CN106692845A - Medicament for treating diabetes and preparation method thereof - Google Patents
Medicament for treating diabetes and preparation method thereof Download PDFInfo
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- CN106692845A CN106692845A CN201710139833.XA CN201710139833A CN106692845A CN 106692845 A CN106692845 A CN 106692845A CN 201710139833 A CN201710139833 A CN 201710139833A CN 106692845 A CN106692845 A CN 106692845A
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Abstract
The invention discloses a medicament for treating diabetes and a preparation method thereof. The medicament is prepared from dendrobe, radix ophiopogonis, radix rehmanniae recen, scrophulariae, radix trichosanthis, Chinese yam, radix astragali seu hedysari, rhizoma atractylodis, rhizoma anemarrhenae, cortex phellodendri, dogwood, salviae miltiorrhizae, prepared rehmannia root, herba taxilli, pawpaw, bighead atractylodes rhizome, medicine terminalia fruit, fossil fragments, concha haliotidis, semen cuscutae, alpinia oxyphylla, mantis egg-case, semen platycladi, gypsum, cortex lycii radices, rhizoma imperatae, fructus schizandrae, radix puerariae, endothelium corneum gigeriae galli and radices trichosanthis according to a certain proportion. The medicament has the functions of moisturizing dryness by nourishing yin, clearing away the heart-fire, relieving restlessness, tonifying stomach, promoting fluid, clearing heat, cooling blood, nourishing yin to lessen fire, removing heat and improving eyesight, and has the advantages quick response, good curative effect and prevention of relapse when being applied to treatment of the diabetes.
Description
Technical field
Medicine of diabetes and preparation method thereof is treated the present invention relates to a kind of, belongs to the field of Chinese medicines.
Background technology
Diabetes are one group of metabolic diseases being characterized with hyperglycaemia.Hyperglycaemia be then due to defect of insulin secretion or
Its biological agent is damaged, or both have concurrently and cause.Long-standing hyperglycaemia during diabetes, cause various tissues, particularly eye,
Kidney, heart, blood vessel, chronic lesion, the dysfunction of nerve.Because western medicine side effect is big, therefore people are to effectively treatment
There is great demand in the Chinese medicine of diabetes, up to now, it has not been found that on relevant report of the invention.
The content of the invention
The present inventor have found effectively treatment glycosuria finally according to the checking repeatedly of research and the clinical test of theory of traditional Chinese medical science
The medicine of disease, so as to complete the present invention.
It is an object of the invention to provide a kind of Chinese medicine composition of effective treatment diabetes.
Another object of the present invention just there is provided the preparation method of the Chinese medicine composition.
Medicine of the present invention is the selection stem of noble dendrobium, the tuber of dwarf lilyturf, radix rehmanniae recen, radix scrophulariae, root of Chinese trichosanthes, Chinese yam, the Radix Astragali, rhizoma atractylodis, the wind-weed, Huang
Cypress, Fructus Corni, the red sage root, prepared rhizome of rehmannia, Ramulus Taxilli, pawpaw, the bighead atractylodes rhizome, myrobalan, keel, the shell of seaear, Semen Cuscutae, fructus alpiniae oxyphyllae, mantis egg-case,
The seed of Oriental arborvitae, gypsum, the root bark of Chinese wolf-berry, rhizoma imperatae, the fruit of Chinese magnoliavine, the root of kudzu vine, the membrane of a chicken's gizzard, root of Chinese trichosanthes are combined preparation, by these medicines
Combination causes that each efficacy of drugs produces synergy such that it is able to effectively treat diabetes.Wherein from the stem of noble dendrobium because its property
Slightly sweet flavor is micro- salty, trembles with fear, and enters to have, lung, kidney channel, there is the beneficial stomach that promotes the production of body fluid, and the function of clearing heat and nourishing yin controls consumption of body fluid caused by febrile disease, and dry is tired to drink, after being ill
Abnormal heat, impairment of yin mesh is dark.From the tuber of dwarf lilyturf because its property sweet and slightly bitter taste, tremble with fear, enter lung, stomach, the heart channel of Hang-Shaoyin, there is a Yin nourishing and lung moistening, relieving restlessness that clears away heart-fire,
The function of reinforcing stomach reg fluid, controls dryness of the lung dry cough, spits blood, spitting of blood, consumptive lung disease, lung carbuncle, consumptive disease dysphoria with smothery sensation, clear thirsty, pyreticosis Tianjin wound, dry throat mouthful
