenicillinase improving eyesight, treatment constipation and high fat of blood, hypertension.Clear liver and improve vision, sharp water defaecation, has laxative action, reducing blood pressure and blood fat.

The Radix Astragali has the effects such as invigorating qi for strengthening superficies, sharp water detumescence, pus draining and toxin expelling, myogenic.The history of medicinal existing more than 2000 year so far of the Radix Astragali, modern study, the Radix Astragali is containing the various trace elements such as saponin, sucrose, polysaccharide, several amino acids, folic acid and selenium, zinc, copper.Have enhanced machine body immunity function, protect the liver, diuresis, anti-ageing, resisting stress, step-down and antibacterial action more widely.But table is real evil to be contained, retention of dampness due to stagnation of QI, and dyspepsia is stagnated, ulcer from the beginning of or the real example such as routed after heat poison Shang Sheng.The Radix Astragali has invigorating qi for strengthening superficies, diuresis holder poison, apocenosis, effect of expelling pus and promoting granulation.Weak for the deficiency of vital energy, anorexia and loose stool, the sinking of qi of middle-jiao, rushes down prolapse of the anus for a long time, uterine bleeding of having blood in stool, exterior deficiency spontaneous perspiration, and ulcer difficulty is burst, and burst for a long time and do not hold back, the deficiency of blood is sallow, and interior heat is quenched one's thirst." herbal classic " is recorded: " main ulcer, loses sore for a long time, apocenosis pain relieving.Qi-restoratives, children's's all kinds of diseases and ailments." " Japan hanako materia medica " record: " help gas to strengthen the bone, put on flesh and enrich blood.”

Radish, formal name used at school Raphanus sativus L, Chinese people claims radish.Disappear stagnant, heat of reducing phlegm, lower gas, in wide, removing toxic substances.Control dyspepsia turgor, phlegm is coughed aphonia, and spit blood, bleeding from five sense organs or subcutaneous tissue, quenches one's thirst, dysentery, migraine and general headache." not Lu ": " main sharp the five internal organs, beneficial rational diet gas." Tang Materia Medica: " loose clothes and big gun boil to be taken, and descend gas greatly, disappear paddy, goes phlegm addiction; Raw juice of smashing takes, and master quenches one's thirst." Meng numerous: " very sharp joint, except the five internal organs apoplexy, practices bad odor in the five internal organs.″

The sophora flower traditional Chinese medical science thinks its bitter, cold nature, returns liver, large intestine channel; Enter blood to hold back and fall, body slightly falls apart; There is cooling blood and hemostasis, effect of clearing liver-fire; Cure mainly hematochezia, hemorrhoid blood, bloody flux, hematuria, blood drenches, uterine bleeding, spits blood, bleeding from five sense organs or subcutaneous tissue, and irascibility is had a headache, red eye, swell pain, larynx numbness, aphonia, ulcer sores.And from the angle of doctor trained in Western medicine, sophora flower is containing materials such as rutin (i.e. rutin sophorin, Rytub), Quercetin (Quercetin), tannin, sophoradiol (sophoradiol), vitamin As.Rutin can improve the function of capillary, and keep the normal resistance of capillary, prevent because capillary fragility is excessive, too high hemorrhage, hypertension, the diabetes caused of permeability, can preventing of clothes is hemorrhage.

Specific embodiment 1:

Winter taps parasitic loranthus to time spring, removes thick stem, segment, dry, or dry after steaming.

Again by all the other raw material yncaria stems with hooks, selfheal, the root bark of white mulberry, cassia seed, Poria cocos, the red sage root, Ligusticum wallichii, the Radix Astragali, RADIX POLYGONI MULTIFLORI PREPARATA, thizoma curculiginis, radish, the fruit of glossy privet, the root of herbaceous peony, giant knotweed, sophora flower, extracts, makes paste, granule or pulvis.

The paste of the parasitic loranthus prepared and extract, granule or pulvis are mixed, ultraviolet radiation for sterilizing and disinfecting packs.

