CN106038981A

CN106038981A - Traditional Chinese medicine composition for treating yin deficiency blood heat type painful heel

Info

Publication number: CN106038981A
Application number: CN201610541723.1A
Authority: CN
Inventors: 马佳
Original assignee: Individual
Current assignee: Individual
Priority date: 2016-07-10
Filing date: 2016-07-10
Publication date: 2016-10-26

Abstract

The invention provides traditional Chinese medicines for treating the yin deficiency blood heat type painful heel. The oral medicine is prepared from 10-20 parts of radix paeoniae alba, 10-20 parts of cortex lycii radicis, 10-20 parts of radix ophiopogonis, 10-20 parts of radix rehmanniae preparata, 10-20 parts of cortex phellodendri, 10-20 parts of radix polygoni multiflori preparata, 10-20 parts of radix achyranthis bidentatae, 10-20 parts of flos carthami, 10-20 parts of fructus lycii, 10-20 parts of cortex moutan, 10-20 parts of herba ecliptae, 10-20 parts of agrimonia pilosa ledeb, 10-20 parts of rhizoma anemarrhenae, 10-20 parts of drynaria rhizome, 10-20 parts of eucommia ulmoides, 10-20 parts of rhizoma corydalis and 10-20 parts of caulis spatholobi. The external use medicine is prepared from, by weight, 10-20 parts of dipsacus roots, 10-20 parts of radix angelicae, 10-20 parts of bletilla striata, 10-20 parts of rhizoma chuanxiong, 10-20 parts of phryma leptostachya, 10-20 parts of pseudo-ginseng, 10-20 parts of frankincense, 10-20 parts of myrrh, 10-20 parts of notopterygium roots, 10-20 parts of folium artemisiae argyi, 10-20 parts of radix clematidis and 10-20 parts of radix saposhnikoviae. Symtoms are relieved or eliminated.

Description

A kind of Chinese medicine composition treating YinXuXueRe type talalgia and preparation method thereof

Technical field

The present invention relates to, containing the pharmaceutical product deriving from plant, animal or mineral component, treat particularly to one Chinese medicine composition of YinXuXueRe type talalgia and preparation method thereof.

Background technology

Heel one or both sides pain, the reddest pneumonedema, walking disorder.Also known as relieving heel pain.It is the sclerotin due to heel, pass The disease that joint, synovial bursa, fascia etc. pathological changes causes.Common for plantar fasciitis, it is frequently experienced in standing for a long time or walking worker, long Phase, chronic slight wound cause, and show as sole of the foot fascia fibrous fracture and repair process, and below calcaneus, the fascia of inner side is depended on locate bone partially Matter hypertrophy and tenderness, position, side X-ray sheet display calcanean spur.But having bony spur not necessarily to have talalgia, plantar fasciitis is not necessarily There is bony spur.Chinese medicine is thought, talalgia many genus hepatic and renal YIN deficiency, phlegm-damp, heat in blood etc. are because of caused.Liver governing tendons, kidney governing bones, Liver and kidney loses Void, muscles and bones is lost foster, and sense wind-cold damp pathogen or chronic strain just cause meridian stasis stagnant again, and QI-blood circulation is obstructed, and makes muscles and bones muscle lose and supports And fall ill.

The modal reason of talalgia is that long-term, chronic, microtrauma accumulates the pathological changes caused, and shows as fascia fiber Fracture and repair process thereof.Below calcaneus partially in fascia vicinity can have a hyperosteogeny, form bone ridge.At position, side roentgenogram Bony spur it is shown as on sheet.The latter is considered as often the reason of talalgia, but clinical research proves the cause effect relation of it and talalgia Being difficult to certainly, plantar fasciitis differs and establishes a capital with bony spur, has the people of calcanean spur also to differ and established a capital talalgia.Plantar fasciitis draws The talalgia risen can be cured naturally.Padded heel, alleviates the heel string pulling force to calcaneus, front plantar flexion of foot, alleviates opening of sole of the foot fascia Power, all can make symptom alleviate.Injection of drug can be carried out by local pressure pain point inside foot root, once in a week, most after injection Patient can cure in two weeks.

With pad pain often occurs old people, it is to be interval by fibrous tissue below calcaneus with pad, with fatty tissue and elastic force Fibroplastic elastic insert；Nonage, with pad resilient beam, can absorb vibration.Time old, with pad elastic force declines, calcaneus In the case of linerless, undertake body weight, cicatrix and calcium deposition can be formed time serious, cause talalgia.With pad pain and sole of the foot fascia Scorching different, below whole heel, there is tenderness.Therapeutic Method is for using sponge with pad or topical remedy's injection.

After calcaneus the most easily there is the synovial bursa between heel string and skin in bursitis, by inappropriate high heel leather shoes frictionally damage Cause.The variable plumpness of synovial bursa wall, is full of synovial fluid, local swelling, and has tenderness in capsule.Therapeutic Method preferably improves footwear type.If synovial bursa Swelling does not disappears, and can puncture attraction, and can inject hydrocortisone.

Calcaneal apophysitis often betides the boy of 8～12 years old, and pathological changes is similar to calf shank tuberosity apophysitis, is to grow During, the symptom that the epiphysis not healed is caused by tendon tractive, pain, below heel string attachment point, can be fallen ill by bilateral simultaneously. Run and standing on tiptoe can make exacerbation of symptoms.Symptom Lock-out after osteophiphysis.Typically make anti symptom treatment, infant can be made to alleviate Movable, it is also possible to pad alleviates the heel string pulling force to calcaneus.

Astragalus hypozygal is scorching often to be occurred after fracture of calcaneus, is a kind of traumatic arthritis.X-ray photographs is gone forward instep hole Place, during heavy burden, pain increases the weight of.If expectant treatment lost efficacy, then should carry out talocalcaneal joint fusion.

Old fracture of calcaneus or rare calcaneus tumor or tuberculosis are also the reasons of talalgia.Illness beyond heel is drawn Play calcaneodynia person, have rheumatoid spondylitis, the prolapse of lumbar intervertebral disc of compressing sacral nerve roots, occur the tibial nerve at shank to extrude Deng.

The most how to distinguish is the talalgia that causes of which kind of reason？In general, except by means of the most auxiliary Help inspection as outside X-ray, mainly by the sufficient section doctor of specialty, have a medical check-up through clinic, substantially can clarify a diagnosis.Can also apply Therapeutic means are distinguished, the talalgia that such as old people causes due to vola fat pad atrophy, when application local block therapy Time, it is of no curative effect.

Talalgia often shows as first and second step landed pain of getting up morning, just can gradually alleviate after walking a few step.Heel Pain is divided into two kinds: one is true property talalgia, and X-ray confirms to truly have the formation of calcanean spur, pain spot to concentrate；Another kind is false Talalgia, X-ray does not has the formation of bony spur hypertrophy, heel portion constant pain, and both legs have heavy weak sense.Two kinds of talalgia are mutual Any association is not had between Xiang.

From the angle analysis of the traditional Chinese medical science, talalgia belongs to the one of rheumatism involving the bone, how because of the hepatic and renal YIN deficiency, caused by cold-evil.Talalgia is A kind of disease that old people is common, but the sickness rate in young woman rises year by year now, particularly as white collar clan, on The cooling slippers of fashion style is worn by class, and heel minister's phase exposes, and easily by attacked by the cold and evil in air-conditioned room, is After Hours busy with strolling Street, jumping slimnastics, foot fails again well to be had a rest, and due to the long-term pressurized of heel, hyperkinesia with have a cold, causes foot With fat fiber mat aseptic inflammation, finally induce pain.

False talalgia is preventable, notes the warming of heel portion at ordinary times, it is to avoid excessively walk or stand, can before sleeping Using warm water foot bath, or foot is given hot compress, soft sole is worn in selection the most as far as possible, as sarapus, more it is noted that avoided Degree motion, preferably can also put on corrective shoes.

Puerpera in puerperal period, QI and blood deficiency, it is easy to cold gas of suffering from cold.Particularly foot, including heel, is once subject to Cool, arise that pain in the date afterwards.Puerperal, talalgia was deficient syndrome, was not wound, was also not belonging to caused by bony spur.This Puerperal disease, to suffer from a deficiency of the kidney, puerperal wears high heels, and wears slippers, sandals the most barefoot, may often be such that important inducement.

Kidney is unit's the dominator of QI, kidney governing reproduction, main bone.According to meridians circulation route, heel belongs to the scope of kidney channel circulation.Heel Pain is a kind of commonly encountered diseases, is characterized with heel swelling, numb pain, locally tenderness, difficulty in walking.Talalgia is also known as calcanean spur Or heel bone hyperosteogeny.Belonging to " rheumatism involving the bone " category in Chinese medicine, pathogenic factor is many strains with old deficiency of the kidney, wound and experience cold-damp Relevant.With the passing of time or from the beginning of talalgia, select the herbal medicine immersion of numerous expelling wind and removing dampness, dispelling cold by warming the meridian, softening hardness and disperse swelling, invigorating blood circulation analgesia Or external application foot, not injured skin, without toxicity.

Traditional Chinese Medicine early has research to the disease of talalgia, and Sui Dynasty famous physician Chao Yuanfang (550-630 A.D.) talalgia is called " heel is ruined ", Book cloud: " heel ruined person heel neglect pain, must not also, common customs are exhaled as heel ruined." the big physician Zhu Dan of one of Au element Small stream is referred to as " talalgia " in " danxi's experiential therapy ", it is necessary to use the attached cream in osmanthus.The Qing Dynasty's famous physician Xu Ling tire is said: " modern used Plaster, the plaster applying a plaster for therapeutic purpose of ancients' meaning..... control inner person, or wind dispelling trembled with fear, or and QI and blood, or expectorant painful abdominal mass, or strengthening bone and muscle, its side is very clever, Medicine is also added and subtracted with disease, and its cream preferably weighs thick patch for a long time.”

YinXuXueRe refers to due to internal cloudy liquid virtual loss, the heating card caused by water failing to restrain blazing fire.Disease sees that two flushed cheeks are red, and body disappears Thin, hectic fever night sweat, dysphoria with feverish sensation in the chest palms and soles, night fever abating at dawn, dryness of the mouth and throat, the few tongue of red tongue, thready and rapid pulse.Control suitable replenishing YIN and removing heat, or YIN nourishing fall Fire.YinXuXueRe, blood and essence asthenia, passages through which vital energy circulates loses and fills, then muscle is become homeless foster, and bone is become homeless master, and bone withers flaccidity of tendon and muscle, foot shin intermittent fever and talalgia, Therefore when standing or walk heel ache, dull pain, weak, pain pain relieved by pressing, the alleviation of pain touched.

Western medicine therapy

Operative treatment: 1. spur in heels excision, for intractable macLean-Maxwell disease, X sheet confirms there is bony spur person, inside calcaneus Make a kerf, enter calcaneus, operative treatment talalgia bony spur inside calcaneus is all filed and removes.

2. calcaneus Drilling: high person intrinsic pressure to calcaneus is suitable for, it is therefore an objective to make the intrinsic pressure reduction of calcaneus increased, treats intractable Without the calcaneodynia of bony spur, still at calcaneus inner incision, after reaching calcaneus, by calcaneus drilling on inner side 7～10, effect reaches 90%.