It is dry, constipation.From radix rehmanniae recen because its nature and flavor is sweet, tremble with fear, the thoughts of returning home, liver and kidney channel have a clearing heat and cooling blood, yin-nourishing, the function of promoting the production of body fluid,
Pyreticosis polydipsia is controlled, yin asthenia generating intrinsic heat, hectic fever due to yin labor heat, Heat Diabetes is spitted blood, bleeding from five sense organs or subcutaneous tissue, spot dermexanthesis.From radix scrophulariae because its nature and flavor
It is bitter salty, it is cool, enter lung, kidney channel, there is enriching yin, fall fire, relieving restlessness, the function of removing toxic substances controls pyreticosis polydipsia, sends out spot, and hectic fever due to yin labor heat, night sleeps not
Rather, spontaneous sweating, Tianjin hinder constipation, hematemesis and epistaxis, abscess of throat, carbuncle swells, scrofula.From root of Chinese trichosanthes because its nature and flavor sweetness and bitterness
Acid, it is cool, enter lung, stomach, have and promote the production of body fluid, to quench the thirst, fall fire is moisturized, apocenosis, the function of detumescence, and it is thirsty to control pyreticosis, quenches one's thirst, jaundice, lung
Cough caused by dryness blood, carbuncle swells, hemorrhoid complicated by anal fistula.From Chinese yam because its nature and flavor is sweet, put down, enter lung, spleen, kidney channel, there is invigorating the spleen, tonifying lung is reinforced the kidney, strengthening the essence
Function, control splenasthenic diarrhea, protracted dysentery, cough due to consumptive disease is quenched one's thirst, seminal emission, under band, frequent urination.From the Radix Astragali because its nature and flavor
Sweet, tepor enters lung, the spleen channel, and raw to defend solid table with beneficial, inducing diuresis for removing edema, eliminating toxic, the function of myogenic controls spontaneous perspiration, and night sweat, blood-arthralgia is floated
Swollen, ulcer is not burst or is burst and holds back long；Process with the function of having bowl spares benefit, control internal injury overstrain, splenasthenic diarrhea, prolapse of the anus, deficiency of vital energy blood takes off, and collapses band
And the disease of all laboured breathing deficiency of blood.From rhizoma atractylodis because its nature and flavor is arduous, temperature enters spleen, stomach, there is invigorating the spleen, and eliminating dampness, Xie Yu is warded off
Dirty function, controls wet soreness, and burnout, gastral cavity ruffian abdominal distension, poor appetite is vomitted, diarrhea, dysentery, malaria, phlegm and retained fluid, oedema,
Feel cold, wind-cold-dampness arthralgia, atrophy, yctalopia.From the wind-weed because its is bitter in taste, tremble with fear, enter lung, stomach, kidney channel, there is enriching yin to drop
Fire, the function of moisturize laxation is controlled dysphoria with smothery sensation and is quenched one's thirst, hectic fever due to yin labor heat, cough with lung heat, dry feces, difficult urination.From golden cypress be because
For its is bitter in taste, tremble with fear, enter lung, stomach, kidney channel, there is nourishing Yin and falling fire, the function of moisturize laxation is controlled dysphoria with smothery sensation and quenched one's thirst, hectic fever due to yin labor heat, lung heat
Cough, dry feces, difficult urination.From Fructus Corni because its nature and flavor is sour, tepor enters liver and kidney channel, there is filling liver kidney, puckery essence
Gas, Gu the function of collapse, controls soreness of waist and knee joint, dizziness, tinnitus, impotence, seminal emission, frequent urination, liver cold of insufficiency type heat, incessant sweating due to debility, the heart
Arteries and veins is shaken to dissipate.From the red sage root because its is bitter in taste, tepor enters the heart, Liver Channel, there is a blood circulation and promoting silt, calming heart and tranquilizing mind, apocenosis, analgesic
Function, controls angina pectoris, irregular menstruation, dysmenorrhoea, to close, metrorrhagia under band , Disorder lumps in the abdomen, and accumulation, abdominal pain due to blood stasis, arthralgia, palpitation with fear is not
Sleep, malignant sore swollen drug.From prepared rhizome of rehmannia because its nature and flavor is sweet, tepor enters liver and kidney channel, there is enriching yin, and the function of enriching blood controls the deficiency of Yin
