CN103893727A - Pain-relieving, blood-invigorating and tendon-relaxing plaster and preparation method thereof - Google Patents

Pain-relieving, blood-invigorating and tendon-relaxing plaster and preparation method thereof Download PDF

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CN103893727A
CN103893727A CN201410123893.9A CN201410123893A CN103893727A CN 103893727 A CN103893727 A CN 103893727A CN 201410123893 A CN201410123893 A CN 201410123893A CN 103893727 A CN103893727 A CN 103893727A
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rhizoma
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radix angelicae
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CN103893727B (en
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禹骏
史铭均
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Abstract

The invention discloses a pain-relieving, blood-invigorating and tendon-relaxing plaster and a preparation method thereof. The pain-relieving, blood-invigorating and tendon-relaxing plaster comprises the following components in percentage by weight: 0.1-30% of rhizoma zingiberis, 0.1-20% of rhizoma kaempferiae, 0.1-20% of radix angelicae, 0.1-15% of rhizoma nardostachyos, 0.1-15% of rheum officinale, 0.1-10% of divaricate saposhnikovia roots, 0.1-10% of radix clematidis, 0.1-10% of lumbricus, 0.1-10% of resina draconis, 0.1-10% of coptis chinensis, 0.1-10% of garden balsam stems, 0.1-10% of lycopodium clavatum, 0.1-10% of caulis Spatholobi, 0.1-10% of myrrh, 0.1-10% of frankincense, 0.1-10% of borneol, 0.1-10% of peach kernels, 0.1-10% of angelica sinensis, 0.1-10% of syzygium aromaticum, 0.1-10% of pepper, 0.1-10% of cortex periplocae, 0.1-10% of Schizonepeta, 0.1-10% of cassia twig, 0.1-10% of magnolia flowers, 0.1-10% of notopterygium roots, 0.1-10% of ligusticum wallichii, 0.1-10% of radix angelicae pubescentis, 0.1-10% of moutan barks, 0.1-10% of pepper, 0.1-10% of rhizoma Atractylodis, 0.1-10% of menthol, 0.1-15% of methyl salicylate, 0.1-10% of ground beeltles, 0.1-15% of raw pinellia ternate, 0.1-10% of safflower carthamus and 0.1-10% of camphor. The pain-relieving, blood-invigorating and tendon-relaxing plaster disclosed by the invention has good anti-inflammatory and analgesic effects and an effect of promoting blood circulation to remove blood stasis, and not only can thoroughly relieve osteoproliferation, arthralgia and myalgia and arthralgia, but also has good curative effect on tuberculosis of spermary and epididymis, particularly on muscular paralysis.

Description

A kind of relieving pain and activating blood circulation relaxing muscles and tendons plaster and preparation method thereof
Technical field
The present invention relates to treat the medicine of bone matrix hyperplasia, bones and muscles pain, muscular paralysis and arthralgia, is the Exterior-applied Chinese patent medicine of preparing take Chinese herbal medicine as raw material, relates in particular to a kind of relieving pain and activating blood circulation relaxing muscles and tendons plaster and preparation method thereof.
Background technology
Bone matrix hyperplasia is called again hyperplastic osteoarthritis, osteoarthritis, degenerated arthrosis, senile arthritis, hypertrophiarthritis, due to the cartilage, the intervertebral disc that form joint, soft tissue degeneration, the degenerations such as ligament, edge, joint forms bony spur, and synovial membrane plumpness waits variation, and there is osteoclasia, cause insecondary hyperosteogeny, cause joint deformity, in the time being subject to abnormal load, cause arthralgia, a kind of disease of the symptoms such as limitation of activity.Divide two kinds of constitutional and Secondary cases.
Hyperosteogeny of cervical vertebra: clinical manifestation has: there is strong sensation in neck portion, limitation of activity, cervical region activity has snap sound, pain is often to shoulder and upper limb radiation, and hands and finger have numbness, electric shock sample sensation, can increase the weight of because cervical region is movable, different pathological changes are involved different parts, just occur different symptoms, can cause paralysis late period.Hyperosteogeny of cervical vertebra severe patient also can cause cervical vertebra characteristic of disease hypertension, cardiovascular and cerebrovascular disease, gastritis, angina pectoris, dysphagia etc.
Distending pain, often appears that lumbar vertebra and lumbar soft tissue ache, in lumbar vertebra hyperosteogeny: site of pathological change is the most common with waist three, waist four clinically, stiff and tired sense, even bends over limited, as contiguous root compression, can cause corresponding symptom, occur local pain, send out stiff, rear neuralgia, numb etc., as compressing sciatic nerve can cause sciatic neuritis, occur the violent fiber crops pain of suffering limb, causalgia, takes out pain, string pain, to whole lower limb radiation.
Knee joint hyperosteogeny: the slow person's gonalgia of initial stage onset is not serious, there is sustainability dull pain, when temperature reduces, pain increases the weight of, relevant with climate change, come into play after rising morning, long-time walking, strenuous exercise or the sitting gonalgia that stands up while starting to walk is stiff, after slightly movable, take a turn for the better, upper difficulty downstairs, downstairs time, knee joint is felt like jelly, easily fall down, pain while crouching, stiff, joint aches distending pain when serious, limping is walked, merge rheumatism patient redness and swelling of joints, deformity, function limitation, stretch the activity of bending and have snap sound, the visible hydrarthrosis of some patients were, there is obvious tumefaction part, compression phenomena.
Arthralgic patient belongs to damage and the catabiosis naturally of articular cartilage.Cartilage is the material along joint arrangement, and it can prevent that bone end from rubbing together mutually, and allows joint move freely under the state that is full of joint fluid.Gradually old when people's age, the cartilage of human body is worn, and bone has just exposed, the joint that finger, knee, neck etc. are located and joint be close together activity when friction with regard to pain, swelling, stiff, had sound.In addition, aging gradually along with health, the ability that health self produces II type bone gelatin and Glucoamino polysaccharide also constantly declines, only have and directly supplement II type bone gelatin and calcium, constantly recovery, reconstruction, Articular Cartilage tissue and sheath, prevent its degeneration, keep its integrity, rebuild bone elite and make joint no longer because of activity friction pain.
Bones and muscles pain is the defect of old people Chang You, but as infectious disease, in Chinese middle-aged adults, spreads.Before computer, sit a whole day neck pain; In air-conditioned room, treat for a long time lumbago; Mouse has used wrist pain many.Swim and pain in my shoulder once in a while, the knee pain of coming back of climbing the mountain ... people is not old, and why " muscles and bones " expert that first declines points out, athletic injury is the main cause that causes many youngster whole bodies " bones and muscles pain ".And whole-body muscle joint also wind-engaging, cold, summer-heat, wet, dry, fiery " six climate exopathogens " attack or wound, chronic strain, transdermal is pathogenic and form " six poison " to the marrow, be exactly we usually said " bone poison "." bone poison " long-term existence forms " place poison " on bone and periosteum.Place poison makes bone and soft hyperemia, edema, adhesion, the contracture repeatedly of knitting of periarticular, thereby cause local blood circulation obstacle, produce a large amount of acidic materials and stimulate blood vessel, infringement muscular tissue, shows as muscle muscles and bones joint aches, numb, swelling, even red and swollen distortion, severe one can cause the destruction of joint sclerotin, and joint deformity be can't take care of oneself.Bones and muscles pain is the clinically important form of expression of rheumatic osteopathia, process emphatically.
Neck, shoulder, waist, skelalgia and osteoarthrosis pain are the very common pain syndromes of the mankind.Patient accounts for adult's 23%, and only China patient just reaches 300,000,000 crowd.Such syndrome is except spraining the unexpected factors such as traumatic injury, its reflection on pathology many degenerative change, hyperosteogeny, vertebral pulp degeneration, fibrous ring calcifications with spinal column, breaks, annuler bulge, gives prominence to and be associated.Show as clinically headache, dizziness, visual deterioration, extremity activity and be obstructed, and accompany radiated pain and numb, feel cold, swelling, even amyotrophy and disabling.Tcm clinical practice research thinks, this is invasion and attack and the chronic strain that is subject to for a long time wind, cold, wet, or bad work habit, living habit, bring out body tissue degenerative change, the acidic materials alluvial of microcirculation metabolism, forces meridians impaired, QI and blood being obstructed, due to poor blood circulation.Traditional Chinese Medicine is referred to as " arthromyodynia ".The treatment of above-mentioned disease is mainly with traction, operation, physical therapy, partial closure, acupuncture etc.But all only play the effect of alleviation, temporary transient pain relieving, long-term effect is poor.And treatment time, long cost was many, caused very large financial burden to patient.
Summary of the invention
In view of this, the object of the invention is to overcome problems of the prior art, a kind of relieving pain and activating blood circulation relaxing muscles and tendons plaster and preparation method thereof is provided.
The pharmacology of each crude drug and drug effect in the present invention:
1. Rhizoma Zingiberis
Chinese medicine voluminous dictionary is recorded, and Rhizoma Zingiberis has analgesic activity.
[pharmacology] analgesic activity
Rhizoma Zingiberis methanolic extract 10g(crude drug)/kg subcutaneous injection, can obviously suppress the reaction of mice acetic acid twisting, but hot plate method is without analgesic activity.Rhizoma Zingiberis ether extract (oily liquids) 1.5mg/kg or 3.0ml/kg, residue water extract 20g/kg gavage after ether extracts, all can suppress the reaction of mice acetic acid twisting, and the former effect is stronger, and can obviously extend the incubation period of Spurs Severe Pain reaction.
[function] warming spleen and stomach for dispelling cold, recuperating depleted YANG is promoted blood circulation.
[curing mainly] arthralgia due to cold-dampnes.
2. Rhizoma Kaempferiae
Chinese medicine voluminous dictionary is recorded, and Rhizoma Kaempferiae has:
[function] warming middle-JIAO, pain relieving.
[curing mainly] toothache, treating swelling and pain by traumatic injury.
3. the Radix Angelicae Dahuricae
Chinese medicine voluminous dictionary is recorded, and the Radix Angelicae Dahuricae has analgesia, sedation.
[pharmacology] analgesia, sedation
Essential Oil of Radix Angelicae Dahuricae, in mouse writhing method, hot plate method, radiant heat stimulus method and the experiment of Rat Tall Flick method, shows analgesic activity, and suppresses mice autonomic activities.Volatile oil does not show physical dependence in mouse jump reaction experiment, the experiment of mice straub tail reaction.Phellopterin is the partial agonist of maincenter benzodiazepine receptors, the external inhibition [ 3h] diazepam etc. is attached to the Benzodiazepine site of rat brain gamma-aminobutyric acid receptor.
[function] expelling wind and removing dampness, understand things pain-stopping, detumescence and apocenosis.
[curing mainly] supraorbital bone pain, toothache.
4. Radix Et Rhizoma Nardostachyos
Chinese medicine voluminous dictionary is recorded, and Radix Et Rhizoma Nardostachyos has anti-microbial effect.
[pharmacology] anti-microbial effect
Radix Et Rhizoma Nardostachyos has inhibitory action to tubercule bacillus in vitro.Quintessence oil in jatamansi suppresses Salmonella typhi, xanthomonas campestris, Bacillus anthracis and Colletotrichum bacterium etc.The quintessence oil of jatamansi is to flavacin, the also selective inhibitory or killing effect such as hair aspergillus.Radix Et Rhizoma Nardostachyos peroxide in Radix Et Rhizoma Nardostachyos and different Radix Et Rhizoma Nardostachyos peroxide have antimalarial active to Plasmodium falciparum.
[function] regulating QI to relieve pain.
[curing mainly] toothache.
5. Radix Et Rhizoma Rhei
Chinese medicine voluminous dictionary is recorded, and Radix Et Rhizoma Rhei has antiinflammatory action,
[pharmacology] antiinflammatory action
(1) suppress zoopery inflammation: Radix Et Rhizoma Rhei decoct can significantly suppress Oleum Tiglii and cause mice auricular concha dosage form exudative inflammation.Emodin can significantly suppress the rat dosage form pleuritis that carrageenin causes, the rich and powerful capillary permeability that inhibition toes swelling and acetic acid cause increases.To early stage the oozing out of inflammation, the saturating property of blood capillary increases, and leukoplania etc. have good antagonism, and acute inflammation is had to obvious antagonism.
(2) the impact on pro-inflammatory cytokine: emodin can suppress leukotriene B 4(LTB 4) biosynthesis, energy activated mononuclear emiocytosis tumor necrosis factor-alpha (TNF-α) and interleukin-11,6,8(IL-1, IL-6, IL-8), the secretion of the above-mentioned factor that can also suppress to be induced by endogenous toxin, also can coordinate phytohaemagglutinin (PHA) activated mononuclear emiocytosis IL-2 and interferon-γ (INF-γ) simultaneously
The removing toxic substances of [function] blood stasis dispelling.
[curing mainly] traumatic injury.
6. Radix Saposhnikoviae
Chinese medicine voluminous dictionary is recorded, and Radix Saposhnikoviae has analgesia, calmness and anticonvulsant action.
[pharmacology] analgesia, calmness and anticonvulsant action:
(1) analgesic activity: subcutaneous injection alcohol preserved material 20g(crude drug)/kg or water decoction 40g(crude drug)/kg gavage, all can obviously suppress acetic acid induced mice writhing response.Observe with hot plate method, Radix Saposhnikoviae water decoction 15g/kg lumbar injection or water decoction 40g/kg gavage, all can obviously improve mice pain threshold.Electricity irritation Mus tail method shows, Radix Saposhnikoviae ethanol preserved material, to mouse gavaging 21.18g/kg and subcutaneous injection 42.36g/kg, all has certain analgesic activity, enough analgesia rates of administration be respectively 46.4% and 56.7%, 60min after analgesia rate be respectively 39.0% and 53.3%.
(2) sedation: Radix Saposhnikoviae decocting liquid 40g(crude drug)/kg gavage, be that spontaneous activity in mice obviously reduces, and can obviously improve mice in the 1min of the dosage of sleeping under the pentobarbital sodium threshold number of falling asleep.
(3) anticonvulsant action: the each 0.5ml of 50% Radix Saposhnikoviae liquid mouse stomach, every day 2 times, 6d continuously, the vigilance that electricity irritation is caused has certain antagonism.Radix Saposhnikoviae water extract 4g/kg lumbar injection is fainted from fear due to subcutaneous injection pentetrazole and strychnine nitrate, and generation prolongation of latency can make to faint from fear.
[function] expelling pathogenic wind from the body surface, removing dampness to relieve pain, relieving convulsion.
[curing mainly] rheumatic arthralgia.
7. Radix Clematidis
Chinese medicine voluminous dictionary is recorded, and Radix Clematidis has analgesic activity and antiinflammation.
[pharmacology] 1. analgesic activity: hot plate method experiment shows, lumbar injection Radix Clematidis decoct 2.5g/kg,, can improve the mice threshold of pain, and wine to process the analgesic activity of product strong and lasting.
2. antiinflammation: Radix Clematidis injection can significantly suppress the mice auricle swelling that dimethylbenzene causes, can significantly suppress the rat granulation tissue growth that the scraps of paper cause.
[function] expelling wind and removing dampness, removing obstruction in the collateral to relieve pain.
[curing mainly] rheumatic arthralgia, numb limbs and tense tendons, passages through which vital energy circulates contracture, joint stuffiness.
8 Pheretimas
Chinese medicine voluminous dictionary is recorded, and Pheretima has antiinflammatory, analgesia and promotes wound healing effect.
[pharmacology] antiinflammatory, analgesia and the effect of promotion wound healing.
Lumbricus ethanol extract gavage and outer painting can obviously suppress the swelling of mice caused by dimethylbenzene xylene auricle, and carrageenin causes mice, rat paw edema, and acetic acid causes mouse peritoneal capillary permeability and increases, and Ovum Gallus domesticus album causes rat paw edema, extend hot plate method pain reaction incubation period.Pheretima can promote wound healing significantly, external application Pheretima extracting solution is in new zealand white rabbit back wound, can improve the healing rate of epidermis, muscle, promote the growth of fibroblast, blood capillary, collagen fiber and DNA in granulation tissue, increase the quantity of actin in head tissue, be conducive to wound contraction,
[function] relieving convulsion, relieve dizziness, high fever, infantile convulsions, epilepsy, etc., dredging collateral, relieving asthma.
[curing mainly] apoplectic hemiplegia, rheumatic arthralgia.
9 Sanguis Draxonis
Chinese medicine voluminous dictionary is recorded, and Sanguis Draxonis has antiinflammatory action.
[pharmacology] antiinflammatory action
Guangxi Sanguis Draxonis 2g/kg dosage is to mouse stomach, the mice otitis that obviously antagonism dimethylbenzene causes.20% Guangxi Sanguis Draxonis suspension coat rabbit scald position, to scald due to inflammation accelerate incrustation, promote wound healing.
The analgesic therapy of [function] dissipating blood stasis, hemostasis, promoting tissue regeneration and ulcer healing.
[curing mainly] traumatic injury, ecchymoma due to internal injury.
10. Rhizoma Coptidis
Chinese medicine voluminous dictionary is recorded, and Rhizoma Coptidis has antiinflammatory action.
[pharmacology] antiinflammatory action
Rhizoma Coptidis methanolic extract has antiinflammatory action to the toes swelling of rat kinds of experiments and granuloma, and local application also can alleviate granuloma development, and curative effect is similar with Phenylbutazone.And can suppress the mice auricular concha swelling that capillary permeability increases and dimethylbenzene causes that acetic acid or histamine cause.The release of berberine energy stimulation in rats ACTH, its antiinflammatory action may be relevant therewith.
[function] clearing away heat-fire, dampness, removing toxic substances.
[curing mainly] eczema.
11. Herba speranskiae tuberculataes
Chinese medicine voluminous dictionary is recorded, and Herba speranskiae tuberculatae has:
[function ]expelling wind and removing dampness, relaxing muscles and tendons to promote blood circulation, dissipating blood stasis for subsidence of swelling, removing toxic substances pain relieving.
[curing mainly] rheumatic arthralgia, muscles and bones contracture, lumbar strain, eczema.
12. Herba Lycopodiis
Chinese medicine voluminous dictionary is recorded, and Herba Lycopodii has anti-inflammatory analgesic action.
