CN105920421A - Traditional Chinese medicinal preparation for treating chronic appendicitis and preparation method thereof - Google Patents
Traditional Chinese medicinal preparation for treating chronic appendicitis and preparation method thereof Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicinal preparation for treating chronic appendicitis and a preparation method thereof. The traditional Chinese medicinal preparation is prepared from the following medicinal materials of incarvillea arguta herba, cinnamomum camphora bark and root, hairyleaf litse fruit, schisandra propinqua rattan and root, Wedelia urticifolia DC. root, Aralia echinocaulis Hand.-Mazz. root-bark of Spinystem Aralia, hoya lancilimba stem leaf, tamarindus indica linn fruit, puccinellia tenuiflora herba, herba junci setchuensis, Centaurium pulchellum (Swartz) Druce var. altaicum herba with flower, herba viola inconspicua Bl, berchemia lineata root and leaf, scandent hop herba and rhizoma polygoni runcinati. The traditional Chinese medicinal preparation has the beneficial effects of safety and convenience in use, and no toxic and side effects and adverse reactions; the traditional Chinese medicinal preparation can be used together with western medicine conventional medicaments for treating chronic appendicitis, thereby enhancing the treatment effect of western medicines.
Description
Technical field
The present invention relates to engineering of traditional Chinese medicine technical field, particularly relate to a kind of Chinese medicine treating chronic appendicitis
Preparation and preparation method thereof.
Background technology
Chronic appendicitis is the most common frequently-occurring disease, be disappear because of vermiform appendix acute inflammation after the door screen left over
Tail chronic inflammatory conditions, such as tube wall fibre structure hamartoplasia, luminal stenosis or obturation, torsion of appendix,
With surrounding structure tissue adhesion etc..The clinical right lower abdomen pain that shows as more, body temperature raises, vomit with in
Property the performance such as granulocytosis.Doctor trained in Western medicine, mainly based on operation, coordinates anti-inflammatory treatment, and the traditional Chinese medical science thinks that this is sick
Belong to " acute appendicitis " category, mostly use Chinese medical discrimination to treat.
Acute appendicitis is that pyretic toxicity is cohesion, in stasis intestinal, and a kind of disease of raw pus of carbuncle.It is clinical with fever with chills,
Swelling and oppresive sensation of the lower abdomen.Pain contracture is characterized.Primary disease many by feed savoury, addiction to uncooked and cold food and eating and drinking too much at one meal etc. because of,
So that taste are impaired, gastrointestinal development of evil in febrile disease function is unfavorable, and mechanism of qi is jammed and forms；Or cruelly run because of anxious on a full stomach,
Or tumbling down damage, causing intestinal internal organs injury of small vessels, blood stasis stagnates, intestinal internal organs heat-transformation, and stagnation of blood stasis and heat causes blood
Lose meat corruption and form pus of carbuncle." Waike Zhengzong, Orthodox Manual of External Diseases " rolls up three: " acute appendicitis person, the most damp and the hottest blood stasis stream forms in small intestinal
Also.Origin has three: man the most suddenly runs, thus the intestines and stomach transmission can not Shu Li, deteriorated blood foul smell is stopped up and is held back and form
Person one is also；Married woman puerperal, body void drowsiness, sit without rising, again or confinement in childbirth (tire products) is difficult, exert oneself the most too
Cross, lose after educating by losing the stasis of blood, so that deteriorated blood stops long-pending the intestines and stomach, tie stagnant and winner two also；Hungry full impairment caused by overstrain, undertakes
Weight, the intestines and stomach of causing injury, again or liquor-saturated full exhaustion due to sexual indulgence, cross and hinder energy, or raw food is gone forward side by side, coagulation of QI-blood and winner
Three also ".The thing that eating and drinking without temperance, eating and drinking too much at one meal, or surfeit are greasy, raw and cold, unclean, damages the intestines and stomach, damp and hot
Inside accumulate between intestinal；Or because drastically running after diet, causing qi depression to blood stasis, intestinal network is impaired；Or because cold temperature is uncomfortable,
Tumbling down damages, Nervous and Mental Factors etc., causes the stagnation of QI, blood stasis, dampness, heat to be stopped up, and the stasis of blood is stagnant, accumulated heat does not dissipates, and blood is rotten
Meat loses and forms carbuncle.Modern medicine is thought, appendiceal lumen blocks that to infect with antibacterial be that the principal pathogenetic of primary disease is former
Cause.About the treatment of acute appendicitis, " Medical Treasures of the Golden Chamber " has a load: " acute appendicitis person, swelling and oppresive sensation of the lower abdomen, the i.e. pain pressed,
As drench, normal urination, fever occurring frequently, from sweating, aversion to cold again, its slow pulse tight person pus does not becomes, can purgation,
When there being blood；Full and rapid pulse person, formed pus, purgative being prohibited also, Dahuang Mudan skin soup master it ".
Summary of the invention
The technical problem to be solved is, utilizes the theory of Chinese medical science that China is traditional, it is provided that a kind of
Chinese medicine preparation for the treatment of chronic appendicitis and preparation method thereof, this Chinese medicine can coordinate conventional western medicine to use,
Improve the therapeutic effect of Western medicine, and have no side effect.
In order to solve above-mentioned technical problem, the invention provides a kind of Chinese medicine preparation treating chronic appendicitis,
Described Chinese medicine preparation includes following raw medicinal material: suona horn flower, monkey nanmu, clear Fructus Solani melongenae, Herba Schisandrae intermediae, root of bleeding,
Redwood, Herba Hoyae lancilimbae, Fructus Tamarindi Indicae, Flos Eragrostinis cilianensis, Herba Poae Sphondylodis, Herba centaurll altaici, Herba Violae Inconspicui, Radix berchemiae lineatae, grass and
Herba Polygoni Runcinati.
The ratio of weight and number of the various raw medicinal materials in described Chinese medicine preparation can be preferably: suona horn spend 20～
30 parts, monkey nanmu 15～25 parts, clear Fructus Solani melongenae 10～20 parts, Herba Schisandrae intermediae 10～20 parts, bleed root 20～
30 parts, redwood 5～15 parts, Herba Hoyae lancilimbae 10～20 parts, Fructus Tamarindi Indicae 15～25 parts, Flos Eragrostinis cilianensis 20～30
Part, Herba Poae Sphondylodis 10～20 parts, Herba centaurll altaici 12～22 parts, Herba Violae Inconspicui 20～30 parts, Radix berchemiae lineatae 15～25
Part, grass 10～20 parts and Herba Polygoni Runcinati 15～25 parts.