Blood is few, waist knee flaccidity, Cough osteopyrexia, and seminal emission, uterine bleeding, irregular menstruation is quenched one's thirst, number of urinating, deaf, blurred vision.From Ramulus Taxilli be because
It is its nature and flavor bitter sweet, puts down, enter liver and kidney channel, there is a filling liver kidney, strengthening the bones and muscles, except rheumatism, degrading the channel, beneficial blood, antiabortive function controls waist
Knee joint soreness, muscles and bones impotence is weak, hemiplegia, tinea pedis, wind-cold-dampness arthralgia, threatened abortion metrorrhagia, lack of lactation after delivery.From pawpaw because its nature and flavor
Acid, temperature, enter liver, the spleen channel have suppressing the hyperactive liver and easing the stomach, the function of the relaxing muscles and tendons that dries, and control vomiting and diarrhoea convulsion, arthritis with fixed pain caused by dampness, tinea pedis, oedema, dysentery.From
Because its nature and flavor bitter sweet, temperature enters spleen, stomach to the bighead atractylodes rhizome, there is a tonifying spleen, beneficial stomach, eliminating dampness, and in function, control deficient QI of the spleen and stomach, do not think
Diet, the few gas of burnout, empty swollen, diarrhea, phlegm and retained fluid, oedema, jaundice, arthritis with fixed pain caused by dampness, difficult urination is dizzy, and spontaneous perspiration, nausea is uneasy.From
Because its is bitter in taste sour and astringent, temperature enters lung, stomach, large intestine channel to myrobalan, astringes the lung, and puckery intestines, the function of lower gas controls chronic cough aphonia, long
Rush down, protracted dysentery, prolapse of the anus is had blood in stool, uterine bleeding, under band, pass out semen, frequent micturition.From keel because its property sweet-puckery flavor, put down, be included into the heart, liver,
Kidney, large intestine channel, there is tranquillizing the mind by relieving convulsion, and the function of arrest sweating controlling nocturnal emission with astringent drugs, Zhi Jing Epilepsy is demented, and palpitation is forgetful, insomnia and dreamful sleep, spontaneous sweating.Choosing
With the shell of seaear because its nature and flavor is salty, put down, enter liver and kidney channel, there is calming the liver, except heat, the function of improving eyesight controls wind-yang and up-boring, head
Pain dizziness, frightened to jerk, hectic fever due to yin labor heat, optic atrophy.From Semen Cuscutae because its property acrid-sweet flavor, puts down, enter liver and kidney channel, there is tonifying liver
Kidney, benefiting quintessence, the function of improving eyesight controls soreness of waist and knee joint, seminal emission, quenches one's thirst, and dripping urination, mesh is dark.From fructus alpiniae oxyphyllae because its property
Taste is pungent, temperature, enters spleen, kidney channel, there is warm spleen, warms up kidney, and solid and gas, the function of puckery essence controls cold air stomachache, and syncope due to pathogenic cold is vomited and diarrhoea, many salivas, seminal emission,
Dribbling urination, many nights many urine.From mantis egg-case because its nature and flavor is salty, sweet, flat, there is kidney tonifying, the function of controlling nocturnal emission with astringent drugs controls seminal emission, in vain
It is turbid, impotence, premature ejaculation.From the seed of Oriental arborvitae because its nature and flavor is sweet, put down, enter the heart, liver, the spleen channel, have mental-tranquilization, the work(for relaxing bowel
Can, palpitation with fear is controlled, have a sleepless night, seminal emission, night sweat, the function of constipation.From gypsum because its property acrid-sweet flavor, trembles with fear, enter lung, stomach, it is raw
With there is expelling pathogenic factors from muscles for clearing heat, the function that relieving restlessness is quenched the thirst is controlled pyreticosis high fever and is not moved back, and vexed coma, delirious speech is gone mad, and thirsty and dry pharynx, lung heat is breathed heavily
Anxious, heatstroke spontaneous perspiration, stomach headache due to fire-evil, toothache, heat toxin stops up Sheng, and spot dermexanthesis, aphthae forges deposited myogenic sore, ulcer sore is controlled outward
Ulcer, bursts and does not withdraw, the burning hot wound of soup.From the root bark of Chinese wolf-berry because its nature and flavor is sweet, tremble with fear, enter lung, liver and kidney channel, there is heat-clearing, the work(of cool blood
