CN104940390A - Traditional Chinese medicine preparation for treating knee arthroncus and preparation method thereof - Google Patents
Traditional Chinese medicine preparation for treating knee arthroncus and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine preparation for treating knee arthroncus. The traditional Chinese medicine preparation comprises, by weight, 10-16 parts of cortex acanthopanacis, 3-6 parts of placuna placenta shells, 8-12 parts of ardisia crenata, 10-15 parts of aralia cordata, 9-13 parts of golden cypress, 12-17 parts of caulis sinomenii, 10-14 parts of torenia fournieril, 6-12 parts of pine nodular branches, 8-13 parts of theezan tea, 10-17 parts of mazus stachydifolius, 9-15 parts of mulberry twigs, 7-14 parts of polyporus umbellatus and 11-16 parts of shrubby breynia. The traditional Chinese medicine preparation has the good effects of relieving swelling and pain and enhancing the effects of dispelling wind and removing damp and promoting blood circulation to remove meridian obstruction. The selected materials are traditional Chinese medicine, and have no toxic or side effects. The traditional Chinese medicine preparation is developed by combining traditional Chinese medicine differentiation treatment and modern latest science research progress, the traditional Chinese medicine materials are combined, and the traditional Chinese medicine preparation has the advantages of being obvious in treatment effect, safe, convenient to prepare, and low in cost.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to a kind of Chinese medicine for the treatment of the arthroncus of knee and preparation method thereof.
Background technology
The arthroncus of knee, modern medicine becomes synovial bursae of knee joint scorching, also becomes kneecap inferior synovial membrane capsulitis.Motherland's medical science claims " arthroncus of knee ", " arthroncus of the knee " etc., belongs to arthromyodynia category.Be wait exopathogen to invade human body impatency meridians because wind and cold is damp and hot, not smooth the caused muscle muscles and bones of QI-blood circulation, joint ached, numbness weighs, joint stuffiness, even or arthroncus scorching hot etc. be the disease of main clinical manifestation.Modern medicine is thought to be hit by wound, fall, sprain, hyperkinesia, kneel position work, and articular mobile corpus or juxtra-articular operation or fracture etc. and chronic long stimulate, as overweight, knee joint stimulates by over loading, long-term residence place is moist, paddles in spite of the rain, and weather drastic change is cold and hot to interlock.
Ancient medicine has carried out detailed elaboration to the etiology and pathogenesis of primary disease very early.Say as " a Plain Questions numbness opinion section " " so-called numbness person respectively with at that time, heavy or in the wet gas of wind and cold also "." the wet three air-flow notes of wind and cold be disease also ".All Shen vegetarians then think that " accumulation of heat in knee joint also.Domination of pathogenic heat causing swelling.Swollen very then emaciation cut and knee joint as crane also." Xue oneself think " crane relieve dizziness, high fever, infantile convulsions, epilepsy, etc. for sick, be take good care of oneself inappropriate, loss Three Yin Channels of Foot, ailment said due to cold or exposure is taken advantage of a weak point, so that muscle day is thin, and interior-heat subtracts food, and limbs climb pain, and then knee joint is large and lower limb is thin, as the knee joint of crane for a long time." in sum, primary disease is weak nothing more than bromhidrosis, ailment said due to cold or exposure invades, and hinders meridians, caused by QI and blood is not sought.Should with dredge the meridian passage in treatment, nourishing qi and blood is main.Yang Changqing is from intending Herba Dendrobii profit knee joint soup (being made up of Herba Dendrobii, Radix Rehmanniae Preparata, Fructus Schisandrae Chinensis, Radix Cyathulae, the Radix Astragali, Flos Lonicerae, Poria etc.) treatment 49 routine arthroncus of knee patients, and total effective rate is 93.9%, evident in efficacy.
Application publication number CN102579835A(application number 201110003242.2) Chinese invention patent document disclose a kind of preparation method for the treatment of arthroncus of knee medicine, be made up of the crude drug of following weight portion: Radix Clematidis 50-250g, Caulis Spatholobi 20-500g, Radix Astragali 10-200g, Radix Cyathulae 50-1000g, Radix Polygalae 50-1000g, Herba Dendrobii 10-200g, Flos Lonicerae 20-500g, Radix Glycyrrhizae 5-100g, Mel 1000-5000g.Application publication number CN102406702A(application number 201110391666.0) Chinese invention patent document disclose a kind of Chinese medicine preparation for the treatment of the arthroncus of knee, be made up of the raw material of following parts by weight: Radix Angelicae Pubescentis 3 parts, Radix Cyathulae 3 parts, Herba Epimedii 2 parts, Herba Leonuri 3 parts, Scolopendra 1 part, Hirudo 1 part and Zaocys 1 part.Application publication number CN103463304A(application number 201310412095.3) Chinese invention patent document disclose one and treat arthroncus of knee Chinese medicine, be made up of the raw material of following weight proportion: Scorpio 30-35 gram, Radix Angelicae Dahuricae 30-35 gram, Cortex Cinnamomi 30-35 gram, Cortex Periplocae 30-35 gram, Radix Aconiti Lateralis Preparata 30-35 gram fried by wine, wine Semen Persicae (parched) 30-35 gram, Cortex Lycii 30-35 gram fried by wine, Radix Clematidis 30-35 gram, Herba Erodii 30-35 gram, Radix Achyranthis Bidentatae 30-35 gram, Radix Angelicae Sinensis 30-35 gram, Rhizoma Et Radix Notopterygii 30-35 gram, Radix Paeoniae Alba 30-35 gram, Rhizoma Chuanxiong 30-35 gram, wine Olibanum (parched) 20-30 gram, wine Myrrha (parched) 20-30 gram, Mel 450-550 gram.
At present for the treatment of such disease, Western medicine generally can only take stopgap measures and can not effect a permanent cure, and side effect is large, and life-time service patient body holds be can't stand; Though existing Chinese medicine untoward reaction is less, onset is slow, and the course for the treatment of is long, poor repeatability.
Summary of the invention
For the deficiencies in the prior art, the object of this invention is to provide and a kind ofly prepare simple, that the arthroncus of knee is treated in effect rapidly, safely and effectively Chinese medicine.Chinese medicine determined curative effect of the present invention is convenient to Clinical practice.
Technical scheme of the present invention is:
The Chinese medicine of the treatment arthroncus of knee, is prepared from by following bulk drugs, is weight portion: Cortex Acanthopancis 10-16; Placuna placenta (L.) 3-6; Radix Ardisiae Crenatae 8-12; Araliae cardatae 10-15; Cortex Phellodendri 9-13; Caulis Sinomenii 12-17; Blue pig ear 10-14; Lignum Pini Nodi 6-12; Cacumen et folium sageretiae 8-13; Herba mazi stachydifolii 10-17; Ramulus Mori 9-15; Polyporus 7-14; Folium et cacumen Breyniae Fruticosae 11-16.
