CN105362602A - Traditional Chinese medicine preparation for treating dysfunctional uterine bleeding and preparation method of traditional Chinese medicine preparation for treating dysfunctional uterine bleeding - Google Patents
Traditional Chinese medicine preparation for treating dysfunctional uterine bleeding and preparation method of traditional Chinese medicine preparation for treating dysfunctional uterine bleeding Download PDFInfo
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- CN105362602A CN105362602A CN201510888867.XA CN201510888867A CN105362602A CN 105362602 A CN105362602 A CN 105362602A CN 201510888867 A CN201510888867 A CN 201510888867A CN 105362602 A CN105362602 A CN 105362602A
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Abstract
The invention provides a traditional Chinese medicine preparation for treating dysfunctional uterine bleeding and a preparation method of the traditional Chinese medicine preparation for treating dysfunctional uterine bleeding. The traditional Chinese medicine preparation comprises caulis sargentodoxae, limonitum, ageratum conyzoides L., semen juglandis, viviparous bistort rhizome, iris tenuifolia Pall., asclepias curassavica L., rhizome of dryopteris filix-mas (L.) Schott [Polypodium filix-mas L.], root of evans begonia, rohdea japonica (Thunb.) Roth., cuspidat Mnium, pinellia integrifolia N. E. Brown, elaeagnus pungens Thunb., radix toddaliae asiaticae, razor clam shell, root of schoch craspedolobium, celosia cristata L. [C.Argentea L.var.Cristata (L.) O.Kuntze] and salvia cavaleriei Levl.var. simplicifolia Stib.. The traditional Chinese medicine preparation and the preparation method thereof have the advantages that the traditional Chinese medicine preparation is convenient to use, free from toxic or side effect and high in efficiency, cure rate can be increased remarkably, and preparation technologies are simple.
Description
Technical field
The present invention relates to engineering of traditional Chinese medicine technical field, particularly relate to a kind of Chinese medicine for the treatment of dysfunctional uterine bleeding and preparation method thereof.
Background technology
Dysfunctional uterine bleeding (dysfunctionuterinebleeding, DUB) is called for short anovulatory dysfunctional uterine hemorrhage.Being owing to regulating nerve, the not normal metrorrhagia of endocrine mechanism of reproduction, is non-organic disease, is multiplely born in adolescence and involutional women, to occur in any age of menarche to menopause.Clinical manifestation is the confusion of the menstrual cycle, menorrhagia, menostaxis, even irregular colporrhagia.Usually ovulation type and anovulation type two class is divided into.
Dysfunctional uterine bleeding is one of common menopathy of women, and caused by her ovaries's functional disorder, reproductive system is without significant organic pathological changes.In the traditional Chinese medical science, belong to " metrorrhagia " category, record in " General Treatise on the Cause and Symptoms of Diseases ": " lower dripping urine endlessly time non-, leaking down of meaning.", " under suddenly sudden and violent, the metrorrhagia of meaning.", though the two has the order of importance and emergency different, normal conversion mutually in advancing of disease process, therefore generally claim metrorrhagia.The pathogenesis of metrorrhagia is intricate, and the course of disease is touching, and repeatedly difficult, the traditional Chinese medical science thinks that the generation of primary disease can by deficient QI failing to control, spleen injury, liver-yang hyperactivity heat in blood, and suffering from a deficiency of the kidney, it is solid to lose, and impairment caused by overstrain punching is appointed, and qi depression to blood stasis, eating and drinking without temperance etc. cause.The primary disease pathogeny mainly impairment of chong and ren channels, can not astringency inducing.
Summary of the invention
Technical problem to be solved by this invention is, utilizes the theory of Chinese medical science that China is traditional, provides a kind of therapeutic effect good and Chinese medicine of the treatment dysfunctional uterine bleeding that toxic and side effects is little and preparation method thereof.
In order to solve the problems of the technologies described above, the invention provides a kind of Chinese medicine for the treatment of dysfunctional uterine bleeding, described Chinese medicine comprises following raw medicinal material: Caulis Sargentodoxae, Limonitum, Herba Agerati Conyzoidis, Partition in Fructus Juglandis, Rhizoma polygoni vivipari, old cattle are carried, Herba asclepiadis curassaevicae, european aspidium, Radix Bischofiae Javanicae, Rohdea japonica Roth, Mnium cuspidatum Hedw., Bai Lingzi, Fructus Elaeagni, Radix Toddaliae Asiaticae, Concha Solen gouldii, Radix craspedolobii schochii, Caulis et Folium Celosiae cristatae and blood dish grass.
The ratio of weight and number of the various raw medicinal materials in described Chinese medicine can be preferably: Caulis Sargentodoxae 15 ~ 25 parts, Limonitum 15 ~ 30 parts, Herba Agerati Conyzoidis 15 ~ 30 parts, Partition in Fructus Juglandis 10 ~ 25 parts, Rhizoma polygoni vivipari 15 ~ 30 parts, old cattle carries 20 ~ 30 parts, Herba asclepiadis curassaevicae 15 ~ 30 parts, european aspidium 15 ~ 25 parts, Radix Bischofiae Javanicae 10 ~ 25 parts, Rohdea japonica Roth 15 ~ 30 parts, Mnium cuspidatum Hedw. 10 ~ 30 parts, Bai Lingzi 10 ~ 25 parts, Fructus Elaeagni 15 ~ 25 parts, Radix Toddaliae Asiaticae 10 ~ 20 parts, 10 ~ 30 parts, Concha Solen gouldii, 10 ~ 25 parts, Radix craspedolobii schochii, Caulis et Folium Celosiae cristatae 10 ~ 20 parts and blood dish grass 15 ~ 25 parts.
The ratio of weight and number of the various raw medicinal materials in described Chinese medicine can also more preferably: Caulis Sargentodoxae 20 ~ 25 parts, Limonitum 15 ~ 25 parts, Herba Agerati Conyzoidis 15 ~ 25 parts, Partition in Fructus Juglandis 15 ~ 25 parts, Rhizoma polygoni vivipari 20 ~ 25 parts, old cattle carries 25 ~ 30 parts, Herba asclepiadis curassaevicae 20 ~ 30 parts, european aspidium 15 ~ 20 parts, Radix Bischofiae Javanicae 15 ~ 25 parts, Rohdea japonica Roth 20 ~ 30 parts, Mnium cuspidatum Hedw. 15 ~ 25 parts, Bai Lingzi 10 ~ 15 parts, Fructus Elaeagni 15 ~ 20 parts, Radix Toddaliae Asiaticae 15 ~ 20 parts, 20 ~ 30 parts, Concha Solen gouldii, 15 ~ 25 parts, Radix craspedolobii schochii, Caulis et Folium Celosiae cristatae 15 ~ 20 parts and blood dish grass 20 ~ 25 parts.
