CN111759878A - Traditional Chinese medicine composition for reducing blood sugar and preparation method thereof - Google Patents
Traditional Chinese medicine composition for reducing blood sugar and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for reducing blood sugar and a preparation method thereof, wherein the traditional Chinese medicine composition comprises the following components in parts by weight: 2-50 parts of gynura divaricata, 1-30 parts of ginseng and 2-50 parts of purslane. The preparation method comprises the steps of mixing, extracting, concentrating, drying, crushing and sieving gynura divaricata, ginseng, purslane, sophora flower/sophora flower, mulberry leaf, gardenia, kudzu vine root, grape seed and corn stigma according to the formula amount to obtain the traditional Chinese medicine composition. The traditional Chinese medicine composition for reducing blood sugar can recover the function of pancreatic secretion insulin or/and eliminate insulin resistance by synergistic compounding of the gynura divaricata, the ginseng and the purslane, so that the effect of effectively reducing blood sugar is achieved.
Description
Technical Field
The invention belongs to the field of traditional Chinese medicine compositions, and particularly relates to a traditional Chinese medicine composition for reducing blood sugar and a preparation method thereof.
Background
With the rapid development of social economy, people's daily life habits and dietary structures are greatly changed, which is mainly reflected in that while the amount of exercise in modern life is gradually reduced, the proportion of unhealthy foods with high calorie, high fat and low dietary fiber in the diet is gradually increased. The transformation of bad living habits and dietary structures has led to the rapid increase of symptoms such as hyperglycemia, hyperlipidemia, hypertension, obesity, etc., wherein the increase of the incidence of diabetes mellitus, which has hyperglycemia as a main symptom, and the economic burden caused thereby are most significant.
Diabetes is a metabolic disease characterized by sustained high blood glucose levels, which is caused by a series of metabolic disorders due to either failure of islet beta cells to produce sufficient insulin or resistance of body cells to the insulin produced. Insulin is a protein hormone secreted by islet beta cells in pancreas under the stimulation of endogenous or exogenous substances, is the only hormone with the function of reducing blood sugar in human body, and can promote the synthesis of glycogen, fat and protein. Lack of insulin or resistance to insulin can lead to high blood glucose levels or hyperglycemia, which in turn leads to diabetes. Diabetes, if not treated in a timely manner, can cause a variety of complications. Acute complications include diabetic ketoacidosis, a hypertonic hyperglycemic state, or death. Therefore, prevention and treatment of hyperglycemia is extremely important.
At present, no radical treatment method exists for diabetes and hyperglycemia all over the world, and for such complicated diseases, common western medicines for treating diabetes and hyperglycemia mainly comprise oral hypoglycemic medicines and injection insulin, the oral hypoglycemic medicines comprise biguanides, sulfonylureas and dietary glucose regulators and the like, and the medicines only have certain control effect on the diabetes and the hyperglycemia, have no treatment effect, mostly have liver and kidney toxic and side effects after long-term administration, and are not suitable for long-term administration.
The traditional Chinese medicine theory considers that the pathogenesis of diabetes is mainly the deficiency of yin, weak five internal organs, improper diet, overeating, fatness and sweetness, emotional disorder and excessive desire and desire, thus causing kidney yin deficiency, dryness and heat of lung and stomach and damp-heat of liver and spleen. The pathogenesis of the disease is mainly yin deficiency and dryness heat, the yin deficiency is taken as the basis, the dryness heat is taken as the index, the disease lasts for a long time, yin damages yang, and yin and yang are both deficient; yin deficiency with dryness-heat consuming fluid and burning fluid, causing blood to be viscous, blood to be stagnant with astringency, yin affecting yang, yang deficiency with congealing cold, resulting in internal stasis of blood stasis. The traditional Chinese medicine mainly comprises the types of yin deficiency and dryness heat, qi and yin deficiency and yin and yang deficiency. According to the principle of differential treatment of traditional Chinese medicine, the method of nourishing yin and clearing heat, the method of supplementing qi and nourishing yin and the method of warming yang and nourishing yin are respectively adopted for treating diabetes, and the blood circulation promoting, the blood stasis removing and the collateral dredging are simultaneously taken into consideration in the whole process, and the traditional Chinese medicine for reducing blood sugar with the efficacies of clearing heat, tonifying, regulating qi, promoting blood circulation, the blood stasis removing and the collateral dredging is usually selected for treatment in the treatment.
