CN110882362A - Traditional Chinese medicine food therapy product for conditioning diabetes and preparation method thereof - Google Patents

Traditional Chinese medicine food therapy product for conditioning diabetes and preparation method thereof Download PDF

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CN110882362A
CN110882362A CN201911341792.8A CN201911341792A CN110882362A CN 110882362 A CN110882362 A CN 110882362A CN 201911341792 A CN201911341792 A CN 201911341792A CN 110882362 A CN110882362 A CN 110882362A
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parts
raw materials
chinese medicine
traditional chinese
therapy product
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勾艳霞
官美芳
刘桂元
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Baoding Shengxia Trade Co Ltd
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Baoding Shengxia Trade Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8969—Polygonatum (Solomon's seal)
    • A—HUMAN NECESSITIES
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    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A—HUMAN NECESSITIES
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    • A61K35/57—Birds; Materials from birds, e.g. eggs, feathers, egg white, egg yolk or endothelium corneum gigeriae galli
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/287—Chrysanthemum, e.g. daisy
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/482—Cassia, e.g. golden shower tree
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    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/894—Dioscoreaceae (Yam family)
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    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A61K36/8994—Coix (Job's tears)
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Abstract

The invention relates to a traditional Chinese medicine food therapy product for conditioning diabetes and a preparation method thereof, wherein the traditional Chinese medicine food therapy product comprises the following raw materials, by weight, 650 parts of rhizoma polygonati, 600 parts of radix puerariae, 550 parts of poria cocos, 550 parts of medlar, 500 parts of hawthorn, 480 parts of radix polygonati officinalis, 450 parts of mulberry, 550 parts of Chinese yam, 350 parts of chrysanthemum, 300 parts of folium mori, 380 parts of fructus angelicae kochiae, 400 parts of kelp, 450 parts of oyster, 500 parts of semen coicis, 400 parts of peach kernel, 350 parts of endothelium corneum gigeriae galli, 550 parts of balsam pear and 500 parts of semen cassiae.

Description

Traditional Chinese medicine food therapy product for conditioning diabetes and preparation method thereof
Technical Field
The invention belongs to the field of medicinal and edible traditional Chinese medicine food, and particularly relates to a traditional Chinese medicine food therapy product for conditioning diabetes and a preparation method thereof.
Background
Diabetes is a common disease and a chronic disease caused by the interaction of multiple factors such as heredity, diet and environment, and the like, the clinical application takes hyperglycemia as a main mark, common symptoms comprise polydipsia, diuresis, polyphagia, emaciation and the like, and if effective conditioning treatment cannot be obtained, the damage of multiple systems of a body can be caused; causing the absolute or relative hyposecretion of insulin and the reduction of the sensitivity of target tissue cells to insulin, and causing a series of metabolic disturbance syndromes of protein, fat, water and electrolyte, wherein hyperglycemia is taken as a main marker. The clinical typical cases can show symptoms of polyuria, polydipsia, polyphagia, emaciation and the like, namely three more or one less symptoms. Serious patients can cause infection, heart disease, cerebrovascular disease, renal failure, binocular blindness, lower limb gangrene and the like to become the main cause of death and disability. Hypertonic syndrome is a serious acute complication of diseases, can be manifested as polyuria, polydipsia, lassitude, hypodynamia, slow response and the like in the initial stage, and can be developed rapidly along with the increase of water loss of the body, so that symptoms such as sleepiness, dystropism, epileptic tetany, hemiplegia and the like similar to cerebral apoplexy appear, and even coma occurs.
At present, there is no cure for diabetes worldwide. For such complicated and intractable diseases, it is obviously difficult to take effect only by the compatibility of one medicine or simple Chinese medicine prescription.
Disclosure of Invention
The invention aims to overcome the defects of the prior art, and provides a traditional Chinese medicine food therapy product for conditioning diabetes and a preparation method thereof.
In order to achieve the purpose, the technical scheme adopted by the invention is as follows:
the first technical scheme is as follows:
a traditional Chinese medicine diet therapy product for conditioning diabetes comprises the following raw materials in parts by weight:
600-700 parts of rhizoma polygonati, 550-650 parts of radix puerariae, 500-600 parts of poria cocos and 500-600 parts of medlar; 450-550 parts of hawthorn, 430-530 parts of polygonatum, 400-500 parts of mulberry and 500-600 parts of Chinese yam; 300-400 parts of chrysanthemum, 250-350 parts of mulberry leaves, 330-530 parts of common anemarrhena fruit and 350-450 parts of kelp; 400-500 parts of oyster, 450-550 parts of coix seed, 350-450 parts of peach seed, 300-400 parts of chicken's gizzard-membrane, 500-600 parts of bitter gourd and 450-550 parts of cassia seed.
Further, a traditional Chinese medicine diet therapy product for conditioning diabetes comprises the following raw materials in parts by weight:
650 parts of rhizoma polygonati, 600 parts of radix puerariae, 550 parts of poria cocos and 550 parts of Chinese wolfberry; 500 parts of hawthorn, 480 parts of polygonatum, 450 parts of mulberry and 550 parts of Chinese yam; 350 parts of chrysanthemum, 300 parts of mulberry leaves, 380 parts of common clubmoss herb and 400 parts of kelp; 450 parts of oyster, 500 parts of coix seed, 400 parts of peach seed, 350 parts of chicken's gizzard-membrane, 550 parts of balsam pear and 500 parts of cassia seed.