3. calcaneus neurotomy: for this method can be used without reason intractable talalgia, but be a kind of destructive hands Art, props up calcaneus posterior tibial nerve and props up cut-out with sural nerve.

4. calcaneus Synovectomy: be that synovial bursa under calcaneal tuberosity synovial bursa and calcaneus is excised.

5. the osteotomy of calcaneus art of flat foot: purpose is to make calcaneus angle increase by osteotomy of calcaneus, and the calcaneus turned up is ajusted, and makes Calcaneus has a good biological support.

Doctor trained in Western medicine typically solves this problem with operation, though there being certain curative effect, but plants destructive operation, by calcaneus posterior tibial nerve Prop up and sural nerve props up cut-out, have side effect in various degree or cause some complication；Chinese medicine product is then because of its sky of drawing materials So, safety side effect good, low, documents and materials are abundant, clinical efficacy is good and enjoys favor.But existing prescription specific aim is poor, Can not fundamentally alleviate the symptom of talalgia, and the most certain side effect.Therefore, the Chinese medicine of a kind of highly effective and safe is found Compositions becomes the urgent needs of people.

Summary of the invention

The technical problem to be solved is, talalgia is a kind of commonly encountered diseases, with heel swelling, numb pain, Locally tenderness, difficulty in walking are characterized.Talalgia is also known as calcanean spur or heel bone hyperosteogeny." rheumatism involving the bone " model is belonged in Chinese medicine Farmland, pathogenic factor is many strains with old deficiency of the kidney, and wound is with to experience cold-damp relevant.YinXuXueRe refers to due to internal cloudy liquid virtual loss, water Heating card caused by fire the most processed.Disease sees that two flushed cheeks are red, emaciated physique, hectic fever night sweat, dysphoria with feverish sensation in the chest palms and soles, night fever abating at dawn, dryness of the mouth and throat, The few tongue of red tongue, thready and rapid pulse.Control suitable replenishing YIN and removing heat, or nourishing YIN to lower pathogenic fire.Deficiency of the liver and kindey, blood and essence asthenia, passages through which vital energy circulates loses and fills, then muscle is become homeless Supporting, bone is become homeless master, and bone withers flaccidity of tendon and muscle, thus when standing or walk heel ache, dull pain, weak, pain pain relieved by pressing, the alleviation of pain touched.

For solving these technical barriers, the invention provides a kind of Chinese medicine composition treating YinXuXueRe type talalgia, Its described Chinese medicine composition is made up of with external used medicine endo-medicine, and endo-medicine can include the raw material of following parts by weight Medicine: the Radix Paeoniae Alba 10～20 parts, Cortex Lycii 10～20 parts, Radix Ophiopogonis 10～20 parts, Radix Rehmanniae Preparata 10～20 parts, Cortex Phellodendri 10～20 parts, Radix Polygoni Multiflori Preparata 10～20 parts, Radix Achyranthis Bidentatae 10～20 parts, Flos Carthami 10～20 parts, Fructus Lycii 10～20 parts, Cortex Moutan 10～20 parts, Herba Ecliptae 10～20 parts, Herba Agrimoniae 10～20 parts, the Rhizoma Anemarrhenae 10～20 parts, Rhizoma Drynariae 10～20 parts, the Cortex Eucommiae 10～20 parts, Rhizoma Corydalis 10～20 parts, Caulis Spatholobi 10～20 parts.

Described Chinese medicine composition external used medicine can include the crude drug of following parts by weight: Radix Dipsaci 10～20 parts, the Radix Angelicae Dahuricae 10～20 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 10～20 parts, Rhizoma Chuanxiong 10～20 parts, Herba speranskiae tuberculatae 10～20 parts, Radix Notoginseng 10～20 parts, Olibanum 10～20 parts, Myrrha 10～20 parts, Rhizoma Et Radix Notopterygii 10～20 parts, Folium Artemisiae Argyi 10～20 parts, Radix Clematidis 10～20 parts, Radix Saposhnikoviae 10～20 parts.

The Chinese medicine composition of described treatment YinXuXueRe type talalgia, in its described Chinese medicine composition, endo-medicine is all right Crude drug including following parts by weight: the Radix Paeoniae Alba 10～15 parts, Cortex Lycii 10～15 parts, Radix Ophiopogonis 10～15 parts, Radix Rehmanniae Preparata 10～15 Part, Cortex Phellodendri 10～15 parts, Radix Polygoni Multiflori Preparata 10～15 parts, Radix Achyranthis Bidentatae 10～15 parts, Flos Carthami 10～15 parts, Fructus Lycii 10～20 parts, Cortex Moutan 10 ～20 parts, Herba Ecliptae 10～20 parts, Herba Agrimoniae 10～20 parts, the Rhizoma Anemarrhenae 10～20 parts, Rhizoma Drynariae 10～20 parts, the Cortex Eucommiae 10～20 Part, Rhizoma Corydalis 10～20 parts, Caulis Spatholobi 10～20 parts.

In described Chinese medicine composition, external used medicine can also include the crude drug of following parts by weight: Radix Dipsaci 10～15 parts, The Radix Angelicae Dahuricae 10～15 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 10～15 parts, Rhizoma Chuanxiong 10～15 parts, Herba speranskiae tuberculatae 10～15 parts, Radix Notoginseng 10～15 parts, Olibanum 10～20 Part, Myrrha 10～20 parts, Rhizoma Et Radix Notopterygii 10～20 parts, Folium Artemisiae Argyi 10～20 parts, Radix Clematidis 10～20 parts, Radix Saposhnikoviae 10～20 parts.

The Chinese medicine composition of described treatment YinXuXueRe type talalgia, in its described Chinese medicine composition, endo-medicine can also Crude drug including following parts by weight: the Radix Paeoniae Alba 10～20 parts, Cortex Lycii 10～20 parts, Radix Ophiopogonis 10～20 parts, Radix Rehmanniae Preparata 10～20 Part, Cortex Phellodendri 10～20 parts, Radix Polygoni Multiflori Preparata 10～20 parts, Radix Achyranthis Bidentatae 10～20 parts, Flos Carthami 10～20 parts, Fructus Lycii 10～15 parts, Cortex Moutan 10 ～15 parts, Herba Ecliptae 10～15 parts, Herba Agrimoniae 10～15 parts, the Rhizoma Anemarrhenae 10～15 parts, Rhizoma Drynariae 10～15 parts, the Cortex Eucommiae 10～15 Part, Rhizoma Corydalis 10～15 parts, Caulis Spatholobi 10～15 parts.

In described Chinese medicine composition, external used medicine can also include the crude drug of following parts by weight: Radix Dipsaci 10～20 parts, The Radix Angelicae Dahuricae 10～20 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 10～20 parts, Rhizoma Chuanxiong 10～20 parts, Herba speranskiae tuberculatae 10～20 parts, Radix Notoginseng 10～20 parts, Olibanum 10～15 Part, Myrrha 10～15 parts, Rhizoma Et Radix Notopterygii 10～15 parts, Folium Artemisiae Argyi 10～15 parts, Radix Clematidis 10～15 parts, Radix Saposhnikoviae 10～15 parts.

For solving above-mentioned technical problem, the present invention also provides for a kind of system treating YinXuXueRe type talalgia Chinese medicine composition Preparation Method, its described endo-medicine is that the preparation method of tablet comprises the following steps:

A. the extraction of raw material medicinal alcohol is taken, as component 1；

B. by stripped for ethanol medicinal residues soak by water 2 times, concentrated extracting solution is merged, as component 2；

In described step a, all crude drug can be shredded, be soaked and be placed in lid stainless steel cask, add 70% second Alcohol liquid, quality is coarse grained 0.8-1 times, stirs, moistening airtight placement more than 1 hour, makes fully to expand；By percolator Drug sample after moistening expansion is mixed pine after paving and is done to dissipate by bottom filter plate gauze bag parcel again, then contains with rustless steel spoon Powder, loads percolator uniformly, fills 10-12 cm thick, even by T-bar pressure, then presses aforesaid operations, and loading in layer is suitable Working as pressurization, medicated powder loads 2/3 eminence that must not exceed percolator；Medicated powder face upper cover rustless steel orifice plate fastens, and opens under percolator The baiting valve in face, and put a container, then it is slowly added into 70% ethanol；Air between medicated powder powder to be discharged, and have second Alcohol flows out about about 20L, closes baiting valve, covers cylinder of filtering, dipping 24 hours, then opens baiting valve and carries out percolation, controls percolation Speed is generally 1000g medical material outflow per minute 2～3ml, and filtrate puts into liquid container, and pours ethanol during emptying into storage Fluid cylinder；Being merged by percolate and stand, stand for standby use, as component 1.

In described step b, can above-mentioned stripped raw material residue be put in 10 times amount water, soak 1-2 hour, heating Extracting 2 times, each 1-2 hour, remove supernatant, united extraction liquid, 100-120 mesh filters, then through the molecular weight that dams be 5000- The ultrafiltration post ultrafiltration of 10000, the filtrate of 1.05 when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C, as component 2.

In described step c, can put into 2-in-1 also to component 1 and component in economic benefits and social benefits vacuum concentrator and mix, first by filtrate When being concentrated into 80 DEG C, relative density is the concentrated solution of 1.32, sets to 0～5 DEG C of deepfreezes 24 hours；By helping that cold preservation liquid adds 0.3% Filtering agent kieselguhr, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml extractum Han 0.1g, then add dextrin or Starch tabletting, pack.

For solving above-mentioned technical problem, the present invention also provides for a kind of system treating YinXuXueRe type talalgia Chinese medicine composition Preparation Method, the preparation method of the external preparation spray of described Chinese medicine composition is following steps:

A. take Radix Notoginseng, the Radix Angelicae Dahuricae, the Pseudobulbus Bletillae (Rhizoma Bletillae), the Rhizoma Et Radix Notopterygii way of distillation are vaporized into crystallization, pulverize dusting cover stand-by, as component 1；

B. remaining raw material ethanol is extracted, concentrate, as component 2；

C. after component 1, component 2 being mixed, solubilizer is in harmonious proportion, and sterilization loads aerosol apparatus.

In described step a, first crude drug Radix Notoginseng, the Radix Angelicae Dahuricae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Rhizoma Et Radix Notopterygii and Radix Saposhnikoviae steam method is distilled, tied Brilliant thing, then pulverizes, and crosses 100-120 mesh sieve, standby as component 1.