The ratio of weight and number of the various raw medicinal materials in described Chinese medicine preparation can also be more preferably: Suo
Spend 20～25 parts, monkey nanmu 17～22 parts, clear Fructus Solani melongenae 13～18 parts, Herba Schisandrae intermediae 10～15 part, droplet
Red root 25～30 parts, redwood 8～13 parts, Herba Hoyae lancilimbae 12～17 parts, Fructus Tamarindi Indicae 18～23 parts, star
Grass 20～25 parts, Herba Poae Sphondylodis 13～18 parts, Herba centaurll altaici 15～20 parts, Herba Violae Inconspicui 22～27 parts, ferrum bag
Gold 17～22 parts, grass 10～15 parts and Herba Polygoni Runcinati 18～23 parts.
The ratio of weight and number of the various raw medicinal materials in described Chinese medicine preparation can also be more preferably: Suo
Spend 24 parts, monkey nanmu 18 parts, clear Fructus Solani melongenae 17 parts, Herba Schisandrae intermediae 14 parts, bleed root 25 parts, redwood
12 parts, Herba Hoyae lancilimbae 13 parts, Fructus Tamarindi Indicae 22 parts, Flos Eragrostinis cilianensis 21 parts, Herba Poae Sphondylodis 17 parts, Herba centaurll altaici 16 parts,
Herba Violae Inconspicui 26 parts, Radix berchemiae lineatae 18 parts, grass 14 parts and Herba Polygoni Runcinati 20 parts.
The ratio of weight and number of the various raw medicinal materials in described Chinese medicine preparation can also be more preferably: Suo
Spend 20 parts, monkey nanmu 20 parts, clear Fructus Solani melongenae 14 parts, Herba Schisandrae intermediae 10 parts, bleed root 28 parts, redwood
10 parts, Herba Hoyae lancilimbae 16 parts, Fructus Tamarindi Indicae 20 parts, Flos Eragrostinis cilianensis 25 parts, Herba Poae Sphondylodis 15 parts, Herba centaurll altaici 20 parts,
Herba Violae Inconspicui 24 parts, Radix berchemiae lineatae 20 parts, grass 10 parts and Herba Polygoni Runcinati 22 parts.
When the dosage form of described Chinese medicine preparation is oral solutions, its preparation method comprises the following steps:
The first step, by suona horn flower, monkey nanmu, clear Fructus Solani melongenae, Herba Schisandrae intermediae, bleed root and redwood mixing, adds
Relative to 3 times of mixture～alcohol reflux that 5 times amount determining alcohols are 55%～65% 2 times～4 times,
Each 2 hours～3 hours, filtering, filtrate merges, and reclaims ethanol, and being concentrated into 70 DEG C of relative densities is
The mastic of 1.30～1.32, standby；
Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 3～5 times amount water, boils
Boil 2～4 hours, filter, be concentrated into the mastic that 70 DEG C of relative densities are 1.27～1.29；
3rd step, the described mastic mixing that the first step, second step are obtained, 55 DEG C～65 DEG C of reduced vacuum
Being dried, get dry extract powder；
4th step, added ethanol in the described dried cream powder the 3rd step obtained, obtains containing alcohol mastic, described
The alcohol content of containing alcohol mastic is 65%～70%；Described containing alcohol mastic is carried out chilling treatment, precipitation successively
Process, filtration treatment, recovery Ethanol Treatment, obtain dealcoholysis mastic, wherein, the chilling treatment time be 30～
40 hours, refrigerated storage temperature was 2 DEG C～6 DEG C；
5th step, will in described dealcoholysis mastic add cane sugar powder, activated carbon, carry out successively heat treated,
Filtration treatment, dilution process, and obtain semi-finished product；Described dealcoholysis mastic with the weight ratio of described cane sugar powder is
1: 0.1～0.3；Described dealcoholysis mastic is 1: 0.001～0.002 with the weight ratio of described activated carbon；Institute
The time stating heat treated is 20～40 minutes, and temperature is 100 DEG C～110 DEG C；
6th step, then by the 5th step obtain described semi-finished product carry out successively filtration treatment, embedding process,
Sterilization treatment, obtains described Chinese medicine preparation oral liquid finished product.
When the dosage form of described Chinese medicine preparation is powder, its preparation method comprises the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, add relative to mixture quality 2～
The determining alcohol of 4 times is the ethanol of 85～95%, is heated to reflux 1～3 hour, extracts, and filters acquisition first
Extracting solution；Filter obtain medicinal residues add relative to the determining alcohol of described medicinal residues quality 1～2 times be 85～
The ethanol of 95%, is heated to reflux 1～3 hour, extracts, and filters and obtains the second extracting solution；Extract first
Liquid and the second extracting solution merge, and concentrating under reduced pressure removes alcohol solvent, are dried, it is thus achieved that dry cream；
Second step, is placed in super micron mill pulverizing 1～2 hour by the dry cream that the first step obtains, and pulverizes,
Sieve, it is thus achieved that 300 mesh～the micropowders of 400 mesh；
3rd step, adds relative to its quality 2～the shallow lake of 4 times in the micropowders obtained by second step
Powder, mixing, it is thus achieved that powder.
Beneficial effects of the present invention: the Chinese medicine preparation of the present invention, safe and convenient to use, have no side effect and
Untoward reaction, it is possible to coordinate doctor trained in Western medicine routine medication chronic appendicitis, improves the therapeutic effect of Western medicine.
Detailed description of the invention
The invention provides a kind of Chinese medicine preparation treating chronic appendicitis, Chinese medicine preparation includes following former
Material medical material: suona horn flower, monkey nanmu, clear Fructus Solani melongenae, Herba Schisandrae intermediae, root of bleeding, redwood, Herba Hoyae lancilimbae, Fructus Tamarindi Indicae,
Flos Eragrostinis cilianensis, Herba Poae Sphondylodis, Herba centaurll altaici, Herba Violae Inconspicui, Radix berchemiae lineatae, grass and Herba Polygoni Runcinati.
