CN102058673B - Chinese medicine composition for expelling wind and removing dampness and preparation method thereof - Google Patents
Chinese medicine composition for expelling wind and removing dampness and preparation method thereof Download PDFInfo
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Abstract
The invention provides a Chinese medicine composition for expelling wind and removing dampness and a preparation method thereof. The composition is mainly prepared from Chinese medicines such as herba pyrolae, pangolin, south slender acanthopanax, ramulus mori, and the like in a certain weight ratio. The composition can be prepared into dosage forms of any frequently-used oral preparation with proper medicinal auxiliary materials according to a conventional preparation process. The Chinese medicine composition has the effects of expelling wind and removing dampness, and proved by clinical observation, the Chinese medicine composition can be widely applied to treating diseases of rheumatism, scapulohumeral periarthritis, and the like.
Description
Invention field
The present invention relates to a kind of Chinese medicine composition of expelling wind and removing dampness, relate in particular to and a kind ofly form Chinese medicine composition, belong to the field of Chinese medicines by pure Chinese medicines such as Herba Pyrolae, big gun first and south Acanthopanax gracilistylus.
Background technology
Rheumatism or rheumatoid arthritis are a kind ofly clinically common to be changed to main systemic disease with the joint; Its main pathological change has that the joint is oozed out, lymphocytic infiltration and synovium of joint hypertrophy; It is a kind of chronic inflammatory disease process of outbreak repeatedly; Belong to autoimmune disease, maybe be relevant with multiple factors such as infection, heredity and disorders of immune mechanism.This disease is about 0.3～1% at the sickness rate of China.
At present to the treatment of this disease mainly adopting Drug therapy aspect the doctor trained in Western medicine, like NSAID, though this type medicine can alleviate clinical symptoms and sign, but can not effect a radical cure inflammation, thereby can not prevent tissue injury, destruction of joint and deformity.And China adopts Chinese medicine to obtain good effect all the time.
Traditional Chinese medical theory thinks that " rheumatism " is " strongly fragrant " card; Belong to " arthralgia aggravated by cold " disease category, it is to cause the stagnation of QI-blood main cause that susceptible to anger is worried, and also is that QI and bloodization is living handicapped basic; " wind and cold is wet " evil steroid does not for a long time loose; Invasion and attack are directly gone into internal organs " spleen kidney " in the body, and the traditional Chinese medical science thinks that this disease is outer and joint swelling and pain, and interior and biochemical function descends and declines partially with the inclined to one side Sheng of QI and blood so that at the generation of disease.So the applicant is on this basis; With the Herba Pyrolae is monarch drug; Big gun first and Ramulus Mori etc. have ingenious the combining of each medical material of expelling wind and removing dampness; Through clinical research confirmation, Chinese medicine composition of the present invention curative effect aspect diseases such as treatment rheumatism or rheumatoid arthritis is satisfactory, has good social benefit and clinical value.
Summary of the invention
The object of the invention aims to provide a kind of Chinese medicine composition with diseases such as determined curative effect, quality controllable treatment rheumatism, rheumatoids.
The objective of the invention is to realize through following manner:
Chinese medicine composition of the present invention is selected Herba Pyrolae, big gun first, south Acanthopanax gracilistylus and Ramulus Mori are made up, and the Herba Pyrolae of wherein being selected for use sweet-bitter flavor warm in nature is gone into liver, kidney two warps, ability the kidney invigorating bone strengthening, expelling wind and removing dampness; Big gun first cold nature distinguishes the flavor of, and returns liver, stomach warp, the eliminating carbuncle of invigorating blood circulation, the damp eliminating of promoting blood circulation; Ramulus Mori property is equalled sweet in the mouth, suffering, wind-damp dispelling, qualcomm meridian, row aqueous vapor; South Acanthopanax gracilistylus also has diffusing wind damp eliminating, the effect of inducing diuresis to remove edema and liver and kidney tonifying strengthening bone and muscle, and four compatibilities can produce good synergism, can play effects such as dispersing swelling and dissipating binds, expelling wind and removing dampness altogether, thereby effectively prevent and treat the strongly fragrant disease of arthralgia aggravated by cold disease.