CN105381304A discloses a Chinese medicinal composition for treating diabetes and hyperglycemia, which comprises the following raw material medicaments by weight: 3-7 parts of pseudo-ginseng, 1-5 parts of semen cassiae, 4-8 parts of taxus chinensis leaves, 1-5 parts of watermelon peel, 1-5 parts of corn stigma, 4-8 parts of cacumen biotae, 1-5 parts of white polygonatum odoratum, 1-5 parts of eucommia ulmoides, 1-5 parts of ledebouriella seseloides bunge, 1-5 parts of rhizoma polygonati, 1-5 parts of dogwood, 1-5 parts of medlar, 1-5 parts of rhizoma dioscoreae tenuissimae and 3-7 parts of moringa oleifera roots, and the preparation method utilizes the compatibility of the components of the traditional Chinese medicines, so that the inert insulin can be effectively activated, the blood sugar is reduced, the activity of the inert insulin is recovered, the inert insulin normally participates in sugar metabolism, the utilization and conversion capacity of a human body; can protect islet cells and inhibit insulin failure, and when insulin capable of participating in glucose metabolism is increased, the islet does not need to secrete excessive insulin as before, so that the load of pancreas is reduced, necessary adjustment is obtained, and the islet cells can be protected and the islet failure can be inhibited.
CN106266216A discloses a traditional Chinese medicine composition for relieving blood sugar rise caused by diabetes and preventing and treating diabetes, wherein the traditional Chinese medicine composition consists of iris diaphragm, balsam pear and dried orange peel, and the traditional Chinese medicine composition can effectively relieve blood sugar rise caused by diabetes and prevent and treat diabetes.
CN107661475A discloses a Chinese medicinal composition for stabilizing blood sugar and treating diabetes, which is a preparation prepared from Chinese medicinal herbs or pharmaceutically acceptable auxiliary materials such as figwort root, ginseng, ganoderma lucidum, cordyceps sinensis, ligusticum wallichii, angelica sinensis, prepared rhizome of rehmannia, angelica tail, astragalus mongholicus, safflower carthamus, peach kernel, salvia miltiorrhiza, red peony root, endothelium corneum gigeriae galli, hawthorn, rhizoma sparganii, curcuma zedoary, pseudo-ginseng, eucommia ulmoides, achyranthes bidentata, earthworm, radix clematidis and the like. The invention focuses on nourishing yin to reduce pathogenic fire, softening hardness to dissipate stagnation, softening blood vessels, nourishing yin to promote the production of body fluid to cool blood, clearing away heat and toxic material, tonifying qi and blood, invigorating yang, promoting blood circulation to remove blood stasis, strengthening body resistance and eliminating evil, and eliminating evil does not damage body resistance, not only quickly stabilizes blood sugar, but also can regulate metabolic disorder, tonify kidney to treat diabetes, and get rid of the dependence on insulin.
At present, a plurality of plants and/or Chinese medicinal monomers with the blood sugar reducing function are known, and how to screen the Chinese medicinal composition with the blood sugar reducing synergistic effect has important significance for clinical application of reducing blood sugar and treating diabetes.
Disclosure of Invention
In order to solve the technical problems, the invention provides a traditional Chinese medicine composition for reducing blood sugar and a preparation method thereof.
In order to achieve the purpose, the invention adopts the following technical scheme:
a traditional Chinese medicine composition for reducing blood sugar comprises the following components in parts by weight: 2-50 parts of gynura divaricata, 1-30 parts of ginseng and 2-50 parts of purslane.
Preferably, the traditional Chinese medicine composition comprises the following components in parts by weight: 5-48 parts of gynura divaricata, 1.5-28 parts of ginseng and 5-45 parts of purslane.
