CN105412864A - Pain relieving ointment for treating prolapse of lumbar intervertebral disc - Google Patents
Pain relieving ointment for treating prolapse of lumbar intervertebral disc Download PDFInfo
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- CN105412864A CN105412864A CN201510854823.5A CN201510854823A CN105412864A CN 105412864 A CN105412864 A CN 105412864A CN 201510854823 A CN201510854823 A CN 201510854823A CN 105412864 A CN105412864 A CN 105412864A
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Abstract
A pain relieving ointment for treating prolapse of the lumbar intervertebral disc is prepared from fine medicine and medicine powder. The fine medicine is prepared from, by weight, 120 g of radix clematidis, 60 g of ephedra herb, 90 g of cassia twigs, 90 g of suberect spatholobus stems, 45 g of raw each kernels, 45 g of safflowers, 45 g of radix angelica sinensis, 45 g of rhizoma chuanxiong, 50 g of rhizoma curcumae longae, 50 g of prepared rehmannia roots, 45 g of notopterygium roots, 45 g of radix angelicae pubescentis, 30 g of divaricate saposhnikovia roots, 50 g of pheretima aspergillum, 60 g of garden balsam stems, 30 g of raw rhizoma atractylodis, 45 g of raw fructus aurantii, 50 g of medicinal cyathula roots, 45 g of chaenomeles speciosa, 45 g of dahurian angelica roots, 90 g of herb pyrolae, 60 g of kadsura pepper stems and 120 g of dried ginger. The medicine powder is prepared from 75 g of radix aconiti kusenzoffii and 60 g of radix aconite. The Chinese herbal medicine formulation is adopted, the materials are easy to obtain, a preparation method is simple, the treatment effect is good, the price is low, effect taking is fast, the curative effect is reliable, the pain relieving ointment is prepared when needed, and no obvious adverse reaction or side effect exists.
Description
Technical field
The present invention relates to field of Chinese herbal medicine technology, be specifically related to a kind of ache-reliving plaster being used for the treatment of prolapse of lumbar intervertebral disc.
Background technology
Prolapse of lumbar intervertebral disc is one of comparatively common illness, mainly because lumbar intervertebral disc each several part (vertebral pulp, fibrous ring and cartilaginous lamina), especially vertebral pulp, after having degenerative change in various degree, under the effect of external force factor, the Anular disruption of intervertebral disc, nucleus pulposus is from part outstanding (or deviating from) of breaking in rear or intraspinal tube, adjacent ridge nerve root is caused to be stimulated or oppress, thus generation flank pain, a series of clinical symptoms such as side lower limb or two numbness of lower limbs, pain.Prolapse of lumbar intervertebral disc is the highest with waist 4-5, waist 5-sacrum 1 sickness rate, accounts for 95%.
Summary of the invention
The object of the present invention is to provide a kind of safe and reliable, the ache-reliving plaster of what cure rate was high be used for the treatment of prolapse of lumbar intervertebral disc.
Technical problem to be solved by this invention realizes by the following technical solutions:
Be used for the treatment of an ache-reliving plaster for prolapse of lumbar intervertebral disc, be made up of the crude drug of following weight:
Fines medicine: Radix Clematidis 120g, Herba Ephedrae 60g, Ramulus Cinnamomi 90g, Caulis Spatholobi 90g, raw peach kernel 45g, Flos Carthami 45g, Radix Angelicae Sinensis 45g, Rhizoma Chuanxiong 45g, Rhizoma Curcumae Longae 50g, Radix Rehmanniae Preparata 50g, Rhizoma Et Radix Notopterygii 45g, Radix Angelicae Pubescentis 45g, Radix Saposhnikoviae 30g, LUMBRICUS 50g, Herba speranskiae tuberculatae 60g, atractylodes rhizome 30g, raw Fructus Aurantii 45g, Radix Cyathulae 50g, Fructus Chaenomelis 45g, Radix Angelicae Dahuricae 45g, Herba Pyrolae 90g, Caulis Piperis Kadsurae 60g, Rhizoma Zingiberis 120g;
Medicated powder: Radix Aconiti 75g, Radix Aconiti Kusnezoffii 60g.
Dosage form: plaster (plaster type)
Function: invigorating the liver and kidney, bone and muscle strengthening, blood circulation promoting and blood stasis dispelling, removing obstruction in the collateral to relieve pain.
Cure mainly: the lumbar intervertebral disc caused by the reason such as degenerative change, damage of lumbar intervertebral disc is dashed forward.
Preparation process:
Oil, pellet are made substrate by I plaster processing technology system of institute by a certain percentage, again by thick spice cooking method extraction, simmer down to thick paste or oily with fried extraction making patent medicine, fines and the medicine of the crude drug property of medicine need be kept to be pressed into fine powder, during the cream of stand, thick paste and fine powder are blended in the substrate of heat fused (going most aqueous vapor) with method, after stirring evenly most aqueous vapor, spread out cream." cooking method extraction processing technology " maintains the full composition of medicine, decreases the decomposition loss of medical material active ingredient when refining, reduces costs, easy to make; Resistant to elevated temperatures medicine can use fried method to extract, and following all prescriptions have indicated extracting method all.
One, the preparation of substrate
(1) preparation:
1, instrument: gas stove one, an iron pan 4 (oil refining, red under one, one is filtered use, fry red for one), 60 order ferrum sieve one (filter with), Fireproof cover one (should irony), poking bar one (with fresh Kuwaki, Sophora japonica L., bamboo, should be about 1.2-1.5 meters), pond or large basin one, small laver one.