The pharmacology of various raw medicinal materials is as follows:
Suona horn flower: [another name] Herba Incarvilleae argutae, big gun is swollen cylinder, Radix et Rhizoma Thalictri, sheep milk are sub, the Yanshan Mountain is red, sheep tail
Chicken tail careless, yellow, toilet flower, Mel flower, thousand cuttves, two capillus.Salar flower, broken bowl flower, big flower pesticide,
Big gun is swollen flower, Folium Cannabis, cotton grass, rock trumpet flower, big nine add, city wall flower.[source] medical material base
Source: for the band rhizome herb of Bignoniaceae tree planting thing Herba Melicae Scabrosae.[nature and flavor] bitter in the mouth；Micro-pungent；Property flat.[merit
Can cure mainly] invigorating spleen to remove dampness；Promoting flow of QI and blood.Master has loose bowels；Dysentery；Stomachache；Hypochondriac pain；Rheumatalgia；Month
Through uncomfortable；Carbuncle；Fracture.[extracts] " China's book on Chinese herbal medicine "
Monkey nanmu: [another name] Radix Cinnamomi porrecti, ox tendon strip, Niu Jingshu.[source] Lauraceae Cortex cinnamomi bodinieri radicis (Cinnamomum bodnieri Levl.), with root bark,
Fruit medicine.[nature and flavor] are micro-pungent, temperature.[function cures mainly] wind dispelling, circulation of qi promoting, warming middle-JIAO, analgesia.Main
Control gastroenteritis, anemofrigid cold, rheumatic numbness, impairment caused by overstrain pain.Burn and scald is controlled in external.[extracts] is " complete
State's Chinese herbal medicine compilation "
Clear Fructus Solani melongenae: [another name] Fructus Linderae Glaucae, taste spicy, Fructus Litseae, Fructus Litseae pungentis, Litsea chenii, wild pepper,
Smelly Camphor tree.[source] medical material Ji Yuan: for the fruit of canella cubeb litsen tree.[nature and flavor] are pungent；Micro-hardship；
Temperature.[return through] spleen；Stomach；Kidney channel.[function cures mainly] warming middle-JIAO to relieve pain；Promoting flow of QI and blood；Relieving asthma；Profit
Urine.Main coldness and pain in the epigastrium；Food stagnation flatulence；Regurgitation is vomitted；Heatstroke is vomited and diarrhoea；Dysentery；Colic of cold type is suffered from abdominal pain；
Asthma；Cold-damp dropsy；Dysuria；Turbid urine；Sore swollen toxin；Toothache；Arthralgia due to cold-dampnes；Traumatic injury
Damage.[extracts] " China's book on Chinese herbal medicine "
Herba Schisandrae intermediae: [another name] Herba Schisandrae intermediae, ventilation perfume, Schisandra propinqua (Wall.) Baill. Var. intermedia A. Smith, Radix seu Caulis Schisandrae Sinensis, Drugs of Snake Venom, Herba Sidae Szechuensis,
Little red robe, rock Folium Isatidis, Radix Campylotropis Hirtella (Herba Myrsines Africanae), MANSHANXIANG, sliding rattan, purple dragon, Caulis seu Radix Schisandrae Henryi, five Radix Stauntoniae chinensis.[source]
Medical material Ji Yuan: close rattan and the root of stamen Fructus Schisandrae Chinensis for Schisandraceae Plant.[nature and flavor] are bitter；Pungent；Property flat.
[return through] Liver Channel.[function cures mainly] heat-clearing and toxic substances removing；Promoting blood circulation and detumescence.Main flow sense；Carbuncle sore tumefacting virus；Poison
Venom；Rheumatic numbness；Traumatic injury；Menoxenia.[extracts] " China's book on Chinese herbal medicine "
Bleed root: [another name] Radix seu Caulis Schisandrae Sinensis, Rhizoma seu Herba Elatostematis stewardii, NVJIN DAN.[source] medical material Ji Yuan: for chrysanthemum
The root of section's plant Folium Cannabis Herbia Wedeliae.[nature and flavor] sweet in the mouth；Warm in nature.[function cures mainly] the kidney invigorating；Nourish blood；
Dredging collateral.Main lumbago due to renal deficiency；Deficient qi and blood；Traumatic injury.[extracts] " China's book on Chinese herbal medicine "
Redwood: [another name] red Herba Damnacanthi, llex cornuta, HONGCI cylinder, red Ramulus Kalopanacis seu Araliae, red burr paulownia,
Red llex cornuta thorn, HONGCI paulownia, tiger green pepper thorn, thousand pieces of pins, red autumnal leaves big cat thorn, red autumnal leaves umbrella thorn, HONGCI party,
Thorn stem wood.[source] medical material Ji Yuan: for root and the root bark of Araliaceae spine stem wood.[nature and flavor]
Mildly bitter flavor；Pungent；Property flat.[function cures mainly] expelling wind and removing dampness；Blood-activating and qi-promoting；Removing toxic substances and promoting subsidence of swelling.Main air is wet
Arthralgia pain；Treating swelling and pain by traumatic injury；Fracture；Epigastric distending pain；Hernia；Metrorrhagia；Osteomyelitis；Carbuncle；Venom [is plucked
Record] " China's book on Chinese herbal medicine "
Herba Hoyae lancilimbae: [another name] sword-like leave Caulis seu folium hoyaecarnosae, soil, great Ye Pseudobulbus Pholidotae Chinensis, SHILONG rattan in five.[source]
Medical material Ji Yuan: for the stem and leaf of dicotyledon Yao Luo section plant Herba Hoyae lancilimbae.[nature and flavor] are bitter；Pungent；Cool.
