CN101543609A - Traditional Chinese medicine for treating breast cancer and preparation method thereof - Google Patents
Traditional Chinese medicine for treating breast cancer and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine for treating breast cancer and a preparation method thereof. The traditional Chinese medicine comprises functional ingredients and/or pharmaceutically acceptable carriers, wherein the functional ingredients are prepared by extracting radix astragali, codonopsis pilosula, turmeric root tuber, Chinese angelica, eclipta alba, cimicifuga foetida, white atractylodes rhizome, ligusticum wallichii, bighead atractylodes rhizome, red paeony root, honeysuckle flower, paris polyphylla, red-rooted salvia root, Chinese cinnamon, coix seed, calcite, and the like. The traditional Chinese medicine has the efficacies of invigorating vital energy and nourishing blood, invigorating spleen and dispersing stagnated liver-energy, dissolving blood stasis and detoxifying, can strengthen the immunologic function of patients with breast cancer, regulate the anti-cancer ability of a human body, and play the roles of resisting cancer, raising efficiency, reducing toxicity, and the like.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicine pharmacy, be specifically related to Chinese medicine for the treatment of breast carcinoma and preparation method thereof.
Technical background
Breast carcinoma is meant the lobule that betides mammary gland and the malignant tumor of ductal epithelium, is one of modal cancer of women.The women accounts for 99% in China patient with breast cancer.The factor that influences the breast carcinoma morbidity has ovarian dysfunction, hyperfunction, single women of estrogen secretion and undesired suckling, heredity etc. after marriage.Breast carcinoma 30 years old was more rare in the past, occurred in the women before and after 40-60 year and menopause mostly.Often be divided into two big classes on the pathology: grade malignancy the higher person (inocarcinoma, medullary carcinoma, inflammatory breast cancer), grade malignancy junior (papillary carcinoma, duct carcinoma, eczematoid carcinoma of nipple, lobular carcinoma).
The cause of disease of breast carcinoma is still not fully aware of at present, may be relevant with factors such as inherited genetic factors, endocrine disturbance, chronic stimulations.Other may be also and high fat diet absorption increase, hypothyroidism, suckling are few, do not educate after marriage etc. that factor is relevant.The primary disease cardinal symptom shows as lump in breast, and the lump position is more common, strong but pliable in texture with the outer top of breast, obscure boundary Chu, and the circular or oval enclosed mass of irregular terrain profiles, the overwhelming majority is a single-shot.As invade and skin, then breast forms change outward, the skin chap, thickens, and shows as the Pericarpium Citri Reticulatae sample and changes, and contracts in nipple presents, fixing or nipple courage and uprightness ooze changes such as soup, cancerous eczema.Late period, the skin diabrosis can be the magic flower shape.Early stage no pain, late period, pain was acute.Submental lymph nodes is because of the transfer enlargement on oxter and the clavicle.General Symptoms is become thin, anemia, cachexia etc.Lung, pleura, liver, brain, kidney can take place in hematogenous spread, bone shifts and cause death.
The diagnosis of breast carcinoma can be carried out the inspection of mammary X-ray plain film, biopsy, thermocouple thermal detector and infrared temperature according to the lump at mammary gland place and takes pictures and can make a definite diagnosis, and relative equilibrium, thereby the immunocompetence of enhancing body reach the purpose of curing cancer.
The traditional Chinese medical science is comparatively detailed to the record of breast carcinoma, and ancient Chinese medicine doctor is categories such as " breast carcinoma ", " mammary calculus carbuncle ", " stone breast " to this sick calculation according to its clinical manifestation is many.Chinese medicine thinks that primary disease is many by disorder of emotion, depression of liver-QI or because of Chong and Ren channel disorder, QI-blood circulation is not smooth, and qi stagnation hemagglutination, meridians block, and knot stagnates due to the Ruzhong.