In preferred scheme, Cortex Acanthopancis 12-14; Placuna placenta (L.) 4-5; Radix Ardisiae Crenatae 9-11; Araliae cardatae 11.5-13.5; Cortex Phellodendri 10-12; Caulis Sinomenii 13.5-15.5; Blue pig ear 11-13; Lignum Pini Nodi 8-10; Cacumen et folium sageretiae 9.5-11.5; Herba mazi stachydifolii 12-15; Ramulus Mori 11-13; Polyporus 9-12; Folium et cacumen Breyniae Fruticosae 12.5-14.5.
Be more preferably, Cortex Acanthopancis 13; Placuna placenta (L.) 4.5; Radix Ardisiae Crenatae 10; Araliae cardatae 12.5; Cortex Phellodendri 11; Caulis Sinomenii 14.5; Blue pig ear 12; Lignum Pini Nodi 9; Cacumen et folium sageretiae 10.5; Herba mazi stachydifolii 13.5; Ramulus Mori 12; Polyporus 10.5; Folium et cacumen Breyniae Fruticosae 13.5.
The Chinese medicine of the treatment arthroncus of knee, be made into pharmaceutically acceptable pill, preparation method is as follows:
(1) Cortex Phellodendri is cleaned, rough bark of pruning, and the saline solution being placed in 10% soaks 2-5 hour (saline solution being preferably placed in 10% soaks 3.5 hours), and taking-up drains, and put slow fire in parch container and stir-fry to surperficial buff slightly focal spot, taking-up cools, for subsequent use; Placuna placenta (L.) meat is cleaned, and drains away the water, and with the honey spread uniform application of 5%, then bakes to slow fire and processs, treat that Mel is sucked as degree, take out dry, for subsequent use;
(2) Cortex Acanthopancis, Araliae cardatae, blue pig ear, passeris montani saturati sea rattan, Herba mazi stachydifolii and Folium et cacumen Breyniae Fruticosae are placed in traditional Chinese medicine drying case dry, the crude drug taken out after processing with step (1) is placed in pulverizer and is ground into fine powder, sieves, obtains mixed powder for subsequent use;
(3) Radix Ardisiae Crenatae, Caulis Sinomenii, Lignum Pini Nodi, Ramulus Mori and Polyporus are together placed in Chinese medicament extracting device, with the ethanol of 55%-75% for solvent (preferably with 65% ethanol for solvent), heating and refluxing extraction three times, first time extracts 33-47 minute (preferably first time extracts 40 minutes), second time is extracted 25-40 minute (preferably second time is extracted 32 minutes), third time extracts 12-24 minute (preferably third time extracts 18 minutes), merge three extracting solution, filter, filtrate recycling ethanol, being evaporated to 60 DEG C of relative densities is the clear paste of 1.10-1.13, for subsequent use;
(4) in above-mentioned clear paste, add step (2) gained mixed powder, mechanical agitation, add mass fraction be 10% dextrin and mass fraction be the mannitol of 7%, make the pill of Semen Firmianae size, to obtain final product.
The preparation method of the medicine pill of the above-mentioned treatment arthroncus of knee, preferred scheme is, temperature dry in step (2) is 72-84 DEG C (preferred dry temperature is 75-81 DEG C, and the temperature of the drying be more preferably is 78 DEG C).
The preparation method of the medicine pill of the above-mentioned treatment arthroncus of knee, preferred scheme is, the time dry in step (2) is 46-68 minute (the preferred dry time is 52-62 minute, and the time of the drying be more preferably is 57 minutes).
The preparation method of the medicine pill of the above-mentioned treatment arthroncus of knee, preferred scheme is, the middle 75-115 mesh sieve excessively of step (2) (preferred 85-105 mesh sieve excessively, mistake 95 mesh sieve be more preferably).
The preparation method of described water preparation is:
(1) Lignum Pini Nodi smashs into grain of rice size to pieces, is placed in parch container, and slow fire adds to propagandize to surface slightly focal spot hotly, and taking-up cools, for subsequent use; Slender acanthopanax skin graft and yellow wine are mixed thoroughly (Cortex Acanthopancis: yellow wine=25:3), vexed 22-30 minute (preferably vexed 26 minutes), take out dry, for subsequent use;
(2) crude drug after step (1) being processed and Radix Ardisiae Crenatae, Araliae cardatae, Cortex Phellodendri, Caulis Sinomenii, passeris montani saturati sea rattan and Polyporus are together placed in marmite, add the pure water (preferably adding the pure water of 7 times of raw material doses) of 5-9 times of raw material dose, slow fire heating decoction three times, each respectively decoction 32-50 minute (preferably each each decoction 40 minutes), merge three decocting liquids, filter, filtrate is for subsequent use;
(3) Placuna placenta (L.) meat is cleaned, drain away the water, use honey spread uniform application, then bake to slow fire and process, treat that Mel is sucked as degree, take out dry, be placed in medicine pot with blue pig ear, Herba mazi stachydifolii, Ramulus Mori and Folium et cacumen Breyniae Fruticosae, add cold water and do not have powder 3-5cm, intense fire heated and boiled 4-8 minute (preferred intense fire heated and boiled 6 minutes), turn slow fire boiling twice, first time decocts 26-38 minute (preferably first time decocts 32 minutes), and second time decocts 18-30 minute (preferably second time decocts 24 minutes), merges twice decocting liquid, filter, for subsequent use
(4) step (2) and step (3) gained filtrate is merged, be evaporated to the half of original volume, 89-103 DEG C of dry heat sterilization 22-36 minute (preferably 96 DEG C dry heat sterilization 29 minutes), cooling, encapsulates, to obtain final product.
The preparation method of described capsule is:
(1) Lignum Pini Nodi smashs into grain of rice size to pieces, is placed in parch container, and slow fire adds to propagandize to surface slightly focal spot hotly, and taking-up cools, and porphyrize is for subsequent use; Slender acanthopanax skin graft and yellow wine are mixed thoroughly (Cortex Acanthopancis: yellow wine=25:3), vexed 25 minutes, take out and dry, pulverize into fine powder, for subsequent use;
(2) Cortex Phellodendri sheet is placed in parch container, and intense fire is fried to surface coke black (palpus sustainability), and taking-up cools, porphyrize, for subsequent use; Ramulus Mori cuts 2-3cm segment, and the yellow wine being placed in 15% soaks 20-30 minute (yellow wine being preferably placed in 15% soaks 25 minutes), and take out, put in parch container, slow fire heating stir-fries to micro-yellow, and taking-up cools, and is ground into fine powder, for subsequent use;
(3) surplus stock medicine is placed in Chinese medicine pan, add the clear water (preferably adding the clear water of 9 times amount) of 8-10 times amount, soak under room temperature 2-4 hour (soaking 3 hours under preferred room temperature), then intense fire is heated to boil, and turns slow fire boiling twice, each respectively decoction 35-55 minute (preferably each each decoction 45 minutes), filter, merge twice decocting liquid, being evaporated to 80 DEG C of relative densities is the thick paste of 1.25-1.28, for subsequent use;
(4) by step (1) and (2) process after raw material medicated powder join in above-mentioned thick paste, add simultaneously mass fraction be 9% sucrose fine and mass fraction be the microcrystalline Cellulose of 5.5%, mechanical agitation, mix homogeneously, granulate, granulate, dry, cross No. six sieves, incapsulate shell, to obtain final product.
