CN106853229A - Chinese medicinal formulae of prevention and treatment diabetes and diabetic complications and preparation method thereof - Google Patents

Abstract

Chinese medicinal formulae the invention discloses a kind of prevention and treatment diabetes and diabetic complications and preparation method thereof.The Chinese medicinal formulae includes the bark of eucommia, ginseng, the bighead atractylodes rhizome, the windproof, Radix Astragali, cape jasmine, mulberry leaf, leech, Chinese yam, the bark of ash, balsam pear, the root of kudzu vine, the tuber of dwarf lilyturf, the wind-weed, coix seed, the dried rhizome of rehmannia, processs the membrane of a chicken's gizzard, fig, ghost and see plumage, the root bark of Chinese wolf-berry, aloe essence, cactus, desmodium, Lygodium japonicum, Fructus Corni, Waxy wheat, corn stigma, purslane, Jiao's paddy malt, dried human placenta, Bombyx Batryticatus (parched), rhizoma zingiberis and root of Chinese trichosanthes.Its preparation method is：Weigh above-mentioned medicinal material and clean, decocting twice, into flowing soaking paste, shakes up after being diluted three times after warm water immersion, obtains medicinal extract；By the storage of medicinal extract cryogenic seal or spraying drying powder-forming.This Chinese medicine composition is directed to type-II diabetes patient, and its hypoglycemic effect is similar with melbine, reduces adverse reaction rate aspect and is then substantially better than the Western medicine such as melbine, Acarbose.

Description

Chinese medicinal formulae of prevention and treatment diabetes and diabetic complications and preparation method thereof

Technical field

Chinese medicine preparation and preparation method thereof the invention belongs to treat and prevent diabetes, and in particular to it is a kind of prevent and treatment diabetes and diabetic complications Chinese medicinal formulae and preparation method thereof.

Background technology

When body cannot normally with sugared part when just generate diabetes.If enough insulin cannot be secreted from intraperitoneal B cell, or when insulin can not give full play to hypoglycemic physiological action in vivo, the food that we are absorbed, through digesting and assimilating, the glucose for changing into, will largely accumulate, and at this moment blood glucose rise inevitably constitutes diabetes naturally.Because the diabetes origin cause of formation is a lot, every patient's state of an illness is also different.Therapeutic modality is even more and varies with each individual.Therefore, diabetes are a kind of diseases, not as good as thinking that it is a kind of complexity big internal disease very high.Can not push away the medicine of similar melbine always due to the traditional Chinese medical science, hypoglycemic effect is not protruded, therefore can only be auxiliary treatment.All the time, treating diabetes are based on doctor trained in Western medicine, Therapeutic mode then to intervene based on blood sugar, patient can only Long-term taking medicine, survive in spite of illness.Greatest pain is brought to sufferer colony, taking for long-term Western medicine brings huge side effect, and the organ to liver kidney causes serious damage.

Modern type-II diabetes most patients are and in the majority with overweight person without typical three-many-one-little disease.Treatment it is such disease first recorded in《The Yellow Emperor's Canon of Internal Medicine》.《Plain Questions-strange disease opinion》Say：" this fertile institute's hair, it is sweet and refreshing and how fertile that this person must count food, and fertile person makes swelling of REN ZHONG, therefore its gas overflow, switch to quench one's thirst." Yuan Dynasty's Zhu Zhenheng《Danxi's experiential therapy》Say：" without section, cruel thermophilic moxibustion, internal organs heat is scorching flourishing in wine face ", this is one of important mechanism that diabetes develop.Modern general food high heat, high protein crowd are more and more, and these food are more long in the dirty RT of stomach, easily cause stomach to have one's mind filled with swollen, long then stomach protuberance.Excessive nutriment enters liver from small intestine in addition, and processing and store is absorbed through liver, and is transported to remaining organ by blood, and superfluous nutriment increases blood viscosity, causes fat accumulation, overweight.And then liver, courage, stomach are hot and suffocating, Gastrointestinal excess heat makes swelling of REN ZHONG, and gas overflows up, is converted into type-II diabetes typical sign.For this interpretation of the cause, onset and process of an illness, with balsam pear, the coptis, cactus, aloe as monarch in side.Taking its, cold clear its is hot and suffocating；Its bitter taste is taken, it is sweet to press down its, the purpose of blood sugar is reduced so as to reach.Cactus moistens heat-clearing, aloe clearing away heat and loosing the bowels simultaneously, and monarch drug in a prescription collective effect makes heat be discharged from stool, makes the full abdomen sense of depression quick disappearance of overweight people.In daily life, also there are numerous diabetic's eating balsam pears, with up to the purpose of dietotherapy hypoglycemic.Modern pharmacological research proves that cactus, aloe, balsam pear have good blood sugar reducing function, and domestic and international this respect special report is much.