The gynura divaricata has relatively high medicinal and edible values. The gynura divaricata is eaten as vegetable, has amino acid, protein, fat, sugar, vitamins, cellulose, carbohydrate, mineral substances and trace elements which are rich in common vegetables, and is a natural green food with rich nutrition. Meanwhile, the tender stem and leaf of gynura divaricata is rich in active ingredients such as flavonoid, polysaccharide, alkaloid and the like, wherein the total flavone contained in the tender stem and leaf of gynura divaricata is 86.78mg/g and VC2.52mg/g, 0.09mg/g of carotenoid, 1.42mg/g of soluble protein, 43.30mg/g of quercetin and 6.04mg/g of chlorogenic acid. Therefore, the gynura divaricata has the biological activities of reducing high blood pressure, high blood sugar, high blood fat and high blood sugar, treating scurvy and anemia, detoxifying, preventing cancer, resisting oxidation, resisting mutation, resisting inflammation, resisting bacteria and tumors, protecting liver and gallbladder, regulating immune function and the like.
Ginseng, a rhizome of Panax of Araliaceae, is a perennial herb, and is a famous and precious medicinal material and a new resource food. Ginseng has many effects of curing diseases and preserving health, and is called 'Baicao king' in Chinese herbal medicine. In recent years, more and more students turn their eyes to the effect of ginseng in reducing blood sugar. Although ginseng can not replace insulin, the ginseng can relieve symptoms and play a quite beneficial auxiliary role. Ginseng radix has effects of resisting diabetes, qi, yin deficiency, fatigue and anoxia. Modern medicine researches find that ginseng has complex components, and the components with the blood sugar reducing effect comprise ginseng extract, ginsenoside, ginseng polysaccharide, ginseng polypeptide and the like, and the components have the effects of regulating the blood sugar concentration of normal and various diabetes animal models, normalizing the disordered metabolic process and further achieving the effect of improving the diabetes condition.
Herba Portulacae is a medicinal and edible plant, and is dry aerial whole plant of herba Portulacae (annual herbaceous plant of Portulacaceae). Its function is recorded in Ben Cao gang mu, which records "disperse blood and relieve swelling, promote intestines and smooth fetus, remove toxicity and relieve stranguria, treat postpartum sweating due to debility"; it is recorded in Ben Cao Shi Yi (materia Medica) that "Xiao Xuan Pi can relieve diabetes and treat horse malignant boil and insect". Herba Portulacae is sour and cold in nature, has effects of clearing away heat and toxic materials, invigorating qi, promoting fluid production, cooling blood, stopping bleeding, dispelling blood stasis, and relieving swelling, and can be used for treating dysentery with bloody pus, heat stranguria, leukorrhagia, carbuncle, sore, and erysipelas. Modern researches show that the purslane has obvious effects of inhibiting bacteria, resisting viruses, resisting tumors, reducing blood sugar, reducing blood fat, resisting atherosclerosis, inhibiting or exciting uterine smooth muscle, enhancing immunity and the like.
The technical effects of the invention can be realized by the above technical solutions, but in some preferred embodiments, the achieved technical effects are superior to other solutions.
For example:
in some preferred embodiments, the traditional Chinese medicine composition further comprises the following components in parts by weight: 1-30 parts of sophora flower bud/sophora flower, 1-30 parts of mulberry leaf and 1-20 parts of cape jasmine.
Preferably, the weight ratio of the mulberry leaves to the gardenia is 1: 1.
In some preferred embodiments, the traditional Chinese medicine composition further comprises the following components in parts by weight: 1-20 parts of kudzu root, 1-20 parts of grape seed, 1-20 parts of medlar and 1-30 parts of corn stigma.
Preferably, the weight ratio of the kudzu root to the grape seed to the corn silk is 1:1: 2.
In some preferred embodiments, the Chinese medicinal composition comprises the following components in parts by weight: 2-50 parts of gynura divaricata, 1-30 parts of ginseng, 2-50 parts of purslane, 1-30 parts of sophora flower bud/sophora flower, 1-30 parts of mulberry leaf, 1-20 parts of gardenia, 1-20 parts of kudzu root, 1-20 parts of grape seed, 1-20 parts of wolfberry fruit and 1-30 parts of corn stigma.