The preparation method of described powder is:
(1) Lignum Pini Nodi smashs into grain of rice size to pieces, is placed in parch container, and slow fire adds to propagandize to surface slightly focal spot hotly, and taking-up cools, and porphyrize is for subsequent use; Slender acanthopanax skin graft and yellow wine are mixed thoroughly (Cortex Acanthopancis: yellow wine=25:3), vexed 25 minutes, take out and dry, pulverize into fine powder, for subsequent use;
(2) Cortex Phellodendri sheet is placed in parch container, and intense fire is fried to surface coke black (palpus sustainability), and taking-up cools, porphyrize, for subsequent use; Ramulus Mori cuts 2-3cm segment, and the yellow wine being placed in 15% soaks 25 minutes, takes out, puts in parch container, and slow fire heating stir-fries to micro-yellow, and taking-up cools, and is ground into fine powder, for subsequent use;
(3) crude drug except step (1) and (2) is placed in drying baker, in 65-75 DEG C of dry 1-2 hour (being preferable over 70 DEG C of dryings 1.5 hours), take out, be ground into fine powder, raw material medicated powder after processing with step (1) and (2) mixes, cross 65-95 mesh sieve (preferred mistake 80 mesh sieve), obtain mixed powder, for subsequent use;
(4) by metering (preferably according to the metering of the 7.5/ bag) subpackage of above-mentioned mixed powder according to 6.5-8.5/ bag, to obtain final product.
Scientific formula of the present invention, preparation method is simple, easy to use, Be very effective.In addition, excellent results of the present invention also shows:
1,the present invention uses theory of Chinese medical science to analyze prescription composition, and according to each physicochemical property of flavour of a drug ingredient and the result of study of pharmacological action, research obtains the preparation method of reasonable, stable active component;
2,this prescription, while reducing swelling and alleviating pain, strengthens dispelling wind dehumidifying, the taste of promoting blood circulation to remove obstruction in the collateral.Selected materials is all Chinese medicine material, without any side effects;
3,medicine of the present invention develops in conjunction with latest modern technological scientific achievement on the basis of traditional tcm syndrome differentiation and treatment, and all medicines share, and has evident in efficacy, safe ready, cheap feature.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
embodiment 1the Chinese medicine of the treatment arthroncus of knee, is prepared from by following bulk drugs, is weight portion (50g/ part): Cortex Acanthopancis 10 parts; Placuna placenta (L.) 3 parts; Radix Ardisiae Crenatae 8 parts; Araliae cardatae 10 parts; Cortex Phellodendri 9 parts; Caulis Sinomenii 12 parts; Blue pig ear 10 parts; Lignum Pini Nodi 6 parts; Cacumen et folium sageretiae 8 parts; Herba mazi stachydifolii 10 parts; Ramulus Mori 9 parts; Polyporus 7 parts; Folium et cacumen Breyniae Fruticosae 11 parts.
The preparation method of the medicine pill of the treatment arthroncus of knee is:
(1) Cortex Phellodendri is cleaned, rough bark of pruning, and the saline solution being placed in 10% soaks 2 hours, and taking-up drains, and put slow fire in parch container and stir-fry to surperficial buff slightly focal spot, taking-up cools, for subsequent use; Placuna placenta (L.) meat is cleaned, and drains away the water, and with the honey spread uniform application of 5%, then bakes to slow fire and processs, treat that Mel is sucked as degree, take out dry, for subsequent use;
(2) Cortex Acanthopancis, Araliae cardatae, blue pig ear, passeris montani saturati sea rattan, Herba mazi stachydifolii and Folium et cacumen Breyniae Fruticosae are placed in traditional Chinese medicine drying case in 72 DEG C of dryings 46 minutes, the crude drug taken out after processing with step (1) is placed in pulverizer and is ground into fine powder, cross 75 mesh sieves, obtain mixed powder for subsequent use;
(3) Radix Ardisiae Crenatae, Caulis Sinomenii, Lignum Pini Nodi, Ramulus Mori and Polyporus are together placed in Chinese medicament extracting device, ethanol with 55% is solvent, heating and refluxing extraction three times, first time extracts 33 minutes, and second time is extracted 25 minutes, third time extracts 12 minutes, merge three extracting solution, filter, filtrate recycling ethanol, being evaporated to 60 DEG C of relative densities is the clear paste of 1.10-1.13, for subsequent use;
(4) in above-mentioned clear paste, add step (2) gained mixed powder, mechanical agitation, add mass fraction be 10% dextrin and mass fraction be the mannitol of 7%, make the pill of Semen Firmianae size, to obtain final product.
The instructions of taking of gained medicine pill of the present invention is: every day three times, each 10-14 ball, and warm water takes, a course for the treatment of two Mondays.
embodiment 2the Chinese medicine of the treatment arthroncus of knee, is prepared from by following bulk drugs, is weight portion (30g/ part): Cortex Acanthopancis 16 parts; Placuna placenta (L.) 6 parts; Radix Ardisiae Crenatae 12 parts; Araliae cardatae 15 parts; Cortex Phellodendri 13 parts; Caulis Sinomenii 17 parts; Blue pig ear 14 parts; Lignum Pini Nodi 12 parts; Cacumen et folium sageretiae 13 parts; Herba mazi stachydifolii 17 parts; Ramulus Mori 15 parts; Polyporus 14 parts; Folium et cacumen Breyniae Fruticosae 16 parts.
The preparation method of the Chinese medicinal aqua of the treatment arthroncus of knee is:
(1) Lignum Pini Nodi smashs into grain of rice size to pieces, is placed in parch container, and slow fire adds to propagandize to surface slightly focal spot hotly, and taking-up cools, for subsequent use; Slender acanthopanax skin graft and yellow wine are mixed thoroughly (Cortex Acanthopancis: yellow wine=25:3), vexed 26 minutes, take out dry, for subsequent use;
(2) crude drug after step (1) being processed and Radix Ardisiae Crenatae, Araliae cardatae, Cortex Phellodendri, Caulis Sinomenii, passeris montani saturati sea rattan and Polyporus are together placed in marmite, add the pure water of 7 times of raw material doses, slow fire heating decoction three times, each each decoction 40 minutes, merge three decocting liquids, filter, filtrate is for subsequent use;
(3) Placuna placenta (L.) meat is cleaned, and drains away the water, uses honey spread uniform application, then bake to slow fire and process, treat that Mel is sucked as degree, take out dry, be placed in medicine pot with blue pig ear, Herba mazi stachydifolii, Ramulus Mori and Folium et cacumen Breyniae Fruticosae, add cold water and do not have powder 3-5cm, intense fire heated and boiled 6 minutes, turn slow fire boiling twice, first time decocts 32 minutes, and second time decocts 24 minutes, merges twice decocting liquid, filter, for subsequent use
(4) step (2) and step (3) gained filtrate is merged, be evaporated to the half of original volume, 96 DEG C of dry heat sterilizations 29 minutes, cooling, encapsulates, to obtain final product.