2, material: (1) oil: have Oleum sesami, cotton seed wet goods, determines by area custom, but is good with Oleum sesami.Oleum sesami itself has the effect of nourishing the lung to arrest cough, and pitch-black glossy, the property of the plaster color and luster boiled is glued; Boil foam in process few, convenient operation.Application has softness, clear and rich, firmly stick together, without uncomfortable advantage without pulling.Owing to keeping the time of lubrication long, and be easily absorbed by the skin, can drug effect be given full play to.
(2) Hydrocerussitum (Ceruse) (official's powder):, matter severe one many with lead tolerance is good.Anhydrate in stir-fry during application and point to sieve.Main component is lead orthoplumbate, is best with red person.Summer 250g/ jin Oleum sesami.Winter 230g/ jin Oleum sesami.(1 jin, a traditional unit of weight of Oleum sesami adds Hydrocerussitum (Ceruse) 200---250 gram in our experience, the number of medicated powder added by main basis, if less at most under Hydrocerussitum (Ceruse) of fines medicine, if some more at least under Hydrocerussitum (Ceruse) of fines medicine), attention: the Oleum sesami of above indication is endure the oil perfected, bucket can be put into claim enduring the oil perfected, then calculate the number of Hydrocerussitum (Ceruse) according to ratio.
Two, refine oil:
Oil refining is the key making plaster substrate, and it is suitable that oil refining degree must be grasped, and this directly has influence on " always ", " tender " of plaster.The normal following standard that is classified as judges:
1, oil smoke: start, for cyan (shallow), to turn black and dense gradually, and then be white dense smoke (more obvious when raising), to see that white dense smoke is as the criterion.
2, oil bloom: when boiling starts, oil bloom are many near pot wall, assemble again after loose and are as the criterion.Should constantly raise during oil refining oil, speed oil of raising when oil will be smelt is wanted soon; Raise oil time all should avoid touching the bottom of a pan, catch fire to prevent fires, during oil refining, fire is unsuitable too quickly, as caught fire, fire pressure is gone out with Fireproof cover.
3, when oil has soon been endured by the time, should do at any time and drip into pearl test, can from Huo Xiadan after Success in Experiment.
4, experience: this process must use moderate heat, temperature slowly raises, directly temper oil generation and approximately need 3.5 hours, if temper medicine oil require 3 hours, the words of tempering oil generation when temperature rises to 320 degree need to adhere to enduring 30 minutes again, the words of tempering medicine oil need to adhere to enduring 20 minutes, and rear lower pellet slightly falls in right turning off stove temperature.
Three, pilling and pasting:
The oil refined is reached 310-320 DEG C red (note: can not lower than 310 DEG C) at present from oil temperatures such as fire, red descended after, the degree that still can heat and temper must be grasped, and check at any time, just can make the old, tender suitable of substrate.Lower pellet scatters even, and ceaselessly stirs along a direction, with the anti-settling poly-the bottom of a pan.The speed excessive pot too soon and easily of lower pellet, and substrate is patchy; Time too slow, not easily grasp again substrate always tender.
Its color to be observed in time after having descended pellet, old, tender inspection should be done immediately when becoming Dark grey or black depending on it, continue heating as partially tender again; Partially always be blended into appropriate tenderer oil refining, general tenderer than better, because still needing heating when doing plaster.
Four, releasing fire-toxin:
Pilling and pasting turning off stove, with in cold water sprays pot, namely has black smoke to emerge, repeated multiple times, in the pond filling more cold water with thread impouring or basin, and stirs clockwise with waddy simultaneously, make it revolve with water and become band when slightly cold.After cooling, twisted into suitably little sticking together, to be dipped in cold water 7-10 days, to change water every day 1-2 times.
Five, cream and prescription is spread out
(1) cream is spread out: the substrate of getting some puts slow fire heating fusing slowly in pot (must slow fire, avoid producing new fire-toxin) go most aqueous vapor (noting observing), right turning off stove, coolly to stir evenly to being blended into thick paste when about 70 DEG C until it, slow fire heating also continuous stirring goes most aqueous vapor, the micro-heated and stirred of slow fire again, cool to adding off-the-shelf fines medicine when about 70 DEG C until it, stir, finally spread out cream.Or by (the operational approach: add water to a pot and boil of pot heat fused in pot, then the pot of dress plaster substrate is put in boiling water pot, get on to the greatest extent to be blended into thick paste after aqueous vapor and to stir evenly until substrate is put into slow fire again after all melting, after going most aqueous vapor again, substrate temperature stirs evenly stand cream to adding fine powder when about 70 degree by the time, such handling safety is reliable, the most applicablely begins to learn student).Used material of mounting is good with cloth matter, and its specification depends on the needs.
(2) prescription:
1, medical material is selected must to meet States Pharmacopoeia specifications and designing requirement.
2, medical material should be processed with method, pulverize, and prepares medicine by designing requirement, and when being blended into medicine before the cream of stand, temperature can not more than 70 DEG C.
3, releasing fire-toxin is wanted thoroughly.
4, black and bright, glossy exquisiteness answered by plaster, and without piebaldism, old tender appropriateness, stand is coated with evenly, and non-trimming breach, can stick together on skin after heating, and not move.
5, plaster plastic bag packaging, medicated powder pulverization, separately fills.Put drying, the storage of shady and cool place or freezen protective.
Pharmaceutical analysis:
Radix Clematidis:
[property of medicine] is pungent, salty, warm.Return urinary bladder channel.
