CN101628098A - Medicinal composition used for treating fatty liver and preparation method thereof - Google Patents
Medicinal composition used for treating fatty liver and preparation method thereof Download PDFInfo
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- CN101628098A CN101628098A CN200810116836A CN200810116836A CN101628098A CN 101628098 A CN101628098 A CN 101628098A CN 200810116836 A CN200810116836 A CN 200810116836A CN 200810116836 A CN200810116836 A CN 200810116836A CN 101628098 A CN101628098 A CN 101628098A
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Abstract
The invention discloses a medicinal composition used for treating fatty liver and a preparation method thereof. The effective components of the medicinal composition are extracted from the following medicinal materials: dark plum fruit, baical skullcap root, glossy privet fruit, Chinese angelica, Chinese magnoliavine fruit, hawthorn fruit, bitter orange, tuber fleeceflower root, stir-fried spiny jujube, hiraute shiny bugleweed herb, danshen root, fetid cassia, officinal magnolia bark, villous amomum fruit, raw licorice root, and the like. The medicinal composition has ideal therapeutic effects on non-alcoholic fatty liver.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicine pharmacy, be specifically related to a kind of drug regimen for the treatment of fatty liver and preparation method thereof.
Technical background
The fat of human body has two big classes, and a class is a neutral fat, neutral fat can with people's nutriture and body active what change.Another kind of is lipoid, comprises phospholipid, cholesterol and cholesterol ester, is the important component part of human body cell film, also is the important source material of synthetic cholate, vitamin D, steroid hormone, is changeless.
Under normal circumstances, liver only contains little fat, accounts for the 4%-7% of liver weight, and wherein half is a neutral fat, and all the other are lecithin and a spot of cholesterol.Under some abnormal conditions, the fat content in the liver increases, when its fat content surpass liver weight (weight in wet base) 10% the time be fatty liver.Surpassing 10%-25% is the moderate fatty liver, and surpassing 25%-50% is severe fatty liver.
Fatty liver can be divided into two types of ethanol and non-alcoholics clinically.Alcoholic fatty liver with drink relevantly, non-alcoholic fatty liver disease great majority are still with fat relevant with diabetes.
Along with the change of diet and living habit, the incidence rate of non-alcoholic fatty liver disease is improving year by year, has caused in the world the great attention to this disease.Except the reason such as alcohol prohibition, diet control, modest movement and blood sugar control that cause disease at correction, the traditional Chinese medical science thinks that non-alcoholic fatty liver disease belongs to " the lump at the left hypochondrium disease " of the traditional Chinese medical science, " long-pending card ", finally form damp-phlegm stasis of blood resistance knot mutually with the liver failing to maintain the normal flow of QI, dysfunction of the spleen in transportation, retention of damp-heat in the interior, the turbid pent-up of expectorant, stagnation of blood stasis, liver blockage of the vessel and form fatty liver.
Fatty liver belongs to motherland's medical science " hypochondriac pain ", " gathering ", " syndrome of feeling fullness and distension in the upper abdomen " category.According to its clinical manifestation, national standard is named and is " liver addiction ".The primary disease origin cause of formation, exopathogenic factor mostly are the feed greasy and surfeit flavour or are addicted to drink immoderately, give birth to the wet expectorant of making; Endogenous cause of ill is then by the liver failing to maintain the normal flow of QI, dysfunction of the spleen in transportation, and the kidney flatusization, water is wet can not to be turned to precise and tinyly, poly-and be the wet expectorant that is, and stasis of blood resistance liver network is stranded in liver and forms primary disease.
At drug treatment, modern medicine still lacks ideal specificity medicine, mainly from protect the liver, the medication of suiting the medicine to the illness such as blood fat reducing starts with, but the fat-reducing medicament that wherein is applied to hyperlipemia usually is to the effect of fatty liver and be worth and how on earth do not obtain as yet certainly, because of some blood lipid-lowering medicine diminishes the liver side effect, with it improper possibility that the weight fat liver is arranged on the contrary.Therefore, accepted by increasing patient at the Chinese medicine of China's fatty liver.
Summary of the invention:
One of purpose of the present invention provides a kind of drug regimen for the treatment of fatty liver.
Another object of the present invention provides the preparation method of this drug regimen.