Can, consumptive disease hectic fever night sweat is controlled, lung heat cough and asthma is spitted blood, and bleeding from five sense organs or subcutaneous tissue, blood strangury is quenched one's thirst, hypertension, carbuncle swells, dislikes sore.It is from rhizoma imperatae
Because its nature and flavor is sweet, cold, enter lung, stomach, small intestinl channel, there is cool blood, stop blooding, heat-clearing, the function of diuresis controls pyreticosis polydipsia, spit blood, nosebleed
Blood, lung heat breathes heavily urgency, stomach energy hiccup, gonorrhoea, difficult urination, oedema, jaundice.From the fruit of Chinese magnoliavine because its nature and flavor is sour, temperature enters
Lung, kidney channel, are astringed the lung, and nourshing kidney is promoted the production of body fluid, and receive sweat, and the function of puckery essence is controlled the deficiency syndrome of the lung and breathed with cough, and thirst, spontaneous perspiration, night sweat, internal lesion caused by overexertion is thin
It is thin, emission, protracted dysentery and diarrhea.From the root of kudzu vine because its property acrid-sweet flavor, puts down, enter spleen, stomach, there is rising Yang expelling pathogenic factors from muscles and skin, promoting eruption is stopped
Rush down, the function that relieving restlessness is quenched the thirst controls typhoid fever, warm, headache, Xiang Qiang, dysphoria with smothery sensation disappears and drinks, and diarrhea, dysentery, abnormal pigmentary deposit on the skin examines impermeable, hypertension, the heart
Angina, it is deaf.From the membrane of a chicken's gizzard because its nature and flavor is sweet, put down, enter spleen, stomach, control stagnant, the function of strengthening the spleen and stomach controls dyspepsia
Turgor, vomiting gastric disorder causing nausea, rush down dysentery, infantile malnutrition due to digestive disturbances or intestinalparasites is quenched one's thirst, and is lost and is drowned, larynx numbness acute tonsillitis, noma aphtha.From root of Chinese trichosanthes because its nature and flavor is sweet
Picric acid, it is cool, enter lung, stomach, have and promote the production of body fluid, to quench the thirst, fall fire is moisturized, apocenosis, the function of detumescence, and it is thirsty to control pyreticosis, quenches one's thirst, jaundice,
Dryness of the lung hemoptysis, carbuncle swells, hemorrhoid complicated by anal fistula.
Specific embodiment
The drug dose of instant component is also that inventor summarizes what is drawn by largely groping, and the consumption of each component is following heavy
All there is preferable curative effect in the range of amount：
10-20 grams of the stem of noble dendrobium, 5-15 grams of the tuber of dwarf lilyturf, 15-25 grams of radix rehmanniae recen, 15-25 grams of radix scrophulariae, 10-20 grams of root of Chinese trichosanthes, Chinese yam 25-35
Gram, 25-35 grams of the Radix Astragali, 5-15 grams of rhizoma atractylodis, 5-15 grams of the wind-weed, 5-15 grams of golden cypress, 10-20 grams of Fructus Corni, 10-20 grams of the red sage root is ripe
25-35 grams of glutinous rehmannia, 25-35 grams of Ramulus Taxilli, 5-15 grams of pawpaw, 5-15 grams of the bighead atractylodes rhizome, 5-15 grams of myrobalan, 10-20 grams of keel, the shell of seaear
25-35 grams, 25-35 grams of Semen Cuscutae, 5-15 grams of fructus alpiniae oxyphyllae, 15-25 grams of mantis egg-case, 5-15 grams of the seed of Oriental arborvitae, 15-25 grams of gypsum, ground
10-20 grams of bone skin, 15-25 grams of rhizoma imperatae, 5-15 grams of the fruit of Chinese magnoliavine, 5-15 grams of the root of kudzu vine, 4-8 grams of the membrane of a chicken's gizzard, 10-14 grams of root of Chinese trichosanthes.
Preferably：
15 grams of the stem of noble dendrobium, 10 grams of the tuber of dwarf lilyturf, 20 grams of radix rehmanniae recen, 20 grams of radix scrophulariae, 15 grams of root of Chinese trichosanthes, 30 grams of Chinese yam, 30 grams of the Radix Astragali, rhizoma atractylodis 10
Gram, 10 grams of the wind-weed, 10 grams of golden cypress, 15 grams of Fructus Corni, 15 grams of the red sage root, 30 grams of prepared rhizome of rehmannia, 30 grams of Ramulus Taxilli, 10 grams of pawpaw, the bighead atractylodes rhizome
10 grams, 10 grams of myrobalan, 15 grams of keel, 30 grams of the shell of seaear, 30 grams of Semen Cuscutae, 10 grams of fructus alpiniae oxyphyllae, 20 grams of mantis egg-case, the seed of Oriental arborvitae 10
Gram, 20 grams of gypsum, 15 grams of the root bark of Chinese wolf-berry, 20 grams of rhizoma imperatae, 10 grams of the fruit of Chinese magnoliavine, 10 grams of the root of kudzu vine, 6 grams of the membrane of a chicken's gizzard, 12 grams of root of Chinese trichosanthes.