The ratio of weight and number of the various raw medicinal materials in described Chinese medicine also can more preferably: Caulis Sargentodoxae 23 parts, Limonitum 18 parts, Herba Agerati Conyzoidis 20 parts, Partition in Fructus Juglandis 21 parts, Rhizoma polygoni vivipari 20 parts, old cattle carry 25 parts, Herba asclepiadis curassaevicae 26 parts, european aspidium 18 parts, Radix Bischofiae Javanicae 20 parts, Rohdea japonica Roth 25 parts, Mnium cuspidatum Hedw. 23 parts, Bai Lingzi 13 parts, Fructus Elaeagni 18 parts, Radix Toddaliae Asiaticae 16 parts, 25 parts, Concha Solen gouldii, 20 parts, Radix craspedolobii schochii, Caulis et Folium Celosiae cristatae 15 parts and blood dish grass 22 parts.
When the dosage form of described Chinese medicine is granule, its preparation method comprises the following steps:
Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 5 ~ 6 times, mixture is the ethanol of 80% ~ 95%, be heated to boiling reflux 4 ~ 6 hours, filter, take backflow as solvent, take filtering residue as solute, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.08Mpa, relative density is the mastic of 1.05 ~ 1.10, spraying dry, the inlet temperature of spray dryer 160 ~ 175 DEG C, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder,
Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 ~ 0.4 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes granule, in 40 ~ 50 DEG C of dryings, obtains granule.
When the dosage form of described Chinese medicine is syrup, its preparation method comprises the following steps:
The first step, Caulis Sargentodoxae, Limonitum, Herba Agerati Conyzoidis, Partition in Fructus Juglandis and Rhizoma polygoni vivipari are mixed in described ratio, adding relative to the determining alcohol of 4 ~ 6 times, mixture is the ethanol of 80% ~ 90%, heating and refluxing extraction 2 ~ 4 times, each reflux, extract, 2 hours ~ 3 hours, merge extractive liquid, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 60 DEG C ~ 70 DEG C 60 DEG C, relative density is the medicinal liquid of 1.05 ~ 1.10, by dry with spray dryer for the concentrated solution after concentrated, be ground into 100 ~ 200 orders subsequently, obtain dry powder;
Second step, Herba asclepiadis curassaevicae, european aspidium, Radix Bischofiae Javanicae, Rohdea japonica Roth, Mnium cuspidatum Hedw. and Bai Lingzi are mixed in described ratio, be ground into powder, be that the ethanol of 85% ~ 95% is as solvent with determining alcohol, flood 48 hours ~ 72 hours, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being concentrated into 60 DEG C, relative density is the mastic of 1.25 ~ 1.27, dry with spray dryer, be ground into 100 ~ 200 orders subsequently, obtain dry powder, the quality of the ethanol added is 3 ~ 5 times of second step mixture quality;
3rd step, surplus stock medical material is mixed in described ratio, add relative to mixture 4 ~ 6 times amount determining alcohol be 70% ~ 80% alcohol reflux 2 ~ 4 times, each 1 hour ~ 3 hours, filter, filtrate merges, reclaim ethanol, when being concentrated into 60 DEG C, relative density is the mastic of 1.20 ~ 1.22, in 55 DEG C ~ 65 DEG C reduced vacuum dryings, obtains dry powder;
4th step, by the dry powder blend that the first step obtains to the 3rd step, add the water dissolution relative to mixture quality 3 ~ 5 times, by 40% sodium hydroxide solution adjust ph to 7.0, add correctives sucrose, antiseptic mix homogeneously subsequently, obtain syrup, the correctives added, antiseptic and the content in medicine thereof: sucrose 35 ~ 60%, Pyrusussuriensis acids antiseptic are if potassium sorbate 0.1 ~ 0.3%, paraben preservative are as ethyl hydroxybenzoate 0.01 ~ 0.05%.
Beneficial effect of the present invention: treatment by Chinese herbs dysfunctional uterine bleeding of the present invention, easy to use, have no side effect, effective percentage is high, can also significantly improve cure rate, and preparation technology is simple.
Detailed description of the invention
The invention provides a kind of Chinese medicine for the treatment of dysfunctional uterine bleeding, Chinese medicine comprises following raw medicinal material: Caulis Sargentodoxae, Limonitum, Herba Agerati Conyzoidis, Partition in Fructus Juglandis, Rhizoma polygoni vivipari, old cattle are carried, Herba asclepiadis curassaevicae, european aspidium, Radix Bischofiae Javanicae, Rohdea japonica Roth, Mnium cuspidatum Hedw., Bai Lingzi, Fructus Elaeagni, Radix Toddaliae Asiaticae, Concha Solen gouldii, Radix craspedolobii schochii, Caulis et Folium Celosiae cristatae and blood dish grass.
