CN102526444A - Traditional Chinese medicine composition for invigorating kidney and strengthening yang and preparation method thereof - Google Patents
Traditional Chinese medicine composition for invigorating kidney and strengthening yang and preparation method thereof Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicine composition for invigorating the kidney and strengthening yang and a preparation method thereof. The traditional Chinese medicine composition is mainly prepared from traditional Chinese medicines including Chinese chive seed, epimedium, astragalus root, pseudo-ginseng and the like according to certain proportions by weight. The traditional Chinese medicine composition and proper pharmaceutical excipients can be prepared into any common oral preparation according to the conventional preparation processes. The traditional Chinese medicine composition provided by the invention has the functions of replenishing vitality and consolidating the constitution, invigorating the kidney and strengthening yang, promoting vital essence generation and invigorating qi as well as preventing diseases and prolonging the life. The clinical observation shows that the traditional Chinese medicine composition provided by the invention can be widely used for treating diseases such as sexual disorder and the like, and is also suitable for eliminating fatigue, delaying senility and strengthening physique.
Description
Invention field
The present invention relates to a kind of Chinese medicine composition of kidney invigorating and YANG supporting, relate in particular to and a kind ofly form Chinese medicine composition, belong to the field of Chinese medicines by pure Chinese medicines such as Semen Allii Tuberosi, Herba Epimedii, the Radix Astragali and Radix Notoginseng.
Background technology
Raising along with The development in society and economy and living standards of the people; People's live and work rhythm is obviously accelerated, and the pressure that is born is increasing, and especially the men's health level is on a declining curve year by year for many people; And occur suffering from a deficiency of the kidney, insufficiency of vital energy and blood etc.; Thereby cause the generation of many diseases, like the body alopecia, have a dizzy spell, disease such as sore waist and aching in the waist and the back, insomnia dysphoria with smothery sensation, and sexual disorder such as impotence and premature ejaculation, prostatosis.Because relevant knowledge lacks or the idea constraint, many people are ashamed of seeking medical advice and various analeptic on the abuse of market voluntarily, not only quicken the body health level decrease speed, also possibly bring out other serious diseases.
That sell or common in the market treatment is because the medicine of the above-mentioned disease that insufficiency of vital energy and blood causes has medicines such as whip ball, and like Pilulae Penis et testis cervi, three animal penes pill and various honeybee products etc., but all curative effect is not very definite, and expensive.In order to alleviate above-mentioned disease, the inventor is through great deal of experimental, will have the Herba Epimedii of kidney-replenishing, bone and muscle strengthening, the Semen Allii Tuberosi and the dissipating blood stasis hemostatic Radix Notoginseng of invigorating the liver and kidney controlling nocturnal emission with astringent drugs share; Mix the medical material of respectively distinguishing the flavor of of other the kidney invigorating and essence nourishing again, through clinical verification, the present composition has the effect of element culturing fixed folder, kidney invigorating and YANG supporting and spermatogenesis QI invigorating; Can be widely used in human body immunity improving power, defying age, kidney invigorating and YANG supporting etc.; Especially evident in efficacy to the symptoms such as sexual impotence, premature ejaculation and hyposexuality of kidney yang deficiency, not only drug effect is satisfactory, and price is relatively cheap many; Can substitute the above-mentioned product that gone on the market well, have very high market value and social benefit.
Summary of the invention
The object of the invention aims to provide a kind of have determined curative effect, the quality controllable Chinese medicine composition that has invigorating the liver and kidney, tonifying YANG controlling nocturnal emission with astringent drugs effect, is used for human body immunity improving power and sexual function improvement.
The objective of the invention is to realize through following manner:
Chinese medicine composition of the present invention is selected Semen Allii Tuberosi, Herba Epimedii, the Radix Astragali and Radix Notoginseng are made up, and the Semen Allii Tuberosi of wherein being selected for use sweet in the mouth warm in nature is hot, returns liver, kidney channel, the effect of tool temperature compensation Liver and kidney, tonifying YANG controlling nocturnal emission with astringent drugs; Herba Epimedii sweet in the mouth warm in nature is hot, the effect of tool kidney-replenishing, bone and muscle strengthening and wind-damp dispelling; And Radix Astragali slightly warm in nature sweet in the mouth is returned the liver,kidney,spleen warp, tool benefiting QI for strengthening the superficies, inducing diuresis to remove edema, and Radix Notoginseng sweet and slightly bitter taste warm in nature, the hemostasis of ability dissipating blood stasis, reducing swelling and alleviating pain, 45 usefulness can play the effect of temperature compensation Liver and kidney, tonifying YANG controlling nocturnal emission with astringent drugs.
In order to reach better therapeutic; The present composition also adds Cornu Cervi Pantotrichum, Radix Morindae Officinalis, Testis et Pentis Canis and Fructus Psoraleae in the above-mentioned raw materials medicine; Help the effect of Semen Allii Tuberosi and Herba Epimedii invigorating kidney-YANG, benefiting essence-blood altogether, and Radix Ginseng can strongly invigorating primordial QI, multiple arteries and veins takes off the effect that can help Radix Astragali QI invigorating to consolidate admittedly; Simultaneously again can promoting the production of body fluid and inducing sedation of the mind, so these article also have the effect of life prolonging.