[pharmacology] anti-inflammatory analgesic action
There is good analgesic activity at Herba Lycopodii chloroform extraction position, n-butanol extraction position and water extraction position to heat to pain, wherein the strongest with the effect of chloroform extraction position, but 3 extract part Dichlorodiphenyl Acetates cause that writhing response is without impact.3 equal xylol of extract part cause mice otitis, acetic acid causes peritonitis and has remarkable inhibitory action, wherein all causing ankle swelling in rat with effect the strongest chloroform extraction position, chloroform extraction position PARA FORMALDEHYDE PRILLS(91,95) has significant antiinflammation, and other two positions act on without this.
[function] expelling wind and removing dampness, relaxing muscles and tendons to promote blood circulation.
[curing mainly] rheumatic arthralgia, joint are ached, skin numbness, traumatic injury.
13. Caulis Spatholobis
Chinese medicine voluminous dictionary is recorded, and Caulis Spatholobi has expansion blood vessel function.
[pharmacology] expands blood vessel function: electromagnetic flowmeter records dog femoral artery blood flow and vascular resistance, and Caulis Spatholobi water extract-alcohol precipitation preparation 20mg/kg directly injects femoral artery, and after injection, in 10min, femoral artery blood flow value added reaches 133%; Vascular resistance reduces 45.3%; The amount-effect curve that Caulis Spatholobi ethanol extraction makes phyenlephrinium (Phe), potassium chloride and calcium chloride shrink rat serum pipe ring all moves to right, and suppress ceiling effect, obviously weaken the interior stream of Ca dependency part in Phe contractile response, but caused according to interior Ca to Phe 2+discharging constriction does not have obvious relexation, prompting Caulis Spatholobi ethanol extraction expand blood vessel mechanism of action may with cell membrane on voltage-dependent Ca 2+passage or receptor-operated Ca 2+the inhibition of passage is relevant.
[function] relaxing muscles and tendons to promote blood circulation.
[curing mainly] numb hand and foot, quadriplegia, rheumatic arthralgia.
14. Myrrhas
Chinese medicine voluminous dictionary is recorded, and Myrrha has antiinflammatory, analgesic activity.
[pharmacology] antiinflammatory, analgesic activity: the multiple congener of Myrrha is all found to have the effects such as antiinflammatory.If the oleoresin ligroin extraction 500mg/kg of Myrrha is to rat oral gavage, can obviously suppress inflammation due to carrageenin and granuloma induced by implantation of cotton pellets, this extract also has obvious antipyretic effect mice.The raw product of Myrrha, fry product with vinegar goods are made decoct, powder and suspensoid, take the wound swelling of the sufficient sole of the foot of mice as index, the blood stasis swelling that wound is caused all has detumescence effect significantly, and the drug effect of each dosage form is close, drug effect there was no significant difference between each dosage group.
[function] blood stasis dispelling, detumescence, analgesic therapy.
[curing mainly] treating swelling and pain by traumatic injury, too fat to move skin infection.
15. Olibanums
Chinese medicine voluminous dictionary is recorded, and Olibanum has analgesic activity.
[pharmacology] analgesic activity: experiment showed, that by acetic acid twisting method mouse gavaging Olibanum has obvious analgesic activity.
[function] invigorates blood circulation, circulation of qi promoting, pain relieving.
[curing mainly] traumatic injury stasis of blood pain.
16. Borneolum Syntheticums
Chinese medicine voluminous dictionary is recorded, and Borneolum Syntheticum has:
[function ]logical all keys, loose stagnated fire, removing nebula improving eyesight, reducing swelling and alleviating pain.
[curing mainly] arthrodynia of extremities, rheumatism is gathered, and controls osteodynia.
17. Semen Persicaes
Chinese medicine voluminous dictionary is recorded, and Semen Persicae has antiinflammatory action.
[pharmacology] antiinflammatory action: the water extract of Semen Persicae has stronger Chinese People's Anti-Japanese Military and Political College's Mus carrageenin pedal swelling effect, therefrom separates to such an extent that 2 protein component PR-A and the quiet note of PR-B have the antiinflammatory action of dose dependent.Semen Persicae decoct is oral, and rat Granuloma formation is had to remarkable inhibitory action.Rat carrageenin forms granuloma, and prostaglandin E in the amount of transudate in granuloma and transudate is measured in Semen Persicae extract administration after 4d 2(PGE 2) content, its suppression ratio is 35%.Semen Persicae extracting solution is inhibited to the fibroblast growth in cell in vitro is cultivated, and uses it on family's model of rabbit of experimental below scleral valve trabeculectomy, finds that it has the effect of inflammation-inhibiting cell and proliferation of fibroblast.
[function] blood circulation promoting and blood stasis dispelling.
[curing mainly] traumatic injury, swelling and pain due to blood stasis.
18. Radix Angelicae Sinensis
Chinese medicine voluminous dictionary is recorded, and Radix Angelicae Sinensis has anti-inflammatory and antalgic, injury-resistance.
[pharmacology] anti-inflammatory and antalgic, injury-resistance: the Acute and chronic inflammation that water decoction of Angelica sinensis causes multiple proinflammatory agent all has inhibitory action significantly, extracts its antiinflammatory action after bilateral adrenal glands and still exists, and can lower rat inflammation and organize PGE 2burst size, reduce GPC bypass hemolytic activity, but can not antfhistamine proinflammatory effect short of money.AP can obviously reduce diethylstilbestrol and oxytocin and cause the writhing response number of times of dysmenorrhea model small mouse, extend the Ungula Bovis seu Bubali response latency, also can significantly suppress acetic acid induced mice writhing response, improve the threshold of pain of hot plate method induced mice pain sensation reaction, action intensity is relevant with metering.
[function] enriched blood and invigorated blood circulation.
[curing mainly] numbness of the skin, traumatic injury.
19. Flos Caryophyllis
Chinese medicine voluminous dictionary is recorded, and Flos Caryophylli has inhibition microbial action.
[pharmacology] suppresses microbial action
Ethanol extraction is effective to penicillin resistance staphylococcus aureus.Flos Caryophylli extract suppresses growth of H. pylori.Methanol crude extract selectivity suppresses oral cavity anaerobic bacteria, and effective ingredient is kaempferol etc.Flos Caryophylli extract antibacterial mechanisms may be synthetic with aminoacid glucosides class competitive inhibition protein.Eugenol is external has inhibitory or killing effect to many kinds of skin Xian bacterium.
[function] warming middle-JIAO, sending down the abnormal ascending QI, warming the kidney.
[curing mainly] ringworm, toothache, headache.
20. Fructus Piperiss
Chinese medicine voluminous dictionary is recorded, and Fructus Piperis has:
[function] warming spleen and stomach for dispelling cold, the therapeutic method to keep the adverse QI flowing downwards.
[curing mainly] cold expelling.
21. Cortex Periplocaes
Chinese medicine voluminous dictionary is recorded, and Cortex Periplocae has:
[function] wind-damp dispelling.
[curing mainly] rheumatic arthralgia.
22. Herba Schizonepetae
Chinese medicine voluminous dictionary is recorded, and Herba Schizonepetae has antiinflammatory action, analgesic activity.
[pharmacology] be analgesic activity Herba Schizonepetae water decoction 15g/kg gavage 1., 1h after administration, and the test of female mice hot plate method, makes to improve 300% after threshold of pain raising 200%, 4 ~ 5h.Main constituent d-menthone 100mg/kg gavage in Herba Schizonepetae oil, is 41.3% to the suppression ratio of mice acetic acid twisting reaction, and its intensity and aminophenazone are suitable.
2. antiinflammatory action: Herba Schizonepetae volatile oil main component pulegone 100mg/kg gavage is 39.8% to the suppression ratio of Abdominal effusion, and its antiinflammatory action intensity and aminophenazone are roughly equal.3-capryl alcohol and-pinene also has certain antiinflammatory action.In Herba Schizonepetae alabastrum, contained benzofuranyl acrylic acid derivative also has obvious antiinflammatory action, in vitro the IC to 3alpha-Hydroxysteroid dehydrogenase 50for 2.4ug/ml.
[function] blood stasis dispelling, induce sweat, rash, hemostasis.
[curing mainly] too fat to move pain relieving.
23. Ramulus Cinnamomi
Chinese medicine voluminous dictionary is recorded, Ramulus Cinnamomi has antipyretic, analgesic activity.
[pharmacology] is antipyretic, analgesic activity: Ramulus Cinnamomi water decoction and cinnamic aldehyde can make typhoid fever.Fever in rabbit temperature decline due to paratyphoid vaccine, and can make the body temperature of normal mouse reduce, its antipyretic and cooling effect may with its peripheral blood vessel, promote diaphoresis, dispel the heat relevant.
[function] expelling cold and relieving exterior syndrome, warming the meridian, activates yang.
[curing mainly] exterior syndrome due to wind-cold, arthralgia due to cold-dampnes, extreme cold of the limbs.
24. Flos Magnoliaes
Chinese medicine voluminous dictionary is recorded, and Flos Magnoliae has antiallergic and antiinflammatory action.
[pharmacology] antiallergic and antiinflammatory action: rat peritoneal mast cells histamine release inhibition test and passive skin allergic reaction (PCA) test show, Flos Magnoliae water extract has the effect of the histamine release of inhibition, water and methanolic extract have inhibitory action to PCA, and its effective ingredient is adenosine compounds.Flos Magnoliae volatile oil also has obvious anti-allergic effects, its ID to the three-dimensional ileum contraction of Cavia porcellus due to chronic reacting substance (SRS-A), histamine and acetylcholine (Ach) 50be respectively 30ug/ml, 18ug/ml, Guinea pig lung bar due to SRS-A is shunk, the anaphylaxis of egg protein sensitized guinea pig ileum is shunk and allergic asthma also has obvious antagonism.Find that with sensitized guinea pig ileum method and mouse skin capillary permeability experimental observation Flos Magnoliae has obvious anti-allergic effects, the effect that the capillary permeability that has obvious inhibition histamine to cause increases.Flos Magnoliae volatile oil can significantly suppress histamine phosphate, and the isolated ileum segments in guinea pigs that acecoline causes is shunk, and the anaphylaxis of the isolated ileum segments in guinea pigs of colonizing is shunk and is had stronger inhibitory action, and can obviously stop rat hypertrophy cell to take off granule.Flos Magnoliae volatile oil can reduce inflammation organizes the permeability of blood capillary, inflammation-inhibiting swelling, and the generation of inflammation-inhibiting medium, but do not affect the synthetic and secretion of adrenocortical hormone, its anti-inflammatory swelling effect does not rely on adrenal existence yet.
[function] dispersing wind and cold.
[curing mainly] ailment said due to cold or exposure, wind and cold.
25. Rhizoma Et Radix Notopterygiis
Chinese medicine voluminous dictionary is recorded, and Rhizoma Et Radix Notopterygii has analgesic activity.
[pharmacology] analgesic activity: 2% Rhizoma Et Radix Notopterygii volatile oil 10ml/kg lumbar injection, hot plate method in mice test can obviously improve the threshold of pain.Rhizoma Et Radix Notopterygii volatile oil 1.328ml/kg gavage or 0.133ml/kg lumbar injection, all can improve the thermostimulation threshold of pain, as successive administration 3d, can significantly reduce mice acetic acid twisting reaction times.Rhizoma Et Radix Notopterygii water extract is stronger than alcohol extract to the inhibitory action of mouse writhing reaction, but mice folder tail method or the experiment of boiling hot tail method show without analgesic activity.The experiment of mice acetic acid twisting method shows that the effective ingredient of Rhizoma Et Radix Notopterygii analgesic activity is 5 '-hydroxyl bergmot element.
[function] exterior cold of faling apart, wind-damp dispelling, sharp joint, pain relieving.
[curing mainly] rheumatic arthralgia, edema due to wind pathogen edema, sore swollen toxin.
26. Rhizoma Chuanxiongs
Chinese medicine voluminous dictionary is recorded, and Rhizoma Chuanxiong has:
[function ]blood circulation promoting and blood stasis dispelling, activating QI to alleviate the depression, wind-expelling pain-stopping.
[curing mainly] anemofrigid-damp arthralgia, traumatic injury, ulcer sores.
27. Radix Angelicae Pubescentiss
Chinese medicine voluminous dictionary is recorded, and Radix Angelicae Pubescentis has analgesia, calmness and antiinflammatory action.
[pharmacology] analgesia, calmness and antiinflammatory action: Radix Angelicae Pubescentis decoct or fluid extract, give rat or mice is oral or lumbar injection, all can produce calmness and syngignoscism, even can prevent the convulsion effect of strychnine to the frog, but can not make it avoid death.Hot plate method in mice proves, Radix Angelicae Pubescentis has analgesic activity.Lumbar injection osthenol formaldehyde can significantly suppress the rat hind paw edema of carrageenin induction and the mouse writhing reaction that acetic acid causes.
[function] expelling wind and dampness, dispersing cold for relieving pain.
[curing mainly] anemofrigid-damp arthralgia, lumbocrural pain.
28. Cortex Moutans
Chinese medicine voluminous dictionary is recorded, and Cortex Moutan has antiinflammatory action.
[pharmacology] antiinflammatory action: Cortex Moutan total glycosides 25,50,100mg/kg administration can obviously suppress in the rat dosage form foot pawl swelling of carrageenin induction and the mice auricle water of dimethylbenzene induction, and be obvious dose dependent relation, cause scorching before 1h give Cortex Moutan total glycosides (20 ~ 100mg/kg) adjuvant arthritis rats constitutional inflammation had to obvious inhibitory action, start gavage Cortex Moutan total glycosides (25 ~ 100mg/kg) and cause scorching rear 12d, 11d continuously, can significantly suppress the secondary inflammation reaction of adjuvant arthritis rats.Paeonol 0.5 ~ 1g/kg gavage or 50 ~ 200mg/kg lumbar injection are swollen to carrageenin, Ovum Gallus domesticus album, formaldehyde, histamine, 5-hydroxy tryptamine and Kallidin I rat foot, due to the auricle swelling of dimethylbenzene mice and acetic acid and endotoxin, abdominal cavity capillary permeability raises, and all has remarkable inhibitory action.The antiinflammatory action of Cortex Moutan and paeonol does not rely on Pituitary Adrenal system, and its mechanism may be many-sided, facedown inflammatory mediator, suppress leukoplania and with suppress prostaglandin E 2(PGE 2) biosynthesis etc. relevant.
[function] clearing away heat and cooling blood, promoting blood circulation to remove blood stasis.
[curing mainly] carbuncle sore tumefacting virus, fall and flutter the pain of injury, rheumatism pyretic arthralgia.
29. Fructus Capsicis
Chinese medicine voluminous dictionary is recorded, and Fructus Capsici has:
[function] warming spleen and stomach for dispelling cold.
[curing mainly] rheumatalgia.
30. Rhizoma Atractylodis
Chinese medicine voluminous dictionary is recorded, Rhizoma Atractylodis have antibacterial, antivirus action.
[pharmacology] antibiosis and antiviral functions: Rhizoma Atractylodis are to tulase, staphylococcus aureus, escherichia coli, dead leaf bacillus and Pseudomonas aeruginosa have obvious sterilization functions.Atractylodes japonica has slight inhibitory action to HIV-1 virus recombiant protein enzyme.In Atractylodes lancea (Thunb.) DC., levan acid has obvious preventive effect to the mice of white yeast infection, can extend the mouse survival time.
[function] wind-damp dispelling.
[curing mainly] heavy sensation of the body pain, arthromyodynia domination of damp pathogen, podomere are ached emphatically.
31. Mentholums
Chinese medicine voluminous dictionary is recorded, and Mentholum has:
[function] aromatic drug, remedium corrigens and carminative.
[curing mainly] can be used for skin or mucosa produces refrigerant sense to alleviate discomfort and pain.
32. methyl salicylate
Chinese Pharmacopoeia is recorded, and methyl salicylate has:
[function] treatment soft tissue injury.
[curing mainly] acute joint pain, lumbago, myalgia, neuralgia, sprain, dampen.
33. Eupolyphaga Seu Steleophagas
Chinese Pharmacopoeia is recorded, and Eupolyphaga Seu Steleophaga has:
[function] removing blood stasis with potent drugs blood, reuniting the fractured tendons and bones.
[curing mainly] injured bone, blood stasis amenorrhea, lump in the abdomen mass in the abdomen
34. Rhizoma Pinelliae
Chinese medicine voluminous dictionary is recorded, and Rhizoma Pinelliae has
[function] many externals.
[curing mainly] is take reducing swelling and alleviating pain as main.
35. Flos Carthamis
Chinese medicine voluminous dictionary is recorded, and Flos Carthami has immunocompetence and antiinflammatory action.
[pharmacology] immunocompetence and antiinflammatory action: Carthamus yellow lowers serum lysozyme content, peritoneal macrophage and whole blood phagocytic activity of leukocytes; Plaque forming cells (PFC), spleen specificity rosette forming cell (SRFC) and antibody are produced to be reduced; Suppress suppressor T cell (Ts) cell activation of delayed hypersensitivity (DHA) and super suitable dosage immunization (SOD) induction.External, Carthamus yellow inhibition [ 3h] the TdR T, bone-marrow-derived lymphocyte that infiltrate transform, mixed lymphocytes (MLC) reaction, the generation of interleukin-2 (IL-2) is extremely active.Flos Carthami injection subcutaneous injection can improve the positive percentage that the acid α-naphthyl acetate esterase of Peripheral Lymphocytes of Rat (ANAE) detects.The foot swelling of lumbar injection Carthamus yellow PARA FORMALDEHYDE PRILLS(91,95), the capillary permeability that histamine causes increases and granuloma induced by implantation of cotton pellets bulging Cheng Jun has obvious inhibitory action.Effective content of anti inflammation is also containing Palmic acid, myristic acid, lauric acid etc.
[function] promoting blood circulation to remove obstruction in the collateral, stasis-dispelling and pain-killing.
[curing mainly] traumatic injury, arthralgia, apoplectic hemiplegia.
36. Camphoras
Chinese medicine voluminous dictionary is recorded, and Camphora has local action.
[pharmacology] local action
Camphora belongs to excitants, embrocates skin and can make rubefacient.Can produce the refrigerant sense of similar Herba Menthae if embrocate gently, this is the effect that stimulates Cold receptor; Firmly embrocate and make skin rubefaction.It also has slight local anesthesia effect, and embrocating skin can have feeling of numbness thereupon.Have antipruritic and analgesic activity with camphorated oil clinically, oral have wind dispelling and a slight phlegm-dispelling functions.