The pharmacology of various raw medicinal material is as follows:
Caulis Sargentodoxae: [source] this product is the dry rattan of plants of Lardizabalaceae Caulis Sargentodoxae.[nature and flavor] are bitter, flat.[return through] returns large intestine, Liver Channel.[function cures mainly] heat-clearing and toxic substances removing, invigorates blood circulation, dispels the wind.For abdominalgia with intestinal abscess, amenorrhea dysmenorrhea, rheumatic arthralgia, tumbling and swelling.[extracts] " Chinese Pharmacopoeia "
Limonitum: [source] this product is hydroxide class mineral limonites, main containing alkali formula ferrum oxide.[nature and flavor] are sweet, puckery, are slightly cold.[return through] returns stomach, large intestine channel.[function cures mainly] relieving diarrhea with astringents, astringing to arrest bleeding.For chronic diarrhea, chronic dysentery, metrorrhagia, leucorrhea.[extracts] " Chinese Pharmacopoeia "
Herba Agerati Conyzoidis: [source] medical material Ji Yuan: be the herb of feverfew Herba Pogostemonis fish.[nature and flavor] acrid in the mouth; Micro-hardship; Cool in nature.[function cures mainly] heat-clearing and toxic substances removing; Hemostasis; Pain relieving.Main cold, fever; Laryngopharynx swelling and pain; Aphtha of the mouth and tongue; Spitting of blood; Epistaxis; Metrorrhagia; Abdominal pain pain; Traumatic injury; Traumatic hemorrhage; Carbuncle sore tumefacting virus; Eczema pruritus.[extracts] " China's book on Chinese herbal medicine "
Semen Juglandis every.[source] medical material Ji Yuan: be the wooden barrier film in juglandaceae plant Semen Juglandis pit.[nature and flavor] are bitter; Puckery; Property is put down.[return through] spleen; Kidney channel.[function cures mainly] arresting seminal emission reducing urination; Hemostasis leukorrhagia stopping; Antidiarrheal dysentery.Main seminal emission lingering diarrhea; Frequent urination and enuresis; Metrorrhagia; Leukorrhagia, has loose bowels; Dysentery.[extracts] " China's book on Chinese herbal medicine "
Rhizoma polygoni vivipari: [source] medical material Ji Yuan: be the rhizome of polygonaceae plant Polygonum viviparum L., motion eccentric, too white knotweed.[nature and flavor] are bitter; Puckery; Cool in nature.[return through] spleen; Stomach; Large intestine channel.[function cures mainly] heat-clearing and toxic substances removing; Hemostasis; Invigorate blood circulation.Main laryngopharynx swelling and pain; Tonsillitis; Pain pyogenic infections from tumour or sore; Diarrhea due to damp-heat; Dysentery; Leucorrhea with red and white discharge; Spit blood; Epistaxis; Metrorrhagia; Discharging fresh blood stool; Traumatic hemorrhage; Traumatic injury; Lumbago; Arthralgia.[each discussion] 1. " Shaanxi Chinese herbal medicine ": convergence, hemostasis, leukorrhagia stopping.Control dysentery, diarrhoea, wind hematochezia, metrorrhagia, leucorrhea, spit blood, traumatic hemorrhage.2. " plateau Chinese herbal treatment handbook ": control to fall and damage redness, blood stasis pain, rotten deposited affected part.[extracts] " China's book on Chinese herbal medicine "
Old cattle is carried: [another name] antiabortive spirit.[source] medical material Ji Yuan: be rhizome or the root of irides Iris tenuifolia.[nature and flavor] sweet in the mouth; Light; Cool in nature.[function cures mainly] heat-clearing and toxic substances removing; Diuresis is stopped blooding.Main laryngopharynx swelling and pain; Jaundice due to damp-heat; Dysuria; Spit blood; Epistaxis; Metrorrhagia.[extracts] " China's book on Chinese herbal medicine "
Herba asclepiadis curassaevicae: [source] medical material Ji Yuan: be the herb of asclepiadaceae plant milkweed.[nature and flavor] are bitter; Cold in nature.[function cures mainly] heat-clearing and toxic substances removing; Promoting blood circulation and hemostasis; Reducing swelling and alleviating pain.Main laryngopharynx swelling and pain; Cough due to lung-heat; Pyretic stranguria; Menoxenia; Metrorrhagia; Leukorrhagia; Carbuncle pyogenic infections from tumour or sore; Eczema; Stubborn dermatitis; Wound hemorrhage.[each discussion] 1. " Yunnan Chinese herbal medicine ": hemostasis and anti-inflammation, granulation promoting pain relieving.2. " GUIHAIA register ": promoting blood flow to regulate menstruation, anti-inflammatory analgetic, granulation promoting.3. " GUIHAIA register ": control menoxenia, bleeding not during menses, tonsillitis, pneumonia, bronchitis, cystitis, urethritis, flu, knife injury.[extracts] " China's book on Chinese herbal medicine "
European aspidium: [another name] Rhizoma Osmundae, shield-fern.[source] medical material Ji Yuan: be the rhizome of Dryopteridaceae plant Europe shield-fern.[nature and flavor] are bitter; Be slightly cold.[function cures mainly] heat-clearing and toxic substances removing; Cooling blood for hemostasis; Anthelmintic; Inducing diuresis to remove edema.Main cold, fever; Encephalitis b; Mumps; Measles; Metrorrhagia; Intestinal parasitic disease; Edema; Dysuria.[extracts] " China's book on Chinese herbal medicine "
Radix Bischofiae Javanicae: [source] medical material Ji Yuan: be the root of Begoniaceae plant Flos Begoniae Evansianae.[nature and flavor] sour in the mouth; Puckery.[function cures mainly] blood stasis dispelling; Hemostasis; Clearing away heat-damp and promoting diuresis.Main traumatic injury; Spit blood, spit blood; Epistaxis; Knife injury is hemorrhage; Metrorrhagia; Blood stasis amenorrhea; Menoxenia; Leukorrhagia; Stranguria with turbid discharge; Dysentery; Stomachache; Laryngopharynx swelling and pain.[each discussion] 1. " Shaanxi Chinese herbal medicine ": promoting blood circulation to remove blood stasis, heat clearing away, hemostasis and pain-relieving.Control traumatic injury, spit blood, epistaxis, gastric ulcer, dysentery, lung abscess, metrorrhagia, leucorrhea, menoxenia.2. Jiangxi " medical herbs handbook ": circulation of qi promoting promoting the circulation of blood, reducing swelling and alleviating pain, spasmolytic, controls scrofula.[extracts] " China's book on Chinese herbal medicine "
Rohdea japonica Roth: [source] medical material Ji Yuan: be the root and rhizome of liliaceous plant Rohdea japonica Roth.[nature and flavor] are bitter; Micro-sweet; Cold; Slightly poisonous.[return through] lung; Heart channel.[function cures mainly] heat-clearing and toxic substances removing; Heart tonifying diuresis; Cooling blood for hemostasis.Main laryngopharynx swelling and pain; Diphtheria; Sore swollen toxin; Snake bite and insect sting; Heart failure; Edema tympanites; Spitting of blood; Spit blood; Metrorrhagia.[extracts] " China's book on Chinese herbal medicine "