Although diabetes are a diversity complex diseases, but hypoglycemic is still a unavoidable key problem.Western medicine hypoglycemic mechanism is simply clear, as long as blood sugar is lowered, is then played a role using other medicines as complication, complication, side effect.Chinese medicine does not have so simply then, does not find that only taking a herb can just control " celestial grass " of blood sugar also.The logos of Chinese traditional treatment is, on the basis of many diseases of diabetes are thought better of, comprehensive reference western medicine pathologic, physiologic Testing index, then according to medicine nature and flavor, return through, effect, legislation ancestor side, carries out macroscopical wholistic therapy.

The content of the invention

The present invention is proposed to overcome shortcoming present in prior art, the purpose is to providing a kind of prevention and treating Chinese medicinal formulae of diabetes and diabetic complications and preparation method thereof.

The technical scheme is that：

A kind of Chinese medicinal formulae for preventing and treating diabetes and diabetic complications, the Chinese medicinal formulae is made by the raw material of following parts by weight：

6 ~ 30 parts of the bark of eucommia,2 ~ 8 parts of ginseng,6 ~ 15 parts of the bighead atractylodes rhizome,Windproof 6 ~ 15 parts,8 ~ 30 parts of the Radix Astragali,4 ~ 20 parts of cape jasmine,10 ~ 30 parts of mulberry leaf,2 ~ 12 parts of leech,8 ~ 30 parts of Chinese yam,10 ~ 30 parts of the bark of ash,10 ~ 80 parts of balsam pear,10 ~ 30 parts of the root of kudzu vine,6 ~ 15 parts of the tuber of dwarf lilyturf,6 ~ 15 parts of the wind-weed,8 ~ 40 parts of coix seed,10 ~ 50 parts of the dried rhizome of rehmannia,Process 6 ~ 20 parts of the membrane of a chicken's gizzard,8 ~ 40 parts of fig,Ghost is shown in 6 ~ 15 parts of plumage,10 ~ 30 parts of the root bark of Chinese wolf-berry,2 ~ 8 parts of aloe essence,2 ~ 20 parts of cactus,5 ~ 30 parts of desmodium,5 ~ 30 parts of Lygodium japonicum,6 ~ 15 parts of Fructus Corni,10 ~ 100 parts of Waxy wheat,10 ~ 40 parts of corn stigma,10 ~ 30 parts of purslane,10 ~ 30 parts of burnt paddy malt,0.2 ~ 1.5 part of dried human placenta,6 ~ 15 parts of Bombyx Batryticatus (parched),5 ~ 15 parts of rhizoma zingiberis,6 ~ 15 parts of root of Chinese trichosanthes.

A kind of preparation method of the Chinese medicinal formulae for preventing and treating diabetes and diabetic complications, comprises the following steps：

（ⅰ）Weigh 6 ~ 30 parts of the bark of eucommia,2 ~ 8 parts of ginseng,6 ~ 15 parts of the bighead atractylodes rhizome,Windproof 6 ~ 15 parts,8 ~ 30 parts of the Radix Astragali,4 ~ 20 parts of cape jasmine,10 ~ 30 parts of mulberry leaf,2 ~ 12 parts of leech,8 ~ 30 parts of Chinese yam,10 ~ 30 parts of the bark of ash,10 ~ 80 parts of balsam pear,10 ~ 30 parts of the root of kudzu vine,6 ~ 15 parts of the tuber of dwarf lilyturf,6 ~ 15 parts of the wind-weed,8 ~ 40 parts of coix seed,10 ~ 50 parts of the dried rhizome of rehmannia,Process 6 ~ 20 parts of the membrane of a chicken's gizzard,8 ~ 40 parts of fig,Ghost is shown in 6 ~ 15 parts of plumage,10 ~ 30 parts of the root bark of Chinese wolf-berry,2 ~ 8 parts of aloe essence,2 ~ 20 parts of cactus,5 ~ 30 parts of desmodium,5 ~ 30 parts of Lygodium japonicum,6 ~ 15 parts of Fructus Corni,10 ~ 100 parts of Waxy wheat,10 ~ 40 parts of corn stigma,10 ~ 30 parts of purslane,10 ~ 30 parts of burnt paddy malt,0.2 ~ 1.5 part of dried human placenta,6 ~ 15 parts of Bombyx Batryticatus (parched),5 ~ 15 parts of rhizoma zingiberis,6 ~ 15 parts of root of Chinese trichosanthes,Above-mentioned medicinal material is rinsed twice with clear water；

（ⅱ）The medicinal material for completing is cleaned, decocting twice, into flowing soaking paste, shakes up after being diluted three times after warm water immersion, obtains medicinal extract；

（ⅲ）By the storage of medicinal extract cryogenic seal or spraying drying powder-forming.

