CN103705596A - Traditional Chinese medicine for reducing blood pressure and preparation method thereof - Google Patents
Traditional Chinese medicine for reducing blood pressure and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine for reducing blood pressure. The traditional Chinese medicine comprises the following traditional Chinese medicines in parts by weight: 5-12 parts of medicines for promoting blood circulation to remove meridian obstruction, 5-10 parts of medicines for nourishing and suppressing Yang, 8-15 parts of diuretic medicines, 5-12 parts of semen cassiae, 4-8 parts of honeysuckle, 2-5 parts of selfheal, 1-5 parts of astragalus membranaceus, 5-8 parts of scaphium scaphigerum and 3-8 parts of hawthorn. According to pathogenesis, pathogeny and complications of hypertension, the traditional Chinese medicines are combined in certain parts by weight, so that not only can the blood pressure reducing effect be remarkable, but also the blood fat adjusting effect is further relatively remarkable, thereby having remarkable meaning for delaying progression of disease and complications of hypertension. The preparation process of the traditional Chinese medicine for reducing blood pressure comprises extraction, filtration and concentration, elution and drying. Not only is the preparation method simple, but also the purity of the traditional Chinese medicine is effectively improved. Meanwhile, a user is prevented from being damaged by various impurities. The medicine provided by the invention is free from toxic and side effects, and especially suitable for hypertensives to use for a long time.
Description
Technical field
The present invention relates to a kind of Chinese medicine, be specifically related to a kind of hypertensive Chinese medicine and preparation method thereof that is used for the treatment of.
Background technology
Hypertension is common a kind of cardiovascular disease, the development of the hypertension state of an illness can cause multiple complications, and the most common is the microangiopathies such as the macroangiopathies such as the heart changes such as left ventricular hypertrophy, coronary heart disease, hemorrhagic and cerebral infarction, arteriosclerosis, retinal arteriosclerosis and optical fundus change.And wherein cerebrovascular disease is a kind of pathological changes the most common in high blood pressure disease evolution, it is also the major reason that causes hyperpietic's death.Change along with people life style, Hypertension incidence increases year by year, the data of announcing according to health ministry show, within 2004, China hyperpietic surpasses 1.6 hundred million, and hyperpietic is still increasing with annual 3500000 people's speed, according to WHO statistics, show, global hyperpietic accounts for the more than 11% of total population.Hypertension is common with middle-older patient, but in recent years, along with the increase of people's life stress and the change of daily life, hyperpietic is rejuvenation more and more.As can be seen here, hypertension has to cause our attention and concern for the threat of human health.
At present, hypertensive western medical treatment is main mainly with enalapril meleate, current enalapril meleate mainly comprises diuretic, vasodilation, alpha-blocking agent, beta-blocker, Angiotensin Ⅱ receptor antagonist and hypertensinase converting enzyme inhibitor etc., hyperpietic need take medicine throughout one's life, but the above-mentioned Western medicine of long-term taking easily produces drug resistance, and can produce injury to patient body, simultaneously, when taking above-mentioned depressor, also easily cause that blood vessel control is unstable, cause fluctuation of blood pressure, cause cerebrovascular disease, bring larger threat to patient's life security.
Hypertension belongs to the traditional Chinese medical science " dizzy " " liver-yang " category, pathogenesis be feelings will internal injury, hepatic and renal YIN deficiency yang hyperactivity or eating and drinking without temperance, the turbid heap soil or fertilizer over and around the roots of expectorant stagnant due to, therefore, during Chinese traditional treatment, should take nourishing YIN and subduing the hyperactivity of liver-YANG or expectorant damp eliminating is Therapeutic Principle.Differential diagnosis in tcm is divided into hyperactivity of YANG due to deficiency of YIN and deficiency of both YIN and YANG amphitypy by hypertension, and traditional Chinese traditional treatment adopts attached osmanthus eight taste pill for curing type of deficiency of YIN leading to hyper activity of YANGs, adopt nourishing YIN Yang Promoting Decoction treatment deficiency of both YIN and YANG type, but treated effect is only 40%-70% left and right.Therefore,, for the current integrative therapy present situation of hypertension, be badly in need of at present finding and to work out a kind of hypertension therapeutic for the treatment of effective, the Chinese medicine preparation that treated effect is high and safe.