[function] reducing swelling and alleviating pain.
[curing mainly] traumatic pain.
The pharmacology of each crude drug in the present invention and drug effect are summed up as shown in table 1.
Figure 2014101238939100002DEST_PATH_IMAGE001
dissipating blood stasis analgesic therapy, promoting blood circulation to remove obstruction in the collateral, stasis-dispelling and pain-killing:
Sanguis Draxonis in medicine, Herba speranskiae tuberculatae, Herba Lycopodii, Caulis Spatholobi, Myrrha, Olibanum, Flos Carthami, Semen Persicae, Radix Angelicae Sinensis, the analgesic therapy of Herba Schizonepetae energy dissipating blood stasis, promoting blood circulation to remove obstruction in the collateral, stasis-dispelling and pain-killing, nourishing blood to restore normal menstruation, effective ingredient has to invigorate blood circulation and can improve the hypercoagulability of blood, blood circulation promoting and organism metabolism, local silt piece is swollen and ache and disperse or disappear, ease the pain.
clearing away heat and cooling blood, blood stasis dispelling removing toxic substances:
Cortex Moutan in medicine, Radix Et Rhizoma Nardostachyos, Radix Et Rhizoma Rhei, Rhizoma Coptidis, Flos Caryophylli, Rhizoma Atractylodis energy clearing away heat and cooling blood, blood stasis dispelling removing toxic substances, effective ingredient has by the three warmers excess-fire of removing heat by catharsis, cleanse the heat of internal organs, let out fiery relieving constipation, adjust the function of body, get through diaphoresis, urinate and the three large toxin expelling paths such as relieving constipation, in comprehensive removing summer-heat blood, gastrointestinal tract and vivotoxin.
warming spleen and stomach for dispelling cold, recuperating depleted YANG is promoted blood circulation:
Rhizoma Zingiberis in medicine, Rhizoma Kaempferiae, Fructus Piperis, Fructus Capsici energy warming spleen and stomach for dispelling cold, recuperating depleted YANG is promoted blood circulation, and effective ingredient has recuperating the depleted YANG to cure collapse-syndrome as emergency treatment, and the raw arteries and veins of QI invigorating is adjusted the function of body, is medicine warming middle-Jiao and tonifying deficiency, the spleen strengthening and damp drying effect.
expelling wind and dampness, wind-damp dispelling, sharp joint understand things pain-stopping:
The Radix Angelicae Dahuricae in medicine, Radix Saposhnikoviae, Radix Clematidis, Pheretima, Cortex Periplocae, Ramulus Cinnamomi, Flos Magnoliae, Rhizoma Et Radix Notopterygii, Rhizoma Chuanxiong, Radix Angelicae Pubescentis energy expelling wind and dampness, wind-damp dispelling, profit joint understand things pain-stopping, effective ingredient has eliminating evil wind prevailing over dampness disease, the cave key of getting round by bribery, pain relieving, the function of adjustment body.
logical all keys, loose stagnated fire, reducing swelling and alleviating pain:
Borneolum Syntheticum in medicine, the logical all keys of Herba Menthae brain-capacity, loose stagnated fire, reducing swelling and alleviating pain effective ingredient have logical nine orifices, distribute stagnated fire and reach the effect of eliminating swelling pain relieving.
removing blood stasis with potent drugs blood, reuniting the fractured tendons and bones:
eupolyphaga Seu Steleophaga in medicine can break congestion, and reuniting the fractured tendons and bones effective ingredient has treatment injured bone, the effect of congestion amenorrhea, and blood circulation promoting and organism metabolism, swell and ache soon local silt and disperse or disappear, and eases the pain, and promotes recovery from illness.
A kind of relieving pain and activating blood circulation relaxing muscles and tendons plaster, described relieving pain and activating blood circulation relaxing muscles and tendons plaster comprises according to mass percent: Rhizoma Zingiberis 0.1%-30%, Rhizoma Kaempferiae 0.1%-20%, Radix Angelicae Dahuricae 0.1%-20%, Radix Et Rhizoma Nardostachyos 0.1%-15%, Radix Et Rhizoma Rhei 0.1%-15%, Radix Saposhnikoviae 0.1%-10%, Radix Clematidis 0.1%-10%, Pheretima 0.1%-10%, Sanguis Draxonis 0.1%-10%, Rhizoma Coptidis 0.1%-10%, Herba speranskiae tuberculatae 0.1%-10%, Herba Lycopodii 0.1%-10%, Caulis Spatholobi 0.1%-10%, Myrrha 0.1%-10%, Olibanum 0.1%-10%, Borneolum Syntheticum 0.1%-10%, Semen Persicae 0.1%-10%, Radix Angelicae Sinensis 0.1%-10%, Flos Caryophylli 0.1%-10%, Fructus Piperis 0.1%-10%, Cortex Periplocae 0.1%-10%, Herba Schizonepetae 0.1%-10%, Ramulus Cinnamomi 0.1%-10%, Flos Magnoliae 0.1%-10%, Rhizoma Et Radix Notopterygii 0.1%-10%, Rhizoma Chuanxiong 0.1%-10%, Radix Angelicae Pubescentis 0.1%-10%, Cortex Moutan 0.1%-10%, Fructus Capsici 0.1%-10%, Rhizoma Atractylodis 0.1%-10%, Mentholum 0.1%-10%, methyl salicylate 0.1%-15%, Eupolyphaga Seu Steleophaga 0.1%-10%, Rhizoma Pinelliae 0.1%-15%, Flos Carthami 0.1%-10%, Camphora 0.1%-10%.
Preferably, described relieving pain and activating blood circulation relaxing muscles and tendons plaster comprises Rhizoma Zingiberis 0.25%-25% according to mass percent, Rhizoma Kaempferiae 0.25%-15%, Radix Angelicae Dahuricae 0.25%-15%, Radix Et Rhizoma Nardostachyos 0.25%-10%, Radix Et Rhizoma Rhei 0.25%-10%, Radix Saposhnikoviae 0.25%-9%, Radix Clematidis 0.25%-9%, Pheretima 0.25%-9%, Sanguis Draxonis 0.25%-9%, Rhizoma Coptidis 0.25%-9%, Herba speranskiae tuberculatae 0.25%-9%, Herba Lycopodii 0.25%-9%, Caulis Spatholobi 0.25%-9%, Myrrha 0.25%-9%, Olibanum 0.25%-9%, Borneolum Syntheticum 0.25%-9%, Semen Persicae 0.25%-9%, Radix Angelicae Sinensis 0.25%-9%, Flos Caryophylli 0.25%-9%, Fructus Piperis 0.25%-9%, Cortex Periplocae 0.25%-9%, Herba Schizonepetae 0.25%-9%, Ramulus Cinnamomi 0.25%-9%, Flos Magnoliae 0.25%-9%, Rhizoma Et Radix Notopterygii 0.25%-9%, Rhizoma Chuanxiong 0.25%-9%, Radix Angelicae Pubescentis 0.25%-9%, Cortex Moutan 0.25%-9%, Fructus Capsici 0.25%-9%, Rhizoma Atractylodis 0.25%-9%, Mentholum 0.25%-9%, methyl salicylate 0.25%-10%, Eupolyphaga Seu Steleophaga 0.25%-10%, Rhizoma Pinelliae 0.25%-10.5%, Flos Carthami 0.25%-9%, Camphora 0.25%-9%.
Preferably, described relieving pain and activating blood circulation relaxing muscles and tendons plaster comprises according to mass percent: Rhizoma Zingiberis 2%-20%, Rhizoma Kaempferiae 1%-10%, Radix Angelicae Dahuricae 1%-10%, Radix Et Rhizoma Nardostachyos 0.5%-10%, Radix Et Rhizoma Rhei 0.5%-10%, Radix Saposhnikoviae 0.5%-8%, Radix Clematidis 0.5%-8%, Pheretima 0.5%-8%, Sanguis Draxonis 0.5%-8%, Rhizoma Coptidis 0.5%-8%, Herba speranskiae tuberculatae 0.5%-8%, Herba Lycopodii 0.5%-8%, Caulis Spatholobi 0.5%-8%, Myrrha 0.5%-8%, Olibanum 0.5%-8%, Borneolum Syntheticum 0.5%-8%, Semen Persicae 0.5%-8%, Radix Angelicae Sinensis 0.5%-8%, Flos Caryophylli 0.5%-8%, Fructus Piperis 0.5%-8%, Cortex Periplocae 0.5%-8%, Herba Schizonepetae 0.5%-8%, Ramulus Cinnamomi 0.5%-8%, Flos Magnoliae 0.5%-8%, Rhizoma Et Radix Notopterygii 0.5%-8%, Rhizoma Chuanxiong 0.5%-8%, Radix Angelicae Pubescentis 0.5%-8%, Cortex Moutan 0.5%-8%, Fructus Capsici 0.5%-8%, Rhizoma Atractylodis 0.5%-8%, Mentholum 0.5%-8%, methyl salicylate 0.5%-10%, Eupolyphaga Seu Steleophaga 0.5%-9%, Rhizoma Pinelliae 0.5%-10%, Flos Carthami 0.5%-8%, Camphora 0.5%-8%.
Preferably, described relieving pain and activating blood circulation relaxing muscles and tendons plaster comprises according to mass percent: Rhizoma Zingiberis 5%-15%, Rhizoma Kaempferiae 2%-10%, Radix Angelicae Dahuricae 2%-10%, Radix Et Rhizoma Nardostachyos 2%-8%, Radix Et Rhizoma Rhei 2%-8%, Radix Saposhnikoviae 0.75%-7%, Radix Clematidis 0.75%-7%, Pheretima 0.75%-7%, Sanguis Draxonis 0.75%-7%, Rhizoma Coptidis 0.75%-7%, Herba speranskiae tuberculatae 0.75%-7%, Herba Lycopodii 0.75%-7%, Caulis Spatholobi 0.75%-7%, Myrrha 0.75%-7%, Olibanum 0.75%-7%, Borneolum Syntheticum 0.75%-7%, Semen Persicae 0.75%-7%, Radix Angelicae Sinensis 0.75%-7%, Flos Caryophylli 0.75%-7%, Fructus Piperis 0.75%-7%, Cortex Periplocae 0.75%-7%, Herba Schizonepetae 0.75%-7%, Ramulus Cinnamomi 0.75%-7%, Flos Magnoliae 0.75%-7%, Rhizoma Et Radix Notopterygii 0.75%-7%, Rhizoma Chuanxiong 0.75%-7%, Radix Angelicae Pubescentis 0.75%-7%, Cortex Moutan 0.75%-7%, Fructus Capsici 0.75%-7%, Rhizoma Atractylodis 0.75%-7%, Mentholum 0.75%-7%, methyl salicylate 1%-7.5%, Eupolyphaga Seu Steleophaga 1%-8.5%, Rhizoma Pinelliae 2.5%-7%, Flos Carthami 0.75%-7%, Camphora 0.75%-7%.
Preferably, described relieving pain and activating blood circulation relaxing muscles and tendons plaster comprises according to mass percent: Rhizoma Zingiberis 7%-10%, Rhizoma Kaempferiae 3%-8%, Radix Angelicae Dahuricae 3%-8%, Radix Et Rhizoma Nardostachyos 3%-6%, Radix Et Rhizoma Rhei 3%-6%, Radix Saposhnikoviae 1%-5%, Radix Clematidis 1%-5%, Pheretima 1%-5%, Sanguis Draxonis 1%-5%, Rhizoma Coptidis 1%-5%, Herba speranskiae tuberculatae 1%-5%, Herba Lycopodii 1%-5%, Caulis Spatholobi 1%-5%, Myrrha 1%-5%, Olibanum 1%-5%, Borneolum Syntheticum 1%-5%, Semen Persicae 1%-5%, Radix Angelicae Sinensis 1%-5%, Flos Caryophylli 1%-5%, Fructus Piperis 1%-5%, Cortex Periplocae 1%-5%, Herba Schizonepetae 1%-5%, Ramulus Cinnamomi 1%-5%, Flos Magnoliae 1%-5%, Rhizoma Et Radix Notopterygii 1%-5%, Rhizoma Chuanxiong 1%-5%, Radix Angelicae Pubescentis 1%-5%, Cortex Moutan 1%-5%, Fructus Capsici 1%-5%, Rhizoma Atractylodis 1%-5%, Mentholum 1%-5%, methyl salicylate 2%-5%, Eupolyphaga Seu Steleophaga 2%-7.5%, Rhizoma Pinelliae 3.5%-5%, Flos Carthami 1%-5%, Camphora 1%-5%.
Preferably, described relieving pain and activating blood circulation relaxing muscles and tendons plaster comprises according to mass percent: Rhizoma Zingiberis 9%-10%, Rhizoma Kaempferiae 4%-6%, Radix Angelicae Dahuricae 4%-6%, Radix Et Rhizoma Nardostachyos 4%-6%, Radix Et Rhizoma Rhei 4%-6%, Radix Saposhnikoviae 1%-2%, Radix Clematidis 1%-2%, Pheretima 1%-2%, Sanguis Draxonis 1%-2%, Rhizoma Coptidis 1%-2%, Herba speranskiae tuberculatae 2%-3%, Herba Lycopodii 2%-3%, Caulis Spatholobi 3%-4%, Myrrha 1%-2%, Olibanum 1%-2%, Borneolum Syntheticum 2%-3%, Semen Persicae 1%-2%, Radix Angelicae Sinensis 3%-4%, Flos Caryophylli 3%-4%, Fructus Piperis 3%-4%, Cortex Periplocae 2%-3%, Herba Schizonepetae 2%-3%, Ramulus Cinnamomi 2%-3%, Flos Magnoliae 1%-2%, Rhizoma Et Radix Notopterygii 2%-3%, Rhizoma Chuanxiong 1%-2%, Radix Angelicae Pubescentis 1%-2%, Cortex Moutan 1%-2%, Fructus Capsici 1%-2%, Rhizoma Atractylodis 1%-2%, Mentholum 2%-3%, methyl salicylate 3%-4%, Eupolyphaga Seu Steleophaga 3%-4%, Rhizoma Pinelliae 4%-5%, Flos Carthami 3%-4%, Camphora 2%-3%.
Preferably, described relieving pain and activating blood circulation relaxing muscles and tendons plaster comprises according to mass percent: Rhizoma Zingiberis 9.756%, Rhizoma Kaempferiae 5.488%, the Radix Angelicae Dahuricae 5.488%, Radix Et Rhizoma Nardostachyos 4.878%, Radix Et Rhizoma Rhei 4.878%, Radix Saposhnikoviae 1.829%, Radix Clematidis 1.829%, Pheretima 1.22%, Sanguis Draxonis 1.829%, Rhizoma Coptidis 1.22%, Herba speranskiae tuberculatae 2.439%, Herba Lycopodii 2.439%, Caulis Spatholobi 3.049%, Myrrha 1.22%, Olibanum 1.22%, Borneolum Syntheticum 2.439%, Semen Persicae 1.22%, Radix Angelicae Sinensis 3.049%, Flos Caryophylli 3.049%, Fructus Piperis 3.049%, Cortex Periplocae 2.439%, Herba Schizonepetae 2.439%, Ramulus Cinnamomi 2.439%, Flos Magnoliae 1.829%, Rhizoma Et Radix Notopterygii 2.439%, Rhizoma Chuanxiong 1.829%, Radix Angelicae Pubescentis 1.829%, Cortex Moutan 1.22%, Fructus Capsici 1.22%, Rhizoma Atractylodis 1.22%, Mentholum 2.439%, methyl salicylate 3.659%, Eupolyphaga Seu Steleophaga 3.049%, Rhizoma Pinelliae 4.878%, Flos Carthami 3.049%, Camphora 2.439%.
The preparation method that the invention provides described a kind of relieving pain and activating blood circulation relaxing muscles and tendons plaster, comprises the following steps:
Step (1), under aseptic, dustless condition, natural Chinese medicinal herb Rhizoma Zingiberis, Rhizoma Kaempferiae, the Radix Angelicae Dahuricae, Radix Et Rhizoma Nardostachyos, Radix Et Rhizoma Rhei, Radix Saposhnikoviae, Radix Clematidis, Pheretima, Sanguis Draxonis, Rhizoma Coptidis, Herba speranskiae tuberculatae, Herba Lycopodii, Caulis Spatholobi, Myrrha, Olibanum, Borneolum Syntheticum, Semen Persicae, Radix Angelicae Sinensis, Flos Caryophylli, Fructus Piperis, Cortex Periplocae, Herba Schizonepetae, Ramulus Cinnamomi, Flos Magnoliae, Rhizoma Et Radix Notopterygii, Rhizoma Chuanxiong, Radix Angelicae Pubescentis, Cortex Moutan, Fructus Capsici, Rhizoma Atractylodis, Mentholum, Eupolyphaga Seu Steleophaga, Rhizoma Pinelliae, Flos Carthami, Camphora are cleaned;
Step (2), is broken into coarse powder by the Radix Angelicae Dahuricae, Radix Et Rhizoma Nardostachyos, Radix Et Rhizoma Rhei, Radix Saposhnikoviae, Radix Clematidis, Pheretima, Sanguis Draxonis, Rhizoma Coptidis, Herba speranskiae tuberculatae, Herba Lycopodii, Caulis Spatholobi, Myrrha, Olibanum, Semen Persicae, Radix Angelicae Sinensis, Flos Caryophylli, Cortex Periplocae, Herba Schizonepetae, Ramulus Cinnamomi, Flos Magnoliae, Rhizoma Et Radix Notopterygii, Rhizoma Chuanxiong, Radix Angelicae Pubescentis, Cortex Moutan, Fructus Capsici, Rhizoma Atractylodis, Eupolyphaga Seu Steleophaga, Rhizoma Pinelliae, Flos Carthami powder;
Step (3), puts into tank body by the coarse powder of step (2) gained, with yellow wine immersion 20-48 hour; Then to 40-60 degrees Celsius of tank body Steam Heating, heat time heating time 10-24 hour;
Step (4) as solvent, is constantly added solvent with the ethanol of volume ratio 70% in the coarse powder of step (3) gained, makes solvent infiltrate coarse powder, carries out percolation, collects the liquid of filtering, and the liquid of filtering is condensed into relative density and is about 1.03 clear paste;
Step (5), crosses 120 object sieves by Rhizoma Zingiberis, Rhizoma Kaempferiae, Fructus Piperis powder process, then together joins in the clear paste of step (4) gained with methyl salicylate, Mentholum, the Camphora of Borneolum Syntheticum, 98% concentration, stirs; And then the substrate that adds 4～4.5 times of weight to be made by vaseline, zinc oxide, Colophonium, make coating; Then be coated with cream, cutting, lid lining, section, obtain final product.