The second technical scheme is as follows:
a preparation method of a traditional Chinese medicine food therapy product for conditioning diabetes comprises the following steps:
step 1, pretreatment:
sorting the raw materials, removing mildewed and deteriorated raw materials, cleaning, drying and crushing for later use;
step 2, extraction:
weighing the raw materials according to the weight parts, adding the raw materials into an extraction tank, adding solvent purified water into the raw materials according to the volume ratio of the raw materials to the liquid of 1:5, soaking the raw materials for 40 minutes at normal temperature, heating the raw materials to be boiled, decocting the raw materials in boiling water for three times, decocting the raw materials for 30 minutes for the first time, and stabilizing the raw materials for 30 minutes; decocting for 50 minutes for the second time, and stabilizing for 30 minutes; decocting for 40 minutes for the third time, filtering, and mixing the three decoctions to obtain an extract;
and step 3, concentrating:
concentrating the extractive solution by a concentrating unit until the specific gravity is 1.10-1.20 to obtain concentrated solution;
and 4, drying:
spray drying the concentrated solution to obtain Chinese medicinal fine powder.
Further, the method also comprises the following steps of 5, checking: sterilizing the Chinese medicinal fine powder by cobalt 60-r ray irradiation, sealing, and storing.
Further, in the step 2, the vapor-liquid mixture evaporated in the decoction process is defoamed by a foam catcher, cooled by a condenser and a cooler, and finally reflows to the extraction tank through a vapor-liquid separator.
The invention is prepared by taking 18 traditional Chinese medicines of rhizoma polygonati, balsam pear, kudzu root, fragrant solomonseal rhizome, hawthorn, tuckahoe, oyster, wild chrysanthemum, mulberry leaf, coix seed, common clubmoss fruit, mulberry, cassia seed, medlar, peach seed, chicken's gizzard-membrane, kelp and Chinese yam as raw materials.
Wherein the content of the first and second substances,
rhizoma polygonati: sweet and neutral. It enters spleen, lung and kidney meridians. Has effects in enhancing immunity, nourishing kidney, moistening lung, invigorating spleen, invigorating qi, resisting aging, resisting anoxia, relieving fatigue, improving metabolism, lowering blood sugar, and tonifying heart. It can be used for treating weakness of spleen and stomach, asthenia, xerostomia, thirst, internal heat, cough due to lung deficiency, chronic cough, dizziness due to kidney deficiency, soreness of waist and knees, and premature gray hair. The efficacy of tonifying qi and nourishing yin is that the efficacy is the same as that of prepared rhizome of rehmannia without greasy, and the efficacy is similar to that of ginseng and astragalus without heat, so that the food in the book of food debates and records is mainly used for treating all kinds of deficiency and damage, is not restricted by deficiency of yin and yang, qi and blood, and is not inappropriate, is an ideal food therapy product for patients with swollen diabetes, and can be eaten for a long time.
Bitter gourd: bitter, non-toxic, cold in nature, entering heart, liver, spleen and lung meridians. Has effects in clearing away summer heat, improving eyesight, removing toxic materials, lowering blood pressure, lowering blood sugar, promoting urination, cooling blood, relieving fatigue, clearing away heart-fire, invigorating qi, and supporting yang. The Yunnan herbal medicine: treating erysipelas, furuncle, malignant boil and toxin, purging excess fire of six channels, clearing summer-heat, tonifying qi and quenching thirst. "the student's edition: to remove pathogenic heat, relieve fatigue, clear heart fire and improve vision. "the materia Medica: to remove heat and relieve restlessness. "modern research has confirmed that: after the balsam pear juice is infused into normal rabbits suffering from alloxan diabetes, the blood sugar can be obviously reduced. The rat with hyperglycemia caused by subcutaneous injection of anterior pituitary extract also has the function of reducing blood sugar by irrigating water extract of balsam pear juice. Oral administration of charantin to rabbits can lower blood sugar, and has a stronger action similar to tolbutamide.
Kudzu root: radix Puerariae is sweet and pungent, neutral in nature, and contains flavonoid glycoside and starch. Has effects in promoting salivation, quenching thirst, invigorating yang, and relieving exterior syndrome. According to the descriptions of the rights and the wisdom of Ben Cao gang mu, Chinese medicine dictionary, functional food, etc., the kudzuvine root and the products thereof have the good effects of clearing away heat, expelling toxin, reducing blood fat, blood pressure, cholesterol and blood sugar, losing weight, relaxing bowels, preventing senile dementia, arteriosclerosis, cerebral thrombosis, etc. The kudzu root has extremely high medicinal value and is known as the Asian ginseng, and the kudzu root powder is known as the longevity powder and is known as royalty food in Japan. The kudzu powder can regulate the function of a human body, enhance the physique, improve the disease resistance of the organism, resist senility and prolong life, and keep youth and vitality for a long time when being eaten.
Fragrant solomonseal rhizome: sweet in taste and neutral in nature; entering lung and stomach meridians; moistening and descending, and has effects of moistening lung, nourishing yin, invigorating stomach, and promoting fluid production. Mainly treats dry heat cough, consumptive disease chronic cough; thirst due to yin impairment due to febrile diseases, thirst due to internal heat; dizziness, spasm and pain of tendons and vessels due to yin deficiency with exogenous pathogenic factors. For those with thirst due to internal heat, it is combined with shan Yao to nourish yin, clear heat, promote fluid production and quench thirst.