In described step b, remaining crude drug is shredded, is soaked and be placed in lid stainless steel cask, add 70% ethanol, Quality is coarse grained 0.8-1 times, stirs, moistening airtight placement more than 1 hour, makes fully to expand；Bottom percolator Drug sample after moistening expansion is mixed pine and is done to dissipate by filter plate gauze bag parcel again after paving, then contain powder, all with rustless steel spoon Even loading percolator, fills 10-12 cm thick, even by T-bar pressure, then presses aforesaid operations, and loading in layer suitably adds Pressure, medicated powder loads 2/3 eminence that must not exceed percolator；Medicated powder face upper cover rustless steel orifice plate fastens, and opens below percolator Baiting valve, and put a container, then it is slowly added into 70% ethanol；Air between medicated powder powder to be discharged, and have ethanol stream Go out about about 20L, close baiting valve, cover cylinder of filtering, dipping 24 hours, then open baiting valve and carry out percolation, control percolation speed Generally 1000g medical material outflow per minute 2～3ml, filtrate is put into liquid container, and is poured ethanol during emptying into reservoir Cylinder；Percolate is merged and stands, as component 2；Component 1 is put in component 2, stirs, solubilizer, load aerosol apparatus In, owing to the present invention is without preservative, need cold preservation.

Talalgia is a kind of commonly encountered diseases, is characterized with heel swelling, numb pain, locally tenderness, difficulty in walking.Talalgia Also known as calcanean spur or heel bone hyperosteogeny.Belonging to " rheumatism involving the bone " category in Chinese medicine, pathogenic factor is many strains, outward with old deficiency of the kidney Hinder with to experience cold-damp relevant.YinXuXueRe refers to due to internal cloudy liquid virtual loss, the heating card caused by water failing to restrain blazing fire.Disease sees two flushed cheeks Red, emaciated physique, hectic fever night sweat, dysphoria with feverish sensation in the chest palms and soles, night fever abating at dawn, dryness of the mouth and throat, the few tongue of red tongue, thready and rapid pulse.Control suitable replenishing YIN and removing heat, Or nourishing YIN to lower pathogenic fire.Deficiency of the liver and kindey, blood and essence asthenia, passages through which vital energy circulates loses and fills, then muscle is become homeless foster, and bone is become homeless master, and bone withers flaccidity of tendon and muscle, therefore stands or row When walking heel ache, dull pain, weak, pain pain relieved by pressing, the alleviation of pain touched.Doctor trained in Western medicine typically solves this problem with operation, though there being a constant current modulation Effect, but plant destructive operation, calcaneus posterior tibial nerve is propped up and props up cut-out with sural nerve, have side effect in various degree or cause Some complication；Chinese medicine product then because of its draw materials natural, safety good, low side effect, documents and materials are abundant, clinical efficacy is good And enjoy favor.But existing prescription specific aim is poor, it is impossible to fundamentally alleviate the symptom of talalgia, and the most certain pair Effect.Oral administration and externally amalgamation of the present invention, can effectively expand peripheral vessel, improves foot's microcirculation, blood stasis dispelling of subsiding a swelling, active only Effect bitterly is obvious.Medicine acts on local, permeates skin, through sick institute, promotes qi and blood circulation, improve local blood and run, soft Change bony spur, promote that inflammation absorbs, so that remission or elimination.Therapeutic effect of the present invention is more satisfactory, and non-toxic and safe, preparation Method is simple, can create good social benefit and economic benefit.

Detailed description of the invention

Traditional Chinese Medicine early has research to the disease of talalgia, and Sui Dynasty famous physician Chao Yuanfang (550-630 A.D.) talalgia is called " heel is ruined ", Book cloud: " heel ruined person heel neglect pain, must not also, common customs are exhaled as heel ruined." the big physician Zhu Dan of one of Au element Small stream is referred to as " talalgia " in " danxi's experiential therapy ", it is necessary to use the attached cream in osmanthus.

Plaster is a wonderful work of motherland's medical science, Gu have " reason of the external treatment i.e. reason for the treatment of by oral administration of medicines, the medicine of the external treatment i.e. medicine for the treatment of by oral administration of medicines, Different person, method ear ", " it is sick that plaster can control treatment by Chinese herbs macLean-Maxwell disease, and not different from decoction is done in the proper way with it, its ring vertical should " etc. saying.The Qing Dynasty Famous physician's Xu Ling tire is said: " modern plaster used, the plaster applying a plaster for therapeutic purpose of ancients' meaning..... control inner person, or wind dispelling trembled with fear, or and QI and blood, or Expectorant painful abdominal mass, or strengthening bone and muscle, its side very spirit, medicine is also with disease plus-minus, and its cream preferably weighs thick patch for a long time.”

One, qi stagnation and blood stasis type: a variety of causes cause local blood slowly, stagnation of blood stasis, venation is hindered, then QI-blood circulation is not Freely pain, and localized pain, pain with tenderness, walk limited.

Two, deficiency of the liver and kidney: the other network of Liver and kidney and branch thereof is walked around heel, liver governing tendons, main store blood, and kidney governing bones, main Tibetan The raw marrow of essence, essence.Old body, deficiency of the liver and kindey, blood and essence asthenia, passages through which vital energy circulates loses and fills, then muscle is become homeless foster, and bone is become homeless master, and bone withers flaccidity of tendon and muscle, therefore When standing or walk heel ache, dull pain, weak, pain pain relieved by pressing, the alleviation of pain touched.

Three, cold blood stasis type: QI-blood circulation is slow, feels cold-evil again, cold main stagnates, main spasm, causes meridians to be hindered, QI and blood Stagnate obstructed and pain, pain with tenderness, happiness heat be afraid of cool.

Can make anesthesia needle, effect is fast, and relative costs is cheap.First inject a pin at pain point, see that pain condition can be partly A pin is strengthened after individual month.But anesthesia needle is it cannot be guaranteed that thoroughly solve.Young woman is cautious use of, and is amcinonide, can cause 2-3 Cycle menoxenia, had better not be conceived in half a year." anesthesia needle is by the position of drug injection to pain, reaches antiinflammatory, pain relieving Purpose, and have alleviate local muscular tone effect.Time length can be more than the pipe several years, short several weeks, depending on state of an illness weight, time Between length indefinite.This is a kind of symptomatic treatment measure, and the pain symptom eliminating local is had preferable effect.

Tcm syndrome differentiation and treatment, classification therapy: 1. kidney yin deficiency type: foot shin intermittent fever and talalgia, add Carapax et Plastrum Testudinis, meat with pill of Six Ingredients Osmanthus.2. kidney yang deficiency syndrome: can not standing for a long time and talalgia, with eight taste balls.3. wetness type: weigh and swell, with changing bone pellet, history state public affairs medicine Wine.4. multiple abscess caused by damp-phlegm type: add Fructus Chaenomelis, Bi, Radix Stephaniae Tetrandrae with Daotan Tang.5. QIXUELIANGXU type: with BUZHONG YIQI TANG, medicinal piece of shiquan dabu Soup.6. blood-heat type: add the Rhizoma Anemarrhenae, Cortex Phellodendri, Radix Achyranthis Bidentatae (see " Elementary Medicine tinea pedis ") by SIWU TANG.

Medicine forms: Rhizoma Chuanxiong 20 grams, Radix Aconiti 20 grams, Radix Cyathulae 30 grams, Radix Dipsaci 30 grams, Radix Saposhnikoviae 20 grams, Radix Clematidis 30 grams, wood 20 grams of melon, Herba speranskiae tuberculatae 30 grams, Caulis Spatholobi 30 grams, Rhizoma Corydalis 20 grams, Olibanum 20 grams, Myrrha 20 grams, 50 grams of Natrii Sulfas (separately bag), vinegar 250 milliliters.

Radix Aconiti, Radix Saposhnikoviae, Radix Clematidis, Herba speranskiae tuberculatae, Caulis Spatholobi expelling wind and cold, dredge the meridian passage in side；Rhizoma Corydalis, Rhizoma Chuanxiong, Olibanum, do not have Medicine promoting blood circulation to remove blood stasis, circulation of qi promoting relaxing muscles and tendons；Fructus Chaenomelis, Radix Dipsaci, Radix Cyathulae invigorating the liver and kidney, bone and muscle strengthening；Natrii Sulfas hard masses softening and resolving, reducing swelling and alleviating pain；Vinegar Containing vinegar ion, there is stronger osmosis, blood circulation promoting and blood stasis dispelling can be helped, the power of hard masses softening and resolving.Fumigation and wash method decocted by all liquid medicine, and medicine acts on office Portion, permeates skin, through sick institute, promotes qi and blood circulation, improve local blood and run, soften bony spur, promote that inflammation absorbs, thus Make remission or elimination.

Usage: front 12 taste medicines are added 3000 milliliters of cold water, soaks 12 hours, boils 30～40 minutes, pour in basin, add awns Nitre, vinegar stir evenly.First fumigate affected part with steam, when water temperature is not scalded, embathe trouble foot.Can reheat during water temperature drop, each fumigation and wash method Time be no less than 1 hour, the most each 1 time.1 dose of medicine can be with two days.

Traditional Chinese medical science QI and blood theory is thought, qi-blood circulating process is the material base that all histoorgans of human body are operated, gas Blood is with smoothness balance for expensive, if QI and blood is the most smooth will produce blood stasis, blood stasis hinders in internal, will further result in qi-blood circulating Deterioration, cause more serious stasis of blood plug, therefore the traditional Chinese medical science be with QI and blood as guiding principle, be allowed to smooth balance by regulating qi and activating blood, can disease-relieving and physique enhancing, Unsting and invigorate blood circulation.

The Radix Paeoniae Alba enters liver, spleen channel, nourishing blood to suppress the hyperactive liver, and slow middle pain relieving, yin fluid astringing receives antiperspirant.Controlling the chest and abdomen pain over the hypochondriac region, dysentery is suffered from abdominal pain, spontaneous perspiration Night sweat, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia, married woman's blood closes obstructed, repercussive blood, can lose pus, benefit woman's blood." solar corona Book on Chinese herbal medicine ": control wind, mend labor, all diseases of main woman, and antenatal rear all diseases, Tong Yueshui, bring down a fever, relieving restlessness, QI invigorating, the hot disease of sky row, pestilence Miasma, mania and irritation, married woman's blood is transported, and hemorrhoidal hamorrhage, rushes down blood, hemorrhoid complicated by anal fistula.Carbuncle on the back, skin ulcer scabies, headache, improving eyesight, conjunctival congestion exerts meat.The many QI invigorating of redness of the skin or complexion person, White person controls blood.

The Rhizoma Anemarrhenae, Classification system: Anemarrhena asphodeloides Bunge, also it is RHIZOMA ANEMARRHENAE with peet, perennial herb is planted The dry root stock of thing this kind is famous Chinese medicine, property bitter cold, has nourishing YIN to lower pathogenic fire, moisturizes laxation, the effect of profit defecation.Belong to heat clearing away reducing internal heat Medicine, cures mainly: epidemic febrile disease, high hot excessive thirst, cough and asthma, cough caused by dryness, constipation, osteopyrexia and fever, restlessness of asrhenia type and insomnia, stranguria with turbid discharge of quenching one's thirst.Have that " hair is known Female " with " unpeeled RHIZOMA ANEMARRHENAE " point.Main producing region is in Hebei.Chinese medicine is called: rabbit Herba Leptochloae Chinensis, great Lu water, Ma Macao, garlic clove grass, Furuncle root, L.Lucidus Turcz. etc..