The Chinese medicinal formulae routinely technique can be made tablet, capsule, granule, dripping pill, micropill, dispersible tablet, oral disnitegration tablet, pill, oral liquid.

The beneficial effects of the invention are as follows：

Chinese medicinal formulae of the present invention, for type-II diabetes patient, hypoglycemic effect is similar with melbine, reduces adverse reaction rate aspect and is then substantially better than the Western medicine such as melbine, Acarbose；Clinical trial certificate, a part of patient only can reduce blood sugar with Chinese medicine within a certain period of time；A part of patient withdraws hypoglycemic Western medicine or removes and subtracts insulin, only can also maintain blood sugar level with Chinese medicine.The present invention broken Chinese medicine can only as the auxiliary treatment of diabetes, or treatment diabetic complications existing situation, for the field that traditional Chinese medicine comes into treatment diabetes provides motive force.

Specific embodiment

Chinese medicinal formulae and preparation method thereof of present invention prevention and treatment diabetes and diabetic complications is described in detail with reference to embodiment：

Embodiment 1

A kind of preparation method of the Chinese medicinal formulae for preventing and treating diabetes and diabetic complications, comprises the following steps：

（ⅰ）Weigh bark of eucommia 6g, ginseng 2g, the bighead atractylodes rhizome 6g, windproof 6g, 8 parts of the Radix Astragali, cape jasmine 4g, mulberry leaf 10g, leech 2g, Chinese yam 8g, bark of ash 10g, balsam pear 10g, root of kudzu vine 10g, tuber of dwarf lilyturf 6g, wind-weed 6g, coix seed 8g, dried rhizome of rehmannia 10g, the membrane of a chicken's gizzard 6g is processed, fig 8g, ghost is shown in plumage 6g, root bark of Chinese wolf-berry 10g, aloe essence 2g, cactus 2g, desmodium 5g, Lygodium japonicum 5g, Fructus Corni 6g, Waxy wheat 10g, corn stigma 10g, purslane 10g, burnt paddy malt 10g, dried human placenta 0.2g, Bombyx Batryticatus (parched) 6g, rhizoma zingiberis 5g, root of Chinese trichosanthes 6g, clear water rinse twice above-mentioned medicinal material；

（ⅱ）The medicinal material for completing is cleaned, decocting twice, into liquid extract, shakes up after being diluted three times after warm water immersion, obtains medicinal extract；

（ⅲ）By medicinal extract spraying drying powder-forming.

Embodiment 2

A kind of preparation method of the Chinese medicinal formulae for preventing and treating diabetes and diabetic complications, comprises the following steps：

（ⅰ）Weigh bark of eucommia 30g, ginseng 8g, bighead atractylodes rhizome 15g, windproof 15g, 30 parts of the Radix Astragali, cape jasmine 20g, mulberry leaf 30g, leech 12g, Chinese yam 30g, bark of ash 30g, balsam pear 80g, root of kudzu vine 30g, tuber of dwarf lilyturf 15g, wind-weed 15g, coix seed 40g, dried rhizome of rehmannia 50g, process the membrane of a chicken's gizzard 20g, fig 40g, ghost is shown in plumage 15g, root bark of Chinese wolf-berry 30g, aloe essence 8g, cactus 20g, desmodium 30g, Lygodium japonicum 30g, Fructus Corni 15g, Waxy wheat 100g, corn stigma 40g, purslane 30g, burnt paddy malt 30g, dried human placenta 1.5g, Bombyx Batryticatus (parched) 15g, rhizoma zingiberis 15g, root of Chinese trichosanthes 15g, clear water rinses twice above-mentioned medicinal material；

（ⅱ）The medicinal material for completing is cleaned, is decocted twice for 100 DEG C after warm water immersion, into liquid extract, shaken up after being diluted three times, obtain medicinal extract；

（ⅲ）By the storage of medicinal extract cryogenic seal

Routinely technique is made tablet, capsule, granule, dripping pill, micropill, dispersible tablet, oral disnitegration tablet, pill, oral liquid to the Chinese medicinal formulae.