In order to reach optimum curative effect, the present composition also adds the Scolopendra and the Cortex Eucommiae in the above-mentioned raw materials medicine.Wherein Scolopendra is flat puts out liver-fire, and the spasmolytic collateral dredging can help Radix Notoginseng collateral dredging dissipating blood stasis, and the Cortex Eucommiae also can invigorating the liver and kidney, coordinate all medicines, the effect of play element culturing fixed folder, kidney invigorating and YANG supporting, spermatogenesis QI invigorating altogether, preventing disease and prolonging life.Chinese medicine composition prescription of the present invention is rigorous, and temperature compensation is not dry, invigorating middle warmer has and rushes down, and strengthening body resistance and dispelling evil haves both at the same time, and all medicines complement each other, and can be widely used in sexual dysfunction and all diseases of going down.
Also to be the inventor through clinical treatment grope to sum up the consumption of each raw material components of Chinese medicine composition of the present invention draws, and each amounts of components is for all to have curative effect preferably to strengthening yang and invigorating kidney in the following weight parts scope:
Each component of Chinese medicine composition of the present invention and consumption are: 1～5 part of 1～10 part of Semen Allii Tuberosi, 4～12 parts of Herba Epimedii, 1～10 part of the Radix Astragali and Radix Notoginseng.
Further, each component of Chinese medicine composition of the present invention and consumption are: 1～10 part of 1～10 part of Semen Allii Tuberosi, 4～12 parts of Herba Epimedii, 1～10 part of the Radix Astragali, 1～5 part of Radix Notoginseng, 1～10 part in Cornu Cervi Pantotrichum, 1～10 part of Radix Morindae Officinalis, 1～10 part of Testis et Pentis Canis, 1～10 part of Fructus Psoraleae and Radix Ginseng.
Further, each component of Chinese medicine composition of the present invention and consumption are: 1～5 part of 1～10 part of Semen Allii Tuberosi, 4～12 parts of Herba Epimedii, 1～10 part of the Radix Astragali, 1～5 part of Radix Notoginseng, 1～10 part in Cornu Cervi Pantotrichum, 1～10 part of Radix Morindae Officinalis, 1～10 part of Testis et Pentis Canis, 1～10 part of Fructus Psoraleae, 1～10 part of Radix Ginseng, 2～10 parts of the Cortexs Eucommiae and Scolopendra.
Each amounts of components of Chinese medicine composition of the present invention is preferably: 2～3 parts of 3～8 parts of Semen Allii Tuberosi, 5～10 parts of Herba Epimedii, 3～8 parts of the Radixs Astragali, 2～4 parts of Radix Notoginseng, 3～8 parts in Cornu Cervi Pantotrichum, 3～8 parts of Radix Morindae Officinaliss, 3～8 parts of Testis et Pentis Canis, 3～8 parts of Fructus Psoraleaes, 3～8 parts of Radix Ginsengs, 4～7 parts of the Cortexs Eucommiae and Scolopendras.
Each amounts of components of Chinese medicine composition of the present invention most preferably is: 2.5 parts of 6 parts of Semen Allii Tuberosi, 8 parts of Herba Epimedii, 6 parts of the Radixs Astragali, 3 parts of Radix Notoginseng, 6 parts in Cornu Cervi Pantotrichum, 6 parts of Radix Morindae Officinaliss, 6 parts of Testis et Pentis Canis, 6 parts of Fructus Psoraleaes, 6 parts of Radix Ginsengs, 5 parts of the Cortexs Eucommiae and Scolopendras.
Another object of the present invention provides a kind of method for preparing of Chinese medicine composition of the present invention, brings into play curative effect better for each raw material that makes this medicine, and the present composition can take following method for preparing to obtain.But these can not be used to limit the protection domain of the present composition.
Said Chinese medicine composition can be prepared from following method for preparing:
A, Herba Epimedii is added water boil extract 1～3 time, each 0.5～3 hour, filter, merging filtrate is condensed into thick paste, adds a certain amount of alcohol and stirs, and leaves standstill, and gets supernatant, reclaims alcohol, and it is subsequent use to be concentrated into clear paste;
B, Semen Allii Tuberosi, Radix Notoginseng and the Radix Astragali are ground to form coarse powder, add alcohol percolation, collect percolate, reclaim alcohol; Be concentrated into clear paste, its medicinal residues add water boil and extract 1～3 time, each 0.5～3 hour, filter; Filtrating merges with percolate, is concentrated into clear paste, adds alcohol again and stirs, and leaves standstill; Get supernatant, reclaim alcohol, it is subsequent use to be concentrated into clear paste;
C, with A and B step gained clear paste mix homogeneously, concentrate drying promptly gets Chinese medicine composition effective ingredient of the present invention.
D, C is gone on foot gained Chinese medicine composition effective ingredient of the present invention add proper auxiliary materials and be prepared into corresponding pharmaceutical preparation.
Further, said Chinese medicine composition is prepared from following method for preparing:
A, Herba Epimedii is added water boil extract 1～3 time, each 0.5～3 hour, filter, merging filtrate is condensed into thick paste, adds a certain amount of alcohol and stirs, and leaves standstill, and gets supernatant, reclaims alcohol, and it is subsequent use to be concentrated into clear paste;
B, Cornu Cervi Pantotrichum and Radix Ginseng are ground to form coarse powder respectively, each adds alcohol percolation, collects percolate separately, reclaims alcohol and processes fluid extract;
C, Semen Allii Tuberosi, Radix Notoginseng, the Radix Astragali, Radix Morindae Officinalis, Fructus Psoraleae and Testis et Pentis Canis are ground to form coarse powder, add Cornu Cervi Pantotrichum and Radix Ginseng residue, add alcohol percolation, the collection percolate; Reclaim alcohol, be concentrated into clear paste, its medicinal residues add water boil and extract each 0.5～3 hour 1～3 time; Filter, filtrating is concentrated into clear paste with the percolate merging, adds alcohol again and stirs, and leaves standstill; Get supernatant, reclaim alcohol, it is subsequent use to be concentrated into clear paste;
D, with A and C step gained clear paste mix homogeneously, add B gained Cornu Cervi Pantotrichum fluid extract and ginseng liquid extract after the cooling again, mixing, concentrating under reduced pressure is dry, promptly gets Chinese medicine composition effective ingredient of the present invention.