Specific embodiment 2:

Winter taps parasitic loranthus to time spring, removes thick stem, segment, dry, or dry after steaming.Large with block, meat is thick, be good without core and impurity person, iron pan slow fire can be put into and to stir-fry 10-15 minute, about 5000g.

Get other raw material yncaria stems with hooks 1500g again, selfheal 1500g, root bark of white mulberry 1500g, cassia seed 1500g, Poria cocos 1500g, red sage root 1500g, Ligusticum wallichii 1500g, Radix Astragali 1500g, RADIX POLYGONI MULTIFLORI PREPARATA 1500g, thizoma curculiginis 1500g, the sub-1500g of radish, fruit of glossy privet 1500g, root of herbaceous peony 1500g, giant knotweed 1500g, sophora flower 1500g, add in the ethanol of 5-10 times amount and soak 1-2 hour, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extract, 100-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate reduced pressure concentration relative density is 80 DEG C 1.36 medicinal extract, heating is concentrated into paste, stand for standby use, insert in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C, relative density is the concentrate of 1.50, set to 0 ~ 5 DEG C of deepfreezes 24 hours, refrigeration liquid is added the filter aid diatomite of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 0.5g crude drug amount, then adds dextrin and is in harmonious proportion, make granule, the parasitic loranthus be mixed with, ultraviolet disinfection, pack and get final product.

Specific embodiment 3:

Winter taps parasitic loranthus to time spring, removes thick stem, segment, dry, or dry after steaming.Large with block, meat is thick, be good without core and impurity person, iron pan slow fire can be put into and to stir-fry 10-15 minute, about 4000g.

Get other raw material yncaria stems with hooks 1100g again, selfheal 1100g, root bark of white mulberry 1100g, cassia seed 1200g, Poria cocos 1200g, red sage root 1100g, Ligusticum wallichii 1200g, Radix Astragali 1200g, RADIX POLYGONI MULTIFLORI PREPARATA 1100g, thizoma curculiginis 1200g, the sub-1100g of radish, fruit of glossy privet 1200g, root of herbaceous peony 1100g, giant knotweed 1100g, sophora flower 1200g, get bulk drug clean dry, in 70 DEG C of baking ovens, dry 1-3h, take out and be placed in cooling in drying box, pulverized 80-100 mesh sieve with pulverizer.The parasitic loranthus be mixed with, ultraviolet disinfection, packs and get final product.

Specific embodiment 4:

Winter taps parasitic loranthus to time spring, removes thick stem, segment, dry, or dry after steaming.Large with block, meat is thick, be good without core and impurity person, iron pan slow fire can be put into and to stir-fry 10-15 minute, about 3000g.

The parasitic loranthus of having fried to be steeped in ethanol after 1-2 days, heating extraction 2 times, each 1-2 hour, removes supernatant, merges extract, 100-110 order filters, be the ultrafiltration post ultrafiltration of 6000-10000 again through the molecular weight that dams, when ultrafiltrate reduced pressure concentration relative density is 80 DEG C 1.36 medicinal extract, heating be concentrated into paste, stand for standby use, becomes component 1, all the other raw medicinal materials are mixed, yncaria stem with hooks 1200g, selfheal 1300g, root bark of white mulberry 1100g, cassia seed 1200g, Poria cocos 1200g, red sage root 1100g, Ligusticum wallichii 1200g, Radix Astragali 1200g, RADIX POLYGONI MULTIFLORI PREPARATA 1100g, thizoma curculiginis 1200g, the sub-1100g of radish, fruit of glossy privet 1200g, root of herbaceous peony 1300g, giant knotweed 1300g, sophora flower 1200g, shredded 100 ~ 120 mesh sieves, after sieving, fine powder is for subsequent use, coarse granule puts into acid and alkali-resistance infusion kettle, at room temperature, 3 ~ 7 days are flooded together with more than 70 degree ethanol, then heating and refluxing extraction 2 times, each 1 ~ 2 hour, No. 2 extracts are merged and leaves standstill, filter, filtrate is got after separation, by filtered through gauze, add 50-60% ethanol in residue, 60 DEG C-70 DEG C are continued lixiviate 2h, and every 10min stirs once, filtered through gauze, and merge leaching liquor, being condensed into pasty state becomes component 2, by component 1 and component 2-in-1 and after, insert in economic benefits and social benefits vacuum concentrator, when being concentrated into 80 DEG C, relative density is the medicinal extract of 1.60, and the paste after concentrated adds propolis or dextrin and is in harmonious proportion and granulates, and packs after ultraviolet ray sterilization bactericidal.