Radix Ophiopogonis, " book on Chinese herbal medicine lease making " claims that Radix Ophiopogonis, " hardship sweet, micro-, was slightly cold.Lung moistening clears away heart-fire, purge heat and promote the production of body fluid, the preventing or arresting vomiting that reduces phlegm, control row of coughing Water "." Records of Tradition Chinese and Western Medicine in Combination " says it: " can enter stomach with nourishing the stomach liquid, stimulating appetite, more can enter spleen helping spleen to dissipate and be skillful in lung, Dingchuan Relieving coughing." traditional Chinese medical science thinks, Radix Ophiopogonis sweet in the mouth, micro-hardship, cold nature, return stomach, lung, heart channel, have nourishing YIN and moistening the lung, reinforcing stomach reg fluid, clear away heart-fire relieving restlessness Effect, cough for dryness of the lung dry cough, deficiency of YIN consumptive disease, sore throat pharyngalgia, Tianjin wound are thirsty, interior-heat is quenched one's thirst, vexed insomnia, dryness of the intestine constipation etc. Disease.Modern pharmacological research also indicates that, Radix Ophiopogonis is mainly containing dwarf lilyturf glycosides, steroidal saponin, alkaloid, sitosterol, glucose, amino Acid, vitamin etc., have resisting fatigue, remove free radical, raising cellular immune function and hypoglycemic effect.It addition, Radix Ophiopogonis Have calmness, hypnosis, resist myocardial ischemia, the effect such as arrhythmia, antitumor, especially there is many-side to promoting senior health and fitness Effect.

The Cortex Eucommiae, the medicinal Cortex Eucommiae, it is the dry bark of the Eucommiaceae plant Cortex Eucommiae, is Chinese famous and precious tonic herb.Its sweet in the mouth, Warm in nature.There are liver and kidney tonifying, bone and muscle strengthening, Chong and Ren Meridians regulating, consolidate through antiabortive effect.Lumbago and skelalgia or acid that insufficiency of kidney-YANG causes can be treated Soft unable, the diseases such as born of the same parents' tire that deficiency of liver-QI causes is not solid, scrotum pruritus due to damp pathogen.Shennong's Herbal is listed in top grade.The Cortex Eucommiae is dissociated Aminoacid is few, a small amount of protein contained, be with most foodstuffs as adequate proteins, i.e. can hydrolyze detection to people 8 kinds of aminoacid that body is required.Determine 15 kinds of mineral elements contained by the Cortex Eucommiae, wherein have trace element such as zinc, copper, ferrum, and calcium, The macroelements such as phosphorus, potassium, magnesium.The modern study Cortex Eucommiae has rubbish in purged body, strengthens human body cell substance metabolism, prevents muscle Skeleton is aging, balanced human's blood pressure, decomposer inner cholesterol, reduces body fat, recovers blood vessel elasticity, diuresis heat clearing away, wide spectrum Antibacterial, stimulating central nervous system, improves leukocyte pharmacological action.

Herba Agrimoniae source is the aerial parts of rosaceous plant Agrimony Agrimonia pilosa Ledeb..Bitter, cool. Return stomach, liver, spleen, lung, large intestine channel.Drug effect: anticancer, the cooling blood for hemostasis of relieving internal heat, detumescent of healing the wounds.Containing agrimophol (agrimophol), Agrimonolide (agrimonolide), and containing galuteolin (luteoloside), Herba Agrimoniae first, second, C prime (agrimonin A, B, C), match agrimophol A～E (agrimol A～E), separately containing tannin, sterol, Saponin and volatile oil.Nature and flavor are put down, bitter in the mouth, Puckery.

Rhizoma Corydalis, (Corydalis yanhusuo W.T.Wang ex Z.Y.Su et C.Y.Wu), have another name called: Rhizoma Corydalis, profound Rhizoma Corydalis, rhizoma corydalis, Rhizoma Corydalis etc..Being Papaveraceae, Corydalis herbaceos perennial, tuber is spherical, petal aubergine；Capsule cylinder Shape, two ends are the narrowest.Summer-flowering.Tuber is famous conventional Chinese medicine, containing more than 20 kinds of alkaloids, for promoting the circulation of QI to relieve pain, Huoxue San " The stasis of blood, traumatic injury etc..Cure mainly: invigorate blood circulation；Dissipating blood stasis；Regulate the flow of vital energy；Pain relieving.Main trusted subordinate's all pains of waist knee joint；Menoxenia；Lump in the abdomen；Metrorrhagia；Puerperal Bruise；Lochiorrhea；Traumatic injury." medicine origin ": control that taste are depressed stagnant not to be dissipated, main asthenia cold diarrhea, cardiac and abdominal pain, the therapeutic method to keep the adverse QI flowing downwards disappears Food." detailed outline ": invigorate blood circulation, promoting the circulation of QI, pain relieving, diuresis.Rhizoma Corydalis, the stagnation of QI in energy promoting the circulation of blood, stasis in gas, therefore specially control the most all Bitterly, among use, simply fantastic.

Radix Rehmanniae Preparata is the tuber of scrophulariaceae rehmannia glutinosa plant (formal name used at school: Rehmannia glutinosa), has another name called Radix Rehmanniae Preparata or volt Ground, the processed process of preparing Chinese medicine forms.Generally with wine, Fructus Amomi, Pericarpium Citri Reticulatae for adjuvant through repeatedly steaming solarization, glossy to inside and outside darkish complexion, quality is soft Sticky.Section use, or parch to black use.Radix Rehmanniae Preparata has another name called Radix Rehmanniae Preparata or throws oneself on the ground, and belongs to goatweed, is a kind of first-class Chinese crude drug, has YIN nourishing of enriching blood effect, can be used for blood deficiency and yellow complexion, dizziness, palpitation and insomnia, menoxenia, the disease such as metrorrhagia, also can be used for deficiency of kidney yin Hectic fever hectic fever due to YIN-deficiency, night sweat, pass out semen, the disease such as quench one's thirst, be one of deficiency syndrome class nonprescription drugs medicine LIUWEI DIHUANG WAN main component.

Rhizoma Drynariae is bitter, temperature.Enter liver, kidney channel.Function cures mainly the kidney invigorating, invigorates blood circulation, hemostasis.Control suffer from a deficiency of the kidney chronic diarrhea and lumbago, rheumatism numbness Bitterly, toothache, tinnitus, traumatic injury sprain and contusion, bone injury, appendicitis, alopecia areata, clavus." property of medicine opinion ": " poison in main bone, wind blood pain, five Labor six types of severe debility disease, mouth (one make ' foot ') hands do not receives, upper heat and lower cold." " Japan hanako materia medica ": " controls malignant boil, loses rotten meat, parasite killing.″

Pseudobulbus Bletillae (Rhizoma Bletillae) property is bitter, sweet, puckery, is slightly cold.Return lung, liver, stomach warp.Function cures mainly astringing to arrest bleeding, detumescence and promoting granulation.Tell for hemoptysis Blood, traumatic hemorrhage, sore swollen toxin, chapped skin；Pulmonary tuberculosis hemoptysis, ulcer haemorrhage.Shennong's Herbal: " main carbuncle, evil Skin ulcer, lose cellulitis, the dead flesh of impairment of YIN, pathogen in stomach "；Compendium of Material Medica: " abnormal smells from the patient (root) is bitter, flat, nontoxic.

Radix Angelicae Dahuricae meridian distribution of property and flavor: pungent, temperature.Attach to the lung and stomach meridians.Expelling wind and cold, sensible pain relieving, detumescence and apocenosis, dampness leukorrhagia stopping." day China's son book on Chinese herbal medicine ": control conjunctival congestion bulbar conjunctiva polyp, and tire patching leakage landing, broken stagnated blood, mend fresh blood, acute mastitis, carbuncle on the back, scrofula, hemorrhoidal hamorrhage, hemorrhoid complicated by anal fistula, row Pus, desolation, scabies, pain relieving granulation promoting, go face defect scar.

Radix Salviae Miltiorrhizae is bitter, is slightly cold.GUIXIN, Liver Channel.Stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, clear away heart-fire relieving restlessness.For menoxenia, amenorrhea pain Warp, lump in the abdomen, chest and abdomen twinge, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia.For costa sternales hypochondriac pain, rheumatic arthralgia, lump in the abdomen is tied Block, skin infection swells and ache, and tumbling down is grieved, menoxenia, amenorrhea dysmenorrhea, puerperal stasis of blood pain etc..Treatment costa sternales pain, lump in the abdomen caking, and Menoxenia, amenorrhea dysmenorrhoea have good effect." detailed outline " carries: Radix Salviae Miltiorrhizae, and by " the sensible opinion of married woman " cloud, SIWU TANG is controlled gynecopathy, paid no attention to Antenatal puerperal, how many through water, the most generally applicable, only taste Radix Salviae Miltiorrhizae dissipates, and cures mainly same.Lid Radix Salviae Miltiorrhizae can break stagnated blood, mends fresh blood, peace Green tire, fall stillborn fetus, only metrorrhagia dysentery, regulating menstruation arteries and veins.Main Compositions of Radix Salviae Miltiorrhizae TANSHINONES has expansion blood vessel, improves circulation, releasing blood vessel Intravascular coagulations etc. act on, and have effect of invigorating blood circulation trace, and can promote that liver blood circulates, beneficially liver cell regeneration.

Flos Carthami (Classification system: Carthamus tinctorius L.), another name: red blue flower, thorn Flos Carthami, Compositae, Flos Carthami belong to Plant, dry tubular flower, orange red, floral tube is narrow carefully, and tip 5 splits, and sliver is narrow linear, and flower pesticide yellow is unified into pipe, exceeds and split Outside sheet, its central authorities have stigma to expose.Have special fragrance, mildly bitter flavor.To spend, length of a film, color be scarlet, the soft person of matter is preferred.Invigorate blood circulation logical Warp, eliminating stasis to stop pain, contribute to controlling amenorrhea, dysmenorrhea, lochia, obstruction of qi in the chest and cardialgia, the stagnant stomachache of the stasis of blood, the breast side of body twinge, traumatic injury, skin ulcer Infections swells and ache curative effect.Blood circulation promoting and blood stasis dispelling, wet dissipation is had to go the effect swollen.

Cortex Phellodendri bitter in the mouth, cold in nature.Return kidney, bladder warp.Function has heat clearing and damp drying, and pathogenic fire purging is except steaming, effect of detoxification sore treatment.Cure mainly For damp-heat dysentery, jaundice dark coloured urine, leukorrhagia pudendal pruritus, the puckery pain of pyretic stranguria, tinea pedis flaccidity is preesed, hectic fever due to YIN-deficiency consumptive fever, night sweat, seminal emission, sore swollen toxin, Eczema eczema.Stir-baked CORTEX PHELLODENDRI with salt solution nourishing YIN to lower pathogenic fire.For hyperactivity of fire caused by deficiency of YIN, night sweat hectic fever due to YIN-deficiency." clinical conventional Chinese medicine handbook ": Cortex Phellodendri bitter cold is sunk Fall, heat clearing and damp drying, eliminating fire and detoxication power is strong, returns kidney, bladder warp, is longer than clear damp-heat in lower-JIAO.