In order to reach better therapeutic; The present composition also adds the Radix Salviae Miltiorrhizae of promoting blood circulation to remove blood stasis in the above-mentioned raw materials medicine; The Radix Gentianae Macrophyllae of wind-damp dispelling, clearind deficient heat and the Fructus Chaenomelis of relaxing muscles and tendons and activating QI and blood in the collateral; Not only can help Herba Pyrolae and Ramulus Mori wind-damp dispelling, qualcomm meridian, blood stasis alive, also can help south Acanthopanax gracilistylus and big gun first the kidney invigorating bone strengthening, dispersing swelling and dissipating binds.
In order to reach optimum curative effect, the present composition also adds Radix Angelicae Sinensis, Rhizoma Corydalis, Scorpio and Radix Astragali, the effect of playing expelling wind and removing dampness, promoting blood circulation to remove obstruction in the collateral and the kidney invigorating bone strengthening altogether in the above-mentioned raw materials medicine.
Also to be the inventor through clinical treatment grope to sum up the consumption of each raw material components of Chinese medicine composition of the present invention draws, and each amounts of components is for all having curative effect preferably to treatment like arthralgia aggravated by cold diseases such as rheumatic arthritis and scapulohumeral periarthritis in the following weight parts scope:
10～80 parts of 10～80 parts of Herba Pyrolaes, 5～45 parts of big gun first, 5～20 parts of south Acanthopanax gracilistylus and Ramulus Moris;
Be preferably 5～45 parts of 10～80 parts of Herba Pyrolaes, 5～45 parts of big gun first, 5～20 parts of south Acanthopanax gracilistylus, 10～80 parts of Ramulus Moris, 10～80 parts of Radix Salviae Miltiorrhizaes, 5～45 parts of Radix Gentianae Macrophyllae and Fructus Chaenomeliss.
Further be 10～80 parts of 10～80 parts of Herba Pyrolaes, 5～45 parts of big gun first, 5～20 parts of south Acanthopanax gracilistylus, 10～80 parts of Ramulus Moris, 10～80 parts of Radix Salviae Miltiorrhizaes, 5～45 parts of Radix Gentianae Macrophyllae, 5～45 parts of Fructus Chaenomeliss, 8～50 parts of Radix Angelicae Sinensis, 5～45 parts of Rhizoma Corydalis, 1～10 part of Scorpio and Radix Astragali.
Further be that 20～40 parts of Herba Pyrolaes, 10～20 parts of big gun first, 8～15 parts of south Acanthopanax gracilistylus, 20～40 parts of Ramulus Moris, 20～40 parts of Radix Salviae Miltiorrhizaes, 10～20 parts of Radix Gentianae Macrophyllae, 10～20 parts of Fructus Chaenomeliss, 10～30 parts of Radix Angelicae Sinensis, 10～20 parts of Rhizoma Corydalis, 3～8 parts of Scorpio and 20～40 parts of Radix Astragali and pharmacy acceptable auxiliary are formed.
The best is 30 parts of 30 parts of Herba Pyrolaes, 15 parts of big gun first, 10 parts of south Acanthopanax gracilistylus, 30 parts of Ramulus Moris, 30 parts of Radix Salviae Miltiorrhizaes, 15 parts of Radix Gentianae Macrophyllae, 15 parts of Fructus Chaenomeliss, 20 parts of Radix Angelicae Sinensis, 15 parts of Rhizoma Corydalis, 5 parts of Scorpio and Radix Astragali.
Another object of the present invention provides a kind of method for preparing of Chinese medicine composition of the present invention, brings into play curative effect better for each raw material that makes this medicine, and the present composition can take following method for preparing to obtain.But these can not be used to limit the protection domain of the present composition.
Said Chinese medicine composition can be prepared from following method for preparing:
A, with Herba Pyrolae, south Acanthopanax gracilistylus and Ramulus Mori with alcohol extraction 1～3 time, each 0.5～3 hour, merge extractive liquid, reclaimed alcohol, it is subsequent use to be condensed into equivalent extract;
B, the big gun first is ground to form fine powder add mix homogeneously in the equivalent extract of steps A gained;
C, the adjuvant that the adding of B gained mixture is suited are prepared into corresponding pharmaceutical preparation.
