CN104689279A - Traditional Chinese medicine preparation for adenomyosis of uterus and preparation method thereof - Google Patents
Traditional Chinese medicine preparation for adenomyosis of uterus and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine preparation for adenomyosis of uterus. The traditional Chinese medicine preparation for the adenomyosis of uterus is prepared by taking astragalus membranaceus, radix paeoniae rubra, earthworm, ligusticum wallichii, fennel, dried ginger, angelica sinensis, peach kernel, flos carthami, fructus aurantii, corydalis tuber, trogopterus dung, cortex moutan, lindera aggregata, rhizome cyperi, Szechwan chinaberry fruit, pollen typhae, scorpion, rhizome sparganii, curcuma zedoary, resina draconis, pangolin and spina gleditsiae as the raw medicines, preprocessing the raw medicines through cleaning and slicing according to different characteristics of the raw medicines, and performing proportional preparation and manufacturing through a special method. The traditional Chinese medicine for the adenomyosis of uterus achieves the effects of soothing the liver, regulating qi, promoting blood circulation, removing blood stasis, eliminating pathogens, strengthening body energy, warming channels and expelling cold. The traditional Chinese medicine preparation for the adenomyosis of uterus is unique in composition and manufacturing method, and through clinical verification, is significant in treating effects, short in treatment cycle, low in price and free from toxic and side effects, thereby having a wide market application prospect.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation, be specifically related to a kind of Chinese medicine preparation for adenomyosis, the invention still further relates to the preparation method of this Chinese medicine preparation.
Background technology
Adenomyosis (adenomyosis) is that endometrial gland and the formation of interstitial intrusion myometrium are filled the air or circumscribed pathological changes; along with compensatory hypertrophy and the hypertrophy of around muscle layer cell; for a kind of estrogen-dependent diseases; it is common gynecological disease; it usually can cause the symptom such as secondary dysmenorrhea and hyper-menorrhea, thus has a strong impact on the physical and mental health of women.Adenomyosis in the past multiple being born in is sent out in the Women of Childbearing Age of 30 ~ 50 years old, and overall incidence is 5%-70%.But in recent years in rejuvenation trend gradually, this may be relevant to the increasing of performing the operation such as Cesarean esction, artificial abortion.Cardinal symptom shows as: (1) menoxenia (40-50%): main manifestations is menostaxis, hyper-menorrhea, and some patients also may occur that before and after menstruation, drop is hemorrhage.This is because uterine volume increases, cavity of uterus Intimal area increases and between uterine muscular, focus affects the initiation of uterus muscle filament contraction.Serious patient can cause anemia.(2) dysmenorrhea (25%): feature is the dysmenorrhea that Secondary cases Progressive symmetric erythrokeratodermia increases the weight of.Menstrual onset of being everlasting to start to occur the last week, namely alleviates when menstrual period terminate dysmenorrhea.This is because ectopic endometrium during menstruation in myometrium is congested under the impact of ovarian hormone, swelling and hemorrhage, also add the blood volume of myometrial blood vessel simultaneously, make hard thick myometrium expansion, cause serious dysmenorrhea.(3) patient's non-evident sympton of nearly 35%.
The traditional Chinese medical science is thought, motherland's medical science there is no this name of disease to adenomyosis and records.According to its cardinal symptom and sign performance, the traditional Chinese medical science " dysmenorrhea ", “ mass in the abdomen can be belonged to ", " menoxenia ", the disease category such as " infertile ".According to the research of modern Chinese medicine, the etiology and pathogenesis of adenomyosis can be summarized as follows substantially: exopathogenic factor mostly is wind and cold or damp and hot heresy is tied mutually with QI and blood, causes QI-blood circulation and is obstructed and sends out as adenomyosis; Endogenous cause of ill mostly is disorder of emotion, the stagnation of QI, or internal organs disorder of QI and blood, thus causes " pathogen is come and gone, and amasss the moon day and gathers, whole extremely gradually Yi Cheng Disorder ", therefore on pathogenesis: the key that " stopping in blood stasis " is primary disease.
Doctor trained in Western medicine AM western medical treatment method mainly divides Drug therapy and operative treatment clinically at present, and Drug therapy mainly suppresses estrogen secretion, creates the environment of a low estrogen to reach the object suppressing disease progression.Though hormone therapy energy relief of symptoms, directly affects patient's endocrine function, also can affect bone metabolism, damage liver function, unsuitable Long-term taking medicine, after drug withdrawal, relapse rate is high.Uterine cavity places the graceful moon happy (levonorgestrel-releasing intrauterine system) conduct this disease of western medical treatment comparatively effective measures in recent years, its principle is the expression by suppressing estrogen receptor in uterus film at uterine cavity local slow release levonorgestrel, thus antagonism neointimal hyperplasia, menstrual blood volume is obviously reduced, relieving dysmenorrhea.But place the graceful moon happy after still to there is a series of untoward reaction light, comprise that drop is hemorrhage, amenorrhea, decylization, ring displacement, tenderness of breasts and ovarian cyst etc., limit it in clinical extensive utilization.Operative treatment mode is divided into radical surgery and conservative operation dealing, to youth, has the fertility feasible conservative surgeries in treating of patient requests and AM lesion resection art, but conservative surgeries in treating existence thoroughly can not remove focus and the problems such as recurrence after operation rate height.To atoke requirement, and pathological changes extensively, severe symptoms, expectant treatment nonresponder, panhysterectomy is the most frequently used method, is also the means uniquely effecting a radical cure this disease.But, a series of complication can be produced after hysterectomy, comprise surrounding organ damage, Massive Bleeding, postoperative infection and ovarian function and reduce the perimenopausal symptom (hectic fever, irritability, anxiety, depression etc.) caused.Along with the raising that progress and the people of society required quality of life, find new more effective and the Therapeutic Method of Reservations uterus is very necessary.As everyone knows, Chinese medicine is in the advantage of alleviating pain, regulating menstruation and assisting pregnancy, its uniqueness of improving the quality of living, all have in side effect is little, late result is stablized etc.