[effect] wind-damp dispelling, the meridian dredging.
[pharmacological action] 1, this product are used for rheumatic arthralgia, and lead to its pungent loose temperature, property is apt to away suddenly, the current twelve regular channels, can wind-damp dispelling, and can stimulate the menstrual flow again stopping numbness pain.No matter all rheumatic arthralgia, apathy, all can use up and down, is the key medicine of rheumatic arthralgia.2, modern medicine finds that Radix Clematidis is containing the material such as Anemonin and Radix Pulsatillae alcohol, saponin, has the effects such as analgesia, diuresis, blood sugar lowering, blood pressure lowering, function of gallbladder promoting, has stronger inhibitory action to fungus etc.
Herba Ephedrae:
[property of medicine] pungent, micro-hardship, temperature.Return lung, urinary bladder channel.
[effect] relieving the exterior syndrome by diaphoresis, depressed lung-energy dispersing, inducing diuresis to remove edema.
The pungent loose hardship of [pharmacological action] Herba Ephedrae is let out, and Wen Tongxuan is smooth, can open the closing of fur, and volatilization has perspiration, and its extract has antiinflammatory action.Its decoct has resisting pathogenic microbes effect.
Ramulus Cinnamomi:
[property of medicine] acrid, sweet, warm.
[effect] diaphoresis expelling pathogenic factors from muscles, warm same passages through which vital energy circulates, supporing yang activating QI.
[pharmacological action] this product is containing volatile oil, and its main component is cinnamic aldehyde, refrigeration function of lowering the temperature again, all inhibited to gold-coloured staphylococci, Staphylococcus albus, Bacillus typhi, common causative dermatophytes, influenza virus.Oleum Cinnamomi, cinnamic aldehyde have inhibitory action to tubercule bacillus, and Oleum Cinnamomi has stomach invigorating, alleviates cramps of gastrointestinal tract and the effect such as diuresis, heart tonifying.Cinnamic aldehyde has analgesia, calmness, anticonvulsant action.
Caulis Spatholobi:
[property of medicine] is bitter, sweet, temperature.Return liver, kidney channel.
[effect] enriches blood, and invigorates blood circulation, dredging collateral.For blood deficiency and yellow complexion, paralysis and numbness, rheumatic arthralgia.
[pharmacological action] water extracting alcohol preparation can increase femoral artery blood flow, reduces vascular resistance, has obvious inhibitory action to platelet aggregation; Water extract and tincture have obvious antiinflammatory action, and have two-way regulating function to immunologic function.
Raw peach kernel:
[property of medicine] bitter, sweet, flat.Slightly poisonous.GUIXIN liver, large intestine channel.
[effect] blood circulation promoting and blood stasis dispelling, loosening bowel to relieve constipation.
[pharmacological action] 1, to demonstrate,prove for multiple congestion, as be retarded by silt in amenorrhea, dysmenorrhea, puerperal stomachache ， mass in the abdomen and traumatic injury etc.And kind stasis of letting out blood system.2, this product is containing amygdaloside, emulsin, allantoinase, Lactose enzyme, vitamin B1, volatile oil, fatty wet goods, there are anticoagulant and more weak haemolysis, effect is improved to blood flow retardance, blood obstacle, blood flow, blood vessel dilating can be increased, and be sedation to maincenter.
Flos Carthami:
[property of medicine] is pungent, warm.GUIXIN, Liver Channel.
[effect] promoting blood circulation to restore menstrual flow, stasis-dispelling and pain-killing.
[pharmacological action] Flos Carthami injection can significantly improve hypoxia-bearing capability, and central nervous system has analgesia, calmness and anticonvulsant action.Safflower extract and the right antiinflammatory action of water extract; Carthamus yellow has immunosuppressive action.
Radix Angelicae Sinensis:
[property of medicine] sweet, acrid, warm.Return liver, the heart, spleen channel.
[effect] tonifying blood and regulating menstruation, promoting blood circulation and stopping pain, loosening bowel to relieve constipation.
[pharmacological action] Radix Angelicae Sinensis has cardioprotection, arrhythmia, atherosclerosis myocardial infarction; suppress smooth muscle; antiplatelet aggregation, antiinflammatory action, enhancing human body immunity function; the protection of cerebral ischemia; antitumor, makes cell proliferation, and the research of the effect such as the liver protecting and kidney modern pharmacology further demonstrates Radix Angelicae Sinensis blood circulation promoting and blood stasis dispelling, the effects such as pain relieving of enriching blood; also find, Radix Angelicae Sinensis has antiinflammatory, scavenging activated oxygen, hepatic cholagogic, protection kidney, strengthens the effects such as immunologic function simultaneously.
Rhizoma Chuanxiong:
[property of medicine] is pungent, temperature.Return liver, gallbladder, pericardium channel.
[effect] blood-activating and qi-promoting, wind-expelling pain-stopping.
The expansible blood vessel of [pharmacological action] Rhizoma Chuanxiong, improves microcirculation; Can surface activity of blood platelet be reduced, suppress platelet aggregation, the formation of pre-preventing thrombosis.There is calm effect, and have obvious and lasting hypotensive effect; The absorption of fracture local hematoma can be accelerated, promote the formation of callus; Various bacteria can be suppressed.
Rhizoma Curcumae Longae:
[property of medicine] is pungent, bitter, temperature.Return liver spleen channel.
[effect] blood-activating and qi-promoting, inducing menstruation to relieve menalgia.
