CN101259190A - Chinese medicine assembly for warming kidney, compensating spleen, benefitting qi and nourishing blood and preparation thereof - Google Patents
Chinese medicine assembly for warming kidney, compensating spleen, benefitting qi and nourishing blood and preparation thereof Download PDFInfo
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Abstract
The invention discloses a Chinese medicine combination used for warming kidney, invigorating spleen, supplementing Qi and nourishing blood and a preparation method of the Chinese medicine combination. The effective compositions of the invention are extracted from ginseng, Atractylodes macrocephaia, dodder, milk veteh, Tuckahoe, wolfberry fruit, angelica, root of herbaceous peony, old arable soil, Ligustrum lucidum, fleece-flower root, Eclipta alba, Salvia miltiorrhiza, Caulis Spatholobi, colla corii asini, pulp of cornus and Glycyrrhiza, etc. The medicinal active compositions specific to the invention has the functions of warming kidney, invigorating spleen, supplementing Qi and nourishing blood and is applicable for spleen and kidney deficiency and vital energy and blood deficiency. For clinical treatment, the medicine combination can be used for treating aplastic anemia, on-deficiency anemia, nutritional anemia, chornic anemia, drug-induced anemia or autoimmune hemolytic anemia, thrombocytopenia and aleukocytosis and so on.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicine pharmacy, be specifically related to Chinese medicine composition of a kind of the kidney warming spleen reinforcing, benefiting QI and nourishing blood and preparation method thereof.
Technical background
Aplastic anemia is called for short aplastic anemia, be to have Different types of etiopathogenises to cause that the bone marrow hematogenesis tissue obviously reduces, the syndrome of marrow hematopoiesis function failure. the typical case shows as carrying out property anemia, hemorrhage, infect, and pancytopenia, be a kind of common disease of hematopoietic system. sickness rate is 1.87/10 ten thousand populations, the patient is in the majority with person between twenty and fifty, and the male is more than the women.The cause of disease that forms aplastic anemia mostly is contact some drugs and chemical substance, various ionizing radiation, as: the X line, radionuclide or some infection etc. all can make human body generation bone marrow depression, causes the formation of aplastic anemia.
The crowd who is engaged in special industry now is not a lot of comparatively speaking; but along with the development of society and the progress of nuclear industry; be engaged in and variously have the radioactivity element and exist the people of field work more and more; though industry-by-industry has been taked protective measure for this reason, radiation problem still should obtain due attention.
The aplastic anemia etiological study shows: the factor of inducing an illness mainly contains various ionizing radiation, as X line, radiosiotope, gamma-rays, radioprotective etc.Accept radiation cure or too frequent diagnostic irradiation, the risk factor of suffering from aplastic anemia is 10 times of matched group.And relevant with dosage, dosage increases, the bone marrow injury weightening finish.Generally when surpassing acceptable dose, can cause aplastic anemia.Clinical the carrying out property anemia that mainly shows as, hemorrhage, infect, and pancytopenia (main platelet). blood routine examination: erythrocyte, leukocyte, hemoglobin, platelet plate all are lower than normal value, often with dizzy, weak, lustreless complexion, have palpitation breathe hard, the sign of deficient qi and blood such as epistaxis.
Chinese medical discrimination: aplastic anemia belongs to categories such as the traditional Chinese medical science " asthenia ", " exhaustion of blood ", " blood deficiency ", " blood depletion ", " marrow is withered ", with the function of liver spleen kidney substantial connection is arranged. and The liver and the kidney have a common source, and the main again bone of kidney is given birth to marrow, leads in brain blood stored in the liver, main catharsis, The spleen governs the blood, main fortuneization.So any one internal organs goes wrong, all can connect and other each dirty, also influential to medulla hematopoietic system.
The present invention, starts with from the cause of disease in conjunction with modern clinical experience from succession traditional Chinese medical science ancient prescription, dialectical treatment, and treating both the principal and secondary aspects of a disease is the Therapeutic Principle with the kidney warming spleen reinforcing, benefiting QI and nourishing blood.
Summary of the invention:
One of purpose of the present invention provides the Chinese medicine composition of a kind of the kidney warming spleen reinforcing, benefiting QI and nourishing blood.
Another object of the present invention provides the preparation method of this Chinese medicine composition.