In some preferred embodiments, the Chinese medicinal composition comprises the following components in parts by weight: 20 parts of gynura divaricata, 2 parts of ginseng, 20 parts of purslane, 4 parts of sophora flower bud/sophora flower bud, 2 parts of mulberry leaf, 2 parts of cape jasmine, 2 parts of kudzu root, 2 parts of grape seed, 2 parts of wolfberry fruit and 4 parts of corn stigma.
The invention also provides a preparation method of the traditional Chinese medicine composition, and the preparation method comprises the steps of mixing, extracting, concentrating, drying, crushing and sieving the gynura divaricata, the ginseng, the purslane, the sophora flower bud/sophora flower, the mulberry leaf, the gardenia, the kudzu vine root, the grape seed and the corn stigma according to the formula amount to obtain the traditional Chinese medicine composition.
Preferably, the extraction is water extraction and alcohol extraction.
The invention also provides application of the traditional Chinese medicine composition in preparation of hypoglycemic drugs and/or health foods.
The invention also provides a medicament for reducing blood sugar, which comprises the traditional Chinese medicine composition and medically acceptable auxiliary materials.
Preferably, the medicament includes, but is not limited to, granules, tablets, pills and capsules.
Compared with the prior art:
(1) the traditional Chinese medicine composition for reducing blood sugar can enhance and restore the function of pancreatic insulin secretion or/and eliminate insulin resistance through the synergistic compounding of the gynura divaricata, the ginseng and the purslane, thereby achieving the effect of effectively reducing blood sugar.
(2) The traditional Chinese medicine composition for reducing blood sugar takes medicine-food homologous traditional Chinese medicines as main raw materials, has high safety and no toxic or side effect, can be taken for a long time, effectively avoids the risk of liver injury possibly caused by the common use of a plurality of traditional Chinese medicine components, and improves the safety of medicines and the compliance of patients.
(3) The preparation method disclosed by the invention is simple in process, low in cost and suitable for large-scale production.
Detailed Description
Other advantages and effects of the present invention will become apparent to those skilled in the art from the following detailed description, which, taken in conjunction with the annexed drawings, discloses preferred embodiments of the present invention. The invention is capable of other and different embodiments and of being practiced or of being carried out in various ways, and its several details are capable of modification in various respects, all without departing from the spirit and scope of the present invention.
Before the present embodiments are further described, it is to be understood that the scope of the invention is not limited to the particular embodiments described below; it is also to be understood that the terminology used in the examples is for the purpose of describing particular embodiments only, and is not intended to limit the scope of the present invention.
When numerical ranges are given in the examples, it is understood that both endpoints of each of the numerical ranges and any value therebetween can be selected unless the invention otherwise indicated. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs.
The raw materials adopted by the invention are all the current common commercial products without special indication. Wherein the insulin kit is purchased from Yiprises technologies, Inc. of Beijing; the blood glucose kit is purchased from Shenzhen Merrill biomedical electronics GmbH; the flos Sophorae Immaturus/flos Sophorae Immaturus is flower and bud of flos Sophorae.
Basic embodiment
A traditional Chinese medicine composition for reducing blood sugar comprises the following components in parts by weight: 2-50 parts of gynura divaricata, 1-30 parts of ginseng and 2-50 parts of purslane.
Preferably, the traditional Chinese medicine composition comprises the following components in parts by weight: 5-48 parts of gynura divaricata, 1.5-28 parts of ginseng and 5-45 parts of purslane.
In some preferred embodiments, the traditional Chinese medicine composition further comprises the following components in parts by weight: 1-30 parts of sophora flower bud/sophora flower, 1-30 parts of mulberry leaf and 1-20 parts of cape jasmine.
Preferably, the weight ratio of the mulberry leaves to the gardenia is 1: 1.
In some preferred embodiments, the traditional Chinese medicine composition further comprises the following components in parts by weight: 1-20 parts of kudzu root, 1-20 parts of grape seed, 1-20 parts of medlar and 1-30 parts of corn stigma.
Preferably, the weight ratio of the kudzu root to the grape seed to the corn silk is 1:1: 2.