[pharmacological action] 1, the heart, abdomen, breast, hypochondriac pain, amenorrhea, puerperal abdonimal pain and traumatic injury etc. for stagnation of QI and blood, the pungent loose temperature of this product is led to, can blood-activating and qi-promoting, the stasis of blood is fallen apart stagnant logical and pain is separated.2, for rheumatic arthralgia, the pungent temperature of this product and hold concurrently bitter, can outer dispersing wind and cold damp, and interior qi and blood circulation promotion, antalgic, be especially longer than row limb arm and remove arthralgia pain.3, curcumin energy anticoagulant, reduces blood plasma viscosity; There is antiinflammatory action again, have powerful inhibitory action to fungus.
Radix Rehmanniae Preparata:
[property of medicine] is sweet, tepor.Return Liver and kidney warp.
[effect] enriches blood yin nourishing, life essence-filling, marrow-benefitting.
[pharmacological action] 1, impact on medulla hematopoietic system: Radix Rehmanniae Preparata water decoction can promote the recovery of anemia animal erythrocyte, hemoglobin, accelerate propagation, the differentiation of pluripotential hemopoietic stem cell (CFU-S), bone marrow hemopoietic progenitor cell of red blood cell line (CFU-E).2, on the impact of blood coagulation: Radix Rehmanniae Preparata can significantly suppress liver hemorrhagic necrosis stove and simple necrosis.To the hyperlipemia that high lipid food causes, the hepatic vein hemorrhage that fatty liver and rat endotoxin cause, all has the effect of inhibition thrombosis.Thinking activation to plasminogen, is antithrombotic mechanism of action.3, on immune impact: Radix Rehmanniae Preparata alcohol extract, to mouse gavaging, has significant protective effect to the macrophage function suppressed by carrageenin; Antagonist forms cell inhibitory action.4, on the impact of cardiovascular system: wine Radix Rehmanniae Preparata and cook Radix Rehmanniae and have significant hypotensive effect, systolic pressure and diastolic pressure all significantly decline.5, antioxidation.6, the thyroxin state of dysregulation.
Rhizoma Et Radix Notopterygii:
[property of medicine] is pungent, bitter, temperature.Return bladder, kidney channel.
[effect] induces sweat heat radiation, expelling wind and dampness, pain relieving.
[pharmacological action] Rhizoma Et Radix Notopterygii injection has analgesia and refrigeration function, and has inhibitory action to dermatophytes, Brucella.Volatile oil also has antiinflammatory, analgesia, refrigeration function.
Radix Angelicae Pubescentis:
[property of medicine] is pungent, bitter, tepor.Return kidney, urinary bladder channel.
[effect] wind-damp dispelling, pain relieving, induces sweat.
[pharmacological action] Radix Angelicae Pubescentis has antiinflammatory, analgesia and sedation; Inhibitory action is had to platelet aggregation.
Radix Saposhnikoviae:
[property of medicine] is pungent, sweet, tepor.Return bladder, liver, kidney channel.
[effect] expelling pathogenic wind from the body surface, removing dampness to relieve pain, relieving convulsion.
[pharmacological action] this product has antipyretic, antiinflammatory, calmness, analgesia, convulsion, anti-allergic effects.Certain antibacterial action is had to bacillus pyocyaneus and staphylococcus aureus.
LUMBRICUS:
[property of medicine] is salty, cold.Return liver spleen, urinary bladder channel.
[effect] clearing heat for calming endogenous wind, dredging collateral, relievings asthma, diuresis.
[pharmacological action] this product is containing lumbrifebrine, lumbricin, terrestro-lumbrolysin, again containing nitrogen substance and xanthine, adenine, guanine, choline etc., have good refrigeration function, have calm anticonvulsant action, Pheretima can also strengthen the effects such as immunity, antitumor, antibacterial, diuresis.
Herba speranskiae tuberculatae:
[property of medicine] is pungent, temperature.Return lung Liver Channel.
[effect] expelling wind and removing dampness; Relaxing muscles and tendons to promote blood circulation; Dissipating blood stasis for subsidence of swelling; Removing toxic substances ophthalmalgia.Main air pain of dampness syndrome; Muscles and bones contracture.
[pharmacological action] is for diseases such as rheumatic ostalgia, traumatic injury, menstruation apolipsis, carbuncle furunculosis, the tuberculosis of cervical lymph nodes.
Atractylodes rhizome:
[property of medicine] is pungent, bitter, temperature.Return taste Liver Channel.
[effect] is drying damp and strengthening spleen, expelling wind and cold.
[pharmacological action] low dose is sedation, makes spinal reflex hyperfunction simultaneously; Heavy dose is then in inhibitory action.
Raw Fructus Aurantii:
[property of medicine] is bitter, pungent, sour, warm.Return taste large intestine channel.
[effect] dispelling the stagnated QI removing food stagnancy, reduces phlegm except painful abdominal mass.
[pharmacological action] this product can increase blood flow, and effect comparatively relaxes, and is longer than circulation of qi promoting and opens breast, alleviating distention in middle-JIAO de-swelling.
Radix Cyathulae:
[property of medicine] is bitter, sweet, sour, flat.Return Liver and kidney warp.
[effect] promoting blood circulation to restore menstrual flow, invigorating the liver and kidney, bone and muscle strengthening, moisturizing is treating stranguria, ignites descending.
[pharmacological action] Radix Achyranthis Bidentatae can reduce whole blood viscosity, hematocrit, erythrocyte aggregation index, and has anticoagulation, in addition, also has antiinflammatory, analgesic activity, improves immunity of organisms.
