CN105362583A - Traditional Chinese medicine preparation for treating chronic appendicitis and preparation method thereof - Google Patents
Traditional Chinese medicine preparation for treating chronic appendicitis and preparation method thereof Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicine preparation for treating chronic appendicitis and a preparation method thereof. The traditional Chinese medicine preparation comprises Sonchus brachyotus, Indian strawberry, Polygonum multiflorum, Ixeris polycephala, southern gentian, rhizome of Peltate yam, Patrinia rupestris, Artemisia rupestris, Loropetalum leaf, Trollius macropetalus, Hedyotis tenelliflora, Bidens biternata, ching's briggsia, Rhizoma homalomenae, Rhizoma arisaematis, Radix clematidis, Cortex erythrinae, Dryopteris sophoroides and Fructus arctii. The traditional Chinese medicine preparation has the beneficial effects of safety and convenience in use, good treatment effect, freeness of toxic and side effect, quick action and simple preparation process.
Description
Technical field
The present invention relates to engineering of traditional Chinese medicine technical field, particularly relate to a kind of Chinese medicine preparation for the treatment of chronic appendicitis and preparation method thereof.
Background technology
Chronic appendicitis is frequently-occurring disease common clinically, is the vermiform appendix chronic inflammatory conditions because leaving over after vermiform appendix acute inflammation subsides, and as tube wall fibre structure hamartoplasia, luminal stenosis or obturation, torsion of appendix, with surrounding structure tissue adhesion etc.Show as right lower abdomen pain clinical, body temperature raises more, the performances such as vomiting and neutrophilic leukocytosis.Doctor trained in Western medicine is mainly based on operation, and coordinate anti-inflammatory treatment, the traditional Chinese medical science thinks that this disease belongs to " acute appendicitis " category, mostly uses Chinese medical discrimination to treat.
Acute appendicitis is that pyretic toxicity is cohesion, in stasis intestinal, and a kind of disease of raw pus of carbuncle.Clinical in fever with chills, swelling and oppresive sensation of the lower abdomen.Pain contracture is feature.Primary disease many by feed savoury, addiction to uncooked and cold food and eating and drinking too much at one meal etc. because of so that taste are impaired, and gastrointestinal development of evil in febrile disease function is unfavorable, and mechanism of qi is jammed and forms; Or cruelly run because of anxious on a full stomach, or tumbling down damage, cause intestinal internal organs injury of small vessels, blood stasis stagnates, and the heat-transformation of intestinal internal organs, stagnation of blood stasis and heat, causes blood to lose meat corruption and form pus of carbuncle." Waike Zhengzong, Orthodox Manual of External Diseases " rolls up three: " acute appendicitis person, all damp and hot blood stasis stream forms also in small intestinal.Origin has three: man cruelly suddenly runs, so that the intestines and stomach transmission can not Shu Li, and deteriorated blood foul smell is stopped up and held back the person of forming also; Married woman puerperal, the empty drowsiness of body, sits without rising, again or confinement in childbirth (tire products) difficult, exert oneself too, educate rear mistake by losing the stasis of blood, so that deteriorated blood stopping long-pending the intestines and stomach, tying the stagnant person of forming two also; Hungry full impairment caused by overstrain, undertakes weight, the intestines and stomach of causing injury, and again or liquor-saturated full exhaustion due to sexual indulgence, cross and hinder energy, or raw food is gone forward side by side, the coagulation of QI-blood person of forming three also." eating and drinking without temperance, eating and drinking too much at one meal, or the thing that surfeit is greasy, raw and cold, unclean, damage the intestines and stomach, retention of damp-heat in the interior is between intestinal; Or because sharply running after diet, causing qi depression to blood stasis, intestinal network is impaired; Or because of cold temperature discomfort, tumbling down damages, Nervous and Mental Factors etc., causes the stagnation of QI, blood stasis, dampness, heat is stopped up, the stasis of blood is stagnant, accumulated heat is not fallen apart, and blood slough loses and forms carbuncle.Modern medicine is thought, it is the principal pathogenetic reason of primary disease that vermiform appendix chamber is blocked with bacteriological infection.About the treatment of acute appendicitis, " Medical Treasures of the Golden Chamber " has and carries: " acute appendicitis person, swelling and oppresive sensation of the lower abdomen, i.e. the pain of pressing, as drenched, normal urination, fever occurring frequently, from sweating, aversion to cold again, the tight person's pus of its slow pulse does not become, can purgation, when there being blood; Full and rapid pulse person, formed pus, purgative being prohibited also, Dahuang Mudan skin soup master it ".
Summary of the invention
Technical problem to be solved by this invention is, utilizes the theory of Chinese medical science that China is traditional, provides a kind of determined curative effect and Chinese medicine preparation of the little treatment chronic appendicitis of toxic action and preparation method thereof.
In order to solve the problems of the technologies described above, the invention provides a kind of Chinese medicine preparation for the treatment of chronic appendicitis, described Chinese medicine preparation comprises following raw medicinal material: Herba Sonchi Arvensis, Herba Duchesneae Indicae, Radix Polygoni Multiflori, Herba Ixeritis polycephalae, Radix Gentianae Herba Violae, Dioscorea zingiberensis C. H. Wright, Herba Patriniae Rupestris, Herba Achilleae, Folium Loropetali, longpetal globeflower flower, stone maple medicine, Herba Bidentis Bipinnate (Herba Bidentis Pilosae, Herba Bidentis Pilosae), Herba Briggsiae Chienii, Rhizoma Homalomenae, Rhizoma Arisaematis, Radix Clematidis, Cortex erythrinae, Phymatopsis griffithiana (Hook.) J. Sm. and Fructus Arctii.
The ratio of weight and number of the various raw medicinal materials in described Chinese medicine preparation can be preferably: Herba Sonchi Arvensis 10 ~ 25 parts, Herba Duchesneae Indicae 15 ~ 25 parts, Radix Polygoni Multiflori 10 ~ 30 parts, Herba Ixeritis polycephalae 10 ~ 25 parts, Radix Gentianae Herba Violae 15 ~ 30 parts, Dioscorea zingiberensis C. H. Wright 10 ~ 25 parts, Herba Patriniae Rupestris 10 ~ 30 parts, Herba Achilleae 20 ~ 30 parts, Folium Loropetali 15 ~ 25 parts, longpetal globeflower flower 10 ~ 20 parts, stone maple medicine 20 ~ 35 parts, Herba Bidentis Bipinnate (Herba Bidentis Pilosae, Herba Bidentis Pilosae) 15 ~ 30 parts, Herba Briggsiae Chienii 10 ~ 30 parts, Rhizoma Homalomenae 10 ~ 25 parts, Rhizoma Arisaematis 10 ~ 25 parts, Radix Clematidis 10 ~ 20 parts, Cortex erythrinae 10 ~ 30 parts, Phymatopsis griffithiana (Hook.) J. Sm. 15 ~ 25 parts and Fructus Arctii 10 ~ 25 parts.
The ratio of weight and number of the various raw medicinal materials in described Chinese medicine preparation can also more preferably: Herba Sonchi Arvensis 10 ~ 15 parts, Herba Duchesneae Indicae 20 ~ 25 parts, Radix Polygoni Multiflori 15 ~ 25 parts, Herba Ixeritis polycephalae 15 ~ 25 parts, Radix Gentianae Herba Violae 20 ~ 25 parts, Dioscorea zingiberensis C. H. Wright 15 ~ 20 parts, Herba Patriniae Rupestris 20 ~ 30 parts, Herba Achilleae 25 ~ 30 parts, Folium Loropetali 15 ~ 20 parts, longpetal globeflower flower 10 ~ 15 parts, stone maple medicine 25 ~ 35 parts, Herba Bidentis Bipinnate (Herba Bidentis Pilosae, Herba Bidentis Pilosae) 20 ~ 30 parts, Herba Briggsiae Chienii 15 ~ 25 parts, Rhizoma Homalomenae 10 ~ 15 parts, Rhizoma Arisaematis 15 ~ 20 parts, Radix Clematidis 15 ~ 20 parts, Cortex erythrinae 20 ~ 30 parts, Phymatopsis griffithiana (Hook.) J. Sm. 20 ~ 25 parts and Fructus Arctii 15 ~ 25 parts.