Hawthorn fruit: slightly warm in nature, sour and sweet. Has effects in promoting digestion, invigorating stomach, promoting qi circulation, and dispelling blood stasis. It can be used for treating dyspepsia, flatulence, dysentery, abdominal pain, blood stasis, amenorrhea, puerperal stagnation, pain in heart and abdomen, hernia pain, and hyperlipidemia.
Clinical research proves that the hawthorn can obviously reduce serum cholesterol and triglyceride and effectively prevent and treat atherosclerosis; the hawthorn can also play roles in strengthening heart and preventing angina pectoris by enhancing myocardial contractility, expanding coronary artery blood vessels, increasing coronary blood flow, reducing myocardial oxygen consumption and the like. In addition, the hawthorn also has good hypoglycemic effect. Therefore, it is especially suitable for patients with hyperlipidemia, hypertension and diabetes.
Tuckahoe, poria cocos: sweet, bland and mild. It enters heart, spleen and kidney meridians. Induce diuresis and drain dampness, invigorate spleen and soothe the nerves. Mainly treats edema, dysuria, weakness of spleen and stomach, anorexia, lassitude and hypodynamia, spleen deficiency and damp diarrhea, palpitation and insomnia. Has tranquilizing and blood sugar lowering effects.
Oyster shell: sweet, salty and neutral in nature. Has effects in nourishing yin, tonifying blood, nourishing heart, and tranquilizing mind. Can be used for treating consumptive disease, yin deficiency and hemophthisis; insomnia and palpitation. The oyster contains 18 kinds of amino acids, glycogen, vitamin B, taurine, calcium, phosphorus, iron, zinc and other nutrients, and may be eaten frequently to raise immunity. The taurine contained in Concha Ostreae has effects of reducing blood lipid and lowering blood pressure.
Wild chrysanthemum flower: dispel wind and clear heat, pacify liver and improve vision. Can be used for treating headache, vertigo, conjunctival congestion, swelling and pain, dysphoria with smothery sensation in chest, sore, and toxic swelling. Is one of the traditional common Chinese medicinal materials, is beneficial to human being after long-term administration, resists senility and prolongs life. Furthermore, modern medical research suggests that: 1) the wild chrysanthemum has the effects of resisting bacteria and diminishing inflammation: has inhibitory effect on gram-positive bacteria and human type tubercle bacillus in vitro; also has some inhibiting effect on some common skin pathogenic fungi. The extract can be injected into mouse abdominal cavity, and has effects of inhibiting capillary permeability and resisting inflammation. It also has analgesic and wound healing effects, and can be used for treating gastralgia and gastric ulcer, and promoting blood circulation. It can promote urination and reduce fever when being drunk for severe cold. 2) The wild chrysanthemum has the effect of protecting heart and brain: the chrysanthemum can dilate coronary artery, promote blood circulation, increase blood flow and reduce blood pressure, and has good curative effects on coronary heart disease, hypertension, arteriosclerosis, diabetes and serum cholesterol.
Mulberry leaf: disperse wind-heat, clear lung-heat and moisten dryness, clear liver and improve vision. Can be used for treating wind-heat type common cold, lung heat type cough, dizziness, headache, conjunctival congestion, and dim eyesight. In ancient times, the traditional Chinese medicine uses mulberry leaves as a traditional Chinese medicine for treating diabetes, and the traditional Chinese medicine is recorded in compendium of materia medica: folium Mori decocted as tea can be used for treating diabetes; moxibustion, cooked and decocted for drinking, which is used as tea to quench thirst. Modern doctors often combine mulberry leaves with Chinese herbal medicine compound for clinical application, and the effect is obtained more often. Modern pharmacological research proves that mulberry leaves have the function of inhibiting the rise of blood sugar and can prevent and treat diabetes. In recent years, researchers in various countries carry out systematic research on the composition, function and action mechanism of mulberry leaves, and as a result, the mulberry leaves are found to contain abundant amino acids, cellulose, vitamins, minerals and various physiologically active substances and have the effect of reducing blood sugar.
Coix seed: to invigorate the spleen, drain dampness, check diarrhea and expel pus. Can be used for treating diarrhea due to spleen deficiency, muscle soreness, and arthralgia. Removing dampness and invigorating spleen; relaxing muscles and tendons and removing arthralgia; clear heat and expel pus. Effect on cardiovascular system: inhibiting respiratory center, and dilating peripheral blood vessels, especially pulmonary blood vessels. Has immunity enhancing and antiinflammatory effects, and can promote cellular immunity and humoral immunity. Modern medicine proves that the traditional Chinese medicine can play a role in expanding blood vessels and reducing blood sugar, and particularly has special effects on hypertension and hyperglycemia.
And (3) adding natural fruits: a tropical fruit has cold property, and has antipyretic and astringent effects. Improving body function, enhancing immunity, strengthening body resistance, activating cell, preventing aging, and delaying aging, and is beneficial to diabetes patients. The principle of reducing blood sugar to Tianguo is that it can regulate metabolism function of body, make self insulin be "revived" and fully act, so that the blood sugar can be reuptake and utilized by organism tissue cell, and the blood sugar can be reduced, so that it can attain the goal of long-term stable and comprehensive control of blood sugar, and can make human body can enjoy self-secreted insulin for a long time to decompose blood sugar. The fermented milk not only has the function of directly reducing blood sugar, but also can replace hypoglycemic drugs, and the hypoglycemic drugs can be stopped from being taken under the condition that the blood sugar is kept normal and stable. The liver protection effect of the natural plant can also reduce or prevent the damage of some oral hypoglycemic drugs to the liver.