[return through] Liver Channel.[function cures mainly] promoting blood circulation to remove blood stasis；Expelling wind and removing dampness.Main air damp-heat arthralgia；Treating swelling and pain by traumatic injury；
Fracture.[extracts] " China's book on Chinese herbal medicine "
Fructus Tamarindi Indicae: [another name] acid dumpling, dark plum, Man Mu, Radix seu Caulis Kadsurae Heteroclitae.[source] medical material Ji Yuan: for bean
The fruit of section's plant tamarind.[nature and flavor] sweet acid；Cool.[return through] heart；Stomach warp.[function cures mainly]
Clearing away summer-heat；Stomach function regulating removing food stagnancy.Main heatstroke；Inappetence；Infantile malnutrition；Vomiting during pregnancy；Constipation.[pluck
Record] " China's book on Chinese herbal medicine "
Flos Eragrostinis cilianensis: [another name] Herba Eragrostidis pilosae, palmate meadowsweet.[source] grass family big picture of Eragrostis plant
Eyebrow grass, Herba Eragrostidis pilosae and the herb of Herba Eragrostidis Poaeoidis, its inflorescence is the most pharmaceutically acceptable.Autumn in herb summer gathers, and inflorescence exists
Florescence adopts, and cleans cutting, dries.[nature and flavor] herb: sweet, light is cool.Inflorescence: light is flat.[merit
Can cure mainly] herb: wind and heat dispersing, diuresis.For vesical calculus, renal calculus, nephritis, pyelonephritis,
Cystitis, conjunctivitis, keratitis.Inflorescence: removing toxic substances, antipruritic.For impetigo.[extracts] is " complete
State's Chinese herbal medicine compilation "
Herba Poae Sphondylodis: [source] is the aerial parts of grass Poa sphondylodes.Summer, autumn gather,
Dry.[nature and flavor] are sweet light, flat.[function cures mainly] heat-clearing and toxic substances removing, diuresis, pain relieving.Control urine leaching
Puckery, impetigo.[extracts] " Chinese medicine voluminous dictionary "
Herba centaurll altaici: [source] medical material Ji Yuan: for the wounded in the battle herb of gentianaceae plant Centaurium meyeri Druce.[nature and flavor]
Bitter；Cold in nature.[return through] liver；Stomach warp.[function cures mainly] heat-clearing and toxic substances removing.Main hepatitis；Cholecystitis；
Have a headache and fever；Toothache；Tonsillitis.[extracts] " China's book on Chinese herbal medicine "
Herba Violae Inconspicui: [another name] examination Rhizoma Acori Graminei, Hua Koucao, Herba violae patrinii, Herba Violae, Viola inconspicua Blume, colter
Grass, chicken lower jaw grass, chicken dispute, Herba Violae, Herba violae patrinii, plough nozzle dish, share beak dish, arrow public affairs careless, red
Chicken beats mutually.[source] medical material Ji Yuan: for the herb of Violaceae plant viola inconspicua Blume.[nature and flavor] bitter in the mouth；
Pungent；Cold in nature.[function cures mainly] heat-clearing and toxic substances removing；Removing heat from blood is subsided a swelling；Dampness removing blood stasis dispelling.Main furuncle carbuncle；Pharynx
Larynx swells and ache；Acute mastitis；Jaundice due to damp-heat；Conjunctival congestion corneal nebula；Acute appendicitis hematochezia；Traumatic injury；Traumatic hemorrhage；Woman
Female's postnatal blood stasis is suffered from abdominal pain；Snake bite and insect sting.[extracts] " China's book on Chinese herbal medicine "
Radix berchemiae lineatae: [another name] Canis familiaris L. foot profit, carry cloud Flos persicae careless, little, mouse grass, Ramulus et Folium Berchemiae Lineatae, mouse black,
Molluscum contagiosum head, coal rattan, mouse breast, Mus rice, crow stasis of blood head, crow Lee chinaberry, oolong root, crow youngster young, small size
Radix berchemiae lineatae, crow Herba Epigeneii fargesii, mouse dung.[source] medical material Ji Yuan: the covered with gold leaf and light branch for Rhamnaceae plant iron
The ratan of Radix Berchemiae Giraldianae or root.[nature and flavor] are bitter；Micro-puckery；Flat.[return through] heart；Lung meridian.[function master
Control] subduing swelling and detoxicating；Hemostatic analgesia；Expelling wind and removing dampness.Main carbuncle furunculosis；Cough spitting of blood；Digestive tract hemorrhage；
Traumatic injury；Scald；Rheumatic ostalgia；Acute toothache.[extracts] " China's book on Chinese herbal medicine "
Grass: [another name] Le grass, blackwort symphytum, Caulis Puerariae lobatae, Ge Leman, to come poisonous weeds, Pueraria lobota careless, puckery
LUOMAN, cut people rattan, Caulis Momordicae Charantiae, Galium spurium L., draw rattan, Herba Ipomoeae Cairicae, great Ye Herba Ipomoeae Cairicae.[source]
Medical material Ji Yuan: for the herb of moraceae plants grass.[nature and flavor] are sweet；Bitter；Cold in nature.[return through] lung；
Kidney channel.[function cures mainly] heat-clearing and toxic substances removing；Inducing diuresis for treating stranguria syndrome；.Main cough due to lung-heat；Lung abscess；Deficiency-heat excessive thirst；
Pyretic stranguria；Edema；Dysuria；Damp-heat dysentery；Pathopyretic ulcer；Skin pruritus.[extracts] " China
Book on Chinese herbal medicine "
Herba Polygoni Runcinati: [another name] soil is done one's utmost, Polygonum runcinatum Buch.Ham, Hua Lianqiao, Qiao Zilian, Herba Polygoni Runcinati, flower shoulder pole,
Herba Senecionis Chrysanthemoidis, dissipate blood company, little dizzy medicine, paint face swoon medicine, red soap medicine, Folium Ligustri pubescentis head grass, Herba Strobilanthis Japonici, buckwheat Rhizoma Coptidis,
Wide Sichuan Cordyceps, sweet Qiao Lian, swelling of the feet grass, field are withered seven, Rhizoma petasitis japonici, Herba Polygoni Runcinati, bucket flower are itched, south snakehead, butterfly
Butterfly grass, Bleeding-Stopping Bolus, grass see blood, Polygonum runcinatum var. sinense Hemsl., yellow Herba Lycopi, paint face's Semen Fagopyri Esculenti, sub-waist mountain knotweed, Thalictrum microgynum Lecoyer ex Oliv,
Radix Ardisiae Punctatae, Hua Yuetian, Pan Jiaolian, Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae).[source] medical material Ji Yuan: for polygonaceae plant Herba Polygoni Runcinati
Herb with scarce waist leaf knotweed.[nature and flavor] are bitter；Micro-acid；Puckery；Property flat.[function cures mainly] heat-clearing and toxic substances removing；
Relaxing muscles and tendons to promote blood circulation.Main dysentery；Have loose bowels；Leucorrhea with red and white discharge；Amenorrhea；Dysmenorrhea；Acute mastitis；Furuncle；Innominate toxic swelling；
Venom；Traumatic injury；Impairment caused by overstrain lumbago.[extracts] " China's book on Chinese herbal medicine "
The ratio of weight and number of the various raw medicinal materials in described Chinese medicine preparation can be preferably: suona horn spend 20～
30 parts, monkey nanmu 15～25 parts, clear Fructus Solani melongenae 10～20 parts, Herba Schisandrae intermediae 10～20 parts, bleed root 20～
30 parts, redwood 5～15 parts, Herba Hoyae lancilimbae 10～20 parts, Fructus Tamarindi Indicae 15～25 parts, Flos Eragrostinis cilianensis 20～30
Part, Herba Poae Sphondylodis 10～20 parts, Herba centaurll altaici 12～22 parts, Herba Violae Inconspicui 20～30 parts, Radix berchemiae lineatae 15～25
Part, grass 10～20 parts and Herba Polygoni Runcinati 15～25 parts.