E, the adjuvant that the adding of D gained mixture is suited are prepared into corresponding pharmaceutical preparation.
Further, Chinese medicine composition according to the invention is prepared from following method for preparing:
A, Herba Epimedii is added water boil extract 1～3 time, each 0.5～3 hour, filter, merging filtrate is condensed into thick paste, adds a certain amount of alcohol and stirs, and leaves standstill, and gets supernatant, reclaims alcohol, and it is subsequent use to be concentrated into clear paste;
B, Cornu Cervi Pantotrichum and Radix Ginseng are ground to form coarse powder respectively, each adds alcohol percolation, collects percolate separately, reclaims alcohol and processes fluid extract;
C, Semen Allii Tuberosi, Radix Notoginseng, the Radix Astragali, Radix Morindae Officinalis, Fructus Psoraleae, Testis et Pentis Canis, the Cortex Eucommiae and Scolopendra are ground to form coarse powder, add Cornu Cervi Pantotrichum and Radix Ginseng residue, add alcohol percolation, the collection percolate; Reclaim alcohol, be concentrated into clear paste, its medicinal residues add water boil and extract each 0.5～3 hour 1～3 time; Filter, filtrating is concentrated into clear paste with the percolate merging, adds alcohol again and stirs, and leaves standstill; Get supernatant, reclaim alcohol, it is subsequent use to be concentrated into clear paste;
D, with A and C step gained clear paste mix homogeneously, add B gained Cornu Cervi Pantotrichum fluid extract and ginseng liquid extract after the cooling again, mixing, concentrating under reduced pressure is dry, promptly gets Chinese medicine composition effective ingredient of the present invention.
E, the adjuvant that the adding of D gained mixture is suited are prepared into corresponding pharmaceutical preparation.
The present composition can adopt the conventional method of Chinese medicine preparation to be prepared into any conventional formulation; The active component that is about to the medicine of the present invention of gained adds various conventional adjuvant required when preparing different dosage form; Like disintegrating agent, lubricant, binding agent etc.; Method of Chinese medicinal with routine is prepared into corresponding preparations, comprises any modern preparation that allows on the pharmaceuticss such as injection type, peroral dosage form, percutaneous dosing dosage form, mucosa absorption dosage form.
Chinese medicine composition oral liquid of the present invention is prepared from following method:
A, take by weighing each component by weight: 2.5 parts of 6 parts of Semen Allii Tuberosi, 8 parts of Herba Epimedii, 6 parts of the Radixs Astragali, 3 parts of Radix Notoginseng, 6 parts in Cornu Cervi Pantotrichum, 6 parts of Radix Morindae Officinaliss, 6 parts of Testis et Pentis Canis, 6 parts of Fructus Psoraleaes, 6 parts of Radix Ginsengs, 5 parts of the Cortexs Eucommiae and Scolopendras.
B, Herba Epimedii is added water boil extract 2 times, 2 hours for the first time, 1.5 hours for the second time, filter; Merging filtrate, being condensed into the crude drug amount is the 2g/ml stiff paste, the ethanol that adds the suitable concentration of 2 times of amounts stirs, and leaves standstill 48 hours; Get supernatant, reclaim ethanol, it is subsequent use to be concentrated into clear paste;
C, Cornu Cervi Pantotrichum and Radix Ginseng are ground to form coarse powder respectively, each adds alcohol percolation, collects percolate separately, reclaims alcohol and processes fluid extract;
D, Semen Allii Tuberosi, Radix Notoginseng, the Radix Astragali, Radix Morindae Officinalis, Fructus Psoraleae, Testis et Pentis Canis, the Cortex Eucommiae and Scolopendra are ground to form coarse powder, add Cornu Cervi Pantotrichum and Radix Ginseng residue, add alcohol percolation, the collection percolate; Reclaim alcohol, be concentrated into clear paste, each medicinal residues adds water boil and extracts 2 times, 2 hours for the first time; 1 hour for the second time, filter, filtrating is concentrated into clear paste with the percolate merging, and the ethanol that adds qdx again stirs; Left standstill 48 hours, and got supernatant, reclaim alcohol, it is subsequent use to be concentrated into clear paste;
E, with B and D step gained clear paste mix homogeneously, add C gained Cornu Cervi Pantotrichum fluid extract and ginseng liquid extract after the cooling again, mixing promptly gets Chinese medicine composition effective ingredient of the present invention.
F, E gained mixture is added sucrose and an amount of antiseptic is prepared into oral liquid by the conventional method for preparing of oral liquid.
The effect that Chinese medicine composition of the present invention has element culturing fixed folder, kidney invigorating and YANG supporting, spermatogenesis QI invigorating, prevents disease and prolongs life; Clinical observation shows that Chinese medicine composition of the present invention can be widely used in diseases such as therapeutic dysfunction, also is applicable to allaying tiredness, slow down aging and health invigorating.
The oral effective daily dose of the present invention is 4～25g raw medicinal herbs, divides and takes for 1～3 time.