Mulberry: ben Cao Jing Shu (the book of materia Medica Prime and Dredging): mulberry fruit, fructus Mori, sweet in flavor and cold in property, is a medicine for cooling blood, tonifying blood and yin, and can quench thirst due to internal heat, insufficient body fluid and fluid production. Five zang organs all belong to yin, benefiting yin and benefiting five zang organs. Insufficient yin can lead to obstruction of blood and qi in the joints, engorgement of body fluid, and exuberant yin qi can lead to no hunger and blood-qi circulation . When heat is returned to yin, the liver-heart will not have fire, so the spirit is calm and self-refreshing, the spirit is clear and clever, and the yin is white and not old. Sweet and cold in property and removing heat, so it can relieve middle-jiao toxicity. Cold in nature can induce diuresis downward, so it can induce diuresis and qi to alleviate edema. "
Cassia seed: mild in nature and salty in taste. Has the functions of clearing away heat, improving eyesight, moistening intestine, relaxing bowels, etc. It can be used for treating conjunctival congestion, photophobia, lacrimation, headache, vertigo, dim eyesight, and constipation. The book of materia Medica: the cassia seed is used for improving eyesight, nourishing liver and kidney, and suppressing diving and nourishing yin, which is the treatment for banking up root; compared with the standard disease legislation of warm, pungent and cool natured herbs for dispelling wind and cold and lowering heat, the medicine is most beneficial and has no harm. Modern pharmacological studies have demonstrated that: (1) the cassia seed has antibacterial effect, the alcohol extract of the cassia seed has inhibition effect on staphylococcus, diphtheria bacillus, typhoid bacillus, paratyphoid bacillus and colon bacillus, and the water extract is ineffective; (2) the cassia seed has the function of reducing blood fat: feeding semen Cassiae decoction or powder to rat for 8 weeks, and reducing cholesterol and triglyceride in blood plasma and reducing triglyceride in liver of experimental hyperlipemia rat; (3) the function of cassia seed on the immune function: the cassia seed water decoction can obviously increase the phagocytic percentage and the phagocytic index of mouse abdominal cavity macrophages and simultaneously improve the lysozyme level; (4) the cassia seed has good weight-losing effect after laxation and defecation.
Wolfberry fruit: has effects in resisting tumor, improving eyesight, tranquilizing mind, expelling pathogenic wind, relieving deficiency, strengthening muscle and bone, and prolonging life. Can be used for treating deficiency of liver and kidney, deficiency of qi and blood, blood deficiency, sallow complexion, soreness of waist and knees, dizziness, tinnitus, cough due to asthenia, diabetes, sexual impotence, and spermatorrhea. Especially has unique effect on enhancing sexual function. Modern pharmacological studies have demonstrated that: (1) it has the function of improving the immunologic function: the non-specific immunity is enhanced, and the phagocytic function of macrophages is improved and the serum lysozyme is enhanced by drenching the lycium barbarum water extract lycium barbarum polysaccharide to mice; (2) it has antiaging effect, and can inhibit free radical generation in liver and improve blood superoxide dismutase (SOD) activity by intragastric administration of fructus Lycii extract to mice. Human body tests also show that the Chinese wolfberry can obviously inhibit the generation of serum free radicals, increase the activity of erythrocyte SOD and prompt the Chinese wolfberry to have the function of delaying senility. (3) The betaine in the medlar can obviously increase the phospholipid in the serum and the liver of a rat, and has obvious protective effect on the reduction of the phospholipid and the increase of cholesterol of the rat caused by carbon tetrachloride for a long time. (4) The medlar extract can obviously and durably reduce the blood sugar of rats and increase the sugar tolerance. In addition, fructus Lycii has effects of resisting tumor and promoting hemopoiesis.
Peach kernel: mild in nature and bitter in taste. Has effects of removing blood stasis, moistening dryness and smoothing intestine. Can be used for treating blood accumulation due to febrile disease, abdominal mass, traumatic injury, arthralgia due to wind-evil, constipation due to intestinal dryness, amenorrhea, and dysmenorrhea. Compendium of materia Medica: tao ren has the actions of relaxing meridians, activating blood and promoting blood circulation, removing blood stasis and promoting tissue regeneration, and also has the actions of resolving masses and removing stagnation. Modern medical research proves that: (1) has the functions of removing blood stasis: can relax blood vessel, increase arterial blood flow and reduce vascular resistance, and has direct blood vessel dilating effect. The peach kernel also has the effects of inhibiting blood coagulation and hemolysis and improving the circulatory system, and has obvious effect. (2) Anti-inflammatory and anti-allergic effects: the peach kernel has the function of absorbing the inflammation, can be used for treating alone or combined with other medicines, can improve the inflammation, and has obvious treatment effect. (3) Kunren glycosides in semen Persicae have antitussive effect.