In some preferred embodiments, the Chinese medicinal composition comprises the following components in parts by weight: 2-50 parts of gynura divaricata, 1-30 parts of ginseng, 2-50 parts of purslane, 1-30 parts of sophora flower bud/sophora flower, 1-30 parts of mulberry leaf, 1-20 parts of gardenia, 1-20 parts of kudzu root, 1-20 parts of grape seed, 1-20 parts of wolfberry fruit and 1-30 parts of corn stigma.
In some preferred embodiments, the Chinese medicinal composition comprises the following components in parts by weight: 20 parts of gynura divaricata, 2 parts of ginseng, 20 parts of purslane, 4 parts of sophora flower bud/sophora flower bud, 2 parts of mulberry leaf, 2 parts of cape jasmine, 2 parts of kudzu root, 2 parts of grape seed, 2 parts of wolfberry fruit and 4 parts of corn stigma.
The invention also provides a preparation method of the traditional Chinese medicine composition, and the preparation method comprises the steps of mixing, extracting, concentrating, drying, crushing and sieving the gynura divaricata, the ginseng, the purslane, the sophora japonica, the mulberry leaves, the gardenia jasminoides ellis, the kudzuvine roots, the grape seeds and the corn stigma according to the formula amount.
Preferably, the extraction is water extraction and alcohol extraction.
The invention also provides application of the traditional Chinese medicine composition in preparing hypoglycemic drugs and/or health care products.
The invention also provides a medicament for reducing blood sugar, which comprises the traditional Chinese medicine composition and medically acceptable auxiliary materials.
Preferably, the medicament includes, but is not limited to, granules, tablets, pills and capsules.
Examples 1-6A Chinese medicinal composition for lowering blood sugar and its preparation method
The raw material compositions of the hypoglycemic traditional Chinese medicine compositions in examples 1-6 are shown in table 1.
TABLE 1A Chinese medicinal composition for lowering blood sugar
| Example 1 | Example 2 | Example 3 | Example 4 | Example 5 | Example 6 | |
| Every part of gynura divaricata | 2 | 50 | 5 | 48 | 22 | 20 |
| Ginseng/portion | 1 | 30 | 1.5 | 28 | 15 | 2 |
| Purslane/portion | 2 | 50 | 5 | 45 | 25 | 20 |
Example 7-10A Chinese medicinal composition for lowering blood sugar and its preparation method
The raw material compositions of the hypoglycemic traditional Chinese medicine compositions in examples 7-10 are shown in table 2.
TABLE 2 composition of Chinese medicinal composition for lowering blood sugar (weight parts)
| Example 7 | Example 8 | Example 9 | Example 10 | |
| Every part of gynura divaricata | 20 | 20 | 20 | 20 |
| Ginseng/portion | 2 | 2 | 2 | 2 |
| Purslane/portion | 20 | 20 | 20 | 20 |
| Flos Sophorae Immaturus/part | 1 | 30 | 15 | 4 |
| Mulberry leaf/portion | 30 | 1 | 15 | 2 |
| Gardenia jasminoides Ellis/portion | 1 | 20 | 10 | 2 |
Examples 11 to 14A Chinese medicinal composition for lowering blood sugar and its preparation method
The raw material compositions of the hypoglycemic traditional Chinese medicine compositions in examples 11 to 14 are shown in table 3.
TABLE 3 composition of Chinese medicinal composition for lowering blood sugar (weight parts)
The method for preparing the hypoglycemic traditional Chinese medicine composition described in embodiments 1 to 14 comprises the steps of drying, mixing, extracting, concentrating, drying, crushing and sieving the gynura divaricata, the ginseng, the purslane, the sophora japonica, the mulberry leaf, the gardenia jasminoides ellis, the kudzuvine root, the grape seed and the corn silk according to the formula amount to obtain the hypoglycemic traditional Chinese medicine composition.
Comparative example 1
This comparative example is different from example 6 in that the ginseng is used in an amount of 5 parts by weight.
Comparative example 2
This comparative example differs from example 6 in that purslane is replaced with lily.
Comparative example 3
This comparative example differs from example 6 in that polygonatum is used instead of gynura divaricata.
Comparative example 4
This comparative example differs from example 10 in that no mulberry leaves are contained.
Comparative example 5
This comparative example differs from example 10 in that cassia seed is substituted for gardenia.