The preparation method of medicine of the present invention is as follows
First, get the raw materials ready
1st, the stem of noble dendrobium：The dry stem of noble dendrobium is taken, with bubble saturating, vexed profit, removing undesirable root and black branch, segment about to eighty per cant, film is hit, shone
It is dry；
2nd, the tuber of dwarf lilyturf：Net impurity is picked, is soaked in water, pulled out, pump the heart after running through, then cleaned and dry；
3rd, radix rehmanniae recen：Crude drug is taken, impurity is removed, cleaned, slightly moistened, cut sheet, dried, weed out chip；
4th, radix scrophulariae：Net impurity is picked, except removing LU, is cleaned and is run through, cut into slices, dried；
5th, root of Chinese trichosanthes：Impurity is picked, size block is separate, pulled out with bubble about sixty percent thoroughly, vexed profit is uniform to inside and outside humidity, section,
Dry, or wash, pull out, shine to extremely dry, be pounded fritter；
6th, Chinese yam：Net impurity is picked, is soaked in water to Chinese yam central part softening, pulled out and slightly dry in the air, section is dried or dried；
7th, the Radix Astragali：Net impurity is picked, the root head and hollow larger root of residual is removed, is soaked in water, pulled out, cut in time after running through
Piece, dries；
8th, rhizoma atractylodis：Impurity is picked, with bubble to seven, eighty per cant thoroughly, is pulled out, cut into slices after running through, dried；
9th, the wind-weed：Net impurity is picked, is hit with water and washed, pulled out, softened, section is dried；
10th, golden cypress：Impurity is picked, is washed, pulled out, run through, cut into slices or chopping, dried；
11st, Fructus Corni：Clean, except removal core and impurity, dry；
12nd, the red sage root：Net impurity is picked, rhizome is removed, cleaned, pulled out, cut into slices after running through, dried；
13rd, prepared rhizome of rehmannia：Take prepared rhizome of rehmannia and put and forge in pot, filling eighty per cant expires, cover one pot above, two pots of joint yellow mud sealing, on
Ballast, the aobvious coke yellow degree of being of the blank sheet of paper being attached on the lid the bottom of a pan is calcined to mild and heavy respiration, blocks vent, after cooling, is taken out；Or will be ripe
Glutinous rehmannia to be put in pot and directly fry charcoal and also may be used；
14th, Ramulus Taxilli：Wash, run through, segment is dried；
15th, pawpaw：Clear water is cleaned, and is slightly soaked, and vexed profit is put in food steamer and cooked to saturating, is cut into slices while hot, weather exposure, with by red turn
Untill atropurpureus；
16th, the bighead atractylodes rhizome：Net impurity is picked, is soaked in water, pulled out after bubble, run through, cut into slices, dried；
17th, myrobalan：Crude drug is taken, impurity, cleaning, drying is removed；
18th, keel：Outwash soil, smashes；
19th, the shell of seaear：Clean and dry, knock fragment；
20th, Semen Cuscutae：Cross square-bottomed bamboo basket and remove impurity, clean, dry；
21st, fructus alpiniae oxyphyllae：Take fructus alpiniae oxyphyllae to put in pot, fry burned black to shell, take out cold, remove shell, take benevolence and smash use to pieces；
22nd, mantis egg-case：By net mantis egg-case and wheat bran with frying to strong yellow, take out, weed out wheat bran, cool；
23rd, the seed of Oriental arborvitae：Net impurity is picked, the shell of residual is removed and is planted skin；
24th, gypsum：Miscellaneous stone is removed, soil is cleaned, fritter is broken into；
25th, the root bark of Chinese wolf-berry：Impurity and core are picked, is slightly washed, segment is dried；
26th, rhizoma imperatae：Net impurity is picked, is cleaned, micro- profit, segment is dried, net chip of winnowing with a dustpan；
27th, the fruit of Chinese magnoliavine：Grey bits are weeded out, impurity is removed, is put and steamed in food steamer saturating, taking-up is dried；
28th, the root of kudzu vine：Impurity is picked, is cleaned, be soaked in water, pulled out, run through, section, dries in time；
29th, the membrane of a chicken's gizzard：Impurity is picked, is rinsed and is dried；
30th, root of Chinese trichosanthes：Impurity is picked, size block is separate, pulled out with bubble about sixty percent thoroughly, vexed profit is uniform to inside and outside humidity, cuts
Piece, dries, or washes, and pulls out, shines to extremely dry, is pounded fritter.