Preferably, in described step (3), with yellow wine immersion 48 hours, to 60 degrees Celsius of tank body Steam Heating, 24 hours heat time heating times.
To bone matrix hyperplasia, the treatment of bones and muscles pain and arthralgia is that faster pain relieving is better, and relieving pain and activating blood circulation relaxing muscles and tendons plaster provided by the present invention is that muscles and bones and joint are regulated comprehensively, makes the blood vessels of whole body unimpeded by blood circulation promoting and blood stasis dispelling.Be tending towards normal slowly process by the thoughtful each skeleton muscle of the human body arteries and veins of the rigid muscle arteries and veins of original sclerotin, particularly to internal recycle also clearly.Relieving pain and activating blood circulation relaxing muscles and tendons plaster is to adjust the each skeleton muscle of human body arteries and veins ideal medicament, is person in middle and old age's bones and muscles pain, bone matrix hyperplasia, the good medicine of one of muscular paralysis and arthralgia.Bone matrix hyperplasia, bones and muscles pain, muscular paralysis and arthralgia patient paste with after 2-3 the course for the treatment of of relieving pain and activating blood circulation relaxing muscles and tendons plaster, be 8 subsides 1 course for the treatment of, what reparation human body was impaired respectively organizes muscle arteries and veins, progressively control the pathogenesis of skeleton muscle arteries and veins, mediator's somatic nervous system, blood circulation promoting plays and coordinates and Comprehensive Treatment function in pain relieving is active, fundamentally thoroughly reverse skeleton muscle arteries and veins pathogenesis, make health reach rehabilitation.
Relieving pain and activating blood circulation relaxing muscles and tendons plaster has: (1) treating both the principal and secondary aspects of a disease.It breaks through traditional treatment limitation, and this medicine, in treatment bone matrix hyperplasia, bones and muscles pain, muscular paralysis and arthralgia, can suppress the pathological changes of the important internal organs such as nerve system of human body, blood circulation to greatest extent; (2) many medicine comprehensive improvements tactics of breaking the normal procedure, it is with multi-medicament, fiercely assault improves for blood circulation, corrects equilibrium between yin and yang, removes smooth muscle spasm, and skeleton muscle arteries and veins is transformed to rehabilitation; (3) thorough alleviating pain.Relaxing muscles and tendons and activating QI and blood in the collateral, invigorates blood circulation, and when the bioactive molecule in Gene regulation and plant in medicine enters after human body, activates and regulate internal circulation system, makes it be tending towards normal.Paste 1-2 the course for the treatment of, pain disappears, and muscle arteries and veins all can reach normally, and is consolidated, and makes in health status.
From above technical scheme provided by the invention, the present invention has following technique effect:
Traditional Chinese medical science plaster plastering therapy is with a long history in China.Along with ancient Chinese medicine doctor sequential use development, it is simple, quickly alleviating pain, safe and reliable, to reduce the advantages such as misery, fast track rehabilitation be more to show.Relieving pain and activating blood circulation relaxing muscles and tendons plaster adopts rare medicinal herbs to concoct and modern crafts making through Gu, with the obvious advantage to bone matrix hyperplasia, bones and muscles pain and arthralgia: relieving pain and activating blood circulation relaxing muscles and tendons plaster is take rubber-emplastrum as carrier, act on external treatment with Chinese medicine theory, selected multiple rare Chinese medicine, directly external application focus, realize logical blood, regulating QI, removing blood stasis, pain relieving, get rid of evils, many effects such as righting, realize comprehensive therapeutic effect, bone matrix hyperplasia, bones and muscles pain and arthralgia are thoroughly removed to misery.
Relieving pain and activating blood circulation relaxing muscles and tendons plaster is sticked in sufferer skin zone while use, form the sealing state that is difficult to evaporation and diffusion in part, impel skin space between skin and muscles penetrating with the medicine of having one's ideas straightened out, can form in part the advantage of concentrating medication, through focus, makes the active ingredient of medicine coalescent in affected tissue, and irritates by Transdermal absorption and meridians, dredging the meridian, gets through blood vessels.Improve surrounding tissue nutrition, to reach pain relieving, detumescence and the effect of repairing pathological tissues.
Relieving pain and activating blood circulation relaxing muscles and tendons plaster is followed the theory of external treatment of Chinese medicine and is rationally organized medicine, and using method is simple, and therapeutic process is without any armarium, and patient can treat completely voluntarily, does not affect normal work, life, embodies the strange feature of Chinese medicine letter effect.Every note plaster can be with 2 days, the lasting osmosis of medicine are protected, lasting medicine.
Relieving pain and activating blood circulation relaxing muscles and tendons plaster provided by the present invention has good anti-inflammatory and antalgic and function of promoting blood circulation to disperse blood clots, not only can thoroughly alleviate bone matrix hyperplasia, bones and muscles pain and arthralgia, but also to subcutaneous nodule, particularly better to muscular paralysis curative effect.
The specific embodiment
In order to make those skilled in the art person understand better the present invention program, below the present invention is described in further detail:
Percolation is that the medical material that appropriateness is pulverized is put in percolator, constantly adds solvent by top, leaches the method for medicinal ingredient in the moving process of solvent infiltrate medical material sulfate layer flows downhill.Percolation belongs to Dynamic Leaching method, and solvent utilization rate is high, and effective ingredient leaches completely, can directly collect leachate.Be applicable to valuable medicinal, toxicity medical material and high concentrate formulation; Also can be used for the medicinal material extract that active constituent content is lower.But the medical material to fresh and expansive medical material, inorganization structure should not be selected.Ethanol or the Chinese liquor of the conventional variable concentrations of this method make solvent, therefore should prevent the volatilization loss of solvent.
Single percolation: mean the normal pressure percolation method with a percolator, operating process comprises:
1. grinding medicinal materials: degree of grinding should be suitable, is generally advisable with coarse powder or coarse powder.Meticulous easy obstruction; Cross the thick compression that is difficult for, solvent-oil ratio is large, and leaching effect is poor.2. moistening medicated powder: medicated powder should, first with appropriate extraction solvent moistening, make it abundant expansion, avoids expanding and resulting in blockage at percolator Chinese medicine powder.3. medicated powder fitted tube: the end the suitable filter material of place mat are tried to give a false impression in percolator bottom, packs the medicated powder gradation that moistening is expanded into percolator, answers degree of tightness suitable, evenly flattens, and filter paper or gauze cover for top, and add a small amount of weight, in case medicated powder floats when solubilizer.4. get rid of bubble: open the piston of percolate outlet, add solvent flow out from outlet to percolate from medicated powder top, several centimetres, solvent submergence medicated powder surface, closes percolate outlet.5. medicated powder dipping: generally carry stain 24～48h, make the abundant diffusion of solvent.6. percolation: open percolate outlet and receive the liquid of filtering, the liquid rate of outflow of filtering is calculated with 1000g medical material, conventionally continuous supplementing solvent in 1～3ml. percolation process per minute.Make solvent submergence medicated powder all the time.
What the present invention taked is exactly single percolation.
The product that methyl salicylate adopts Shanghai Yi Ji Industrial Co., Ltd. to produce, concentration 98%.
Relative density definition: relative density means under common specific condition, the ratio of the density of something and the density of water.Except as otherwise herein provided, temperature is 20 ℃.When with 1g/cm 3as with reference to density, density when 4 ℃, water, is called proportion in the past.
Relative density determination method: some medicine has certain relative density.Purity changes, and relative density is also in company with changing.Measure relative density, can distinguish or check the pure assorted degree of medicine.The relative density of liquid drug, generally measures with density bottle; While measuring the relative density of volatile liquid, available Webster bydrostatic balance is measured.
Pycnometric method: get cleaning, the dry also density bottle of accurately weighed weight, fill test sample, temperature should be lower than the temperature stipulating under 20 ℃ or each medicine item, then load onto thermometer, should be without bubble in bottle, put in the water-bath of the temperature stipulating under 20 ℃ or each medicine item and place 10--20 minute, make the temperature of content reach the temperature stipulating under 20 ℃ or each medicine item, remove the liquid that overflows side pipe with filter paper, cover immediately cover.Then density bottle is taken out in water-bath, with filter paper, the outside of density bottle is dried again, accurately weighed, deduct the weight of density bottle, try to achieve after the weight of test sample, test sample is inclined, clean density bottle, fill the cold water newly boiling, then the weight of water while recording same temperature according to upper method, be calculated as follows, obtain final product.
Below formula:
Test sample weight=be equipped with density bottle-density bottle own wt of test sample
The weight of water=be equipped with density bottle-density bottle own wt of water
Relative density=test sample weight/water weight of test sample.
To the present invention be described in more detail by embodiment below:
embodiment 1
Step (1), aseptic, under dustless condition, by 30 grams of natural Chinese medicinal herb Rhizoma Zingiberiss, 20 grams of Rhizoma Kaempferiaes, 20 grams of the Radixs Angelicae Dahuricae, 15 grams of Radix Et Rhizoma Nardostachyos, 0.1 gram of Radix Et Rhizoma Rhei, 10 grams of Radix Saposhnikoviaes, 0.1 gram of Radix Clematidis, 0.1 gram of Pheretima, 0.1 gram of Sanguis Draxonis, 0.1 gram of Rhizoma Coptidis, 0.1 gram of Herba speranskiae tuberculatae, 0.1 gram of Herba Lycopodii, 0.1 gram of Caulis Spatholobi, 0.1 gram of Myrrha, 0.1 gram of Olibanum, 0.1 gram of Borneolum Syntheticum, 0.1 gram, Semen Persicae, 0.1 gram of Radix Angelicae Sinensis, 0.1 gram of Flos Caryophylli, 0.1 gram, Fructus Piperis, 0.1 gram of Cortex Periplocae, 0.1 gram of Herba Schizonepetae, 0.1 gram of Ramulus Cinnamomi, 0.1 gram of Flos Magnoliae, 0.1 gram of Rhizoma Et Radix Notopterygii, 0.1 gram of Rhizoma Chuanxiong, 0.1 gram of Radix Angelicae Pubescentis, 0.1 gram of Cortex Moutan, 0.1 gram, Fructus Capsici, 0.1 gram of Rhizoma Atractylodis, 0.1 gram of Mentholum, 0.1 gram of Eupolyphaga Seu Steleophaga, 0.1 gram of Rhizoma Pinelliae, 0.1 gram, Flos Carthami, 2 grams of cleanings of Camphora,
Step (2), by 20 grams of the Radixs Angelicae Dahuricae, 15 grams of Radix Et Rhizoma Nardostachyos, 0.1 gram of Radix Et Rhizoma Rhei, 10 grams of Radix Saposhnikoviaes, 0.1 gram of Radix Clematidis, 0.1 gram of Pheretima, 0.1 gram of Sanguis Draxonis, 0.1 gram of Rhizoma Coptidis, 0.1 gram of Herba speranskiae tuberculatae, 0.1 gram of Herba Lycopodii, 0.1 gram of Caulis Spatholobi, 0.1 gram of Myrrha, 0.1 gram of Olibanum, 0.1 gram, Semen Persicae, 0.1 gram of Radix Angelicae Sinensis, 0.1 gram of Flos Caryophylli, 0.1 gram of Cortex Periplocae, 0.1 gram of Herba Schizonepetae, 0.1 gram of Ramulus Cinnamomi, 0.1 gram of Flos Magnoliae, 0.1 gram of Rhizoma Et Radix Notopterygii, 0.1 gram of Rhizoma Chuanxiong, 0.1 gram of Radix Angelicae Pubescentis, 0.1 gram of Cortex Moutan, 0.1 gram, Fructus Capsici, 0.1 gram of Rhizoma Atractylodis, 0.1 gram of Eupolyphaga Seu Steleophaga, 0.1 gram of Rhizoma Pinelliae, 0.1 gram of Flos Carthami powder is broken into coarse powder,
Step (3), put into tank body by the coarse powder of step (2) gained, with yellow wine immersion 20 hours; Then to 40 degrees Celsius of tank body Steam Heating, 10 hours heat time heating times;
Step (4) as solvent, is constantly added solvent with the ethanol of volume ratio 70% in the coarse powder of step (3) gained, makes solvent infiltrate coarse powder, carries out percolation, collects the liquid of filtering, and the liquid of filtering is condensed into relative density and is about 1.03 clear paste;
Step (5), 30 grams of Rhizoma Zingiberiss, 20 grams of Rhizoma Kaempferiaes, Fructus Piperis 0.1 are restrained to powder and cross 120 object sieves, then together join in the clear paste of step (4) gained with 2 grams of 0.1 gram of 0.1 gram of methyl salicylate, Mentholum, the Camphoras of 0.1 gram of Borneolum Syntheticum, concentration 98%, stir; And then the substrate that adds 4～4.5 times of weight to be made by vaseline, zinc oxide, Colophonium, make coating; Then be coated with cream, cutting, lid lining, section, obtain product 1.
embodiment 2
0.1 gram of Rhizoma Zingiberis, 0.1 gram of Rhizoma Kaempferiae, 0.1 gram of the Radix Angelicae Dahuricae, 0.1 gram of Radix Et Rhizoma Nardostachyos, 15 grams of Radix Et Rhizoma Rhei, 0.1 gram of Radix Saposhnikoviae, 10 grams of Radix Clematidis, 10 grams of Pheretimas, 10 grams of Sanguis Draxonis, 10 grams of Rhizoma Coptidis, 10 grams of Herba speranskiae tuberculataes, 10 grams of Herba Lycopodiis, 10 grams of Caulis Spatholobis, 10 grams of Myrrhas, 0.1 gram of Olibanum, 0.1 gram of Borneolum Syntheticum, 0.1 gram, Semen Persicae, 0.1 gram of Radix Angelicae Sinensis, 0.1 gram of Flos Caryophylli, 0.1 gram, Fructus Piperis, 0.1 gram of Cortex Periplocae, 0.1 gram of Herba Schizonepetae, 0.1 gram of Ramulus Cinnamomi, 0.1 gram of Flos Magnoliae, 0.1 gram of Rhizoma Et Radix Notopterygii, 0.1 gram of Rhizoma Chuanxiong, 0.1 gram of Radix Angelicae Pubescentis, 0.1 gram of Cortex Moutan, 0.1 gram, Fructus Capsici, 0.1 gram of Rhizoma Atractylodis, 0.1 gram of Mentholum, 0.1 gram of methyl salicylate, 0.1 gram of Eupolyphaga Seu Steleophaga, 0.1 gram of Rhizoma Pinelliae, 2.4 grams, Flos Carthami, 0.1 gram of Camphora.
With yellow wine immersion 21 hours; To 41 degrees Celsius of tank body Steam Heating, 10.5 hours heat time heating times.All the other are with embodiment 1, products obtained therefrom 2.
embodiment 3
0.1 gram of Rhizoma Zingiberis, 0.1 gram of Rhizoma Kaempferiae, 0.1 gram of the Radix Angelicae Dahuricae, 0.1 gram of Radix Et Rhizoma Nardostachyos, 0.1 gram of Radix Et Rhizoma Rhei, 0.1 gram of Radix Saposhnikoviae, 0.1 gram of Radix Clematidis, 0.1 gram of Pheretima, 0.1 gram of Sanguis Draxonis, 0.1 gram of Rhizoma Coptidis, 0.1 gram of Herba speranskiae tuberculatae, 0.1 gram of Herba Lycopodii, 0.1 gram of Caulis Spatholobi, 0.1 gram of Myrrha, 10 grams of Olibanums, 10 grams of Borneolum Syntheticums, 10 grams, Semen Persicae, 10 grams of Radix Angelicae Sinensis, 10 grams of Flos Caryophyllis, 10 grams, Fructus Piperis, 10 grams of Cortex Periplocaes, 10 grams of Herba Schizonepetae, 10 grams of Ramulus Cinnamomi, 0.1 gram of Flos Magnoliae, 0.1 gram of Rhizoma Et Radix Notopterygii, 0.1 gram of Rhizoma Chuanxiong, 0.1 gram of Radix Angelicae Pubescentis, 0.1 gram of Cortex Moutan, 0.1 gram, Fructus Capsici, 0.1 gram of Rhizoma Atractylodis, 0.1 gram of Mentholum, 0.1 gram of methyl salicylate, 0.1 gram of Eupolyphaga Seu Steleophaga, 7.4 grams of Rhizoma Pinelliae, 0.1 gram, Flos Carthami, 0.1 gram of Camphora.
With yellow wine immersion 22 hours; To 42 degrees Celsius of tank body Steam Heating, 11 hours heat time heating times.All the other are with embodiment 1, products obtained therefrom 3.
embodiment 4
0.1 gram of Rhizoma Zingiberis, 0.1 gram of Rhizoma Kaempferiae, 0.1 gram of the Radix Angelicae Dahuricae, 0.1 gram of Radix Et Rhizoma Nardostachyos, 0.1 gram of Radix Et Rhizoma Rhei, 0.1 gram of Radix Saposhnikoviae, 0.1 gram of Radix Clematidis, 0.1 gram of Pheretima, 0.1 gram of Sanguis Draxonis, 0.1 gram of Rhizoma Coptidis, 0.1 gram of Herba speranskiae tuberculatae, 0.1 gram of Herba Lycopodii, 0.1 gram of Caulis Spatholobi, 0.1 gram of Myrrha, 0.1 gram of Olibanum, 0.1 gram of Borneolum Syntheticum, 0.1 gram, Semen Persicae, 0.1 gram of Radix Angelicae Sinensis, 0.1 gram of Flos Caryophylli, 0.1 gram, Fructus Piperis, 0.1 gram of Cortex Periplocae, 0.1 gram of Herba Schizonepetae, 0.1 gram of Ramulus Cinnamomi, 10 grams of Flos Magnoliaes, 10 grams of Rhizoma Et Radix Notopterygiis, 10 grams of Rhizoma Chuanxiongs, 10 grams of Radix Angelicae Pubescentiss, 10 grams of Cortex Moutans, 10 grams, Fructus Capsici, 10 grams of Rhizoma Atractylodis, 10 grams of Mentholums, 15 grams of methyl salicylate, 2.4 grams of Eupolyphaga Seu Steleophagas, 0.1 gram of Rhizoma Pinelliae, 0.1 gram, Flos Carthami, 0.1 gram of Camphora.