Further, said Chinese medicine composition is prepared from following method for preparing:
A, with Herba Pyrolae, south Acanthopanax gracilistylus, Ramulus Mori, Radix Salviae Miltiorrhizae and Fructus Chaenomelis with alcohol extraction 1～3 time, each 0.5～3 hour, merge extractive liquid, reclaimed alcohol, it is subsequent use to be condensed into equivalent extract;
B, extract 1～3 time after gentiana macrophylla medicine soaked in containing cholamine, each 0.5～3 hour, merge extractive liquid, reclaimed alcohol, and it is subsequent use to be condensed into equivalent extract;
C, the big gun first is ground to form fine powder add mix homogeneously in the equivalent extract of steps A and B gained;
D, the adjuvant that the adding of C gained mixture is suited are prepared into corresponding pharmaceutical preparation.
Further, Chinese medicine composition according to the invention is prepared from following method for preparing:
A, with Herba Pyrolae, south Acanthopanax gracilistylus, Ramulus Mori, Radix Salviae Miltiorrhizae and Fructus Chaenomelis with alcohol extraction 1～3 time, each 0.5～3 hour, merge extractive liquid, reclaimed alcohol, it is subsequent use to be condensed into equivalent extract;
B, extract 1～3 time after gentiana macrophylla medicine soaked in containing cholamine, each 0.5～3 hour, merge extractive liquid, reclaimed alcohol, and it is subsequent use to be condensed into equivalent extract;
C, with Radix Angelicae Sinensis, Rhizoma Corydalis and Radix Astragali with water extraction 1～3 time, each 0.5～3 hour, filter, merge extractive liquid,, it is subsequent use to be condensed into equivalent extract;
D, Scorpio and big gun first are ground to form fine powder add mix homogeneously in the equivalent extract of steps A, B and C gained;
E, the adjuvant that the adding of D gained mixture is suited are prepared into corresponding pharmaceutical preparation.
The present composition can adopt the conventional method of Chinese medicine preparation to be prepared into any conventional formulation; The active component that is about to the medicine of the present invention of gained adds various conventional adjuvant required when preparing different dosage form; Like disintegrating agent, lubricant, binding agent etc.; Method of Chinese medicinal with routine is prepared into corresponding preparations, comprises any modern preparation that allows on the pharmaceuticss such as injection type, peroral dosage form, percutaneous dosing dosage form, mucosa absorption dosage form.
Chinese medicine composition of the present invention is that cataplasma is prepared from following method:
A, claim 30 parts of 30 parts of Herba Pyrolaes, 15 parts of big gun first, 10 parts of south Acanthopanax gracilistylus, 30 parts of Ramulus Moris, 30 parts of Radix Salviae Miltiorrhizaes, 15 parts of Radix Gentianae Macrophyllae, 15 parts of Fructus Chaenomeliss, 20 parts of Radix Angelicae Sinensis, 15 parts of Rhizoma Corydalis, 5 parts of Scorpio and Radix Astragali by weight;
B, with the Herba Pyrolae that takes by weighing, south Acanthopanax gracilistylus, Ramulus Mori, Radix Salviae Miltiorrhizae and Fructus Chaenomelis with 70% ethanol extraction 2 times, 0.5 hour for the first time, 2 hours for the second time, filter, merging filtrate reclaims alcohol, it is subsequent use to be condensed into equivalent extract;
C, extract three times after gentiana macrophylla medicine soaked in containing cholamine, each each 2 hours, filter, merging filtrate reclaims alcohol, and it is subsequent use to be condensed into equivalent extract;
D, with Radix Angelicae Sinensis, Rhizoma Corydalis and Radix Astragali with water extraction 2 times, each 1 hour, filter, merge extractive liquid,, it is subsequent use to be condensed into equivalent extract;
E, Scorpio and big gun first are ground to form fine powder add mix homogeneously in the equivalent extract of step B, C and D gained;
F, the adjuvant that the adding of E gained mixture is suited are prepared into cataplasma.
Chinese medicine composition of the present invention has wind-damp dispelling, qualcomm meridian, the effect of strong muscle of invigorating blood circulation, and clinical observation shows that Chinese medicine composition of the present invention can be widely used in diseases such as anti-dispelling the wind and dampness pathogens numbness disease.
