CN108671076A - A kind of drug and preparation method thereof for treating alpastic anemia - Google Patents

A kind of drug and preparation method thereof for treating alpastic anemia Download PDF

Info

Publication number
CN108671076A
CN108671076A CN201810855764.7A CN201810855764A CN108671076A CN 108671076 A CN108671076 A CN 108671076A CN 201810855764 A CN201810855764 A CN 201810855764A CN 108671076 A CN108671076 A CN 108671076A
Authority
CN
China
Prior art keywords
grams
impurity
dry
drug
fruit
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
CN201810855764.7A
Other languages
Chinese (zh)
Inventor
李少伦
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CN201810855764.7A priority Critical patent/CN108671076A/en
Publication of CN108671076A publication Critical patent/CN108671076A/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284—Atractylodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/074—Ganoderma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/076—Poria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258—Panax (ginseng)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/39—Convolvulaceae (Morning-glory family), e.g. bindweed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/40—Cornaceae (Dogwood family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/43—Cuscutaceae (Dodder family), e.g. Cuscuta epithymum or greater dodder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481—Astragalus (milkvetch)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/487—Psoralea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
    • A61K36/605—Morus (mulberry)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/64—Orobanchaceae (Broom-rape family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/69—Polygalaceae (Milkwort family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/704—Polygonum, e.g. knotweed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
    • A61K36/725—Ziziphus, e.g. jujube
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/80—Scrophulariaceae (Figwort family)
    • A61K36/804—Rehmannia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A61K36/815—Lycium (desert-thorn)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps

Abstract

The invention discloses a kind of drugs and preparation method thereof for treating alpastic anemia, it is mainly prepared by Rhizoma Atractylodis Macrocephalae, ginseng, Radix Astragali, fushen, Radix Polygalae, spina date seed, Semen Cuscutae, the fruit of Chinese wolfberry, prepared rehmannia root, the fleece-flower root, Fructus Corni, mulberries, ganoderma lucidum according to a certain weight ratio, drug of the present invention has the function of tonifying spleen benefit stomach, prevent prolapse and engender liquid, antitoxic heart-soothing and sedative, tonifying middle-Jiao and Qi, nourishing yin and supplementing blood, liver-kidney tonifying, alpastic anemia is quick, good effect for treating, and does not recur.