The instructions of taking of gained Chinese medicinal aqua of the present invention is: every day three times, each 120-150mL, a course for the treatment of two Mondays.
Model case: grandson XX, man, 55 years old, civil servant.Patient is to our hospital in JIUYUE in 2013 22 days.Patient's readme: check out to suffer from the arthroncus of knee when company organization's health check-up last year, right knee joint swelling, pain, limitation of activity, often has feeling of numbness, once takes western medicine, because side effect is obvious, then attempts treatment by Chinese herbs.Introduce by colleague, come my institute and check treatment.Check: patient's arthroncus of knee joints is as the knees of red crowned crane, and limitation of activity, is difficult to bend and stretch, dynamic rut hurt like hell.Knee skin is slightly red, and tenderness is obvious.Body temperature 37 DEG C, right knee joint Zhou Jing grows 1.5 centimetres than left knee joint, red tongue, white and thin fur, wiry and frequent pulse.Be diagnosed as the arthroncus of knee.
Take the Chinese medicinal aqua of the present embodiment gained treatment arthroncus of knee, instructions of taking: every day three times, each 120-150mL, a course for the treatment of two Mondays.After taking two courses for the treatment of, affected part symptom obviously alleviates, and subside a swelling in joint, after continuing to take two courses for the treatment of, symptom all disappears, and freely, fully recover, and drug withdrawal is followed up a case by regular visits to after half a year, without recurrence by patient's self-induction for knee articulation.
embodiment 3the Chinese medicine of the treatment arthroncus of knee, is prepared from by following bulk drugs, is weight portion (45g/ part): Cortex Acanthopancis 12 parts; Placuna placenta (L.) 4 parts; Radix Ardisiae Crenatae 9 parts; Araliae cardatae 11.5 parts; Cortex Phellodendri 10 parts; Caulis Sinomenii 13.5 parts; Blue pig ear 11 parts; Lignum Pini Nodi 8 parts; Cacumen et folium sageretiae 9.5 parts; Herba mazi stachydifolii 12 parts; Ramulus Mori 11 parts; Polyporus 9 parts; Folium et cacumen Breyniae Fruticosae 12.5 parts.
The preparation method of the Chinese medicine capsules of the treatment arthroncus of knee is:
(1) Lignum Pini Nodi smashs into grain of rice size to pieces, is placed in parch container, and slow fire adds to propagandize to surface slightly focal spot hotly, and taking-up cools, and porphyrize is for subsequent use; Slender acanthopanax skin graft and yellow wine are mixed thoroughly (Cortex Acanthopancis: yellow wine=25:3), vexed 25 minutes, take out and dry, pulverize into fine powder, for subsequent use;
(2) Cortex Phellodendri sheet is placed in parch container, and intense fire is fried to surface coke black (palpus sustainability), and taking-up cools, porphyrize, for subsequent use; Ramulus Mori cuts 2-3cm segment, and the yellow wine being placed in 15% soaks 25 minutes, takes out, puts in parch container, and slow fire heating stir-fries to micro-yellow, and taking-up cools, and is ground into fine powder, for subsequent use;
(3) surplus stock medicine is placed in Chinese medicine pan, adds the clear water of 9 times amount, soak 3 hours under room temperature, then intense fire is heated to boil, turn slow fire boiling twice, each each decoction 45 minutes, filters, merge twice decocting liquid, being evaporated to 80 DEG C of relative densities is the thick paste of 1.25-1.28, for subsequent use;
(4) by step (1) and (2) process after raw material medicated powder join in above-mentioned thick paste, add simultaneously mass fraction be 9% sucrose fine and mass fraction be the microcrystalline Cellulose of 5.5%, mechanical agitation, mix homogeneously, granulate, granulate, dry, cross No. six sieves, incapsulate shell, to obtain final product.
The instructions of taking of gained Chinese medicine capsules of the present invention is: every day three times, each 4-6 grain, and warm water takes, a course for the treatment of two Mondays.
embodiment 4the Chinese medicine of the treatment arthroncus of knee, is prepared from by following bulk drugs, is weight portion (35g/ part): Cortex Acanthopancis 14 parts; Placuna placenta (L.) 5 parts; Radix Ardisiae Crenatae 11 parts; Araliae cardatae 13.5 parts; Cortex Phellodendri 12 parts; Caulis Sinomenii 15.5 parts; Blue pig ear 13 parts; Lignum Pini Nodi 10 parts; Cacumen et folium sageretiae 11.5 parts; Herba mazi stachydifolii 15 parts; Ramulus Mori 13 parts; Polyporus 12 parts; Folium et cacumen Breyniae Fruticosae 14.5 parts.
The preparation method of the Chinese medicine powder of the treatment arthroncus of knee is:
(1) Lignum Pini Nodi smashs into grain of rice size to pieces, is placed in parch container, and slow fire adds to propagandize to surface slightly focal spot hotly, and taking-up cools, and porphyrize is for subsequent use; Slender acanthopanax skin graft and yellow wine are mixed thoroughly (Cortex Acanthopancis: yellow wine=25:3), vexed 25 minutes, take out and dry, pulverize into fine powder, for subsequent use;
(2) Cortex Phellodendri sheet is placed in parch container, and intense fire is fried to surface coke black (palpus sustainability), and taking-up cools, porphyrize, for subsequent use; Ramulus Mori cuts 2-3cm segment, and the yellow wine being placed in 15% soaks 25 minutes, takes out, puts in parch container, and slow fire heating stir-fries to micro-yellow, and taking-up cools, and is ground into fine powder, for subsequent use;
(3) crude drug except step (1) and (2) is placed in drying baker, in 70 DEG C of dryings 1.5 hours, take out, be ground into fine powder, the raw material medicated powder after processing with step (1) and (2) mixed, and crossed 80 mesh sieves, obtained mixed powder, for subsequent use;
(4) by the metering, distributing, packaging of above-mentioned mixed powder according to 7.5/ bag, to obtain final product.
The instructions of taking of gained Chinese medicine powder of the present invention is: every day three times, each 1-2 bag, and hot water is taken after mixing it with water, a course for the treatment of two Mondays.
Model case: old XX, female, 63 years old, peasant.Patient is to our hospital on October 6th, 2012.Patient's readme: occurred two gonalgia, swelling without obvious inducement before 2 years, have feeling of numbness, limitation of activity.Be diagnosed as the arthroncus of knee in local hospital inspection, give oral drug therapy.After treating two courses for the treatment of, symptom is not improved.To our hospital after being introduced.Check: the thick distortion of patient two knee joint, flesh are withered bone, limitation of activity, X-ray film prompting knee joint B&J structure Non Apparent Abnormality, red tongue, white and thin fur, slippery and rapid pulse.Be diagnosed as the arthroncus of knee.