（a）Tablet machining process

By xeraphium, the granulation of the auxiliary materials such as cornstarch, magnesium stearate, microcrystalline cellulose, silica, compressing tablet are added；Every sheet weight is 550 milligrams after tablet processing, and wherein crude drug powder is 420 milligrams.

（b）Capsule prilling process

300 milligrams of spray dried powder, 60 milligrams of microcrystalline cellulose are taken, 5 milligrams of silica 1,5 milligrams of magnesium stearate add up to 400 milligrams, No. 0 capsule is loaded after granulation.Specific method is that xeraphium is well mixed with microcrystalline cellulose, adds 80% ethanol to cause suitable softwood, crosses 16 mesh sieve whole grains, adds Sodium Hydroxymethyl Stalcs, silica, magnesium stearate to be well mixed during whole grain；Load No. 0 capsule, and sealing of bottling, keep in dark place.

（c）Suspension processing method

After by the concentration of second decoction liquor, then heat hot filling airtight package bottle, then heating, vacuum treatment.

（d）Dripping pill processing method

By spray dried powder after mechanical process is centrifuged, remove the impurity such as two oxycarbides, remaining micro mist adds auxiliary material, you can be processed into dripping pill.

Effect of Chinese medicinal formulae each component of the present invention is as follows：

The bark of eucommia：It is sweet, it is warm in nature.Return liver, kidney, stomach.Tonify the liver and kidney, strengthen muscles and bones, coordinating Chong and Conception Vessels, controlling nocturnal emission with astringent drugs is antiabortive.

Ginseng：Mild-natured, tepor, sweet, slight bitter.Returns spleen, lung channel, the heart channel of Hang-Shaoyin.Reinforce vital energy, veins takes off admittedly reinforces the spleen to benefit the lung, and promotes the production of body fluid to quench thirst, tranquilize the mind and promote the intelligence.

The bighead atractylodes rhizome：It is bitter, sweet, temperature.Returns spleen, stomach.Tonifying spleen, beneficial stomach, eliminating dampness, and in, it is antiabortive.Deficient QI of the spleen and stomach is controlled, do not feel like eating, the few gas of burnout, empty account, diarrhea, phlegm and retained fluid, oedema, jaundice, arthritis with fixed pain caused by dampness, difficult urination is dizzy, and spontaneous perspiration, nausea is uneasy.

It is windproof：It is pungent, sweet, tepor.Return bladder, lung, spleen, Liver Channel.Expel pathogenic wind from the body surface, win wet analgesic, spasmolysis, antipruritic.

The Radix Astragali：It is sweet, tepor.Return lung, spleen, liver and kidney channel.Enhancing body's immunity, liver protection, diuresis, anti-aging, resisting stress, step-down and wide antibacterial action.

Cape jasmine：Hardship, trembles with fear.The thoughts of returning home, lung, stomach, tri-jiao channel.Heat-clearing, purging intense heat, cool blood.Pyreticosis restlessness of asrhenia type and insomnia is controlled, jaundice, gonorrhoea is quenched one's thirst, hot eyes, pharyngalgia, spitted blood, bleeding from five sense organs or subcutaneous tissue, bloody flux, hematuria, pathopyretic ulcer is sprained and swollen and ache.

Mulberry leaf：It is bitter, sweet, cold in nature.Return lung, Liver Channel.Except fever and chills, perspire.Except tinea pedis, oedema, sharp intestine and small intestine.Soothe sore throat, swelling and aching of gum, head edema.

Leech：Taste is salty, puts down.Enter liver, bladder warp.The diseases such as menstruation apolipsis, abdominal mass are suffered from abdominal pain, storage blood, traumatic blood stasis are had a pain, the swollen erysipelas of pain.

Rhizoma zingiberis：It is pungent, heat.Returns spleen, stomach, kidney, the heart, lung channel.Warming spleen and stomach for dispelling cold, Back to Yang Tongmai, Wenfei of drink.

Chinese yam：It is sweet, flat, it is nontoxic.Returns spleen, lung, kidney channel.Tonifying spleen nourishing the stomach, engender liquid and benefic lung, the puckery essence of kidney tonifying.For spleen eating less, endless diarrhea, the deficiency syndrome of the lung is breathed with cough, and emission due to the kidney deficiency, under band, frequent micturition, abnormal heat is quenched one's thirst.Rhizoma Dioscoreae (parched with bran) good efficacy to suffering from a deficiency of the kidney.For spleen eating less, diarrhea loose stool, leukorrhea.

The bark of ash：Bitter, trembles with fear.Return liver warp, gallbladder channel, large intestine channel.Heat-clearing and damp-drying drug, clear liver and improve vision, inducing astrigency stop dysentery, stop-band.