Pharmacological toxicity is tested

Experimental example 1: acute toxicity test of the present invention

One, test material: animal: Kunming mouse, body weight 18-25g, male and female half and half, Shandong University's biology laboratory breeding.Medicine: the present invention's (all raw material mixing decoction 2 times merges and filters, taking liquid) is containing 0.0365mg/mi.

Two, method:

1, LD50 calculates: adopt improvement karber's method, mouse is divided into 5 groups at random, often organize 10, male and female half and half, dissolve adding distil water of the present invention, are made into Cmax, by the administration of mouse maximum permission capacity, institute is followed successively by 18,14.4 to dosage by crude drug amount, 11.5,9.2,7.4 (g.kg-1), in animal fasting (can't help water) after 18 hours, administration at twice in one day (interval half an hour), each 0.5ml, observes animal dead situation.

2, maximum tolerated dose measures (MTD value): get mouse 20, each 10 of male and female.Adding distil water of the present invention is dissolved, is made into maximum concentration, by the maximal tolerance dose of animal, feed device and can twitch to inject to fill with and be as the criterion.In animal fasting (can't help water) after 18 hours, administration at twice in one day (interval half an hour), each 0.5ml (every ml containing crude drug 0.36g), total dose is 18g crude drug/kg.d, 300 times of quite clinical adult 50Kg body weight consumption.Continuous Observation 7 days after administration.

Three, result of the test:

In LD50 calculates when giving mouse with maximum acceptable concentration and maximum permission capacity (18g/Kg.d), have no dead mouse, namely LD50 is not measured, ask maximum tolerated dose only, in 7 day observation period, its appetite of animal, activity, hair color, the state of mind etc. are all normal, grow normal, there are no death.Namely select the 300 times of doses being equivalent to clinical dosage, and have no adverse reaction, show that acute toxicity is minimum, MTD > 18g/Kg.d.

Experimental example 2: the result of the test of acute toxicity and long term toxicity

Acute toxicity test: give the present invention by the disposable gavage of small white mouse, maximum concentration 35%, maximum gavage capacity 0.4ml/10g, dosage 14g/kg (every g medicinal powder is equivalent to 10g crude drug), Continuous Observation 7 days, do not find any toxic reaction, because concentration and dosage cannot increase, therefore fail to measure the LD 50 of this medicine.Maximum tolerance determination: with maximum concentration, maximum gavage capacity, mice lavage administration 3 times, 5 hours, interval, then Continuous Observation 7 days, none example is dead.Medicinal powder dosage is > 42g/kg. day (every g medicinal powder is equivalent to 10g crude drug), calculates 420 times of the clinical consumption per day that is equivalent to be grown up by kg body weight.

Long term toxicity test: whether produce toxic reaction for observing long-term prescription, give rat the present invention respectively and raise clothes, by adult 70 times of clinical consumption per day and 35 times (i.e. 7g/kg/ day and 3.5g/kg/ day), give continuously and feed 8 weeks, have no the behavior of rat, feed, body weight appearance extremely, with control group ratio, routine blood test, hepatic and renal function, the change all without exception of various important organ, within the scope of institute's dosage, do not find any toxicity of the present invention.Confirmed by the acute and chronic toxicity test of animal, safe range of the present invention is comparatively large, is a kind of safe and reliable health products.