Summary of the invention
For solving above-mentioned the deficiencies in the prior art, want, the invention provides a kind of Chinese hypotensor and preparation method,
Technical scheme of the present invention is as follows:
A Chinese hypotensor, described Chinese hypotensor is comprised of the Chinese medicine of following weight portion proportioning:
Described promoting blood circulation to remove obstruction in the collateral class is selected from one or more in Radix Curcumae, Rhizoma Chuanxiong, Rhizoma Corydalis, the Radix Paeoniae Alba or Radix Salviae Miltiorrhizae.
The ratio of the weight portion of described Radix Curcumae, Rhizoma Chuanxiong, Rhizoma Corydalis, the Radix Paeoniae Alba or Radix Salviae Miltiorrhizae is (1-3): (2-5): (1.5-3.5): (1.5-4.5): (2-6).
Described nourishing YIN for suppressing the hyperactive YANG class is selected from one or more in Concha Ostreae or Os Draconis.
The ratio of described Concha Ostreae or the weight portion of Os Draconis is (1.5-5.5): (2-5).
Described diuresis class is selected from one or more in Rhizoma Alismatis, Radix Rehmanniae Preparata, Poria, Folium Nelumbinis or Exocarpium Benincasae.
The ratio of the weight portion of described Rhizoma Alismatis, Radix Rehmanniae Preparata, Poria, Folium Nelumbinis or Exocarpium Benincasae is (1-5): (1-5): (3.5-5.5): (1.5-4.5): (2-4.5).
A preparation method for above-mentioned Chinese hypotensor, comprises the following steps:
(1) take by weight promoting blood circulation to remove obstruction in the collateral class 5-12 part, nourishing YIN for suppressing the hyperactive YANG class 5-10 part, diuresis class 8-15 part, Semen Cassiae 5-12 part, Flos Lonicerae 4-8 part, Spica Prunellae 2-5 part, Radix Astragali 1-5 part, Semen Sterculiae Lychnophorae 5-8 part, Fructus Crataegi 3-8 part, be ground into fine powder, cross 60 mesh sieves, add solvent to extract, obtain extracting solution;
(2) in the extracting solution making in step (1), add solvent to carry out filtering and concentrating, to remove impurity, obtain concentrated solution;
(3) to the concentrated solution making in step (2), adopt macroporous adsorptive resins to carry out eluting, eluting 2 times, obtains eluent;
(4) eluent making in step (3) is dried and makes Chinese medicinal powder;
(5) Chinese medicinal powder making in step (4) is processed, made pill, tablet capsule, slow releasing pill, slow releasing tablet, slow releasing capsule.
Preferably, the solvent described in step (1) is purified water, and the temperature of extraction is 65-80 ℃, and the time of extraction is 30-45min; Solvent described in step (2) is that concentration is the alcoholic solution of 45%-50%, and concentrated temperature is 65-80 ℃, and the concentrated time is 30-45min.
Preferably, the alcoholic solution that the desorbing agent adopting during eluting in step (3) is 20-30%, elution flow rate is 0.6-0.8BV/h, and elution time is 20-30min, and eluting temperature is 50-60 ℃.
Compared with prior art, beneficial effect of the present invention has:
1. hyperpietic is in hypertension, because the course of disease is long, prolonged illness is to deficiency of kidney yin, liver-fire is partially prosperous, and hyperpietic is common with middle-older patient, often with hyperlipidemia, in addition, hyperpietic also easily merges arteriosclerosis, easily there is cerebral hemorrhage or cerebral ischemia, coronary heart disease, the present invention is according to hypertensive morbidity pathogenesis, pathogeny and complications, by promoting blood circulation to remove obstruction in the collateral class, nourishing YIN for suppressing the hyperactive YANG class, diuresis class, Semen Cassiae, Flos Lonicerae, Spica Prunellae, the Radix Astragali, Semen Sterculiae Lychnophorae and Fructus Crataegi compatibility are used, wherein Semen Cassiae has good hypotensive effect, but also there is obvious antiplatelet aggregation, reduce blood viscosity, vascular lesion for prophylaxis of hypertension patient is significant, simultaneously Semen Cassiae also can removing heat from the liver, adjust blood fat.Spica Prunellae has the effect that suppresses renin activity, also plays obvious hypotensive effect.Semen Sterculiae Lychnophorae can eliminate the phlegm in spleen invigorating, and Fructus Crataegi can be adjusted blood fat, and Flos Lonicerae can heat-clearing and toxic substances removing, above-mentioned each medicine compatibility, just hitting hypertensive morbidity pathogenesis and characteristics of incidence, effectively reduce blood pressure, the blood fat that can regulate significantly patient simultaneously, slows down the atherosclerotic generation of patient.