Radix Notoginseng is to be used as medicine with its root, and it is warm in nature, acrid in the mouth, has significant blood circulation promoting and blood stasis dispelling, subduing swelling and relieving pain effect, has " gold Do not change ", the good reputation of " southern part of the country SHENCAO ".Because season in Chang Chun winter two excavates, it is divided into again " spring seven " and " winter seven ".Qing Dynasty's pharmaceutical texts Described in supplementary Amplifications of the Compendium of Materia Medica: " ginseng qi-tonifying first, Radix Notoginseng enriches blood first, taste with and merit also etc., therefore claim Panax pseudoginseng, for Most precious person in Chinese medicine." become famous Chinese patent medicine " YUNNAN BAIYAO " at home and abroad and " Pien Tze Huang ", i.e. with Radix Notoginseng for primary raw material system Become.Cure mainly spitting of blood, spit blood, epistaxis, have blood in stool, metrorrhagia, traumatic hemorrhage, chest and abdomen twinge, tumbling and swelling.

Rhizoma Et Radix Notopterygii, another name Qiang is blue or green, protect Qiang envoy, recklessly king envoy, Qiang is sliding, move back wind envoy, black powder, Latin literary fame Notopterygium incisum. Umbelliferae, Notopterygium plant, Chinese medicine cures mainly: warm in nature, dispelling cold and dampness, for affection of exogenous wind-cold, head The most lossless, cold-damp numbness, upper limb rheumatalgia.Dissipate exterior cold；Wind-damp dispelling；Profit joint；Pain relieving.Main affection of exogenous wind-cold；Have a headache lossless；Edema due to wind pathogen Edema；Sore swollen toxin.For impotence and seminal emission, enuresis frequent micturition, chills and pain of the waist and kness, suffer from a deficiency of the kidney and breathe heavily, Diarrhoea；External curing vitiligo, Alopecia areata.Relieving exterior syndrome and dispelling cold, expelling wind and dampness, pain relieving.Property of medicine opinion ": " controlling harmful wind, aphonia in silence, blood leprosy of itching, hands and feet caused by paralysis, actinal surface is askew more Heresy, insensitive impediment all over." " Japan hanako materia medica ": " controls a wind cutting gas, muscles and bones fist contraction, and extremity are won bad, the head rotation red pain of eyes and fullness in the epigastrium especially referring to the abcess of the abdomen in ancient times Aqueous vapor, five kinds of strain and seven kinds of impairment, deficient cold air, joint ache, tonneau the five internal organs.″

Rhizoma Chuanxiong, formal name used at school: Ligusticum chuanxiong hort, cultivated plant, main product is in Sichuan (Guanxian county), at cloud The ground such as south, Guizhou, Guangxi, are grown on the climatic environment of gentleness.It is a kind of Chinese medicinal plant, is usually used in blood-activating and qi-promoting, wind-expelling pain-stopping, The pungent temperature of Rhizoma Chuanxiong is fragrant dry, walks and does not keeps, can go scattered, up up to top, mountain peak；Enter again blood system, descending up to the sea of blood.Blood circulation promoting and blood stasis dispelling is made With extensively, the various disease of suitable stagnation of blood stasis；Wind-expelling pain-stopping, effectiveness is favourable, can control the diseases such as wind syndrome of head headache, rheumatic arthralgia.Former times people Meaning Rhizoma Chuanxiong is the gas medicine in blood, the function such as its residence of dangerous speech is pungent to be dissipated, resolving depression, sensible, pain relieving.

Radix Achyranthis Bidentatae medical value root is used as medicine, raw use, promoting blood circulation to restore menstrual flow；Control puerperal abdonimal pain, menoxenia, amenorrhea, epistaxis, asthenic fire tooth Bitterly, tinea pedis edema；Ripe use, invigorating the liver and kidney, strong waist knee joint；Control soreness of waist and knee joint, caused by liver and kidney deficiency, traumatic injury stasis of blood pain.Veterinary is used as to control cattle weak foot Disease, gets injured by a fall knochenbruch etc..Medicinal part: the dry root of plant.Nature and flavor: bitter, sweet, sour are flat.Gui Jing: return liver, kidney channel.Effect: removing blood stasis Stimulate the menstrual flow, invigorating the liver and kidney, bone and muscle strengthening, inducing diuresis for treating stranguria syndrome, conducting blood to flow downwards.Cure mainly: for amenorrhea, dysmenorrhea, soreness of waist and knee joint, muscles and bones is unable, drench Card, edema, headache, dizziness, toothache, day skin ulcer, spit blood, epistaxis.

Folium Artemisiae Argyi is pungent, bitter, temperature.Gui Jing returns liver,spleen,kidney warp.Effect warming the meridian for stopping bleeding, dispersing cold for relieving pain；External removing dampness to relieve itching.Cure mainly For spitting blood, epistaxis, metrorrhagia, menorrhagia, vaginal bleeding during pregnancy hematochezia, few abdomen cold type of pain, coldness and unbalance in meridians, cold womb is infertile；External treatment skin pruritus. Vinegar Chinese mugwort charcoal warming the meridian for stopping bleeding is hemorrhage for deficient cold type.Compendium of Material Medica: warming middle-JIAO, by cold, dehumidifying." book on Chinese herbal medicine is looked for the truth ": specially enter liver spleen. Double enter kidney." Bencao Congxin ": by cold-damp.Warm uterus.Only all blood.Warming middle-JIAO dissipating depression of QI.Regulating menstruation is antiabortive.

Chinese medicine Radix Polygoni Multiflori have Radix Polygoni Multiflori and Radix Polygoni Multiflori Preparata point, direct slicing is used as medicine for Radix Polygoni Multiflori, after mixing steaming with Semen sojae atricolor liquor Dry and be used as medicine for Radix Polygoni Multiflori Preparata.The function of the two is different: the removing toxic substances of Radix Polygoni Multiflori function, eliminating carbuncle, loosening bowel to relieve constipation, is usually used in treating scrofula Scrofula carbuncle sore, rubella pruritus, dryness of the intestine constipation；Radix Polygoni Multiflori Preparata function invigorating the liver and kidney, benefiting essence-blood, crow beard and hair, bone and muscle strengthening, for blood deficiency and yellow complexion, Vertigo and tinnitus, early whitening of beard and hair, soreness of the waist and knees, numb limbs and tense tendons, bleeding not during menses, chronic malaria body are empty.Radix Polygoni Multiflori Preparata of the present invention It it is the good merchantable brand of invigrating kidney.

Fructus Lycii: sweet, flat.Folium Lycii: bitter, sweet；Cool in nature.Function: Fructus Lycii: nourishing the liver, nourishing kidney, lung moistening.Folium Lycii: qi-restoratives benefit Essence, clearing away heat to improve acuity of vision.Lycium barbarum polysaccharide is a kind of water soluble polysaccharide, is topmost active component in Fructus Lycii, and relative molecular mass is 68-200, becomes domestic and international study hotspot.The most again with immunomodulating and the most study of antitumor action of lycium barbarum polysaccharide.Existing Existing a lot of research show lycium barbarum polysaccharide have promotion immunity, defying age, antitumor, removing free radical, resisting fatigue, radioprotective, Protect the liver, reproductive function protection and the effect such as improvement.

Cortex Lycii, another name: Chinese wolfberry skin, for Solanaceae, Lycium, is the root of Fructus Lycii Lycium chinense Mill. Skin.Can be used as medicine, have and bring down a fever except the effect of steaming, removing heat from blood is except effects such as steaming, lung heat clearing pathogenic fire reducing.

Herba Ecliptae grass is the conventional liver-nourishing kidney-boosting of the traditional Chinese medical science, cooling blood for hemostasis medicine.To the Light-headedness caused by the hepatic and renal YIN deficiency, tooth Loose compact, aching pain in waist and back, all diseases of flaccidity and weakness of the lower limbs and caused by heat in blood multiple go out blood disorder have good efficacy.Herba Ecliptae contains volatilization The chemical compositions such as oil, tannin, Saponin, Herba Ecliptae element and vitamin A.Animal experiment has haemostatic effect, and in vitro tests is to golden yellow Staphylococcus has inhibitory action.

Cortex Moutan, has another name called Cortex Moutan, Chinese medicine name.It is dried root bark for ranunculaceae peony.Originate in the ground such as Anhui, Shandong.Autumn Excavate root season, remove radicula, strip root bark, dry.Life is used or is fried and uses.Compendium of Material Medica: " nourishing YIN to lower pathogenic fire solves speckle poison, sore-throat relieving Larynx, diuresis stasis.Descendant is specially to control fire mutually with yellow tiller, does not knows that the merit of Cortex Moutan more wins also.Red colored person profit, the person of spending in vain mends, and people is also Seldom realize, preferably distinguish it." modern study, contained paeonol and glucosides constituents in addition thereof all have antiinflammatory action；The first of Cortex Moutan Alcohol extraction thing has suppression Platelet；Paeonol has central inhibitory actions such as calmness, cooling, antipyretic, analgesia, spasmolytic and anti-dynamic Pulse atherosclerosis, diuresis, antiulcer etc. act on.

Caulis Spatholobi, for the another name of the various plants such as Schisandraceae, Sargentodoxaceae, Cuscutaceae, Papilionaceae.[1] 8～9 The moon gathers, and is distributed in China East China, South China and the ground such as Hubei, Yunnan.Caulis Spatholobi bitter but slightly sweet taste, warm in nature, return liver, the heart, kidney Warp, red complexion enters blood, and matter profit row dissipates；There is relaxing muscles and tendons to promote blood circulation, effect of nourishing blood for regulating menstruation；Cure mainly rheumatic arthralgia, numb hand and foot, limbs paralysis Paralysis, menoxenia, blockage of menstruation, dysmenorrhea, amenorrhea, leukopenia.Treat the waist gonalgia caused by rheumatism, rheumatism numbness Bitterly, numb limbs and tense tendons, often and the compatibility such as Flos Carthami Semen Persicae, Radix Paeoniae Rubra, Pheretima, the Radix Astragali, Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae.Can be used for menoxenia, amenorrhea, Dysmenorrhea, normal and Rhizoma Cyperi, the same use of Herba Leonuri.

Radix Dipsaci, has another name called Radix Dipsaci, also name Radix Dipsaci, Chinese medicine name.For the root of herbaceos perennial Radix Dipsaci, because of energy, " continuous folding connects Bone " and gain the name.Autumn excavates, and removes root head and fibrous root, is dried to low baking temperature half-dried, when bank up " diaphoresis " is to internal virescence, then Dry." the southern regions of the Yunnan Province book on Chinese herbal medicine ": " meridians are determined in tonifying liver, bone and muscle strengthening, and only in warp, (muscles and bones) is ached, antiabortive, is suitable for controlling married woman leucorrhea, Tissue regeneration promoting blood, removing blood stasis with potent drugs blood, fall stillborn fetus, and cough-relieving is coughed hemoptysis, controls red white turbid urine.”