With yellow wine immersion 23 hours; To 43 degrees Celsius of tank body Steam Heating, 11.5 hours heat time heating times.All the other are with embodiment 1, products obtained therefrom 4.
embodiment 5
1.5 grams of Rhizoma Zingiberiss, 1.5 grams of Rhizoma Kaempferiaes, 1.5 grams of the Radixs Angelicae Dahuricae, 1.5 grams of Radix Et Rhizoma Nardostachyos, 1.5 grams of Radix Et Rhizoma Rhei, 1.5 grams of Radix Saposhnikoviaes, 1.5 grams of Radix Clematidis, 1.5 grams of Pheretimas, 1.5 grams of Sanguis Draxonis, 1.5 grams of Rhizoma Coptidis, 1.5 grams of Herba speranskiae tuberculataes, 1.5 grams of Herba Lycopodiis, 1.5 grams of Caulis Spatholobis, 1.5 grams of Myrrhas, 1.5 grams of Olibanums, 1.5 grams of Borneolum Syntheticums, 1.5 grams, Semen Persicae, 1.5 grams of Radix Angelicae Sinensis, 2 grams of Flos Caryophyllis, 2 grams, Fructus Piperis, 2 grams of Cortex Periplocaes, 2 grams of Herba Schizonepetae, 2 grams of Ramulus Cinnamomi, 2 grams of Flos Magnoliaes, 2 grams of Rhizoma Et Radix Notopterygiis, 2 grams of Rhizoma Chuanxiongs, 2 grams of Radix Angelicae Pubescentiss, 2 grams of Cortex Moutans, 2 grams, Fructus Capsici, 2 grams of Rhizoma Atractylodis, 2 grams of Mentholums, 2 grams of methyl salicylate, 10 grams of Eupolyphaga Seu Steleophagas, 15 grams of Rhizoma Pinelliae, 10 grams, Flos Carthami, 10 grams of Camphoras.
With yellow wine immersion 24 hours; To 44 degrees Celsius of tank body Steam Heating, 12 hours heat time heating times.All the other are with embodiment 1, products obtained therefrom 5.
embodiment 6
25 grams of Rhizoma Zingiberiss, 15 grams of Rhizoma Kaempferiaes, 15 grams of the Radixs Angelicae Dahuricae, 10 grams of Radix Et Rhizoma Nardostachyos, 10 grams of Radix Et Rhizoma Rhei, 9 grams of Radix Saposhnikoviaes, 0.25 gram of Radix Clematidis, 0.25 gram of Pheretima, 0.25 gram of Sanguis Draxonis, 0.25 gram of Rhizoma Coptidis, 0.25 gram of Herba speranskiae tuberculatae, 0.25 gram of Herba Lycopodii, 0.25 gram of Caulis Spatholobi, 0.25 gram of Myrrha, 0.25 gram of Olibanum, 0.25 gram of Borneolum Syntheticum, 0.25 gram, Semen Persicae, 0.25 gram of Radix Angelicae Sinensis, 0.25 gram of Flos Caryophylli, 0.25 gram, Fructus Piperis, 0.25 gram of Cortex Periplocae, 0.25 gram of Herba Schizonepetae, 0.25 gram of Ramulus Cinnamomi, 0.25 gram of Flos Magnoliae, 0.25 gram of Rhizoma Et Radix Notopterygii, 0.25 gram of Rhizoma Chuanxiong, 0.25 gram of Radix Angelicae Pubescentis, 0.25 gram of Cortex Moutan, 0.25 gram, Fructus Capsici, 0.25 gram of Rhizoma Atractylodis, 0.25 gram of Mentholum, 0.25 gram of methyl salicylate, 0.25 gram of Eupolyphaga Seu Steleophaga, 0.25 gram of Rhizoma Pinelliae, 0.25 gram, Flos Carthami, 8.75 grams of Camphoras.
With yellow wine immersion 25 hours; To 45 degrees Celsius of tank body Steam Heating, 12.5 hours heat time heating times.All the other are with embodiment 1, products obtained therefrom 6.
embodiment 7
0.25 gram of Rhizoma Zingiberis, 0.25 gram of Rhizoma Kaempferiae, 0.25 gram of the Radix Angelicae Dahuricae, 0.25 gram of Radix Et Rhizoma Nardostachyos, 0.25 gram of Radix Et Rhizoma Rhei, 0.25 gram of Radix Saposhnikoviae, 9 grams of Radix Clematidis, 9 grams of Pheretimas, 9 grams of Sanguis Draxonis, 9 grams of Rhizoma Coptidis, 9 grams of Herba speranskiae tuberculataes, 9 grams of Herba Lycopodiis, 9 grams of Caulis Spatholobis, 9 grams of Myrrhas, 9 grams of Olibanums, 9 grams of Borneolum Syntheticums, 0.5 gram, Semen Persicae, 0.5 gram of Radix Angelicae Sinensis, 0.5 gram of Flos Caryophylli, 0.5 gram, Fructus Piperis, 0.5 gram of Cortex Periplocae, 0.5 gram of Herba Schizonepetae, 0.5 gram of Ramulus Cinnamomi, 0.5 gram of Flos Magnoliae, 0.5 gram of Rhizoma Et Radix Notopterygii, 0.5 gram of Rhizoma Chuanxiong, 0.5 gram of Radix Angelicae Pubescentis, 0.5 gram of Cortex Moutan, 0.5 gram, Fructus Capsici, 0.5 gram of Rhizoma Atractylodis, 0.25 gram of Mentholum, 0.25 gram of methyl salicylate, 0.25 gram of Eupolyphaga Seu Steleophaga, 0.25 gram of Rhizoma Pinelliae, 0.25 gram, Flos Carthami, 0.25 gram of Camphora.
With yellow wine immersion 26 hours; To 46 degrees Celsius of tank body Steam Heating, 13 hours heat time heating times.All the other are with embodiment 1, products obtained therefrom 7.
embodiment 8
1 gram of Rhizoma Zingiberis, 1 gram of Rhizoma Kaempferiae, 1 gram of the Radix Angelicae Dahuricae, 1 gram of Radix Et Rhizoma Nardostachyos, 1 gram of Radix Et Rhizoma Rhei, 1 gram of Radix Saposhnikoviae, 1 gram of Radix Clematidis, 1 gram of Pheretima, 1 gram of Sanguis Draxonis, 1 gram of Rhizoma Coptidis, 0.5 gram of Herba speranskiae tuberculatae, 0.5 gram of Herba Lycopodii, 0.5 gram of Caulis Spatholobi, 0.5 gram of Myrrha, 0.5 gram of Olibanum, 0.5 gram of Borneolum Syntheticum, 9 grams, Semen Persicae, 9 grams of Radix Angelicae Sinensis, 9 grams of Flos Caryophyllis, 9 grams, Fructus Piperis, 9 grams of Cortex Periplocaes, 9 grams of Herba Schizonepetae, 9 grams of Ramulus Cinnamomi, 9 grams of Flos Magnoliaes, 9 grams of Rhizoma Et Radix Notopterygiis, 0.5 gram of Rhizoma Chuanxiong, 0.5 gram of Radix Angelicae Pubescentis, 0.5 gram of Cortex Moutan, 0.5 gram, Fructus Capsici, 0.5 gram of Rhizoma Atractylodis, 0.5 gram of Mentholum, 0.5 gram of methyl salicylate, 0.5 gram of Eupolyphaga Seu Steleophaga, 0.5 gram of Rhizoma Pinelliae, 0.5 gram, Flos Carthami, 1 gram of Camphora.
With yellow wine immersion 27 hours; To 47 degrees Celsius of tank body Steam Heating, 13.5 hours heat time heating times.All the other are with embodiment 1, products obtained therefrom 8.
embodiment 9
0.25 gram of Rhizoma Zingiberis, 0.25 gram of Rhizoma Kaempferiae, 0.25 gram of the Radix Angelicae Dahuricae, 0.25 gram of Radix Et Rhizoma Nardostachyos, 0.25 gram of Radix Et Rhizoma Rhei, 0.25 gram of Radix Saposhnikoviae, 0.25 gram of Radix Clematidis, 0.25 gram of Pheretima, 0.25 gram of Sanguis Draxonis, 0.25 gram of Rhizoma Coptidis, 0.25 gram of Herba speranskiae tuberculatae, 0.25 gram of Herba Lycopodii, 0.25 gram of Caulis Spatholobi, 0.25 gram of Myrrha, 0.25 gram of Olibanum, 0.25 gram of Borneolum Syntheticum, 0.25 gram, Semen Persicae, 0.25 gram of Radix Angelicae Sinensis, 0.25 gram of Flos Caryophylli, 0.25 gram, Fructus Piperis, 0.25 gram of Cortex Periplocae, 0.25 gram of Herba Schizonepetae, 0.25 gram of Ramulus Cinnamomi, 0.25 gram of Flos Magnoliae, 0.25 gram of Rhizoma Et Radix Notopterygii, 9 grams of Rhizoma Chuanxiongs, 9 grams of Radix Angelicae Pubescentiss, 9 grams of Cortex Moutans, 9 grams, Fructus Capsici, 9 grams of Rhizoma Atractylodis, 9 grams of Mentholums, 10 grams of methyl salicylate, 10 grams of Eupolyphaga Seu Steleophagas, 10.5 grams of Rhizoma Pinelliae, 9 grams, Flos Carthami, 6.5 grams of Camphoras.
With yellow wine immersion 28 hours; To 48 degrees Celsius of tank body Steam Heating, 14 hours heat time heating times.All the other are with embodiment 1, products obtained therefrom 9.
embodiment 10
2.6 grams of Rhizoma Zingiberiss, 2.6 grams of Rhizoma Kaempferiaes, 2.6 grams of the Radixs Angelicae Dahuricae, 2.6 grams of Radix Et Rhizoma Nardostachyos, 2.6 grams of Radix Et Rhizoma Rhei, 2.6 grams of Radix Saposhnikoviaes, 2.6 grams of Radix Clematidis, 2.6 grams of Pheretimas, 2.6 grams of Sanguis Draxonis, 2.6 grams of Rhizoma Coptidis, 2.6 grams of Herba speranskiae tuberculataes, 2.6 grams of Herba Lycopodiis, 2.6 grams of Caulis Spatholobis, 2.6 grams of Myrrhas, 2.6 grams of Olibanums, 2.6 grams of Borneolum Syntheticums, 2.6 grams, Semen Persicae, 2.6 grams of Radix Angelicae Sinensis, 2.6 grams of Flos Caryophyllis, 2.6 grams, Fructus Piperis, 2.6 grams of Cortex Periplocaes, 2.6 grams of Herba Schizonepetae, 2.6 grams of Ramulus Cinnamomi, 2.6 grams of Flos Magnoliaes, 2.6 grams of Rhizoma Et Radix Notopterygiis, 2.6 grams of Rhizoma Chuanxiongs, 2.6 grams of Radix Angelicae Pubescentiss, 2.6 grams of Cortex Moutans, 2.6 grams, Fructus Capsici, 2.6 grams of Rhizoma Atractylodis, 2.6 grams of Mentholums, 2.6 grams of methyl salicylate, 2.6 grams of Eupolyphaga Seu Steleophagas, 2.6 grams of Rhizoma Pinelliae, 2.6 grams, Flos Carthami, 9 grams of Camphoras.
With yellow wine immersion 29 hours; To 49 degrees Celsius of tank body Steam Heating, 14.5 hours heat time heating times.All the other are with embodiment 1, products obtained therefrom 10.
embodiment 11
20 grams of Rhizoma Zingiberiss, 10 grams of Rhizoma Kaempferiaes, 10 grams of the Radixs Angelicae Dahuricae, 10 grams of Radix Et Rhizoma Nardostachyos, 10 grams of Radix Et Rhizoma Rhei, 8 grams of Radix Saposhnikoviaes, 8 grams of Radix Clematidis, 8 grams of Pheretimas, 0.5 gram of Sanguis Draxonis, 0.5 gram of Rhizoma Coptidis, 0.5 gram of Herba speranskiae tuberculatae, 0.5 gram of Herba Lycopodii, 0.5 gram of Caulis Spatholobi, 0.5 gram of Myrrha, 0.5 gram of Olibanum, 0.5 gram of Borneolum Syntheticum, 0.5 gram, Semen Persicae, 0.5 gram of Radix Angelicae Sinensis, 0.5 gram of Flos Caryophylli, 0.5 gram, Fructus Piperis, 0.5 gram of Cortex Periplocae, 0.5 gram of Herba Schizonepetae, 0.5 gram of Ramulus Cinnamomi, 0.5 gram of Flos Magnoliae, 0.5 gram of Rhizoma Et Radix Notopterygii, 0.5 gram of Rhizoma Chuanxiong, 0.5 gram of Radix Angelicae Pubescentis, 0.5 gram of Cortex Moutan, 0.5 gram, Fructus Capsici, 0.5 gram of Rhizoma Atractylodis, 0.5 gram of Mentholum, 0.5 gram of methyl salicylate, 0.5 gram of Eupolyphaga Seu Steleophaga, 0.5 gram of Rhizoma Pinelliae, 0.5 gram, Flos Carthami, 2.5 grams of Camphoras.
With yellow wine immersion 30 hours; To 50 degrees Celsius of tank body Steam Heating, 15 hours heat time heating times.All the other are with embodiment 1, products obtained therefrom 11.
embodiment 12
2 grams of Rhizoma Zingiberiss, 1 gram of Rhizoma Kaempferiae, 1 gram of the Radix Angelicae Dahuricae, 0.5 gram of Radix Et Rhizoma Nardostachyos, 0.5 gram of Radix Et Rhizoma Rhei, 0.5 gram of Radix Saposhnikoviae, 0.5 gram of Radix Clematidis, 0.5 gram of Pheretima, 8 grams of Sanguis Draxonis, 8 grams of Rhizoma Coptidis, 8 grams of Herba speranskiae tuberculataes, 8 grams of Herba Lycopodiis, 8 grams of Caulis Spatholobis, 8 grams of Myrrhas, 8 grams of Olibanums, 8 grams of Borneolum Syntheticums, 8 grams, Semen Persicae, 8 grams of Radix Angelicae Sinensis, 0.5 gram of Flos Caryophylli, 0.5 gram, Fructus Piperis, 0.5 gram of Cortex Periplocae, 0.5 gram of Herba Schizonepetae, 0.5 gram of Ramulus Cinnamomi, 0.5 gram of Flos Magnoliae, 0.5 gram of Rhizoma Et Radix Notopterygii, 0.5 gram of Rhizoma Chuanxiong, 0.5 gram of Radix Angelicae Pubescentis, 0.5 gram of Cortex Moutan, 0.5 gram, Fructus Capsici, 0.5 gram of Rhizoma Atractylodis, 0.5 gram of Mentholum, 0.5 gram of methyl salicylate, 0.5 gram of Eupolyphaga Seu Steleophaga, 0.5 gram of Rhizoma Pinelliae, 0.5 gram, Flos Carthami, 5 grams of Camphoras.
With yellow wine immersion 31 hours; To 51 degrees Celsius of tank body Steam Heating, 15.5 hours heat time heating times.All the other are with embodiment 1, products obtained therefrom 12.
embodiment 13
2 grams of Rhizoma Zingiberiss, 1 gram of Rhizoma Kaempferiae, 1 gram of the Radix Angelicae Dahuricae, 0.5 gram of Radix Et Rhizoma Nardostachyos, 0.5 gram of Radix Et Rhizoma Rhei, 0.5 gram of Radix Saposhnikoviae, 0.5 gram of Radix Clematidis, 0.5 gram of Pheretima, 0.5 gram of Sanguis Draxonis, 0.5 gram of Rhizoma Coptidis, 0.5 gram of Herba speranskiae tuberculatae, 0.5 gram of Herba Lycopodii, 0.5 gram of Caulis Spatholobi, 0.5 gram of Myrrha, 0.5 gram of Olibanum, 0.5 gram of Borneolum Syntheticum, 0.5 gram, Semen Persicae, 0.5 gram of Radix Angelicae Sinensis, 8 grams of Flos Caryophyllis, 8 grams, Fructus Piperis, 8 grams of Cortex Periplocaes, 8 grams of Herba Schizonepetae, 8 grams of Ramulus Cinnamomi, 8 grams of Flos Magnoliaes, 8 grams of Rhizoma Et Radix Notopterygiis, 8 grams of Rhizoma Chuanxiongs, 8 grams of Radix Angelicae Pubescentiss, 8 grams of Cortex Moutans, 0.5 gram, Fructus Capsici, 0.5 gram of Rhizoma Atractylodis, 0.5 gram of Mentholum, 0.5 gram of methyl salicylate, 0.5 gram of Eupolyphaga Seu Steleophaga, 0.5 gram of Rhizoma Pinelliae, 0.5 gram, Flos Carthami, 5 grams of Camphoras.
With yellow wine immersion 32 hours; To 52 degrees Celsius of tank body Steam Heating, 16 hours heat time heating times.All the other are with embodiment 1, products obtained therefrom 13.
embodiment 14
2 grams of Rhizoma Zingiberiss, 2 grams of Rhizoma Kaempferiaes, 2 grams of the Radixs Angelicae Dahuricae, 2 grams of Radix Et Rhizoma Nardostachyos, 2 grams of Radix Et Rhizoma Rhei, 2 grams of Radix Saposhnikoviaes, 2 grams of Radix Clematidis, 2 grams of Pheretimas, 2 grams of Sanguis Draxonis, 2 grams of Rhizoma Coptidis, 2 grams of Herba speranskiae tuberculataes, 1 gram of Herba Lycopodii, 0.5 gram of Caulis Spatholobi, 0.5 gram of Myrrha, 0.5 gram of Olibanum, 0.5 gram of Borneolum Syntheticum, 0.5 gram, Semen Persicae, 0.5 gram of Radix Angelicae Sinensis, 0.5 gram of Flos Caryophylli, 0.5 gram, Fructus Piperis, 0.5 gram of Cortex Periplocae, 0.5 gram of Herba Schizonepetae, 0.5 gram of Ramulus Cinnamomi, 0.5 gram of Flos Magnoliae, 0.5 gram of Rhizoma Et Radix Notopterygii, 0.5 gram of Rhizoma Chuanxiong, 0.5 gram of Radix Angelicae Pubescentis, 0.5 gram of Cortex Moutan, 8 grams, Fructus Capsici, 8 grams of Rhizoma Atractylodis, 8 grams of Mentholums, 10 grams of methyl salicylate, 9 grams of Eupolyphaga Seu Steleophagas, 10 grams of Rhizoma Pinelliae, 8 grams, Flos Carthami, 8 grams of Camphoras.