The pharmacodynamic study of Test Example 1, Chinese medicine composition kidney invigorating and YANG supporting of the present invention and immunostimulant
One, test medicament
The homemade Chinese medicine composition 1 of the present invention of the applicant is (by the Semen Allii Tuberosi of certain part by weight composition; Herba Epimedii; The effective ingredient that the Radix Astragali and Radix Notoginseng obtain through method for preparing of the present invention); Chinese medicine composition 2 of the present invention is (by the Semen Allii Tuberosi of certain part by weight composition; Herba Epimedii; The Radix Astragali; Radix Notoginseng; Cornu Cervi Pantotrichum; Radix Morindae Officinalis; Testis et Pentis Canis; The effective ingredient that Fructus Psoraleae and Radix Ginseng obtain through method for preparing of the present invention); Chinese medicine composition 3 of the present invention is (by the Semen Allii Tuberosi of certain part by weight composition; Herba Epimedii; The Radix Astragali; Radix Notoginseng; Cornu Cervi Pantotrichum; Radix Morindae Officinalis; Testis et Pentis Canis; Fructus Psoraleae; Radix Ginseng; The effective ingredient that the Scolopendra and the Cortex Eucommiae obtain through method for preparing of the present invention); JINGUI SHENQI WAN, the Beijing Tongrentang Technology Development Co.ltd. Pharmaceutical Factory produces.
Two, laboratory animal
NIH is a mice, and the SD rat is provided by Hu'nan Inst. of Plarmaceutical Industry.
Three, method and result
1, to the influence of teenage levels of serum testosterone level
Choose 50 of healthy male rats, body weight is 110 ± 10g, is divided into 5 groups at random, respectively gastric infusion; Once a day, continuous 12 days, fasting was 12 hours after the last administration; With 0.6% pentobarbital sodium intraperitoneal injection of anesthesia, the heart extracting blood separation of serum is used the serum measured by radioimmunoassay testosterone levels.The result sees table 1 as follows:
Table 1 Chinese medicine composition of the present invention is to the influence of immaturity levels of serum testosterone level (x ± s)
| Group | Number of animals (only) | Dosage (g/kg) | Serum testosterone (nmol/L) |
| The blank group | 10 | —— | 0.47±0.21 |
| Pieces of Jin ' gui shenqi is precious | 10 | 2.00 | 1.72±0.38** |
| The present composition 1 | 10 | 1.25 | 1.70±0.76** |
| The present composition 1 | 10 | 1.25 | 2.05±0.69** |
| The present composition 1 | 10 | 1.20 | 2.43±0.58** |
Compare with the blank group: * * P＜0.01
Visible by last table result, Chinese medicine composition of the present invention can improve immaturity male white rat level of serum testosterone, compares with the blank group, and difference has highly significant property, compares with the pieces of Jin ' gui shenqi treasured, and effect has superiority.
2, to the influence of insufficiency of kidney-YANG animal
Choose 60 of healthy male white mice, body weight is 20 ± 5g, gastric infusion after the random packet, and while subcutaneous injection hydrocortisone 25mg/kg, normal group gives the equivalent normal saline, every day 1 time, continuous 9 days.Put to death after taking by weighing the mice body weight on the 10th day, cut open and get adrenal gland, thymus, spleen, preputial glands and testis, prostate and seminal fluid capsule, precision is weighed, and calculates organ index.The result sees the following form 2, table 3:
Table 2, medicine of the present invention are to the influence of insufficiency of kidney-YANG mice body weight, adrenal gland, thymus and spleen (x ± s)
| Group | Number of animals (only) | Dosage (g/kg) | Body weight (g) | Adrenal gland (mg/10g) | Thymus (mg/10g) | Spleen (mg/10g) |
| The blank group | 10 | —— | 7.32±1.05** | 3.85±0.84** | 23.97±5.64** | 86.21±28.64** |
| Hydrogen can+distilled water | 10 | —— | 2.04±0.98 | 2.06±0.42 | 11.98±3.65 | 37.12±9.12 |
| Shenqi pill | 10 | 2.00 | 5.97±0.87** | 2.81±0.69** | 17.82±1.51 | 48.31±10.18 |
| The present composition 1 | 10 | 1.25 | 4.10±1.23** | 2.60±0.54** | 14.97±3.12** | 43.38±12.06** |
| The present composition 2 | 10 | 1.25 | 5.01±1.41** | 2.41±0.58** | 15.34±2.67** | 46.87±9.28** |
| The present composition 3 | 10 | 1.20 | 6.54±1.15** | 3.15±0.67** | 18.54±3.58** | 50.69±10.36** |
(**P＜0.01)
Above result shows; Normal mouse after 9 days weight average increased 7.32g; Model of yang asthenia white mice body weight due to the hydrocortisone obviously alleviates (P＜0.01); And each prescription of the present composition all can prevent weight loss, with hydrogen can+distilled water group comparing difference has highly significant property meaning (P＜0.01), effect and pieces of Jin ' gui shenqi treasured are quite or stronger; And the present invention can prevent the mice atrophy of adrenal gland due to the hydrocortisone, with hydrogen can+distilled water group comparing difference has highly significant property meaning (P＜0.01).