2. the various Chinese medicines in the present invention carry out compatibility according to certain part by weight, have well brought into play the pharmacological action of various Chinese medicines, but also have played good synergism.
3. the various Chinese medicines in the present invention are the general types of the field of Chinese medicines, abundant raw material, in preparation method of the present invention, first extracts Chinese medicine, reconcentration, finally carry out eluting, can effectively remove various impurity in Chinese medicine, not only effectively improved the purity of Chinese medicine, and avoided the infringement of all kinds of impurity to user, and preparation method of the present invention is simple, can make multiple dosage form, meet patient's different demands.
Medicine of the present invention nontoxic, have no side effect, and hyperpietic needs the medication of long-term rule, therefore, the present invention is especially applicable to hyperpietic's long-term taking.
The specific embodiment
Now the present invention is further detailed explanation in conjunction with the embodiments:
Embodiment 1
A Chinese hypotensor, described Chinese hypotensor is comprised of the Chinese medicine of following weight portion proportioning:
Described promoting blood circulation to remove obstruction in the collateral class is Radix Curcumae, and described nourishing YIN for suppressing the hyperactive YANG class is Concha Ostreae, and described diuresis class is Rhizoma Alismatis.
A preparation method for above-mentioned Chinese hypotensor, comprises the following steps:
(1) take by weight 5 parts of promoting blood circulation to remove obstruction in the collateral classes, 5 parts of nourishing YIN for suppressing the hyperactive YANG classes, 8 parts of diuresis classes, 5 parts of Semen Cassiaes, 4 parts of Flos Loniceraes, 2 parts of Spica Prunellaes, 1 part of the Radix Astragali, 5 parts of Semen Sterculiae Lychnophoraes, 3 parts of Fructus Crataegis, be ground into fine powder, cross 60 mesh sieves, add purified water to extract, the temperature of extracting is 65 ℃, the time of extracting is 30min, obtains extracting solution;
(2) in the extracting solution making in step (1), add 45% alcoholic solution solvent to carry out filtering and concentrating, concentrated temperature is 65 ℃, and the concentrated time is 30min, to remove impurity, obtains concentrated solution;
(3) to the concentrated solution making in step (2), adopt macroporous adsorptive resins to carry out eluting, the alcoholic solution that the desorbing agent of employing is 20%, elution flow rate is 0.6BV/h, and elution time is 20min, and eluting temperature is 50 ℃, and eluting 2 times, obtains eluent;
(4) eluent making in step (3) is dried and makes Chinese medicinal powder;
(5) Chinese medicinal powder making in step (4) is processed, made pill.
Embodiment 2
A Chinese hypotensor, described Chinese hypotensor is comprised of the Chinese medicine of following weight portion proportioning:
Described promoting blood circulation to remove obstruction in the collateral class is Rhizoma Chuanxiong, and described nourishing YIN for suppressing the hyperactive YANG class is Os Draconis, and described diuresis class is Poria.
A preparation method for above-mentioned Chinese hypotensor, comprises the following steps:
(1) take by weight 12 parts of promoting blood circulation to remove obstruction in the collateral classes, 10 parts of nourishing YIN for suppressing the hyperactive YANG classes, 15 parts of diuresis classes, 12 parts of Semen Cassiaes, 8 parts of Flos Loniceraes, 5 parts of Spica Prunellaes, 5 parts of the Radixs Astragali, 8 parts of Semen Sterculiae Lychnophoraes, 8 parts of Fructus Crataegis, be ground into fine powder, cross 60 mesh sieves, add purified water to extract, the temperature of extracting is 80 ℃, the time of extracting is 45min, obtains extracting solution;
(2) in the extracting solution making in step (1), add 50% alcoholic solution to carry out filtering and concentrating, concentrated temperature is 80 ℃, and the concentrated time is 45min, to remove impurity, obtains concentrated solution;
(3) to the concentrated solution making in step (2), adopt macroporous adsorptive resins to carry out eluting, the alcoholic solution that the desorbing agent of employing is 30%, elution flow rate is 0.8BV/h, and elution time is 30min, and eluting temperature is 60 ℃, and eluting 2 times, obtains eluent;
(4) eluent making in step (3) is dried and makes Chinese medicinal powder;
(5) Chinese medicinal powder making in step (4) is processed, made tablet.