Comparative example 6
This comparative example differs from example 14 in that it does not contain pueraria lobata.
Comparative example 7
This comparative example differs from example 14 in that coix seed was used instead of pueraria root.
Comparative example 8
This comparative example differs from example 14 in that the corn silk was replaced with dandelion.
First, acute toxicity test
1. Laboratory animal
ICR mice (purchased from Shanghai Spiker laboratory animals Co., Ltd.) weighed 18-22g, male.
2. Grouping and administration method
The ICR mice are randomly divided into 23 groups according to body weight, each group comprises 8 mice, and the traditional Chinese medicine compositions prepared in the examples 1-14 and the comparative examples 1-8 are prepared into suspensions with the concentration of 0.2g/mL respectively; the administration volume is 0.4mL/10g, and the administration dose of the mouse is determined to be 8.0 g/kg; the control group was administered with an equal volume of deionized water, all administered by gavage once a day.
3. Results of the experiment
After the gastric lavage, the mouse is quieter and can move normally. Other conditions such as diet, activity, hair color, feces, etc. are found to be abnormal. After 14 days, the weight of each animal was increased (see table 4), and no death was observed.
Table 4 effect of gavage of the Chinese medicinal composition on mouse body weight (g, n ═ 8, X ± s)
| 0d | 7d | 14d | |
| Example 1 | 19.980.45 | 26.69±1.75 | 31.10±1.57 |
| Example 2 | 19.87±0.43 | 26.51±1.73 | 30.96±1.59 |
| Example 3 | 20.01±0.47 | 26.67±1.68 | 30.92±1.56 |
| Example 4 | 19.93±0.42 | 26.59±1.70 | 30.86±1.54 |
| Example 5 | 19.95±0.43 | 26.53±1.66 | 30.78±1.52 |
| Example 6 | 20.14±0.52 | 25.99±1.62 | 29.87±1.50 |
| Example 7 | 20.12±0.50 | 25.64±1.60 | 29.01±1.48 |
| Example 8 | 19.90±0.48 | 25.24±1.64 | 28.61±1.42 |
| Example 9 | 20.08±0.49 | 25.49±1.67 | 28.89±1.46 |
| Example 10 | 20.00±0.45 | 25.18±1.65 | 28.57±1.51 |
| Example 11 | 20.10±0.47 | 24.48±1.56 | 27.43±1.45 |
| Example 12 | 19.94±0.43 | 24.34±1.57 | 27.27±1.43 |
| Example 13 | 20.13±0.52 | 24.25±1.52 | 26.99±1.34 |
| Control group | 20.18±0.53 | 27.00±1.68 | 31.59±1.58 |
As can be seen from the above table, the maximum tolerated dose MTD of the traditional Chinese medicine composition provided by the invention for mice after gastric lavage is greater than 8.0g/kg, and no obvious abnormality of the mice is seen. Therefore, the traditional Chinese medicine composition has no toxic or side effect and high safety, can be taken for a long time, effectively avoids the risk of liver injury caused by the common use of various traditional Chinese medicine components, and improves the safety of the medicine and the compliance of patients.
Second, hypoglycemic test
1. Establishment of diabetes animal model
ICR mice are intraperitoneally injected with 200mg/kg · bw 4% alloxan solution, before injection, fasting is carried out for 12h without water prohibition, after 72h, blood collection is carried out on orbital venous plexus to measure fasting blood glucose, and the mice with blood glucose value larger than 11.1mmol/L are experimental diabetes animal models.
2. Grouping and administration of drugs
The successfully modeled diabetes animal models are randomly divided into 23 groups of 8 animals, wherein 22 groups are experimental groups, the traditional Chinese medicine composition for reducing blood sugar prepared in examples 1-14 and comparative examples 1-8 is respectively gavaged every day, the gavage dose is 200mg/kg, 1 group of model control groups are gavaged every day with physiological saline with the same volume. Meanwhile, 1 group of normal control groups (8 normal mice) is provided, and the normal saline with the same volume as the stomach is infused every day; the stomach 28d is perfused continuously.
Fasting Blood Glucose (FBG) values were measured once per week for each group of mice; fasting for 12h before the last administration, blood sampling of orbital vein after 2h administration, serum centrifugation, and serum insulin level determination by kit method.