Mnium cuspidatum Hedw.: [another name] Mnium cuspidaum Hedw.[source] medical material Ji Yuan: be the herb of Mniaceae Mnium cuspidaum Hedw.[nature and flavor] are bitter; Light; Cool.[return through] Liver Channel.[function cures mainly] hemostasis removing heat from blood.Main epistaxis; Metrorrhagia; Spit blood; Have blood in stool.[extracts] " China's book on Chinese herbal medicine " " Chinese medicine voluminous dictionary "
Bai Lingzi: [source] medical material Ji Yuan: be the tuber of orchid taro orchid.[nature and flavor] sweet in the mouth; Bitter; Cool in nature.[function cures mainly] clearing away heat-damp and promoting diuresis; Hemostasis.Main stranguria; Nebulousurine; Leucorrhea; Metrorrhagia.[extracts] " China's book on Chinese herbal medicine "
Fructus Elaeagni: [source] medical material Ji Yuan: be the fruit of Elaeangnaceae plant Fructus Elaeagni.[nature and flavor] acid; Puckery; Flat.[return through] lung; Stomach; Large intestine channel.[function cures mainly] astringing to arrest diarrhea; Strengthening the spleen to promote digestion; Relieving cough and asthma; Hemostasis.Master has loose bowels; Dysentery; Inappetence; Dyspepsia; Cough and asthma; Metrorrhagia; Hemorrhoid hematochezia.[each discussion] 1. " Fujian traditional herbal medicine ": hemostasis, treat dysentery.2. Jinhua " conventional Chinese herbal folk proved recipe a collection of selected materials ": astringing to arrest diarrhea, relieving cough and asthma.Control dyspepsia, hernia, breath with cough, metrorrhagia, osteomyelitis, hemorrhoid, lumbar strain.[extracts] " China's book on Chinese herbal medicine "
Radix Toddaliae Asiaticae: [source] medical material Ji Yuan: be root or the root bark of rutaceae Radix Toddaliae Asiaticae.[nature and flavor] are pungent; Micro-hardship; Warm in nature.[function cures mainly] wind-expelling pain-stopping; Dissipating blood stasis stops blooding; Removing toxic substances and promoting subsidence of swelling.Main air pain of dampness syndrome; Lumbago; Stomachache; Dysmenorrhea; Amenorrhea; Traumatic injury; Over-strained hemoptysis; Epistaxis; The stagnant metrorrhagia of the stasis of blood; Sore and toxic.[each discussion] 1. " classifies herbal ": loose blood dispelling the stagnated QI, dispelling the wind and dampness pathogens bones and muscles pain, unceasing hematemesis.2. " Chinese herbal medicine is commonly used in Sichuan ": control dysmenorrhea, amenorrhea, clot, over-strained hemoptysis, rheumatic numbness, bones and muscles pain.[extracts] " China's book on Chinese herbal medicine "
Concha Solen gouldii: [source] medical material Ji Yuan: be the shell of the huge first wedge freshwater mussel of Unionidae animal or short brown lance freshwater mussel and sibling species thereof.[nature and flavor] salty in the mouth; Cool in nature.[return through] lung; Kidney channel.The expectorant of [function cures mainly] eliminating stagnation; Treating stranguria heat extraction; Cooling blood for hemostasis; Suppressing the hyperactive liver to relieve the wind syndrome.Main goiter; Phlegm retention; Gonorrhea; Metrorrhagia; Spit blood; Epistaxis; Dizzy; Tinnitus.[each discussion] 1. " herbal classic ": main whitish metrorrhagia, cold and heat, broken stranguria caused by urinary stone.2. " not Lu ": except heat between the five internal organs, Mus Xi in flesh, only stuffy sensation with restlessness, invigorating middle warmer, goes numbness of fainting, profit office.2. " detailed outline ": disappear water wart, goiter due to disorder of QI, phlegm retention.[extracts] " China's book on Chinese herbal medicine "
Radix craspedolobii schochii: [source] medical material Ji Yuan: be the root of leguminous plant Fructus Crotonis rattan.[nature and flavor] are puckery; Micro-hardship; Temperature.[return through] heart channel.[function cures mainly] promoting blood circulation and hemostasis, expelling wind and removing dampness.Main visceral hemorrhage, menoxenia, metrorrhagia, leukorrhagia, rheumatic arthralgia, traumatic injury.[extracts] " China's book on Chinese herbal medicine "
Caulis et Folium Celosiae cristatae: [source] medical material Ji Yuan: be stem and leaf or the herb of amaranthaceous plant chicken corolla flower.[nature and flavor] are sweet; Cool in nature.[function cures mainly] clearing away heat and cooling blood; Removing toxic substances.Main haematemesis; Epistaxis; Metrorrhagia; Hemorrhoid; Dysentery; Urticaria.[each discussion] 1. Compendium of Material Medica: control hemorrhoid and disorders of blood.2. " south of the Five Ridges gather medicinal herbs record ": decoct washing married woman's pudendum skin ulcer and burn.Get leaf decoction and control dysentery.[extracts] " China's book on Chinese herbal medicine "
Blood dish grass: [source] medical material Ji Yuan: for labiate Guizhou Salvia japonica Thunb. and Salvia cavaleriei are with the herb of root.[nature and flavor] mildly bitter flavor; Cool in nature.[return through] lung; Liver Channel.[function cures mainly] cooling blood for hemostasis; Promoting blood circulation and detumescence; Clearing away heat-damp and promoting diuresis.Main hemoptysis; Spit blood; Nose bleeding; Metrorrhagia; Wound hemorrhage; Traumatic pain; Carbuncle sore furuncle and phyma; Damp-heat dysentery; Leukorrhagia.[extracts] " China's book on Chinese herbal medicine "
The ratio of weight and number of the various raw medicinal materials in described Chinese medicine can more preferably: Caulis Sargentodoxae 15 ~ 25 parts, Limonitum 15 ~ 30 parts, Herba Agerati Conyzoidis 15 ~ 30 parts, Partition in Fructus Juglandis 10 ~ 25 parts, Rhizoma polygoni vivipari 15 ~ 30 parts, old cattle carries 20 ~ 30 parts, Herba asclepiadis curassaevicae 15 ~ 30 parts, european aspidium 15 ~ 25 parts, Radix Bischofiae Javanicae 10 ~ 25 parts, Rohdea japonica Roth 15 ~ 30 parts, Mnium cuspidatum Hedw. 10 ~ 30 parts, Bai Lingzi 10 ~ 25 parts, Fructus Elaeagni 15 ~ 25 parts, Radix Toddaliae Asiaticae 10 ~ 20 parts, 10 ~ 30 parts, Concha Solen gouldii, 10 ~ 25 parts, Radix craspedolobii schochii, Caulis et Folium Celosiae cristatae 10 ~ 20 parts and blood dish grass 15 ~ 25 parts.