From later stage the 1950's so far, carried out the anticancer clinical and experimentation work of a large amount of Chinese medicines both at home and abroad, comprise research two aspects of research with the traditional medication of the traditional Chinese medical science of single medicinal material effective ingredient and derivant.Offer report and clinical experience in conjunction with the side, Chinese medicine is by regulating body's immunological function, transfer the anti-cancer ability of body self, and plays effect such as anticancer, efficacy enhancing and toxicity reducing.
The present invention is prepared from conjunction with modern Chinese medicine pharmacy theory according to folk remedy, and the present invention is than the convenient transportation that has of original decoction, is easy to storage, conveniently takes to wait and has a few.
Summary of the invention:
One of purpose of the present invention provides the Chinese medicine of treatment breast carcinoma.
Another object of the present invention provides the preparation method of this drug regimen.
Chinese medicine of the present invention is made up of active ingredient and/or pharmaceutically acceptable carrier, and wherein said active ingredient is made (part is unit of weight) by following raw materials according:
1. write out a prescription:
100-300 parts of 150-450 parts of Radix Curcumaes of 150-450 parts of Radix Codonopsis of the Radix Astragali
50-150 parts of 100-300 parts of Rhizoma Cimicifugaes of 150-450 parts of Herba Ecliptaes of Radix Angelicae Sinensis
100-300 parts of 100-300 parts of Radix Paeoniae Albas of 100-300 parts of Rhizoma Chuanxiongs of the Rhizoma Atractylodis Macrocephalae
100-300 parts of 100-300 parts of Rhizoma Paridis of 100-300 parts of Flos Lonicerae of Radix Paeoniae Rubra
50-150 parts of 100-300 parts of Semen Coiciss of 100-300 parts of Cortex cinnamomi japonici (Ramulus Cinnamomi)s of Radix Salviae Miltiorrhizae
50-150 parts of LIAOJIANGSHI
The active component that preferred following raw materials according is made, curative effect is better:
150 parts of 300 portions of Radix Curcumaes of 300 parts of Radix Codonopsis of the Radix Astragali
100 parts of 150 parts of Rhizoma Cimicifugaes of 300 portions of Herba Ecliptaes of Radix Angelicae Sinensis
150 parts of 150 portions of Radix Paeoniae Albas of 150 parts of Rhizoma Chuanxiongs of the Rhizoma Atractylodis Macrocephalae
150 parts of 150 parts of Rhizoma Paridis of 150 parts of Flos Lonicerae of Radix Paeoniae Rubra
100 parts of 150 parts of Semen Coiciss of 150 parts of Cortex cinnamomi japonici (Ramulus Cinnamomi)s of Radix Salviae Miltiorrhizae
100 parts of LIAOJIANGSHI
The active ingredient preparation method of Chinese medicine of the present invention can be that raw material is dry respectively, and levigation mixes.It also can be the conventional method preparation of adopting herbal pharmaceutical.These pharmacy conventional methods can be water extract-alcohol precipitation or ethanol extract from water precipitation, also have other extracting method in addition, specifically " pharmaceutics of Chinese drugs " published referring to Cao Chunlin chief editor's Shanghai science tech publishing house.
The following preparation method preparation of preferred employing:
2. preparation technology
(1) Radix Astragali, Radix Codonopsis, Radix Angelicae Sinensis, Rhizoma Chuanxiong add 80% alcohol dipping three times, flood 48 hours for the first time, and second and third time flooded respectively 24 hours, filter, and decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(2) medical materials such as all the other Radix Curcumaes, Herba Ecliptae, Rhizoma Cimicifugae, the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, Radix Paeoniae Rubra, Flos Lonicerae, Rhizoma Paridis, Radix Salviae Miltiorrhizae, Cortex cinnamomi japonici (Ramulus Cinnamomi), Semen Coicis, LIAOJIANGSHI add 10 times of decoctings and boil three times, and 1 hour for the first time, second and third time 0.5 hour, filter, merging filtrate, filtrate is condensed into the clear paste that relative density is 1.08～1.14 (50～60 ℃), add 2.8 times of amount ethanol, stir evenly, be heated to 60 ℃, left standstill 24 hours, filter, decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(3) step (1) get dry extract is got dry extract with step (2) mix, be ground into fine powder, add acceptable accessories and make different preparations such as granule, sheet, capsule.