TABLE 5 Effect of the Chinese medicinal composition of the present invention on fasting blood glucose levels of mice of each group (X + -s, mmol/L)
Note: the # P is less than 0.01, and has very significant difference compared with a normal control group; p < 0.5, with significant difference compared to model control; p < 0.01, with a very significant difference compared to the model control group.
As can be seen from Table 5, the fasting blood glucose of the mice of the normal control group and the model control group of the invention is very significantly different (P is less than 0.01), which indicates that the model of the diabetes animal model of the invention is successfully modeled.
The fasting blood glucose monitored by 21d and 28d of the mice filled with the traditional Chinese medicine composition prepared in the groups 1 to 6 of the invention is significantly different (P is less than 0.5) compared with the control group of the model, which shows that the traditional Chinese medicine composition prepared by the invention has the effect of reducing blood glucose.
Meanwhile, it was found that the fasting blood glucose monitored at 14d and 21d of the mice filled with the Chinese medicinal composition prepared in the gavage example 6 is significantly different (P < 0.5) compared with the control group; the fasting blood glucose monitored at 28d was significantly different (P < 0.01) from the model control group. The prepared traditional Chinese medicine composition has a good blood sugar reduction effect when the weight ratio of the gynura divaricata, the ginseng and the purslane is 10:1: 10.
As can be seen from the above Table 5, the mice fed with the Chinese medicinal composition prepared in the gavage examples 7-9 showed significant differences in fasting blood glucose (P < 0.5) in 14d and 21d, compared with the model control group; the fasting blood glucose monitored at 28d is very significantly different (P is less than 0.01) compared with the model control group; in mice fed with the traditional Chinese medicine composition prepared in the gavage example 10, fasting blood glucose monitored at 21d and 28d is very significantly different (P is less than 0.01) compared with a model control group; the weight ratio of the mulberry leaves to the gardenia is 1:1, so that the prepared traditional Chinese medicine composition has a good blood sugar reduction effect.
As can be seen from the above Table 5, the mice fed with the Chinese medicinal composition prepared in the gavage examples 11-13 showed significant differences (P < 0.5) in fasting blood glucose monitored at 7d and 14d, compared with the control group; the fasting blood sugar monitored by 21d and 28d is very different from that of the model control group (P is less than 0.01); the 7d fasting blood glucose of the mice with the Chinese medicinal composition prepared in the gavage example 14 is significantly different (P < 0.5) compared with the control group; the fasting blood glucose monitored at 14d, 21d and 28d is very significantly different (P < 0.01) compared with the model control group; the prepared traditional Chinese medicine composition has a good blood sugar reducing effect when the weight of the kudzu root, the grape seed and the corn stigma is 1:1: 2.
TABLE 6 Effect of the Chinese medicinal composition of the present invention on serum insulin levels (X + -s, mU/L) of mice of each group
| Normal control group | 15.38±1.86 |
| Model control group | 7.38±1.21## |
| Example 1 | 11.53±1.34* |
| Example 2 | 11.57±1.28* |
| Example 3 | 11.61±1.24* |
| Example 4 | 11.65±1.30* |
| Example 5 | 11.70±1.31* |
| Example 6 | 12.39±1.28* |
| Example 7 | 12.53±1.32* |
| Example 8 | 12.57±1.37* |
| Example 9 | 12.62±1.39* |
| Example 10 | 12.77±1.41* |
| Example 11 | 12.91±1.38* |
| Example 12 | 12.95±1.27* |
| Example 13 | 13.01±1.25* |
| Example 14 | 13.95±1.29** |
| Comparative example 1 | 11.62±1.24* |
| Comparative example 2 | 10.20±1.21 |
| Comparative example 3 | 10.48±1.18 |
| Comparative example 4 | 12.42±1.37* |
| Comparative example 5 | 12.45±1.41* |
| Comparative example 6 | 12.79±1.34* |
| Comparative example 7 | 12.83±1.38* |
| Comparative example 8 | 12.80±1.40* |
Note: the # P is less than 0.01, and has very significant difference compared with a normal control group; p < 0.5, with significant difference compared to model control; p < 0.01, with a very significant difference compared to the model control group.