The ratio of weight and number of the various raw medicinal materials in described Chinese medicine can also more preferably: Caulis Sargentodoxae 20 ~ 25 parts, Limonitum 15 ~ 25 parts, Herba Agerati Conyzoidis 15 ~ 20 parts, Partition in Fructus Juglandis 15 ~ 25 parts, Rhizoma polygoni vivipari 20 ~ 25 parts, old cattle carries 25 ~ 30 parts, Herba asclepiadis curassaevicae 20 ~ 30 parts, european aspidium 15 ~ 20 parts, Radix Bischofiae Javanicae 15 ~ 25 parts, Rohdea japonica Roth 20 ~ 25 parts, Mnium cuspidatum Hedw. 20 ~ 25 parts, Bai Lingzi 10 ~ 15 parts, Fructus Elaeagni 15 ~ 20 parts, Radix Toddaliae Asiaticae 15 ~ 20 parts, 20 ~ 30 parts, Concha Solen gouldii, 15 ~ 25 parts, Radix craspedolobii schochii, Caulis et Folium Celosiae cristatae 15 ~ 20 parts and blood dish grass 20 ~ 25 parts.
The ratio of weight and number of the various raw medicinal materials in described Chinese medicine also can more preferably: Caulis Sargentodoxae 23 parts, Limonitum 18 parts, Herba Agerati Conyzoidis 20 parts, Partition in Fructus Juglandis 21 parts, Rhizoma polygoni vivipari 20 parts, old cattle carry 25 parts, Herba asclepiadis curassaevicae 26 parts, european aspidium 18 parts, Radix Bischofiae Javanicae 20 parts, Rohdea japonica Roth 25 parts, Mnium cuspidatum Hedw. 23 parts, Bai Lingzi 13 parts, Fructus Elaeagni 18 parts, Radix Toddaliae Asiaticae 16 parts, 25 parts, Concha Solen gouldii, 20 parts, Radix craspedolobii schochii, Caulis et Folium Celosiae cristatae 15 parts and blood dish grass 22 parts.
The present invention further provides again a kind of preparation method of Chinese medicine of above-mentioned treatment dysfunctional uterine bleeding, and the dosage form of described Chinese medicine is granule, and it comprises the following steps:
Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 5 ~ 6 times, mixture is the ethanol of 80% ~ 95%, be heated to boiling reflux 4 ~ 6 hours, filter, take backflow as solvent, take filtering residue as solute, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.08Mpa, relative density is the mastic of 1.05 ~ 1.10, spraying dry, the inlet temperature of spray dryer 160 ~ 175 DEG C, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder,
Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 ~ 0.4 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes granule, in 40 ~ 50 DEG C of dryings, obtains granule.
The present invention further provides again a kind of preparation method of Chinese medicine of above-mentioned treatment dysfunctional uterine bleeding, and the dosage form of described Chinese medicine is syrup, and it comprises the following steps:
The first step, Caulis Sargentodoxae, Limonitum, Herba Agerati Conyzoidis, Partition in Fructus Juglandis and Rhizoma polygoni vivipari are mixed in described ratio, adding relative to the determining alcohol of 4 ~ 6 times, mixture is the ethanol of 80% ~ 90%, heating and refluxing extraction 2 ~ 4 times, each reflux, extract, 2 hours ~ 3 hours, merge extractive liquid, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 60 DEG C ~ 70 DEG C 60 DEG C, relative density is the medicinal liquid of 1.05 ~ 1.10, by dry with spray dryer for the concentrated solution after concentrated, be ground into 100 ~ 200 orders subsequently, obtain dry powder;
Second step, Herba asclepiadis curassaevicae, european aspidium, Radix Bischofiae Javanicae, Rohdea japonica Roth, Mnium cuspidatum Hedw. and Bai Lingzi are mixed in described ratio, be ground into powder, be that the ethanol of 85% ~ 95% is as solvent with determining alcohol, flood 48 hours ~ 72 hours, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being concentrated into 60 DEG C, relative density is the mastic of 1.25 ~ 1.27, dry with spray dryer, be ground into 100 ~ 200 orders subsequently, obtain dry powder, the quality of the ethanol added is 3 ~ 5 times of second step mixture quality;
3rd step, surplus stock medical material is mixed in described ratio, add relative to mixture 4 ~ 6 times amount determining alcohol be 70% ~ 80% alcohol reflux 2 ~ 4 times, each 1 hour ~ 3 hours, filter, filtrate merges, reclaim ethanol, when being concentrated into 60 DEG C, relative density is the mastic of 1.20 ~ 1.22, in 55 DEG C ~ 65 DEG C reduced vacuum dryings, obtains dry powder;
4th step, by the dry powder blend that the first step obtains to the 3rd step, add the water dissolution relative to mixture quality 3 ~ 5 times, by 40% sodium hydroxide solution adjust ph to 7.0, add correctives sucrose, antiseptic mix homogeneously subsequently, obtain syrup, the correctives added, antiseptic and the content in medicine thereof: sucrose 35 ~ 60%, Pyrusussuriensis acids antiseptic are if potassium sorbate 0.1 ~ 0.3%, paraben preservative are as ethyl hydroxybenzoate 0.01 ~ 0.05%.
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.
Embodiment 1: granule prepared by the present invention
Get Caulis Sargentodoxae 230g, Limonitum 180g, Herba Agerati Conyzoidis 200g, Partition in Fructus Juglandis 210g, Rhizoma polygoni vivipari 200g, old cattle carry 250g, Herba asclepiadis curassaevicae 260g, european aspidium 180g, Radix Bischofiae Javanicae 200g, Rohdea japonica Roth 250g, Mnium cuspidatum Hedw. 230g, Bai Lingzi 130g, Fructus Elaeagni 180g, Radix Toddaliae Asiaticae 160g, Concha Solen gouldii 250g, Radix craspedolobii schochii 200g, Caulis et Folium Celosiae cristatae 150g and blood dish grass 220g.
Its preparation method comprises the following steps:
Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 5 times, mixture is the ethanol of 85%, be heated to boiling reflux 6 hours, filter, take backflow as solvent, take filtering residue as solute, adopt percolation with the speed of 2ml per minute slowly percolation, collect percolate, when being evaporated to 55 DEG C subsequently under vacuum 0.08Mpa, relative density is the mastic of 1.05, spraying dry, the inlet temperature 165 DEG C of spray dryer, leaving air temp 85 DEG C, be ground into powder subsequently, make dried cream powder;
Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.3 times and 0.2 times in the dried cream powder obtained, makes granule, in 50 DEG C of dryings, obtains granule.
Embodiment 2: syrup prepared by the present invention
Get Caulis Sargentodoxae 250g, Limonitum 220g, Herba Agerati Conyzoidis 160g, Partition in Fructus Juglandis 180g, Rhizoma polygoni vivipari 230g, old cattle carry 280g, Herba asclepiadis curassaevicae 220g, european aspidium 170g, Radix Bischofiae Javanicae 220g, Rohdea japonica Roth 210g, Mnium cuspidatum Hedw. 240g, Bai Lingzi 120g, Fructus Elaeagni 160g, Radix Toddaliae Asiaticae 190g, Concha Solen gouldii 290g, Radix craspedolobii schochii 180g, Caulis et Folium Celosiae cristatae 170g and blood dish grass 240g.