2nd, prepare
1st, by the stem of noble dendrobium of the weight, the tuber of dwarf lilyturf, radix rehmanniae recen, radix scrophulariae, root of Chinese trichosanthes, Chinese yam, the Radix Astragali, rhizoma atractylodis, the wind-weed, golden cypress, mountain Zhu
Cornel, the red sage root, prepared rhizome of rehmannia, Ramulus Taxilli, pawpaw, the bighead atractylodes rhizome, myrobalan, keel, the shell of seaear, Semen Cuscutae, fructus alpiniae oxyphyllae, mantis egg-case, the seed of Oriental arborvitae,
Gypsum, the root bark of Chinese wolf-berry, rhizoma imperatae, the fruit of Chinese magnoliavine, the root of kudzu vine, the membrane of a chicken's gizzard, root of Chinese trichosanthes are put into decocting container, are added water 8 times and are measured, immersion 100
After minute, fry by intense fire to boil and rise, then with being cooked by slow fire 20 minutes, filter to obtain first time decoction liquor, first time decoction liquor is poured into
In container；
2nd, the dregs of a decoction of filtering are added water 6 times and is measured, boiled by intense fire, then with being cooked by slow fire 20 minutes, filter to obtain second decoction liquor；
3rd, will decoction liquor mixing and stirring twice, be divided into 4 doses and take.
There is a Yin nourishing and lung moistening tuber of dwarf lilyturf in prescription, relieving restlessness that clears away heart-fire, and the function of reinforcing stomach reg fluid is monarch drug in a prescription；Radix rehmanniae recen has clearing heat and cooling blood,
Yin-nourishing, the function of promoting the production of body fluid；Radix scrophulariae has an enriching yin, fall fire, relieving restlessness, the function of removing toxic substances, and the two is ministerial drug, and three taste medicines play yin-nourishing jointly
Moistening lung, relieving restlessness that clears away heart-fire, reinforcing stomach reg fluid, clearing heat and cooling blood, the effect of nourishing Yin and falling fire, treatment diabetes effect comprehensively, and is moistened with yin-nourishing
Lung, reinforcing stomach reg fluid can effect a permanent cure based on clearing heat and cooling blood, and the bighead atractylodes rhizome has a tonifying spleen, beneficial stomach, eliminating dampness, and in function be adjutant, the shell of seaear has
Calming the liver, except heat, to make medicine, all medicines are to take stopgap measures to the function of improving eyesight with being left.
Medicine of the present invention has Yin nourishing and lung moistening, relieving restlessness that clears away heart-fire, reinforcing stomach reg fluid, clearing heat and cooling blood, nourishing Yin and falling fire, except hot improving eyesight
Function, for treating diabetes, short treating period, instant effect, non-relapse after healing.
The beneficial effect of medicine of the present invention is expanded on further below by way of test example, these test examples include this hair
The animal toxicity test report of bright medicine and clinical observation on the therapeutic effect data.
The animal toxicity test report of [test example 1] medicine of the present invention：
Rabbit 30 is taken, male and female dual-purpose, 2.0-2.5kg of body weight is divided to two groups, and every group 15, one of which is tested for overdose
Group, another group is normal amount test group.Super quantity group is 20ml/kg, and normal amount is 10ml/kg, and administering mode is given for administration by gavage
Medicine, twice daily, takes medicine continuously 7 days, the reaction of observation administration daily, as a result shows that two groups of rabbit activities, diet are normal, and medicine is without bad
Toxic and side effect.
The clinical observation on the therapeutic effect of [test example 2] medicine of the present invention
1st, physical data
Accept type i diabetes out-patient totally 49 for medical treatment.
2nd, diagnostic criteria
Fasting blood-glucose is more than 7.0 mM/ls, and two hours blood glucoses are more than or equal to 11.1 mM/ls after the meal；
Type 1 diabetes：Age of onset is light, 30-45 Sui, and suddenly, food more than drink diuresis becomes thin symptom substantially to onset more, blood sugar level
Height, patient is with DKA as onset symptoms, and serum insulin and C peptide levels are low, and ICA, IAA or GAD antibody can be in sun
Property.
3rd, treatment method
From above-mentioned medicament, taken to patient, each take 1 dose, early daily, evening respectively takes 1 time, be within 20 days a course for the treatment of, continuously
Take 3 courses for the treatment of.
4th, efficacy assessment standard
It is effective：Diabetic symptom disappears, and blood sugar recovery is normal, recovery from illness；
Take a turn for the better：Diabetic symptom is clearly better, and blood sugar progressively recovers normal；
It is invalid：Improvement standard person is not reached.
5th, treatment results（See the table below）
In above-mentioned treatment, with drug treatment of diabetic patient of the present invention 49, as a result effective 40, obvious effective rate is 81.6%, good
Turn 7, improvement rate is 14.3%, and invalid 2, total effective rate is 95.9%.