Balsam pear：Bitter, it is nontoxic, it is cold in nature.The thoughts of returning home, liver, spleen, lung channel.With clearing summer heat, improving eyesight removing toxic substances, reducing pressure and sugar, diuresis cool blood, solution labor clear away heart-fire, QI invigorating establishing-Yang the effect of.

The root of kudzu vine：It is sweet, pungent, it is cool.Returns spleen, stomach.Expelling pathogenic factors from muscles and skin is brought down a fever, and is promoted the production of body fluid, promoting eruption, Shengyang Zhixie.

Bombyx Batryticatus (parched)：It is flat, it is salty.Return liver, lung channel.Dispelling wind and relieving convulsion, reducing phlegm and resolving masses.Treatment convulsion, abscess of throat, pruitus；Submandibular lymph nodes is scorching, facioplegia.

Root of Chinese trichosanthes：Slight bitter, is slightly cold.Attach to the lung and stomach meridians.Clearing heat and promoting fluid, detumescence and apocenosis.

The tuber of dwarf lilyturf：Sweet, slight bitter, is slightly cold.The thoughts of returning home, lung, stomach.Nourishing Yin and promoting production of body fluid, moistening lung clears away heart-fire.Treatment dryness of the lung dry cough, cough for deficiency of Yin consumptive disease, larynx numbness pharyngalgia, injury thirst, Heat Diabetes, vexed insomnia, dry constipation of intestines.

The wind-weed：Bitter, trembles with fear.Enter lung, stomach, kidney channel.Nourishing Yin and falling fire, moisturize laxation.Control dysphoria with smothery sensation to quench one's thirst, hectic fever due to yin labor heat, cough with lung heat, dry feces, difficult urination.

Coix seed：It is cool in nature, it is sweet, light.Returns spleen is passed through.Invigorating the spleen excreting dampness, remove numbness antidiarrheal.Treatment oedema, tinea pedis, difficult urination, arthritis with fixed pain caused by dampness contraction, splenasthenic diarrhea.

The dried rhizome of rehmannia：It is sweet, cold.The thoughts of returning home, liver and kidney channel.Clearing heat and cooling blood.Treatment warm heat disease heat enters ying blood, and high fever coma, dry tongue is deep red.Control warm heat disease heat and enter ying blood, blood-heat and toxin exuberance, hematemesis and epistaxis, atropurpureus macula.

Process the membrane of a chicken's gizzard：It is sweet, tremble with fear.Returns spleen, stomach, small intestine, bladder warp.Children's food malaria is controlled, treatment adult is dripping, gastric disorder causing nausea, the wine that disappears product, main larynx is closed, acute tonsillitis, all aphthas, all sores of noma.

Fig：It is sweet, it is cool in nature.Lung, stomach, large intestine channel.Invigorating stomach and promoting bower movements, subdhing swelling and detoxicating.Control enteritis, dysentery, constipation, hemorrhoid, laryngalgia, ulcerative carbuncle mange, throat, expelling parasite of whetting the appetite.

Ghost is shown in plumage：Hardship, trembles with fear, nontoxic.Thoughts of returning home warp.It is clearing heat and detoxicating, cooling blood and hemostasis.Treatment influenza, heatstroke stomachache, body hair eruptive syndrome, typhoid fever, epilepsy, skin liver wind toxin swells and ache.

The root bark of Chinese wolf-berry：It is cold in nature, it is sweet.Return lung, liver and kidney channel.Cool blood is except steaming, clearing lung-heat fall fire.Treatment deficiency of Yin hectic fever, hectic fever due to yin night sweat, cough with lung heat, spitting of blood, bleeding from five sense organs or subcutaneous tissue.

Aloe essence：Hardship, trembles with fear.Return lung, large intestine channel.Clearing away heat and loosing the bowels, clearing liver relieving restlessness, destroying parasites for curing malnutrition.Treatment constipation with heat retention, infantile malnutrition, pruitus.

Cactus：It is cold in nature, it is bitter, puckery.The thoughts of returning home, lung, stomach three are passed through.It is clearing heat and detoxicating, stimulate the circulation of the blood and cause the muscles and joints to relax, eliminating stasis to subdue swelling, solution intestines poison, cooling blood and relieving pain, ease constipation hemostasis, benefiting stomach and stopping pain, antibechic.Treatment taste-blindness rate, hemorrhoid, acute dysentery, cough；Mumps, mastitis, carbuncle furuncle poison, external piles, snake bite, burn and scald are controlled in external application.