Embodiment 3
A Chinese hypotensor, described Chinese hypotensor is comprised of the Chinese medicine of following weight portion proportioning:
Described promoting blood circulation to remove obstruction in the collateral class is Rhizoma Corydalis.
Described nourishing YIN for suppressing the hyperactive YANG class is Concha Ostreae and Os Draconis, and the ratio of described Concha Ostreae and the weight portion of Os Draconis is 1.5:2.
Described diuresis class is Folium Nelumbinis.
A preparation method for above-mentioned Chinese hypotensor, comprises the following steps:
(1) take by weight 8 parts of promoting blood circulation to remove obstruction in the collateral classes, 7 parts of nourishing YIN for suppressing the hyperactive YANG classes, 10 parts of diuresis classes, 8 parts of Semen Cassiaes, 6 parts of Flos Loniceraes, 3.5 parts of Spica Prunellaes, 3 parts of the Radixs Astragali, 5.5 parts of Semen Sterculiae Lychnophoraes, 5.5 parts of Fructus Crataegis, be ground into fine powder, cross 60 mesh sieves, add purified water to extract, the temperature of extracting is 75 ℃, the time of extracting is 35min, obtains extracting solution;
(2) in the extracting solution making in step (1), add 48% alcoholic solution to carry out filtering and concentrating, concentrated temperature is 75 ℃, and the concentrated time is 35min, to remove impurity, obtains concentrated solution;
(3) to the concentrated solution making in step (2), adopt macroporous adsorptive resins to carry out eluting, the alcoholic solution that the desorbing agent of employing is 25%, elution flow rate is 0.7BV/h, and elution time is 25min, and eluting temperature is 55 ℃, and eluting 2 times, obtains eluent;
(4) eluent making in step (3) is dried and makes Chinese medicinal powder;
(5) Chinese medicinal powder making in step (4) is processed, made capsule.
Embodiment 4
A Chinese hypotensor, described Chinese hypotensor is comprised of the Chinese medicine of following weight portion proportioning:
Described promoting blood circulation to remove obstruction in the collateral class is Radix Curcumae, Rhizoma Chuanxiong, Rhizoma Corydalis, the Radix Paeoniae Alba and Radix Salviae Miltiorrhizae, and the ratio of the weight portion of described Radix Curcumae, Rhizoma Chuanxiong, Rhizoma Corydalis, the Radix Paeoniae Alba and Radix Salviae Miltiorrhizae is 3:5:3.5:4.5:6.
Described nourishing YIN for suppressing the hyperactive YANG class is Concha Ostreae and Os Draconis, and the ratio of described Concha Ostreae and the weight portion of Os Draconis is 5.5:5.
Described diuresis class is Rhizoma Alismatis, Radix Rehmanniae Preparata, Poria, Folium Nelumbinis or Exocarpium Benincasae, and the ratio of the weight portion of described Rhizoma Alismatis, Radix Rehmanniae Preparata, Poria, Folium Nelumbinis and Exocarpium Benincasae is 5:5:5.5:4.5:4.5.
A preparation method for above-mentioned Chinese hypotensor, comprises the following steps:
(1) take by weight 8 parts of promoting blood circulation to remove obstruction in the collateral classes, 7 parts of nourishing YIN for suppressing the hyperactive YANG classes, 10 parts of diuresis classes, 8 parts of Semen Cassiaes, 6 parts of Flos Loniceraes, 3.5 parts of Spica Prunellaes, 3 parts of the Radixs Astragali, 5.5 parts of Semen Sterculiae Lychnophoraes, 5.5 parts of Fructus Crataegis, be ground into fine powder, cross 60 mesh sieves, add purified water to extract, the temperature of extracting is 75 ℃, the time of extracting is 35min, obtains extracting solution;
(2) in the extracting solution making in step (1), add 48% alcoholic solution to carry out filtering and concentrating, concentrated temperature is 75 ℃, and the concentrated time is 35min, to remove impurity, obtains concentrated solution;
(3) to the concentrated solution making in step (2), adopt macroporous adsorptive resins to carry out eluting, the alcoholic solution that the desorbing agent of employing is 25%, elution flow rate is 0.7BV/h, and elution time is 25min, and eluting temperature is 55 ℃, and eluting 2 times, obtains eluent;
(4) eluent making in step (3) is dried and makes Chinese medicinal powder;
(5) Chinese medicinal powder making in step (4) is processed, made slow releasing capsule.The above embodiment is preferred embodiments of the present invention, is not to limit the scope of the present invention, and the equivalence of doing according to structure, feature and principle described in the present patent application the scope of the claims therefore all changes or modifies, and all should comprise in patent claim of the present invention.