Table 3, medicine of the present invention are to insufficiency of kidney-YANG mice accessory sex organ's influence (x ± s)
| Group | Number of animals (only) | Dosage (g/kg) | Testis (mg/10g) | Prostate and seminal fluid capsule (mg/10g) | Preputial glands (mg/10g) |
| The blank group | 10 | —— | 60.54±8.23 | 62.03±10.26** | 8.21±1.69** |
| Hydrogen can+distilled water | 10 | —— | 58.64±7.68 | 25.68±12.64 | 4.31±1.23 |
| Hydrogen can+kidney qi is precious | 10 | 2.00 | 60.35±6.95 | 43.29±11.31** | 6.05±1.32** |
| Hydrogen can+present composition 1 | 10 | 1.25 | 60.54±7.26 | 40.87±9.68** | 5.97±1.36 |
| Hydrogen can+present composition 2 | 10 | 1.25 | 62.34±6.35 | 44.10±12.11** | 6.11±2.06** |
| Hydrogen can+present composition 3 | 10 | 1.20 | 65.13±10.47 | 48.43±10.52** | 7.60±1.68** |
Hydrocortisone can cause male white mouse accessory sex organ atrophy; The result of table 5 shows; The present invention can prevent prostate and the atrophy of seminal fluid capsule, with hydrogen can-the distilled water group relatively, the difference (P＜0.01) of highly significant property is arranged; Simultaneously the present composition can also prevent the preputial glands atrophy, and effect than the kidney qi treasured by force or stronger.
In sum, Chinese medicine composition of the present invention has the effect of kidney invigorating and YANG supporting, and effect is better than the kidney qi treasured.
The specific embodiment
Below come further to set forth present composition and preparation method thereof through embodiment.
Embodiment 1, tablet of the present invention
Take by weighing Semen Allii Tuberosi 1600g, Herba Epimedii 1900g, Radix Astragali 1600g and Radix Notoginseng 800g, Herba Epimedii is added water boil extract 2 times, 3 hours for the first time; 1 hour for the second time, filter merging filtrate; Be condensed into thick paste, the ethanol that adds 3 times of amounts 90% stirs, and leaves standstill 24 hours; Get supernatant, reclaim ethanol, it is subsequent use to be concentrated into clear paste; Semen Allii Tuberosi, Radix Notoginseng and the Radix Astragali are ground to form coarse powder, add 50% ethanol percolation, collect percolate, reclaim ethanol, be concentrated into clear paste; Its medicinal residues add water boil and extract 2 times, each each 2 hours, filter merging filtrate; And merge with percolate and to be concentrated into clear paste, add ethanol again and stir, left standstill 24 hours, get supernatant; Reclaim ethanol, be concentrated into behind the clear paste and Herba Epimedii clear paste mix homogeneously, concentrate drying adds suitable additive of tablet and is prepared into 1000 in tablet.
Embodiment 2, capsule of the present invention
Take by weighing Semen Allii Tuberosi 1000g, Herba Epimedii 800g, Radix Astragali 1000g, Radix Notoginseng 200g, Cornu Cervi Pantotrichum 200g, Radix Morindae Officinalis 2000g, Testis et Pentis Canis 200g, Fructus Psoraleae 1000g and Radix Ginseng 1000g, Herba Epimedii is added water boil extracted 3 hours, filter; Be condensed into thick paste; 95% ethanol that adds 2 times of amounts stirs, and leaves standstill 48 hours, gets supernatant; Reclaim ethanol, it is subsequent use to be concentrated into clear paste; Cornu Cervi Pantotrichum and Radix Ginseng are ground to form coarse powder respectively, and each adds 50% ethanol percolation, collects percolate separately, reclaims alcohol and processes fluid extract; Semen Allii Tuberosi, Radix Notoginseng, the Radix Astragali, Radix Morindae Officinalis, Fructus Psoraleae and Testis et Pentis Canis are ground to form coarse powder, add Cornu Cervi Pantotrichum and Radix Ginseng residue, add 65% ethanol percolation, collect percolate; Reclaim alcohol, be concentrated into clear paste, its medicinal residues add water boil and extract 3 times, each each 1 hour; Filter, filtrating is concentrated into clear paste with the percolate merging, adds ethanol again and stirs, and leaves standstill 24 hours; Get supernatant, reclaim alcohol, be concentrated into clear paste and with Herba Epimedii clear paste mix homogeneously, add Cornu Cervi Pantotrichum and ginseng liquid extract after the cooling again; Mixing, concentrating under reduced pressure is dry, gains is added suitable capsule adjuvant be prepared into 1000 of capsules.
Embodiment 3, oral liquid of the present invention
Take by weighing Semen Allii Tuberosi 100g, Herba Epimedii 130g, Radix Astragali 100g, Radix Notoginseng 50g, Cornu Cervi Pantotrichum 100g, Radix Morindae Officinalis 100g, Testis et Pentis Canis 100g, Fructus Psoraleae 100g, Radix Ginseng 100g, Cortex Eucommiae 800g and Scolopendra 400g; Herba Epimedii is added water boil extract 2 times, 2 hours for the first time, 1.5 hours for the second time, filter, merging filtrate, being condensed into the crude drug amount is the 2g/ml stiff paste, and 95% the ethanol that adds 2 times of amounts stirs, and leaves standstill 48 hours, gets supernatant, reclaims ethanol, and it is subsequent use to be concentrated into clear paste; Cornu Cervi Pantotrichum and Radix Ginseng are ground to form coarse powder respectively, and each adds 60% ethanol percolation, collects percolate separately, reclaims alcohol and processes fluid extract; Semen Allii Tuberosi, Radix Notoginseng, the Radix Astragali, Radix Morindae Officinalis, Fructus Psoraleae, Testis et Pentis Canis, the Cortex Eucommiae and Scolopendra are ground to form coarse powder, add Cornu Cervi Pantotrichum and Radix Ginseng residue, add 60% ethanol percolation, collect percolate, reclaim alcohol; Be concentrated into clear paste, each medicinal residues adds water boil and extracts 2 times, 2 hours for the first time, 1 hour for the second time, filters; Filtrating is concentrated into clear paste with the percolate merging, and the ethanol that adds qdx again stirs, and leaves standstill 48 hours, gets supernatant; Reclaim alcohol, be concentrated into clear paste, again with Herba Epimedii clear paste mix homogeneously, cooling; Add Cornu Cervi Pantotrichum fluid extract and ginseng liquid extract again, mixing, oral liquid adjuvants such as adding essence add water to 2000ml again, stir; Filter, leave standstill, fill, sterilization promptly gets 100 of Chinese medicine oral liquid of the present invention.