Description

A kind of drug and preparation method thereof for treating alpastic anemia
Technical field
The present invention relates to a kind of drugs and preparation method thereof for treating alpastic anemia, belong to the field of Chinese medicines.
Technical background
Alpastic anemia is one group of marrow hematopoiesis function failure syndrome caused by Different types of etiopathogenises, is made with marrow Haemocyte hypoplasia and peripheral blood whole blood trace elements are characterized.Chinese medicine then think alpastic anemia and acute pulmonary tuberculosis marrow it is withered, Spleen kidney deficiency is weak, liver kidney deficiency is weak, qi-blood deficiency related.Since western medicine side effect is big, people are to effectively treating regeneration barrier There are great demands for the Chinese medicine of impenetrability anaemia, up to now, it has not been found that the related report about the present invention.
Invention content
The present inventor is on the basis of hospital handed down from one's ancestors, and the verification repeatedly Jing Guo clinical test, has finally found and effectively controls The drug of alpastic anemia is treated, so as to complete the present invention.
It is an object of the invention to provide a kind of Chinese medicine compositions of effective treatment alpastic anemia.
Another aim of the present invention is to provide the preparation methods of the Chinese medicine composition.
The present invention is selection Rhizoma Atractylodis Macrocephalae, ginseng, Radix Astragali, fushen, Radix Polygalae, spina date seed, Semen Cuscutae, the fruit of Chinese wolfberry, prepared rehmannia root, He Shou Crow, Fructus Corni, mulberries, ganoderma lucidum, psoralea corylifolia, Herba Cistanches drug are combined preparation, these pharmaceutical compositions are made each drug Effect generates synergistic effect, so as to effectively treat alpastic anemia.Wherein, it is because its is bitter in taste to select Rhizoma Atractylodis Macrocephalae Sweet, warm enters spleen, stomach, there is a tonifying spleen, beneficial stomach, eliminating dampness, and in function, control deficient QI of the spleen and stomach, do not feel like eating, burnout lacks gas, empty Swollen, diarrhea, phlegm and retained fluid, oedema, jaundice, arthritis with fixed pain caused by dampness, difficult urination is dizzy, spontaneous perspiration, and nausea is uneasy.It is because of its nature and flavor to select ginseng Sweet micro- sweet, warm, enters spleen, lung channel, reinforces vital energy, prevent prolapse and engender liquid, the function of tranquilizing the mind, and it is deficient to control internal lesion caused by overexertion, deficiency of food, burnout, gastric disorder causing nausea Spit food, lingering diarrhea of defecating, cough of deficient and syndrome characterized by dyspnea, spontaneous perspiration sudden collapse, palpitation with fear, forgetful, dizziness and headache, impotence, frequent micturition quenches one's thirst, and woman uterine bleeding is small Youngster shies slowly and perennial and irrecoverable weakness, the disease of all qi-blood-body fluid deficiencies.It is because its nature and flavor is sweet to select Radix Astragali, and tepor enters lung, the spleen channel, Raw inducing diuresis for removing edema, eliminating toxic, the function of myogenic controls spontaneous perspiration, night sweat, blood-arthralgia, edema with there is an invigorating qi for consolidating superficies, un-festering of ulcer or bursts long It holds back；The toast function of having tonifying middle-Jiao and Qi controls internal injury overstrain, and splenasthenic diarrhea, rectal prolapse, deficiency of vital energy blood is de-, collapses band and all laboured breathing deficiency of blood Disease.It is to put down because of its property slightly sweet flavor, enter the heart, the spleen channel, there is calming heart to select fushen, is calmed the nerves, and the function of Li Shui controls palpitation with fear of having a guilty conscience, It is forgetful, , Jing Epilepsy of having a sleepless night, difficult urination.It is to enter the heart, kidney channel because its is bitter in taste acrid in flavour and warm in nature, there is tranquilize the mind and promote the intelligence, dispel to select Radix Polygalae Phlegm, the function of Xie Yu control palpitation with fear, forgetful, nocturnal emission, insomnia, cough ant phlegm, ulcer sore swells.It is because of its nature and flavor to select spina date seed Sweet and neutral enters the heart, spleen, liver, gallbladder channel, has nourishing the liver, calming heart to calm the nerves, and the function of arrest sweating controls restlessness of asrhenia type and insomnia, palpitation of palpitating with fear, and polydipsia is empty Sweat.It is to enter liver and kidney channel because of the pungent sweet and neutral of its nature and flavor, have filling liver kidney, benefiting quintessence, the function of improving eyesight to control waist and knee to select Semen Cuscutae Ache, seminal emission is quenched one's thirst, dripping urination, and mesh is dark.It is to have a nourshing kidney because of its nature and flavor sweet and neutral to select the fruit of Chinese wolfberry, moistening lung, and tonifying liver is bright Purpose function controls liver-kidney Yin deficiency, and soreness and weakness of waist and knees is had a dizzy spell, and the more tears of