The ratio of weight and number of the various raw medicinal materials in described Chinese medicine preparation can also be more preferably: Suo
Spend 20～25 parts, monkey nanmu 17～22 parts, clear Fructus Solani melongenae 13～18 parts, Herba Schisandrae intermediae 10～15 part, droplet
Red root 25～30 parts, redwood 8～13 parts, Herba Hoyae lancilimbae 12～17 parts, Fructus Tamarindi Indicae 18～23 parts, star
Grass 20～25 parts, Herba Poae Sphondylodis 13～18 parts, Herba centaurll altaici 15～20 parts, Herba Violae Inconspicui 22～27 parts, ferrum bag
Gold 17～22 parts, grass 10～15 parts and Herba Polygoni Runcinati 18～23 parts.
The ratio of weight and number of the various raw medicinal materials in described Chinese medicine preparation can also be more preferably: Suo
Spend 24 parts, monkey nanmu 18 parts, clear Fructus Solani melongenae 17 parts, Herba Schisandrae intermediae 14 parts, bleed root 25 parts, redwood
12 parts, Herba Hoyae lancilimbae 13 parts, Fructus Tamarindi Indicae 22 parts, Flos Eragrostinis cilianensis 21 parts, Herba Poae Sphondylodis 17 parts, Herba centaurll altaici 16 parts,
Herba Violae Inconspicui 26 parts, Radix berchemiae lineatae 18 parts, grass 14 parts and Herba Polygoni Runcinati 20 parts.
The ratio of weight and number of the various raw medicinal materials in described Chinese medicine preparation can also be more preferably: Suo
Spend 20 parts, monkey nanmu 20 parts, clear Fructus Solani melongenae 14 parts, Herba Schisandrae intermediae 10 parts, bleed root 28 parts, redwood
10 parts, Herba Hoyae lancilimbae 16 parts, Fructus Tamarindi Indicae 20 parts, Flos Eragrostinis cilianensis 25 parts, Herba Poae Sphondylodis 15 parts, Herba centaurll altaici 20 parts,
Herba Violae Inconspicui 24 parts, Radix berchemiae lineatae 20 parts, grass 10 parts and Herba Polygoni Runcinati 22 parts.
When the dosage form of described Chinese medicine preparation is oral solutions, and it comprises the following steps:
The first step, by suona horn flower, monkey nanmu, clear Fructus Solani melongenae, Herba Schisandrae intermediae, bleed root and redwood mixing, adds
Relative to 3 times of mixture～alcohol reflux that 5 times amount determining alcohols are 55%～65% 2 times～4 times,
Each 2 hours～3 hours, filtering, filtrate merges, and reclaims ethanol, and being concentrated into 70 DEG C of relative densities is
The mastic of 1.30～1.32, standby；
Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 3～5 times amount water, boils
Boil 2～4 hours, filter, be concentrated into the mastic that 70 DEG C of relative densities are 1.27～1.29；
3rd step, the described mastic mixing that the first step, second step are obtained, 55 DEG C～65 DEG C of reduced vacuum
Being dried, get dry extract powder；
4th step, added ethanol in the described dried cream powder the 3rd step obtained, obtains containing alcohol mastic, described
The alcohol content of containing alcohol mastic is 65%～70%；Described containing alcohol mastic is carried out chilling treatment, precipitation successively
Process, filtration treatment, recovery Ethanol Treatment, obtain dealcoholysis mastic, wherein, the chilling treatment time be 30～
40 hours, refrigerated storage temperature was 2 DEG C～6 DEG C；
5th step, will in described dealcoholysis mastic add cane sugar powder, activated carbon, carry out successively heat treated,
Filtration treatment, dilution process, and obtain semi-finished product；Described dealcoholysis mastic with the weight ratio of described cane sugar powder is
1: 0.1～0.3；Described dealcoholysis mastic is 1: 0.001～0.002 with the weight ratio of described activated carbon；Institute
The time stating heat treated is 20～40 minutes, and temperature is 100 DEG C～110 DEG C；
6th step, then by the 5th step obtain described semi-finished product carry out successively filtration treatment, embedding process,
Sterilization treatment, obtains described Chinese medicine preparation oral liquid finished product.
When the dosage form of described Chinese medicine preparation is powder, and it comprises the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, add relative to mixture quality 2～
The determining alcohol of 4 times is the ethanol of 85～95%, is heated to reflux 1～3 hour, extracts, and filters acquisition first
Extracting solution；Filter obtain medicinal residues add relative to the determining alcohol of described medicinal residues quality 1～2 times be 85～
The ethanol of 95%, is heated to reflux 1～3 hour, extracts, and filters and obtains the second extracting solution；Extract first
Liquid and the second extracting solution merge, and concentrating under reduced pressure removes alcohol solvent, are dried, it is thus achieved that dry cream；
Second step, is placed in super micron mill pulverizing 1～2 hour by the dry cream that the first step obtains, and pulverizes,
Sieve, it is thus achieved that 300 mesh～the micropowders of 400 mesh；
3rd step, adds relative to its quality 2～the shallow lake of 4 times in the micropowders obtained by second step
Powder, mixing, it is thus achieved that powder.
Hereinafter use embodiment to describe embodiments of the present invention in detail, whereby how the present invention is applied
Technological means solves technical problem, and the process that realizes reaching technique effect can fully understand and real according to this
Execute.
Embodiment 1: oral solutions
Take suona horn flower 200g, monkey nanmu 200g, clear Fructus Solani melongenae 140g, Herba Schisandrae intermediae 100g, the root 280g that bleeds,
Redwood 100g, Herba Hoyae lancilimbae 160g, Fructus Tamarindi Indicae 200g, Flos Eragrostinis cilianensis 250g, Herba Poae Sphondylodis 150g, Herba centaurll altaici 200g,
Herba Violae Inconspicui 240g, Radix berchemiae lineatae 200g, grass 100g and Herba Polygoni Runcinati 220g.