Claims (3)
1. a kind of medicine for treating diabetes, it is characterised in that：It is made up of the bulk drug in following weight range：
10-20 grams of the stem of noble dendrobium, 5-15 grams of the tuber of dwarf lilyturf, 15-25 grams of radix rehmanniae recen, 15-25 grams of radix scrophulariae, 10-20 grams of root of Chinese trichosanthes, Chinese yam 25-35
Gram, 25-35 grams of the Radix Astragali, 5-15 grams of rhizoma atractylodis, 5-15 grams of the wind-weed, 5-15 grams of golden cypress, 10-20 grams of Fructus Corni, 10-20 grams of the red sage root is ripe
25-35 grams of glutinous rehmannia, 25-35 grams of Ramulus Taxilli, 5-15 grams of pawpaw, 5-15 grams of the bighead atractylodes rhizome, 5-15 grams of myrobalan, 10-20 grams of keel, the shell of seaear
25-35 grams, 25-35 grams of Semen Cuscutae, 5-15 grams of fructus alpiniae oxyphyllae, 15-25 grams of mantis egg-case, 5-15 grams of the seed of Oriental arborvitae, 15-25 grams of gypsum, ground
10-20 grams of bone skin, 15-25 grams of rhizoma imperatae, 5-15 grams of the fruit of Chinese magnoliavine, 5-15 grams of the root of kudzu vine, 4-8 grams of the membrane of a chicken's gizzard, 10-14 grams of root of Chinese trichosanthes.
2. medicine according to claim 1, wherein the consumption of each bulk drug is：
15 grams of the stem of noble dendrobium, 10 grams of the tuber of dwarf lilyturf, 20 grams of radix rehmanniae recen, 20 grams of radix scrophulariae, 15 grams of root of Chinese trichosanthes, 30 grams of Chinese yam, 30 grams of the Radix Astragali, rhizoma atractylodis 10
Gram, 10 grams of the wind-weed, 10 grams of golden cypress, 15 grams of Fructus Corni, 15 grams of the red sage root, 30 grams of prepared rhizome of rehmannia, 30 grams of Ramulus Taxilli, 10 grams of pawpaw, the bighead atractylodes rhizome
10 grams, 10 grams of myrobalan, 15 grams of keel, 30 grams of the shell of seaear, 30 grams of Semen Cuscutae, 10 grams of fructus alpiniae oxyphyllae, 20 grams of mantis egg-case, the seed of Oriental arborvitae 10
Gram, 20 grams of gypsum, 15 grams of the root bark of Chinese wolf-berry, 20 grams of rhizoma imperatae, 10 grams of the fruit of Chinese magnoliavine, 10 grams of the root of kudzu vine, 6 grams of the membrane of a chicken's gizzard, 12 grams of root of Chinese trichosanthes.
3. the preparation method of medicine according to claim 1 or claim 2, it comprises the following steps：
（One）Get the raw materials ready
（1）The stem of noble dendrobium：The dry stem of noble dendrobium is taken, with bubble saturating, vexed profit, removing undesirable root and black branch, segment about to eighty per cant, film is hit,
Dry；
（2）The tuber of dwarf lilyturf：Net impurity is picked, is soaked in water, pulled out, pump the heart after running through, then cleaned and dry；
（3）Radix rehmanniae recen：Crude drug is taken, impurity is removed, cleaned, slightly moistened, cut sheet, dried, weed out chip；
（4）Radix scrophulariae：Net impurity is picked, except removing LU, is cleaned and is run through, cut into slices, dried；
（5）Root of Chinese trichosanthes：Impurity is picked, size block is separate, pulled out with bubble about sixty percent thoroughly, vexed profit is uniform to inside and outside humidity, cuts
Piece, dries, or washes, and pulls out, shines to extremely dry, is pounded fritter；
（6）Chinese yam：Net impurity is picked, is soaked in water to Chinese yam central part softening, pulled out and slightly dry in the air, section is dried or dried；
（7）The Radix Astragali：Net impurity is picked, the root head and hollow larger root of residual is removed, is soaked in water, pulled out, cut in time after running through
Piece, dries；
（8）Rhizoma atractylodis：Impurity is picked, with bubble to seven, eighty per cant thoroughly, is pulled out, cut into slices after running through, dried；
（9）The wind-weed：Net impurity is picked, is hit with water and washed, pulled out, softened, section is dried；
（10）Golden cypress：Impurity is picked, is washed, pulled out, run through, cut into slices or chopping, dried；
（11）Fructus Corni：Clean, except removal core and impurity, dry；
（12）The red sage root：Net impurity is picked, rhizome is removed, cleaned, pulled out, cut into slices after running through, dried；
（13）Prepared rhizome of rehmannia：Take prepared rhizome of rehmannia and put and forge in pot, filling eighty per cant expires, cover one pot above, two pots of joint yellow mud sealing, on
Ballast, the aobvious coke yellow degree of being of the blank sheet of paper being attached on the lid the bottom of a pan is calcined to mild and heavy respiration, blocks vent, after cooling, is taken out；Or will be ripe