Take the Chinese medicine powder of the present embodiment gained treatment arthroncus of knee, instructions of taking: every day three times, each 1-2 bag, hot water is taken after mixing it with water, a course for the treatment of two Mondays.After treating two courses for the treatment of, patient affected part pain obviously alleviates, and swelling is disappeared gradually, and after two courses for the treatment of of continual cure, patient affected part pain and swelling disappear, and two knee joint can stretch, and can squat down, stand.After taking again a course for the treatment of, patient's self-induction is fully recovered, and follow up a case by regular visits to after half a year, patient is without recurrence.
embodiment 5the Chinese medicine of the treatment arthroncus of knee, is prepared from by following bulk drugs, is weight portion (40g/ part): Cortex Acanthopancis 13 parts; Placuna placenta (L.) 4.5 parts; Radix Ardisiae Crenatae 10 parts; Araliae cardatae 12.5 parts; Cortex Phellodendri 11 parts; Caulis Sinomenii 14.5 parts; Blue pig ear 12 parts; Lignum Pini Nodi 9 parts; Cacumen et folium sageretiae 10.5 parts; Herba mazi stachydifolii 13.5 parts; Ramulus Mori 12 parts; Polyporus 10.5 parts; Folium et cacumen Breyniae Fruticosae 13.5 parts.
The preparation method of the medicine pill of the treatment arthroncus of knee is:
(1) Cortex Phellodendri is cleaned, rough bark of pruning, and the saline solution being placed in 10% soaks 3.5 hours, and taking-up drains, and put slow fire in parch container and stir-fry to surperficial buff slightly focal spot, taking-up cools, for subsequent use; Placuna placenta (L.) meat is cleaned, and drains away the water, and with the honey spread uniform application of 5%, then bakes to slow fire and processs, treat that Mel is sucked as degree, take out dry, for subsequent use;
(2) Cortex Acanthopancis, Araliae cardatae, blue pig ear, passeris montani saturati sea rattan, Herba mazi stachydifolii and Folium et cacumen Breyniae Fruticosae are placed in traditional Chinese medicine drying case in 78 DEG C of dryings 57 minutes, the crude drug taken out after processing with step (1) is placed in pulverizer and is ground into fine powder, cross 95 mesh sieves, obtain mixed powder for subsequent use;
(3) Radix Ardisiae Crenatae, Caulis Sinomenii, Lignum Pini Nodi, Ramulus Mori and Polyporus are together placed in Chinese medicament extracting device, ethanol with 65% is solvent, heating and refluxing extraction three times, first time extracts 40 minutes, and second time is extracted 32 minutes, third time extracts 18 minutes, merge three extracting solution, filter, filtrate recycling ethanol, being evaporated to 60 DEG C of relative densities is the clear paste of 1.10-1.13, for subsequent use;
(4) in above-mentioned clear paste, add step (2) gained mixed powder, mechanical agitation, add mass fraction be 10% dextrin and mass fraction be the mannitol of 7%, make the pill of Semen Firmianae size, to obtain final product.
The instructions of taking of gained medicine pill of the present invention is: every day three times, each 10-14 ball, and warm water takes, a course for the treatment of two Mondays.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Cortex Acanthopancis: base is former: be the root bark of Araliaceae slender acanthopanax or Acanthopanax sessiliflorus(Rupr.et Maxim.) Seem., Radix Et Caulis Acanthopanacis Senticosi, rough leaf slender acanthopanax, acanthopanax verticillatus Hao etc.Nature and flavor: pungent, temperature.Gui Jing: enter liver, kidney channel.Function cures mainly: wind-damp dispelling, strengthening bone and muscle, blood circulation and promoting silt.Control anemofrigid-damp arthralgia, muscles and bones contraction is anxious, lumbago, sexual impotence, flaccidity of the lower limbs, children's's walking retardation in children, edema, beriberi, skin ulcer cellulitis toxic swelling, traumatic injury impairment caused by overstrain.
Placuna placenta (L.): base is former: be the meat of Anomiidae animal Placuna placenta (L.).Nature and flavor: salty in the mouth; Cold in nature.Gui Jing: heart channel.Function cures mainly: removing toxic substances; Removing food stagnancy.Main infantile measles; Infantile malnutrition; Wet rotten skin ulcer; The arthroncus of knee.
Radix Ardisiae Crenatae: base is former: be the root of Myrsinacea plant Radix Ardisiae Crenatae or red sunshade.Chemical analysis: the root of Radix Ardisiae Crenatae is containing triterpenoid saponin: Radix Ardisiae Crenatae glycoside, Radix Ardisiae Crenatae Neogroside A, B, Radix Ardisiae Crispae Saponin, and secondary monosaccharide glycoside 3-O-α-L-cyclamin unit A-arabopyranose glycoside, also containing Bergeninum and derivant thereof: 11-O-galloyl Bergeninum, 11-O-Flos Caryophylli acyl group Bergeninum, 11-O-vanilloyl Bergeninum, 11-O-(3 ', 4 '-dimethyl galloyl Bergeninum), nor-Bergeninum, and freidelin, cupreol, Herba Ardisiae Japonicae quinone, daucosterol, chondrillasterol, containing the series fatty acid of 18-30 carbon atom, the cyclodepsipeptide of sucrose and a novelty.Pharmacological action: 1. bacteriostasis 25% decoct in vitro has slight inhibitory action to staphylococcus aureus, escherichia coli, bacillus pyocyaneus.2. the ethanol extraction of antiearly pregnancy effect 60% has antiearly pregnancy effect.Nature and flavor: bitter, pungent, cool in nature.Function cures mainly: heat-clearing and toxic substances removing; Promoting blood circulation and stopping pain.Main laryngopharynx swelling and pain; Beriberoid pyretic arthralgia; Jaundice; Dysentery; Traumatic injury; Erysipelas; Mastitis; Orchitis.
Araliae cardatae: base is former: for Araliaceae eats the root welding technology of upper Radix Angelicae Sinensis, pubescence Radix Ariliae, Radix Ariliae and dense purple Radix Ariliae.Nature and flavor: acrid in the mouth; Bitter; Warm in nature.Gui Jing: return liver; Kidney channel.Function cures mainly: expelling wind and removing dampness; Relaxing muscles and tendons and activating QI and blood in the collateral; Regulating blood flow to alleviate pains.Main rheumatalgia; Soreness of waist and knee joint; Extremity flaccidity syndrome and arthralgia syndrome; Lumbar muscle strain; The arthroncus of knee; Brothers sprain and swell and ache; Fracture; Wind syndrome of head; Headache; Toothache.