The ratio of weight and number of the various raw medicinal materials in described Chinese medicine preparation also can more preferably: Herba Sonchi Arvensis 13 parts, Herba Duchesneae Indicae 23 parts, Radix Polygoni Multiflori 20 parts, Herba Ixeritis polycephalae 21 parts, Radix Gentianae Herba Violae 22 parts, Dioscorea zingiberensis C. H. Wright 18 parts, Herba Patriniae Rupestris 25 parts, Herba Achilleae 26 parts, Folium Loropetali 18 parts, longpetal globeflower flower 15 parts, stone maple medicine 27 parts, Herba Bidentis Bipinnate (Herba Bidentis Pilosae, Herba Bidentis Pilosae) 25 parts, Herba Briggsiae Chienii 23 parts, Rhizoma Homalomenae 13 parts, Rhizoma Arisaematis 18 parts, Radix Clematidis 16 parts, Cortex erythrinae 25 parts, Phymatopsis griffithiana (Hook.) J. Sm. 22 parts and Fructus Arctii 20 parts.
When the dosage form of described Chinese medicine preparation is granule, its preparation method comprises the following steps:
Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 5 ~ 6 times, mixture is the ethanol of 80% ~ 95%, be heated to boiling reflux 4 ~ 6 hours, filter, take backflow as solvent, take filtering residue as solute, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.08Mpa, relative density is the mastic of 1.05 ~ 1.10, spraying dry, the inlet temperature of spray dryer 160 ~ 175 DEG C, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder,
Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 ~ 0.4 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes granule, in 40 ~ 50 DEG C of dryings, obtains granule.
When the dosage form of described Chinese medicine preparation is capsule, its preparation method comprises the following steps:
The first step, Herba Sonchi Arvensis, Herba Duchesneae Indicae, Radix Polygoni Multiflori, Herba Ixeritis polycephalae, Radix Gentianae Herba Violae and Dioscorea zingiberensis C. H. Wright are mixed in described ratio, add the water extraction volatile oil relative to 4 ~ 6 times, mixture, by the volatile oil beta-cyclodextrin inclusion compound obtained, the ratio of volatile oil and beta-schardinger dextrin-is 1: 3 ~ 6, stirs 75 minutes ~ 90 minutes, temperature 30 DEG C ~ 50 DEG C, obtain volatile oil clathrate compound, for subsequent use; Another when aqueous extract being concentrated into 60 DEG C relative density be the clear paste of 1.15 ~ 1.17;
Second step, Folium Loropetali, longpetal globeflower flower, stone maple medicine, Herba Briggsiae Chienii, Rhizoma Homalomenae, Rhizoma Arisaematis and Cortex erythrinae are mixed in described ratio, add relative to mixture 6 ~ 8 times amount determining alcohol be 80% ~ 90% alcohol reflux 3 ~ 5 times, each 2 ~ 3 hours, filter, filtrate merges, and reclaims ethanol, when being concentrated into 60 DEG C, relative density is the clear paste of 1.20 ~ 1.22, for subsequent use;
3rd step, will remain described raw medicinal material and mix in described ratio, add relative to mixture 8 ~ 10 times of water gagings, boil 6 ~ 8 hours, filter, and when being concentrated into 65 DEG C, relative density is the clear paste of 1.28 ~ 1.30;
4th step, mixed by the clear paste of the first step, second step, the 3rd step, 60 DEG C ~ 70 DEG C reduced vacuum dryings, get dry extract powder;
5th step, dried cream powder described in volatile oil clathrate compound described in the first step and the 4th step is fully mixed, add the mixture relative to volatile oil clathrate compound described in 100 weight portions and dried cream powder subsequently, 5 ~ 8 weight portion carboxymethyl starch sodium, 10 ~ 50 weight starch mix homogeneously, adding 150 ~ 200 weight portion determining alcohols is 80% ~ 90% alcohol granulation, dry, granulate, add the mixture relative to volatile oil clathrate compound described in 100 weight portions and dried cream powder subsequently, 3 ~ 5 weight portion magnesium stearate, then load in gelatine capsule.
Beneficial effect of the present invention: the Chinese medicine preparation that chronic appendicitis of the present invention uses is safe and convenient to use, and therapeutic effect is good, has no side effect, instant effect, and preparation technology is simple.
Detailed description of the invention
The invention provides a kind of Chinese medicine preparation for the treatment of chronic appendicitis, Chinese medicine preparation comprises following raw medicinal material: Herba Sonchi Arvensis, Herba Duchesneae Indicae, Radix Polygoni Multiflori, Herba Ixeritis polycephalae, Radix Gentianae Herba Violae, Dioscorea zingiberensis C. H. Wright, Herba Patriniae Rupestris, Herba Achilleae, Folium Loropetali, longpetal globeflower flower, stone maple medicine, Herba Bidentis Bipinnate (Herba Bidentis Pilosae, Herba Bidentis Pilosae), Herba Briggsiae Chienii, Rhizoma Homalomenae, Rhizoma Arisaematis, Radix Clematidis, Cortex erythrinae, Phymatopsis griffithiana (Hook.) J. Sm. and Fructus Arctii.