blurred vision, cough due to consumptive disease is quenched one's thirst, and loses clear.Select prepared rehmannia root It is because its nature and flavor is sweet, tepor enters liver and kidney channel, there is enriching yin, the function of enriching blood, and it is few to control deficiency of Yin blood, waist knee flaccidity, Cough osteopyrexia, Seminal emission, uterine bleeding, irregular menstruation are quenched one's thirst, number of urinating, deaf, blurred vision.It is because its nature and flavor bitter sweet is puckery to select the fleece-flower root, and tepor enters Liver and kidney channel, there is a tonifying liver, kidney-nourishing, blood-nourishing, the function of wind-dispelling, controls liver-kidney Yin deficiency, and hair must be early white, and the deficiency of blood is dizzy, and waist and knee is weak, muscle Bone is ached, and band, chronic malaria, protracted dysentery, chronic hepatitis, carbuncle swells, scrofula, intestines wind, haemorrhoids are collapsed in seminal emission.It is because of its property to select Fructus Corni Sour, tepor enters liver and kidney channel, there is filling liver kidney, puckery vital essence, admittedly the function of collapsing, controls soreness of waist and knee joint, dizziness, tinnitus, impotence, something lost Essence, frequent urination, liver cold of insufficiency type heat, incessant sweating due to debility, the heart shake arteries and veins and dissipate.It is to tremble with fear because its nature and flavor is sweet, enter liver, kidney channel has to select mulberries Tonifying liver, kidney-nourishing relieve dizziness, high fever, infantile convulsions, epilepsy, etc., and grow the function of liquid, control liver-kidney Yin deficiency, quench one's thirst, and constipation, mesh is dark, tinnitus, scrofula, articular instability.Select spirit Sesame is because of its nature and flavor sweet and neutral, and the thoughts of returning home, lung, liver and kidney channel have invigorating qi for tranquilization, relieving cough and asthma function to control dizziness egersis, palpitaition Shortness of breath, consumptive disease cough and asthma.It is to enter kidney channel because its nature and flavor is acrid in flavour and warm in nature, there is the function of tonifying the kidney and support yang, control that kidney deficiency is cold to rush down to select psoralea corylifolia, The enuresis, involuntary emission, frequent urination, impotence, waist and knee crymodynia, cold of insufficiency type asthma are coughed, external application curing vitiligo.It is because of its nature and flavor to select Herba Cistanches Sweet acid is salty, temperature, enters kidney, large intestine channel, has kidney tonifying, strengthening the essence to moisturize, and the function of gut purge controls impotence in male, female sterility, under band, blood It collapses, waist and knee crymodynia, blood depletion constipation.
The drug dose of instant component is also to be obtained by plenty of explorations of the inventor, and the dosage of each component is under It states all to have in weight range and have a better effect：
10-20 grams of Rhizoma Atractylodis Macrocephalae, 5-9 grams of ginseng, 25-35 grams of Radix Astragali, 7-12 grams of fushen, 5-15 grams of Radix Polygalae, 5-15 grams of spina date seed, Tu Sub- 15-25 grams, 10-20 grams of the fruit of Chinese wolfberry, 15-25 grams of prepared rehmannia root, 10-20 grams of the fleece-flower root, 5-15 grams of Fructus Corni, 35-45 grams of mulberries, 7-12 grams of ganoderma lucidum, 10-20 grams of psoralea corylifolia, 10-15 grams of Herba Cistanches.
Preferably
15 grams of Rhizoma Atractylodis Macrocephalae, 7 grams of ginseng, 30 grams of Radix Astragali, 9 grams of fushen, 10 grams of Radix Polygalae, 10 grams of spina date seed, 20 grams of Semen Cuscutae, the fruit of Chinese wolfberry 15 Gram, 20 grams of prepared rehmannia root, 15 grams of the fleece-flower root, 10 grams of Fructus Corni, 40 grams of mulberries, 9 grams of ganoderma lucidum, 15 grams of psoralea corylifolia, 12 grams of Herba Cistanches.
The preparation method of drug of the present invention is as follows
One, it stocks up
1, Rhizoma Atractylodis Macrocephalae：Net impurity is picked, is soaked in water, is pulled out after bubble, is moisturized, is sliced, dries；
2, ginseng：Except removing LU, segment；
3, Radix Astragali：Net impurity is picked, remaining head and hollow larger root is removed, is soaked in water, pulls out, cut in time after moisturizing Piece dries；
4, fushen：Crude drug is taken, impurity is removed, cleans, moisturizes, the sheet or block of square is cut into, dries in the shade；
5, Radix Polygalae：Impurity is picked, segment weeds out grey bits；
6, spina date seed：Active compound is put into bamboo basket, sinks in clear water cylinder, benevolence is made to keep afloat, and jujube kernel is pulled out, shone by the heavy bottom of shell It is dry；
7, Semen Cuscutae：It crosses square-bottomed bamboo basket and removes impurity, clean, dry；
8, the fruit of Chinese wolfberry：It winnows with a dustpan net impurity, plucks remaining stalk and the base of a fruit；
9, prepared rehmannia root：Take crude drug, steam to surface corvinus, take out, shine to eighty per cant it is dry when, be sliced, it is dry；
10, the fleece-flower root：Impurity is picked, is cleaned, thoroughly with bubble to eighty per cant, is pulled out, is moistened to uniform humidity inside and outside, be sliced or the side of being cut into Block dries；