Fructus Chaenomelis:
[property of medicine] acid, temperature.Return liver spleen channel.
[effect] relaxing muscles and tendons and activating QI and blood in the collateral, and brown stomach removing dampness.
[pharmacological action] fresh Sucus Chaenomelis and Fructus Chaenomelis decoct juice has obvious bacteriostasis to intestinal and staphylococcus.
The Radix Angelicae Dahuricae:
[property of medicine] is pungent, warm.Return lung stomach large intestine channel.
[effect] induces sweat heat radiation, wind-expelling pain-stopping, clearing the nasal passage, dampness leukorrhagia stopping, detumescence and apocenosis.
[pharmacological action] Radix Angelicae Dahuricae has antipyretic, antiinflammatory, analgesia, spasmolytic, antitumaous effect, has certain inhibitory action to fungus.
Herba Pyrolae:
[property of medicine] is sweet, bitter, temperature.Return Liver and kidney warp.
[effect] wind-damp dispelling, bone and muscle strengthening, hemostasis, cough-relieving.
[pharmacological action] this product has antiinflammatory, hypotensive effect; Heart and brain spleen kidney and extremity can be expanded, increase blood flow, strengthen immunologic function, have inhibitory action to various bacteria.
Caulis Piperis Kadsurae:
[property of medicine] is pungent, bitter, tepor.Return Liver Channel.
[effect] wind-damp dispelling, removing obstruction in the collateral to relieve pain.
[pharmacological action] Caulis Piperis Kadsurae energy induced by endotoxin is suffered a shock; Can antagonism thrombosis, extend clotting time.
Rhizoma Zingiberis:
[property of medicine] is pungent, heat.Return taste kidney cardiopulmonary warp.
[effect] warming spleen and stomach for dispelling cold, recuperating depleted YANG is promoted blood circulation, warming the lung to resolve fluid-retention.
[pharmacological action] Rhizoma Zingiberis extract has the effect of calmness, analgesia, antiinflammatory, preventing or arresting vomiting.
Medicated powder
Radix Aconiti:
[property of medicine] is pungent, bitter, heat.Very toxic.GUIXIN Liver and kidney spleen channel.
[effect] wind-damp dispelling, antalgic.
[pharmacological action] 1, antiinflammatory action: the foot swelling that aconitines can significantly suppress rat carrageenan, fresh egg soup, histamine and 5-hydroxy tryptamine to cause.2, expand blood vessel, hypotensive effect: all expansible blood vessel of Radix Aconiti and aconitine, play transient hypotensive effect.3, Radix Aconiti has analgesia, local anesthetic action: aconitine system alkaloid is its effective ingredient, and above-mentioned effect is all centrals.4, cardiotonic and toxicity: Radix Aconiti water decoction has cardiotonic to isolated frog heart.But Radix Aconiti has very strong toxicity, aconitine is excessive when causing poisoning, and first make heartbeat strengthen, then cause conduction block and arrhythmia, last heart stops at relaxing period.Aconitine cause the performance position respiratory stimulant of Homoiotherm acute poisoning, sialorrhea, paralysis motorica, latter stage spasm, vomiting sample harness motion, be called aconitine symptom.
Radix Aconiti Kusnezoffii:
[property of medicine] is pungent, bitter, heat.Very toxic.GUIXIN Liver and kidney spleen channel.
[effect] wind-damp dispelling, antalgic.
[pharmacological action] 1. Radix Aconiti Kusnezoffii crude drug preparation, aconitine, hypaconitine, to the pain reaction caused by electricity irritation Mus tail method or hot plate method, all has analgesic activity, and Aconitum carmichjaelii Debx. total alkaloids is to the rabbit ear swelling caused because of heat, and mouse experiment peritonitis all has antiinflammatory action.Clinically Radix Aconiti Kusnezoffii is made every 2ml containing the injection of total alkaloids 2mg, intramuscular injection or with Radix Aconiti Kusnezoffii Preparata and other medicines compatibility, treat rheumatic arthritis, lumbago and skelalgia, neuralgia etc.2. aconitine produces stimulation to Mucocutaneous sensory nerve ending, have itch, hotness, then to suppress and in local anesthesia effect.Tincture is made for topical anesthesia clinically with Radix Aconiti Kusnezoffii and his medicine; Or crude drug is fitted over external in plaster, there is narcotic analgesic effect.
Use:
Get and prepare one, plaster, the medicated powder of pulverization is evenly sprinkling upon plaster surface, with heater homogeneous heating to 50 degree left and right, local plaster deliquescing, medicated powder is melted in plaster, (touching non-scald on hand for degree with hands), plaster is applied ointment or plaster in patient affected part, immobilization with adhesive tape, indwelling 6 days.
Efficacy analysis:
This medicine, clinical practice 16 years, cures patient more than 2000 example, and carries out long-term tracking and pay a return visit, and finds the mechanotherapies such as patient compliance's pin cutter, and adhesive plaster 3-5 course for the treatment of, adjuvant drug, functional exercise, and symptom is obviously alleviated, evident in efficacy.
Complementary therapy: 1, needle-knife solution decompression treatment, three-dimensional computer reduced operation;
2, Western medicine auxiliary treatment: 1. non-steroidal drug, as: ibuprofen, Ying Taiqing; 2. activating blood and removing stasis drug, as: neck waist health, HUOXUE ZHIRONG JIAONANG;
3, suitably functional exercise;
4, avoid bearing a heavy burden, avoiding tobacco and wine;
In order to verify clinical efficacy, this prescription is tried out at Jieshou City apoplexy sequela institute, and by random selecting wherein 200 routine patients, the course for the treatment of the shortest 1 course for the treatment of (6 days), the longest is the 3-5 course for the treatment of.