The pharmacology of various raw medicinal material is as follows:
Herba Sonchi Arvensis: [source] medical material Ji Yuan: for feverfew is crawled the herb of stem Herba Sonchi Oleracei.[nature and flavor] bitter in the mouth; Cold in nature.[function cures mainly] heat-clearing and toxic substances removing; Promoting diuresis and pus discharge; Cooling blood for hemostasis.Main laryngopharynx swelling and pain; Furuncle toxic swelling; Hemorrhoid; Acute bacillary dysentery; Intestinal is scorching; Lung abscess; Acute appendicitis; Leaf blood; Epistaxis ' spitting of blood; Hematuria; Have blood in stool; Metrorrhagia.[each discussion] 1. " Hebei Chinese medicine handbook ": heat-clearing and toxic substances removing.Control acute bacillary dysentery, acute laryngitis, internal hemorrhoid is deviate from.2. " the common identification obscuring Chinese herbal medicine ": control leucorrhea and postnatal blood stasis stomachache, appendicitis.[extracts] " China's book on Chinese herbal medicine "
Herba Duchesneae Indicae: [source] medical material Ji Yuan: be the herb of rosaceous plant Herba Duchesneae Indicae.[nature and flavor] are sweet, bitter; Cold .[return through] lung; Liver; Large intestine channel.[function cures mainly] heat-clearing and toxic substances removing; Dissipating blood stasis Xiao swells; Cooling blood for hemostasis.Main calentura; Infantile convulsion; Cough; Spit blood; Laryngopharynx swelling and pain; Dysentery; Carbuncle; Furuncle; Snake bite and insect sting; Scald; Flu; Jaundice; Conjunctival congestion; Aphtha; Mumps; Furuncle and phyma; Metrorrhagia; Menoxenia; Treating swelling and pain by traumatic injury.[extracts] " China's book on Chinese herbal medicine "
Radix Polygoni Multiflori: [source] medical material Ji Yuan: be the tuber of polygonum multiflorum thunb.[nature and flavor] are bitter; Sweet; Puckery; Slightly warm in nature.[return through] liver; Kidney channel.[function cures mainly] nourishing the blood and yin; Loosening bowel to relieve constipation; Preventing the attack (or recurrence) of malaria; Dispel the wind; Removing toxic substances.Main blood deficiency Light-headedness; Cardiopalmus; Insomnia; The soreness of the waist and knees of the hepatic and renal YIN deficiency; Early whitening of beard and hair; Tinnitus; Seminal emission; Dryness of the intestine constipation; Chronic malaria body is empty; Rubella pruritus; Carbuncle sore; Scrofula; Hemorrhoid.[extracts] " China's book on Chinese herbal medicine "
Herba Ixeritis polycephalae: [another name] Herba crotalariae albidae, Hemerocallis citrina Baroni mountain Herba monochoriae vaginalis, Herba clinopodii confinis (Herba Clinopodii Gracilis), scissors stock, Herba Hylothelephii Verticillati.[source] medical material Ji Yuan: be the herb of feverfew many passes gutweed.[nature and flavor] bitter in the mouth; Sweet; Cool in nature.[function cures mainly] heat clearing away; Removing toxic substances; Dampness removing.Main pharyngalgia; Conjunctival congestion and swelling pain; Appendicitis; Furuncle swelling toxin.[each discussion] " Xinhua's book on Chinese herbal medicine outline " herb: for laryngalgia, stomachache, rubella, appendicitis.Outer for innominate toxic swelling, acute mastitis.[extracts] " China's book on Chinese herbal medicine "
Radix Gentianae Herba Violae: [another name] Herba Violae, Herba Violae, Haiti fourth, little Jin melon pipe, soil lotus, see lotus, bluet, soil fourth.[source] medical material Ji Yuan: be the whole herb with root of gentianaceae plant Gentiana.[nature and flavor] are bitter; Cold in nature.[function cures mainly] clearing away heat-damp and promoting diuresis; Removing toxicity for eliminating carbuncles.Main hepatitis; Dysentery; Fever of children; Laryngopharynx swelling and pain; Leucorrhea; Hematuria; Appendicitis; Sore swollen toxin; Tuberculous lymphadenitis.[extracts] " China's book on Chinese herbal medicine "
Dioscorea zingiberensis C. H. Wright: [another name] medicated pillow root, Dioscorea zingiberensis, Rhizoma Coptidis ginseng, Dioscorea zingiberensis, Rhizoma Colocasiae antiquori Rhizoma Zingiberis Recens.[source] medical material Ji Yuan: be the rhizome of Dioscoreaceae plant Rhizoma Dioscoreae Zingiberensis.[nature and flavor] bitter in the mouth; Micro-sweet; Cool in nature; Mild toxicity.[function cures mainly] clearing away lung-heat to relieve cough; Dampness removing is treating stranguria; Removing obstruction in the collateral to relieve pain; Removing toxic substances and promoting subsidence of swelling.Main cough due to lung-heat; Damp and hot pouring pain; Lumbago due to pathogenic wind-dampness; Carbuncle malignant boil; Osteopatia sprain; Honeybee stings insect bite.[each discussion] " full exhibition a collection of selected materials surgery ": control carbuncle furuncle early end of term ulceration, honeybee stings, appendicitis.[extracts] " China's book on Chinese herbal medicine "
Herba Patriniae Rupestris: [source] medical material Ji Yuan: be the herb of Valerianaceae plant Herba Patriniae Rupestris.[nature and flavor] acrid in the mouth; Bitter; Cold in nature.[function cures mainly] heat-clearing and toxic substances removing; Invigorate blood circulation; Evacuation of pus.Main dysentery; Have loose bowels; Jaundice; Enterodynia.[extracts] " China's book on Chinese herbal medicine "
Herba Achilleae: [another name] Artemisia rupestris L., Cornu Cervi Artemisia.[source] medical material Ji Yuan: be the herb of feverfew Herba Artemisiae Brachylobae.[nature and flavor] acrid in the mouth; Micro-hardship; Property micro-wet.[function cures mainly] expelling pathogenic wind from the body surface; Stomach invigorating removing food stagnancy; Promoting blood circulation to remove blood stasis.Main anemofrigid cold; Stagnation of QI due to dyspepsia; Abdominal distention; Traumatic injury congestive edema; Rubella; Snakebite.[each discussion] 1. " detailed outline ": Millefolium leaf cures mainly painful abdominal mass disease.2. " detailed outline is picked up any lost article from the road ": promoting blood circulation and detoxication, go the diseases such as all are stagnant, severe and lingering illness or habit YIN-cold, wind dispelling reason is timid.3. " classify herbal " and control all pyretic toxicity, be coated with skin ulcer granulation promoting.4. be " will planted by northeast medicine ": be stomach invigorating, analeptic, again hemorrhoid medicine.[extracts] " China's book on Chinese herbal medicine "
Folium Loropetali: [another name] Folium Loropetali.[source] medical material Ji Yuan: be the leaf of Hamamelidaceae Plants Loropetalum chinense (R. Br.) Oliv..[nature and flavor] bitter in the mouth; Puckery; Cool in nature.[return through] liver; Stomach; Large intestine channel.[function cures mainly] astringing to arrest bleeding; Heat-clearing and toxic substances removing.Main spitting of blood; Spit blood; Have blood in stool; Metrorrhagia; Post partum longtime lochia; Purpura; Summer-heat dysentery; Traumatic injury; Wound hemorrhage; Liver-heat conjunctival congestion; Laryngalgia.[extracts] " China's book on Chinese herbal medicine "
Longpetal globeflower flower: [source] medical material Ji Yuan: be the flower of ranunculaceae plant longpetal globeflower flower.[nature and flavor] bitter in the mouth; Cold in nature.[return through] lung meridian.[function cures mainly] heat-clearing and toxic substances removing.Your Majesty's respiratory tract infection; Acute and chronic tonsillitis; Acute conjunctivitis; Acute otitis media; Acute lymphoblastic is scorching; Acute dysentery; Acute appendicitis.[extracts] " China's book on Chinese herbal medicine "
Stone maple medicine: [source] medical material Ji Yuan: be the herb of Maguireothamnus speciosus hedyotis tenelliflora Blume.[nature and flavor] micro-hardship; Flat; Cold.[function cures mainly] heat-clearing and toxic substances removing; Promoting blood circulation and stopping pain.Main cough due to lung-heat; Chronic hepatitis; Expand; Appendicitis; Dysentery; Acute toothache; Infantile hernia; Traumatic injury; Venom.[extracts] " China's book on Chinese herbal medicine "
Herba Bidentis Bipinnate (Herba Bidentis Pilosae, Herba Bidentis Pilosae): [another name] ferrum brush for cleaning pots and pans, thousand pins, the silver-colored small cups of gold dish.[source] medical material Ji Yuan: be the herb of section of district plant Herba Bidentis Bipinnate (Herba Bidentis Pilosae, Herba Bidentis Pilosae).[nature and flavor] sweet in the mouth; Micro-hardship; Cool in nature.[function cures mainly] heat-clearing and toxic substances removing; Cooling blood for hemostasis.Main cold, fever; Jaundice; Have loose bowels; Dysentery; Heat in blood is spitted blood; Metrorrhagia; Traumatic injury; Carbuncle sore tumefacting virus; The arthroncus of knee; Mange.[extracts] " China's book on Chinese herbal medicine "