Adopt mutual compatibility of above-mentioned raw material of Chinese medicine and preparation method thereof, full side has benefiting qi and nourishing blood, invigorating the spleen and relieving depression of liver-QI, the effect of dissolving blood stasis and detoxication.Can strengthen patient with breast cancer's immunologic function, transfer the anti-cancer ability of body self, and play effect such as anticancer, efficacy enhancing and toxicity reducing.
By the following examples technical scheme of the present invention is described further.
Embodiment 1: the preparation method of granule
1. write out a prescription:
150 parts of 300 portions of Radix Curcumaes of 300 parts of Radix Codonopsis of the Radix Astragali
100 parts of 150 parts of Rhizoma Cimicifugaes of 300 portions of Herba Ecliptaes of Radix Angelicae Sinensis
150 parts of 150 portions of Radix Paeoniae Albas of 150 parts of Rhizoma Chuanxiongs of the Rhizoma Atractylodis Macrocephalae
150 parts of 150 parts of Rhizoma Paridis of 150 parts of Flos Lonicerae of Radix Paeoniae Rubra
100 parts of 150 parts of Semen Coiciss of 150 parts of Cortex cinnamomi japonici (Ramulus Cinnamomi)s of Radix Salviae Miltiorrhizae
100 parts of LIAOJIANGSHI
2. preparation technology
(1) Radix Astragali, Radix Codonopsis, Radix Angelicae Sinensis, Rhizoma Chuanxiong add 80% alcohol dipping three times, flood 48 hours for the first time, and second and third time flooded respectively 24 hours, filter, and decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(2) medical materials such as all the other Radix Curcumaes, Herba Ecliptae, Rhizoma Cimicifugae, the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, Radix Paeoniae Rubra, Flos Lonicerae, Rhizoma Paridis, Radix Salviae Miltiorrhizae, Cortex cinnamomi japonici (Ramulus Cinnamomi), Semen Coicis, LIAOJIANGSHI add 10 times of decoctings and boil three times, and 1 hour for the first time, second and third time 0.5 hour, filter, merging filtrate, filtrate is condensed into the clear paste that relative density is 1.08～1.14 (50～60 ℃), add 2.8 times of amount ethanol, stir evenly, be heated to 60 ℃, left standstill 24 hours, filter, decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(3) step (1) get dry extract is got dry extract with step (2) mix, add cane sugar powder, mixing is made granule, drying, promptly.
Embodiment 2: the preparation method of tablet
1. write out a prescription:
150 parts of 300 portions of Radix Curcumaes of 300 parts of Radix Codonopsis of the Radix Astragali
100 parts of 150 parts of Rhizoma Cimicifugaes of 300 portions of Herba Ecliptaes of Radix Angelicae Sinensis
150 parts of 150 portions of Radix Paeoniae Albas of 150 parts of Rhizoma Chuanxiongs of the Rhizoma Atractylodis Macrocephalae
150 parts of 150 parts of Rhizoma Paridis of 150 parts of Flos Lonicerae of Radix Paeoniae Rubra
100 parts of 150 parts of Semen Coiciss of 150 parts of Cortex cinnamomi japonici (Ramulus Cinnamomi)s of Radix Salviae Miltiorrhizae
100 parts of LIAOJIANGSHI
2. preparation technology
(1) Radix Astragali, Radix Codonopsis, Radix Angelicae Sinensis, Rhizoma Chuanxiong add 80% alcohol dipping three times, flood 48 hours for the first time, and second and third time flooded respectively 24 hours, filter, and decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(2) medical materials such as all the other Radix Curcumaes, Herba Ecliptae, Rhizoma Cimicifugae, the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, Radix Paeoniae Rubra, Flos Lonicerae, Rhizoma Paridis, Radix Salviae Miltiorrhizae, Cortex cinnamomi japonici (Ramulus Cinnamomi), Semen Coicis, LIAOJIANGSHI add 10 times of decoctings and boil three times, and 1 hour for the first time, second and third time 0.5 hour, filter, merging filtrate, filtrate is condensed into the clear paste that relative density is 1.08～1.14 (50～60 ℃), add 2.8 times of amount ethanol, stir evenly, be heated to 60 ℃, left standstill 24 hours, filter, decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(3) step (1) get dry extract is got dry extract with step (2) mix, pulverize, sieve, add starch, magnesium stearate, tabletting, promptly.