Cortex Phellodendri: base is former: this product is the dry bark of rutaceae wampee.Character: this product is en plaque or shallow slot shape.Outer surface yellowish-brown or yellowish-brown, smooth or tool longitudinal furrow stricture of vagina, the visible hole skin trace had and remaining taupe bean sheet jelly; Inner surface dark yellow or light brown, the vertical school stricture of vagina that tool is fine and closely woven.Nature and flavor: bitter, cold.Gui Jing: return kidney, urinary bladder channel.Effect: heat clearing and damp drying, pathogenic fire purging removes steams, detoxification sore treatment.Cure mainly: for damp-heat dysentery, jaundice, leukorrhagia, pyretic stranguria, beriberi ， flaccidity of feet with lamenness, hectic fever due to YIN-deficiency consumptive fever, night sweat, seminal emission, sore swollen toxin, eczema pruritus.Stir-baked CORTEX PHELLODENDRI with salt solution nourishing YIN to lower pathogenic fire.For hyperactivity of fire caused by deficiency of YIN, night sweat hectic fever due to YIN-deficiency.
Caulis Sinomenii: be stem and leaf or the root of Sabiaceae plant Caulis Sinomenii.Chemical analysis: the stem of Sinomenium acutum and root are containing sinomenine, disinomenine, magnoflorine, acutumine, tetrahydrochysene epiberberine, isosinomenine, native Du Laning, sinoacutine, dl-syringaresinol, methyl palmitate, N-demethyl sinacutine, michelalbine, stepharine.Again containing cupreol, stigmasterol.The stem of Sinomenium acutum is containing the first-class multiple alkaloid of sinoacutine.Pharmacological action: 1. to neural effect: (1) analgesic activity: sinomenine, in the test with mice electrostimulation, hot plate method and rabbit photo-thermal stimulus method, all proves the analgesic activity with affirmative.(2) sedation; 2. hypotensive effect: Sinomenium acutum total alkali is to anesthesia or not anaesthesia experiment animal (dog, cat, rabbit, rat), and intravenous injection or gavage all have the acute antihypertensive effect of affirmative, effect rapidly, significantly lasting.3. on the impact of gastrointestinal activity: sinomenine to dog, monkey is oral often slight gastrointestinal untoward reaction; Have inhibitory action in vitro rabbit intestinal and Cavia porcellus intestinal, and can resist pilocarpine, histamine, acetylcholine and barium chloride cause spasm effect.4. antiinflammatory action: sinomenine has significant regressive effect to rat formaldehyde and Ovum Gallus domesticus album " arthritis ", after adrenalectomize or hypophysis, just without this effect.Nature and flavor: bitter are flat.Function cures mainly: wind-damp dispelling, diuresis.Dispelling the wind and dampness pathogens arthralgia pain, the arthroncus of knee, edema, beriberi.
Blue pig ear: base is former: be the herb of goatweed Torenia concolor Lindl..Nature and flavor: sweet in the mouth; Cool in nature.Function cures mainly: clearing away heat-damp and promoting diuresis; Cough-relieving preventing or arresting vomiting.Main jaundice; Stranguria with blood; Vomiting; Diarrhoea; Cough due to pathogenic wind-heat; Traumatic injury; Serpentis hinders; Furunculosis.
Lignum Pini Nodi: base is former: be the tuberosity of the branch of pinaceae plant Pinus tabuliformis, Pinus massoniana Lamb or pinus yunnanensis faranch.Chemical analysis: the main cellulose of Lignum Pini Nodi of Pinus tabuliformis, Pinus massoniana Lamb, lignin, a small amount of volatile oil (Oleum Terebinthinae) and resin; Volatile oil, containing australene and nopinene about more than 90%, separately has a small amount of l-camphene.Nature and flavor: bitter, temperature.Gui Jing: liver; Kidney channel.Function cures mainly: dispeiling pathogenic wind and removing dampness; Channels sootheing and network vessel quickening; Promoting blood circulation and stopping pain.。Main anemofrigid-damp arthralgia, severe and migratory arthralgia pain; Foot numbness flaccidity is soft; Traumatic pain.
Cacumen et folium sageretiae: base is former: be the root of Rhamnaceae plant Cacumen et folium sageretiae.Nature and flavor: sweet; Light; Flat.Gui Jing: lung; Kidney channel.Function cures mainly: sending down the abnormal ascending QI; Reduce phlegm; Expelling wind and removing dampness.Main cough; Asthma; Stomachache; The arthroncus of knee; Edema.
Herba mazi stachydifolii: base is former: be the herb of goatweed Herba mazi stachydifolii.Nature and flavor: taste is micro-pungent; Cool in nature.Function cures mainly: heat-clearing and toxic substances removing; Cool the blood dissipate blood stasis.Main constipation hematochezia; Furuncle toxic swelling; Venom; Traumatic injury.
Ramulus Mori: base is former: be the twig of moraceae plants Mulberry.Chemical analysis: Ramulus Mori contains tannin, sucrose, fructose, stachyose, glucose, maltose, Raffinose, arabinose, xylose; Stem contains flavones ingredient: Sang Su, mulberrochromene, cyclomulberrin, cyclomulberrochromene.Timber is containing morin, and three-bristle cudrania tree is plain, 2,4,4 ', 6-tetrahydroxybenzophenone, 2,3 ', 4,4 ', 6-pentahydroxybenzophenone; Heartwood contains Dihydromorin., Dihydrokaempferol, 2,4,3 ', 5 '-tetrahydroxystilbene, Morus alba eight alcohol.Nature and flavor: bitter; Property is put down.Gui Jing: Liver Channel.Function cures mainly: wind-damp dispelling; The meridian dredging; Row aqueous vapor.Main air pain of dampness syndrome; Apoplexy and hemiplegia; Edema foot gas; Human body pruritus due to wind pathogen.
Polyporus: base is former: this product is the dry sclerotia of On Polyporaceae Polyporus.Chemical analysis: containing ergosterol, biotin, saccharide, protein.Nature and flavor: sweet, light are flat.Gui Jing: return kidney, urinary bladder channel.Effect: promoting diuresis to eliminate damp pathogen.Cure mainly: for dysuria, edema, have loose bowels, stranguria with turbid discharge, leukorrhagia.
Folium et cacumen Breyniae Fruticosae: base is former: be the browse of euphorbia plant Folium et cacumen Breyniae Fruticosae.Chemical analysis: branch, leaf and peel of stem are all containing tannin, and in peel of stem, content is 12.02%.Leaf is containing phenols and triterpene.The fatty oil of seed.Pharmacological action: antibacterial action.The dilution of 1:1200 Fruticose Breyniae Leaf and Twig fluid extract is dense all has very strong bacteriostasis to staphylococcus aureus, bacillus pyocyaneus, escherichia coli, shigella flexneri, alpha streptococcus in vitro, may with wherein contained tannin is relevant.Nature and flavor: mildly bitter flavor; Cool in nature poisonous.Gui Jing: large intestine; Liver Channel.Function cures mainly: clearing heat and expelling damp; Promoting blood circulation and detoxication.Main stomachache is vomited and diarrhoea; Eczema; Herpes zoster; Dermatitis; Dermatitis rhus; Rheumatic arthralgia; Puerperal galactostasis; Pudendal pruritus.
test example 1the clinical practice of the Chinese medicine (embodiment 5) of the gained treatment arthroncus of knee of the present invention:
1, data and method
1.1 physical data
In October ,-2013 in May, 2010, screen 300 routine arthroncus of knee patients in four hospitals, the age 45-75 year, 60.5 ± 3.5 years old mean age, wherein male 179 example, women 121 example; All patients are at the age, and the aspect such as the state of an illness, the course of disease is through statistical procedures, and no significant difference (P > 0.05), has comparability.