11, Fructus Corni：It cleans, removes removal core and impurity, dry；
12, mulberries：It is eluted with water, picks impurity, extract long handle, dry；
13, ganoderma lucidum：Impurity is removed, is cleaned, is softened, cut sheet, it is dry, weed out clast；
14, psoralea corylifolia：It winnows with a dustpan net impurity, cleans, dry；
15, Herba Cistanches：Net impurity is picked, clear water impregnates, changes water daily 1-2 times, be such as salty desert cistanche, steeps salinity to the greatest extent, moisturizes, longitudinal Slice, is dried.
Two, it prepares
1, by the Rhizoma Atractylodis Macrocephalae of the weight, ginseng, Radix Astragali, fushen, Radix Polygalae, spina date seed, Semen Cuscutae, the fruit of Chinese wolfberry, prepared rehmannia root, He Shou Crow, Fructus Corni, mulberries, ganoderma lucidum, psoralea corylifolia, Herba Cistanches are put into decocting container, add 6 times of amounts of water, after impregnating 100 minutes, intense fire Boiling is decocted, then with being cooked by slow fire 20 minutes, filters to obtain first time decoction liquor, first time decoction liquor is poured into container；
2, the dregs of a decoction of filtering are added into 4 times of amounts of water, boiled by intense fire, then with being cooked by slow fire 20 minutes, filter to obtain second of decoction liquor；
3, it decoction liquor will be mixed evenly twice, and be divided into 3 doses and take.
Rhizoma Atractylodis Macrocephalae tonifying spleen in prescription, beneficial stomach, eliminating dampness, and in, ginseng reinforces vital energy, prevent prolapse and engender liquid, both functions of tranquilizing the mind For monarch drug in a prescription；Radix Astragali invigorating qi for consolidating superficies, inducing diuresis for removing edema, eliminating toxic, myogenic, tonifying middle-Jiao and Qi, fushen have calming heart, calm the nerves, the function of Li Shui, with Radix Polygalae, spina date seed be ministerial drug, Six-element medicine play jointly tonifying spleen benefit stomach, reinforce vital energy, prevent prolapse and engender liquid, antitoxic heart-soothing and sedative, tonifying middle-Jiao and Qi, The effect of Li Shui, treatment alpastic anemia effect is comprehensive, and with tonifying spleen benefit stomach, prevent prolapse and engender liquid, antitoxic heart-soothing and sedative, tonifying middle-Jiao and Qi Based on, it can effect a permanent cure；It is adjutant that prepared rehmannia root, which has the function of nourishing yin and supplementing blood and the fruit of Chinese wolfberry, Semen Cuscutae, the fleece-flower root, Fructus Corni,；Mulberries have Tonifying liver, kidney-nourishing relieve dizziness, high fever, infantile convulsions, epilepsy, etc., and the function and remaining all medicines for growing liquid are to make medicine, are to take stopgap measures.
Drug of the present invention has tonifying spleen benefit stomach, prevent prolapse and engender liquid, antitoxic heart-soothing and sedative, tonifying middle-Jiao and Qi, nourishing yin and supplementing blood, liver-kidney tonifying Function, for treating alpastic anemia, short treating period, quick, non-relapse after healing.
Specific implementation mode
Carry out the advantageous effect of the present invention is further explained the drug below by way of test example, these test examples include this hair The animal toxicity test report of bright drug and clinical observation on the therapeutic effect data.
The animal toxicity test of [test example 1] drug of the present invention is reported：
Rabbit 30, male and female dual-purpose, 2.0-2.5kg of weight is taken to be divided to two groups, every group 15, one of which is tested for overdose Group, another group is normal amount test group.Super quantity group is 20ml/kg, normal amount 10ml/kg, and administering mode gives for administration by gavage Medicine even served 7 days twice daily, the reaction of observation administration daily, the results showed that two groups of rabbit activities, diet are normal, and drug is without bad Toxic side effect.
The clinical observation on the therapeutic effect of [test example 2] drug of the present invention
1, general information
Accept alpastic anemia out-patient totally 43 for medical treatment.
2, diagnostic criteria
Classical symptom is：Anaemia, skin and mucosa and visceral hemorrhage, respiratory tract, alimentary canal, urogenital tract and mucocutaneous sense Dye.
3, therapy
Above-mentioned medicament is selected, is taken to patient, each taking 1 dose, early daily, evening respectively takes 1 time, 30 days as a treatment course, continuously It takes 3 course for the treatment of.
4, efficacy assessment standard
It is effective：Aplastic anemia shape disappears, and constitution restores normal, and follow-up 1 year is without recurrence；
It improves：Anemia, skin and mucosa and visceral hemorrhage, respiratory tract, alimentary canal, urogenital tract and mucocutaneous infections. The phenomenon that mitigate, aplastic anemia shape is clearly better, and constitution gradually restores normal；
In vain：Improvement standard person is not achieved.
5, treatment results（It see the table below）
In above-mentioned treatment, with drug therapy Patients with Aplastic Anemia 43 of the present invention, as a result effective 36, obvious effective rate is 83.72%, it improves 4, improvement rate 9.31%, invalid 3, total effective rate 93.03%.