Endothelium corneum gigeriae galli: remove food stagnation, strengthen spleen and stomach. It is indicated for food retention, distention, vomiting, regurgitation, diabetes and enuresis. Modern pharmacological research considers that the endothelium corneum gigeriae galli mainly contains gastric hormone, keratin, amino acid and other components; has the functions of increasing the secretion of gastric juice, improving the digestion capacity of the stomach and the intestine, accelerating the emptying rate of the stomach and the like, and is a common good medicine for promoting digestion and relieving stasis. Endothelium corneum Gigeriae Galli can be used for preventing and treating diabetes by invigorating spleen and stomach and promoting digestion. Remove blood stasis, digest and remove food retention, and remove hyperglycemia naturally. The property of Ji Nei jin is especially suitable for deficiency of qi because it can resolve blood stasis without damaging qi system.
Kelp: salty and cold in nature, entering liver and kidney meridians, they can soften hardness, dissipate nodulation, induce diuresis and resolve dampness. The kelp is rich in nutrient components, and each 100 g of kelp contains 8 g of protein, 10.09 mg of vitamin B, 0.1 g of fat, 0.57 mg of carotene, 20.36 mg of vitamin B, 1.6 mg of nicotinic acid, 1177 mg of calcium, 150 mg of iron, 216 mg of phosphorus, 24 mg of iodine and 4 g of dietary fiber, and in addition, mannitol, potassium, zinc, cobalt, fluorine elements and the like. Contains almost no fructose and sucrose, so that the diabetic can eat the food at ease. The kelp which is eaten by sugar has great benefit for treating diseases, and the organic iodine contained in the kelp has the hormone-like effect, can improve the activity of bioactive substances in a human body, promote the secretion of insulin and adrenocortical hormone, and promote the metabolism and the effect of glucose and fatty acid in liver and muscle tissues, thereby playing the roles of reducing blood sugar and blood fat.
Chinese yam: it is used for treating diarrhea due to spleen deficiency, anorexia, edema, cough due to lung deficiency, diabetes, carbuncle, swelling, and scrofula. The herbal Zhenzhen: although warm but even, Ge Gen qi is used to nourish spleen and lung yin, it can moisten skin and hair, grow muscle and tonify kidney and strengthen yin. Because the Chinese yam is rich in various vitamins, amino acids and mineral substances, the Chinese yam can prevent and treat lipid metabolism disorder of a human body and arteriosclerosis, and has a certain effect on maintaining normal functions of insulin. Has the effects of enhancing immunity, benefiting heart, tranquilizing, relieving cough, relieving asthma, and delaying aging.
The invention takes sealwort, tuckahoe, mulberry and medlar as monarch drugs and balsam pear, kudzu root, mulberry leaf and yam as ministerial drugs; rhizoma Polygonati Odorati, flos Chrysanthemi Indici, semen Cassiae, and thallus laminariae as adjuvant drugs; semen coicis, fructus angelicae, oyster, semen cassiae, peach kernel and endothelium corneum gigeriae galli are used as guiding drugs.
Wherein the content of the first and second substances,
the invention adopts rhizoma polygonati, tuckahoe, mulberry and medlar as monarch drugs, and the diabetes is based on yin deficiency and has deficiency of five internal organs; dryness-heat as the index of the heat damaging the body fluids; the four monarch drugs are used together, and the traditional Chinese medicine has the effects of tonifying spleen and stomach, tonifying qi and yin, moistening lung and tonifying kidney, promoting the production of body fluid to quench thirst, calming heart and tranquilizing mind and the like. On the basis of tonifying the deficiency of five internal organs, the traditional Chinese medicine composition can restore the pancreatic function, increase the insulin activity, regulate the insulin secretion and effectively improve the symptoms of diabetes mellitus such as more than three, one and less than three.
The balsam pear, the kudzu root, the mulberry leaf and the Chinese yam are used as ministerial drugs, the main component of the balsam pear is plant insulin which is an effective blood sugar regulator, and the kudzu root, the mulberry leaf and the Chinese yam have good blood sugar regulating effect, can regulate the secretion function in a body, promote the metabolism of the body, activate the function of the pancreas β cells, improve the biological response effect of the insulin and assist monarch drugs to play roles.
The invention adopts polygonatum, wild chrysanthemum, cassia seed and kelp as adjuvant drugs, and has the effects of nourishing yin, moistening dryness, clearing liver, reducing fat, expelling toxin and the like. Can effectively improve the ecological environment in the body of a patient and promote the medicine of monarch and minister to better play the role.
The invention adopts hawthorn, coix seed, oyster, common yam rhizome, peach seed and chicken's gizzard-membrane as guiding drugs; has the effects of nourishing cell tissues, improving immunity, improving microcirculation, dredging blood vessels, improving digestive function and the like, and has the effect of comprehensively conditioning diabetes and complications by cooperating with the above components, thereby being beneficial to the recovery of patients.
Compared with the prior art, the invention has the beneficial effects that:
1. the product focuses on dietetic therapy and health preservation, adopts a large compound traditional Chinese medicine food material raw material formula and carries out scientific and reasonable compatibility, so that the food material raw materials have mutual promotion effects, have the treatment effect of medicines and the health preservation effect of foods, are integrated in medicine and food, are combined in treatment and health preservation, and can achieve the effect which cannot be realized by simple medicines.