According to instructions of taking of the present invention.
Efficacy determination: adopt grade III Standard;
1. cure: clinical symptoms disappears substantially.
2. take a turn for the better: clinical symptoms obviously alleviates.
3. invalid: clinical symptoms is not improved.
Concrete clinical treatment outcome is see table 1.
Table 1
| Number of cases | Recovery from illness | Effectively | Invalid | Effective percentage (%) |
| 200 | 160 | 40 | 0 | 100 |
Medical treatment result: effective percentage 100%, sums up we's treatment prolapse of lumbar intervertebral disc, determined curative effect, and can change pathological symptom.
The invention has the beneficial effects as follows: the present invention adopts Chinese herbal medicine formula, material is easy to get, and preparation method is simple, and therapeutic effect is good, and price is low, instant effect, and curative effect is reliable, with system with without obvious adverse reaction and side effect.
Detailed description of the invention
The technological means realized to make the present invention, creation characteristic, reaching object and effect is easy to understand, below in conjunction with specific embodiment, setting forth the present invention further.
Embodiment 1
Be used for the treatment of an ache-reliving plaster for prolapse of lumbar intervertebral disc, be made up of the crude drug of following weight:
Fines medicine: Radix Clematidis 120g, Herba Ephedrae 60g, Ramulus Cinnamomi 90g, Caulis Spatholobi 90g, raw peach kernel 45g, Flos Carthami 45g, Radix Angelicae Sinensis 45g, Rhizoma Chuanxiong 45g, Rhizoma Curcumae Longae 50g, Radix Rehmanniae Preparata 50g, Rhizoma Et Radix Notopterygii 45g, Radix Angelicae Pubescentis 45g, Radix Saposhnikoviae 30g, LUMBRICUS 50g, Herba speranskiae tuberculatae 60g, atractylodes rhizome 30g, raw Fructus Aurantii 45g, Radix Cyathulae 50g, Fructus Chaenomelis 45g, Radix Angelicae Dahuricae 45g, Herba Pyrolae 90g, Caulis Piperis Kadsurae 60g, Rhizoma Zingiberis 120g;
Medicated powder: Radix Aconiti 75g, Radix Aconiti Kusnezoffii 60g.
Dosage form: plaster (plaster type)
Function: invigorating the liver and kidney, bone and muscle strengthening, blood circulation promoting and blood stasis dispelling, removing obstruction in the collateral to relieve pain.
Cure mainly: the lumbar intervertebral disc caused by the reason such as degenerative change, damage of lumbar intervertebral disc is dashed forward.
Preparation process:
Oil, pellet are made substrate by I plaster processing technology system of institute by a certain percentage, again by thick spice cooking method extraction, simmer down to thick paste or oily with fried extraction making patent medicine, fines and the medicine of the crude drug property of medicine need be kept to be pressed into fine powder, during the cream of stand, thick paste and fine powder are blended in the substrate of heat fused (going most aqueous vapor) with method, after stirring evenly most aqueous vapor, spread out cream." cooking method extraction processing technology " maintains the full composition of medicine, decreases the decomposition loss of medical material active ingredient when refining, reduces costs, easy to make; Resistant to elevated temperatures medicine can use fried method to extract, and following all prescriptions have indicated extracting method all.
One, the preparation of substrate
(1) preparation:
1, instrument: gas stove one, an iron pan 4 (oil refining, red under one, one is filtered use, fry red for one), 60 order ferrum sieve one (filter with), Fireproof cover one (should irony), poking bar one (with fresh Kuwaki, Sophora japonica L., bamboo, should be about 1.2-1.5 meters), pond or large basin one, small laver one.
2, material: (1) oil: have Oleum sesami, cotton seed wet goods, determines by area custom, but is good with Oleum sesami.Oleum sesami itself has the effect of nourishing the lung to arrest cough, and pitch-black glossy, the property of the plaster color and luster boiled is glued; Boil foam in process few, convenient operation.Application has softness, clear and rich, firmly stick together, without uncomfortable advantage without pulling.Owing to keeping the time of lubrication long, and be easily absorbed by the skin, can drug effect be given full play to.
(2) Hydrocerussitum (Ceruse) (official's powder):, matter severe one many with lead tolerance is good.Anhydrate in stir-fry during application and point to sieve.Main component is lead orthoplumbate, is best with red person.Summer 250g/ jin Oleum sesami.Winter 230g/ jin Oleum sesami.(1 jin, a traditional unit of weight of Oleum sesami adds Hydrocerussitum (Ceruse) 200---250 gram in our experience, the number of medicated powder added by main basis, if less at most under Hydrocerussitum (Ceruse) of fines medicine, if some more at least under Hydrocerussitum (Ceruse) of fines medicine), attention: the Oleum sesami of above indication is endure the oil perfected, bucket can be put into claim enduring the oil perfected, then calculate the number of Hydrocerussitum (Ceruse) according to ratio.
Two, refine oil:
Oil refining is the key making plaster substrate, and it is suitable that oil refining degree must be grasped, and this directly has influence on " always ", " tender " of plaster.The normal following standard that is classified as judges:
1, oil smoke: start, for cyan (shallow), to turn black and dense gradually, and then be white dense smoke (more obvious when raising), to see that white dense smoke is as the criterion.