Herba Briggsiae Chienii: [another name] East China Buddhist, tripe lettuce tongue, rock green vegetable, Fossilia Spiriferis Radix Notoginseng, Herba Melicae Scabrosae, Budgerigar, Rhizoma Seu Herba Bergeniae, little lotus grass.[source] medical material Ji Yuan: be root or the herb of Anhui, Gesneriaceae Zhejiang thick cylinder lettuce tongue.[nature and flavor] mildly bitter flavor; Property is put down.[function cures mainly] expelling pathogenic wind from the body surface; To invigorate blood circulation eliminating carbuncle.Main headache due to common cold; Impairment caused by overstrain; Muscles and bones is ached; Carbuncle skin ulcer; Innominate toxic swelling.[extracts] " China's book on Chinese herbal medicine "
Rhizoma Homalomenae: [another name] Rhizoma Homalomenae, Rhizoma Homalomenae, thousand pins, silk crest lines.[source] medical material Ji Yuan: be the rhizome of aroid Rhizoma Homalomenae.[nature and flavor] bitter in the mouth; Pungent; Warm in nature; Mild toxicity.[return through] liver; Kidney; Stomach warp.[function cures mainly] wind-damp dispelling; Relaxing muscles and tendons and activating QI and blood in the collateral; Pain relieving; Detumescence.Main air pain of dampness syndrome; Podomere acid is educated; Muscles and bones flaccidity is soft; Traumatic injury; Stomachache; Carbuncle skin ulcer swells.[extracts] " China's book on Chinese herbal medicine "
Rhizoma Arisaematis: [source] medical material Ji Yuan: be the tuber of the aroid tiger palm, Rhizoma Arisaematis, Rhizoma Arisaematis Rhizoma Arisaematis and arisaema amurense Maxim.[nature and flavor] bitter in the mouth; Pungent; Warm in nature.[return through] lung; Liver; Spleen channel.[function cures mainly] expellings wind and relieving convulsion; Dissipating phlegm and resolving masses.In master, wind-phlegm is stopped up; Mouth eye is arbitrarily askew; Hemiplegia; Paralysis of the limbs; Dizziness due to wind-phlegm; The insane spare time; Infantile convulsion; Tetanus; Cough ant phlegm; Carbuncle; Scrofula; Traumatic injury is benumbed; Venom.[each discussion] " Kaibao Bencao ": main apoplexy, expectorant, paralysis, the therapeutic method to keep the adverse QI flowing downwards, broken hard long-pending, subduing inflammation, sharp chest and diaphragm, loose blood induced abortion.[extracts] " China's book on Chinese herbal medicine "
Radix Clematidis: [another name] can disappear, radix smilacis sieboldi, Radix Clematidis, black foot Radix Clematidis, Caulis et Radix Periplocae Forrestii.[source] medical material Ji Yuan: be the root and rhizome of cohosh Radix Clematidis, Clematis hexapetala, Herba polygoni hydropiperis Radix clematidis floridae, hair post iron wire and post fruit Radix clematidis floridae.[nature and flavor] acrid in the mouth; Salty; Micro-hardship; Warm in nature; Mild toxicity.[return through] returns bladder; Liver Channel.[function cures mainly] expelling wind and removing dampness; Removing obstruction in the collateral to relieve pain.Cure mainly rheumatic arthralgia; Numb limbs and tense tendons; The contracture of muscle arteries and veins; Joint stuffiness; Beriberi swells and ache; Malaria; Bone is choked with sobs larynx; And control phlegm retention and gather.[each discussion] 1. Tang Materia Medica: waist, kidney, foot knee joint, gather, all cold diseases of enteral, be not recovered for many years, the effect of clothes.2. " Kaibao Bencao ": main all wind, Xuan Tongwu hides, and go in abdomen cold stagnant, septum cordis expectorant water amasss for a long time, lump in the abdomen mass beside the umbilicus air parcel, bladder place pus aversion to water, the cold pain of waist knee joint and treatment injured.3. amplification on Canon of Materia Medica: control hemorrhoidal hamorrhage.4. " herbal classic is met former ": varioliform exanthema poison is stopped up and can not be assigned in upper, under waist, shin knee joint rises and fills with slow person, with under draw.5. " Guangxi Chinese herbal medicine ": expelling wind and removing dampness, dredge the meridian passage, diuresis, pain relieving.Dispelling the wind and dampness pathogens osteodynia, jaundice, edema, dysuria, migraine, internal traumatic injury.6. " marine collection proved recipe ": Radix Clematidis, remove many wind, the logical twelve regular channels, dredge the cold pus retained water of a surname's the five internal organs and become sick, slight diarrhea is not thirsty.People takes this, and extremity are spry and light, and brothers are warm, and obtains refrigerant.[extracts] " China's book on Chinese herbal medicine "
Cortex erythrinae: [another name] CORTEX ERYTHRINAE, drum Cortex paulowniae, CORTEX ERYTHRINAE, transfixation, showy reiolaena root-bark.[source] medical material Ji Yuan: be leguminous plant erythrina indica, Erythrinae Arborescentis dried bark or root bark.[nature and flavor] are bitter; Pungent; Flat.[return through] liver; Spleen; Stomach warp.[function cures mainly] expelling wind and removing dampness; Channels sootheing and network vessel quickening; Killing parasites for relieving itching.Main air pain of dampness syndrome; Podomere contracture; Traumatic injury; Scabies; Eczema.[each discussion] 1. " Japan hanako materia medica ": control blood vessels paralysis pain, and decoct and wash conjunctival congestion.2. " detailed outline ": network of passing through, reach disease institute, again people's blood system and remove wind parasite killing.3. " south of the Five Ridges gather medicinal herbs record ": granulation promoting, pain relieving, loose blood, steamed cold noodles skin, applies traumatic injury.4. " Nanning City's medicine will ": detumescence, loose crazy, pain relieving.Treat cough, only puerperal, crazy blood was had a pain.[extracts] " China's book on Chinese herbal medicine "
Phymatopsis griffithiana (Hook.) J. Sm.: [another name] golden bracelet grass, large Venus phoenix tail, Herba Pteridis Multifidae, Folium Pyrrosiae, cow tongue Herba pteridii latiusculi.[source] medical material Ji Yuan: be the herb of Plants of Polypodiaceae Phymatopsis integrifolia Ching.[nature and flavor] are bitter; Cold.[return through] heart; Large intestine; Small intestinal; Spleen channel.[function cures mainly] clearing away heat and cooling blood; Removing toxic substances and promoting subsidence of swelling.Main carbuncle and ulcer; Toxic swelling; Scrofula; Malignant boil; Sudden and violent red acute catarrhal conjunctivitis; Cough due to lung-heat; Stranguria; Discharging fresh blood stool.[each discussion] 1. " good help book on Chinese herbal medicine ": main skin sore, sulfur poison of having a bowel movement, carbuncle on the back, carbuncle, tuberculosis, with the decoction of leaf root wine it; Last cold water clothes can be made again and be coated with carbuncle on the back skin ulcer swollen on.The immersion oil coating head that root is broken, piliation.2. " book on Chinese herbal medicine covers bamboo fish trap ": removing toxic substances and promoting subsidence of swelling, specially manage surgery.From the beginning of malignant boil, YANG toxin syndrome of not bursting, controls neck scrofula, carbuncle on the back carbuncle.3. Compendium of Material Medica: antipyretic, logical five types of stranguria, removing heat from blood.[extracts] " China's book on Chinese herbal medicine "
Fructus Arctii: [another name] Fructus Arctii, evil are real.[source] this product is the dry mature fruit of feverfew Fructus Arctii.[nature and flavor] are pungent, bitter, cold.[return through] attaches to the lung and stomach meridians.[function cures mainly] dispelling wind and heat pathogens, lung qi dispersing rash, resolving toxin and disinhibiting the throat.For anemopyretic cold, cough with copious phlegm, measles, rubella, laryngopharynx swelling and pain, mumps erysipelas, carbuncle sore tumefacting virus.[extracts] " Chinese Pharmacopoeia "
The ratio of weight and number of the various raw medicinal materials in described Chinese medicine preparation can be preferably: Herba Sonchi Arvensis 10 ~ 25 parts, Herba Duchesneae Indicae 15 ~ 25 parts, Radix Polygoni Multiflori 10 ~ 30 parts, Herba Ixeritis polycephalae 10 ~ 25 parts, Radix Gentianae Herba Violae 15 ~ 30 parts, Dioscorea zingiberensis C. H. Wright 10 ~ 25 parts, Herba Patriniae Rupestris 10 ~ 30 parts, Herba Achilleae 20 ~ 30 parts, Folium Loropetali 15 ~ 25 parts, longpetal globeflower flower 10 ~ 20 parts, stone maple medicine 20 ~ 35 parts, Herba Bidentis Bipinnate (Herba Bidentis Pilosae, Herba Bidentis Pilosae) 15 ~ 30 parts, Herba Briggsiae Chienii 10 ~ 30 parts, Rhizoma Homalomenae 10 ~ 25 parts, Rhizoma Arisaematis 10 ~ 25 parts, Radix Clematidis 10 ~ 20 parts, Cortex erythrinae 10 ~ 30 parts, Phymatopsis griffithiana (Hook.) J. Sm. 15 ~ 25 parts and Fructus Arctii 10 ~ 25 parts.