Embodiment 4, pellet capsule of the present invention
Take by weighing Semen Allii Tuberosi 800g, Herba Epimedii 500g, Radix Astragali 800g, Radix Notoginseng 200g, Cornu Cervi Pantotrichum 300g, Radix Morindae Officinalis 800g, Testis et Pentis Canis 300g, Fructus Psoraleae 300g, Radix Ginseng 300g, Cortex Eucommiae 400g and Scolopendra 300g, Herba Epimedii is added water boil extract each 1.5 hours 2 times; Filter, merging filtrate, being condensed into the crude drug amount is the 2g/ml stiff paste; The ethanol that adds equivalent 90% stirs, and leaves standstill 24 hours, gets supernatant; Reclaim ethanol, it is subsequent use to be concentrated into clear paste; Cornu Cervi Pantotrichum and Radix Ginseng are ground to form coarse powder respectively, and each adds 50% ethanol percolation, collects percolate separately, reclaims alcohol and processes fluid extract; Semen Allii Tuberosi, Radix Notoginseng, the Radix Astragali, Radix Morindae Officinalis, Fructus Psoraleae, Testis et Pentis Canis, the Cortex Eucommiae and Scolopendra are ground to form coarse powder, add Cornu Cervi Pantotrichum and Radix Ginseng residue, add 50% ethanol percolation, collect percolate, reclaim alcohol; Be concentrated into clear paste, each medicinal residues adds water boil and extracts 3 times, each each 1 hour, filters; Filtrating is concentrated into clear paste with the percolate merging, and the ethanol that adds equivalent again stirs, and leaves standstill 24 hours, gets supernatant; Reclaim alcohol, be concentrated into clear paste, again with Herba Epimedii clear paste mix homogeneously, cooling; Add Cornu Cervi Pantotrichum fluid extract and ginseng liquid extract again, mixing adds suitable an amount of pellet capsule adjuvant, is prepared into 1000 of pellt capsules according to conventional method.
Embodiment 5, oral liquid of the present invention
Take by weighing Semen Allii Tuberosi 100g, Herba Epimedii 130g, Radix Astragali 100g, Radix Notoginseng 50g, Cornu Cervi Pantotrichum 100g, Radix Morindae Officinalis 100g, Testis et Pentis Canis 100g, Fructus Psoraleae 100g, Radix Ginseng 100g, Cortex Eucommiae 800g and Scolopendra 400g; Herba Epimedii is added water boil extract 3 times, each 1.5 hours, filter, merging filtrate, being condensed into the crude drug amount is the 1.8g/ml stiff paste, and 90% the ethanol that adds 3 times of amounts stirs, and leaves standstill 24 hours, gets supernatant, reclaims ethanol, and it is subsequent use to be concentrated into clear paste; Cornu Cervi Pantotrichum and Radix Ginseng are ground to form coarse powder respectively, and each adds 55% ethanol percolation, collects percolate separately, reclaims alcohol and processes fluid extract; Semen Allii Tuberosi, Radix Notoginseng, the Radix Astragali, Radix Morindae Officinalis, Fructus Psoraleae, Testis et Pentis Canis, the Cortex Eucommiae and Scolopendra are ground to form coarse powder, add Cornu Cervi Pantotrichum and Radix Ginseng residue, add 55% ethanol percolation, collect percolate, reclaim alcohol; Be concentrated into clear paste, each medicinal residues adds water boil and extracts 3 times, 1 hour for the first time, the second time and the 2nd time each 2 hours, filters; Filtrating is concentrated into clear paste with the percolate merging, and the ethanol that adds 3 times of amounts again stirs, and leaves standstill 24 hours, gets supernatant; Reclaim alcohol, be concentrated into clear paste, again with Herba Epimedii clear paste mix homogeneously, cooling; Add Cornu Cervi Pantotrichum fluid extract and ginseng liquid extract again, mixing adds suitable for oral administration liquid adjuvant and adds water to 2000ml again, stirs; Filter, leave standstill, fill, sterilization promptly gets 100 of Chinese medicine oral liquid of the present invention.
Embodiment 6, granule of the present invention
Take by weighing Semen Allii Tuberosi 500g, Herba Epimedii 400g, Radix Astragali 500g and Radix Notoginseng 200g, Herba Epimedii is added water boil extracted 3 hours, filter, be condensed into thick paste, the ethanol that adds 2 times of amounts 95% stirs, and leaves standstill 36 hours, gets supernatant, reclaims ethanol, and it is subsequent use to be concentrated into clear paste; Semen Allii Tuberosi, Radix Notoginseng and the Radix Astragali are ground to form coarse powder, add 65% ethanol percolation, collect percolate, reclaim ethanol, be concentrated into clear paste; Its medicinal residues add water boil and extract 3 times, each each 1.5 hours, filter merging filtrate; And merge with percolate and to be concentrated into clear paste, the ethanol that adds 3 times of amounts again stirs, and leaves standstill 36 hours, gets supernatant; Reclaim ethanol, be concentrated into behind the clear paste and Herba Epimedii clear paste mix homogeneously, concentrating under reduced pressure is dry, adds suitable granule adjuvant and is prepared into granule 500 bags.