2. The medicinal and edible food prepared according to the method of the invention has the following advantages: (1) the unique sugar-reducing mechanism is as follows: the invention can effectively activate 'inert' insulin and reduce blood sugar. Some of the insulins from diabetic patients have structural defects, loss of insulin activity, and failure to function properly, and are called "inert" insulins. The insulin prepared by the invention can restore the activity, normally participate in glucose metabolism, improve the utilization and transformation capability of the human body to blood sugar, and achieve the purpose of stably reducing the blood sugar. (2) Can play the protective action to the islet: protecting islet cells and inhibiting islet failure; when insulin which can participate in sugar metabolism is increased, the pancreatic islets do not need to secrete excessive insulin as before, the burden of the pancreatic islets is reduced, necessary adjustment is obtained, and the functions of protecting the pancreatic islets and inhibiting pancreatic islet failure are further achieved. (3) The safety is good: can alleviate drug dependence; the islets are recuperated, the functions of the existing islets are gradually recovered, the self-regulation capability on blood sugar is enhanced, the dependence of the organism on the medicine is correspondingly lightened, and the patient can reduce or stop taking the medicine on the basis. (4) The cooperativity is good: the product can effectively correct three kinds of metabolic disorders and prevent the generation of complications. The improvement of the conversion and utilization capacity of the blood sugar can not only effectively improve the sugar metabolism disorder, but also play a positive role in adjusting the fat and protein metabolism disorder. Is beneficial to supplement daily nutrition, can enhance the physique of patients, and delay and reduce the generation of complications.
3. The medicinal and edible food prepared according to the method of the invention has the following advantages: (1) and supporting the body resistance to consolidate the constitution: the food with homology of medicine and food prepared according to the method of the invention contains effective ingredients of traditional Chinese medicines and rich nutrient substances, can comprehensively improve the immunity of patients, adjust the balance of yin and yang of organisms, enhance the resistance, integrate the functions of strengthening body resistance, invigorating pulse, strengthening body, reducing blood sugar and repairing into a whole, comprehensively promote the recovery of the functions of the organisms and fundamentally condition various typical symptoms and common complications of the diabetics caused by deficiency of qi and yin and imbalance of blood sugar. (2) Improving the insulin content: the balsam pear is taken as one of the formulas, the balsam pear is called as oral traditional Chinese medicine insulin, and the balsam pear insulin contained in the balsam pear has the functions of protecting and repairing diabetic islet B cells and can promote insulin secretion, thereby improving glycometabolism and reducing blood sugar; not only can directly supplement insulin, but also can activate and repair islet cells, so that the pancreas can recover the normal function of secreting insulin. (3) Increasing insulin sensitivity: insulin resistance is an important characteristic of pathogenesis of type 2 diabetes, insulin in a body of most patients is not deficient, but the biological effect of unit insulin is reduced, namely, the insulin sensitivity is reduced, the effective components of balsam pear, rhizoma polygonati and radix puerariae in the raw materials can increase the number of insulin receptors and the binding force between insulin and the receptors, so that the insulin sensitivity is improved, the function of pancreatic island is gradually recovered, the regulating capability of the pancreatic island to blood sugar is enhanced, and the western medicines can be gradually reduced or stopped being taken by the patients. (4) And controlling complications: on the basis of comprehensively improving the immunity of the organism and recovering and controlling the insulin secretion function, the physiological functions of three systems of endocrine, microcirculation and immunity are comprehensively regulated, the conversion and utilization capacity of blood sugar is improved, the sugar metabolism disorder is effectively improved, the complications are cured, and the aims of comprehensively regulating and treating both principal and secondary aspects of diseases are fulfilled. (5) Green therapy: the product is a food therapy product with homology of medicine and food, is a medicine and a food, integrates the medicine with food and medicine, and has the treatment effect of the medicine and the nutritional effect of the food. The traditional Chinese medicine composition is safe and efficient, does not damage liver and kidney, is green and nursing, has no toxic or side effect, enables treatment and health preservation to be carried out synchronously, creates a unique and novel treatment and health preservation combined new therapy, and has a unique effect of treating both symptoms and root causes for diabetes. In addition, after the medicinal and edible food prepared by the method is taken, the food is not required to be restricted intentionally, and the food is eaten when people want to eat the food, such as melons, fruits, vegetables, poultry eggs, and various staple and non-staple foods. The food is only required to be eaten in a proper limited amount without excess.
The Chinese medicinal food material with homology of medicine and food is processed into decoction pieces and used as a raw material, so that the Chinese medicinal food material can tonify qi, nourish yin, promote the production of body fluid, moisten dryness, improve the immunity of a body, adjust the secretion function in the body, promote the metabolism of the body, activate the function of pancreas β cells, improve the biological response effect of insulin, adjust blood sugar, prevent and treat various complications, has the unique conditioning effect of treating both symptoms and root causes for diabetes, is safe and efficient, has no toxic or side effect, and can be taken for a long time.
Detailed Description
The present invention will be described in further detail with reference to examples.
Example 1
A traditional Chinese medicine diet therapy product for conditioning diabetes comprises the following raw materials in parts by weight:
650 parts of rhizoma polygonati, 600 parts of radix puerariae, 550 parts of poria cocos and 550 parts of Chinese wolfberry; 500 parts of hawthorn, 480 parts of polygonatum, 450 parts of mulberry and 550 parts of Chinese yam; 350 parts of chrysanthemum, 300 parts of mulberry leaves, 380 parts of common clubmoss herb and 400 parts of kelp; 450 parts of oyster, 500 parts of coix seed, 400 parts of peach seed, 350 parts of chicken's gizzard-membrane, 550 parts of balsam pear and 500 parts of cassia seed.