Claims (10)
1. a Chinese hypotensor, is characterized in that, described Chinese hypotensor is comprised of the Chinese medicine of following weight portion proportioning:
2. a kind of Chinese hypotensor according to claim 1, is characterized in that, described promoting blood circulation to remove obstruction in the collateral class is selected from one or more in Radix Curcumae, Rhizoma Chuanxiong, Rhizoma Corydalis, the Radix Paeoniae Alba or Radix Salviae Miltiorrhizae.
3. a kind of Chinese hypotensor according to claim 2, is characterized in that, the ratio of the weight portion of described Radix Curcumae, Rhizoma Chuanxiong, Rhizoma Corydalis, the Radix Paeoniae Alba or Radix Salviae Miltiorrhizae is (1-3): (2-5): (1.5-3.5): (1.5-4.5): (2-6).
4. a kind of Chinese hypotensor according to claim 1, is characterized in that, described nourishing YIN for suppressing the hyperactive YANG class is selected from one or more in Concha Ostreae or Os Draconis.
5. a kind of Chinese hypotensor according to claim 1, is characterized in that, the ratio of described Concha Ostreae or the weight portion of Os Draconis is (1.5-5.5): (2-5).
6. a kind of Chinese hypotensor according to claim 1, is characterized in that, described diuresis class is selected from one or more in Rhizoma Alismatis, Radix Rehmanniae Preparata, Poria, Folium Nelumbinis or Exocarpium Benincasae.
7. a kind of Chinese hypotensor according to claim 1, is characterized in that, the ratio of the weight portion of described Rhizoma Alismatis, Radix Rehmanniae Preparata, Poria, Folium Nelumbinis or Exocarpium Benincasae is (1-5): (1-5): (3.5-5.5): (1.5-4.5): (2-4.5).
8. a preparation method for the Chinese hypotensor as described in as arbitrary in claim 1-6, is characterized in that, comprises the following steps:
(1) take by weight promoting blood circulation to remove obstruction in the collateral class 5-12 part, nourishing YIN for suppressing the hyperactive YANG class 5-10 part, diuresis class 8-15 part, Semen Cassiae 5-12 part, Flos Lonicerae 4-8 part, Spica Prunellae 2-5 part, Radix Astragali 1-5 part, Semen Sterculiae Lychnophorae 5-8 part, Fructus Crataegi 3-8 part, be ground into fine powder, cross 60 mesh sieves, add solvent to extract, obtain extracting solution;
(2) in the extracting solution making in step (1), add solvent to carry out filtering and concentrating, to remove impurity, obtain concentrated solution;
(3) to the concentrated solution making in step (2), adopt macroporous adsorptive resins to carry out eluting, eluting 2 times, obtains eluent;
(4) eluent making in step (3) is dried and makes Chinese medicinal powder;
(5) Chinese medicinal powder making in step (4) is processed, made pill, tablet capsule, slow releasing pill, slow releasing tablet, slow releasing capsule.
9. the preparation method of a kind of Chinese hypotensor according to claim 7, is characterized in that, the solvent described in step (1) is purified water, and the temperature of extraction is 65-80 ℃, and the time of extraction is 30-45min; Solvent described in step (2) is that concentration is the alcoholic solution of 45%-50%, and the temperature of concentration is 65-80 ℃, and the concentrated time is 30-45min.
10. the preparation method of a kind of Chinese hypotensor according to claim 7, it is characterized in that, the alcoholic solution that the desorbing agent adopting during eluting in step (3) is 20-30%, elution flow rate is 0.6-0.8BV/h, elution time is 20-30min, and eluting temperature is 50-60 ℃.
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