2, oil bloom: when boiling starts, oil bloom are many near pot wall, assemble again after loose and are as the criterion.Should constantly raise during oil refining oil, speed oil of raising when oil will be smelt is wanted soon; Raise oil time all should avoid touching the bottom of a pan, catch fire to prevent fires, during oil refining, fire is unsuitable too quickly, as caught fire, fire pressure is gone out with Fireproof cover.
3, when oil has soon been endured by the time, should do at any time and drip into pearl test, can from Huo Xiadan after Success in Experiment.
4, experience: this process must use moderate heat, temperature slowly raises, directly temper oil generation and approximately need 3.5 hours, if temper medicine oil require 3 hours, the words of tempering oil generation when temperature rises to 320 degree need to adhere to enduring 30 minutes again, the words of tempering medicine oil need to adhere to enduring 20 minutes, and rear lower pellet slightly falls in right turning off stove temperature.
Three, pilling and pasting:
The oil refined is reached 310-320 DEG C red (note: can not lower than 310 DEG C) at present from oil temperatures such as fire, red descended after, the degree that still can heat and temper must be grasped, and check at any time, just can make the old, tender suitable of substrate.Lower pellet scatters even, and ceaselessly stirs along a direction, with the anti-settling poly-the bottom of a pan.The speed excessive pot too soon and easily of lower pellet, and substrate is patchy; Time too slow, not easily grasp again substrate always tender.
Its color to be observed in time after having descended pellet, old, tender inspection should be done immediately when becoming Dark grey or black depending on it, continue heating as partially tender again; Partially always be blended into appropriate tenderer oil refining, general tenderer than better, because still needing heating when doing plaster.
Four, releasing fire-toxin:
Pilling and pasting turning off stove, with in cold water sprays pot, namely has black smoke to emerge, repeated multiple times, in the pond filling more cold water with thread impouring or basin, and stirs clockwise with waddy simultaneously, make it revolve with water and become band when slightly cold.After cooling, twisted into suitably little sticking together, to be dipped in cold water 7-10 days, to change water every day 1-2 times.
Five, cream and prescription is spread out
(1) cream is spread out: the substrate of getting some puts slow fire heating fusing slowly in pot (must slow fire, avoid producing new fire-toxin) go most aqueous vapor (noting observing), right turning off stove, coolly to stir evenly to being blended into thick paste when about 70 DEG C until it, slow fire heating also continuous stirring goes most aqueous vapor, the micro-heated and stirred of slow fire again, cool to adding off-the-shelf fines medicine when about 70 DEG C until it, stir, finally spread out cream.Or by (the operational approach: add water to a pot and boil of pot heat fused in pot, then the pot of dress plaster substrate is put in boiling water pot, get on to the greatest extent to be blended into thick paste after aqueous vapor and to stir evenly until substrate is put into slow fire again after all melting, after going most aqueous vapor again, substrate temperature stirs evenly stand cream to adding fine powder when about 70 degree by the time, such handling safety is reliable, the most applicablely begins to learn student).Used material of mounting is good with cloth matter, and its specification depends on the needs.
(2) prescription:
1, medical material is selected must to meet States Pharmacopoeia specifications and designing requirement.
2, medical material should be processed with method, pulverize, and prepares medicine by designing requirement, and when being blended into medicine before the cream of stand, temperature can not more than 70 DEG C.
3, releasing fire-toxin is wanted thoroughly.
4, black and bright, glossy exquisiteness answered by plaster, and without piebaldism, old tender appropriateness, stand is coated with evenly, and non-trimming breach, can stick together on skin after heating, and not move.
5, plaster plastic bag packaging, medicated powder pulverization, separately fills.Put drying, the storage of shady and cool place or freezen protective.
Use:
Get and prepare one, plaster, the medicated powder of pulverization is evenly sprinkling upon plaster surface, with heater homogeneous heating to 50 degree left and right, local plaster deliquescing, medicated powder is melted in plaster, (touching non-scald on hand for degree with hands), plaster is applied ointment or plaster in patient affected part, immobilization with adhesive tape, indwelling 6 days.
Model case
King so-and-so, man, 72 years old, because " flank pain more than 10 years, increases the weight of 1 week." carry out my Out-patient Department and seek medical advice; look into: waist is anteflexion, after stretch and lateroflexion movable part limited, waist vertebra other tenderness, percussion pain (+), without obvious two lower limb radiating pain; bilateral buttocks gluteus medius, piriformis district being dispersed in property tenderness, local skin has no obvious redness, heating.Bilateral straight-leg raising test (+), strengthens test (+), hip in the wrong of going down on one's knees test (+), muscular strength Pyatyi, and muscular tension is normal, and nervous system shows no obvious abnormalities.Auxiliary inspection: lumbar vertebra CT shows: 1, slippage before L5 vertebral body; 2, outstanding after L5-S1 intervertebral disc.Patient diagnosis is " prolapse of lumbar intervertebral disc ".Give the external application of strong waist ache-reliving plaster, and advise it to go home to take a good rest, suitable functional exercise.Follow up a case by regular visits to patient's waist pain after 20 days substantially to disappear, my institute required to continue to stick 2 courses for the treatment of with consolidate curative effect afterwards.Follow up a case by regular visits to patient's lumbago symptom after 1 year not recur again.