Chinese medicine of the present invention is made up of active ingredient and/or pharmaceutically acceptable carrier, and wherein said active ingredient is made (part is unit of weight) by following raw materials according:
1. write out a prescription:
Fructus Mume 60-180 part Radix Scutellariae 80-240 part Fructus Ligustri Lucidi 60-180 part
Radix Angelicae Sinensis 80-240 part Fructus Schisandrae Chinensis 80-240 part Fructus Crataegi 60-180 part
Fructus Aurantii 80-240 part Radix Polygoni Multiflori 80-240 part Semen Ziziphi Spinosae (parched) 60-180 part
Herba Lycopi 60-180 part Radix Salviae Miltiorrhizae 80-240 part Semen Cassiae 60-180 part
Cortex Magnoliae Officinalis 80-240 part Fructus Amomi 60-180 part Radix Glycyrrhizae 60-180 part
The active component that preferred following raw materials according is made, curative effect is better:
120 parts of 160 parts of Fructus Ligustri Lucidi of 120 parts of Radix Scutellariaes of Fructus Mume
120 parts of 160 portions of Fructus Crataegis of 160 parts of Fructus Schisandrae Chinensis of Radix Angelicae Sinensis
120 parts of 160 parts of Semen Ziziphi Spinosae (parched)s of 160 parts of Radix Polygoni Multiflori of Fructus Aurantii
120 parts of 160 parts of Semen Cassiae of 120 parts of Radix Salviae Miltiorrhizaes of Herba Lycopi
120 parts of 120 parts of Radix Glycyrrhizae of 160 parts of Fructus Amomis of Cortex Magnoliae Officinalis
The active ingredient preparation method of Chinese medicine of the present invention can be that raw material is dry respectively, and levigation mixes.It also can be the conventional method preparation of adopting herbal pharmaceutical.These pharmacy conventional methods can be water extract-alcohol precipitation or ethanol extract from water precipitation, also have other extracting method in addition, specifically " pharmaceutics of Chinese drugs " published referring to Cao Chunlin chief editor's Shanghai science tech publishing house.
The following preparation method preparation of preferred employing:
2. preparation technology
(1) Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae add 85% alcohol dipping secondary, flood 48 hours for the first time, flood 24 hours for the second time, filter, and decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(2) medical materials such as all the other Fructus Mumes, Radix Scutellariae, Fructus Ligustri Lucidi, Fructus Schisandrae Chinensis, Fructus Crataegi, Fructus Aurantii, Radix Polygoni Multiflori, Semen Ziziphi Spinosae (parched), Herba Lycopi, Semen Cassiae, Cortex Magnoliae Officinalis, Fructus Amomi, Radix Glycyrrhizae add 10 times of decoctings and boil three times, 1 hour for the first time, second and third time 0.5 hour, filter, merging filtrate, filtrate is condensed into the clear paste that relative density is 1.08～1.14 (50～60 ℃), add 2.8 times of amount ethanol, stir evenly, be heated to 60 ℃, left standstill 24 hours, filter, decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(3) step (1) get dry extract is got dry extract with step (2) mix, be ground into fine powder, add acceptable accessories and make different preparations such as granule, sheet, capsule.
By the following examples technical scheme of the present invention is described further.
Specific embodiment
Embodiment 1: the preparation method of granule
1. write out a prescription:
120 parts of 160 parts of Fructus Ligustri Lucidi of 120 parts of Radix Scutellariaes of Fructus Mume
120 parts of 160 portions of Fructus Crataegis of 160 parts of Fructus Schisandrae Chinensis of Radix Angelicae Sinensis
120 parts of 160 parts of Semen Ziziphi Spinosae (parched)s of 160 parts of Radix Polygoni Multiflori of Fructus Aurantii
120 parts of 160 parts of Semen Cassiae of 120 parts of Radix Salviae Miltiorrhizaes of Herba Lycopi
120 parts of 120 parts of Radix Glycyrrhizae of 160 parts of Fructus Amomis of Cortex Magnoliae Officinalis
2. preparation technology:
(1) Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae add 85% alcohol dipping secondary, flood 48 hours for the first time, flood 24 hours for the second time, filter, and decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(2) medical materials such as all the other Fructus Mumes, Radix Scutellariae, Fructus Ligustri Lucidi, Fructus Schisandrae Chinensis, Fructus Crataegi, Fructus Aurantii, Radix Polygoni Multiflori, Semen Ziziphi Spinosae (parched), Herba Lycopi, Semen Cassiae, Cortex Magnoliae Officinalis, Fructus Amomi, Radix Glycyrrhizae add 10 times of decoctings and boil three times, 1 hour for the first time, second and third time 0.5 hour, filter, merging filtrate, filtrate is condensed into the clear paste that relative density is 1.08～1.14 (50～60 ℃), add 2.8 times of amount ethanol, stir evenly, be heated to 60 ℃, left standstill 24 hours, filter, decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(3) step (1) get dry extract is got dry extract with step (2) mix, add cane sugar powder, mixing is made granule, drying, promptly.