Embodiment 7, oral liquid of the present invention
Take by weighing Semen Allii Tuberosi 120g, Herba Epimedii 1200g, Radix Astragali 360g, Radix Notoginseng 480g, Cornu Cervi Pantotrichum 960g, Radix Morindae Officinalis 360g, Testis et Pentis Canis 960g, Fructus Psoraleae 960g and Radix Ginseng 1200g, Herba Epimedii is added water boil extract 2 times, each each 3 hours; Filter, be condensed into thick paste, 95% ethanol that adds 2 times of amounts stirs; Left standstill 24 hours; Get supernatant, reclaim ethanol, it is subsequent use to be concentrated into clear paste; Cornu Cervi Pantotrichum and Radix Ginseng are ground to form coarse powder respectively, and each adds 55% ethanol percolation, collects percolate separately, reclaims alcohol and processes fluid extract; Semen Allii Tuberosi, Radix Notoginseng, the Radix Astragali, Radix Morindae Officinalis, Fructus Psoraleae and Testis et Pentis Canis are ground to form coarse powder, add Cornu Cervi Pantotrichum and Radix Ginseng residue, add 55% ethanol percolation, collect percolate, reclaim alcohol; Be concentrated into clear paste, its medicinal residues add water boil and extracted 2 hours, filter, and filtrating is concentrated into clear paste with the percolate merging; Add ethanol again and stir, left standstill 24 hours, get supernatant, reclaim alcohol; Be concentrated into clear paste and with Herba Epimedii clear paste mix homogeneously, add Cornu Cervi Pantotrichum and ginseng liquid extract after the cooling again, mixing, add suitable oral liquid adjuvant after the adjustment total amount to 1000ml; Filter, leave standstill, fill, sterilization promptly gets 100 of oral liquids of the present invention.
Claims (10)
1. the Chinese medicine composition of a kidney invigorating and YANG supporting is characterized in that each crude drug by following weight parts: 1～5 part of 1～10 part of Semen Allii Tuberosi, 4～12 parts of Herba Epimedii, 1～10 part of the Radix Astragali and Radix Notoginseng are formed with the pharmacy acceptable auxiliary.
2. Chinese medicine composition according to claim 1 is characterized in that said Chinese medicine composition is prepared from following method for preparing:
A, Herba Epimedii is added water boil extract 1～3 time, each 0.5～3 hour, filter, merging filtrate is condensed into thick paste, adds a certain amount of alcohol and stirs, and leaves standstill, and gets supernatant, reclaims alcohol, and it is subsequent use to be concentrated into clear paste;
B, Semen Allii Tuberosi, Radix Notoginseng and the Radix Astragali are ground to form coarse powder, add alcohol percolation, collect percolate, reclaim alcohol; Be concentrated into clear paste, its medicinal residues add water boil and extract 1～3 time, each 0.5～3 hour, filter; Filtrating is concentrated into clear paste with the percolate merging, adds alcohol again and stirs, and leaves standstill; Get supernatant, reclaim alcohol, it is subsequent use to be concentrated into clear paste;
C, with A and B step gained clear paste mix homogeneously, concentrate drying promptly gets Chinese medicine composition effective ingredient of the present invention.
D, C is gone on foot gained Chinese medicine composition effective ingredient of the present invention add proper auxiliary materials and be prepared into corresponding pharmaceutical preparation.
3. Chinese medicine composition according to claim 1 is characterized in that said Chinese medicine composition also has each crude drug of following weight portion: 1～10 part of 1～10 part in Cornu Cervi Pantotrichum, 1～10 part of Radix Morindae Officinalis, 1～10 part of Testis et Pentis Canis, 1～10 part of Fructus Psoraleae and Radix Ginseng.
4. Chinese medicine composition according to claim 3 is characterized in that said Chinese medicine composition is prepared from following method for preparing:
A, Herba Epimedii is added water boil extract 1～3 time, each 0.5～3 hour, filter, merging filtrate is condensed into thick paste, adds a certain amount of alcohol and stirs, and leaves standstill, and gets supernatant, reclaims alcohol, and it is subsequent use to be concentrated into clear paste;
B, Cornu Cervi Pantotrichum and Radix Ginseng are ground to form coarse powder respectively, each adds alcohol percolation, collects percolate separately, reclaims alcohol and processes fluid extract;
C, Semen Allii Tuberosi, Radix Notoginseng, the Radix Astragali, Radix Morindae Officinalis, Fructus Psoraleae and Testis et Pentis Canis are ground to form coarse powder, add Cornu Cervi Pantotrichum and Radix Ginseng residue, add alcohol percolation, the collection percolate; Reclaim alcohol, be concentrated into clear paste, its medicinal residues add water boil and extract each 0.5～3 hour 1～3 time; Filter, filtrating is concentrated into clear paste with the percolate merging, adds alcohol again and stirs, and leaves standstill; Get supernatant, reclaim alcohol, it is subsequent use to be concentrated into clear paste;
D, with A and C step gained clear paste mix homogeneously, add B gained Cornu Cervi Pantotrichum fluid extract and ginseng liquid extract after the cooling again, mixing, concentrating under reduced pressure is dry, promptly gets Chinese medicine composition effective ingredient of the present invention.
E, the adjuvant that the adding of D gained mixture is suited are prepared into corresponding pharmaceutical preparation.
5. Chinese medicine composition according to claim 1 is characterized in that said Chinese medicine composition also has each raw material of following weight portion: 1～5 part of 2～10 parts of the Cortexs Eucommiae and Scolopendra.