Herba speranskiae tuberculatae, (formal name used at school: Phryma leptostachya L.subsp.asiatica (Hara) Kitamura) is used as medicine Part is plant herb.Green, dry with herb color, matter is tender, free from admixture person is preferred.It is distributed in all parts of the country.It mostly is artificial plantation. Reddish brown with stem color, without leaf, be dried, free from admixture person is preferred.Annual herb flowers, produce the nations of China and India.Property happiness sunlight, be afraid of Wet, heat-resisting can not resist cold, suitable be born in loose fertile micro-sour soil earth, but the most barren-resistant.Adaptability is relatively strong, transplants and easily survives, growth Rapidly.Seed also name Semen Impatientis, stem also name Herba speranskiae tuberculatae, all can be used as medicine, have blood circulation promoting and blood stasis dispelling, diuresis removing toxic substances, deep effect of stimulating the menstrual flow. External application mashed by fresh grass, can control the swollen pain of furuncle, insect-bite.

Olibanum, Chinese medicine name.For olive subject plant Boswellia carterii Boswellia carterii Birdw. and congener The resin that Boswellia bhaurdajiana Birdw. bark oozes out.It is divided into Somalia's Olibanum and Gum Olibanum Ethiopia, often Planting Olibanum man's cap used in ancient times again is Olibanum pearl and former Olibanum.Blood-activating and qi-promoting pain relieving, detumescence and promoting granulation.Cure mainly for obstruction of qi in the chest and cardialgia, gastralgia, bitterly Through amenorrhea, postpartum stagnation, lump in the abdomen stomachache, rheumatic arthralgia, muscle arteries and veins contracture, traumatic injury, carbuncle skin infection.

Myrrha, Chinese medicine name.For olive subject plant Herba Violae tree Commiphora myrrha Engl. or Ha Didingshu The dry resin of Commiphora molmol Engl..It is divided into natural Myrrha and gum opoponax.It is distributed in Somalia, Ethiopia Russia Than Asia and south, the Arabia Peninsula and other places.There is dissipating blood stasis analgesic therapy, effect of detumescence and promoting granulation.It is usually used in obstruction of qi in the chest and cardialgia, gastralgia, Dysmenorrhea amenorrhea, postpartum stagnation, abdominal mass stomachache, rheumatic arthralgia, traumatic injury, the treatment of the diseases such as carbuncle skin infection.

Radix Clematidis belongs to medicinal plants, and medical material Ji Yuan source is more, " Kaibao Bencao ", " Bencao Tujing ", herbal for Relief of Famines Etc. contained Radix Clematidis, for goatweed；The Radix Clematidis that " the southern regions of the Yunnan Province book on Chinese herbal medicine " is contained, is feverfew, and uses many now For " China's book on Chinese herbal medicine " contained cohosh Radix Clematidis, Clematis hexapetala, northeast clematis.Domestic distributed more widely, its root and stem It is used as medicine and there is wind-damp dispelling, the meridian dredging, the effect of the bone stalk that disappears.In modern clinic is put into practice, its new purposes is constantly found, as Treatment cholelithiasis, calcanean spur, talalgia, the esophageal carcinoma etc..Expelling wind and removing dampness, removing obstruction in the collateral to relieve pain, expectorant water, dissipate the hypochondriac lump.Cure mainly gout Insensitive impediment, rheumatic arthralgia, numb limbs and tense tendons, knee joint cold type of pain, muscle arteries and veins contracture, joint stuffiness, tinea pedis, malaria, lump in the abdomen, tetanus, flat Fructus Persicae body is scorching, and all a fishbone or other bone caught in the throat swallow.Tang Materia Medica: waist, kidney, foot knee joint, accumulation, all cold diseases of enteral, is not recovered, the effect of clothes." Kai Baoben Grass ": main all wind, logical five Tibetan of a surname, cold stagnant in removing abdomen, septum cordis expectorant water amasss for a long time, and lump in the abdomen Xuan tinea air parcel, bladder place pus aversion to water, waist knee joint is cold Pain and treatment injured.

Radix Saposhnikoviae, Chinese medicine name.Another name copper rue, Hui Yun, return grass, Rhizoma Cibotii, hundred kinds.It is the name of a kind of medicinal herbs, perennial herb Plant, its nice and cool weather of happiness, cold-resistant, drought-resistant, main product in Hebei, Heilungkiang, Sichuan, the ground such as Inner Mongol.The Gen Kesheng of Radix Saposhnikoviae With.Acrid in the mouth, sweet, slightly warm in nature.There are expelling pathogenic wind from the body surface, removing dampness to relieve pain, effect of relieving convulsion.

Specific embodiment 1

The preparation of oral pills of the present invention:

By Radix Paeoniae Alba 1000g, Cortex Lycii 1000g, Radix Ophiopogonis 1000g, Radix Rehmanniae Preparata 1000g, Cortex Phellodendri 1000g, Radix Polygoni Multiflori Preparata 1000g, cattle Knee joint 1000g, Flos Carthami 1000g, Fructus Lycii 1000g, Cortex Moutan 1000g, Herba Ecliptae 1000g, Herba Agrimoniae 1000g, Rhizoma Anemarrhenae 1000g, osteomiosis Mend 1000g, Cortex Eucommiae 1000g, Rhizoma Corydalis 1000g, Caulis Spatholobi 1000g, add soak with ethanol 2-3 hour accounting for its quality 7-10 times, Heating extraction 2 times, each 1-2 hour, united extraction liquid, remove supernatant after standing, then 100-120 mesh filters, then through damming Molecular weight is the ultrafiltration post ultrafiltration of 5000-10000, the filtrate of 1.25 when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C.Again will The medicinal residues of the crude drug that above-mentioned ethanol extraction is crossed add 10 times amount water, heating and refluxing extraction 2 times, each 1～2 hour, extract 2 times Liquid merges standing, the filtrate of 1.25 when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C, mixes two kinds of extraction filtrates and inserts economic benefits and social benefits In vacuum concentrator, when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.05, sets to 0～5 DEG C of deepfreezes 24 hours；By cold preservation The filter aid kieselguhr that liquid adds 0.3%, filters, and filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml crude drug Han 0.1g Amount, then adds Mel and is twisted into pill.

Specific embodiment 2

The present invention takes granule orally:

By Radix Paeoniae Alba 1200g, Cortex Lycii 1300g, Radix Ophiopogonis 1100g, Radix Rehmanniae Preparata 1200g, Cortex Phellodendri 1300g, Radix Polygoni Multiflori Preparata 1100g, cattle Knee joint 1200g, Flos Carthami 1100g, Fructus Lycii 1200g, Cortex Moutan 1300g, Herba Ecliptae 1200g, Herba Agrimoniae 1200g, Rhizoma Anemarrhenae 1100g, osteomiosis Mending 1200g, Cortex Eucommiae 1100g, Rhizoma Corydalis 1200g, Caulis Spatholobi 1200g, chopping is soaked to be placed in lid stainless steel cask, adds 70% ethanol, quality is coarse grained 0.8-1 times, stirs, moistening airtight placement more than 1 hour, makes fully to expand；Will Bottom percolator filter plate gauze bag parcel pave after again the drug sample after moistening expansion is mixed pine do dissipate, then use rustless steel Powder contained by spoon, loads percolator uniformly, fills 10-12 cm thick, even by T-bar pressure, then presses aforesaid operations, dress in layer Entering, suitably pressurize, medicated powder loads 2/5 eminence that must not exceed percolator；Medicated powder face upper cover rustless steel orifice plate fastens, and opens percolation Cylinder baiting valve below, and put a container, then it is slowly added into 70% ethanol；Air between medicated powder powder to be discharged, and There is ethanol to flow out about about 20L, close baiting valve, cover cylinder of filtering, dipping 24 hours, then open baiting valve and carry out percolation, control Percolation speed is generally 1000g medical material outflow per minute 2～3ml, and filtrate puts into liquid container, and is fallen by ethanol during emptying Enter liquid container；Percolate is merged and stands, stand for standby use；The filtrate of filtration is inserted in economic benefits and social benefits vacuum concentrator, is concentrated into 90 DEG C time relative density be the concentrated solution of 1.05, set to 0～5 DEG C of deepfreezes 24 hours；The filter aid diatom that cold preservation liquid is added 0.3% Soil, filters, and filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml crude drug amount Han 0.1g, adds dextrin or starch is made Grain.

Specific embodiment 3

The preparation method of external spraying agent:

Radix Notoginseng 1000g, Radix Angelicae Dahuricae 1000g, Pseudobulbus Bletillae (Rhizoma Bletillae) 1000g, the Rhizoma Et Radix Notopterygii 1000g way of distillation are vaporized into crystallization, pulverize stand-by, For component 1；Other raw materials Radix Dipsaci 1000g, Rhizoma Chuanxiong 1000g, Herba speranskiae tuberculatae 1000g, Olibanum 1000g, Myrrha 1000g, Folium Artemisiae Argyi 1000g, Radix Clematidis 1000g, Radix Saposhnikoviae 1000g soak with ethanol, heated and boiled 3 times, each 1-2 hour, to filter, filtrate is standby； By in the filtrate suction concentrating under reduced pressure tank merging latter 3 times, being evaporated to relative density is 1.20, temperature to 60 DEG C-70 DEG C Extractum；Become component 2, blending ingredients 1 and component 2, mediation substrate, load in aerosol apparatus.

Specific embodiment 4

Preparation method by externally used paste of the present invention:

According to described number by raw material Radix Dipsaci 1200g, Rhizoma Chuanxiong 1200g, Herba speranskiae tuberculatae 1200g, Olibanum 1200g, Myrrha 1200g, Folium Artemisiae Argyi 1200g, Radix Clematidis 1200g, Radix Saposhnikoviae 1200g.Add in the Oleum Sesami of 5-10 times of weight portion and soak 7-10 days；By fiber crops The soaked crude drug heating extraction of oil, big fire boils, and after Oleum Sesami boiling, firepower reduces, endure to crude drug appearance be dark brown, Internal coke yellow, pulls medicinal residues out, continues to temper by medicine oil, and be stirred continuously, and refining is to beading of dripping.By Radix Notoginseng 1500g, the Radix Angelicae Dahuricae 1500g and Pseudobulbus Bletillae (Rhizoma Bletillae) 1500g, the Rhizoma Et Radix Notopterygii 1500g way of distillation is distilled into crystallization, and is ground into mistake 200-300 mesh sieve after fine powder.To sieve Crystallization fine powder put in the medicine oil tempered, paste making agent is poured in cold water the most afterwards, soaks 5-10 days, changes water every day once, go Fire-toxin, adds appropriate vaseline paste making agent.The ointment that can also obtain in aforementioned manners soaks gauze, makes gauze agent, every night or Free time encases at sufferer, slowly massages-1 hour half an hour.