Desmodium：Sweet, slight bitter, it is cool in nature.Return liver, courage, kidney, bladder warp.Promoting diuresis for stranguria；It is clearing heat and detoxicating；Eliminating stasis to subdue swelling.Cure mainly liver and gall and stone in urinary system, heat gonorrhea, nephritic dropsy, jaundice with damp-heat pathogen, sore carbuncle swells, venomous snake bite, traumatic injury.

Lygodium japonicum：It is sweet, light, it is cold in nature, it is nontoxic.Return small intestinl channel, bladder warp.There is tonneau small intestine, fever and chills of curing the wound are mad, control damp and hot pyogenic infections, urine heat gonorrhea cream drenches blood strangury, urolithiasis dysmenorrhoea, antipyretic poison gas.

Fructus Corni：Tepor；It is sour, puckery.Return liver and kidney channel.Liver and kidney benefiting, convergence is solid de-.Cure mainly waist to have a dizzy spell, deafness and tinnitus, soreness and weakness of waist and knees, Xian essence involuntary emission, frequent urination, incessant sweating due to debility, woman uterine bleeding, Heat Diabetes, warm liver kidney tonifying, except a wind cutting, only menorrhalgia, punish-old people's frequent micturition.

Waxy wheat：It is sweet, it is cold in nature, it is nontoxic.New wheat property heat, old wheat is mild-natured.Except heat, only polydipsia, dry throat.Diuresis, take a tonic or nourishing food to build up one's health irritability, and leak-stopping blood spitting blood can make woman be easy to pregnancy.Benefiting heart-QI.

Corn stigma：It is flat, it is sweet, light.Return bladder, liver, gallbladder channel.Expel the heat-evil treating stranguria, soothing the liver cholagogic.Gall stone, cholecystitis, diabetes.

Herba portulacae：It is cold in nature, sweet acid.Thoughts of returning home warp, Liver Channel, the spleen channel, large intestine channel.Clearing heat and detoxicating, cooling blood and hemostasis.

Burnt paddy malt：It is sweet, flat.Returns spleen, stomach, Liver Channel.Promoting the circulation of qi helps digestion, spleen benefiting and stimulating the appetite, moves back newborn dissipate-swelling.

Dried human placenta：Nature and flavor are sweet, salty, temperature.Return lung, the heart, kidney channel.Feel at ease blood-nourishing, QI invigorating, mend essence, removing toxic substances etc..

Chinese medicinal formulae in the present invention is made up of 28 taste Chinese medicines, mainly for disease type legislation ancestor sides such as extreme heat due to deficiency of yin caused by diabetic's heat Sheng, the deficiency of Yin, the deficiency of vital energy, the deficiency of yang, deficiency of both qi and yin, the double void of negative and positive.

The formula of Chinese medicinal formulae of the present invention by《Danxi's experiential therapy》、《Jing Yue's complete work》、《Thorough Knowledge of Medicine》Formed Deng the prescription addition or subtraction of changes in works.

Modern pharmacological research proves that cactus, aloe, balsam pear have good blood sugar reducing function.

Bitter and cold medicines have heat-clearing blood sugar reducing function, and this point is unquestionable, but Long-term taking medicine is feared stomach and intestine are caused to damage.Gu Zuo helps monarch drug in a prescription, it is to avoid the excessive massacre of bitter and cold medicines is too heavy with rhizoma zingiberis, burnt paddy malt, the moxibustion the membrane of a chicken's gizzard, fig, Semen Coicis, Bombyx Batryticatus (parched) as minister.Pungent, the heat of rhizoma zingiberis, warming spleen and stomach for dispelling cold；Burnt paddy malt relieving dyspepsia, promoting the circulation of qi dissipate-swelling；The membrane of a chicken's gizzard is sweet flat, stomach strengthening and digestion promoting；Fig is mild-natured, sweet, invigorating stomach and promoting bower movements, treats diarrhoea；Rhizoma Atractylodis Macrocephalae preparata and stomach, strengthening the spleen and replenishing qi.