Its preparation method comprises the following steps:
The first step, by suona horn flower, monkey nanmu, clear Fructus Solani melongenae, Herba Schisandrae intermediae, bleed root and redwood mixing, adds
Relative to the alcohol reflux that mixture 4 times amount determining alcohol is 60% 3 times, each 3 hours, filter,
Filtrate merges, and reclaims ethanol, and being concentrated into 70 DEG C of relative densities is the mastic of 1.31, standby；
Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 5 times amount water, boils
2 hours, filtering, being concentrated into 70 DEG C of relative densities is the mastic of 1.28；
3rd step, the described mastic mixing that the first step, second step are obtained, 65 DEG C of reduced vacuum are dried,
Get dry extract powder；
4th step, added ethanol in the described dried cream powder the 3rd step obtained, obtains containing alcohol mastic, described
The alcohol content of containing alcohol mastic is 70%；Described containing alcohol mastic is carried out successively chilling treatment, precipitation process,
Filtration treatment, recovery Ethanol Treatment, obtain dealcoholysis mastic, and wherein, the chilling treatment time is 35 hours,
Refrigerated storage temperature is 5 DEG C；
5th step, will in described dealcoholysis mastic add cane sugar powder, activated carbon, carry out successively heat treated,
Filtration treatment, dilution process, and obtain semi-finished product；Described dealcoholysis mastic with the weight ratio of described cane sugar powder is
1∶0.2；Described dealcoholysis mastic is 1: 0.001 with the weight ratio of described activated carbon；Described heat treated
Time is 30 minutes, and temperature is 100 DEG C；
6th step, then by the 5th step obtain described semi-finished product carry out successively filtration treatment, embedding process,
Sterilization treatment, obtains described Chinese medicine preparation oral liquid finished product.
Embodiment 2: powder
Take suona horn flower 240g, monkey nanmu 180g, clear Fructus Solani melongenae 170g, Herba Schisandrae intermediae 140g, the root 250g that bleeds,
Redwood 120g, Herba Hoyae lancilimbae 130g, Fructus Tamarindi Indicae 220g, Flos Eragrostinis cilianensis 210g, Herba Poae Sphondylodis 170g, Herba centaurll altaici 160g,
Herba Violae Inconspicui 260g, Radix berchemiae lineatae 180g, grass 140g and Herba Polygoni Runcinati 200g.
Its preparation method comprises the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, adds relative to mixture quality 4
The ethanol that determining alcohol is 95% again, is heated to reflux 1 hour, extracts, and filters and obtains the first extracting solution；
Filter the medicinal residues obtained and add the ethanol that determining alcohol is 85% relative to described medicinal residues quality 2 times, add
Hot reflux 3 hours, extracts, and filters and obtains the second extracting solution；First extracting solution and the second extracting solution are closed
And, concentrating under reduced pressure removes alcohol solvent, is dried, it is thus achieved that dry cream；
Second step, is placed in super micron mill pulverizing 1 hour by the dry cream that the first step obtains, and pulverizes,
Sieve, it is thus achieved that the micropowders of 300 mesh；
3rd step, adds the starch relative to its quality 3 times in the micropowders obtained by second step,
Mixing, it is thus achieved that powder.
Toxicity test:
Acute toxicity testing: application mice 60, male and female half and half, body weight 20-36g, carries out acute poison
Property test.Mice is randomly divided into two groups, i.e. matched group and administration group, fasting 12 hours before experiment, incite somebody to action this
The extract oral liquor of inventive embodiment 1 preparation is dissolved in water, (concentration is 8.54g crude drug/ml,
Maximum concentration) gavage, gavage volume is 5ml/kg (i.e. unit dosage form is 42.7 crude drugs/kg),
Matched group gives normal saline, within one day, is administered 2 times, delivery time 6 hours, connects after administration
Continuous observe 14 days, and record mice toxic reaction and death toll.Test result indicate that: with matched group
Relatively, after administration, mice has no notable difference, experiment Continuous Observation 14 days, mouse systemic situation, diet,
Drinking-water, body weight increase the most normal.Oral solutions LD50 > 42.7 crude drugs/the kg of the Mouse oral gavage present invention,
Every day, maximum dosage-feeding was 85.4 crude drugs/kg/ day.The Chinese medicine clinical application amount of the present invention is 8.65g crude drug
/ day/people, adult's body weight is in terms of 60KG, and average dosage is 0.144g crude drug/kg/ day.By body weight
Meter: the dosis tolerata of the Chinese medicine of mice (average weight is in terms of 28g) the oral administration gavage present invention is as quantity
593 times.Therefore the Chinese medicine acute toxicity of the present invention is extremely low, clinical drug safety.
Long term toxicity test: Chinese medicine embodiment 1 oral solutions of the present invention is to three groups of mices (often group 20)
By 13.24,25.46 and 42.37g crude drugs/kg continuous use 15 weeks (1.0ml/100g body weight, every day
2 times) and drug withdrawal 3 weeks after, result shows: Chinese medicine of the present invention to the hair of mice, behavior, defecation,
The indexs such as body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat all have no significant effect, internal organs
Naked eyes do not find that difference change and histological indications show, after medication 15 weeks and drug withdrawal 3 weeks, little
The each internal organs of Mus are all without substantially changing.Illustrate that Chinese medicine of the present invention is little, after drug withdrawal to toxicity after mice long-term prescription
There is no difference reaction, application safety yet.
Clinical data:
Case selection: all 100 example cases derive from this Out-patient Department and inpatient, male 47 examples, female
53 examples；Age 20-69 year；The course of disease 2 months-6 years.It is randomly divided into treatment group and matched group, wherein,
Treatment group 50 people, male 24 examples, female 26 example.Age 22-69 year；The course of disease 2 months-6 years.Comparison
Organize 50 people, male 23 examples, female 27 example.Age 20-68 year；The course of disease 2 months-5 years.Treatment group with
Matched group compares no significant difference at aspects such as sex, age, the course of disease and clinical symptoms, has comparability.
Diagnostic criteria: " clinical disease diagnosis and the curative effect judging standard " write with reference to hospital associate of Hunan Province
The diagnostic criteria of middle chronic appendicitis.
Therapeutic Method:
Matched group: take antiinflammatory, support, the mode of anti symptom treatment to treat.By ceftriaxone sodium 2g, add
Gentamycin 240,000 unit and first nitre file 1g proportioning, give patient intravenous drip, to without obvious heating
Patient infuses 1000-1500ml every day, and infuse every day 2000ml to the patient having substantially heating.Give simultaneously
Give oral vitamin C anti inflammatory detoxication, improve patient's body tolerance；Treatment 10 days continuously.
Treatment group: on the basis for the treatment of of control group, treatment group patient is administered orally Chinese medicine of the present invention simultaneously and implements
Example 1 oral solutions, each 20ml, three times a day；Treatment 10 days continuously.