Specific embodiment 5

The preparation method of the liniment of external is

Radix Notoginseng 1200g, Radix Angelicae Dahuricae 1300g, Pseudobulbus Bletillae (Rhizoma Bletillae) 1200g, the Rhizoma Et Radix Notopterygii 1200g way of distillation are vaporized into crystallization, pulverize stand-by, For component 1；Other raw materials Radix Dipsaci 1200g, Rhizoma Chuanxiong 1200g, Herba speranskiae tuberculatae 1200g, Olibanum 1200g, Myrrha 1200g, Folium Artemisiae Argyi 1200g, Radix Clematidis 1200g, Radix Saposhnikoviae 1200g, soaked and be placed in lid stainless steel cask, adds 70% ethanol, and quality is thick 0.8-1 times of granule, stirs, moistening airtight placement more than 1 hour, makes fully to expand；By filter plate yarn bottom percolator Drug sample after moistening expansion is mixed pine and is done to dissipate by cloth bag parcel again after paving, then contain powder with rustless steel spoon, load uniformly Percolator, fills 10-12 cm thick, even by T-bar pressure, then presses aforesaid operations, and loading in layer is suitably pressurizeed, and medicated powder is filled out Dress must not exceed 2/3 eminence of percolator；Medicated powder face upper cover rustless steel orifice plate fastens, and opens the baiting valve below percolator, and Put a container, be then slowly added into 70% ethanol；Air between medicated powder powder to be discharged, and there have ethanol to flow out about 20L to be left The right side, closes baiting valve, covers cylinder of filtering, dipping 24 hours, then opens baiting valve and carries out percolation, controls percolation speed generally 1000g medical material outflow per minute 2～3ml, filtrate is put into liquid container, and is poured ethanol during emptying into liquid container；To ooze Filtrate merges standing, stand for standby use；The filtrate of filtration being inserted in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C, relative density is The concentrated solution of 1.05, sets to 0～5 DEG C of deepfreezes 24 hours；The filter aid kieselguhr adding 0.3% by cold preservation liquid, filters, and filtrate is again Insert in economic benefits and social benefits vacuum concentrator, be concentrated into every 1ml crude drug amount Han 0.1g, for component 2.By component 1 and the merging of component 2, adjust And substrate, sterilizing bottling cold preservation.

Pharmacological toxicity is tested:

Acute toxicity testing data

1, experimental technique

Depilatory is uniformly coated with by guinea pig back spinal column both sides, makes unhairing scope about 40 square centimeters.Clean depilatory Returning cage to observe 24 hours, often group Cavia porcellus is coated with the present invention 0.2,0.4 and 0.8ml respectively, respectively containing crude drug 92mg, 184mg and 368mg), another group be coated with the every twice-daily of solvent 0.8ml, continuous one week, experiment terminate after, by Cavia porcellus put to death, the heart, liver, kidney and take off Fur skin does pathological examination.

2, result

Above-mentioned three groups of medication Cavia porcellus trunks depilation district, has no that local skin has edema, hyperemia, erythema, petechia and ulcer. Medication group Cavia porcellus chroma of hair, ingest, the matched group no significant difference such as extremity are movable, histopathologic examination, the administration group heart, Liver, kidney and depilation skin compare also no significant difference with compareing word.

Result is pointed out, and external preparation of the present invention, without local irritant effect, also has no that general toxicity shows.Show that the present invention makes By safety.

Long term toxicity test data

1, experimental technique

Random for Cavia porcellus part is become 4 groups, often group 15.In guinea pig back spinal column both sides, depilatory is uniformly coated with so that it is de- Hair scope about 40 square centimeters.Clean depilatory, often organize Cavia porcellus after observing 24 hours and be coated with the present invention 0.2,0.4 and 0.8ml respectively, Respectively containing crude drug 92,184 and 368mg), another group is coated with the every twice-daily of solvent 0.8ml, continuous 30 days, observes the general feelings of Cavia porcellus Condition, experiment is put to death animal after terminating and is carried out hematology, blood biochemical and pathological examination.

2, result

Above-mentioned three groups of medication Cavia porcellus trunks go to hair-fields, have no that local skin has edema, hyperemia, erythema, petechia and ulcer. Medication group and control animals chroma of hair, ingest, matched group no significant difference, blood biochemistry checking, the medication such as extremity are movable Group and matched group are all in normal range.Histopathologic examination, tests each group of heart, liver, kidney and local skin and is showed no obvious disease Become.Prompting, Chinese medicine long-term prescription of the present invention is showed no obvious toxic action to local skin and whole body important organ.Test knot Fruit shows: experiment safety of the present invention.

Pharmacological experiment

Endo-medicine blood circulation promoting and blood stasis dispelling is tested

1 experiment material

1.1 medicine

The present invention, prepares by the method for embodiment 2；Positive control drug: SIWU TANG, prescription, Pharmacy department of the court provides.

1.2 animal Wistar rats, Kunming mouse, ♀ ♂ all uses.

2 on the impact of ALT, ET, NO content in hepatic injury mice serum

2.1 packets: take 105 kunming mices and be randomly divided into 6 groups, often group 15, A group is Normal group；B group is model Matched group；C group is positive controls；D1 group is low dose group of the present invention, and D2 group is dosage group in the present invention, and D3 group is the present invention High dose group；

2.2 modeling methods: use bacillus calmette-guerin vaccine and the united method of lipopolysaccharide to set up immunological liver injury in mice model.Each group After Animal adaptability feeds 3d, in addition to Normal group, every mice 5 × 107 viable bacterias of 1 tail vein injection bacillus calmette-guerin vaccine, in 12d intravenous injection lipopolysaccharide 7.5 μ g/ Mus after injection of BCG, puts to death after 16h and draws materials, and Normal group 2 times is all with phase Tongfang Method injection normal saline.

2.3 are administered and process: beginning gastric infusion is played in first day of intravenous injection bacillus calmette-guerin vaccine, 1 time/d.Normal group with Model control group: normal saline gavage, gavage amount is with the medication capacity of medication therapy groups；Positive control medicine treatment group: four things Soup group, 5.9g/kg dosed administration；Of the present invention group of low 3.9g/kg, middle 7.8g/kg, high 11.7g/kg dosed administration.Normal control Group is 16h after 12d injecting normal saline, and eyeball rear vein beard takes blood, and puts to death animal and take hepatic tissue censorship；Remaining group is in quiet 16h after arteries and veins injection lipopolysaccharide, eyeball rear vein beard takes blood, and puts to death animal and take hepatic tissue censorship.

2.4 observation index and detection method: 1. detect glutamate pyruvate transaminase (ALT): use chemical colorimetry to measure.2. in Endogenous nitric oxide (N0) measures: uses radioimmunology, takes 0.5g liver and make 10% liver tissue homogenate, 4 DEG C of conditions Under, 3000 turns/min, centrifugal 10min, take supernatant.3. Endothelin (ET) detection: use radiation to exempt from method and directly measure blood plasma ET Concentration.

Serum ALT respectively organized by table 1, the situation of change of ET, N0 compares

* compare with model group, * P ＜ 0.05, * * P ＜ 0.01；△ compares with positive controls, △ P ＜ 0.05.

External used medicine is tested

One, the microcirculation experimental technique of external of the present invention:

1, materials and methods: take 50 mices, is randomly divided into 5 groups, often 10 (male and female half and half) of group, matched group every Mus auris dextra Painting normal saline is a little；Positive controls every Mus auris dextra gives the south of the Five Ridges ten thousand and answers ZHITONG GAO (commercially available), and test component is outside the present invention Use spray 400mg/kg/h.15min pneumoretroperitoneum injects 0.1% pentobarbital sodium 0.1ml/10g anesthetized animal, tail vein subsequently Inject 0.1% epinephrine 0.1mL/10g, observe mouse right ear fine motion vein bore (μm) and 0.2mm2 capillary network immediately .t inspection of counting processes experimental data.

2 results and discussion

2.1. on microcirculatory impact

Compared with matched group, tested group 1 has showed increased (P ＜ 0.01) to mice capillary open number；Tested group 2 right Venule bore and capillary open number dramatically increase (P ＜ 0.01)；Tested group 3 to mice fine motion, vein bore and hair Thin vessel open number all has increase (P ＜ 0.01)；Illustrate to be improved microcirculation by reagent, have function of promoting blood circulation to disperse blood clots (table 1).

Table 1, the present invention are on mice fine motion, vein bore and the impact of capillary open number

Two, the impact on Oleum Tiglii induced mice auricle edema

Take healthy mice 30, be randomly divided into 3 groups, i.e. blank group, the south of the Five Ridges ten thousand answer ZHITONG GAO positive controls, this Bright compositions group, often organizes 10, male and female half and half, and positive controls and spray group of the present invention are smeared respectively, and blank group is coated with Smear isodose normal saline, successive administration 7 days, be administered latter 0.5 hour in last, survey outside the left in ear of mice and be coated with Oleum Tiglii cause Scorching agent (2% Oleum Tiglii, 20% dehydrated alcohol, 5% distilled water, 73% ether) 0.1ml causes inflammation, latter 4 hours of cause inflammation card punch (aperture 6mm) lays left and right auricle, weighs, and using left and right auricle weight difference as swelling degree, the results are shown in Table 2.

The table 2 impact (X ± SD) on Oleum Tiglii induced mice auricle edema

Group	Number of animals (only)	Swelling (mg)
			Blank group	10	8.57±1.72
ZHITONG GAO is answered in the south of the Five Ridges ten thousand	10	5.36±1.52**
			Of the present invention group	10	5.11±1.35#

Note: compare with matched group: * * P ＜ 0.01；Compare with positive controls: #P ＜ 0.05；Can by upper table experimental result To find out, the present composition has pharmacological action of preferably subsiding a swelling.

Three. the impact of rat paw edema caused by Carrageenan

Take healthy rat 30, body weight 180-220g, be randomly divided into blank group, ZHITONG GAO positive control is answered in the south of the Five Ridges ten thousand Group, spray group of the present invention.Often group 10, male and female half and half, sub-cage rearing.Positive controls and drug component of the present invention other every day Smearing 0.2g, blank group gives the normal saline of same dosage and smears, successive administration 7 days, is administered latter 30 minutes in last, point Only do not cause inflammation at Rat Right metapedes plantar subcutaneous injection 1% carrageenin suspension 0.1ml/, respectively at cause scorching before and cause inflammation after 15, 30, the girth surveying the Rat Right metapedes sole of the foot in 60,120,240 minutes, and calculate swelling rate [swelling rate=(cause scorching metapedes sole of the foot girth-cause Scorching front foot sole of the foot girth)/cause scorching front foot sole of the foot girth × 100%]；The results are shown in Table 3.

The impact (X ± SD) of rat paw edema caused by table 3 Carrageenan

Note: compare with matched group: * * P ＜ 0.01；Compare with positive controls: #P ＜ 0.05；Can by upper table experimental result To find out, medicine group of the present invention has the pharmacological action of blood stasis dispelling of preferably subsiding a swelling.