The oral effective daily dose of the present invention is 3～250g raw medicinal herbs, divides and takes for 2～3 times.
The pharmacodynamic study of Test Example 1, Chinese medicine composition of the present invention
One, trial drug
The cataplasma of the embodiment of the invention 1,2 and 5 gained, every 6.5cm * 9cm; SHEXIANG ZHUANGGU GAO, by every 7cm * 10cm, every 100cm2 is no less than 1.6g.
Two, experimental animal
KM kind mice, body weight 26-30g, male; Provide by Hu'nan Inst. of Plarmaceutical Industry.
Three, antiinflammatory action
Influence to mice ear: mice, male, 50; Be divided into 5 groups at random; Give following medicine respectively: (1) matched group (excipient), (2) SHEXIANG ZHUANGGU GAO (291.2mg/kg), Chinese medicine composition 1 of the present invention (embodiment 1 sample), 2 (embodiment 2 samples) and 3 (embodiment 5 samples); Auricle QUMAO before the test, the place's administration of auris dextra QUMAO.Be administered once every day, continuous 7d, 1h after the last administration, every Mus auris dextra melted paraxylene 50 μ 1; Left side ear compares, and behind the 30min, the auris dextra exterior feature is administered once again; With sacrifice of animal, cut left and right sides ear behind the 2h, use straight through being the auricle same area punching of 7mm card punch along the left and right sides; The both sides auricle is weighed respectively, with two auricle weight differences as the swelling degree, between organizing with t check relatively.Result's (seeing table 1), Chinese medicine composition of the present invention all can obviously suppress the mice auricle swelling that xylene causes, has antiinflammatory action.
The influence of table 1 pair mice ear (n=10, X ± SD)
Compare * P＜0.05, * * P＜0.01 with matched group.
Four, analgesic activity
Mice, 50, ♀, ♂ half and half are divided into 5 groups at random; Give following medicine respectively: (1) matched group (excipient), (2) SHEXIANG ZHUANGGU GAO (291.2mg/kg), Chinese medicine composition 1 of the present invention (embodiment 1 sample), 2 (embodiment 2 samples) and 3 (embodiment 5 samples), the depilation of test preabdomen; About 2cm * the 2cm of area, for administration, be administered once every day; For three days on end, 1h after the last administration, every Mus lumbar injection 0.7% acetum 0.2ml/ are only; Observe the mouse writhing number of times (the abdominal part indent stretches hind leg, and buttocks is raised) in the mice 20 minutes.With t check carrying out group difference significance relatively, result's (seeing table 5) shows that (the 175mg crude drug/kg) the writhing response number of times of mice obviously reduces Chinese medicine composition of the present invention, has the analgesic effect.
Table 5 analgesic activity (writhing method) (n=10, X ± SD)
Compare * P＜0.05, * * P＜0.01 with matched group.
Result of the test shows: Chinese medicine composition of the present invention can reduce acetic acid induced mice writhing response number of times, has stronger analgesic activity.
In sum, Chinese medicine composition of the present invention has stronger antiinflammatory, analgesic activity.
The specific embodiment
Below come further to set forth present composition and preparation method thereof through embodiment.
Embodiment 1, cataplasma of the present invention
Take by weighing Herba Pyrolae 80g, big gun first 45g, south Acanthopanax gracilistylus 20g and Ramulus Mori 30g, with Herba Pyrolae, south Acanthopanax gracilistylus and Ramulus Mori with 75% ethanol extraction 3 times, each each 2 hours; Filter, merging filtrate reclaims ethanol; Concentrating under reduced pressure is dried to dry extract, adds the big gun first that has ground to form fine powder, mix homogeneously; Add an amount of cataplasma adjuvant again, be prepared into cataplasma 100 according to conventional method and paste.
Embodiment 2, cataplasma of the present invention
Take by weighing Herba Pyrolae 30g, big gun first 5g, south Acanthopanax gracilistylus 20g, Ramulus Mori 60g, Radix Salviae Miltiorrhizae 10g, Radix Gentianae Macrophyllae 45g and Fructus Chaenomelis 5g, above-mentioned big gun first is ground to form fine powder, Radix Gentianae Macrophyllae soaks in containing cholamine after 2 hours and extracted 3 hours, filters, and reclaims alcohol, filtrate for later use; Again with other medical materials with 70% ethanol extraction 2 times, 3 hours for the first time, 0.5 hour for the second time, filter, merging filtrate reclaims alcohol; Merge with Radix Gentianae Macrophyllae filtrating, concentrating under reduced pressure becomes dry extract again, adds big gun first powder, and mix homogeneously adds an amount of cataplasma adjuvant again, is prepared into cataplasma 100 according to conventional method and pastes.