Its preparation method comprises the following steps:
The first step, Caulis Sargentodoxae, Limonitum, Herba Agerati Conyzoidis, Partition in Fructus Juglandis and Rhizoma polygoni vivipari are mixed in described ratio, adding relative to the determining alcohol of 6 times, mixture is the ethanol of 85%, heating and refluxing extraction 3 times, each reflux, extract, 2 hours, merge extractive liquid, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 65 DEG C 60 DEG C, relative density is the medicinal liquid of 1.06, by dry with spray dryer for the concentrated solution after concentrated, be ground into 150 orders subsequently, obtain dry powder;
Second step, Herba asclepiadis curassaevicae, european aspidium, Radix Bischofiae Javanicae, Rohdea japonica Roth, Mnium cuspidatum Hedw. and Bai Lingzi being mixed in described ratio, be ground into powder, is that the ethanol of 85% is as solvent with determining alcohol, flood 60 hours, adopt percolation with the speed of 2ml per minute slowly percolation, collect percolate, when being concentrated into 60 DEG C, relative density is the mastic of 1.26, dry with spray dryer, be ground into 150 orders subsequently, obtain dry powder, the quality of the ethanol added is 4 times of second step mixture quality;
3rd step, mixes surplus stock medical material in described ratio, add relative to mixture 5 times amount determining alcohol be 75% alcohol reflux 3 times, each 2 hours, filter, filtrate merges, and reclaims ethanol, when being concentrated into 60 DEG C, relative density is the mastic of 1.20, in 60 DEG C of reduced vacuum dryings, obtains dry powder;
4th step, by the dry powder blend that the first step obtains to the 3rd step, add the water dissolution relative to mixture quality 4 times, by 40% sodium hydroxide solution adjust ph to 7.0, add correctives sucrose, antiseptic mix homogeneously subsequently, obtain syrup, the correctives added, antiseptic and the content in medicine thereof: sucrose 50%, potassium sorbate 0.25%.
Toxicity test:
Acute toxicity testing: application mice 60, male and female half and half, body weight 26-40g, carries out acute toxicity test.Mice is divided into two groups at random, i.e. matched group and administration group, before experiment, fasting 12 hours, is dissolved in water by Chinese medicine granules prepared by embodiments of the invention 1, (concentration is 8.72g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg (namely unit dosage form is 43.6 crude drugs/kg), and matched group gives normal saline, administration in one day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage granule LD50>43.6 crude drug/kg of the present invention, every day, maximum dosage-feeding was 87.2 crude drugs/kg/ day.Chinese medicine clinical application amount of the present invention be 8.26g crude drug/day/people, adult body weight in 60KG, average dosage is 0.138g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 33g) oral administration gavage Chinese medicine of the present invention is 631 times of quantity.Therefore Chinese medicine acute toxicity of the present invention is extremely low, clinical drug safety.
Long term toxicity test: Chinese medicine embodiment 1 granule of the present invention to three groups of mices (often organize 20) by 13.17,25.26 and 42.45g crude drug/kg continuous use 15 weeks (1.0ml/100g body weight, every day 2 times) and drug withdrawal after 3 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 15 weeks and drug withdrawal are after 3 weeks, and Organs of Mice is all without obviously changing.Illustrate that Chinese medicine of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.
Clinical data:
Case selection: all cases all derive from this Out-patient Department and inpatient, totally 160 examples, be divided into treatment group (80 example) and matched group (80 example) at random by medical sequencing.In treatment group 80 example, age 23-50 year; The course of disease 2 months-10 years; Unmarried 32 people, married 48 people.Matched group 80 example, age 24-53 year; The course of disease 2 months-10 years; Unmarried 31 people, married 49 people.All patients all meet the diagnostic criteria of dysfunctional uterine bleeding.Treatment group and matched group no significant difference in age, the course of disease and clinical symptoms, two groups of data comparing difference not statistically significants (P > 0.05), have comparability.
Diagnostic criteria:
Western medicine diagnose standard: menorrhagia: periods rules, but menostaxis (> 7 days) or through measuring too much (> 80ml); Through measuring too much: periods rules, menstrual period are normal, but through measuring too much; Menometrorrhagia; Cycle is irregular, menostaxis, through measuring too much; Metrorrhagia: the cycle is irregular, can extend and menstrual period not many through measuring.Possess above 1 person, namely diagnosable.
Tcm diagnosis standard: the confusion of the menstrual cycle, bleeding time length is indefinite, have last for days so that tens of day not etc., few time many during blood volume, hemorrhage often occur in short-term menolipsis after, or companion's leucorrhoea grow in quantity, the symptom such as infertile.
Exclusion standard: patient age is below 14 years old or more than 55 years old; Gestation or women breast-feeding their children; Allergic constitution or those who are allergic to this drug; Be associated with cardiovascular, liver, the serious primary disease of kidney and psychotic.
Therapeutic Method:
Treatment group: oral Chinese medicine embodiment 1 granule of the present invention, each 20g, every day 3 times.30 days courses for the treatment of, statistical result after three courses for the treatment of.
Matched group: oral Herba Clinopodii capsule (Changchun Yin Nuoke Pharmaceutical), each 4, every day 3 times.30 days courses for the treatment of, statistical result after three courses for the treatment of.
Treat and within first 1 week, stop using that all may affect the relevant medicine of test effect, and in therapeutic process, do not use medicine or the health product of other treatment dysfunctional uterine bleeding.
Curative effect judging standard: cure: after Bleeding control, continuous 3 months menstrual cycle, menstrual period and normal through measuring, recover normally to ovulate, luteal phase is no less than 12d.The only rear menopause of patient's blood premenopause, hemoglobin G reatT.GreaT.GT 100g/L, subjective symptoms disappears.Effective: after Bleeding control, menstrual cycle, menstrual period and normal through measuring, but menstrual period are still longer (7d-10d), or blood only after menopause, subjective symptoms disappears substantially, hemoglobin G reatT.GreaT.GT 100g/L.Effective: menstrual cycle, menstrual period, part subjective symptoms be improved significantly, amount of bleeding reduce, hemoglobin G reatT.GreaT.GT 80g/L.Invalid: above every all without improvement.
Therapeutic outcome: two groups treat 1 course for the treatment of respectively after, statistical result is see table 1.