The preparation method specifically comprises the following steps:
step 1, pretreatment:
sorting the raw materials, removing mildewed and deteriorated raw materials, cleaning, drying and crushing for later use;
step 2, extraction:
weighing the raw materials according to the weight parts, adding the raw materials into an extraction tank, adding solvent purified water into the raw materials according to the volume ratio of the raw materials to the liquid of 1:5, soaking the raw materials for 40 minutes at normal temperature, heating the raw materials to be boiled, decocting the raw materials in boiling water for three times, decocting the raw materials for 30 minutes for the first time, and stabilizing the raw materials for 30 minutes; decocting for 50 minutes for the second time, and stabilizing for 30 minutes; decocting for 40 minutes for the third time, filtering, and mixing the three decoctions to obtain an extract;
the vapor-liquid mixture evaporated in the decoction process is defoamed by a foam catcher, cooled by a condenser and a cooler, and finally reflows to an extraction tank through a vapor-liquid separator;
and step 3, concentrating:
concentrating the extractive solution by a concentrating unit until the specific gravity is 1.10-1.20 to obtain concentrated solution;
and 4, drying:
spray drying the concentrated solution to obtain Chinese medicinal fine powder;
step 5, checking:
sterilizing the Chinese medicinal fine powder by cobalt 60-r ray irradiation, sealing, and storing.
Example 2
A traditional Chinese medicine diet therapy product for conditioning diabetes comprises the following raw materials in parts by weight:
600 parts of rhizoma polygonati, 550 parts of radix puerariae, 500 parts of poria cocos and 500 parts of medlar; 450 parts of hawthorn, 430 parts of polygonatum, 400 parts of mulberry and 500 parts of Chinese yam; 300 parts of chrysanthemum, 250 parts of mulberry leaves, 330 parts of common clubmoss herb and 350 parts of kelp; 400 parts of oyster, 450 parts of coix seed, 350 parts of peach seed, 300 parts of chicken's gizzard-membrane, 500 parts of balsam pear and 450 parts of cassia seed.
The preparation method comprises the following steps: the same as in example 1.
Example 3
A traditional Chinese medicine diet therapy product for conditioning diabetes comprises the following raw materials in parts by weight:
700 parts of rhizoma polygonati, 650 parts of radix puerariae, 600 parts of poria cocos and 600 parts of medlar; 550 parts of hawthorn, 520 parts of polygonatum, 500 parts of mulberry and 600 parts of Chinese yam; 400 parts of chrysanthemum, 350 parts of mulberry leaves, 420 parts of common clubmoss herb and 450 parts of kelp; 500 parts of oyster, 550 parts of coix seed, 450 parts of peach seed, 400 parts of chicken's gizzard-membrane, 600 parts of balsam pear and 550 parts of cassia seed.
The preparation method comprises the following steps: the same as in example 1.
Effect example 1
Totally selecting 100 cases of various diabetics, wherein 15 cases of type I are 15 percent; 85 cases of II type, accounting for 85 percent, 62 cases of men and 38 cases of women; the age is 36-76 years; average 56 years old; the course of disease is 5 months to 18 years; 11 patients with hypertension, 27 patients with hyperlipidemia, 33 patients with heart disease, 6 patients with menstrual disorder and 10 patients with skin pruritus; the 100 diabetic patients had hand numbness, stabbing sensation on the shoulder, neck, back and arm, frequent nocturia, blurred vision, and other symptoms. Of these, 59 patients had been treated with western medicines and had poor results. The clinical preparations prepared in the embodiments 1 to 3 of the present invention were continuously taken by the above 100 patients with diabetes for 1 month and 3 times a day; after the medicine is taken for 1 month, the effect is judged and counted, and the result is as follows: 58 cases are basically cured, and the proportion is 58 percent; obviously improves 21 cases, and the proportion is 21 percent; 13 cases are improved, the proportion is 13%, the effect is not obvious 8 cases, and the proportion is 8%; the analysis proves that the curative effect is significant.
Wherein the basic cure judgment standard is as follows: the blood sugar is controlled stably, the fasting blood sugar is reduced to be within the range of 3.9-6.1mmol/L, hand numbness symptoms basically disappear, the needling sensations on the inner sides of the shoulder, neck, back and arms basically disappear, skin wounds heal well in normal time, the nocturia frequency is obviously reduced, the visual objects are obviously clear compared with the prior art, the spirit is obviously plump, and no obvious emaciation or obesity is found.
The judgment criteria for significant improvement are: the fasting blood sugar is reduced to be within the range of 6.1-7.0mmol/L, the hand anesthesia time is obviously shortened and can not be frequently felt, the hand anesthesia feeling is obviously light, the acupuncture feeling of the inner sides of the shoulder, the neck, the back and the arms is obviously light, the acupuncture time is obviously shortened, the skin wound is obviously healed in normal time, the nocturia frequency is reduced, the visual objects are clear relatively to the past, the spirit is full, and the emaciation or the obesity with larger amplitude is basically not found.