Embodiment 3, tablet of the present invention
Take by weighing Herba Pyrolae 40g, big gun first 10g, south Acanthopanax gracilistylus 8g, Ramulus Mori 20g, Radix Salviae Miltiorrhizae 20g, Radix Gentianae Macrophyllae 10g part, Fructus Chaenomelis 20g, Radix Angelicae Sinensis 10g, Rhizoma Corydalis 20g, Scorpio 8g and Radix Astragali 20g; With Herba Pyrolae, south Acanthopanax gracilistylus, Ramulus Mori, Radix Salviae Miltiorrhizae and Fructus Chaenomelis with 65% ethanol extraction 2 times; Each 3 hours; Merge extractive liquid,, it is subsequent use to reclaim alcohol; Gentiana macrophylla medicine soaked in containing cholamine extract 3 times after 1 hour, each 0.5 hour, merge extractive liquid,, it is subsequent use to reclaim alcohol; Again with Radix Angelicae Sinensis, Rhizoma Corydalis and Radix Astragali with water extraction 3 hours, filter, above-mentioned each extracting solution is merged, be condensed into dry extract and add Scorpio and the big gun first that grinds to form fine powder, mix homogeneously, the additive of tablet that adding suits is prepared into 100 in tablet.
Embodiment 4, pellet capsule of the present invention
Take by weighing Herba Pyrolae 10g, big gun first 45g, south Acanthopanax gracilistylus 5g, Ramulus Mori 80g, Radix Salviae Miltiorrhizae 80g, Radix Gentianae Macrophyllae 20g, Fructus Chaenomelis 10g, Radix Angelicae Sinensis 30g, Rhizoma Corydalis 10g, Scorpio 3g and Radix Astragali 40g; With Herba Pyrolae, south Acanthopanax gracilistylus, Ramulus Mori, Radix Salviae Miltiorrhizae and Fructus Chaenomelis with 70% ethanol extraction 2 times; 0.5 hour for the first time, 2 hours for the second time, filter; Merging filtrate, it is subsequent use to reclaim alcohol; Gentiana macrophylla medicine soaked in containing cholamine extract 3 times after 1 hour, each each 2 hours, filter, merge extractive liquid,, it is subsequent use to reclaim alcohol; Again with Radix Angelicae Sinensis, Rhizoma Corydalis and Radix Astragali with water extraction 2 times, each 1 hour, filter; Above-mentioned each extracting solution is merged, be condensed into dry extract and add Scorpio and the big gun first that grinds to form fine powder, mix homogeneously; Add suitable an amount of pellet capsule adjuvant, be prepared into 100 of pellt capsules according to conventional method.
Embodiment 5, cataplasma of the present invention
Take by weighing Herba Pyrolae 30g, big gun first 15g, south Acanthopanax gracilistylus 10g, Ramulus Mori 30g, Radix Salviae Miltiorrhizae 10g, Radix Gentianae Macrophyllae 15g, Fructus Chaenomelis 15g, Radix Angelicae Sinensis 20g, Rhizoma Corydalis 15g, Scorpio 5g and Radix Astragali 10g; With Herba Pyrolae, south Acanthopanax gracilistylus, Ramulus Mori, Radix Salviae Miltiorrhizae and Fructus Chaenomelis with 70% ethanol extraction 2 times; 0.5 hour for the first time, 2 hours for the second time, filter; Merging filtrate, it is subsequent use to reclaim alcohol; Gentiana macrophylla medicine soaked in containing cholamine extract 3 times after 1 hour, each each 2 hours, filter, merge extractive liquid,, it is subsequent use to reclaim alcohol; Again with Radix Angelicae Sinensis, Rhizoma Corydalis and Radix Astragali with water extraction 2 times; Each 1 hour, filter, above-mentioned each extracting solution is merged; Be condensed into dry extract and add Scorpio and the big gun first mix homogeneously that grinds to form fine powder, add suitable cataplasma adjuvant and be prepared into cataplasma 100 subsides according to conventional method.