Table 1 liang group treats Clinical efficacy comparison (unit: example) after 1 course for the treatment of respectively
| Group | Number of cases | Cure | Effective | Effectively | Invalid | Total effective rate |
| Treatment group | 80 | 61 | 7 | 8 | 4 | 76(95％) |
| Matched group | 80 | 39 | 12 | 16 | 13 | 67(83.75％) |
As can be seen from Table 1, adopt treatment by Chinese herbs dysfunctional uterine bleeding of the present invention, relative to matched group, on therapeutic effect, there is significant improvement.
Concrete case: patient, female, 32 years old, is diagnosed as dysfunctional uterine bleeding existing 3 years, controls for a long time and do not heal, see a doctor to the court.The granule of oral administration inventive embodiments 1, each 20g, every day 3 times, treats 3 months, and after Bleeding control, continuous 3 months menstrual cycle, menstrual period and normal through measuring, recover normally to ovulate, luteal phase is no less than 12d, cures, and follows up a case by regular visits to 6 months without recurrence.
All above-mentioned this intellectual properties of primary enforcement, not setting restriction this new product of other forms of enforcement or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.
The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.
Claims (8)
1. treat the Chinese medicine of dysfunctional uterine bleeding for one kind, it is characterized in that, described Chinese medicine comprises following raw medicinal material: Caulis Sargentodoxae, Limonitum, Herba Agerati Conyzoidis, Partition in Fructus Juglandis, Rhizoma polygoni vivipari, old cattle are carried, Herba asclepiadis curassaevicae, european aspidium, Radix Bischofiae Javanicae, Rohdea japonica Roth, Mnium cuspidatum Hedw., Bai Lingzi, Fructus Elaeagni, Radix Toddaliae Asiaticae, Concha Solen gouldii, Radix craspedolobii schochii, Caulis et Folium Celosiae cristatae and blood dish grass.
2. Chinese medicine as claimed in claim 1, it is characterized in that, the ratio of weight and number of described raw medicinal material is: Caulis Sargentodoxae 15 ~ 25 parts, Limonitum 15 ~ 30 parts, Herba Agerati Conyzoidis 15 ~ 30 parts, Partition in Fructus Juglandis 10 ~ 25 parts, Rhizoma polygoni vivipari 15 ~ 30 parts, old cattle carries 20 ~ 30 parts, Herba asclepiadis curassaevicae 15 ~ 30 parts, european aspidium 15 ~ 25 parts, Radix Bischofiae Javanicae 10 ~ 25 parts, Rohdea japonica Roth 15 ~ 30 parts, Mnium cuspidatum Hedw. 10 ~ 30 parts, Bai Lingzi 10 ~ 25 parts, Fructus Elaeagni 15 ~ 25 parts, Radix Toddaliae Asiaticae 10 ~ 20 parts, 10 ~ 30 parts, Concha Solen gouldii, 10 ~ 25 parts, Radix craspedolobii schochii, Caulis et Folium Celosiae cristatae 10 ~ 20 parts and blood dish grass 15 ~ 25 parts.
3. Chinese medicine as claimed in claim 1 or 2, it is characterized in that, the ratio of weight and number of described raw medicinal material is: Caulis Sargentodoxae 20 ~ 25 parts, Limonitum 15 ~ 25 parts, Herba Agerati Conyzoidis 15 ~ 25 parts, Partition in Fructus Juglandis 15 ~ 25 parts, Rhizoma polygoni vivipari 20 ~ 25 parts, old cattle carries 25 ~ 30 parts, Herba asclepiadis curassaevicae 20 ~ 30 parts, european aspidium 15 ~ 20 parts, Radix Bischofiae Javanicae 15 ~ 25 parts, Rohdea japonica Roth 20 ~ 30 parts, Mnium cuspidatum Hedw. 15 ~ 25 parts, Bai Lingzi 10 ~ 15 parts, Fructus Elaeagni 15 ~ 20 parts, Radix Toddaliae Asiaticae 15 ~ 20 parts, 20 ~ 30 parts, Concha Solen gouldii, 15 ~ 25 parts, Radix craspedolobii schochii, Caulis et Folium Celosiae cristatae 15 ~ 20 parts and blood dish grass 20 ~ 25 parts.
4. the Chinese medicine as described in claims 1 to 3, it is characterized in that, the ratio of weight and number of described raw medicinal material is: Caulis Sargentodoxae 23 parts, Limonitum 18 parts, Herba Agerati Conyzoidis 20 parts, Partition in Fructus Juglandis 21 parts, Rhizoma polygoni vivipari 20 parts, old cattle carry 25 parts, Herba asclepiadis curassaevicae 26 parts, european aspidium 18 parts, Radix Bischofiae Javanicae 20 parts, Rohdea japonica Roth 25 parts, Mnium cuspidatum Hedw. 23 parts, Bai Lingzi 13 parts, Fructus Elaeagni 18 parts, Radix Toddaliae Asiaticae 16 parts, 25 parts, Concha Solen gouldii, 20 parts, Radix craspedolobii schochii, Caulis et Folium Celosiae cristatae 15 parts and blood dish grass 22 parts.
5. the Chinese medicine as described in Claims 1-4, is characterized in that, the dosage form of described Chinese medicine is granule, and its preparation method comprises the following steps:
Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 5 ~ 6 times, mixture is the ethanol of 80% ~ 95%, be heated to boiling reflux 4 ~ 6 hours, filter, take backflow as solvent, take filtering residue as solute, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.08Mpa, relative density is the mastic of 1.05 ~ 1.10, spraying dry, the inlet temperature of spray dryer 160 ~ 175 DEG C, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder,
Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 ~ 0.4 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes granule, in 40 ~ 50 DEG C of dryings, obtains granule.