6. Chinese medicine composition according to claim 5 is characterized in that said Chinese medicine composition is prepared from following method for preparing:
A, Herba Epimedii is added water boil extract 1～3 time, each 0.5～3 hour, filter, merging filtrate is condensed into thick paste, adds a certain amount of alcohol and stirs, and leaves standstill, and gets supernatant, reclaims alcohol, and it is subsequent use to be concentrated into clear paste;
B, Cornu Cervi Pantotrichum and Radix Ginseng are ground to form coarse powder respectively, each adds alcohol percolation, collects percolate separately, reclaims alcohol and processes fluid extract;
C, Semen Allii Tuberosi, Radix Notoginseng, the Radix Astragali, Radix Morindae Officinalis, Fructus Psoraleae, Testis et Pentis Canis, the Cortex Eucommiae and Scolopendra are ground to form coarse powder, add Cornu Cervi Pantotrichum and Radix Ginseng residue, add alcohol percolation, the collection percolate; Reclaim alcohol, be concentrated into clear paste, its medicinal residues add water boil and extract each 0.5～3 hour 1～3 time; Filter, filtrating is concentrated into clear paste with the percolate merging, adds alcohol again and stirs, and leaves standstill; Get supernatant, reclaim alcohol, it is subsequent use to be concentrated into clear paste;
D, with A and C step gained clear paste mix homogeneously, add B gained Cornu Cervi Pantotrichum fluid extract and ginseng liquid extract after the cooling again, mixing, concentrating under reduced pressure is dry, promptly gets Chinese medicine composition effective ingredient of the present invention.
E, the adjuvant that the adding of D gained mixture is suited are prepared into corresponding pharmaceutical preparation.
7. Chinese medicine composition according to claim 1 is characterized in that said Chinese medicine composition each crude drug by following weight parts: 3～8 parts of Semen Allii Tuberosi, 5～10 parts of Herba Epimedii, 3～8 parts of the Radixs Astragali, 2～4 parts of Radix Notoginseng, 3～8 parts in Cornu Cervi Pantotrichum, 3～8 parts of Radix Morindae Officinaliss, 3～8 parts of Testis et Pentis Canis, 3～8 parts of Fructus Psoraleaes, 3～8 parts of Radix Ginsengs, 4～7 parts of the Cortexs Eucommiae and 2～3 parts of Scolopendras and pharmacy acceptable auxiliary are formed.
8. Chinese medicine composition according to claim 1 is characterized in that said Chinese medicine composition each crude drug by following weight parts: 6 parts of Semen Allii Tuberosi, 8 parts of Herba Epimedii, 6 parts of the Radixs Astragali, 3 parts of Radix Notoginseng, 6 parts in Cornu Cervi Pantotrichum, 6 parts of Radix Morindae Officinaliss, 6 parts of Testis et Pentis Canis, 6 parts of Fructus Psoraleaes, 6 parts of Radix Ginsengs, 5 parts of the Cortexs Eucommiae and 2.5 parts of Scolopendras and pharmacy acceptable auxiliary are formed.
9. according to each described Chinese medicine composition of claim 1～8, it is characterized in that said Chinese medicine composition is any modern preparation that allows on the pharmaceutics, comprises peroral dosage form, injection type and transdermal dosage form, especially cataplasma.
10. Chinese medicine composition according to claim 9 is characterized in that said Chinese medicine composition is used to be prepared into the pharmaceutical preparation of kidney invigorating and YANG supporting.
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| CN104027493A (en) * | 2014-05-26 | 2014-09-10 | 陆华 | Pharmaceutical composition for preventing or treating yang deficiency syndrome and preparation method and application of pharmaceutical composition |
| CN104397700A (en) * | 2014-12-09 | 2015-03-11 | 广东省医药保健品进出口公司 | Functional health product for relieving physical fatigue and preparation method of functional health product |
| CN112933181A (en) * | 2021-02-05 | 2021-06-11 | 老君堂生物科技有限公司 | Kidney tonifying pill and preparation method thereof |
| CN117503833A (en) * | 2023-11-01 | 2024-02-06 | 吉林省君美生物科技有限公司 | A Chinese medicinal composition with yang supporting and kidney invigorating effects, and its preparation method |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104027493A (en) * | 2014-05-26 | 2014-09-10 | 陆华 | Pharmaceutical composition for preventing or treating yang deficiency syndrome and preparation method and application of pharmaceutical composition |
| CN104397700A (en) * | 2014-12-09 | 2015-03-11 | 广东省医药保健品进出口公司 | Functional health product for relieving physical fatigue and preparation method of functional health product |
| CN112933181A (en) * | 2021-02-05 | 2021-06-11 | 老君堂生物科技有限公司 | Kidney tonifying pill and preparation method thereof |
| CN117503833A (en) * | 2023-11-01 | 2024-02-06 | 吉林省君美生物科技有限公司 | A Chinese medicinal composition with yang supporting and kidney invigorating effects, and its preparation method |
| CN117503833B (en) * | 2023-11-01 | 2024-04-30 | 吉林省君美生物科技有限公司 | A Chinese medicinal composition with yang supporting and kidney invigorating effects, and its preparation method |
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Address after: 410008, Hunan, Changsha province Furong South Road section 368 BOBO world city CTA wealth center, 24 floor Applicant after: HUNAN JIUDIAN PHARMACEUTICAL CO., LTD. Address before: 410008, Hunan, Changsha province Furong South Road section 368 BOBO world city CTA wealth center, 24 floor Applicant before: Hunan Jiudian Pharmaceutical Co., Ltd. |
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Application publication date: 20120704 |