Chinese medicine of the present invention is made up of active ingredient and/or pharmaceutically acceptable carrier, and wherein said active ingredient is made (part is unit of weight) by following raw materials according:
1. write out a prescription:
Radix Ginseng 100-300 part Rhizoma Atractylodis Macrocephalae 50-200 part Semen Cuscutae 50-200 part
Radix Astragali 100-300 part Poria 50-200 part Fructus Lycii 50-200 part
Radix Angelicae Sinensis 100-300 part Radix Paeoniae Alba 50-200 part Radix Rehmanniae Preparata 50-200 part
Fructus Ligustri Lucidi 50-200 part Radix Polygoni Multiflori 50-200 part Herba Ecliptae 50-200 part
Radix Salviae Miltiorrhizae 100-300 part Caulis Spatholobi 50-200 part Colla Corii Asini 50-200 part
Fructus Corni 50-200 part Radix Glycyrrhizae 50-200 part
The active component that preferred following raw materials according is made, curative effect is better:
150 parts of 150 parts of Semen Cuscutae of 200 parts of Rhizoma Atractylodis Macrocephalaes of Radix Ginseng
150 parts of 150 parts of Fructus Lycii of 200 parts of Poria of the Radix Astragali
150 parts in 150 parts of Radix Rehmanniaes Preparata of 200 portions of Radix Paeoniae Albas of Radix Angelicae Sinensis
150 parts of 150 parts of part Herba Ecliptaes of 150 parts of Radixs Polygoni Multiflori of Fructus Ligustri Lucidi
150 parts in 150 parts of Colla Corii Asini of 200 portions of Caulis Spatholobis of Radix Salviae Miltiorrhizae
100 parts in 150 portions of Radix Glycyrrhizaes of Fructus Corni
The active ingredient preparation method of Chinese medicine of the present invention can be that raw material is dry respectively, and levigation mixes.It also can be the conventional method preparation of adopting herbal pharmaceutical.These pharmacy conventional methods can be water extract-alcohol precipitation or ethanol extract from water precipitation, also have other extracting method in addition, specifically " pharmaceutics of Chinese drugs " published referring to Cao Chunlin chief editor's Shanghai science tech publishing house.
The following preparation method preparation of preferred employing:
2. preparation technology
(1) Radix Salviae Miltiorrhizae adds 75% alcohol dipping secondary, floods 48 hours for the first time, floods 24 hours for the second time, filters, and decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(2) all the other Radix Ginsengs, the Rhizoma Atractylodis Macrocephalae, Semen Cuscutae, the Radix Astragali, Poria, Fructus Lycii, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Radix Rehmanniae Preparata, Fructus Ligustri Lucidi, the Radix Polygoni Multiflori, Herba Ecliptae, Caulis Spatholobi, Fructus Corni, medical materials such as Radix Glycyrrhizae add 10 times of decoctings and boil three times, 1 hour for the first time, second, three times 0.5 hour, filter, merging filtrate, filtrate is boiled the back and is added Colla Corii Asini, stirs to make and dissolves, and concentrating under reduced pressure becomes the clear paste of 1.08～1.14 (50～60 ℃), add 2.8 times of amount ethanol, stir evenly, be heated to 60 ℃, left standstill 24 hours, filter, decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(3) step (1) get dry extract is got dry extract with step (2) mix, be ground into fine powder, add acceptable accessories and make different preparations such as granule, sheet, capsule.
Adopt mutual compatibility of above-mentioned raw material of Chinese medicine and preparation method thereof, full side has the effect of the kidney warming spleen reinforcing, benefiting QI and nourishing blood, is applicable to that the spleen kidney is two empty, the card of insufficiency of vital energy and blood.Clinical aplastic anemia, iron deficiency anemia, malnutritional anemia, anemia of chronic disease, medicine or autoimmune hemolytic anemia, thrombocytopenia, the leukopenia etc. of being used for.
By the following examples technical scheme of the present invention is described further.