Zhang, man, 69 years old, " the two buttocks of lumbago companion was ached 5 years, increases the weight of first quarter moon." before first quarter moon more than the massage physical therapy of local clinic, transfusion, oral drugs first quarter moon; private prosecution symptom has no improvement; affect patient's orthobiosis and work; I seeks medical advice at institute then; have a medical check-up when coming: waist is anteflexion, after to stretch and lateroflexion activity all has obviously limited, waist vertebra other tenderness, percussion pain (++), and the two buttocks radioactivity acid of companion is sunk; bilateral buttocks gluteus medius, piriformis district popularity tenderness, local skin has no obvious redness, heating.Bilateral straight-leg raising test (++), strengthens test (++), hip in the wrong of going down on one's knees test (++), muscular strength 4 grades, and muscular tension reduces, and nervous system shows no obvious abnormalities.Auxiliary inspection: waist CT shows: L3-S1 intervertebral disk hernia sexually revises.Then give the treatment of row waist needle-knife solution art, art finishes the strong waist ache-reliving plaster of external application, process of lying up; Patient's waist pain relief after 6 days course for the treatment of, bilateral buttocks still has acid heavy, after giving the two buttocks needle-knife solution art treatment of row, gives waist and the strong waist ache-reliving plaster of two buttocks external application; After two courses for the treatment of, reviewing patient's waist and two pain of buttock all disappear again, waist and two lower limb exercise degree normal, continue and give 2 courses for the treatment of of strong waist ache-reliving plaster external application.Pay a return visit after 1 year, the above symptom of patient is not all in recurrence.
Zhang, female, 65 years old, because of " lumbago more than 10 years, the two lower limb ache of companion more than 2 years." be admitted to hospital.Come time have a medical check-up: each mobility of waist is all limited, waist tenderness, percussion pain (+), two lower limb ache, numbness, bilateral buttocks and two numbness of lower limbs more very, especially with after activity more very; Bilateral straight-leg raising test (+), strengthens test (+), " 4 " word test (-), hip in the wrong of going down on one's knees test (-), and muscular strength is normal, and physiological reflex exists, and pathologic reflex is not drawn.Auxiliary inspection: lumbar vertebra CT sheet shows: L3-S1 intervertebral disk hernia.Be diagnosed as " prolapse of lumbar intervertebral disc ".While in hospital gives waist needle-knife solution art, postoperatively gives the external application of strong waist ache-reliving plaster, and coordinates the drug oral such as Ying Taiqing, neck waist health, and after 6 days, patient's waist mobility is clearly better, and pain symptom disappears, and handles and leaves hospital.Continue and give 3 courses for the treatment of of strong waist ache-reliving plaster external application, follow up a case by regular visits to patient's waist and two lower limb pain transference cure after January, mobility is as usual.Follow up a case by regular visits to patients symptomatic after half a year not recur again.
More than show and describe ultimate principle of the present invention and principal character and advantage of the present invention.The technical staff of the industry should understand; the present invention is not restricted to the described embodiments; what describe in above-described embodiment and description just illustrates principle of the present invention; without departing from the spirit and scope of the present invention; the present invention also has various changes and modifications, and these changes and improvements all fall in the claimed scope of the invention.Application claims protection domain is defined by appending claims and equivalent thereof.
Claims (1)
1. be used for the treatment of an ache-reliving plaster for prolapse of lumbar intervertebral disc, it is characterized in that, be made up of the crude drug of following weight:
Fines medicine: Radix Clematidis 120g, Herba Ephedrae 60g, Ramulus Cinnamomi 90g, Caulis Spatholobi 90g, raw peach kernel 45g, Flos Carthami 45g, Radix Angelicae Sinensis 45g, Rhizoma Chuanxiong 45g, Rhizoma Curcumae Longae 50g, Radix Rehmanniae Preparata 50g, Rhizoma Et Radix Notopterygii 45g, Radix Angelicae Pubescentis 45g, Radix Saposhnikoviae 30g, LUMBRICUS 50g, Herba speranskiae tuberculatae 60g, atractylodes rhizome 30g, raw Fructus Aurantii 45g, Radix Cyathulae 50g, Fructus Chaenomelis 45g, Radix Angelicae Dahuricae 45g, Herba Pyrolae 90g, Caulis Piperis Kadsurae 60g, Rhizoma Zingiberis 120g;
Medicated powder: Radix Aconiti 75g, Radix Aconiti Kusnezoffii 60g.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510854823.5A CN105412864A (en) | 2015-11-26 | 2015-11-26 | Pain relieving ointment for treating prolapse of lumbar intervertebral disc |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510854823.5A CN105412864A (en) | 2015-11-26 | 2015-11-26 | Pain relieving ointment for treating prolapse of lumbar intervertebral disc |
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| CN105412864A true CN105412864A (en) | 2016-03-23 |
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| CN113041329A (en) * | 2021-05-11 | 2021-06-29 | 陈锦辉 | Traditional Chinese medicine composition and plaster for treating lumbar disc herniation and arthralgia |
| CN114452361A (en) * | 2022-03-12 | 2022-05-10 | 陈志贵 | External application plaster for treating neck, shoulder, waist and leg pain and preparation method thereof |
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| CN101040930A (en) * | 2007-04-19 | 2007-09-26 | 乔兴茂 | Chinese traditional medicine for treating protrusion of lumbar intervertebral disc for external application |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN113041329A (en) * | 2021-05-11 | 2021-06-29 | 陈锦辉 | Traditional Chinese medicine composition and plaster for treating lumbar disc herniation and arthralgia |
| CN114452361A (en) * | 2022-03-12 | 2022-05-10 | 陈志贵 | External application plaster for treating neck, shoulder, waist and leg pain and preparation method thereof |
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Application publication date: 20160323 |