Embodiment 6, capsule of the present invention
Take by weighing Herba Pyrolae 60g, big gun first 45g, south Acanthopanax gracilistylus 15g, Ramulus Mori 40g, Radix Salviae Miltiorrhizae 30g, Radix Gentianae Macrophyllae 5g, Fructus Chaenomelis 45g, Radix Angelicae Sinensis 50g, Rhizoma Corydalis 5g, Scorpio 1g and Radix Astragali 80g; With Herba Pyrolae, south Acanthopanax gracilistylus, Ramulus Mori, Radix Salviae Miltiorrhizae and Fructus Chaenomelis with 90% ethanol extraction 2 hours; Filter, it is subsequent use to reclaim alcohol; Gentiana macrophylla medicine soaked in containing cholamine after 2 hours extracted 2 hours, filter, it is subsequent use to reclaim alcohol; Again with Radix Angelicae Sinensis, Rhizoma Corydalis and Radix Astragali with water extraction 2 hours, filter, above-mentioned each filtrating is merged, be condensed into equivalent extract and add Scorpio and the big gun first mix homogeneously that grinds to form fine powder, the adding an amount of capsule adjuvant that suits is prepared into 100 of capsules according to conventional method.
Embodiment 7, granule of the present invention
Take by weighing Herba Pyrolae 20g, big gun first 15g, south Acanthopanax gracilistylus 20g, Ramulus Mori 10g, Radix Salviae Miltiorrhizae 20g, Radix Gentianae Macrophyllae 15g, Fructus Chaenomelis 45g, Radix Angelicae Sinensis 8g, Rhizoma Corydalis 45g, Scorpio 10g and Radix Astragali 40g; With Herba Pyrolae, south Acanthopanax gracilistylus, Ramulus Mori, Radix Salviae Miltiorrhizae and Fructus Chaenomelis with 75% ethanol extraction 3 hours; Filter, it is subsequent use to reclaim alcohol; Gentiana macrophylla medicine soaked in containing cholamine after 3 hours extracted 1.5 hours, filter, it is subsequent use to reclaim alcohol; Again with Radix Angelicae Sinensis, Rhizoma Corydalis and Radix Astragali with water extraction 2 times, each 2 hours, filter; Above-mentioned each filtrating is merged; Be condensed into equivalent extract and add Scorpio and the big gun first mix homogeneously that grinds to form fine powder, add suitable an amount of granule adjuvant, be prepared into granule 100 bags according to conventional method.
Embodiment 8, plaster of the present invention
Take by weighing Herba Pyrolae 80g, big gun first 15g, south Acanthopanax gracilistylus 20g, Ramulus Mori 15g, Radix Salviae Miltiorrhizae 10g, Radix Gentianae Macrophyllae 25g and Fructus Chaenomelis 30g, Herba Pyrolae, south Acanthopanax gracilistylus, Ramulus Mori, Radix Salviae Miltiorrhizae and Fructus Chaenomelis with 75% ethanol extraction 3 hours, are filtered, it is subsequent use to reclaim alcohol; Gentiana macrophylla medicine soaked in containing cholamine after 3 hours extracted 1.5 hours, filter, it is subsequent use to reclaim alcohol; Above-mentioned each filtrating is merged, be condensed into equivalent extract and add Scorpio and the big gun first mix homogeneously that grinds to form fine powder, add suitable an amount of plaster adjuvant, be prepared into plaster 100 according to conventional method and paste.
Claims (12)
1. the Chinese medicine composition of an expelling wind and removing dampness is characterized in that each crude drug by following weight parts: 10～80 parts of Herba Pyrolaes, 5～45 parts of big gun first, 5～20 parts of south Acanthopanax gracilistylus and Ramulus Mori adopt the active component and the pharmacy acceptable auxiliary of the conventional method gained of Chinese medicine preparation to form for 10～80 parts.