Embodiment 3: the preparation method of capsule
1. write out a prescription:
150 parts of 300 portions of Radix Curcumaes of 300 parts of Radix Codonopsis of the Radix Astragali
100 parts of 150 parts of Rhizoma Cimicifugaes of 300 portions of Herba Ecliptaes of Radix Angelicae Sinensis
150 parts of 150 portions of Radix Paeoniae Albas of 150 parts of Rhizoma Chuanxiongs of the Rhizoma Atractylodis Macrocephalae
150 parts of 150 parts of Rhizoma Paridis of 150 parts of Flos Lonicerae of Radix Paeoniae Rubra
100 parts of 150 parts of Semen Coiciss of 150 parts of Cortex cinnamomi japonici (Ramulus Cinnamomi)s of Radix Salviae Miltiorrhizae
100 parts of LIAOJIANGSHI
2. preparation technology
(1) Radix Astragali, Radix Codonopsis, Radix Angelicae Sinensis, Rhizoma Chuanxiong add 80% alcohol dipping three times, flood 48 hours for the first time, and second and third time flooded respectively 24 hours, filter, and decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(2) medical materials such as all the other Radix Curcumaes, Herba Ecliptae, Rhizoma Cimicifugae, the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, Radix Paeoniae Rubra, Flos Lonicerae, Rhizoma Paridis, Radix Salviae Miltiorrhizae, Cortex cinnamomi japonici (Ramulus Cinnamomi), Semen Coicis, LIAOJIANGSHI add 10 times of decoctings and boil three times, and 1 hour for the first time, second and third time 0.5 hour, filter, merging filtrate, filtrate is condensed into the clear paste that relative density is 1.08～1.14 (50～60 ℃), add 2.8 times of amount ethanol, stir evenly, be heated to 60 ℃, left standstill 24 hours, filter, decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(3) step (1) get dry extract is got dry extract with step (2) mix, pulverize, sieve, add starch, mixing is made granule, and drying incapsulates, promptly.
Claims (5)
1, the Chinese medicine of treatment breast carcinoma is characterized in that being made up of active ingredient and/or pharmaceutically acceptable carrier, and wherein said active ingredient is made by following raw materials according:
100-300 parts of 150-450 parts of Radix Curcumaes of 150-450 parts of Radix Codonopsis of the Radix Astragali
50-150 parts of 100-300 parts of Rhizoma Cimicifugaes of 150-450 parts of Herba Ecliptaes of Radix Angelicae Sinensis
100-300 parts of 100-300 parts of Radix Paeoniae Albas of 100-300 parts of Rhizoma Chuanxiongs of the Rhizoma Atractylodis Macrocephalae
100-300 parts of 100-300 parts of Rhizoma Paridis of 100-300 parts of Flos Lonicerae of Radix Paeoniae Rubra
50-150 parts of 100-300 parts of Semen Coiciss of 100-300 parts of Cortex cinnamomi japonici (Ramulus Cinnamomi)s of Radix Salviae Miltiorrhizae
50-150 parts of LIAOJIANGSHI.