Claims (3)

1. a kind of drug for treating alpastic anemia, it is characterised in that：It is by the bulk pharmaceutical chemicals system in following weight range At：
10-20 grams of Rhizoma Atractylodis Macrocephalae, 5-9 grams of ginseng, 25-35 grams of Radix Astragali, 7-12 grams of fushen, 5-15 grams of Radix Polygalae, 5-15 grams of spina date seed, Tu Sub- 15-25 grams, 10-20 grams of the fruit of Chinese wolfberry, 15-25 grams of prepared rehmannia root, 10-20 grams of the fleece-flower root, 5-15 grams of Fructus Corni, 35-45 grams of mulberries, 7-12 grams of ganoderma lucidum, 10-20 grams of psoralea corylifolia, 10-15 grams of Herba Cistanches.
2. drug according to claim 1, wherein the dosage of each bulk pharmaceutical chemicals is：
15 grams of Rhizoma Atractylodis Macrocephalae, 7 grams of ginseng, 30 grams of Radix Astragali, 9 grams of fushen, 10 grams of Radix Polygalae, 10 grams of spina date seed, 20 grams of Semen Cuscutae, the fruit of Chinese wolfberry 15 Gram, 20 grams of prepared rehmannia root, 15 grams of the fleece-flower root, 10 grams of Fructus Corni, 40 grams of mulberries, 9 grams of ganoderma lucidum, 15 grams of psoralea corylifolia, 12 grams of Herba Cistanches.
3. the preparation method of drug according to claim 1 or claim 2, it includes the following steps：
（One）Stock
（1）Rhizoma Atractylodis Macrocephalae：Net impurity is picked, is soaked in water, is pulled out after bubble, is moisturized, is sliced, dries；
（2）Ginseng：Except removing LU, segment；
（3）Radix Astragali：Net impurity is picked, remaining head and hollow larger root is removed, is soaked in water, pulls out, cut in time after moisturizing Piece dries；
（4）Fushen：Crude drug is taken, impurity is removed, cleans, moisturizes, the sheet or block of square is cut into, dries in the shade；
（5）Radix Polygalae：Impurity is picked, segment weeds out grey bits；
（6）Spina date seed：Active compound is put into bamboo basket, sinks in clear water cylinder, benevolence is made to keep afloat, and jujube kernel is pulled out, shone by the heavy bottom of shell It is dry；
（7）Semen Cuscutae：It crosses square-bottomed bamboo basket and removes impurity, clean, dry；
（8）The fruit of Chinese wolfberry：It winnows with a dustpan net impurity, plucks remaining stalk and the base of a fruit；
（9）Prepared rehmannia root：Take crude drug, steam to surface corvinus, take out, shine to eighty per cant it is dry when, be sliced, it is dry；
（10）The fleece-flower root：Impurity is picked, is cleaned, thoroughly with bubble to eighty per cant, is pulled out, is moistened to uniform humidity inside and outside, be sliced or be cut into Square dries；
（11）Fructus Corni：It cleans, removes removal core and impurity, dry；
（12）Mulberries：It is eluted with water, picks impurity, extract long handle, dry；
（13）Ganoderma lucidum：Impurity is removed, is cleaned, is softened, cut sheet, it is dry, weed out clast；
（14）Psoralea corylifolia：It winnows with a dustpan net impurity, cleans, dry；
（15）Herba Cistanches：Net impurity is picked, clear water impregnates, changes water daily 1-2 times, be such as salty desert cistanche, steeps salinity to the greatest extent, moisturizes, longitudinal Slice, is dried；
（Two）It prepares
（1）By the Rhizoma Atractylodis Macrocephalae of the weight, ginseng, Radix Astragali, fushen, Radix Polygalae, spina date seed, Semen Cuscutae, the fruit of Chinese wolfberry, prepared rehmannia root, He Shou Crow, Fructus Corni, mulberries, ganoderma lucidum, psoralea corylifolia, Herba Cistanches are put into decocting container, add 6 times of amounts of water, after impregnating 100 minutes, intense fire Boiling is decocted, then with being cooked by slow fire 20 minutes, filters to obtain first time decoction liquor, first time decoction liquor is poured into container；
（2）The dregs of a decoction of filtering are added into 4 times of amounts of water, are boiled by intense fire, then with being cooked by slow fire 20 minutes, filter to obtain second of decoction liquor；
（3）It decoction liquor will be mixed evenly twice, and be divided into 3 doses and take.
CN201810855764.7A 2018-07-31 2018-07-31 A kind of drug and preparation method thereof for treating alpastic anemia Withdrawn CN108671076A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201810855764.7A CN108671076A (en) 2018-07-31 2018-07-31 A kind of drug and preparation method thereof for treating alpastic anemia