As can be seen from table 6, the serum insulin level of the mouse of the model control group is significantly lower than that of the normal control group and shows a significant difference (P < 0.01), and the insulin level of the mouse of the gavage traditional Chinese medicine composition prepared in the embodiments 1 to 14 of the present invention is significantly higher (P < 0.5) than that of the model control group, which indicates that the traditional Chinese medicine composition prepared in the present invention may have the abilities of repairing islet β cells and increasing insulin secretion of the islet β cells, thereby increasing the serum insulin level of the diabetic mouse and reducing the blood sugar of the diabetic mouse.
In conclusion, the traditional Chinese medicine composition for reducing blood sugar can recover the function of pancreatic insulin secretion or/and eliminate insulin resistance through the synergistic compounding of the gynura divaricata, the ginseng and the purslane, so that the effect of effectively reducing blood sugar is achieved.
The traditional Chinese medicine composition for reducing blood sugar takes medicine-food homologous traditional Chinese medicines as main raw materials, has high safety and no toxic or side effect, can be taken for a long time, effectively avoids the risk of liver injury possibly caused by the common use of a plurality of traditional Chinese medicine components, and improves the safety of medicines and the compliance of patients.
In addition, the preparation method provided by the invention is simple in process, low in cost and suitable for large-scale production.
It should be emphasized that the embodiments described herein are illustrative rather than restrictive, and thus the present invention is not limited to the embodiments described in the detailed description, but also includes other embodiments that can be derived from the technical solutions of the present invention by those skilled in the art.
Claims (10)
1. The traditional Chinese medicine composition for reducing blood sugar is characterized by comprising the following components in parts by weight: 2-50 parts of gynura divaricata, 1-30 parts of ginseng and 2-50 parts of purslane.
2. The traditional Chinese medicine composition according to claim 1, which is characterized by comprising the following components in parts by weight: 5-48 parts of gynura divaricata, 1.5-28 parts of ginseng and 5-45 parts of purslane.
3. The traditional Chinese medicine composition according to claim 1, further comprising, in parts by weight: 1-30 parts of sophora flower bud/sophora flower, 1-30 parts of mulberry leaf and 1-20 parts of cape jasmine.
4. The Chinese medicinal composition according to claim 3, wherein the weight ratio of the mulberry leaves to the gardenia is 1: 1.
5. The traditional Chinese medicine composition according to claim 3, further comprising, in parts by weight: 1-20 parts of kudzu root, 1-20 parts of grape seed, 1-20 parts of medlar and 1-30 parts of corn stigma.
6. The traditional Chinese medicine composition of claim 5, wherein the weight ratio of the kudzu root to the grape seed to the corn silk is 1:1: 2.
7. The traditional Chinese medicine composition according to claim 5, which is characterized by comprising the following components in parts by weight: 2-50 parts of gynura divaricata, 1-30 parts of ginseng, 2-50 parts of purslane, 1-30 parts of sophora flower bud/sophora flower, 1-30 parts of mulberry leaf, 1-20 parts of gardenia, 1-20 parts of kudzu root, 1-20 parts of grape seed, 1-20 parts of wolfberry fruit and 1-30 parts of corn stigma.
8. The traditional Chinese medicine composition according to claim 7, which comprises the following components in parts by weight: 20 parts of gynura divaricata, 2 parts of ginseng, 20 parts of purslane, 4 parts of sophora flower bud/sophora flower bud, 2 parts of mulberry leaf, 2 parts of cape jasmine, 2 parts of kudzu root, 2 parts of grape seed, 2 parts of wolfberry fruit and 4 parts of corn stigma.
9. The method for preparing a Chinese medicinal composition according to any one of claims 1 to 8, wherein the method comprises mixing, extracting, concentrating, drying, crushing and sieving the gynura divaricata, ginseng, purslane, sophora flower bud/flower bud, mulberry leaf, gardenia, kudzu vine root, grape seed and corn silk in formula amounts to obtain the Chinese medicinal composition.
10. Use of the Chinese medicinal composition according to any one of claims 1 to 8 in the preparation of hypoglycemic drugs and/or health foods.
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