Embodiment 1: the preparation method of granule
1. write out a prescription:
150 parts of 150 parts of Semen Cuscutae of 200 parts of Rhizoma Atractylodis Macrocephalaes of Radix Ginseng
150 parts of 150 parts of Fructus Lycii of 200 parts of Poria of the Radix Astragali
150 parts in 150 parts of Radix Rehmanniaes Preparata of 200 portions of Radix Paeoniae Albas of Radix Angelicae Sinensis
150 parts of 150 parts of part Herba Ecliptaes of 150 parts of Radixs Polygoni Multiflori of Fructus Ligustri Lucidi
150 parts in 150 parts of Colla Corii Asini of 200 portions of Caulis Spatholobis of Radix Salviae Miltiorrhizae
100 parts in 150 portions of Radix Glycyrrhizaes of Fructus Corni
2. preparation technology:
(1) Radix Salviae Miltiorrhizae adds 75% alcohol dipping secondary, floods 48 hours for the first time, floods 24 hours for the second time, filters, and decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(2) all the other Radix Ginsengs, the Rhizoma Atractylodis Macrocephalae, Semen Cuscutae, the Radix Astragali, Poria, Fructus Lycii, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Radix Rehmanniae Preparata, Fructus Ligustri Lucidi, the Radix Polygoni Multiflori, Herba Ecliptae, Caulis Spatholobi, Fructus Corni, medical materials such as Radix Glycyrrhizae add 10 times of decoctings and boil three times, 1 hour for the first time, second, three times 0.5 hour, filter, merging filtrate, filtrate is boiled the back and is added Colla Corii Asini, stirs to make and dissolves, and concentrating under reduced pressure becomes the clear paste of 1.08～1.14 (50～60 ℃), add 2.8 times of amount ethanol, stir evenly, be heated to 60 ℃, left standstill 24 hours, filter, decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(3) step (1) get dry extract is got dry extract with step (2) mix, add cane sugar powder, mixing is made granule, drying, promptly.
Embodiment 2: the preparation method of tablet
1. write out a prescription:
150 parts of 150 parts of Semen Cuscutae of 200 parts of Rhizoma Atractylodis Macrocephalaes of Radix Ginseng
150 parts of 150 parts of Fructus Lycii of 200 parts of Poria of the Radix Astragali
150 parts in 150 parts of Radix Rehmanniaes Preparata of 200 portions of Radix Paeoniae Albas of Radix Angelicae Sinensis
150 parts of 150 parts of part Herba Ecliptaes of 150 parts of Radixs Polygoni Multiflori of Fructus Ligustri Lucidi
150 parts in 150 parts of Colla Corii Asini of 200 portions of Caulis Spatholobis of Radix Salviae Miltiorrhizae
100 parts in 150 portions of Radix Glycyrrhizaes of Fructus Corni
2. preparation technology:
(1) Radix Salviae Miltiorrhizae adds 75% alcohol dipping secondary, floods 48 hours for the first time, floods 24 hours for the second time, filters, and decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(2) all the other Radix Ginsengs, the Rhizoma Atractylodis Macrocephalae, Semen Cuscutae, the Radix Astragali, Poria, Fructus Lycii, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Radix Rehmanniae Preparata, Fructus Ligustri Lucidi, the Radix Polygoni Multiflori, Herba Ecliptae, Caulis Spatholobi, Fructus Corni, medical materials such as Radix Glycyrrhizae add 10 times of decoctings and boil three times, 1 hour for the first time, second, three times 0.5 hour, filter, merging filtrate, filtrate is boiled the back and is added Colla Corii Asini, stirs to make and dissolves, and concentrating under reduced pressure becomes the clear paste of 1.08～1.14 (50～60 ℃), add 2.8 times of amount ethanol, stir evenly, be heated to 60 ℃, left standstill 24 hours, filter, decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(3) step (1) get dry extract is got dry extract with step (2) mix, pulverize, sieve, add starch, magnesium stearate, tabletting, promptly.
Embodiment 3: the preparation method of capsule
1. write out a prescription:
200 parts of 100 parts of Radix Et Rhizoma Rhei of 200 parts of Radix Aconiti Lateralis Preparatas of the Radix Astragali
150 parts of 150 portions of Semen Plantaginiss of 150 portions of Rhizoma Et Radix Notopterygiis of Rhizoma Pinelliae Preparata
150 parts of Bi of 150 parts of Herba Epimedii of the Radix Paeoniae Alba
100 parts
150 parts of 100 portions of Radix Cyathulaes of 200 portions of Rhizoma Alismatis of Radix Angelicae Sinensis
200 parts of 150 parts of Radixs Stephaniae Tetrandrae of 150 parts of Herba Asaris of Poria
200 parts of 150 parts of Radix Glycyrrhizae Preparatas of 100 portions of Cortex Cinnamomis of Radix Angelicae Pubescentis
200 parts of Rhizoma Chuanxiongs
2. preparation technology
(1) Radix Salviae Miltiorrhizae adds 75% alcohol dipping secondary, floods 48 hours for the first time, floods 24 hours for the second time, filters, and decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(2) all the other Radix Ginsengs, the Rhizoma Atractylodis Macrocephalae, Semen Cuscutae, the Radix Astragali, Poria, Fructus Lycii, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Radix Rehmanniae Preparata, Fructus Ligustri Lucidi, the Radix Polygoni Multiflori, Herba Ecliptae, Caulis Spatholobi, Fructus Corni, medical materials such as Radix Glycyrrhizae add 10 times of decoctings and boil three times, 1 hour for the first time, second, three times 0.5 hour, filter, merging filtrate, filtrate is boiled the back and is added Colla Corii Asini, stirs to make and dissolves, and concentrating under reduced pressure becomes the clear paste of 1.08～1.14 (50～60 ℃), add 2.8 times of amount ethanol, stir evenly, be heated to 60 ℃, left standstill 24 hours, filter, decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(3) step (1) get dry extract is got dry extract with step (2) mix, pulverize, sieve, add starch, mixing is made granule, and drying incapsulates, promptly.