The root of kudzu vine, mulberry leaf, the dried rhizome of rehmannia, the root bark of Chinese wolf-berry, the bark of eucommia, folium panacis japonici cum caule, Fructus Corni, rhizoma atractylodis, the tuber of dwarf lilyturf, the wind-weed, root of Chinese trichosanthes, dried human placenta, stiff silkworm, Semen Coicis etc. are adjutant in side.While blood sugar is reduced, many diabetic complicationses are alleviated and adjusted to supplementing qi and nourishing yin, sweet void of filling up deficit to all medicines in side.From property function analysis, above-mentioned Chinese medicine can both alleviate the disease of virtual loss, the time of cloudy liquid in-fighting can have been reduced again.Combination of Chinese tradiational and Western medicine founder, the Republic of China name doctor Mr. Zhang Xichun think, caused by three eliminating masses are deficiency of spleen-YIN, therefore with the dried rhizome of rehmannia, the root bark of Chinese wolf-berry, the tuber of dwarf lilyturf, the big tonifying spleen-yin of Chinese yam, the wind-weed can hard lower Jiao cloudy and remove heat；Folium panacis japonici cum caule in another side, the bark of eucommia, dried human placenta can kidney nourishing and strengthening, obtaining helping for the root of kudzu vine can rise vigour, and assistant knows the moon with the in love product such as Chinese yam, the wind-weed, dried human placenta with enriching yin again, be allowed to Yang Sheng and it is cloudy should.Promoted the production of body fluid with folium panacis japonici cum caule's tonifying Qi in side, bark of eucommia filling liver kidney, dried human placenta nourishing qi and blood, temperature compensation kidney essense, it is taken with Fructus Corni acid and nourishing liver and kidney with sealing kidney pass, multiple its negative and positive, to reduce frequent micturition, Urine proteins, yin-yang deficiency type etc. is slightly weighed diabetic and alleviated.Semen Coicis are sweet light cool in other side, reducing phlegm and resolving masses；Bombyx Batryticatus (parched) is salty pungent flat, dispelling wind and relieving convulsion, reducing phlegm and resolving masses, clearing away heat and eliminating pus.Two medicines can eliminate diabetic's femoral neck itch with use, reduce the pain of diabetic.Additionally, the Chinese medicine such as Lygodium japonicum, the bark of ash, leech, desmodium, the Radix Astragali, windproof, corn stigma, purslane is to make medicine in side.It is have collective effect to microcirculation in human body system that this group of medicine has a common feature.Desmodium reducing fever and causing diuresis, can subside a swelling；Lygodium japonicum inducing diuresis for treating strangurtia, prevents urinary tract infections；Herba portulacae is clearing heat and detoxicating, radiating detumescence, only quenches one's thirst；Bark of ash heat-clearing and damp-drying drug, can promote uric acid salt excretion；Leech, property is salty bitter flat, and dissipating blood stasis with potent drugs is stimulated the menstrual flow, and network is hindered in diabetes prolonged illness, once logical using necessarily warp, improves local microcirculation.Corn stigma is mild-natured, and sweet light, diuresis expels the heat-evil, soothing the liver cholagogic, it is possible to decrease hyperglycaemia, hypertension.Rhizoma Atractylodis Macrocephalae preparata in we, the Radix Astragali, it is windproof be originally a square foundation --- Yupingfeng San, be the classics side of enhance immunity.Though diabetes are metabolic diseases, there is great relevance with immunity of organisms, the features of the present invention also resides in the immunity for improving diabetic, strengthens itself resistance against diseases, plays the role of for the recovery of diabetes irreplaceable.In a word, compatibility of medicines in a prescription rigorous and scientific of the invention, persistently, zoopery and Clinical practice have no any toxic and side effect to blood sugar reducing function, are fully available for the prevention and treatment of diabetes and diabetic complications.

Inside and outside experimental studies results show that Chinese medicinal formulae of the present invention has obvious action to Non-Insulin Dependent Diabetes Mellitus and diabetic complications.SGLT2 suppresses experiment and diabetes DB model mice animal experiments etc. to be proved, prescription high dose of the present invention can make diabetes DB mouse blood sugars return normal level in 45 days, and glycosylated hemoglobin is reduced in various degree, be coincide substantially with clinical treatment outcome., it was demonstrated that prescription of the present invention can be used for the treatment of Non-Insulin Dependent Diabetes Mellitus, and can the complication that causes of prophylactic treatment diabetes therefore.

, from the angle of theory of traditional Chinese medical science, for the universal pathogenesis of diabetes, prescription dispensing is sweet with hardship suppression with heat-clearing of trembling with fear, and is moisturized with cool, full with the system that disappears, turbid to wash drop, empty with tonic for the present invention.A large amount of clinical effectivenesses prove that taking above method to be reached within certain treatment time effectively reduces the purpose of blood sugar, general therapeutic three months or so, and glycosylated hemoglobin also can surely be decreased obviously.

The clinical treatment outcome of prescription of the present invention shows that insulin injection simultaneously with more than the two kinds patients of western medicine are taken, after being treated three months through prescription of the present invention, can substitute the use of Western medicine with decrement or completely.For the patient of long-term taking prescription of the present invention, the gradually injection dosage of decrement insulin, blood sugar can still maintain normal level.It is more long for diabetic duration, start to occur that shank leg is livid purple, cirsoid patient took prescription of the present invention after three months, and leg color and varication are returned to normal.