2. Chinese medicine composition according to claim 1 is characterized in that said Chinese medicine composition is prepared from following method for preparing:
A, with Herba Pyrolae, south Acanthopanax gracilistylus and Ramulus Mori with alcohol extraction 1～3 time, each 0.5～3 hour, merge extractive liquid, reclaimed alcohol, it is subsequent use to be condensed into equivalent extract;
B, the big gun first is ground to form fine powder add mix homogeneously in the equivalent extract of steps A gained;
C, the adjuvant that the adding of B gained mixture is suited are prepared into corresponding pharmaceutical preparation.
3. the Chinese medicine composition of an expelling wind and removing dampness is characterized in that said Chinese medicine composition each crude drug by following weight portion: 10～80 parts of Herba Pyrolaes, 5～45 parts of big gun first, 5～20 parts of south Acanthopanax gracilistylus, 10～80 parts of Ramulus Moris, 10～80 parts of Radix Salviae Miltiorrhizaes, 5～45 parts of Radix Gentianae Macrophyllae and Fructus Chaenomelis adopt the active component and the pharmacy acceptable auxiliary of the conventional method gained of Chinese medicine preparation to form for 5～45 parts.
4. Chinese medicine composition according to claim 3 is characterized in that said Chinese medicine composition is prepared from following method for preparing:
A, with Herba Pyrolae, south Acanthopanax gracilistylus, Ramulus Mori, Radix Salviae Miltiorrhizae and Fructus Chaenomelis with alcohol extraction 1～3 time, each 0.5～3 hour, merge extractive liquid, reclaimed alcohol, it is subsequent use to be condensed into equivalent extract;
B, extract 1～3 time after gentiana macrophylla medicine soaked in containing cholamine, each 0.5～3 hour, merge extractive liquid, reclaimed alcohol, and it is subsequent use to be condensed into equivalent extract;
C, the big gun first is ground to form fine powder add mix homogeneously in the equivalent extract of steps A and B gained;
D, the adjuvant that the adding of C gained mixture is suited are prepared into corresponding pharmaceutical preparation.
5. the Chinese medicine composition of an expelling wind and removing dampness is characterized in that said Chinese medicine composition each raw material by following weight portion: 10～80 parts of Herba Pyrolaes, 5～45 parts of big gun first, 5～20 parts of south Acanthopanax gracilistylus, 10～80 parts of Ramulus Moris, 10～80 parts of Radix Salviae Miltiorrhizaes, 5～45 parts of Radix Gentianae Macrophyllae, 5～45 parts of Fructus Chaenomeliss, 8～50 parts of Radix Angelicae Sinensis, 5～45 parts of Rhizoma Corydalis, 1～10 part of Scorpio and Radix Astragali adopt the active component and the pharmacy acceptable auxiliary of the conventional method gained of Chinese medicine preparation to form for 10～80 parts.
6. Chinese medicine composition according to claim 5 is characterized in that said Chinese medicine composition is prepared from following method for preparing:
A, with Herba Pyrolae, south Acanthopanax gracilistylus, Ramulus Mori, Radix Salviae Miltiorrhizae and Fructus Chaenomelis with alcohol extraction 1～3 time, each 0.5～3 hour, merge extractive liquid, reclaimed alcohol, it is subsequent use to be condensed into equivalent extract;
B, extract 1～3 time after gentiana macrophylla medicine soaked in containing cholamine, each 0.5～3 hour, merge extractive liquid, reclaimed alcohol, and it is subsequent use to be condensed into equivalent extract;
C, with Radix Angelicae Sinensis, Rhizoma Corydalis and Radix Astragali with water extraction 1～3 time, each 0.5～3 hour, filter, merge extractive liquid,, it is subsequent use to be condensed into equivalent extract;
D, Scorpio and big gun first are ground to form fine powder add mix homogeneously in the equivalent extract of steps A, B and C gained;
E, the adjuvant that the adding of D gained mixture is suited are prepared into corresponding pharmaceutical preparation.
7. Chinese medicine composition according to claim 5 is characterized in that said Chinese medicine composition each crude drug by following weight parts: 20～40 parts of Herba Pyrolaes, 10～20 parts of big gun first, 8～15 parts of south Acanthopanax gracilistylus, 20～40 parts of Ramulus Moris, 20～40 parts of Radix Salviae Miltiorrhizaes, 10～20 parts of Radix Gentianae Macrophyllae, 10～20 parts of Fructus Chaenomeliss, 10～30 parts of Radix Angelicae Sinensis, 10～20 parts of Rhizoma Corydalis, 3～8 parts of Scorpio and Radix Astragali adopt the active component and the pharmacy acceptable auxiliary of the conventional method gained of Chinese medicine preparation to form for 20～40 parts.