Curative effect judging standard: (1) cures: Right Lower Abdomen pain disappears, tenderness and rebound tenderness are negative, appetite
The auxiliary examinations such as increasing, spirit is normal, weak without feeling, routine blood test all recover normal；(2) take a turn for the better: right
Hypogastralgia substantially alleviates；Time when making only, without tenderness and rebound tenderness, diet improves, spirit improvement, blood
The auxiliary examinations such as routine have improvement；(3) invalid: the symptoms such as Right Lower Abdomen pain are without improving or increasing the weight of.
Therapeutic outcome: after two groups are treated 10 days respectively, statistical result sees table 1.
Clinical efficacy comparison (unit: example) after treating 10 days respectively organized by 1 liang of table
| Group | Number of cases | Cure | Take a turn for the better | Invalid | Total effective rate |
| Treatment group | 50 | 35 | 13 | 2 | 48 (96%) |
| Matched group | 50 | 22 | 18 | 10 | 40 (80%) |
As it can be seen from table 1 treatment group uses the Chinese medicine of the present invention, coordinate western medical treatment chronic appendicitis,
Relative to matched group, on therapeutic effect, have and be markedly improved.
, all there is not hepatic and renal function injure or other is the worst in untoward reaction: during two groups of patient treatments
Reaction.
Concrete case: high certain, female, 52 years old, private prosecution was made a definite diagnosis in other hospitals and is suffered from chronic appendicitis existing 3
Year, therapeutic effect is bad, multiple relapse.Recently induce because of improper diet, see a doctor to the court.Through facing
Bed symptom and auxiliary examination are diagnosed as chronic appendicitis.Take the doctor trained in Western medicine conventional treatment of matched group, with
Time the oral solutions of inventive embodiments 1 be administered orally, each 20ml, three times a day, after treating 10 days, right
Hypogastralgia disappears, and tenderness and rebound tenderness are negative, and appetite increases, and spirit is normal, and weak without feeling, blood is normal
The auxiliary examinations such as rule are normal, cure, and follow up a case by regular visits to 6 months without recurrence.
All above-mentioned primary implement these intellectual properties, do not set limit other forms enforcement this
Plant new product or new method.Those skilled in the art will utilize this important information, and foregoing is revised,
To realize similar implementation status.But, all modifications or transformation belong to reservation based on new product of the present invention
Right.
The above, be only presently preferred embodiments of the present invention, is not that the present invention makees other form
Restriction, any those skilled in the art are changed possibly also with the technology contents of the disclosure above
Or it is modified as the Equivalent embodiments of equivalent variations.But every without departing from technical solution of the present invention content, depend on
Any simple modification, equivalent variations and remodeling above example made according to the technical spirit of the present invention,
Still fall within the protection domain of technical solution of the present invention.
Claims (9)
1. the Chinese medicine preparation treating chronic appendicitis, it is characterised in that described Chinese medicine preparation includes
Following raw medicinal material: suona horn flower, monkey nanmu, clear Fructus Solani melongenae, Herba Schisandrae intermediae, root of bleeding, redwood, Herba Hoyae lancilimbae,
Fructus Tamarindi Indicae, Flos Eragrostinis cilianensis, Herba Poae Sphondylodis, Herba centaurll altaici, Herba Violae Inconspicui, Radix berchemiae lineatae, grass and Herba Polygoni Runcinati.
2. Chinese medicine preparation as claimed in claim 1, it is characterised in that the weight portion of described raw medicinal material
Number ratios be: suona horn spend 20～30 parts, monkey nanmu 15～25 parts, clear Fructus Solani melongenae 10～20 parts, Herba Schisandrae intermediae 10～
20 parts, bleed root 20～30 parts, redwood 5～15 parts, Herba Hoyae lancilimbae 10～20 parts, Fructus Tamarindi Indicae 15～25
Part, Flos Eragrostinis cilianensis 20～30 parts, Herba Poae Sphondylodis 10～20 parts, Herba centaurll altaici 12～22 parts, Herba Violae Inconspicui 20～30
Part, Radix berchemiae lineatae 15～25 parts, grass 10～20 parts and Herba Polygoni Runcinati 15～25 parts.
3. Chinese medicine preparation as claimed in claim 1 or 2, it is characterised in that the weight of described raw medicinal material
Amount portion rate is: suona horn spends 20～25 parts, monkey nanmu 17～22 parts, clear Fructus Solani melongenae 13～18 parts, Herba Schisandrae intermediae
10～15 parts, bleed root 25～30 parts, redwood 8～13 parts, Herba Hoyae lancilimbae 12～17 parts, Fructus Tamarindi Indicae 18～
23 parts, Flos Eragrostinis cilianensis 20～25 parts, Herba Poae Sphondylodis 13～18 parts, Herba centaurll altaici 15～20 parts, Herba Violae Inconspicui 22～
27 parts, Radix berchemiae lineatae 17～22 parts, grass 10～15 parts and Herba Polygoni Runcinati 18～23 parts.
4. the Chinese medicine preparation as described in claims 1 to 3, it is characterised in that the weight of described raw medicinal material
Amount portion rate is: suona horn is spent 24 parts, monkey nanmu 18 parts, clear Fructus Solani melongenae 17 parts, Herba Schisandrae intermediae 14 parts, bled
Root 25 parts, redwood 12 parts, Herba Hoyae lancilimbae 13 parts, Fructus Tamarindi Indicae 22 parts, Flos Eragrostinis cilianensis 21 parts, Herba Poae Sphondylodis
17 parts, Herba centaurll altaici 16 parts, Herba Violae Inconspicui 26 parts, Radix berchemiae lineatae 18 parts, grass 14 parts and Herba Polygoni Runcinati 20 parts.
5. the Chinese medicine preparation as described in Claims 1-4, it is characterised in that the weight of described raw medicinal material
Amount portion rate is: suona horn is spent 20 parts, monkey nanmu 20 parts, clear Fructus Solani melongenae 14 parts, Herba Schisandrae intermediae 10 parts, bled
Root 28 parts, redwood 10 parts, Herba Hoyae lancilimbae 16 parts, Fructus Tamarindi Indicae 20 parts, Flos Eragrostinis cilianensis 25 parts, Herba Poae Sphondylodis
15 parts, Herba centaurll altaici 20 parts, Herba Violae Inconspicui 24 parts, Radix berchemiae lineatae 20 parts, grass 10 parts and Herba Polygoni Runcinati 22 parts.