Claims (3)

1. it is a kind of prevent and treatment diabetes and diabetic complications Chinese medicinal formulae, it is characterised in that：The Chinese medicinal formulae is made by the raw material of following parts by weight：

6 ~ 30 parts of the bark of eucommia,2 ~ 8 parts of ginseng,6 ~ 15 parts of the bighead atractylodes rhizome,Windproof 6 ~ 15 parts,8 ~ 30 parts of the Radix Astragali,4 ~ 20 parts of cape jasmine,10 ~ 30 parts of mulberry leaf,2 ~ 12 parts of leech,8 ~ 30 parts of Chinese yam,10 ~ 30 parts of the bark of ash,10 ~ 80 parts of balsam pear,10 ~ 30 parts of the root of kudzu vine,6 ~ 15 parts of the tuber of dwarf lilyturf,6 ~ 15 parts of the wind-weed,8 ~ 40 parts of coix seed,10 ~ 50 parts of the dried rhizome of rehmannia,Process 6 ~ 20 parts of the membrane of a chicken's gizzard,8 ~ 40 parts of fig,Ghost is shown in 6 ~ 15 parts of plumage,10 ~ 30 parts of the root bark of Chinese wolf-berry,2 ~ 8 parts of aloe essence,2 ~ 20 parts of cactus,5 ~ 30 parts of desmodium,5 ~ 30 parts of Lygodium japonicum,6 ~ 15 parts of Fructus Corni,10 ~ 100 parts of Waxy wheat,10 ~ 40 parts of corn stigma,10 ~ 30 parts of purslane,10 ~ 30 parts of burnt paddy malt,0.2 ~ 1.5 part of dried human placenta,6 ~ 15 parts of Bombyx Batryticatus (parched),5 ~ 15 parts of rhizoma zingiberis,6 ~ 15 parts of root of Chinese trichosanthes.

2. according to a kind of prevention described in claim 1 and the preparation method of the Chinese medicinal formulae for the treatment of diabetes and diabetic complications, it is characterised in that：Comprise the following steps：

（ⅰ）Weigh 6 ~ 30 parts of the bark of eucommia,2 ~ 8 parts of ginseng,6 ~ 15 parts of the bighead atractylodes rhizome,Windproof 6 ~ 15 parts,8 ~ 30 parts of the Radix Astragali,4 ~ 20 parts of cape jasmine,10 ~ 30 parts of mulberry leaf,2 ~ 12 parts of leech,8 ~ 30 parts of Chinese yam,10 ~ 30 parts of the bark of ash,10 ~ 80 parts of balsam pear,10 ~ 30 parts of the root of kudzu vine,6 ~ 15 parts of the tuber of dwarf lilyturf,6 ~ 15 parts of the wind-weed,8 ~ 40 parts of coix seed,10 ~ 50 parts of the dried rhizome of rehmannia,Process 6 ~ 20 parts of the membrane of a chicken's gizzard,8 ~ 40 parts of fig,Ghost is shown in 6 ~ 15 parts of plumage,10 ~ 30 parts of the root bark of Chinese wolf-berry,2 ~ 8 parts of aloe essence,2 ~ 20 parts of cactus,5 ~ 30 parts of desmodium,5 ~ 30 parts of Lygodium japonicum,6 ~ 15 parts of Fructus Corni,10 ~ 100 parts of Waxy wheat,10 ~ 40 parts of corn stigma,10 ~ 30 parts of purslane,10 ~ 30 parts of burnt paddy malt,0.2 ~ 1.5 part of dried human placenta,6 ~ 15 parts of Bombyx Batryticatus (parched),5 ~ 15 parts of rhizoma zingiberis,6 ~ 15 parts of root of Chinese trichosanthes,Above-mentioned medicinal material is rinsed twice with clear water；

（ⅱ）The medicinal material for completing is cleaned, decocting twice, into flowing soaking paste, shakes up after being diluted three times after warm water immersion, obtains medicinal extract；

（ⅲ）By the storage of medicinal extract cryogenic seal or spraying drying powder-forming.

3. it is according to claim 1 it is a kind of prevent and treatment diabetes and diabetic complications Chinese medicinal formulae, it is characterised in that：The Chinese medicinal formulae routinely technique can be made tablet, capsule, granule, dripping pill, micropill, dispersible tablet, oral disnitegration tablet, pill, oral liquid.