The ratio of weight and number of the various raw medicinal materials in described Chinese medicine preparation can also more preferably: Herba Sonchi Arvensis 10 ~ 15 parts, Herba Duchesneae Indicae 20 ~ 25 parts, Radix Polygoni Multiflori 15 ~ 25 parts, Herba Ixeritis polycephalae 15 ~ 25 parts, Radix Gentianae Herba Violae 20 ~ 25 parts, Dioscorea zingiberensis C. H. Wright 15 ~ 20 parts, Herba Patriniae Rupestris 20 ~ 30 parts, Herba Achilleae 25 ~ 30 parts, Folium Loropetali 15 ~ 20 parts, longpetal globeflower flower 10 ~ 15 parts, stone maple medicine 25 ~ 35 parts, Herba Bidentis Bipinnate (Herba Bidentis Pilosae, Herba Bidentis Pilosae) 20 ~ 30 parts, Herba Briggsiae Chienii 15 ~ 25 parts, Rhizoma Homalomenae 10 ~ 15 parts, Rhizoma Arisaematis 15 ~ 20 parts, Radix Clematidis 15 ~ 20 parts, Cortex erythrinae 20 ~ 30 parts, Phymatopsis griffithiana (Hook.) J. Sm. 20 ~ 25 parts and Fructus Arctii 15 ~ 25 parts.
The ratio of weight and number of the various raw medicinal materials in described Chinese medicine preparation also can more preferably: Herba Sonchi Arvensis 13 parts, Herba Duchesneae Indicae 23 parts, Radix Polygoni Multiflori 20 parts, Herba Ixeritis polycephalae 21 parts, Radix Gentianae Herba Violae 22 parts, Dioscorea zingiberensis C. H. Wright 18 parts, Herba Patriniae Rupestris 25 parts, Herba Achilleae 26 parts, Folium Loropetali 18 parts, longpetal globeflower flower 15 parts, stone maple medicine 27 parts, Herba Bidentis Bipinnate (Herba Bidentis Pilosae, Herba Bidentis Pilosae) 25 parts, Herba Briggsiae Chienii 23 parts, Rhizoma Homalomenae 13 parts, Rhizoma Arisaematis 18 parts, Radix Clematidis 16 parts, Cortex erythrinae 25 parts, Phymatopsis griffithiana (Hook.) J. Sm. 22 parts and Fructus Arctii 20 parts.
When the dosage form of described Chinese medicine preparation is granule, it comprises the following steps:
Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 5 ~ 6 times, mixture is the ethanol of 80% ~ 95%, be heated to boiling reflux 4 ~ 6 hours, filter, take backflow as solvent, take filtering residue as solute, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.08Mpa, relative density is the mastic of 1.05 ~ 1.10, spraying dry, the inlet temperature of spray dryer 160 ~ 175 DEG C, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder,
Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 ~ 0.4 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes granule, in 40 ~ 50 DEG C of dryings, obtains granule.
When the dosage form of described Chinese medicine preparation is capsule, it comprises the following steps:
The first step, Herba Sonchi Arvensis, Herba Duchesneae Indicae, Radix Polygoni Multiflori, Herba Ixeritis polycephalae, Radix Gentianae Herba Violae and Dioscorea zingiberensis C. H. Wright are mixed in described ratio, add the water extraction volatile oil relative to 4 ~ 6 times, mixture, by the volatile oil beta-cyclodextrin inclusion compound obtained, the ratio of volatile oil and beta-schardinger dextrin-is 1: 3 ~ 6, stirs 75 minutes ~ 90 minutes, temperature 30 DEG C ~ 50 DEG C, obtain volatile oil clathrate compound, for subsequent use; Another when aqueous extract being concentrated into 60 DEG C relative density be the clear paste of 1.15 ~ 1.17;
Second step, Folium Loropetali, longpetal globeflower flower, stone maple medicine, Herba Briggsiae Chienii, Rhizoma Homalomenae, Rhizoma Arisaematis and Cortex erythrinae are mixed in described ratio, add relative to mixture 6 ~ 8 times amount determining alcohol be 80% ~ 90% alcohol reflux 3 ~ 5 times, each 2 ~ 3 hours, filter, filtrate merges, and reclaims ethanol, when being concentrated into 60 DEG C, relative density is the clear paste of 1.20 ~ 1.22, for subsequent use;
3rd step, will remain described raw medicinal material and mix in described ratio, add relative to mixture 8 ~ 10 times of water gagings, boil 6 ~ 8 hours, filter, and when being concentrated into 65 DEG C, relative density is the clear paste of 1.28 ~ 1.30;
4th step, mixed by the clear paste of the first step, second step, the 3rd step, 60 DEG C ~ 70 DEG C reduced vacuum dryings, get dry extract powder;
5th step, dried cream powder described in volatile oil clathrate compound described in the first step and the 4th step is fully mixed, add the mixture relative to volatile oil clathrate compound described in 100 weight portions and dried cream powder subsequently, 5 ~ 8 weight portion carboxymethyl starch sodium, 10 ~ 50 weight starch mix homogeneously, adding 150 ~ 200 weight portion determining alcohols is 80% ~ 90% alcohol granulation, dry, granulate, add the mixture relative to volatile oil clathrate compound described in 100 weight portions and dried cream powder subsequently, 3 ~ 5 weight portion magnesium stearate, then load in gelatine capsule.
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.
Embodiment 1: granule prepared by the present invention
Get Herba Sonchi Arvensis 130g, Herba Duchesneae Indicae 230g, Radix Polygoni Multiflori 200g, Herba Ixeritis polycephalae 210g, Radix Gentianae Herba Violae 220g, Dioscorea zingiberensis C. H. Wright 180g, Herba Patriniae Rupestris 250g, Herba Achilleae 260g, Folium Loropetali 180g, longpetal globeflower flower 150g, stone maple medicine 270g, Herba Bidentis Bipinnate (Herba Bidentis Pilosae, Herba Bidentis Pilosae) 250g, Herba Briggsiae Chienii 230g, Rhizoma Homalomenae 130g, Rhizoma Arisaematis 180g, Radix Clematidis 160g, Cortex erythrinae 250g, Phymatopsis griffithiana (Hook.) J. Sm. 220g and Fructus Arctii 200g.