1.2 Therapeutic Method
All patients are divided into experimental group and matched group at random, and experimental group takes products obtained therefrom of the present invention, instructions of taking: "
Matched group takes other medicines (as peony root total glycosides capsules, closing the conventional medication such as Zhi Ling, ibuprofen granule).Observe four courses for the treatment of of treatment altogether.
1.3 curative effect determinate standard
Clinical cure: clinical symptoms and sign all disappear, functional activity recovers normal; Main physico-chemical examination index is normal.
Effective: symptomatology is eliminated or cardinal symptom is eliminated, and function of joint is recovered substantially, normal work or physical labor can be participated in; Physico-chemical examination index is normal.
Effective: clinical symptoms is eliminated substantially, major joint function is substantially recovered or is had made marked progress, and main physico-chemical examination index makes moderate progress.
Invalid: clinical symptoms and sign is unchanged or comparatively treatment before increase the weight of.
Total effective rate=(clinical cure number of cases+effective number of cases+effectively number of cases) ∕ total inspection case load × 100%.
1.4 therapeutic outcome
Experimental group and treatment of control group result, as shown in table 1:
Table 1: the therapeutic outcome of experimental group and matched group compares
Therapeutic effect: experimental group clinical cure 129 example (64.5%), effective 43 examples (21.5%), effective 25 examples (12.5%), invalid 3 examples (1.5%), total effective rate 98.5%.Successful is better than matched group.
The present invention select Cortex Acanthopancis, Placuna placenta (L.), Radix Ardisiae Crenatae, Araliae cardatae, Cortex Phellodendri, Caulis Sinomenii, blue pig ear, Lignum Pini Nodi and Cacumen et folium sageretiae etc. totally 13 taste primary raw material medicines be prepared from.Fang Zhong, Cortex Acanthopancis wind-damp dispelling, strengthening bone and muscle, blood circulation and promoting silt; Placuna placenta (L.) detoxifies, removing food stagnancy; Radix Ardisiae Crenatae heat-clearing and toxic substances removing, promoting blood circulation and stopping pain; Araliae cardatae expelling wind and removing dampness, relaxing muscles and tendons and activating QI and blood in the collateral, regulating blood flow to alleviate pains; Cortex Phellodendri heat clearing and damp drying, pathogenic fire purging removes steams, detoxification sore treatment; Caulis Sinomenii wind-damp dispelling, diuresis; Lignum Pini Nodi dispeiling pathogenic wind and removing dampness, channels sootheing and network vessel quickening, promoting blood circulation and stopping pain; Herba mazi stachydifolii heat-clearing and toxic substances removing, cool the blood dissipate blood stasis; Polyporus promoting diuresis to eliminate damp pathogen; Folium et cacumen Breyniae Fruticosae clearing heat and expelling damp, promoting blood circulation and detoxication.All medicines share, altogether long memorial wind dampness removing, channels sootheing and network vessel quickening, effect of promoting blood circulation and stopping pain.After treating four courses for the treatment of, treatment group effective percentage can reach 98.5%, and matched group is only 79%.
It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or according to undoubted the obtaining of the written description of file, the claimed scope of this patent all should be thought.
Claims (10)
1. treat the Chinese medicine of the arthroncus of knee, it is characterized in that, be prepared from by following bulk drugs, be weight portion: Cortex Acanthopancis 10-16; Placuna placenta (L.) 3-6; Radix Ardisiae Crenatae 8-12; Araliae cardatae 10-15; Cortex Phellodendri 9-13; Caulis Sinomenii 12-17; Blue pig ear 10-14; Lignum Pini Nodi 6-12; Cacumen et folium sageretiae 8-13; Herba mazi stachydifolii 10-17; Ramulus Mori 9-15; Polyporus 7-14; Folium et cacumen Breyniae Fruticosae 11-16.
2. the Chinese medicine of the treatment arthroncus of knee as claimed in claim 1, is characterized in that, be prepared from by following bulk drugs, be weight portion: Cortex Acanthopancis 12-14; Placuna placenta (L.) 4-5; Radix Ardisiae Crenatae 9-11; Araliae cardatae 11.5-13.5; Cortex Phellodendri 10-12; Caulis Sinomenii 13.5-15.5; Blue pig ear 11-13; Lignum Pini Nodi 8-10; Cacumen et folium sageretiae 9.5-11.5; Herba mazi stachydifolii 12-15; Ramulus Mori 11-13; Polyporus 9-12; Folium et cacumen Breyniae Fruticosae 12.5-14.5.
3. the Chinese medicine of the treatment arthroncus of knee as claimed in claim 1, is characterized in that, be prepared from by following bulk drugs, be weight portion: Cortex Acanthopancis 13; Placuna placenta (L.) 4.5; Radix Ardisiae Crenatae 10; Araliae cardatae 12.5; Cortex Phellodendri 11; Caulis Sinomenii 14.5; Blue pig ear 12; Lignum Pini Nodi 9; Cacumen et folium sageretiae 10.5; Herba mazi stachydifolii 13.5; Ramulus Mori 12; Polyporus 10.5; Folium et cacumen Breyniae Fruticosae 13.5.
4. the Chinese medicine of the treatment arthroncus of knee as described in as arbitrary in claim 1-3, it is characterized in that, be made into pharmaceutically acceptable pill, preparation method is as follows:
(1) Cortex Phellodendri is cleaned, rough bark of pruning, and the saline solution being placed in 10% soaks 2-5 hour (saline solution being preferably placed in 10% soaks 3.5 hours), and taking-up drains, and put slow fire in parch container and stir-fry to surperficial buff slightly focal spot, taking-up cools, for subsequent use; Placuna placenta (L.) meat is cleaned, and drains away the water, and with the honey spread uniform application of 5%, then bakes to slow fire and processs, treat that Mel is sucked as degree, take out dry, for subsequent use;
(2) Cortex Acanthopancis, Araliae cardatae, blue pig ear, passeris montani saturati sea rattan, Herba mazi stachydifolii and Folium et cacumen Breyniae Fruticosae are placed in traditional Chinese medicine drying case dry, the crude drug taken out after processing with step (1) is placed in pulverizer and is ground into fine powder, sieves, obtains mixed powder for subsequent use;
(3) Radix Ardisiae Crenatae, Caulis Sinomenii, Lignum Pini Nodi, Ramulus Mori and Polyporus are together placed in Chinese medicament extracting device, with the ethanol of 55%-75% for solvent (preferably with 65% ethanol for solvent), heating and refluxing extraction three times, first time extracts 33-47 minute (preferably first time extracts 40 minutes), second time is extracted 25-40 minute (preferably second time is extracted 32 minutes), third time extracts 12-24 minute (preferably third time extracts 18 minutes), merge three extracting solution, filter, filtrate recycling ethanol, being evaporated to 60 DEG C of relative densities is the clear paste of 1.10-1.13, for subsequent use;
(4) in above-mentioned clear paste, add step (2) gained mixed powder, mechanical agitation, add mass fraction be 10% dextrin and mass fraction be the mannitol of 7%, make the pill of Semen Firmianae size, to obtain final product.