6. the Chinese medicine preparation as described in claim 1 to 5, it is characterised in that the agent of described Chinese medicine preparation
Type is oral solutions, and its preparation method comprises the following steps:
The first step, by suona horn flower, monkey nanmu, clear Fructus Solani melongenae, Herba Schisandrae intermediae, bleed root and redwood mixing, adds
Relative to 3 times of mixture～alcohol reflux that 5 times amount determining alcohols are 55%～65% 2 times～4 times,
Each 2 hours～3 hours, filtering, filtrate merges, and reclaims ethanol, and being concentrated into 70 DEG C of relative densities is
The mastic of 1.30～1.32, standby；
Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 3～5 times amount water, boils
Boil 2～4 hours, filter, be concentrated into the mastic that 70 DEG C of relative densities are 1.27～1.29；
3rd step, the described mastic mixing that the first step, second step are obtained, 55 DEG C～65 DEG C of reduced vacuum
Being dried, get dry extract powder；
4th step, added ethanol in the described dried cream powder the 3rd step obtained, obtains containing alcohol mastic, described
The alcohol content of containing alcohol mastic is 65%～70%；Described containing alcohol mastic is carried out chilling treatment, precipitation successively
Process, filtration treatment, recovery Ethanol Treatment, obtain dealcoholysis mastic, wherein, the chilling treatment time be 30～
40 hours, refrigerated storage temperature was 2 DEG C～6 DEG C；
5th step, will in described dealcoholysis mastic add cane sugar powder, activated carbon, carry out successively heat treated,
Filtration treatment, dilution process, and obtain semi-finished product；Described dealcoholysis mastic with the weight ratio of described cane sugar powder is
1: 0.1～0.3；Described dealcoholysis mastic is 1: 0.001～0.002 with the weight ratio of described activated carbon；Institute
The time stating heat treated is 20～40 minutes, and temperature is 100 DEG C～110 DEG C；
6th step, then by the 5th step obtain described semi-finished product carry out successively filtration treatment, embedding process,
Sterilization treatment, obtains described Chinese medicine preparation oral liquid finished product.
7. the Chinese medicine preparation as described in claim 1 to 5, it is characterised in that the agent of described Chinese medicine preparation
Type is powder, and its preparation method comprises the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, add relative to mixture quality 2～
The determining alcohol of 4 times is the ethanol of 85～95%, is heated to reflux 1～3 hour, extracts, and filters acquisition first
Extracting solution；Filter obtain medicinal residues add relative to the determining alcohol of described medicinal residues quality 1～2 times be 85～
The ethanol of 95%, is heated to reflux 1～3 hour, extracts, and filters and obtains the second extracting solution；Extract first
Liquid and the second extracting solution merge, and concentrating under reduced pressure removes alcohol solvent, are dried, it is thus achieved that dry cream；
Second step, is placed in super micron mill pulverizing 1～2 hour by the dry cream that the first step obtains, and pulverizes,
Sieve, it is thus achieved that 300 mesh～the micropowders of 400 mesh；
3rd step, adds relative to its quality 2～the shallow lake of 4 times in the micropowders obtained by second step
Powder, mixing, it is thus achieved that powder.
8. the preparation method of the Chinese medicine preparation described in a claim 1 to 5, it is characterised in that described
The dosage form of Chinese medicine preparation is oral solutions, and it comprises the following steps:
The first step, by suona horn flower, monkey nanmu, clear Fructus Solani melongenae, Herba Schisandrae intermediae, bleed root and redwood mixing, adds
Relative to 3 times of mixture～alcohol reflux that 5 times amount determining alcohols are 55%～65% 2 times～4 times,
Each 2 hours～3 hours, filtering, filtrate merges, and reclaims ethanol, and being concentrated into 70 DEG C of relative densities is
The mastic of 1.30～1.32, standby；
Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 3～5 times amount water, boils
Boil 2～4 hours, filter, be concentrated into the mastic that 70 DEG C of relative densities are 1.27～1.29；
3rd step, the described mastic mixing that the first step, second step are obtained, 55 DEG C～65 DEG C of reduced vacuum
Being dried, get dry extract powder；
4th step, added ethanol in the described dried cream powder the 3rd step obtained, obtains containing alcohol mastic, described
The alcohol content of containing alcohol mastic is 65%～70%；Described containing alcohol mastic is carried out chilling treatment, precipitation successively
Process, filtration treatment, recovery Ethanol Treatment, obtain dealcoholysis mastic, wherein, the chilling treatment time be 30～
40 hours, refrigerated storage temperature was 2 DEG C～6 DEG C；
5th step, will in described dealcoholysis mastic add cane sugar powder, activated carbon, carry out successively heat treated,
Filtration treatment, dilution process, and obtain semi-finished product；Described dealcoholysis mastic with the weight ratio of described cane sugar powder is
1: 0.1～0.3；Described dealcoholysis mastic is 1: 0.001～0.002 with the weight ratio of described activated carbon；Institute
The time stating heat treated is 20～40 minutes, and temperature is 100 DEG C～110 DEG C；
6th step, then by the 5th step obtain described semi-finished product carry out successively filtration treatment, embedding process,
Sterilization treatment, obtains described Chinese medicine preparation oral liquid finished product.
9. the preparation method of the Chinese medicine preparation described in a claim 1 to 5, it is characterised in that described
The dosage form of Chinese medicine preparation is powder, and its preparation method comprises the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, add relative to mixture quality 2～
The determining alcohol of 4 times is the ethanol of 85～95%, is heated to reflux 1～3 hour, extracts, and filters acquisition first
Extracting solution；Filter obtain medicinal residues add relative to the determining alcohol of described medicinal residues quality 1～2 times be 85～
The ethanol of 95%, is heated to reflux 1～3 hour, extracts, and filters and obtains the second extracting solution；Extract first
Liquid and the second extracting solution merge, and concentrating under reduced pressure removes alcohol solvent, are dried, it is thus achieved that dry cream；
Second step, is placed in super micron mill pulverizing 1～2 hour by the dry cream that the first step obtains, and pulverizes,
Sieve, it is thus achieved that 300 mesh～the micropowders of 400 mesh；
3rd step, adds relative to its quality 2～the shallow lake of 4 times in the micropowders obtained by second step
Powder, mixing, it is thus achieved that powder.
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| CN105106783A (en) * | 2015-09-07 | 2015-12-02 | 江淑芬 | Traditional Chinese medicine composition for treating chronic appendicitis and application thereof |
| CN105362583A (en) * | 2015-11-28 | 2016-03-02 | 孙继玲 | Traditional Chinese medicine preparation for treating chronic appendicitis and preparation method thereof |
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| CN105362583A (en) * | 2015-11-28 | 2016-03-02 | 孙继玲 | Traditional Chinese medicine preparation for treating chronic appendicitis and preparation method thereof |
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Application publication date: 20160907 |