Embodiment 2: the preparation method of tablet
1. write out a prescription:
120 parts of 160 parts of Fructus Ligustri Lucidi of 120 parts of Radix Scutellariaes of Fructus Mume
120 parts of 160 portions of Fructus Crataegis of 160 parts of Fructus Schisandrae Chinensis of Radix Angelicae Sinensis
120 parts of 160 parts of Semen Ziziphi Spinosae (parched)s of 160 parts of Radix Polygoni Multiflori of Fructus Aurantii
120 parts of 160 parts of Semen Cassiae of 120 parts of Radix Salviae Miltiorrhizaes of Herba Lycopi
120 parts of 120 parts of Radix Glycyrrhizae of 160 parts of Fructus Amomis of Cortex Magnoliae Officinalis
2. preparation technology:
(1) Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae add 85% alcohol dipping secondary, flood 48 hours for the first time, flood 24 hours for the second time, filter, and decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(2) medical materials such as all the other Fructus Mumes, Radix Scutellariae, Fructus Ligustri Lucidi, Fructus Schisandrae Chinensis, Fructus Crataegi, Fructus Aurantii, Radix Polygoni Multiflori, Semen Ziziphi Spinosae (parched), Herba Lycopi, Semen Cassiae, Cortex Magnoliae Officinalis, Fructus Amomi, Radix Glycyrrhizae add 10 times of decoctings and boil three times, 1 hour for the first time, second and third time 0.5 hour, filter, merging filtrate, filtrate is condensed into the clear paste that relative density is 1.08～1.14 (50～60 ℃), add 2.8 times of amount ethanol, stir evenly, be heated to 60 ℃, left standstill 24 hours, filter, decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(3) step (1) get dry extract is got dry extract with step (2) mix, pulverize, sieve, add starch, magnesium stearate, tabletting, promptly.
Embodiment 3: the preparation method of capsule
1. write out a prescription:
120 parts of 160 parts of Fructus Ligustri Lucidi of 120 parts of Radix Scutellariaes of Fructus Mume
120 parts of 160 portions of Fructus Crataegis of 160 parts of Fructus Schisandrae Chinensis of Radix Angelicae Sinensis
120 parts of 160 parts of Semen Ziziphi Spinosae (parched)s of 160 parts of Radix Polygoni Multiflori of Fructus Aurantii
120 parts of 160 parts of Semen Cassiae of 120 parts of Radix Salviae Miltiorrhizaes of Herba Lycopi
120 parts of 120 parts of Radix Glycyrrhizae of 160 parts of Fructus Amomis of Cortex Magnoliae Officinalis
2. preparation technology:
(1) Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae add 85% alcohol dipping secondary, flood 48 hours for the first time, flood 24 hours for the second time, filter, and decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(2) medical materials such as all the other Fructus Mumes, Radix Scutellariae, Fructus Ligustri Lucidi, Fructus Schisandrae Chinensis, Fructus Crataegi, Fructus Aurantii, Radix Polygoni Multiflori, Semen Ziziphi Spinosae (parched), Herba Lycopi, Semen Cassiae, Cortex Magnoliae Officinalis, Fructus Amomi, Radix Glycyrrhizae add 10 times of decoctings and boil three times, 1 hour for the first time, second and third time 0.5 hour, filter, merging filtrate, filtrate is condensed into the clear paste that relative density is 1.08～1.14 (50～60 ℃), add 2.8 times of amount ethanol, stir evenly, be heated to 60 ℃, left standstill 24 hours, filter, decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(3) step (1) get dry extract is got dry extract with step (2) mix, pulverize, sieve, add starch, mixing is made granule, and drying incapsulates, promptly.