Pharmacological experiment:

Hypertension is the hazards causing cardiovascular and cerebrovascular disease important, is the modal chronic disease of global human, and actively preventing and treating hypertension is extensively concerned important topic.Hypertensive pathogenesis is complicated, illustrates not yet completely so far.In recent years, the non-selective cation channel on a kind of cell membrane, transient receptor potential channel C subfamily (transient receptorpotential canonical, TRPC) and hypertensive correlation are just becoming the focus of research.TRPC channel organization is widely distributed, regulates by many factors, wide participation cardiovascular pathology physiology course.Research finds, transient receptor potential channel C subtribe 3 hypotype (TRPC3) and 6 hypotypes (TRPC6) are close with Relationship between Essential Hypertension, mechanism of action and the traditional pathogenesis of hypertension distinct.But, at present about the research of antihypertensive drugs to TRPC pass effect just just starts.This research is intended to understand spontaneous hypertensive rat (spontaneouslyhypertensive rats, SHR) expression of sustainer TRPC3 and TRPC6, after the present invention, Valsartan and amlodipine in treatment SHR rat, observe change expressed by medicine impact on TRPC3 and TRPC6, Primary Study TRPC3 and TRPC6 regulates and controls the mechanism of blood pressure, finds better therapy target provide experimental basis for clinical prevention hypertension.

1 materials and methods

1.1 material

1.1.1 animal used as test

Healthy SHR and WKY rat, 12 weeks, male, body weight 240-280g, purchased from institute of lab animals of China Concord Medical Science University of the Chinese Academy of Medical Sciences, licensing numbering SCXK (capital) 2009-0004, raises in Shandong Medical University's Experimental Animal Center.

1.1.2 main agents and preparation thereof

(1) main agents

Valsartan (Valsartan) Nova Lab SDN. BHD of Ramipril (Rui Tai) Sanofi-Aventis pharmaceutical Co. Ltd Amlodipine Besylate Tablet (Amlodipine Besylate Tablet) pfizer inc TRPC3, TRPC6 Tu Kang polyclonal antibody U.S. Chemicon company's T rizol Reagent American I nvitrogen Reverse Transcription box ReverTra Ace-α-Japanese TOYOBO Membrane protein extraction kit shellfish is won Bo Aosen Bioisystech Co., Ltd BCA determination of protein concentration kit Beijing, biological Co., Ltd GAPDH rabbit anti-monoclonal antibody Beijing Bo Aosen Bioisystech Co., Ltd horseradish enzyme labeling goat anti-rabbit igg Beijing Bo Aosen Bioisystech Co., Ltd SDS-PAGE gel and prepares kit Beijing Bo Aosen Bioisystech Co., Ltd

(2) preparation of main agents

4% paraformaldehyde: paraformaldehyde 40g, 1L protein electrophoresis buffer solution is settled to: Tris6.0g with 0.1M PBS buffer solution, glycine 28.8g, SDS1.0g, 1L transferring film buffer solution is settled to: Tris2.375g by deionized water, glycine 11.25g, SDS0.375g, methyl alcohol 200ml, deionized water is settled to 1LTBS buffer solution: NaCl 8.0g, KCl 0.2g, Tris 3.0g, distilled water is settled to 1LTBST buffer solution: TBS buffer solution 700ml, 20% Tween-20 1.65ml confining liquid: skimmed milk power 5g, TBST (0.01%) 100ml.

1.1.3 key instrument and equipment

Rat tail artery non-invasive blood pressure measuring RBP-1 type, Huaibei Zheng Hua bio-instruments Co., Ltd high speed freezing centrifuge Allegra 64R type, U.S. Beckman inverted microscope Japan OLYMPUS gel/luminescence image analysis system ChemiDOC-X-RS type, U.S. Bio-Rad ultra-pure water instrument ELIX10 type, U.S. Minipore grads PCR instrument S1000 double flute, U.S.'s Bio-Rad all-wave long ELIASA MSS type, Finland's thunder vigorous ultra low temperature freezer MDF-382HT type, Japan Sanyo micro centrifuge Micro17 type, U.S. Thermo, electronic analytical balance AUW120D type, Japan's Shimadzu, three use electric heat constant temp. water tank KW-1000DA type, Community of Jin Tan County city gold is laboratory apparatus factory.Autoclave LAC-5060S type, Korea S's Lay is rich carries relaxation constant-temperature table 420 class, U.S. Thermo electric heating constant-temperature blowing drying box DHG-9140A type, Shanghai Qi Xin scientific instrument Co., Ltd.Electrophoresis apparatus DYY-10C type, Beijing Liuyi Instrument Factory's Vertial electrophorestic tank.U.S. Bio-Rad Desk type refrigeration constant-temperatureoscillator shaking table SHA-2 type, Community of Jin Tan County city gold is laboratory apparatus factory.722 ultraviolet light spectrophotometer UV-265 types, Japanese Shimadzu