With yellow wine immersion 33 hours; To 53 degrees Celsius of tank body Steam Heating, 16.5 hours heat time heating times.All the other are with embodiment 1, products obtained therefrom 14.
embodiment 15
15 grams of Rhizoma Zingiberiss, 10 grams of Rhizoma Kaempferiaes, 10 grams of the Radixs Angelicae Dahuricae, 8 grams of Radix Et Rhizoma Nardostachyos, 8 grams of Radix Et Rhizoma Rhei, 7 grams of Radix Saposhnikoviaes, 7 grams of Radix Clematidis, 7 grams of Pheretimas, 0.75 gram of Sanguis Draxonis, 0.75 gram of Rhizoma Coptidis, 0.75 gram of Herba speranskiae tuberculatae, 0.75 gram of Herba Lycopodii, 0.75 gram of Caulis Spatholobi, 0.75 gram of Myrrha, 0.75 gram of Olibanum, 0.75 gram of Borneolum Syntheticum, 0.75 gram, Semen Persicae, 0.75 gram of Radix Angelicae Sinensis, 0.75 gram of Flos Caryophylli, 0.75 gram, Fructus Piperis, 0.75 gram of Cortex Periplocae, 0.75 gram of Herba Schizonepetae, 0.75 gram of Ramulus Cinnamomi, 0.75 gram of Flos Magnoliae, 0.75 gram of Rhizoma Et Radix Notopterygii, 0.75 gram of Rhizoma Chuanxiong, 0.75 gram of Radix Angelicae Pubescentis, 0.75 gram of Cortex Moutan, 0.75 gram, Fructus Capsici, 0.75 gram of Rhizoma Atractylodis, 0.75 gram of Mentholum, 1 gram of methyl salicylate, 1 gram of Eupolyphaga Seu Steleophaga, 2.5 grams of Rhizoma Pinelliae, 0.75 gram, Flos Carthami, 5.5 grams of Camphoras.
With yellow wine immersion 34 hours; To 54 degrees Celsius of tank body Steam Heating, 17 hours heat time heating times.All the other are with embodiment 1, products obtained therefrom 15.
embodiment 16
5 grams of Rhizoma Zingiberiss, 2 grams of Rhizoma Kaempferiaes, 2 grams of the Radixs Angelicae Dahuricae, 2 grams of Radix Et Rhizoma Nardostachyos, 2 grams of Radix Et Rhizoma Rhei, 0.75 gram of Radix Saposhnikoviae, 0.75 gram of Radix Clematidis, 0.75 gram of Pheretima, 7 grams of Sanguis Draxonis, 7 grams of Rhizoma Coptidis, 7 grams of Herba speranskiae tuberculataes, 7 grams of Herba Lycopodiis, 7 grams of Caulis Spatholobis, 7 grams of Myrrhas, 7 grams of Olibanums, 7 grams of Borneolum Syntheticums, 7 grams, Semen Persicae, 0.75 gram of Radix Angelicae Sinensis, 0.75 gram of Flos Caryophylli, 0.75 gram, Fructus Piperis, 0.75 gram of Cortex Periplocae, 0.75 gram of Herba Schizonepetae, 0.75 gram of Ramulus Cinnamomi, 0.75 gram of Flos Magnoliae, 0.75 gram of Rhizoma Et Radix Notopterygii, 07.5 gram of Rhizoma Chuanxiong, 0.75 gram of Radix Angelicae Pubescentis, 0.75 gram of Cortex Moutan, 0.75 gram, Fructus Capsici, 0.75 gram of Rhizoma Atractylodis, 0.75 gram of Mentholum, 1 gram of methyl salicylate, 1 gram of Eupolyphaga Seu Steleophaga, 2.5 grams of Rhizoma Pinelliae, 0.75 gram, Flos Carthami, 6 grams of Camphoras.
With yellow wine immersion 35 hours; To 55 degrees Celsius of tank body Steam Heating, 17.5 hours heat time heating times.All the other are with embodiment 1, products obtained therefrom 16.
embodiment 17
5 grams of Rhizoma Zingiberiss, 2 grams of Rhizoma Kaempferiaes, 2 grams of the Radixs Angelicae Dahuricae, 2 grams of Radix Et Rhizoma Nardostachyos, 2 grams of Radix Et Rhizoma Rhei, 0.75 gram of Radix Saposhnikoviae, 0.75 gram of Radix Clematidis, 0.75 gram of Pheretima, 0.75 gram of Sanguis Draxonis, 0.75 gram of Rhizoma Coptidis, 0.75 gram of Herba speranskiae tuberculatae, 0.75 gram of Herba Lycopodii, 0.75 gram of Caulis Spatholobi, 0.75 gram of Myrrha, 0.75 gram of Olibanum, 0.75 gram of Borneolum Syntheticum, 0.75 gram, Semen Persicae, 7 grams of Radix Angelicae Sinensis, 7 grams of Flos Caryophyllis, 7 grams, Fructus Piperis, 7 grams of Cortex Periplocaes, 7 grams of Herba Schizonepetae, 7 grams of Ramulus Cinnamomi, 7 grams of Flos Magnoliaes, 7 grams of Rhizoma Et Radix Notopterygiis, 7 grams of Rhizoma Chuanxiongs, 6 grams of Radix Angelicae Pubescentiss, 0.75 gram of Cortex Moutan, 0.75 gram, Fructus Capsici, 0.75 gram of Rhizoma Atractylodis, 0.75 gram of Mentholum, 1 gram of methyl salicylate, 1 gram of Eupolyphaga Seu Steleophaga, 2.5 grams of Rhizoma Pinelliae, 0.75 gram, Flos Carthami, 0.75 gram of Camphora.
With yellow wine immersion 36 hours; To 56 degrees Celsius of tank body Steam Heating, 18 hours heat time heating times.All the other are with embodiment 1, products obtained therefrom 17.
embodiment 18
5 grams of Rhizoma Zingiberiss, 2 grams of Rhizoma Kaempferiaes, 2 grams of the Radixs Angelicae Dahuricae, 2 grams of Radix Et Rhizoma Nardostachyos, 2 grams of Radix Et Rhizoma Rhei, 0.75 gram of Radix Saposhnikoviae, 0.75 gram of Radix Clematidis, 0.75 gram of Pheretima, 0.75 gram of Sanguis Draxonis, 0.75 gram of Rhizoma Coptidis, 0.75 gram of Herba speranskiae tuberculatae, 0.75 gram of Herba Lycopodii, 0.75 gram of Caulis Spatholobi, 0.75 gram of Myrrha, 0.75 gram of Olibanum, 0.75 gram of Borneolum Syntheticum, 0.75 gram, Semen Persicae, 0.75 gram of Radix Angelicae Sinensis, 0.75 gram of Flos Caryophylli, 0.75 gram, Fructus Piperis, 0.75 gram of Cortex Periplocae, 0.75 gram of Herba Schizonepetae, 0.75 gram of Ramulus Cinnamomi, 0.75 gram of Flos Magnoliae, 0.75 gram of Rhizoma Et Radix Notopterygii, 1 gram of Rhizoma Chuanxiong, 7 grams of Radix Angelicae Pubescentiss, 7 grams of Cortex Moutans, 7 grams, Fructus Capsici, 7 grams of Rhizoma Atractylodis, 7 grams of Mentholums, 7.5 grams of methyl salicylate, 8.5 grams of Eupolyphaga Seu Steleophagas, 7 grams of Rhizoma Pinelliae, 7 grams, Flos Carthami, 6 grams of Camphoras.
With yellow wine immersion 37 hours; To 57 degrees Celsius of tank body Steam Heating, 18.5 hours heat time heating times.All the other are with embodiment 1, products obtained therefrom 18.
embodiment 19
7 grams of Rhizoma Zingiberiss, 2.5 grams of Rhizoma Kaempferiaes, 2.5 grams of the Radixs Angelicae Dahuricae, 2.5 grams of Radix Et Rhizoma Nardostachyos, 2.5 grams of Radix Et Rhizoma Rhei, 2.5 grams of Radix Saposhnikoviaes, 2.5 grams of Radix Clematidis, 2.5 grams of Pheretimas, 2.5 grams of Sanguis Draxonis, 2.5 grams of Rhizoma Coptidis, 2.5 grams of Herba speranskiae tuberculataes, 2.5 grams of Herba Lycopodiis, 2.5 grams of Caulis Spatholobis, 2.5 grams of Myrrhas, 2.5 grams of Olibanums, 2.5 grams of Borneolum Syntheticums, 2.5 grams, Semen Persicae, 2.5 grams of Radix Angelicae Sinensis, 2.5 grams of Flos Caryophyllis, 2.5 grams, Fructus Piperis, 2.5 grams of Cortex Periplocaes, 2.5 grams of Herba Schizonepetae, 2.5 grams of Ramulus Cinnamomi, 2.5 grams of Flos Magnoliaes, 2.5 grams of Rhizoma Et Radix Notopterygiis, 2.5 grams of Rhizoma Chuanxiongs, 2.5 grams of Radix Angelicae Pubescentiss, 2.5 grams of Cortex Moutans, 2.5 grams, Fructus Capsici, 2.5 grams of Rhizoma Atractylodis, 2.5 grams of Mentholums, 2.5 grams of methyl salicylate, 2.5 grams of Eupolyphaga Seu Steleophagas, 3 grams of Rhizoma Pinelliae, 3 grams, Flos Carthami, 7 grams of Camphoras.
With yellow wine immersion 38 hours; To 58 degrees Celsius of tank body Steam Heating, 19 hours heat time heating times.All the other are with embodiment 1, products obtained therefrom 19.
embodiment 20
10 grams of Rhizoma Zingiberiss, 8 grams of Rhizoma Kaempferiaes, 8 grams of the Radixs Angelicae Dahuricae, 6 grams of Radix Et Rhizoma Nardostachyos, 6 grams of Radix Et Rhizoma Rhei, 5 grams of Radix Saposhnikoviaes, 5 grams of Radix Clematidis, 5 grams of Pheretimas, 5 grams of Sanguis Draxonis, 5 grams of Rhizoma Coptidis, 5 grams of Herba speranskiae tuberculataes, 1 gram of Herba Lycopodii, 1 gram of Caulis Spatholobi, 1 gram of Myrrha, 1 gram of Olibanum, 1 gram of Borneolum Syntheticum, 1 gram, Semen Persicae, 1 gram of Radix Angelicae Sinensis, 1 gram of Flos Caryophylli, 1 gram, Fructus Piperis, 1 gram of Cortex Periplocae, 1 gram of Herba Schizonepetae, 1 gram of Ramulus Cinnamomi, 1 gram of Flos Magnoliae, 1 gram of Rhizoma Et Radix Notopterygii, 1 gram of Rhizoma Chuanxiong, 1 gram of Radix Angelicae Pubescentis, 1 gram of Cortex Moutan, 1 gram, Fructus Capsici, 1 gram of Rhizoma Atractylodis, 1 gram of Mentholum, 2 grams of methyl salicylate, 2 grams of Eupolyphaga Seu Steleophagas, 3.5 grams of Rhizoma Pinelliae, 1 gram, Flos Carthami, 3.5 grams of Camphoras.
Yellow wine soaks 39 hours; To 59 degrees Celsius of tank body Steam Heating, 19.5 hours heat time heating times.All the other are with embodiment 1, products obtained therefrom 20.
embodiment 21
7 grams of Rhizoma Zingiberiss, 3 grams of Rhizoma Kaempferiaes, 3 grams of the Radixs Angelicae Dahuricae, 3 grams of Radix Et Rhizoma Nardostachyos, 3 grams of Radix Et Rhizoma Rhei, 1 gram of Radix Saposhnikoviae, 1 gram of Radix Clematidis, 1 gram of Pheretima, 1 gram of Sanguis Draxonis, 1 gram of Rhizoma Coptidis, 1 gram of Herba speranskiae tuberculatae, 5 grams of Herba Lycopodiis, 5 grams of Caulis Spatholobis, 5 grams of Myrrhas, 5 grams of Olibanums, 5 grams of Borneolum Syntheticums, 5 grams, Semen Persicae, 5 grams of Radix Angelicae Sinensis, 5 grams of Flos Caryophyllis, 5 grams, Fructus Piperis, 5 grams of Cortex Periplocaes, 5 grams of Herba Schizonepetae, 1 gram of Ramulus Cinnamomi, 1 gram of Flos Magnoliae, 1 gram of Rhizoma Et Radix Notopterygii, 1 gram of Rhizoma Chuanxiong, 1 gram of Radix Angelicae Pubescentis, 1 gram of Cortex Moutan, 1 gram, Fructus Capsici, 1 gram of Rhizoma Atractylodis, 2.5 grams of Mentholums, 2 grams of methyl salicylate, 2 grams of Eupolyphaga Seu Steleophagas, 3.5 grams of Rhizoma Pinelliae, 1 gram, Flos Carthami, 1 gram of Camphora.
With yellow wine immersion 40 hours; To 60 degrees Celsius of tank body Steam Heating, 20 hours heat time heating times.All the other are with embodiment 1, products obtained therefrom 21.
embodiment 22
7 grams of Rhizoma Zingiberiss, 3 grams of Rhizoma Kaempferiaes, 3 grams of the Radixs Angelicae Dahuricae, 3 grams of Radix Et Rhizoma Nardostachyos, 3 grams of Radix Et Rhizoma Rhei, 1 gram of Radix Saposhnikoviae, 1 gram of Radix Clematidis, 1 gram of Pheretima, 1 gram of Sanguis Draxonis, 1 gram of Rhizoma Coptidis, 1 gram of Herba speranskiae tuberculatae, 1 gram of Herba Lycopodii, 1 gram of Caulis Spatholobi, 1 gram of Myrrha, 1 gram of Olibanum, 1 gram of Borneolum Syntheticum, 1 gram, Semen Persicae, 1 gram of Radix Angelicae Sinensis, 1 gram of Flos Caryophylli, 1 gram, Fructus Piperis, 1 gram of Cortex Periplocae, 1 gram of Herba Schizonepetae, 5 grams of Ramulus Cinnamomi, 5 grams of Flos Magnoliaes, 5 grams of Rhizoma Et Radix Notopterygiis, 5 grams of Rhizoma Chuanxiongs, 5 grams of Radix Angelicae Pubescentiss, 5 grams of Cortex Moutans, 5 grams, Fructus Capsici, 5 grams of Rhizoma Atractylodis, 5 grams of Mentholums, 3 grams of methyl salicylate, 4 grams of Eupolyphaga Seu Steleophagas, 5 grams of Rhizoma Pinelliae, 4 grams, Flos Carthami, 3 grams of Camphoras.
With yellow wine immersion 41 hours; To 60 degrees Celsius of tank body Steam Heating, 20.5 hours heat time heating times.All the other are with embodiment 1, products obtained therefrom 22.
embodiment 23
7 grams of Rhizoma Zingiberiss, 3 grams of Rhizoma Kaempferiaes, 3 grams of the Radixs Angelicae Dahuricae, 3 grams of Radix Et Rhizoma Nardostachyos, 3 grams of Radix Et Rhizoma Rhei, 1 gram of Radix Saposhnikoviae, 1 gram of Radix Clematidis, 1 gram of Pheretima, 1 gram of Sanguis Draxonis, 1 gram of Rhizoma Coptidis, 1 gram of Herba speranskiae tuberculatae, 1 gram of Herba Lycopodii, 1 gram of Caulis Spatholobi, 1 gram of Myrrha, 1 gram of Olibanum, 1 gram of Borneolum Syntheticum, 1 gram, Semen Persicae, 1 gram of Radix Angelicae Sinensis, 1 gram of Flos Caryophylli, 1 gram, Fructus Piperis, 1 gram of Cortex Periplocae, 1 gram of Herba Schizonepetae, 5 grams of Ramulus Cinnamomi, 5 grams of Flos Magnoliaes, 5 grams of Rhizoma Et Radix Notopterygiis, 5 grams of Rhizoma Chuanxiongs, 5 grams of Radix Angelicae Pubescentiss, 5 grams of Cortex Moutans, 5 grams, Fructus Capsici, 5 grams of Rhizoma Atractylodis, 5 grams of Mentholums, 5 grams of methyl salicylate, 7.5 grams of Eupolyphaga Seu Steleophagas, 5 grams of Rhizoma Pinelliae, 5 grams, Flos Carthami, 5 grams of Camphoras.
With yellow wine immersion 42 hours; To 60 degrees Celsius of tank body Steam Heating, 21 hours heat time heating times.All the other are with embodiment 1, products obtained therefrom 23.
embodiment 24
7 grams of Rhizoma Zingiberiss, 3 grams of Rhizoma Kaempferiaes, 3 grams of the Radixs Angelicae Dahuricae, 3 grams of Radix Et Rhizoma Nardostachyos, 3 grams of Radix Et Rhizoma Rhei, 1 gram of Radix Saposhnikoviae, 1 gram of Radix Clematidis, 1 gram of Pheretima, 1 gram of Sanguis Draxonis, 1 gram of Rhizoma Coptidis, 1 gram of Herba speranskiae tuberculatae, 1 gram of Herba Lycopodii, 1 gram of Caulis Spatholobi, 1 gram of Myrrha, 1 gram of Olibanum, 1 gram of Borneolum Syntheticum, 1 gram, Semen Persicae, 1 gram of Radix Angelicae Sinensis, 1 gram of Flos Caryophylli, 1 gram, Fructus Piperis, 1 gram of Cortex Periplocae, 1 gram of Herba Schizonepetae, 4 grams of Ramulus Cinnamomi, 4 grams of Flos Magnoliaes, 4 grams of Rhizoma Et Radix Notopterygiis, 4 grams of Rhizoma Chuanxiongs, 4 grams of Radix Angelicae Pubescentiss, 4 grams of Cortex Moutans, 4 grams, Fructus Capsici, 4 grams of Rhizoma Atractylodis, 4.5 grams of Mentholums, 5 grams of methyl salicylate, 7.5 grams of Eupolyphaga Seu Steleophagas, 5 grams of Rhizoma Pinelliae, 5 grams, Flos Carthami, 5 grams of Camphoras.