6. the Chinese medicine as described in Claims 1-4, is characterized in that, the dosage form of described Chinese medicine is syrup, and its preparation method comprises the following steps:
The first step, Caulis Sargentodoxae, Limonitum, Herba Agerati Conyzoidis, Partition in Fructus Juglandis and Rhizoma polygoni vivipari are mixed in described ratio, adding relative to the determining alcohol of 4 ~ 6 times, mixture is the ethanol of 80% ~ 90%, heating and refluxing extraction 2 ~ 4 times, each reflux, extract, 2 hours ~ 3 hours, merge extractive liquid, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 60 DEG C ~ 70 DEG C 60 DEG C, relative density is the medicinal liquid of 1.05 ~ 1.10, by dry with spray dryer for the concentrated solution after concentrated, be ground into 100 ~ 200 orders subsequently, obtain dry powder;
Second step, Herba asclepiadis curassaevicae, european aspidium, Radix Bischofiae Javanicae, Rohdea japonica Roth, Mnium cuspidatum Hedw. and Bai Lingzi are mixed in described ratio, be ground into powder, be that the ethanol of 85% ~ 95% is as solvent with determining alcohol, flood 48 hours ~ 72 hours, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being concentrated into 60 DEG C, relative density is the mastic of 1.25 ~ 1.27, dry with spray dryer, be ground into 100 ~ 200 orders subsequently, obtain dry powder, the quality of the ethanol added is 3 ~ 5 times of second step mixture quality;
3rd step, surplus stock medical material is mixed in described ratio, add relative to mixture 4 ~ 6 times amount determining alcohol be 70% ~ 80% alcohol reflux 2 ~ 4 times, each 1 hour ~ 3 hours, filter, filtrate merges, reclaim ethanol, when being concentrated into 60 DEG C, relative density is the mastic of 1.20 ~ 1.22, in 55 DEG C ~ 65 DEG C reduced vacuum dryings, obtains dry powder;
4th step, by the dry powder blend that the first step obtains to the 3rd step, add the water dissolution relative to mixture quality 3 ~ 5 times, by 40% sodium hydroxide solution adjust ph to 7.0, add correctives sucrose, antiseptic mix homogeneously subsequently, obtain syrup, the correctives added, antiseptic and the content in medicine thereof: sucrose 35 ~ 60%, Pyrusussuriensis acids antiseptic are if potassium sorbate 0.1 ~ 0.3%, paraben preservative are as ethyl hydroxybenzoate 0.01 ~ 0.05%.
7. a preparation method for the Chinese medicine described in Claims 1-4, is characterized in that, the dosage form of described Chinese medicine is granule, and it comprises the following steps:
Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 5 ~ 6 times, mixture is the ethanol of 80% ~ 95%, be heated to boiling reflux 4 ~ 6 hours, filter, take backflow as solvent, take filtering residue as solute, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.08Mpa, relative density is the mastic of 1.05 ~ 1.10, spraying dry, the inlet temperature of spray dryer 160 ~ 175 DEG C, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder,
Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 ~ 0.4 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes granule, in 40 ~ 50 DEG C of dryings, obtains granule.
8. a preparation method for the Chinese medicine described in Claims 1-4, is characterized in that, the dosage form of described Chinese medicine is capsule, and its preparation method comprises the following steps:
The first step, Caulis Sargentodoxae, Limonitum, Herba Agerati Conyzoidis, Partition in Fructus Juglandis and Rhizoma polygoni vivipari are mixed in described ratio, adding relative to the determining alcohol of 4 ~ 6 times, mixture is the ethanol of 80% ~ 90%, heating and refluxing extraction 2 ~ 4 times, each reflux, extract, 2 hours ~ 3 hours, merge extractive liquid, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 60 DEG C ~ 70 DEG C 60 DEG C, relative density is the medicinal liquid of 1.05 ~ 1.10, by dry with spray dryer for the concentrated solution after concentrated, be ground into 100 ~ 200 orders subsequently, obtain dry powder;
Second step, Herba asclepiadis curassaevicae, european aspidium, Radix Bischofiae Javanicae, Rohdea japonica Roth, Mnium cuspidatum Hedw. and Bai Lingzi are mixed in described ratio, be ground into powder, be that the ethanol of 85% ~ 95% is as solvent with determining alcohol, flood 48 hours ~ 72 hours, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being concentrated into 60 DEG C, relative density is the mastic of 1.25 ~ 1.27, dry with spray dryer, be ground into 100 ~ 200 orders subsequently, obtain dry powder, the quality of the ethanol added is 3 ~ 5 times of second step mixture quality;
3rd step, surplus stock medical material is mixed in described ratio, add relative to mixture 4 ~ 6 times amount determining alcohol be 70% ~ 80% alcohol reflux 2 ~ 4 times, each 1 hour ~ 3 hours, filter, filtrate merges, reclaim ethanol, when being concentrated into 60 DEG C, relative density is the mastic of 1.20 ~ 1.22, in 55 DEG C ~ 65 DEG C reduced vacuum dryings, obtains dry powder;
4th step, by the dry powder blend that the first step obtains to the 3rd step, add the water dissolution relative to mixture quality 3 ~ 5 times, by 40% sodium hydroxide solution adjust ph to 7.0, add correctives sucrose, antiseptic mix homogeneously subsequently, obtain syrup, the correctives added, antiseptic and the content in medicine thereof: sucrose 35 ~ 60%, Pyrusussuriensis acids antiseptic are if potassium sorbate 0.1 ~ 0.3%, paraben preservative are as ethyl hydroxybenzoate 0.01 ~ 0.05%.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105663860A (en) * | 2016-03-17 | 2016-06-15 | 张敏 | Traditional Chinese medicine for treating chronic viral hepatitis C and preparing method of traditional Chinese medicine |
| CN105943784A (en) * | 2016-05-17 | 2016-09-21 | 顾维乐 | Traditional Chinese medicine for treating chronic aplastic anemia and preparation method thereof |
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|---|---|---|---|---|
| CN101703614A (en) * | 2009-11-11 | 2010-05-12 | 宋爱民 | Chinese medicinal decoction for treating dysfunctional uterine bleeding |
| CN102091308A (en) * | 2011-01-19 | 2011-06-15 | 韩文正 | Medicament for treating dysfunctional uterine bleeding |
| CN102349965A (en) * | 2011-10-18 | 2012-02-15 | 文登市口腔医院 | Traditional Chinese medicine for treating dysfunctional uterine bleeding |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101703614A (en) * | 2009-11-11 | 2010-05-12 | 宋爱民 | Chinese medicinal decoction for treating dysfunctional uterine bleeding |
| CN102091308A (en) * | 2011-01-19 | 2011-06-15 | 韩文正 | Medicament for treating dysfunctional uterine bleeding |
| CN102349965A (en) * | 2011-10-18 | 2012-02-15 | 文登市口腔医院 | Traditional Chinese medicine for treating dysfunctional uterine bleeding |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105663860A (en) * | 2016-03-17 | 2016-06-15 | 张敏 | Traditional Chinese medicine for treating chronic viral hepatitis C and preparing method of traditional Chinese medicine |
| CN105943784A (en) * | 2016-05-17 | 2016-09-21 | 顾维乐 | Traditional Chinese medicine for treating chronic aplastic anemia and preparation method thereof |
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