1.2 experimental technique

1.2.1 animal grouping and administration

24 12 week ages, healthy male SHR rat, was divided into 4 groups (n=6): SHR control group, of the present invention group, Valsartan group and Amlodipine group at random.6 12 week age male WKY rat be set to Normal group,

Totally 5 groups.Medication therapy groups uses the present invention (1mg/kg.d respectively, the present invention extracts former medicine and is dissolved in physiological saline), Valsartan (30mg/kg.d, the former medicine of Valsartan is dissolved in physiological saline), Amlodipine (5mg/kg.d, the former medicine of Amlodipine Besylate Tablet is dissolved in physiological saline) gavage 4 weeks.WKY control group, SHR control group give normal saline gavage 4 weeks.

1.2.2 animal blood pressure measures

Rat systolic pressure before and after drug therapy is measured with tail cover method analysis of blood pressure device.Rat, under waking state, is placed in 38 DEG C of insulating boxs after 10 minutes, and be fixed on and measure in case, mouse tail is through tail cover; To tail cover inflating pressure after its peace and quiet, make pulse wave be decreased to disappearance gradually, be then deflated to pulse wave and recover normal completely.Systolic pressure is pressure value corresponding when again there is waveform after pulse blocks, and every duplicate measurements 3 times, averages.

1.2.3 sacrifice of animal and collection of specimens

Rat with after the intraperitoneal anesthesia of 40mg/100g dosage, is fixed on operating desk with 3.5% chloraldurate, opens chest and takes out sustainer (from the arch of aorta to abdominal aortic bifurcation).Bloodstain is cleaned with the sterilizing DEPC water of 4 DEG C of precoolings.Choose the relatively-stationary position of aorta pectoralis epimere and be about 7mm, sample is put into 4% paraformaldehyde and fix, make vascular tissue's paraffin section, for Immunohistochemical detection.All the other samples are cut into fritter and put into cryopreservation tube, in liquid nitrogen after frozen 30min, are transferred to-80 DEG C of Refrigerator stores, detect for RT-PCR, Western blot.DEPC water sterilization enzyme inactivation all used by all experiment appliances, vessel.

1.3 statistical procedures

All data all adopt SAS9.1.3 statistical software to analyze, measurement data represents with mean ± standard deviation (x ± s), between group, mean compares employing variance analysis, and each group is compared between two and use Bonferroni method, and P < 0.05 has statistical significance for difference.

2 results

2.1 blood pressure

SHR control group blood pressure is apparently higher than WKY control group (P < 0.05); Drug therapy is after 4 weeks, and the blood pressure of the present invention, Valsartan group and Amlodipine group obviously reduces, and has statistical significance (P < 0.05) with self comparing before SHR control group and drug therapy; But of the present invention group, difference of blood pressure not statistically significant between Valsartan group and Amlodipine group group.(referring to table 1)

Each group rat systolic pressure (SBP) change (x ± s) before and after table 1 drug therapy

Note: ★ p < 0.05vs is with WKY control group in age in week; ▲ p < 0.05vs SHR control group (16 weeks); ● p < 0.05vs is with before group treatment.