Claims (5)
1, the Chinese medicine composition of a kind of the kidney warming spleen reinforcing, benefiting QI and nourishing blood is characterized in that being made up of active ingredient and/or pharmaceutically acceptable carrier, and wherein said active ingredient is made by following raw materials according:
Radix Ginseng 100-300 part Rhizoma Atractylodis Macrocephalae 50-200 part Semen Cuscutae 50-200 part
Radix Astragali 100-300 part Poria 50-200 part Fructus Lycii 50-200 part
Radix Angelicae Sinensis 100-300 part Radix Paeoniae Alba 50-200 part Radix Rehmanniae Preparata 50-200 part
Fructus Ligustri Lucidi 50-200 part Radix Polygoni Multiflori 50-200 part Herba Ecliptae 50-200 part
Radix Salviae Miltiorrhizae 100-300 part Caulis Spatholobi 50-200 part Colla Corii Asini 50-200 part
Fructus Corni 50-200 part Radix Glycyrrhizae 50-200 part.
2, the Chinese medicine composition of a kind of the kidney warming spleen reinforcing according to claim 1, benefiting QI and nourishing blood is characterized in that wherein preparing the preferred following raw materials according of described active ingredient:
150 parts of 150 parts of Semen Cuscutae of 200 parts of Rhizoma Atractylodis Macrocephalaes of Radix Ginseng
150 parts of 150 parts of Fructus Lycii of 200 parts of Poria of the Radix Astragali
150 parts in 150 parts of Radix Rehmanniaes Preparata of 200 portions of Radix Paeoniae Albas of Radix Angelicae Sinensis
150 parts of 150 parts of part Herba Ecliptaes of 150 parts of Radixs Polygoni Multiflori of Fructus Ligustri Lucidi
150 parts in 150 parts of Colla Corii Asini of 200 portions of Caulis Spatholobis of Radix Salviae Miltiorrhizae
100 parts in 150 portions of Radix Glycyrrhizaes of Fructus Corni.
3, according to the Chinese medicine composition of the described a kind of the kidney warming spleen reinforcing of claim 1-2, benefiting QI and nourishing blood, it is characterized in that adopting following method to make:
(1) Radix Salviae Miltiorrhizae adds 75% alcohol dipping secondary, floods 48 hours for the first time, floods 24 hours for the second time, filters, and decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(2) all the other Radix Ginsengs, the Rhizoma Atractylodis Macrocephalae, Semen Cuscutae, the Radix Astragali, Poria, Fructus Lycii, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Radix Rehmanniae Preparata, Fructus Ligustri Lucidi, the Radix Polygoni Multiflori, Herba Ecliptae, Caulis Spatholobi, Fructus Corni, medical materials such as Radix Glycyrrhizae add 10 times of decoctings and boil three times, 1 hour for the first time, second, three times 0.5 hour, filter, merging filtrate, filtrate is boiled the back and is added Colla Corii Asini, stirs to make and dissolves, and concentrating under reduced pressure becomes the clear paste of 1.08～1.14 (50～60 ℃), add 2.8 times of amount ethanol, stir evenly, be heated to 60 ℃, left standstill 24 hours, filter, decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(3) step (1) get dry extract is got dry extract with step (2) mix, be ground into fine powder, add acceptable accessories and make different preparations such as granule, sheet, capsule.
4, according to the Chinese medicine composition of any one described a kind of the kidney warming spleen reinforcing, benefiting QI and nourishing blood among the claim 1-3, it is characterized in that this Chinese medicine composition is an oral formulations.
5, according to the Chinese medicine composition of the described a kind of the kidney warming spleen reinforcing of claim 3-4, benefiting QI and nourishing blood, it is characterized in that this Chinese medicine composition can be made into granule, capsule, tablet.