Its preparation method comprises the following steps:
Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 5 times, mixture is the ethanol of 85%, be heated to boiling reflux 5 hours, filter, take backflow as solvent, take filtering residue as solute, adopt percolation with the speed of 2ml per minute slowly percolation, collect percolate, when being evaporated to 55 DEG C subsequently under vacuum 0.08Mpa, relative density is the mastic of 1.05, spraying dry, the inlet temperature 165 DEG C of spray dryer, leaving air temp 85 DEG C, be ground into powder subsequently, make dried cream powder;
Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.3 times and 0.2 times in the dried cream powder obtained, makes granule, in 45 DEG C of dryings, obtains granule.
Embodiment 2: capsule prepared by the present invention
Get Herba Sonchi Arvensis 110g, Herba Duchesneae Indicae 220g, Radix Polygoni Multiflori 240g, Herba Ixeritis polycephalae 170g, Radix Gentianae Herba Violae 250g, Dioscorea zingiberensis C. H. Wright 160g, Herba Patriniae Rupestris 280g, Herba Achilleae 290g, Folium Loropetali 160g, longpetal globeflower flower 120g, stone maple medicine 330g, Herba Bidentis Bipinnate (Herba Bidentis Pilosae, Herba Bidentis Pilosae) 280g, Herba Briggsiae Chienii 160g, Rhizoma Homalomenae 110g, Rhizoma Arisaematis 170g, Radix Clematidis 180g, Cortex erythrinae 280g, Phymatopsis griffithiana (Hook.) J. Sm. 240g and Fructus Arctii 230g.
Its preparation method comprises the following steps:
The first step, Herba Sonchi Arvensis, Herba Duchesneae Indicae, Radix Polygoni Multiflori, Herba Ixeritis polycephalae, Radix Gentianae Herba Violae and Dioscorea zingiberensis C. H. Wright are mixed in described ratio, add the water extraction volatile oil relative to 5 times, mixture, by the volatile oil beta-cyclodextrin inclusion compound obtained, the ratio of volatile oil and beta-schardinger dextrin-is 1: 4, stirs 80 minutes, temperature 40 DEG C, obtain volatile oil clathrate compound, for subsequent use; Another when aqueous extract being concentrated into 60 DEG C relative density be the clear paste of 1.16;
Second step, Folium Loropetali, longpetal globeflower flower, stone maple medicine, Herba Briggsiae Chienii, Rhizoma Homalomenae, Rhizoma Arisaematis and Cortex erythrinae are mixed in described ratio, add relative to mixture 6 times amount determining alcohol be 85% alcohol reflux 4 times, each 3 hours, filter, filtrate merges, and reclaims ethanol, when being concentrated into 60 DEG C, relative density is the clear paste of 1.20, for subsequent use;
3rd step, will remain described raw medicinal material and mix in described ratio, add relative to mixture 9 times of water gagings, boil 8 hours, filter, and when being concentrated into 65 DEG C, relative density is the clear paste of 1.28;
4th step, mixed by the clear paste of the first step, second step, the 3rd step, 65 DEG C of reduced vacuum dryings, get dry extract powder;
5th step, dried cream powder described in volatile oil clathrate compound described in the first step and the 4th step is fully mixed, subsequently relative to the mixture of volatile oil clathrate compound described in 100 weight portions and dried cream powder, add 6 weight portion carboxymethyl starch sodium, 30 weight starch mix homogeneously, adding 160 weight portion determining alcohols is 85% alcohol granulation, dry, granulate, subsequently relative to the mixture of volatile oil clathrate compound described in 100 weight portions and dried cream powder, add 4 weight portion magnesium stearate, then load in gelatine capsule.
Toxicity test:
Acute toxicity testing: application mice 60, male and female half and half, body weight 22-32g, carries out acute toxicity test.Mice is divided into two groups at random, i.e. matched group and administration group, before experiment, fasting 12 hours, is dissolved in water by Chinese medicine granules prepared by embodiments of the invention 1, (concentration is 8.54g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg (namely unit dosage form is 42.7 crude drugs/kg), and matched group gives normal saline, administration in one day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage granule LD50>42.7 crude drug/kg of the present invention, every day, maximum dosage-feeding was 85.4 crude drugs/kg/ day.Chinese medicine clinical application amount of the present invention be 8.65g crude drug/day/people, adult body weight in 60KG, average dosage is 0.144g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 27g) oral administration gavage Chinese medicine of the present invention is 593 times of quantity.Therefore Chinese medicine acute toxicity of the present invention is extremely low, clinical drug safety.
Long term toxicity test: Chinese medicine embodiment 1 granule of the present invention to three groups of mices (often organize 20) by 13.24,25.46 and 42.37g crude drug/kg continuous use 15 weeks (1.0ml/100g body weight, every day 2 times) and drug withdrawal after 3 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 15 weeks and drug withdrawal are after 3 weeks, and Organs of Mice is all without obviously changing.Illustrate that Chinese medicine of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.
Clinical data:
Case selection: all 140 routine cases all derive from this Out-patient Department and inpatient, man 73 example, female 67 example.Age 20-40 year 74 examples, 41-60 year 53 examples, more than 61 years old 13 is routine; The course of disease is 20 examples below 1 year, 1-2 49 example, 2-3 43 example, more than 3 years 28 examples.Be divided into treatment group and matched group at random, wherein, treatment group 70 people, man 37 example, female 33 example.Age 20-40 year 37 examples, 41-60 year 27 examples, more than 61 years old 6 is routine; The course of disease is 10 examples below 1 year, 1-2 25 example, 2-3 21 example, more than 3 years 14 examples.Treatment group 70 people, man 36 example, female 34 example.Age 20-40 year 37 examples, 41-60 year 26 examples, more than 61 years old 7 is routine; The course of disease is 10 examples below 1 year, 1-2 24 example, 2-3 22 example, more than 3 years 14 examples.Treatment group and matched group be no significant difference (P≤0.01) on age and clinical symptoms, has comparability.
Clinical manifestation is: (1) majority has typical acute appendicitis history of attack; (2) Right Lower Abdomen pain recurrent exerbation, Right Lower Abdomen limitation fixes tenderness; (3) B ultrasonic display vermiform appendix enlargement, routine blood test shows: leukocyte increases in various degree; (4) loss of appetite, lassitude, weak.
Diagnostic criteria: 1, chronic abdominal pain, is only confined to Right Lower Abdomen.2, acute appendicitis history is had, the recurrent exerbation of interval a few days or longer time.3, sign: wheat formula point tenderness is obvious, or Right Lower Abdomen touches appendix mass.4, auxiliary examination: x-ray barium meal examination show vermiform appendix chamber underfilling or the agent of vermiform appendix intracavity barium emptying slow, there is tenderness local, or shows stationary state.Routine blood test shows: leukocyte increases in various degree.5, the diseases such as peritonitis-perforation, gastroenteritis, Gastroduodenal perforation, right ureter calculus, acute mesenteric lymphadenitis are got rid of.
Therapeutic Method:
Matched group: take antiinflammatory, support, anti symptom treatment mode treat.By ceftriaxone sodium 2g, adding gentamycin 240,000 unit and first nitre file 1g proportioning, give patient intravenous drip, the patient without obviously heating is infused 1000-1500ml every day, to infuse every day 2000ml to there being the patient of obviously heating.Give oral vitamin C anti inflammatory detoxication simultaneously, improve patient's body tolerance; Continuous treatment 10 days.