Specific embodiment: journey, female, 60 years old, hypertension 5 years, after Western medicine depressor, just immediately fall too low, people was very uncomfortable, once drug withdrawal just immediately bounce-back.Chinese medicine thinks that mouthfeel is bad, be unwilling to take, children buy commercially available blood-pressure decreasing tea, also whether clearly to have drunk antihypertensive effect, finally use the present invention upon somebody's introduction, the present invention makes through traditional Chinese medicine processing procedure, 8 tank examinations are just bought, coordinate hypotensive Western medicine to drink two weeks, result, blood pressure obviously improves and stabilizes; Finally then drunk 2 months again, blood pressure has been controlled quickly.Again there is not the phenomenon that blood pressure is fluctuated; Drink till now, all within 9 months, in the past blood pressure is always very stable always, and eyes and face also not oedema, head is also not dizzy, and urine volume adds, from head to foot easily.Start to take the present invention always and work as tea-drinking.

The hypotensive tea of Chinese medicine of the present invention solves hypertension problem from basic, is that temporary the reducing blood pressure of hemangiectasis improves symptom, the mechanism that the present invention is hypotensive: fat eliminating unlike Western medicine, promote blood circulation, softening blood vessel, diuresis, toxin expelling, decompression is that the basic reason produced from hypertension is started with, hypotensive very lasting, and, the dizziness that hypertension and hypotensive Western medicine bring can also be eliminated simultaneously, headache, feel sick, poor appetite, oedema etc. are not disease symptoms.The hypotensive curative effect of Chinese medicine is lasting, and safety is reliably, nontoxic, is worth promoting.

Claims

1. the parasitic loranthus health protection tea of a hypertension and hyperlipemia, it is characterized in that, described parasitic loranthus health protection tea comprises the raw material of following parts by weight: parasitic loranthus 10 ~ 50 parts, yncaria stem with hooks 10 ~ 20 parts, selfheal 10 ~ 20 parts, the root bark of white mulberry 10 ~ 20 parts, cassia seed 10 ~ 20 parts, 10 ~ 20 parts, Poria cocos, the red sage root 10 ~ 20 parts, Ligusticum wallichii 10 ~ 20 parts, the Radix Astragali 10 ~ 20 parts, RADIX POLYGONI MULTIFLORI PREPARATA 10 ~ 20 parts, thizoma curculiginis 10 ~ 20 parts, radish 10 ~ 20 parts, the fruit of glossy privet 10 ~ 20 parts, the root of herbaceous peony 10 ~ 20 parts, giant knotweed 10 ~ 20 parts, 10 ~ 20 parts, sophora flower.

2. the parasitic loranthus health protection tea of hypertension and hyperlipemia according to claim 1, it is characterized in that, in described parasitic loranthus health protection tea, the parts by weight of various raw material are: parasitic loranthus 10 ~ 30 parts, yncaria stem with hooks 10 ~ 15 parts, selfheal 10 ~ 15 parts, the root bark of white mulberry 10 ~ 15 parts, cassia seed 10 ~ 15 parts, 10 ~ 15 parts, Poria cocos, the red sage root 10 ~ 15 parts, Ligusticum wallichii 10 ~ 15 parts, the Radix Astragali 10 ~ 15 parts, RADIX POLYGONI MULTIFLORI PREPARATA 10 ~ 20 parts, thizoma curculiginis 10 ~ 20 parts, radish 10 ~ 20 parts, the fruit of glossy privet 10 ~ 20 parts, the root of herbaceous peony 10 ~ 20 parts, giant knotweed 10 ~ 20 parts, 10 ~ 20 parts, sophora flower.

3. the parasitic loranthus health protection tea of hypertension and hyperlipemia according to claim 1, it is characterized in that, in described parasitic loranthus health protection tea, the parts by weight of various raw material are: parasitic loranthus 10 ~ 40 parts, yncaria stem with hooks 10 ~ 20 parts, selfheal 10 ~ 20 parts, the root bark of white mulberry 10 ~ 20 parts, cassia seed 10 ~ 20 parts, 10 ~ 20 parts, Poria cocos, the red sage root 10 ~ 20 parts, Ligusticum wallichii 10 ~ 20 parts, the Radix Astragali 10 ~ 20 parts, RADIX POLYGONI MULTIFLORI PREPARATA 10 ~ 15 parts, thizoma curculiginis 10 ~ 15 parts, radish 10 ~ 15 parts, the fruit of glossy privet 10 ~ 15 parts, the root of herbaceous peony 10 ~ 15 parts, giant knotweed 10 ~ 15 parts, 10 ~ 15 parts, sophora flower.