8. Chinese medicine composition according to claim 7 is characterized in that said Chinese medicine composition is prepared from following method:
A, take by weighing 30 parts of 30 parts of Herba Pyrolaes, 15 parts of big gun first, 10 parts of south Acanthopanax gracilistylus, 30 parts of Ramulus Moris, 30 parts of Radix Salviae Miltiorrhizaes, 15 parts of Radix Gentianae Macrophyllae, 15 parts of Fructus Chaenomeliss, 20 parts of Radix Angelicae Sinensis, 15 parts of Rhizoma Corydalis, 5 parts of Scorpio and Radix Astragali by weight;
B, with the Herba Pyrolae that takes by weighing, south Acanthopanax gracilistylus, Ramulus Mori, Radix Salviae Miltiorrhizae and Fructus Chaenomelis with 70% ethanol extraction 2 times, 0.5 hour for the first time, 2 hours for the second time, filter, merging filtrate reclaims alcohol, it is subsequent use to be condensed into equivalent extract;
C, extract three times after gentiana macrophylla medicine soaked in containing cholamine, each each 2 hours, filter, merging filtrate reclaims alcohol, and it is subsequent use to be condensed into equivalent extract;
D, with Radix Angelicae Sinensis, Rhizoma Corydalis and Radix Astragali with water extraction 2 times, each 1 hour, filter, merge extractive liquid,, it is subsequent use to be condensed into equivalent extract;
E, Scorpio and big gun first are ground to form fine powder add mix homogeneously in the equivalent extract of step B, C and D gained;
F, the adjuvant that the adding of E gained mixture is suited are prepared into pharmaceutically corresponding preparations.
9. according to each described Chinese medicine composition of claim 1 to 8, it is characterized in that said Chinese medicine composition is any Chinese medicine preparation that allows on the pharmaceutics.
10. want 9 described Chinese medicine compositions according to right, it is characterized in that said preparation is peroral dosage form, injection type or transdermal dosage form.
11. Chinese medicine composition according to claim 10 is characterized in that said transdermal dosage form is a cataplasma.
12. the application of Chinese medicine composition according to claim 9 in the pain caused medicine of preparation treatment rheumatic arthralgia, scapulohumeral periarthritis.
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| CN102755487A (en) * | 2012-07-24 | 2012-10-31 | 孙淑银 | Traditional Chinese medicine powder for eliminating dampness and invigorating blood circulation |
| CN104126954A (en) * | 2014-08-04 | 2014-11-05 | 李玉成 | Health care kneepad and manufacturing method thereof |
| CN104958423A (en) * | 2015-07-09 | 2015-10-07 | 范道柱 | Traditional Chinese medicine preparation for treating tuberculous arthritis and preparation method |
| CN104940390A (en) * | 2015-07-09 | 2015-09-30 | 范道柱 | Traditional Chinese medicine preparation for treating knee arthroncus and preparation method thereof |
| CN104940424A (en) * | 2015-07-09 | 2015-09-30 | 范道柱 | Traditional Chinese medicine preparation for treating knee arthroncus and preparation method thereof |
| CN104958422A (en) * | 2015-07-09 | 2015-10-07 | 范道柱 | Traditional Chinese medicine combination for treating crane-knee arthritis and preparation method |
| CN107441273A (en) * | 2017-10-11 | 2017-12-08 | 南京正宽医药科技有限公司 | A kind of medicinal liquor for rheumatism and preparation method thereof |
| CN107669798A (en) * | 2017-10-29 | 2018-02-09 | 陈德进 | A kind of composition for treating cold rheumatoid joint pain |
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| CN101317996A (en) * | 2007-01-20 | 2008-12-10 | 徐长山 | Traditional Chinese medicine emplastrum for rheumatism of muscles and bones |
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| 吴名波等.中成药治疗类风湿性关节炎临床研究进展.《中华中医药学刊》.2008,第26卷(第09期),1974-1976. * |
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