Treatment group: on the basis for the treatment of of control group, treatment group patient is oral Chinese medicine embodiment 1 granule of the present invention simultaneously, each 30g, every day 3 times; Continuous treatment 10 days.
Curative effect judging standard: (1) cures: Right Lower Abdomen pain disappears, tenderness and rebound tenderness feminine gender, appetite increases, and spirit is normal, and weak without feel, the auxiliary examinations such as routine blood test all recover normal; (2) take a turn for the better: Right Lower Abdomen pain obviously alleviates; When time is done only, without tenderness and rebound tenderness, diet improves, and spirit takes a turn for the better, and the auxiliary examinations such as routine blood test are improved; (3) invalid: the symptoms such as Right Lower Abdomen pain are without improvement or increase the weight of.
Therapeutic outcome: two groups treat 10 days respectively after, statistical result is see table 1 and table 2.
Table 1 liang group treats Clinical efficacy comparison after 10 days (unit: example) respectively
| Group | Number of cases | Cure | Take a turn for the better | Invalid | Total effective rate |
| Treatment group | 70 | 45 | 22 | 3 | 67(95.71％) |
| Matched group | 70 | 28 | 29 | 13 | 57(81.43％) |
As can be seen from Table 1, treatment group adopts Chinese medicine of the present invention, coordinates western medical treatment chronic appendicitis, relative to matched group, on therapeutic effect, has significant improvement.
Table 2 liang group treats 10 days healing numbers afterwards respectively and the time compares (unit: example/%)
| Group | Number of cases | Medication 5 days | Medication 7 days | Medication 10 days |
| Treatment group | 45 | 22(31.43％) | 36(51.43％) | 45(64.29％) |
| Matched group | 28 | 9(12.86％) | 19(27.41％) | 28(40％) |
As can be seen from Table 2, treatment group adopts Chinese medicine of the present invention, and coordinate western medical treatment chronic appendicitis, relative to matched group, not only better efficacy, takes effect also faster.
According to the clinical statistics in toxicity test and above table, Chinese medicine provided by the invention has high, the rapid-action advantage of safe without toxic side effect, effective percentage; Follow up a case by regular visits to 6 months respectively to 28 of 45 and the matched group healing that treatment group is cured, result is added up, and treatment group is without recurrence, and relapse rate is 0% simultaneously; Matched group, recurs 4 people, relapse rate 14.29%.
Concrete case: Xu certain, man, 45 years old, chronic appendicitis recurrent exerbation about 3 years was suffered from private prosecution, and each outbreak is alleviated after all adopting antibiotic, analgesic to treat.Recently bring out because of improper diet, be reluctant operative treatment.Chronic appendicitis is diagnosed as through clinical symptoms and auxiliary examination.Take antiinflammatory, support, anti symptom treatment mode treat, the granule of oral inventive embodiments 1 simultaneously, each 30g, every day 3 times, takes appetite after the 2nd day and improves, spirit takes a turn for the better, after 5 days, appetite is normal, and without tenderness and rebound tenderness, diet improves, spirit takes a turn for the better, and the check of B ultrasonic, routine blood test has clear improvement; Treat after 7 days, Right Lower Abdomen pain disappears, tenderness and rebound tenderness feminine gender, and appetite increases, and spirit is normal, weak without feel, and the auxiliary examinations such as routine blood test are normal, cures, and follows up a case by regular visits to 6 months without recurrence.
All above-mentioned this intellectual properties of primary enforcement, not setting restriction this new product of other forms of enforcement or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.
The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.
Claims (8)
1. treat the Chinese medicine preparation of chronic appendicitis for one kind, it is characterized in that, described Chinese medicine preparation comprises following raw medicinal material: Herba Sonchi Arvensis, Herba Duchesneae Indicae, Radix Polygoni Multiflori, Herba Ixeritis polycephalae, Radix Gentianae Herba Violae, Dioscorea zingiberensis C. H. Wright, Herba Patriniae Rupestris, Herba Achilleae, Folium Loropetali, longpetal globeflower flower, stone maple medicine, Herba Bidentis Bipinnate (Herba Bidentis Pilosae, Herba Bidentis Pilosae), Herba Briggsiae Chienii, Rhizoma Homalomenae, Rhizoma Arisaematis, Radix Clematidis, Cortex erythrinae, Phymatopsis griffithiana (Hook.) J. Sm. and Fructus Arctii.
2. Chinese medicine preparation as claimed in claim 1, it is characterized in that, the ratio of weight and number of described raw medicinal material is: Herba Sonchi Arvensis 10 ~ 25 parts, Herba Duchesneae Indicae 15 ~ 25 parts, Radix Polygoni Multiflori 10 ~ 30 parts, Herba Ixeritis polycephalae 10 ~ 25 parts, Radix Gentianae Herba Violae 15 ~ 30 parts, Dioscorea zingiberensis C. H. Wright 10 ~ 25 parts, Herba Patriniae Rupestris 10 ~ 30 parts, Herba Achilleae 20 ~ 30 parts, Folium Loropetali 15 ~ 25 parts, longpetal globeflower flower 10 ~ 20 parts, stone maple medicine 20 ~ 35 parts, Herba Bidentis Bipinnate (Herba Bidentis Pilosae, Herba Bidentis Pilosae) 15 ~ 30 parts, Herba Briggsiae Chienii 10 ~ 30 parts, Rhizoma Homalomenae 10 ~ 25 parts, Rhizoma Arisaematis 10 ~ 25 parts, Radix Clematidis 10 ~ 20 parts, Cortex erythrinae 10 ~ 30 parts, Phymatopsis griffithiana (Hook.) J. Sm. 15 ~ 25 parts and Fructus Arctii 10 ~ 25 parts.
3. Chinese medicine preparation as claimed in claim 1 or 2, it is characterized in that, the ratio of weight and number of described raw medicinal material is: Herba Sonchi Arvensis 10 ~ 15 parts, Herba Duchesneae Indicae 20 ~ 25 parts, Radix Polygoni Multiflori 15 ~ 25 parts, Herba Ixeritis polycephalae 15 ~ 25 parts, Radix Gentianae Herba Violae 20 ~ 25 parts, Dioscorea zingiberensis C. H. Wright 15 ~ 20 parts, Herba Patriniae Rupestris 20 ~ 30 parts, Herba Achilleae 25 ~ 30 parts, Folium Loropetali 15 ~ 20 parts, longpetal globeflower flower 10 ~ 15 parts, stone maple medicine 25 ~ 35 parts, Herba Bidentis Bipinnate (Herba Bidentis Pilosae, Herba Bidentis Pilosae) 20 ~ 30 parts, Herba Briggsiae Chienii 15 ~ 25 parts, Rhizoma Homalomenae 10 ~ 15 parts, Rhizoma Arisaematis 15 ~ 20 parts, Radix Clematidis 15 ~ 20 parts, Cortex erythrinae 20 ~ 30 parts, Phymatopsis griffithiana (Hook.) J. Sm. 20 ~ 25 parts and Fructus Arctii 15 ~ 25 parts.