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201810855764.7A CN108671076A (en) 2018-07-31 2018-07-31 A kind of drug and preparation method thereof for treating alpastic anemia

Publications (1)

Publication Number Publication Date
CN108671076A true CN108671076A (en) 2018-10-19

Family

ID=63815909

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201810855764.7A Withdrawn CN108671076A (en) 2018-07-31 2018-07-31 A kind of drug and preparation method thereof for treating alpastic anemia

Country Status (1)

Country Link
CN (1) CN108671076A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107343931A (en) * 2017-08-28 2017-11-14 王文春 A kind of mastitis for the treatment of is with medicine of hyperplasia of mammary glands and preparation method thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101259190A (en) * 2008-05-04 2008-09-10 北京中科仁和科技有限公司 Chinese medicine assembly for warming kidney, compensating spleen, benefitting qi and nourishing blood and preparation thereof
CN101279013A (en) * 2008-05-04 2008-10-08 北京中科仁和科技有限公司 Chinese medicine compound for curing chronic type aplastic anemia
CN107384700A (en) * 2017-07-24 2017-11-24 桂平市蒙圩镇火炎种养专业合作社 A kind of health care fingered citron wine and preparation method thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101259190A (en) * 2008-05-04 2008-09-10 北京中科仁和科技有限公司 Chinese medicine assembly for warming kidney, compensating spleen, benefitting qi and nourishing blood and preparation thereof
CN101279013A (en) * 2008-05-04 2008-10-08 北京中科仁和科技有限公司 Chinese medicine compound for curing chronic type aplastic anemia
CN107384700A (en) * 2017-07-24 2017-11-24 桂平市蒙圩镇火炎种养专业合作社 A kind of health care fingered citron wine and preparation method thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
屈庆,等: "裴正学教授丹参临证应用心得" *
李振波,等: "复方补益中药治疗再生障碍性贫血的实验研究" *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107343931A (en) * 2017-08-28 2017-11-14 王文春 A kind of mastitis for the treatment of is with medicine of hyperplasia of mammary glands and preparation method thereof

Similar Documents

Publication Publication Date Title
CN108671076A (en) A kind of drug and preparation method thereof for treating alpastic anemia
CN103961616A (en) Medicine for treating allergic cough and preparation method thereof
CN106692845A (en) Medicament for treating diabetes and preparation method thereof
CN108524888A (en) A kind of drug and preparation method thereof for treating insomnia
CN107029163A (en) It is a kind of to treat medicine of infantile enuresis and preparation method thereof
CN106729057A (en) It is a kind of to treat medicine of nosebleed epistaxis and preparation method thereof
CN108126148A (en) For improving the Chinese herbal ointment formula of yin-deficiency constitution and its processing method
CN107823402A (en) A kind of medicine for treating impotence and preparation method thereof
CN107551135A (en) A kind of mulberry leaf disappear lipoid and reducing blood pressure tea and preparation method thereof
CN107582941A (en) A kind of medicine for treating pulmonary fibrosis and preparation method thereof
CN106692858A (en) Medicine for treating threatened abortion and preparation method of medicine
CN105343794A (en) Drug for treating neurasthenia and preparation method thereof
CN108283693A (en) A kind of drug and preparation method thereof for treating chronic enteritis
CN108404091A (en) A kind of drug and preparation method thereof for treating cardiac arrhythmia
CN107582851A (en) It is a kind of to treat drowsiness medicine and preparation method thereof
CN108295206A (en) A kind of drug and preparation method thereof for treating adolescent myopia
CN108524767A (en) It is a kind of to treat neurasthenic drug and preparation method thereof
CN108273013A (en) A kind of drug and preparation method thereof for the treatment of system hardening illness
CN108404090A (en) A kind of drug and preparation method thereof for treating pulmonary emphysema
CN108785570A (en) A kind of drug and preparation method thereof for treating Meniere disease
CN107961304A (en) A kind of medicine for treating senile cataract and preparation method thereof
CN108743902A (en) A kind of drug and preparation method thereof for treating low blood pressure
CN106924584A (en) It is a kind of to treat medicine of Sheehan's syndrome and preparation method thereof
CN108379516A (en) A kind of drug and preparation method thereof for treating headstroke
CN108310360A (en) A kind of drug and preparation method thereof for treating low blood pressure

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
WW01 Invention patent application withdrawn after publication
WW01 Invention patent application withdrawn after publication

Application publication date: 20181019