With yellow wine immersion 43 hours; To 60 degrees Celsius of tank body Steam Heating, 22 hours heat time heating times.All the other are with embodiment 1, products obtained therefrom 24.
embodiment 25
10 grams of Rhizoma Zingiberiss, 6 grams of Rhizoma Kaempferiaes, 6 grams of the Radixs Angelicae Dahuricae, 6 grams of Radix Et Rhizoma Nardostachyos, 6 grams of Radix Et Rhizoma Rhei, 2 grams of Radix Saposhnikoviaes, 2 grams of Radix Clematidis, 1 gram of Pheretima, 2 grams of Sanguis Draxonis, 2 grams of Rhizoma Coptidis, 3 grams of Herba speranskiae tuberculataes, 3 grams of Herba Lycopodiis, 4 grams of Caulis Spatholobis, 2 grams of Myrrhas, 2 grams of Olibanums, 2 grams of Borneolum Syntheticums, 1 gram, Semen Persicae, 3 grams of Radix Angelicae Sinensis, 3 grams of Flos Caryophyllis, 3 grams, Fructus Piperis, 2 grams of Cortex Periplocaes, 2 grams of Herba Schizonepetae, 2 grams of Ramulus Cinnamomi, 1 gram of Flos Magnoliae, 2 grams of Rhizoma Et Radix Notopterygiis, 1 gram of Rhizoma Chuanxiong, 1 gram of Radix Angelicae Pubescentis, 1 gram of Cortex Moutan, 1 gram, Fructus Capsici, 2 grams of Rhizoma Atractylodis, 3 grams of Mentholums, 3 grams of methyl salicylate, 3 grams of Eupolyphaga Seu Steleophagas, 4 grams of Rhizoma Pinelliae, 3 grams, Flos Carthami, 2 grams of Camphoras.
With yellow wine immersion 45 hours; To 60 degrees Celsius of tank body Steam Heating, 23 hours heat time heating times.All the other are with embodiment 1, products obtained therefrom 25.
embodiment 26
9 grams of Rhizoma Zingiberiss, 4 grams of Rhizoma Kaempferiaes, 4 grams of the Radixs Angelicae Dahuricae, 4 grams of Radix Et Rhizoma Nardostachyos, 4 grams of Radix Et Rhizoma Rhei, 1 gram of Radix Saposhnikoviae, 1 gram of Radix Clematidis, 2 grams of Pheretimas, 1 gram of Sanguis Draxonis, 1 gram of Rhizoma Coptidis, 2 grams of Herba speranskiae tuberculataes, 2 grams of Herba Lycopodiis, 3 grams of Caulis Spatholobis, 1 gram of Myrrha, 1 gram of Olibanum, 3 grams of Borneolum Syntheticums, 2 grams, Semen Persicae, 4 grams of Radix Angelicae Sinensis, 4 grams of Flos Caryophyllis, 4 grams, Fructus Piperis, 3 grams of Cortex Periplocaes, 3 grams of Herba Schizonepetae, 3 grams of Ramulus Cinnamomi, 2 grams of Flos Magnoliaes, 3 grams of Rhizoma Et Radix Notopterygiis, 2 grams of Rhizoma Chuanxiongs, 2 grams of Radix Angelicae Pubescentiss, 2 grams of Cortex Moutans, 2 grams, Fructus Capsici, 1 gram of Rhizoma Atractylodis, 2 grams of Mentholums, 4 grams of methyl salicylate, 4 grams of Eupolyphaga Seu Steleophagas, 5 grams of Rhizoma Pinelliae, 3 grams, Flos Carthami, 2 grams of Camphoras.
With yellow wine immersion 47 hours; Then to 60 degrees Celsius of tank body Steam Heating, 24 hours heat time heating times.All the other are with embodiment 1, products obtained therefrom 26.
embodiment 27
9.756 grams of Rhizoma Zingiberiss, 5.488 grams of Rhizoma Kaempferiaes, 5.488 grams of the Radixs Angelicae Dahuricae, 4.878 grams of Radix Et Rhizoma Nardostachyos, 4.878 grams of Radix Et Rhizoma Rhei, 1.829 grams of Radix Saposhnikoviaes, 1.829 grams of Radix Clematidis, 1.22 grams of Pheretimas, 1.829 grams of Sanguis Draxonis, 1.22 grams of Rhizoma Coptidis, 2.439 grams of Herba speranskiae tuberculataes, 2.439 grams of Herba Lycopodiis, 3.049 grams of Caulis Spatholobis, 1.22 grams of Myrrhas, 1.22 grams of Olibanums, 2.439 grams of Borneolum Syntheticums, 1.22 grams, Semen Persicae, 3.049 grams of Radix Angelicae Sinensis, 3.049 grams of Flos Caryophyllis, 3.049 grams, Fructus Piperis, 2.439 grams of Cortex Periplocaes, 2.439 grams of Herba Schizonepetae, 2.439 grams of Ramulus Cinnamomi, 1.829 grams of Flos Magnoliaes, 2.439 grams of Rhizoma Et Radix Notopterygiis, 1.829 grams of Rhizoma Chuanxiongs, 1.829 grams of Radix Angelicae Pubescentiss, 1.22 grams of Cortex Moutans, 1.22 grams, Fructus Capsici, 1.22 grams of Rhizoma Atractylodis, 2.439 grams of Mentholums, 3.659 grams of methyl salicylate, 3.049 grams of Eupolyphaga Seu Steleophagas, 4.878 grams of Rhizoma Pinelliae, 3.049 grams, Flos Carthami, 2.439 grams of Camphoras.
With yellow wine immersion 48 hours; Then to 60 degrees Celsius of tank body Steam Heating, 24 hours heat time heating times.All the other are with embodiment 1, products obtained therefrom 27.
That the product of gained in embodiment is tested below:
For proving the anti-inflammatory and antalgic effect of invigorating blood circulation of relieving pain and activating blood circulation relaxing muscles and tendons plaster, get respectively healthy Kunming mouse and Wister rat and be divided at random 4 groups, healthy Kunming mouse and Wister rat are provided by Beijing Experimental Animal Center, it is excipient matched group, positive controls and relieving pain and activating blood circulation relaxing muscles and tendons plaster high dose group, relieving pain and activating blood circulation relaxing muscles and tendons plaster low dose group, external vaseline paste respectively, HUOXUE ZHITONG GAO, relieving pain and activating blood circulation relaxing muscles and tendons plaster high dose, relieving pain and activating blood circulation relaxing muscles and tendons plaster low dosage, adopt mice dimethylbenzene auricle edema method, rat paw Ovum Gallus domesticus album swelling method, mice acetic acid twisting method, hot plate method in mice, mouse peritoneal syndrome of blood stasis model sheep red blood cell algoscopy etc. is carried out laboratory observation.Relieving pain and activating blood circulation relaxing muscles and tendons plaster high dose, the per kilogram in embodiment 27 is containing crude drug 100g, i.e. and the product in step (1) shatters into the compositions of the various Chinese medicines before powder.Relieving pain and activating blood circulation relaxing muscles and tendons plaster low dosage, the per kilogram in embodiment 27 is containing crude drug 50g, i.e. and the product in step (1) shatters into the compositions of the various Chinese medicines before powder.Result of the test is in table 2, table 3, table 4, table 5, table 6.
1. antiinflammatory experiment
1.1 pairs of mice dimethylbenzene auricle edema methods cause inflammation 8 Kunming mouses are divided into 4 groups at random, and with vaseline paste, HUOXUE ZHITONG GAO, relieving pain and activating blood circulation relaxing muscles and tendons plaster high dose, low dosage, with supplying reagent, dosage is respectively per kilogram containing 100g, 50g crude drug in whole.Every group of medication in 2 days in advance, each evenly immobilization with adhesive tape, removed medicine after 6 hours.Be coated with dimethylbenzene 0.05ml then to each group of mouse right ear, left ear contrast, put to death laboratory animal after 15 minutes.Draw materials along left auricle same area punching with diameter 6mm card punch, weigh respectively using interaural difference value as swelling index, and obtain suppression ratio.As shown in table 2, relieving pain and activating blood circulation relaxing muscles and tendons plaster high and low dose xylol all has obvious inhibitory action, and this effect is strengthened along with the increase of dosage.
Figure 2014101238939100002DEST_PATH_IMAGE002
Note: swelling=auris dextra weight-left ear weight.
1.2 impacts on the swelling of rat paw Ovum Gallus domesticus album swelling method
Get 8 of healthy Wister rats, random point 4 groups, each rat is all fixing behind back, after 6 minutes, clean local, coating 3 times altogether, after last administration 2 hours, every right back toes subcutaneous injection 10% fresh albumen 0.1ml of each group laboratory animal, measuring each rat respectively at same position thickness in 4 hours with micrometer callipers causes after inflammation, front and back toes difference in diameter is swelling, as shown in table 3, relieving pain and activating blood circulation relaxing muscles and tendons plaster high and low dose all has good inhibitory action to the rat paw inflammation of Ovum Gallus domesticus album induction.
Figure 2014101238939100002DEST_PATH_IMAGE003
Note: toes volume before toes volume after swelling (ml)=cause is scorching-cause is scorching.
2. analgesic experiment
2.1 still use 8 of Kunming mouses to the impact of mice acetic acid twisting method reaction, divide at random 4 groups, and drug of topical application method and time test with antiinflammatory.After cleaning, every lumbar injection 0.6% glacial acetic acid 0.1ml*10g -1, the writhing number of times of each Mus in 15 minutes after record injection analgesic, comparing difference is analyzed.As shown in table 4, relieving pain and activating blood circulation relaxing muscles and tendons plaster high dose and HUOXUE ZHITONG GAO can suppress intensity and the frequency of the mouse writhing that acetic acid causes.
Figure 2014101238939100002DEST_PATH_IMAGE004
8 of the unhealthful kunming mices of 2.2 pairs of hot plate method in mice induced pains, divide 4 groups at random, and drug of topical application method and time test with antiinflammatory.Respectively mice is placed on 56 degrees Celsius of hot plates, records mice with stopwatch and lick the time (second) of metapedes as the pain threshold of this Mus after administration, the threshold of pain improvement value before and after statistics administration.As shown in table 5, relieving pain and activating blood circulation relaxing muscles and tendons plaster has obvious inhibitory action to hot plate method induced pain.
Figure 2014101238939100002DEST_PATH_IMAGE005
Note: the threshold of pain refers to the minimum quantity of stimulus that causes pain.
3. blood circulation promoting and blood stasis dispelling experiment
To 8 of the unhealthful kunming mices of mouse peritoneal syndrome of blood stasis model sheep red blood cell algoscopy, divide at random 4 groups, drug of topical application method and time test with antiinflammatory.After being made to red cell suspension, the anticoagulant Sanguis caprae seu ovis of extraction injects mouse peritoneal, every 0.3ml, and point execution in batches in 8 hours, extracts intraperitoneal liquid and detects residual RBC number, judges absorbing state.As shown in table 6, relieving pain and activating blood circulation relaxing muscles and tendons plaster can obviously promote the absorption of sheep red blood cell in syndrome of blood stasis model body, has good function of promoting blood circulation to disperse blood clots.
 
Note: RBC refers to that erythrocyte claims again erythrocyte or Red blood corpuscle, is a kind of hemocytees maximum in blood.
Result shows: relieving pain and activating blood circulation relaxing muscles and tendons plaster low dosage all has obvious inhibitory action to swelling due to Mice Auricle dimethylbenzene, as table 2.Relieving pain and activating blood circulation relaxing muscles and tendons plaster high and low dose all has good inhibitory action to the rat paw inflammation of Ovum Gallus domesticus album induction, as table 3.The pain that the mouse writhing reaction of relieving pain and activating blood circulation relaxing muscles and tendons plaster high and low dose Dichlorodiphenyl Acetate induction is index has obvious inhibitory action, as table 4.Relieving pain and activating blood circulation relaxing muscles and tendons plaster high and low dose has obvious inhibitory action to hot plate method induced pain, as table 5.Relieving pain and activating blood circulation relaxing muscles and tendons plaster high and low dose can obviously promote the absorption of sheep red blood cell in syndrome of blood stasis model body, has good function of promoting blood circulation to disperse blood clots, as table 6, shows that relieving pain and activating blood circulation relaxing muscles and tendons plaster has good anti-inflammatory and antalgic and function of promoting blood circulation to disperse blood clots.
The patient treatment statistics of the present invention to clinical 32 routine bone matrix hyperplasia, bones and muscles pain and arthralgia, the effective percentage of getting well reaches 93.8%.Be described as follows:
Using method: the product of gained in embodiment is sticked in sufferer skin zone, and every note was with 2 days, and paste each course for the treatment of 8,3 courses for the treatment of.
Observation of curative effect is as table 7:
Figure 2014101238939100002DEST_PATH_IMAGE007
Result shows: wherein have 20 examples to cure, the basic rehabilitation of 10 example, the not effective in cure other drug of using instead of 2 examples is treated, and its effective percentage is 93.8%, cure rate is 62.5%, illustrates that relieving pain and activating blood circulation relaxing muscles and tendons plaster is better to treatment bone matrix hyperplasia, bones and muscles pain and arthralgia therapeutic effect.
By several clinical cases, therapeutic effect of the present invention is described below.
Case 1 Zhao, female, 67 years old, two knee joint pain more than 5 years, when Ambulatory Activity, pain increases the weight of, when stair activity more so.Physical examination: double knee joint is swelling slightly, knee space and kneecap proparea tenderness, double knee joint activity is slightly limited, floating patella test feminine gender; X-ray film shows that femur and tibial bone end occur that lip sample changes, and apex patellae has pointed bony spur, and the sclerosis of subchondral bone matter, is diagnosed as double knee joint degeneration osteoarthritis.Give relieving pain and activating blood circulation relaxing muscles and tendons plaster external application double knee joint, paste every day 2, and after treatment in 1 month, pain obviously alleviates, and joint movement function normal, follows up a case by regular visits to symptom without recurrence after half a year, and X-ray film shows that sclerotin change is without increasing the weight of.
Case 2 poplars, man, 70 years old, within 2009, obtain knee joint hyperosteogeny through hospital diagnosis, with Chinese medicine external application of the present invention affected part, through 2 courses for the treatment of, pain disappears, and through hospital's color ultrasound examination, hypertrophy disappears, patient's recovery from illness.Muscle power is restored gradually.
Case 3 grandsons, man, 65 years old, peasant, obtained lumbar vertebra hyperosteogeny through hospital diagnosis in 2009, and with Chinese medicine external application of the present invention affected part, through 2 courses for the treatment of, pain disappears, and through hospital's color ultrasound examination, hypertrophy area diminishes, and symptom is obviously eased, and patient body takes a turn for the better.
Case 4 Liu, female, 59 years old, within 2010, obtain hyperosteogeny of cervical vertebra through hospital diagnosis, sensation cervical region pain, dizziness, there is nauseating, symptoms of emesis, with Chinese medicine external application of the present invention affected part, through 3 courses for the treatment of, pain disappears, through hospital's color ultrasound examination, cervical region pain, dizziness, there is nauseating, symptoms of emesis substantially to disappear, patient's recovery from illness.
Case 5 Lee, man, 56 years old, within 2010, obtain arthralgia through hospital diagnosis, with Chinese medicine external application of the present invention affected part, through 3 courses for the treatment of, pain disappearance patient recovery from illness.
Case 6 Korea Spro, female, 64 years old, within 2011, obtain bones and muscles pain through hospital diagnosis, with Chinese medicine external application of the present invention affected part, through 3 courses for the treatment of, pain disappears, patient's recovery from illness.
Case 7 Wang, man, 58 years old, within 2011, obtain osteoarthrosis pain through hospital diagnosis, with Chinese medicine external application of the present invention affected part, through 3 courses for the treatment of, pain disappears substantially, and patient fully recovers gradually.
Above the present invention is done to exemplary description; should be noted that; in the situation that not departing from core of the present invention, the replacement that is equal to that any simple distortion, modification or other those skilled in the art can not spend creative work all falls into protection scope of the present invention.

Claims (9)

1. a relieving pain and activating blood circulation relaxing muscles and tendons plaster, it is characterized in that: described relieving pain and activating blood circulation relaxing muscles and tendons plaster comprises according to mass percent: Rhizoma Zingiberis 0.1%-30%, Rhizoma Kaempferiae 0.1%-20%, Radix Angelicae Dahuricae 0.1%-20%, Radix Et Rhizoma Nardostachyos 0.1%-15%, Radix Et Rhizoma Rhei 0.1%-15%, Radix Saposhnikoviae 0.1%-10%, Radix Clematidis 0.1%-10%, Pheretima 0.1%-10%, Sanguis Draxonis 0.1%-10%, Rhizoma Coptidis 0.1%-10%, Herba speranskiae tuberculatae 0.1%-10%, Herba Lycopodii 0.1%-10%, Caulis Spatholobi 0.1%-10%, Myrrha 0.1%-10%, Olibanum 0.1%-10%, Borneolum Syntheticum 0.1%-10%, Semen Persicae 0.1%-10%, Radix Angelicae Sinensis 0.1%-10%, Flos Caryophylli 0.1%-10%, Fructus Piperis 0.1%-10%, Cortex Periplocae 0.1%-10%, Herba Schizonepetae 0.1%-10%, Ramulus Cinnamomi 0.1%-10%, Flos Magnoliae 0.1%-10%, Rhizoma Et Radix Notopterygii 0.1%-10%, Rhizoma Chuanxiong 0.1%-10%, Radix Angelicae Pubescentis 0.1%-10%, Cortex Moutan 0.1%-10%, Fructus Capsici 0.1%-10%, Rhizoma Atractylodis 0.1%-10%, Mentholum 0.1%-10%, methyl salicylate 0.1%-15%, Eupolyphaga Seu Steleophaga 0.1%-10%, Rhizoma Pinelliae 0.1%-15%, Flos Carthami 0.1%-10%, Camphora 0.1%-10%.