Talalgia is a kind of commonly encountered diseases, is characterized with heel swelling, numb pain, locally tenderness, difficulty in walking.Talalgia Also known as calcanean spur or heel bone hyperosteogeny.Belonging to " rheumatism involving the bone " category in Chinese medicine, pathogenic factor is many strains, outward with old deficiency of the kidney Hinder with to experience cold-damp relevant.YinXuXueRe refers to due to internal cloudy liquid virtual loss, the heating card caused by water failing to restrain blazing fire.Disease sees two flushed cheeks Red, emaciated physique, hectic fever night sweat, dysphoria with feverish sensation in the chest palms and soles, night fever abating at dawn, dryness of the mouth and throat, the few tongue of red tongue, thready and rapid pulse.Control suitable replenishing YIN and removing heat, Or nourishing YIN to lower pathogenic fire.YinXuXueRe, blood and essence asthenia, passages through which vital energy circulates loses and fills, then muscle is become homeless foster, and bone is become homeless master, and bone withers flaccidity of tendon and muscle, foot shin intermittent fever and Talalgia, thus when standing or walk heel ache, dull pain, weak, pain pain relieved by pressing, the alleviation of pain touched.Doctor trained in Western medicine typically solves with operation This problem, though there being certain curative effect, but planting destructive operation, being propped up by calcaneus posterior tibial nerve and propping up cut-out with sural nerve, having difference The side effect of degree or cause some complication；Chinese medicine product then because of its draw materials natural, safety good, low side effect, document Abundant information, clinical efficacy is good and enjoys favor.Medicine of the present invention acts on local, permeates skin, through sick institute, promotes QI and blood Circulation, improves local blood and runs, soften bony spur, promotes that inflammation absorbs, so that remission or elimination.Outside the present invention is for oral administration With, can effectively expand peripheral vessel, improve foot's microcirculation, blood stasis dispelling of subsiding a swelling, activating collaterals to relieve pain effect is obvious.

Claims

1. the Chinese medicine composition treating YinXuXueRe type talalgia, it is characterised in that described Chinese medicine composition is by oral medicine Thing and external used medicine form, and endo-medicine includes the crude drug of following parts by weight: the Radix Paeoniae Alba 10～20 parts, Cortex Lycii 10～20 Part, Radix Ophiopogonis 10～20 parts, Radix Rehmanniae Preparata 10～20 parts, Cortex Phellodendri 10～20 parts, Radix Polygoni Multiflori Preparata 10～20 parts, Radix Achyranthis Bidentatae 10～20 parts, Flos Carthami 10 ～20 parts, Fructus Lycii 10～20 parts, Cortex Moutan 10～20 parts, Herba Ecliptae 10～20 parts, Herba Agrimoniae 10～20 parts, the Rhizoma Anemarrhenae 10～20 parts, Rhizoma Drynariae 10～20 parts, the Cortex Eucommiae 10～20 parts, Rhizoma Corydalis 10～20 parts, Caulis Spatholobi 10～20 parts.

Described Chinese medicine composition external used medicine includes the crude drug of following parts by weight: Radix Dipsaci 10～20 parts, the Radix Angelicae Dahuricae 10～20 parts, The Pseudobulbus Bletillae (Rhizoma Bletillae) 10～20 parts, Rhizoma Chuanxiong 10～20 parts, Herba speranskiae tuberculatae 10～20 parts, Radix Notoginseng 10～20 parts, Olibanum 10～20 parts, Myrrha 10～20 Part, Rhizoma Et Radix Notopterygii 10～20 parts, Folium Artemisiae Argyi 10～20 parts, Radix Clematidis 10～20 parts, Radix Saposhnikoviae 10～20 parts.

Treat the Chinese medicine composition of YinXuXueRe type talalgia the most according to claim 1, it is characterised in that described Chinese drug-treated group In compound, endo-medicine includes the crude drug of following parts by weight: the Radix Paeoniae Alba 10～15 parts, Cortex Lycii 10～15 parts, Radix Ophiopogonis 10～15 Part, Radix Rehmanniae Preparata 10～15 parts, Cortex Phellodendri 10～15 parts, Radix Polygoni Multiflori Preparata 10～15 parts, Radix Achyranthis Bidentatae 10～15 parts, Flos Carthami 10～15 parts, Fructus Lycii 10 ～20 parts, Cortex Moutan 10～20 parts, Herba Ecliptae 10～20 parts, Herba Agrimoniae 10～20 parts, the Rhizoma Anemarrhenae 10～20 parts, Rhizoma Drynariae 10～20 Part, the Cortex Eucommiae 10～20 parts, Rhizoma Corydalis 10～20 parts, Caulis Spatholobi 10～20 parts.

In described Chinese medicine composition, external used medicine includes the crude drug of following parts by weight: Radix Dipsaci 10～15 parts, the Radix Angelicae Dahuricae 10～15 Part, the Pseudobulbus Bletillae (Rhizoma Bletillae) 10～15 parts, Rhizoma Chuanxiong 10～15 parts, Herba speranskiae tuberculatae 10～15 parts, Radix Notoginseng 10～15 parts, Olibanum 10～20 parts, Myrrha 10 ～20 parts, Rhizoma Et Radix Notopterygii 10～20 parts, Folium Artemisiae Argyi 10～20 parts, Radix Clematidis 10～20 parts, Radix Saposhnikoviae 10～20 parts.

Treat the Chinese medicine composition of YinXuXueRe type talalgia the most according to claim 1, it is characterised in that described Chinese drug-treated group In compound, endo-medicine includes the crude drug of following parts by weight: the Radix Paeoniae Alba 10～20 parts, Cortex Lycii 10～20 parts, Radix Ophiopogonis 10～20 Part, Radix Rehmanniae Preparata 10～20 parts, Cortex Phellodendri 10～20 parts, Radix Polygoni Multiflori Preparata 10～20 parts, Radix Achyranthis Bidentatae 10～20 parts, Flos Carthami 10～20 parts, Fructus Lycii 10 ～15 parts, Cortex Moutan 10～15 parts, Herba Ecliptae 10～15 parts, Herba Agrimoniae 10～15 parts, the Rhizoma Anemarrhenae 10～15 parts, Rhizoma Drynariae 10～15 Part, the Cortex Eucommiae 10～15 parts, Rhizoma Corydalis 10～15 parts, Caulis Spatholobi 10～15 parts.

In described Chinese medicine composition, external used medicine includes the crude drug of following parts by weight: Radix Dipsaci 10～20 parts, the Radix Angelicae Dahuricae 10～20 Part, the Pseudobulbus Bletillae (Rhizoma Bletillae) 10～20 parts, Rhizoma Chuanxiong 10～20 parts, Herba speranskiae tuberculatae 10～20 parts, Radix Notoginseng 10～20 parts, Olibanum 10～15 parts, Myrrha 10 ～15 parts, Rhizoma Et Radix Notopterygii 10～15 parts, Folium Artemisiae Argyi 10～15 parts, Radix Clematidis 10～15 parts, Radix Saposhnikoviae 10～15 parts.

4. as according to any one of claims 1 to 3, treat a preparation method for YinXuXueRe type talalgia Chinese medicine composition, It is characterized in that, described endo-medicine is that the preparation method of tablet comprises the following steps:

A. the extraction of raw material medicinal alcohol is taken, as component 1；

C. by 2-in-1 for component 1 component and be condensed into extractum, add starch or dextrin is in harmonious proportion film-making.

The preparation side of the endo-medicine tablet for the treatment of YinXuXueRe type talalgia Chinese medicine composition the most according to claim 4 All crude drug are shredded by method, it is characterised in that in described step a, are soaked and have been placed in lid stainless steel cask, add 70% Ethanol, quality is coarse grained 0.8-1 times, stirs, moistening airtight placement more than 1 hour, makes fully to expand；By percolation Bottom Tong filter plate gauze bag parcel pave after again the drug sample after moistening expansion is mixed pine do dissipate, then with rustless steel spoon contain Powder, loads percolator uniformly, fills 10-12 cm thick, even by T-bar pressure, then presses aforesaid operations, and loading in layer is suitable Working as pressurization, medicated powder loads 2/3 eminence that must not exceed percolator；Medicated powder face upper cover rustless steel orifice plate fastens, and opens under percolator The baiting valve in face, and put a container, then it is slowly added into 70% ethanol；Air between medicated powder powder to be discharged, and have second Alcohol flows out about about 20L, closes baiting valve, covers cylinder of filtering, dipping 24 hours, then opens baiting valve and carries out percolation, controls percolation Speed is generally 1000g medical material outflow per minute 2～3ml, and filtrate puts into liquid container, and pours ethanol during emptying into storage Fluid cylinder；Being merged by percolate and stand, stand for standby use, as component 1.

The preparation side of the endo-medicine tablet of the Chinese medicine composition for the treatment of YinXuXueRe type talalgia the most according to claim 4 Method, it is characterised in that in described step b, puts in 10 times amount water by above-mentioned stripped raw material residue, soaks 1-2 hour, add Heat is extracted 2 times, each 1-2 hour, removes supernatant, united extraction liquid, and 100-120 mesh filters, then through the molecular weight that dams be 5000- The ultrafiltration post ultrafiltration of 10000, the filtrate of 1.05 when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C, as component 2.

The preparation of tablet in the endo-medicine of the Chinese medicine composition for the treatment of YinXuXueRe type talalgia the most according to claim 4 Method, it is characterised in that in described step c, by 2-in-1 also to component 1 and component, put in economic benefits and social benefits vacuum concentrator and mixes, and first will When filtrate is concentrated into 80 DEG C, relative density is the concentrated solution of 1.32, sets to 0～5 DEG C of deepfreezes 24 hours；Cold preservation liquid is added 0.3% Filter aid kieselguhr, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml extractum Han 0.1g, then adds paste Essence or starch tabletting, pack.

8. as according to any one of claims 1 to 3, treat a preparation method for YinXuXueRe type talalgia Chinese medicine composition, It is characterized in that, the preparation method of the external preparation spray of described Chinese medicine composition is following steps:

B. remaining raw material ethanol is extracted, concentrate, as component 2；

The system of the spray of the external used medicine of the Chinese medicine composition for the treatment of YinXuXueRe type talalgia the most according to claim 4 Preparation Method, it is characterised in that in described step a, first steams crude drug Radix Notoginseng, the Radix Angelicae Dahuricae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Rhizoma Et Radix Notopterygii and Radix Saposhnikoviae steam method Evaporate, obtain crystal, then pulverize, cross 100-120 mesh sieve, standby as component 1.

Treat the spray of the external used medicine of the Chinese medicine composition of YinXuXueRe type talalgia the most according to claim 4 Preparation method, it is characterised in that in described step b, shreds remaining crude drug, is soaked and has been placed in lid stainless steel cask, Adding 70% ethanol, quality is coarse grained 0.8-1 times, stirs, moistening airtight placement more than 1 hour, makes fully to expand； By bottom percolator filter plate gauze bag parcel pave after again the drug sample after moistening expansion is mixed pine do dissipate, then with stainless Powder contained by steel spoon, loads percolator uniformly, fills 10-12 cm thick, even by T-bar pressure, then presses aforesaid operations, dress in layer Entering, suitably pressurize, medicated powder loads 2/3 eminence that must not exceed percolator；Medicated powder face upper cover rustless steel orifice plate fastens, and opens percolation Cylinder baiting valve below, and put a container, then it is slowly added into 70% ethanol；Air between medicated powder powder to be discharged, and There is ethanol to flow out about about 20L, close baiting valve, cover cylinder of filtering, dipping 24 hours, then open baiting valve and carry out percolation, control Percolation speed is generally 1000g medical material outflow per minute 2～3ml, and filtrate puts into liquid container, and is fallen by ethanol during emptying Enter liquid container；Percolate is merged and stands, as component 2；Component 1 is put in component 2, stirs, solubilizer, load spray In day with fog.