2, the Chinese medicine of treatment breast carcinoma according to claim 1 is characterized in that wherein preparing the preferred following raw materials according of described active ingredient:
150 parts of 300 portions of Radix Curcumaes of 300 parts of Radix Codonopsis of the Radix Astragali
100 parts of 150 parts of Rhizoma Cimicifugaes of 300 portions of Herba Ecliptaes of Radix Angelicae Sinensis
150 parts of 150 portions of Radix Paeoniae Albas of 150 parts of Rhizoma Chuanxiongs of the Rhizoma Atractylodis Macrocephalae
150 parts of 150 parts of Rhizoma Paridis of 150 parts of Flos Lonicerae of Radix Paeoniae Rubra
100 parts of 150 parts of Semen Coiciss of 150 parts of Cortex cinnamomi japonici (Ramulus Cinnamomi)s of Radix Salviae Miltiorrhizae
100 parts of LIAOJIANGSHI.
3,, it is characterized in that adopting following method to make according to the Chinese medicine of the described treatment breast carcinoma of claim 1-2:
(1) Radix Astragali, Radix Codonopsis, Radix Angelicae Sinensis, Rhizoma Chuanxiong add 80% alcohol dipping three times, flood 48 hours for the first time, and second and third time flooded respectively 24 hours, filter, and decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(2) medical materials such as all the other Radix Curcumaes, Herba Ecliptae, Rhizoma Cimicifugae, the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, Radix Paeoniae Rubra, Flos Lonicerae, Rhizoma Paridis, Radix Salviae Miltiorrhizae, Cortex cinnamomi japonici (Ramulus Cinnamomi), Semen Coicis, LIAOJIANGSHI add 10 times of decoctings and boil three times, and 1 hour for the first time, second and third time 0.5 hour, filter, merging filtrate, filtrate is condensed into the clear paste that relative density is 1.08～1.14 (50～60 ℃), add 2.8 times of amount ethanol, stir evenly, be heated to 60 ℃, left standstill 24 hours, filter, decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(3) step (1) get dry extract is got dry extract with step (2) mix, be ground into fine powder, add acceptable accessories and make different preparations such as granule, sheet, capsule.
4,, it is characterized in that this Chinese medicine composition is an oral formulations according to the Chinese medicine of any one described treatment breast carcinoma among the claim 1-3.
5,, it is characterized in that this Chinese medicine composition can be made into granule, capsule, tablet according to the Chinese medicine of the described treatment breast carcinoma of claim 3-4.
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| CN200810102950A CN101543609A (en) | 2008-03-28 | 2008-03-28 | Traditional Chinese medicine for treating breast cancer and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102614208A (en) * | 2012-02-25 | 2012-08-01 | 中国科学院昆明植物研究所 | Application of compound (20R,24R)-24,25-16,23-23,27-triepoxy-12-acetoxyl-9,19-cyclolanostanol-3-O-beta-D xylopyranoside in pharmacy |
| CN105770660A (en) * | 2016-05-29 | 2016-07-20 | 贾洪军 | Preparation method of medicine preparation for treating leukemia through adjuvant radiotherapy method |
| CN105853856A (en) * | 2016-05-29 | 2016-08-17 | 贾洪军 | Pharmaceutical preparation for treating leukemia by cooperating with radiotherapy |
-
2008
- 2008-03-28 CN CN200810102950A patent/CN101543609A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102614208A (en) * | 2012-02-25 | 2012-08-01 | 中国科学院昆明植物研究所 | Application of compound (20R,24R)-24,25-16,23-23,27-triepoxy-12-acetoxyl-9,19-cyclolanostanol-3-O-beta-D xylopyranoside in pharmacy |
| CN105770660A (en) * | 2016-05-29 | 2016-07-20 | 贾洪军 | Preparation method of medicine preparation for treating leukemia through adjuvant radiotherapy method |
| CN105853856A (en) * | 2016-05-29 | 2016-08-17 | 贾洪军 | Pharmaceutical preparation for treating leukemia by cooperating with radiotherapy |
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Open date: 20090930 |