4. the Chinese medicine preparation as described in claims 1 to 3, it is characterized in that, the ratio of weight and number of described raw medicinal material is: Herba Sonchi Arvensis 13 parts, Herba Duchesneae Indicae 23 parts, Radix Polygoni Multiflori 20 parts, Herba Ixeritis polycephalae 21 parts, Radix Gentianae Herba Violae 22 parts, Dioscorea zingiberensis C. H. Wright 18 parts, Herba Patriniae Rupestris 25 parts, Herba Achilleae 26 parts, Folium Loropetali 18 parts, longpetal globeflower flower 15 parts, stone maple medicine 27 parts, Herba Bidentis Bipinnate (Herba Bidentis Pilosae, Herba Bidentis Pilosae) 25 parts, Herba Briggsiae Chienii 23 parts, Rhizoma Homalomenae 13 parts, Rhizoma Arisaematis 18 parts, Radix Clematidis 16 parts, Cortex erythrinae 25 parts, Phymatopsis griffithiana (Hook.) J. Sm. 22 parts and Fructus Arctii 20 parts.
5. the Chinese medicine preparation as described in Claims 1-4, is characterized in that, the dosage form of described Chinese medicine preparation is granule, and its preparation method comprises the following steps:
Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 5 ~ 6 times, mixture is the ethanol of 80% ~ 95%, be heated to boiling reflux 4 ~ 6 hours, filter, take backflow as solvent, take filtering residue as solute, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.08Mpa, relative density is the mastic of 1.05 ~ 1.10, spraying dry, the inlet temperature of spray dryer 160 ~ 175 DEG C, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder,
Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 ~ 0.4 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes granule, in 40 ~ 50 DEG C of dryings, obtains granule.
6. the Chinese medicine preparation as described in Claims 1-4, is characterized in that, the dosage form of described Chinese medicine preparation is capsule, and its preparation method comprises the following steps:
The first step, Herba Sonchi Arvensis, Herba Duchesneae Indicae, Radix Polygoni Multiflori, Herba Ixeritis polycephalae, Radix Gentianae Herba Violae and Dioscorea zingiberensis C. H. Wright are mixed in described ratio, add the water extraction volatile oil relative to 4 ~ 6 times, mixture, by the volatile oil beta-cyclodextrin inclusion compound obtained, the ratio of volatile oil and beta-schardinger dextrin-is 1: 3 ~ 6, stirs 75 minutes ~ 90 minutes, temperature 30 DEG C ~ 50 DEG C, obtain volatile oil clathrate compound, for subsequent use; Another when aqueous extract being concentrated into 60 DEG C relative density be the clear paste of 1.15 ~ 1.17;
Second step, Folium Loropetali, longpetal globeflower flower, stone maple medicine, Herba Briggsiae Chienii, Rhizoma Homalomenae, Rhizoma Arisaematis and Cortex erythrinae are mixed in described ratio, add relative to mixture 6 ~ 8 times amount determining alcohol be 80% ~ 90% alcohol reflux 3 ~ 5 times, each 2 ~ 3 hours, filter, filtrate merges, and reclaims ethanol, when being concentrated into 60 DEG C, relative density is the clear paste of 1.20 ~ 1.22, for subsequent use;
3rd step, will remain described raw medicinal material and mix in described ratio, add relative to mixture 8 ~ 10 times of water gagings, boil 6 ~ 8 hours, filter, and when being concentrated into 65 DEG C, relative density is the clear paste of 1.28 ~ 1.30;
4th step, mixed by the clear paste of the first step, second step, the 3rd step, 60 DEG C ~ 70 DEG C reduced vacuum dryings, get dry extract powder;
5th step, dried cream powder described in volatile oil clathrate compound described in the first step and the 4th step is fully mixed, add the mixture relative to volatile oil clathrate compound described in 100 weight portions and dried cream powder subsequently, 5 ~ 8 weight portion carboxymethyl starch sodium, 10 ~ 50 weight starch mix homogeneously, adding 150 ~ 200 weight portion determining alcohols is 80% ~ 90% alcohol granulation, dry, granulate, add the mixture relative to volatile oil clathrate compound described in 100 weight portions and dried cream powder subsequently, 3 ~ 5 weight portion magnesium stearate, then load in gelatine capsule.
7. a preparation method for the Chinese medicine preparation described in Claims 1-4, is characterized in that, the dosage form of described Chinese medicine preparation is granule, and it comprises the following steps:
Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 5 ~ 6 times, mixture is the ethanol of 80% ~ 95%, be heated to boiling reflux 4 ~ 6 hours, filter, take backflow as solvent, take filtering residue as solute, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.08Mpa, relative density is the mastic of 1.05 ~ 1.10, spraying dry, the inlet temperature of spray dryer 160 ~ 175 DEG C, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder,
Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 ~ 0.4 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes granule, in 40 ~ 50 DEG C of dryings, obtains granule.
8. a preparation method for the Chinese medicine preparation described in Claims 1-4, is characterized in that, the dosage form of described Chinese medicine preparation is capsule, and its preparation method comprises the following steps:
The first step, Herba Sonchi Arvensis, Herba Duchesneae Indicae, Radix Polygoni Multiflori, Herba Ixeritis polycephalae, Radix Gentianae Herba Violae and Dioscorea zingiberensis C. H. Wright are mixed in described ratio, add the water extraction volatile oil relative to 4 ~ 6 times, mixture, by the volatile oil beta-cyclodextrin inclusion compound obtained, the ratio of volatile oil and beta-schardinger dextrin-is 1: 3 ~ 6, stirs 75 minutes ~ 90 minutes, temperature 30 DEG C ~ 50 DEG C, obtain volatile oil clathrate compound, for subsequent use; Another when aqueous extract being concentrated into 60 DEG C relative density be the clear paste of 1.15 ~ 1.17;
Second step, Folium Loropetali, longpetal globeflower flower, stone maple medicine, Herba Briggsiae Chienii, Rhizoma Homalomenae, Rhizoma Arisaematis and Cortex erythrinae are mixed in described ratio, add relative to mixture 6 ~ 8 times amount determining alcohol be 80% ~ 90% alcohol reflux 3 ~ 5 times, each 2 ~ 3 hours, filter, filtrate merges, and reclaims ethanol, when being concentrated into 60 DEG C, relative density is the clear paste of 1.20 ~ 1.22, for subsequent use;
3rd step, will remain described raw medicinal material and mix in described ratio, add relative to mixture 8 ~ 10 times of water gagings, boil 6 ~ 8 hours, filter, and when being concentrated into 65 DEG C, relative density is the clear paste of 1.28 ~ 1.30;
4th step, mixed by the clear paste of the first step, second step, the 3rd step, 60 DEG C ~ 70 DEG C reduced vacuum dryings, get dry extract powder;
5th step, dried cream powder described in volatile oil clathrate compound described in the first step and the 4th step is fully mixed, add the mixture relative to volatile oil clathrate compound described in 100 weight portions and dried cream powder subsequently, 5 ~ 8 weight portion carboxymethyl starch sodium, 10 ~ 50 weight starch mix homogeneously, adding 150 ~ 200 weight portion determining alcohols is 80% ~ 90% alcohol granulation, dry, granulate, add the mixture relative to volatile oil clathrate compound described in 100 weight portions and dried cream powder subsequently, 3 ~ 5 weight portion magnesium stearate, then load in gelatine capsule.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101199627A (en) * | 2007-12-12 | 2008-06-18 | 陈德顺 | Chinese medicine agent for treating chronicity appendicitis |
| CN101658652A (en) * | 2008-08-29 | 2010-03-03 | 王广仁 | Chinese medicinal preparation for treating chronic appendicitis |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101199627A (en) * | 2007-12-12 | 2008-06-18 | 陈德顺 | Chinese medicine agent for treating chronicity appendicitis |
| CN101658652A (en) * | 2008-08-29 | 2010-03-03 | 王广仁 | Chinese medicinal preparation for treating chronic appendicitis |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105920421A (en) * | 2016-06-23 | 2016-09-07 | 吴兴龙 | Traditional Chinese medicinal preparation for treating chronic appendicitis and preparation method thereof |
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