Claims (5)
1, a kind of drug regimen for the treatment of fatty liver is characterized in that being made up of active ingredient and/or pharmaceutically acceptable carrier, and wherein said active ingredient is made by following raw materials according:
Fructus Mume 60-180 part Radix Scutellariae 80-240 part Fructus Ligustri Lucidi 60-180 part
Radix Angelicae Sinensis 80-240 part Fructus Schisandrae Chinensis 80-240 part Fructus Crataegi 60-180 part
Fructus Aurantii 80-240 part Radix Polygoni Multiflori 80-240 part Semen Ziziphi Spinosae (parched) 60-180 part
Herba Lycopi 60-180 part Radix Salviae Miltiorrhizae 80-240 part Semen Cassiae 60-180 part
Cortex Magnoliae Officinalis 80-240 part Fructus Amomi 60-180 part Radix Glycyrrhizae 60-180 part.
2, a kind of drug regimen for the treatment of fatty liver according to claim 1 is characterized in that wherein preparing the preferred following raw materials according of described active ingredient:
120 parts of 160 parts of Fructus Ligustri Lucidi of 120 parts of Radix Scutellariaes of Fructus Mume
120 parts of 160 portions of Fructus Crataegis of 160 parts of Fructus Schisandrae Chinensis of Radix Angelicae Sinensis
120 parts of 160 parts of Semen Ziziphi Spinosae (parched)s of 160 parts of Radix Polygoni Multiflori of Fructus Aurantii
120 parts of 160 parts of Semen Cassiae of 120 parts of Radix Salviae Miltiorrhizaes of Herba Lycopi
120 parts of 120 parts of Radix Glycyrrhizae of 160 parts of Fructus Amomis of Cortex Magnoliae Officinalis.
3, according to the described a kind of drug regimen for the treatment of fatty liver of claim 1-2, it is characterized in that adopting following method to make:
(1) Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae add 85% alcohol dipping secondary, flood 48 hours for the first time, flood 24 hours for the second time, filter, and decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(2) medical materials such as all the other Fructus Mumes, Radix Scutellariae, Fructus Ligustri Lucidi, Fructus Schisandrae Chinensis, Fructus Crataegi, Fructus Aurantii, Radix Polygoni Multiflori, Semen Ziziphi Spinosae (parched), Herba Lycopi, Semen Cassiae, Cortex Magnoliae Officinalis, Fructus Amomi, Radix Glycyrrhizae add 10 times of decoctings and boil three times, 1 hour for the first time, second and third time 0.5 hour, filter, merging filtrate, filtrate is condensed into the clear paste that relative density is 1.08～1.14 (50～60 ℃), add 2.8 times of amount ethanol, stir evenly, be heated to 60 ℃, left standstill 24 hours, filter, decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(3) step (1) get dry extract is got dry extract with step (2) mix, be ground into fine powder, add acceptable accessories and make different preparations such as granule, sheet, capsule.
4, according to any one described a kind of drug regimen for the treatment of fatty liver among the claim 1-3, it is characterized in that this Chinese medicine composition is an oral formulations.
5, according to the described a kind of drug regimen for the treatment of fatty liver of claim 3-4, it is characterized in that this Chinese medicine composition can be made into granule, capsule, tablet.
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| Application Number | Priority Date | Filing Date | Title |
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| CN200810116836A CN101628098A (en) | 2008-07-18 | 2008-07-18 | Medicinal composition used for treating fatty liver and preparation method thereof |
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| CN200810116836A CN101628098A (en) | 2008-07-18 | 2008-07-18 | Medicinal composition used for treating fatty liver and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102688451A (en) * | 2012-05-25 | 2012-09-26 | 王兴辉 | Chinese medicinal composition for treating alcoholic fatty liver |
| CN103007081A (en) * | 2012-11-27 | 2013-04-03 | 鞠法红 | Traditional Chinese medicine composition for curing non-alcoholic fatty liver disease |
| CN106109767A (en) * | 2016-07-13 | 2016-11-16 | 郑亮 | A kind of compound preparation preventing and treating non-alcohol fatty liver |
-
2008
- 2008-07-18 CN CN200810116836A patent/CN101628098A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102688451A (en) * | 2012-05-25 | 2012-09-26 | 王兴辉 | Chinese medicinal composition for treating alcoholic fatty liver |
| CN102688451B (en) * | 2012-05-25 | 2013-08-21 | 王兴辉 | Chinese medicinal composition for treating alcoholic fatty liver |
| CN103007081A (en) * | 2012-11-27 | 2013-04-03 | 鞠法红 | Traditional Chinese medicine composition for curing non-alcoholic fatty liver disease |
| CN106109767A (en) * | 2016-07-13 | 2016-11-16 | 郑亮 | A kind of compound preparation preventing and treating non-alcohol fatty liver |
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Open date: 20100120 |