4. the preparation method of the parasitic loranthus health protection tea of hypertension and hyperlipemia as described in any one of claims 1 to 3 item, it is characterized in that, the preparation process of described parasitic loranthus health protection tea comprises following aspect:

A. the preparation of parasitic loranthus;

5. the preparation method of the parasitic loranthus health protection tea of hypertension and hyperlipemia according to claim 4, is characterized in that, in described step a, winter taps parasitic loranthus to time spring, removes thick stem, segment, dry, or dry after steaming.

6. the preparation method of the parasitic loranthus health protection tea of hypertension and hyperlipemia according to claim 4, is characterized in that, in described step b, get all the other raw materials and clean impurity elimination, add in the ethanol accounting for its quality 5-10 times amount and soak 1-2 hour, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extract, 100-120 order filters, then is the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, when ultrafiltrate reduced pressure concentration relative density is 80 DEG C 1.36 medicinal extract, stand for standby use.

7. the preparation method of the parasitic loranthus health protection tea of hypertension and hyperlipemia according to claim 4, it is characterized in that, in described step c, medicinal extract above-mentioned steps obtained is inserted in economic benefits and social benefits vacuum concentrator, when being concentrated into 80 DEG C, relative density is the medicinal extract of 1.50, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Refrigeration liquid is added the filter aid diatomite of 0.3%, filter, medicinal extract is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 0.5g crude drug amount; Paste after concentrated adds dextrin mediation and makes granule; Or convection drying makes pulvis.

8. the preparation method of the parasitic loranthus health protection tea of hypertension and hyperlipemia according to claim 4, is characterized in that, in described steps d, the granule of the parasitic loranthus made and other raw materials of refinement, pulvis or paste is mixed, packs after ultraviolet ray sterilization bactericidal.

9. the preparation method of the parasitic loranthus health protection tea of hypertension and hyperlipemia according to any one of claims 1 to 3, it is characterized in that, its preparation process can also be:

A. the preparation of parasitic loranthus, as component 1;

B. all the other bulk drugs described are extracted as component 2;

10. the preparation method of the parasitic loranthus health protection tea of hypertension and hyperlipemia according to claim 9, is characterized in that, in described step a, winter taps parasitic loranthus to time spring, removes thick stem, segment, dry, or dry after steaming; Put into iron pan slow fire to stir-fry 10-15 minute; The parasitic loranthus of having fried to be steeped in ethanol after 1-2 days, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extract, 100-110 order filters, be the ultrafiltration post ultrafiltration of 6000-10000 again through the molecular weight that dams, when ultrafiltrate reduced pressure concentration relative density is 80 DEG C 1.36 medicinal extract, stand for standby use, become component 1; In described step b, all the other raw medicinal materials are mixed, all the other raw materials are put into the ethanol accounting for its quality 10 times amount and soak more than 24 hours, heating and refluxing extraction 2 times, each 1 ~ 2 hour, No. 2 extracts are merged and leaves standstill; The dregs of a decoction of the medicinal material crossed by above-mentioned alcohol extract again add the water heating and refluxing extraction 2 times accounting for its quality 10 times amount, each 1 ~ 2 hour, are merged by No. 2 extracts and leave standstill; Above-mentioned two kinds of extracts are merged, as component 2; In described step c, blending ingredients 1 and component 2, reducing pressure after reclaiming ethanol, it is concentrated to put into inspissator, and by gained concentrate adjustment proportion to 1.46, decompression, the paste after concentrated adds propolis or dextrin mediation granulation, bottles after ultraviolet ray sterilization bactericidal.