2. a kind of relieving pain and activating blood circulation relaxing muscles and tendons plaster according to claim 1, it is characterized in that: described relieving pain and activating blood circulation relaxing muscles and tendons plaster comprises Rhizoma Zingiberis 0.25%-25% according to mass percent, Rhizoma Kaempferiae 0.25%-15%, Radix Angelicae Dahuricae 0.25%-15%, Radix Et Rhizoma Nardostachyos 0.25%-10%, Radix Et Rhizoma Rhei 0.25%-10%, Radix Saposhnikoviae 0.25%-9%, Radix Clematidis 0.25%-9%, Pheretima 0.25%-9%, Sanguis Draxonis 0.25%-9%, Rhizoma Coptidis 0.25%-9%, Herba speranskiae tuberculatae 0.25%-9%, Herba Lycopodii 0.25%-9%, Caulis Spatholobi 0.25%-9%, Myrrha 0.25%-9%, Olibanum 0.25%-9%, Borneolum Syntheticum 0.25%-9%, Semen Persicae 0.25%-9%, Radix Angelicae Sinensis 0.25%-9%, Flos Caryophylli 0.25%-9%, Fructus Piperis 0.25%-9%, Cortex Periplocae 0.25%-9%, Herba Schizonepetae 0.25%-9%, Ramulus Cinnamomi 0.25%-9%, Flos Magnoliae 0.25%-9%, Rhizoma Et Radix Notopterygii 0.25%-9%, Rhizoma Chuanxiong 0.25%-9%, Radix Angelicae Pubescentis 0.25%-9%, Cortex Moutan 0.25%-9%, Fructus Capsici 0.25%-9%, Rhizoma Atractylodis 0.25%-9%, Mentholum 0.25%-9%, methyl salicylate 0.25%-10%, Eupolyphaga Seu Steleophaga 0.25%-10%, Rhizoma Pinelliae 0.25%-10.5%, Flos Carthami 0.25%-9%, Camphora 0.25%-9%.
3. a kind of relieving pain and activating blood circulation relaxing muscles and tendons plaster according to claim 2, it is characterized in that: described relieving pain and activating blood circulation relaxing muscles and tendons plaster comprises according to mass percent: Rhizoma Zingiberis 2%-20%, Rhizoma Kaempferiae 1%-10%, Radix Angelicae Dahuricae 1%-10%, Radix Et Rhizoma Nardostachyos 0.5%-10%, Radix Et Rhizoma Rhei 0.5%-10%, Radix Saposhnikoviae 0.5%-8%, Radix Clematidis 0.5%-8%, Pheretima 0.5%-8%, Sanguis Draxonis 0.5%-8%, Rhizoma Coptidis 0.5%-8%, Herba speranskiae tuberculatae 0.5%-8%, Herba Lycopodii 0.5%-8%, Caulis Spatholobi 0.5%-8%, Myrrha 0.5%-8%, Olibanum 0.5%-8%, Borneolum Syntheticum 0.5%-8%, Semen Persicae 0.5%-8%, Radix Angelicae Sinensis 0.5%-8%, Flos Caryophylli 0.5%-8%, Fructus Piperis 0.5%-8%, Cortex Periplocae 0.5%-8%, Herba Schizonepetae 0.5%-8%, Ramulus Cinnamomi 0.5%-8%, Flos Magnoliae 0.5%-8%, Rhizoma Et Radix Notopterygii 0.5%-8%, Rhizoma Chuanxiong 0.5%-8%, Radix Angelicae Pubescentis 0.5%-8%, Cortex Moutan 0.5%-8%, Fructus Capsici 0.5%-8%, Rhizoma Atractylodis 0.5%-8%, Mentholum 0.5%-8%, methyl salicylate 0.5%-10%, Eupolyphaga Seu Steleophaga 0.5%-9%, Rhizoma Pinelliae 0.5%-10%, Flos Carthami 0.5%-8%, Camphora 0.5%-8%.
4. a kind of relieving pain and activating blood circulation relaxing muscles and tendons plaster according to claim 3, it is characterized in that: described relieving pain and activating blood circulation relaxing muscles and tendons plaster comprises according to mass percent: Rhizoma Zingiberis 5%-15%, Rhizoma Kaempferiae 2%-10%, Radix Angelicae Dahuricae 2%-10%, Radix Et Rhizoma Nardostachyos 2%-8%, Radix Et Rhizoma Rhei 2%-8%, Radix Saposhnikoviae 0.75%-7%, Radix Clematidis 0.75%-7%, Pheretima 0.75%-7%, Sanguis Draxonis 0.75%-7%, Rhizoma Coptidis 0.75%-7%, Herba speranskiae tuberculatae 0.75%-7%, Herba Lycopodii 0.75%-7%, Caulis Spatholobi 0.75%-7%, Myrrha 0.75%-7%, Olibanum 0.75%-7%, Borneolum Syntheticum 0.75%-7%, Semen Persicae 0.75%-7%, Radix Angelicae Sinensis 0.75%-7%, Flos Caryophylli 0.75%-7%, Fructus Piperis 0.75%-7%, Cortex Periplocae 0.75%-7%, Herba Schizonepetae 0.75%-7%, Ramulus Cinnamomi 0.75%-7%, Flos Magnoliae 0.75%-7%, Rhizoma Et Radix Notopterygii 0.75%-7%, Rhizoma Chuanxiong 0.75%-7%, Radix Angelicae Pubescentis 0.75%-7%, Cortex Moutan 0.75%-7%, Fructus Capsici 0.75%-7%, Rhizoma Atractylodis 0.75%-7%, Mentholum 0.75%-7%, methyl salicylate 1%-7.5%, Eupolyphaga Seu Steleophaga 1%-8.5%, Rhizoma Pinelliae 2.5%-7%, Flos Carthami 0.75%-7%, Camphora 0.75%-7%.
5. a kind of relieving pain and activating blood circulation relaxing muscles and tendons plaster according to claim 4, it is characterized in that: described relieving pain and activating blood circulation relaxing muscles and tendons plaster comprises according to mass percent: Rhizoma Zingiberis 7%-10%, Rhizoma Kaempferiae 3%-8%, Radix Angelicae Dahuricae 3%-8%, Radix Et Rhizoma Nardostachyos 3%-6%, Radix Et Rhizoma Rhei 3%-6%, Radix Saposhnikoviae 1%-5%, Radix Clematidis 1%-5%, Pheretima 1%-5%, Sanguis Draxonis 1%-5%, Rhizoma Coptidis 1%-5%, Herba speranskiae tuberculatae 1%-5%, Herba Lycopodii 1%-5%, Caulis Spatholobi 1%-5%, Myrrha 1%-5%, Olibanum 1%-5%, Borneolum Syntheticum 1%-5%, Semen Persicae 1%-5%, Radix Angelicae Sinensis 1%-5%, Flos Caryophylli 1%-5%, Fructus Piperis 1%-5%, Cortex Periplocae 1%-5%, Herba Schizonepetae 1%-5%, Ramulus Cinnamomi 1%-5%, Flos Magnoliae 1%-5%, Rhizoma Et Radix Notopterygii 1%-5%, Rhizoma Chuanxiong 1%-5%, Radix Angelicae Pubescentis 1%-5%, Cortex Moutan 1%-5%, Fructus Capsici 1%-5%, Rhizoma Atractylodis 1%-5%, Mentholum 1%-5%, methyl salicylate 2%-5%, Eupolyphaga Seu Steleophaga 2%-7.5%, Rhizoma Pinelliae 3.5%-5%, Flos Carthami 1%-5%, Camphora 1%-5%.
6. a kind of relieving pain and activating blood circulation relaxing muscles and tendons plaster according to claim 5, it is characterized in that: described relieving pain and activating blood circulation relaxing muscles and tendons plaster comprises according to mass percent: Rhizoma Zingiberis 9%-10%, Rhizoma Kaempferiae 4%-6%, Radix Angelicae Dahuricae 4%-6%, Radix Et Rhizoma Nardostachyos 4%-6%, Radix Et Rhizoma Rhei 4%-6%, Radix Saposhnikoviae 1%-2%, Radix Clematidis 1%-2%, Pheretima 1%-2%, Sanguis Draxonis 1%-2%, Rhizoma Coptidis 1%-2%, Herba speranskiae tuberculatae 2%-3%, Herba Lycopodii 2%-3%, Caulis Spatholobi 3%-4%, Myrrha 1%-2%, Olibanum 1%-2%, Borneolum Syntheticum 2%-3%, Semen Persicae 1%-2%, Radix Angelicae Sinensis 3%-4%, Flos Caryophylli 3%-4%, Fructus Piperis 3%-4%, Cortex Periplocae 2%-3%, Herba Schizonepetae 2%-3%, Ramulus Cinnamomi 2%-3%, Flos Magnoliae 1%-2%, Rhizoma Et Radix Notopterygii 2%-3%, Rhizoma Chuanxiong 1%-2%, Radix Angelicae Pubescentis 1%-2%, Cortex Moutan 1%-2%, Fructus Capsici 1%-2%, Rhizoma Atractylodis 1%-2%, Mentholum 2%-3%, methyl salicylate 3%-4%, Eupolyphaga Seu Steleophaga 3%-4%, Rhizoma Pinelliae 4%-5%, Flos Carthami 3%-4%, Camphora 2%-3%.
7. a kind of relieving pain and activating blood circulation relaxing muscles and tendons plaster according to claim 6, it is characterized in that: described relieving pain and activating blood circulation relaxing muscles and tendons plaster comprises according to mass percent: Rhizoma Zingiberis 9.756%, Rhizoma Kaempferiae 5.488%, the Radix Angelicae Dahuricae 5.488%, Radix Et Rhizoma Nardostachyos 4.878%, Radix Et Rhizoma Rhei 4.878%, Radix Saposhnikoviae 1.829%, Radix Clematidis 1.829%, Pheretima 1.22%, Sanguis Draxonis 1.829%, Rhizoma Coptidis 1.22%, Herba speranskiae tuberculatae 2.439%, Herba Lycopodii 2.439%, Caulis Spatholobi 3.049%, Myrrha 1.22%, Olibanum 1.22%, Borneolum Syntheticum 2.439%, Semen Persicae 1.22%, Radix Angelicae Sinensis 3.049%, Flos Caryophylli 3.049%, Fructus Piperis 3.049%, Cortex Periplocae 2.439%, Herba Schizonepetae 2.439%, Ramulus Cinnamomi 2.439%, Flos Magnoliae 1.829%, Rhizoma Et Radix Notopterygii 2.439%, Rhizoma Chuanxiong 1.829%, Radix Angelicae Pubescentis 1.829%, Cortex Moutan 1.22%, Fructus Capsici 1.22%, Rhizoma Atractylodis 1.22%, Mentholum 2.439%, methyl salicylate 3.659%, Eupolyphaga Seu Steleophaga 3.049%, Rhizoma Pinelliae 4.878%, Flos Carthami 3.049%, Camphora 2.439%.
8. a method of preparing a kind of relieving pain and activating blood circulation relaxing muscles and tendons plaster described in claim 1-7 any one, is characterized in that: comprise the following steps:
Step (1), under aseptic, dustless condition, natural Chinese medicinal herb Rhizoma Zingiberis, Rhizoma Kaempferiae, the Radix Angelicae Dahuricae, Radix Et Rhizoma Nardostachyos, Radix Et Rhizoma Rhei, Radix Saposhnikoviae, Radix Clematidis, Pheretima, Sanguis Draxonis, Rhizoma Coptidis, Herba speranskiae tuberculatae, Herba Lycopodii, Caulis Spatholobi, Myrrha, Olibanum, Borneolum Syntheticum, Semen Persicae, Radix Angelicae Sinensis, Flos Caryophylli, Fructus Piperis, Cortex Periplocae, Herba Schizonepetae, Ramulus Cinnamomi, Flos Magnoliae, Rhizoma Et Radix Notopterygii, Rhizoma Chuanxiong, Radix Angelicae Pubescentis, Cortex Moutan, Fructus Capsici, Rhizoma Atractylodis, Mentholum, Eupolyphaga Seu Steleophaga, Rhizoma Pinelliae, Flos Carthami, Camphora are cleaned;
Step (2), is broken into coarse powder by the Radix Angelicae Dahuricae, Radix Et Rhizoma Nardostachyos, Radix Et Rhizoma Rhei, Radix Saposhnikoviae, Radix Clematidis, Pheretima, Sanguis Draxonis, Rhizoma Coptidis, Herba speranskiae tuberculatae, Herba Lycopodii, Caulis Spatholobi, Myrrha, Olibanum, Semen Persicae, Radix Angelicae Sinensis, Flos Caryophylli, Cortex Periplocae, Herba Schizonepetae, Ramulus Cinnamomi, Flos Magnoliae, Rhizoma Et Radix Notopterygii, Rhizoma Chuanxiong, Radix Angelicae Pubescentis, Cortex Moutan, Fructus Capsici, Rhizoma Atractylodis, Eupolyphaga Seu Steleophaga, Rhizoma Pinelliae, Flos Carthami powder;
Step (3), puts into tank body by the coarse powder of step (2) gained, with yellow wine immersion 20-48 hour; Then to 40-60 degrees Celsius of tank body Steam Heating, heat time heating time 10-24 hour;
Step (4) as solvent, is constantly added solvent with the ethanol of volume ratio 70% in the coarse powder of step (3) gained, makes solvent infiltrate coarse powder, carries out percolation, collects the liquid of filtering, and the liquid of filtering is condensed into relative density and is about 1.03 clear paste;
Step (5), crosses 120 object sieves by Rhizoma Zingiberis, Rhizoma Kaempferiae, Fructus Piperis powder process, then together joins in the clear paste of step (4) gained with methyl salicylate, Mentholum, the Camphora of Borneolum Syntheticum, 98% concentration, stirs; And then the substrate that adds 4～4.5 times of weight to be made by vaseline, zinc oxide, Colophonium, make coating; Then be coated with cream, cutting, lid lining, section, obtain final product.
9. the method for a kind of relieving pain and activating blood circulation relaxing muscles and tendons plaster according to claim 8, is characterized in that: in described step (3), and with yellow wine immersion 48 hours, to 60 degrees Celsius of tank body Steam Heating, 24 hours heat time heating times.
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Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104721040A (en) * 2015-03-24 2015-06-24 蕲春时珍本草科技有限公司 Far infrared moxibustion plaster based on traditional Chinese medicine components
CN105079474A (en) * 2015-09-02 2015-11-25 安徽金马药业有限公司 Musk pain-relieving plaster
CN105106502A (en) * 2015-08-19 2015-12-02 马士远 Medicinal paste for treating hyperostosis and method for preparing medicinal paste
CN105456648A (en) * 2016-01-21 2016-04-06 贵阳中医学院 Compound five-vine pain reliving paster
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CN106266153A (en) * 2016-10-29 2017-01-04 李华 A kind of for Chinese medicine composition dredging collaterals of human and preparation method thereof
CN106310129A (en) * 2016-09-23 2017-01-11 河北地质大学 Traditional Chinese medicine preparation for treating leg pain after sports doing and preparation method thereof
CN106620108A (en) * 2017-02-09 2017-05-10 周志强 Toxin eliminating and pain alleviating ointment
CN107744547A (en) * 2017-10-30 2018-03-02 苏州市嘉信投资咨询有限公司 A kind of compound relieving pain and activating blood circulation dissipates
CN107812151A (en) * 2017-11-02 2018-03-20 胡强南 A kind of eight taste relaxing muscles and tendons external application bags and preparation method thereof
CN109010651A (en) * 2018-09-12 2018-12-18 赖庭荣 A kind of arthralgia emplastrum and preparation method thereof
CN109044920A (en) * 2018-10-18 2018-12-21 广州元汉药业有限公司 A kind of the massage essence and preparation method of the extractive from fermentative of curcuma zedoary containing trigone

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1063819A (en) * 1991-02-05 1992-08-26 王柱亭 A kind of prescription of Kezeng cream
CN1123171A (en) * 1994-11-23 1996-05-29 沈阳市科进工程技术有限公司 Technology for preparation of "Barbe" preparation and product thereof
CN1613463A (en) * 2003-11-07 2005-05-11 北京东方凯恩医药科技有限公司 External applied Chinese medicinal paste for treating arthralgia
CN101485876A (en) * 2009-02-12 2009-07-22 修正药业集团股份有限公司 Preparation method of Chinese medicine emplastrum for expelling rheumatism and relieving pain
CN102698085A (en) * 2012-06-26 2012-10-03 张文秀 Chinese medicinal plaster for treating arthritis

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1063819A (en) * 1991-02-05 1992-08-26 王柱亭 A kind of prescription of Kezeng cream
CN1123171A (en) * 1994-11-23 1996-05-29 沈阳市科进工程技术有限公司 Technology for preparation of "Barbe" preparation and product thereof
CN1613463A (en) * 2003-11-07 2005-05-11 北京东方凯恩医药科技有限公司 External applied Chinese medicinal paste for treating arthralgia
CN101485876A (en) * 2009-02-12 2009-07-22 修正药业集团股份有限公司 Preparation method of Chinese medicine emplastrum for expelling rheumatism and relieving pain
CN102698085A (en) * 2012-06-26 2012-10-03 张文秀 Chinese medicinal plaster for treating arthritis

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
刘化来: "中药巴布剂治疗痹证38例", 《中医外治杂志》 *
张丽芬等: "活血舒筋巴布贴膏剂的基质优选研究", 《中国药业》 *
谢升阳: "活血止痛贴膏的制备", 《中国药物与临床》 *

Cited By (13)

* Cited by examiner, † Cited by third party
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CN104721040A (en) * 2015-03-24 2015-06-24 蕲春时珍本草科技有限公司 Far infrared moxibustion plaster based on traditional Chinese medicine components
CN105106502A (en) * 2015-08-19 2015-12-02 马士远 Medicinal paste for treating hyperostosis and method for preparing medicinal paste
CN105079474A (en) * 2015-09-02 2015-11-25 安徽金马药业有限公司 Musk pain-relieving plaster
CN105456648A (en) * 2016-01-21 2016-04-06 贵阳中医学院 Compound five-vine pain reliving paster
CN105920253A (en) * 2016-06-16 2016-09-07 张庆刚 Wet plaster
CN106310129A (en) * 2016-09-23 2017-01-11 河北地质大学 Traditional Chinese medicine preparation for treating leg pain after sports doing and preparation method thereof
CN106266153A (en) * 2016-10-29 2017-01-04 李华 A kind of for Chinese medicine composition dredging collaterals of human and preparation method thereof
CN106620108A (en) * 2017-02-09 2017-05-10 周志强 Toxin eliminating and pain alleviating ointment
CN107744547A (en) * 2017-10-30 2018-03-02 苏州市嘉信投资咨询有限公司 A kind of compound relieving pain and activating blood circulation dissipates
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