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| CNA2008101058409A CN101259190A (en) | 2008-05-04 | 2008-05-04 | Chinese medicine assembly for warming kidney, compensating spleen, benefitting qi and nourishing blood and preparation thereof |
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| CN102727666A (en) * | 2012-05-31 | 2012-10-17 | 固镇县中医院 | Traditional Chinese medicine for treating hepatic and renal yin deficiency type thrombocytopenia |
| CN103125935A (en) * | 2013-02-02 | 2013-06-05 | 安徽惠尔普生物科技发展有限责任公司 | Fleece-flower root amino acid oral liquid and preparation method thereof |
| CN103451069A (en) * | 2013-01-14 | 2013-12-18 | 贾晋科 | Chinese medicinal liquor capable of enhancing health |
| CN103585515A (en) * | 2013-10-23 | 2014-02-19 | 青岛华仁技术孵化器有限公司 | Effervescing agent medicament for treating children alimentary anemia |
| CN104083677A (en) * | 2014-06-10 | 2014-10-08 | 凤台县中医院 | Traditional Chinese medicine composition for treating thrombocytopenia |
| CN104324145A (en) * | 2014-11-24 | 2015-02-04 | 毛艳玲 | Traditional Chinese medicine for treating leukopenia and agranulocytosis |
| CN104721411A (en) * | 2013-12-18 | 2015-06-24 | 四川省中医药科学院中医研究所 | Anemia treating drug composition, preparation method and uses thereof |
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| CN105395883A (en) * | 2016-01-13 | 2016-03-16 | 刘秀娜 | Traditional Chinese medicine for curing anemia |
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| CN106421273A (en) * | 2016-11-28 | 2017-02-22 | 广西慧投互联网金融服务有限公司 | Traditional Chinese medicine composition for treating aplastic anemia |
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| CN102727666B (en) * | 2012-05-31 | 2014-07-30 | 固镇县中医院 | Traditional Chinese medicine for treating hepatic and renal yin deficiency type thrombocytopenia |
| CN103451069A (en) * | 2013-01-14 | 2013-12-18 | 贾晋科 | Chinese medicinal liquor capable of enhancing health |
| CN103125935A (en) * | 2013-02-02 | 2013-06-05 | 安徽惠尔普生物科技发展有限责任公司 | Fleece-flower root amino acid oral liquid and preparation method thereof |
| CN103585515A (en) * | 2013-10-23 | 2014-02-19 | 青岛华仁技术孵化器有限公司 | Effervescing agent medicament for treating children alimentary anemia |
| CN104721411A (en) * | 2013-12-18 | 2015-06-24 | 四川省中医药科学院中医研究所 | Anemia treating drug composition, preparation method and uses thereof |
| CN104721411B (en) * | 2013-12-18 | 2019-10-15 | 四川省中医药科学院中医研究所 | A kind of pharmaceutical composition and its preparation method and application for treating anaemia |
| CN104083677A (en) * | 2014-06-10 | 2014-10-08 | 凤台县中医院 | Traditional Chinese medicine composition for treating thrombocytopenia |
| CN104324145A (en) * | 2014-11-24 | 2015-02-04 | 毛艳玲 | Traditional Chinese medicine for treating leukopenia and agranulocytosis |
| CN104758719B (en) * | 2015-03-19 | 2018-07-20 | 中国人民解放军第三0二医院 | A kind of Chinese medicine composition, granule and preparation method for treating leukopenia |
| CN104758719A (en) * | 2015-03-19 | 2015-07-08 | 中国人民解放军第三0二医院 | Traditional Chinese medicinal composition for treating leucocytopenia, granule thereof, and preparation methods of composition and granule |
| CN105395883A (en) * | 2016-01-13 | 2016-03-16 | 刘秀娜 | Traditional Chinese medicine for curing anemia |
| CN105663419A (en) * | 2016-03-25 | 2016-06-15 | 杨忠雅 | Formula for pure traditional Chinese medicines capable of generating new blood, dispelling extravasated blood and treating leukemia |
| CN105687715A (en) * | 2016-03-26 | 2016-06-22 | 徐鹏 | Traditional Chinese medicine composition for treating chronic benzene poisoning blood platelet and leukocyte decrease |
| CN105832967A (en) * | 2016-05-04 | 2016-08-10 | 包莉丽 | Drug for treating autoimmune hemolytic anemia |
| CN106309914A (en) * | 2016-08-25 | 2017-01-11 | 陈方 | Traditional Chinese medicine oral liquid for treating anemia |
| CN106421273A (en) * | 2016-11-28 | 2017-02-22 | 广西慧投互联网金融服务有限公司 | Traditional Chinese medicine composition for treating aplastic anemia |
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