The improvement judgment standard is as follows: the fasting blood sugar is reduced to be within the range of 6.6-7.6mmol/L, the random blood sugar is occasionally within the range of 10.1-12.1 mmL, most values are lower than the range, the hand anesthesia time is shortened, occasionally, the hand anesthesia is not felt, the needle prick feeling of the shoulder, neck, back and inner side of arm is light, the needle prick feeling time is shortened, the skin wound is obviously healed in normal time, the nocturia frequency is reduced, the visual object is improved relatively to the prior art, the spirit is improved, and no emaciation or obesity is caused to a great extent in a certain period of time.
The judgment criteria for unobvious effects are: although the fasting blood glucose value is improved a little, the fasting blood glucose value is still above 7.0mmol/L, the random blood glucose value is improved a little, the random blood glucose value is still above 11.1mmol/L, the hand numbness symptom is still not obviously relieved, the acupuncture feeling on the inner sides of the shoulder, neck, back and arms is still not obviously relieved, the healing condition of skin wounds in normal time is still not ideal, the nocturia frequency is not obviously improved, the visual objects do not obviously feel clear relatively before, the spirit is not obviously improved, the weight still continues to decline, and the tendency of continuous obesity is still presented.
The embodiments described above are only preferred embodiments of the invention and are not exhaustive of the possible implementations of the invention. Any obvious modifications to the above would be obvious to those of ordinary skill in the art, but would not bring the invention so modified beyond the spirit and scope of the present invention.

Claims (5)

1. A traditional Chinese medicine diet therapy product for conditioning diabetes is characterized by comprising the following raw materials in parts by weight:
600-700 parts of rhizoma polygonati, 550-650 parts of radix puerariae, 500-600 parts of poria cocos and 500-600 parts of medlar; 450-550 parts of hawthorn, 430-530 parts of polygonatum, 400-500 parts of mulberry and 500-600 parts of Chinese yam; 300-400 parts of chrysanthemum, 250-350 parts of mulberry leaves, 330-530 parts of common anemarrhena fruit and 350-450 parts of kelp; 400-500 parts of oyster, 450-550 parts of coix seed, 350-450 parts of peach seed, 300-400 parts of chicken's gizzard-membrane, 500-600 parts of bitter gourd and 450-550 parts of cassia seed.
2. The traditional Chinese medicine dietary therapy product for conditioning diabetes mellitus according to claim 1, is characterized by comprising the following raw materials in parts by weight:
650 parts of rhizoma polygonati, 600 parts of radix puerariae, 550 parts of poria cocos and 550 parts of Chinese wolfberry; 500 parts of hawthorn, 480 parts of polygonatum, 450 parts of mulberry and 550 parts of Chinese yam; 350 parts of chrysanthemum, 300 parts of mulberry leaves, 380 parts of common clubmoss herb and 400 parts of kelp; 450 parts of oyster, 500 parts of coix seed, 400 parts of peach seed, 350 parts of chicken's gizzard-membrane, 550 parts of balsam pear and 500 parts of cassia seed.
3. The preparation method of the traditional Chinese medicine diet therapy product for conditioning diabetes mellitus according to any one of claims 1 to 2, which is characterized by comprising the following steps:
step 1, pretreatment:
sorting the raw materials, removing mildewed and deteriorated raw materials, cleaning, drying and crushing for later use;
step 2, extraction:
weighing the raw materials according to the weight parts, adding the raw materials into an extraction tank, adding solvent purified water into the raw materials according to the volume ratio of the raw materials to the liquid of 1:5, soaking the raw materials for 40 minutes at normal temperature, heating the raw materials to be boiled, decocting the raw materials in boiling water for three times, decocting the raw materials for 30 minutes for the first time, and stabilizing the raw materials for 30 minutes; decocting for 50 minutes for the second time, and stabilizing for 30 minutes; decocting for 40 minutes for the third time, filtering, and mixing the three decoctions to obtain an extract;
the vapor-liquid mixture evaporated in the decoction process is defoamed by a foam catcher, cooled by a condenser and a cooler, and finally reflows to an extraction tank through a vapor-liquid separator;
and step 3, concentrating:
concentrating the extractive solution by a concentrating unit until the specific gravity is 1.10-1.20 to obtain concentrated solution;
and 4, drying:
spray drying the concentrated solution to obtain Chinese medicinal fine powder.
4. The preparation method of the traditional Chinese medicine dietary therapy product for conditioning diabetes mellitus according to claim 3, is characterized by further comprising the following steps of 5 and inspection: sterilizing the Chinese medicinal fine powder by cobalt 60-r ray irradiation, sealing, and storing.
5. The method for preparing a Chinese medicinal diet therapy product for conditioning diabetes mellitus as recited in claim 3, wherein in step 2, the vapor-liquid mixture evaporated during the decoction process is defoamed by a foam catcher, cooled by a condenser and a cooler, and finally reflowed to the extraction tank through a vapor-liquid separator.
CN201911341792.8A 2019-12-24 2019-12-24 Traditional Chinese medicine food therapy product for conditioning diabetes and preparation method thereof Withdrawn CN110882362A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115530373A (en) * 2022-10-11 2022-12-30 重庆深山生物科技有限公司 Health food suitable for diabetic patients and preparation method thereof

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115530373A (en) * 2022-10-11 2022-12-30 重庆深山生物科技有限公司 Health food suitable for diabetic patients and preparation method thereof
CN115530373B (en) * 2022-10-11 2023-08-15 重庆深山生物科技有限公司 Health food suitable for diabetics and preparation method thereof

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Application publication date: 20200317