5. the preparation method of the medicine pill of the treatment arthroncus of knee according to claim 4, is characterized in that, temperature dry in step (2) is 72-84 DEG C (preferred dry temperature is 75-81 DEG C, and the temperature of the drying be more preferably is 78 DEG C).
6. the preparation method of the medicine pill of the treatment arthroncus of knee according to claim 4, is characterized in that, the time dry in step (2) is 46-68 minute (the preferred dry time is 52-62 minute, and the time of the drying be more preferably is 57 minutes).
7. the preparation method of the medicine pill of the treatment arthroncus of knee according to claim 4, is characterized in that, the middle 75-115 mesh sieve excessively of step (2) (preferred 85-105 mesh sieve excessively, mistake 95 mesh sieve be more preferably).
8. the Chinese medicine of the treatment arthroncus of knee as described in as arbitrary in claim 1-3, it is characterized in that, be made into pharmaceutically acceptable water preparation, preparation method is as follows:
(1) Lignum Pini Nodi smashs into grain of rice size to pieces, is placed in parch container, and slow fire adds to propagandize to surface slightly focal spot hotly, and taking-up cools, for subsequent use; Slender acanthopanax skin graft and yellow wine are mixed thoroughly (Cortex Acanthopancis: yellow wine=25:3), vexed 22-30 minute (preferably vexed 26 minutes), take out dry, for subsequent use;
(2) crude drug after step (1) being processed and Radix Ardisiae Crenatae, Araliae cardatae, Cortex Phellodendri, Caulis Sinomenii, passeris montani saturati sea rattan and Polyporus are together placed in marmite, add the pure water (preferably adding the pure water of 7 times of raw material doses) of 5-9 times of raw material dose, slow fire heating decoction three times, each respectively decoction 32-50 minute (preferably each each decoction 40 minutes), merge three decocting liquids, filter, filtrate is for subsequent use;
(3) Placuna placenta (L.) meat is cleaned, drain away the water, use honey spread uniform application, then bake to slow fire and process, treat that Mel is sucked as degree, take out dry, be placed in medicine pot with blue pig ear, Herba mazi stachydifolii, Ramulus Mori and Folium et cacumen Breyniae Fruticosae, add cold water and do not have powder 3-5cm, intense fire heated and boiled 4-8 minute (preferred intense fire heated and boiled 6 minutes), turn slow fire boiling twice, first time decocts 26-38 minute (preferably first time decocts 32 minutes), and second time decocts 18-30 minute (preferably second time decocts 24 minutes), merges twice decocting liquid, filter, for subsequent use
(4) step (2) and step (3) gained filtrate is merged, be evaporated to the half of original volume, 89-103 DEG C of dry heat sterilization 22-36 minute (preferably 96 DEG C dry heat sterilization 29 minutes), cooling, encapsulates, to obtain final product.
9. the Chinese medicine of the treatment arthroncus of knee as described in as arbitrary in claim 1-3, it is characterized in that, be made into pharmaceutically acceptable capsule, preparation method is as follows:
(1) Lignum Pini Nodi smashs into grain of rice size to pieces, is placed in parch container, and slow fire adds to propagandize to surface slightly focal spot hotly, and taking-up cools, and porphyrize is for subsequent use; Slender acanthopanax skin graft and yellow wine are mixed thoroughly (Cortex Acanthopancis: yellow wine=25:3), vexed 25 minutes, take out and dry, pulverize into fine powder, for subsequent use;
(2) Cortex Phellodendri sheet is placed in parch container, and intense fire is fried to surface coke black (palpus sustainability), and taking-up cools, porphyrize, for subsequent use; Ramulus Mori cuts 2-3cm segment, and the yellow wine being placed in 15% soaks 20-30 minute (yellow wine being preferably placed in 15% soaks 25 minutes), and take out, put in parch container, slow fire heating stir-fries to micro-yellow, and taking-up cools, and is ground into fine powder, for subsequent use;
(3) surplus stock medicine is placed in Chinese medicine pan, add the clear water (preferably adding the clear water of 9 times amount) of 8-10 times amount, soak under room temperature 2-4 hour (soaking 3 hours under preferred room temperature), then intense fire is heated to boil, and turns slow fire boiling twice, each respectively decoction 35-55 minute (preferably each each decoction 45 minutes), filter, merge twice decocting liquid, being evaporated to 80 DEG C of relative densities is the thick paste of 1.25-1.28, for subsequent use;
(4) by step (1) and (2) process after raw material medicated powder join in above-mentioned thick paste, add simultaneously mass fraction be 9% sucrose fine and mass fraction be the microcrystalline Cellulose of 5.5%, mechanical agitation, mix homogeneously, granulate, granulate, dry, cross No. six sieves, incapsulate shell, to obtain final product.
10. the Chinese medicine of the treatment arthroncus of knee as described in as arbitrary in claim 1-3, it is characterized in that, be made into pharmaceutically acceptable powder, preparation method is as follows:
(1) Lignum Pini Nodi smashs into grain of rice size to pieces, is placed in parch container, and slow fire adds to propagandize to surface slightly focal spot hotly, and taking-up cools, and porphyrize is for subsequent use; Slender acanthopanax skin graft and yellow wine are mixed thoroughly (Cortex Acanthopancis: yellow wine=25:3), vexed 25 minutes, take out and dry, pulverize into fine powder, for subsequent use;
(2) Cortex Phellodendri sheet is placed in parch container, and intense fire is fried to surface coke black (palpus sustainability), and taking-up cools, porphyrize, for subsequent use; Ramulus Mori cuts 2-3cm segment, and the yellow wine being placed in 15% soaks 25 minutes, takes out, puts in parch container, and slow fire heating stir-fries to micro-yellow, and taking-up cools, and is ground into fine powder, for subsequent use;
(3) crude drug except step (1) and (2) is placed in drying baker, in 65-75 DEG C of dry 1-2 hour (being preferable over 70 DEG C of dryings 1.5 hours), take out, be ground into fine powder, raw material medicated powder after processing with step (1) and (2) mixes, cross 65-95 mesh sieve (preferred mistake 80 mesh sieve), obtain mixed powder, for subsequent use;
(4) by metering (preferably according to the metering of the 7.5/ bag) subpackage of above-mentioned mixed powder according to 6.5-8.5/ bag, to obtain final product.
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| CN107669913A (en) * | 2017-11-23 | 2018-02-09 | 马雪英 | A kind of medicine for treating the arthroncus of knee and preparation method thereof |
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