Glutinous rehmannia to be put in pot and directly fry charcoal and also may be used；
（14）Ramulus Taxilli：Wash, run through, segment is dried；
（15）Pawpaw：Clear water is cleaned, and is slightly soaked, and vexed profit is put in food steamer and cooked to saturating, is cut into slices while hot, weather exposure, with by red turn
Untill atropurpureus；
（16）The bighead atractylodes rhizome：Net impurity is picked, is soaked in water, pulled out after bubble, run through, cut into slices, dried；
（17）Myrobalan：Crude drug is taken, impurity, cleaning, drying is removed；
（18）Keel：Outwash soil, smashes；
（19）The shell of seaear：Clean and dry, knock fragment；
（20）Semen Cuscutae：Cross square-bottomed bamboo basket and remove impurity, clean, dry；
（21）Fructus alpiniae oxyphyllae：Take fructus alpiniae oxyphyllae to put in pot, fry burned black to shell, take out cold, remove shell, take benevolence and smash use to pieces；
（22）Mantis egg-case：By net mantis egg-case and wheat bran with frying to strong yellow, take out, weed out wheat bran, cool；
（23）The seed of Oriental arborvitae：Net impurity is picked, the shell of residual is removed and is planted skin；
（24）Gypsum：Miscellaneous stone is removed, soil is cleaned, fritter is broken into；
（25）The root bark of Chinese wolf-berry：Impurity and core are picked, is slightly washed, segment is dried；
（26）Rhizoma imperatae：Net impurity is picked, is cleaned, micro- profit, segment is dried, net chip of winnowing with a dustpan；
（27）The fruit of Chinese magnoliavine：Grey bits are weeded out, impurity is removed, is put and steamed in food steamer saturating, taking-up is dried；
（28）The root of kudzu vine：Impurity is picked, is cleaned, be soaked in water, pulled out, run through, section, dries in time；
（29）The membrane of a chicken's gizzard：Impurity is picked, is rinsed and is dried；
（30）Root of Chinese trichosanthes：Impurity is picked, size block is separate, pulled out with bubble about sixty percent thoroughly, vexed profit is uniform to inside and outside humidity, cuts
Piece, dries, or washes, and pulls out, shines to extremely dry, is pounded fritter；
（Two）Prepare
（1）By the stem of noble dendrobium of the weight, the tuber of dwarf lilyturf, radix rehmanniae recen, radix scrophulariae, root of Chinese trichosanthes, Chinese yam, the Radix Astragali, rhizoma atractylodis, the wind-weed, golden cypress, mountain Zhu
Cornel, the red sage root, prepared rhizome of rehmannia, Ramulus Taxilli, pawpaw, the bighead atractylodes rhizome, myrobalan, keel, the shell of seaear, Semen Cuscutae, fructus alpiniae oxyphyllae, mantis egg-case, the seed of Oriental arborvitae,
Gypsum, the root bark of Chinese wolf-berry, rhizoma imperatae, the fruit of Chinese magnoliavine, the root of kudzu vine, the membrane of a chicken's gizzard, root of Chinese trichosanthes are put into decocting container, are added water 8 times and are measured, immersion 100
After minute, fry by intense fire to boil and rise, then with being cooked by slow fire 20 minutes, filter to obtain first time decoction liquor, first time decoction liquor is poured into
In container；
（2）The dregs of a decoction of filtering are added water 6 times and is measured, boiled by intense fire, then with being cooked by slow fire 20 minutes, filter to obtain second decoction liquor；
（3）Decoction liquor mixing and stirring twice is incited somebody to action, is divided into 4 doses and is taken.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108114201A (en) * | 2018-02-01 | 2018-06-05 | 重庆跃龙生物制药有限公司 | Chinese medicine composition for treating diabetes and its preparation method and application |
| CN108743829A (en) * | 2018-07-31 | 2018-11-06 | 李少伦 | A kind of drug and preparation method thereof for treating pure hyperglycemia |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103432420A (en) * | 2013-04-19 | 2013-12-11 | 陕西步长制药有限公司 | Traditional Chinese medicine composition for treating diabetes, and preparation method and detection method thereof |
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2017
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103432420A (en) * | 2013-04-19 | 2013-12-11 | 陕西步长制药有限公司 | Traditional Chinese medicine composition for treating diabetes, and preparation method and detection method thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108114201A (en) * | 2018-02-01 | 2018-06-05 | 重庆跃龙生物制药有限公司 | Chinese medicine composition for treating diabetes and its preparation method and application |
| CN108743829A (en) * | 2018-07-31 | 2018-11-06 | 李少伦 | A kind of drug and preparation method thereof for treating pure hyperglycemia |
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Application publication date: 20170524 |