Summary of the invention
The object of the present invention is to provide a kind of Chinese medicine preparation being used for the treatment of adenomyosis, it is remarkable that this Chinese medicine preparation has therapeutic effect for treatment adenomyosis, and healing time is short, cheap, has no adverse reaction and the feature of secondary toxic action.
Inventor is in clinical treatment practice for many years, and according to the law of development of this disease, and the combination principle of Chinese medicine, and by a large amount of clinical verifications, Exploration and conclusion goes out to be used for the treatment of the new formula of the Chinese medicine preparation of adenomyosis repeatedly.The present invention has that therapeutic effect is remarkable, and healing time is short, cheap, has no adverse reaction and the feature of secondary toxic action.
The effect of Chinese medicine of the present invention:
Wherein: the Radix Astragali: be the dry root of leguminous plant Radix Astagali Astragalus membranaceus (Fisch.) Bge.var.mongholicus (Bge.) Hsiao or Radix Astragali Astragalus membranaceus (Fisch.) Bge..Nature and flavor: sweet, temperature.Return lung, spleen channel.Effect: invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.Weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle difficulty is burst, and burst for a long time and do not hold back, blood deficiency dull yellowish colored skin, interior-heat is quenched one's thirst; Chronic nephritis proteinuria, diabetes.
Radix Paeoniae Rubra: be the dry root of ranunculaceae plant Radix Paeoniae Paeonia lactiflora Pall. or river Radix Paeoniae Rubra Paeonia veitchii Lynch.Nature and flavor: bitter, are slightly cold.Return Liver Channel.Effect: clearing away heat and cooling blood, eliminating stasis to stop pain.For maculae caused by violent heat pathogen, hematemesis and epistaxis, conjunctival congestion and swelling pain, hypochondriac pain due to stagnation of liverQI, amenorrhea dysmenorrhea, lump in the abdomen is suffered from abdominal pain, injury from falling down, carbuncle skin infection.TAO Hong-Jing is said: " the red person's minor benefit of Radix Paeoniae, custom side, with pain relieving, is do not subtract Radix Angelicae Sinensis ".
Pheretima: be the dry body of Ju Yin section animal Pheretima aspergillum Pheretima aspergillum (E.Perrier), popular Pheretimatschiliensis Pheretima vulgaris Chen, power simulation Pheretima guillelmi (Michaelsen) or comb blind Pheretimatschiliensis Pheretima pectinifera Michaelsen.Nature and flavor: salty, cold.Return liver, spleen, urinary bladder channel.Effect: heat clearing away is calmed the frightened, and dredging collateral, relievings asthma, diuresis.For unconsciousness due to high fever, infantile convulsion is twitched, arthralgia, numb limbs and tense tendons, hemiplegia, dyspnea and cough due to lung-heat, oliguria edema, hypertension.
Rhizoma Chuanxiong: be the dry rhizome of samphire Rhizoma Chuanxiong Ligusticum chuanxiong Hort. (or Ligusticum wallichiiFranch.).Nature and flavor: pungent, temperature.Return liver, gallbladder, pericardium channel.Effect: blood-activating and qi-promoting, wind-expelling pain-stopping.For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen is suffered from abdominal pain, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia.Record in " Japan hanako materia medica ": control a wind cutting, all gas, all strains, all blood, mend five kinds of over strain, strengthening bone and muscle, adjusts many arteries and veins, and broken Disorder ties stagnated blood, supports fresh blood, puts on flesh, serious epistaxis, spits blood and hematuria, hemorrhoid complicated by anal fistula, brain carbuncle carbuncle on the back, and scrofula wart is gone to live in the household of one's in-laws on getting married, skin ulcer scabies, and evacuation of pus repercussive blood.
Fructus Foeniculi: be the dry mature fruit of samphire Fructus Foeniculi Foeniculum vulgare Mill..Nature and flavor: pungent, temperature.Return liver,kidney,spleen, stomach warp.Effect: dispersing cold for relieving pain, regulating qi-flowing for harmonizing stomach.For colic of cold type stomachache, the testis swelling and hanging down of either of the testes, dysmenorrhea, few abdomen cold type of pain, abdominal distention, lack of appetite and vomiting, hydrocele of testis.Salt Fructus Foeniculi warming the kidney dispersing cold for relieving pain.For colic of cold type stomachache, the testis swelling and hanging down of either of the testes, through cold stomachache.
Rhizoma Zingiberis: be the dry rhizome of zingiber Zingiber officinale Rosc..Nature and flavor: pungent, hot.Return spleen, stomach, kidney, the heart, lung meridian.Effect: Rhizoma Zingiberis warming spleen and stomach for dispelling cold, recuperating depleted YANG is promoted blood circulation, dampness expectorant.For coldness and pain in the epigastrium, vomiting is had loose bowels, and cold extremities faint pulse, phlegm retention is breathed with cough.Record in " detailed outline ": Rhizoma Zingiberis, can draw that blood medicine enters blood system, gas medicine enters edema caused by disorder of QI.Can go again to dislike and support newly, have the meaning of Yin grows while yang is generating.
Radix Angelicae Sinensis: be the dry root of umbelliferae angelica Angelica sinensis (Oliv.) Diels.Nature and flavor: sweet, acrid, warm.Return liver, the heart, spleen channel.Effect: enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.For blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.Radix Angelicae Sinensis (processed with wine) promoting blood circulation to restore menstrual flow.For amenorrhea dysmenorrhea, rheumatic arthralgia, injury from falling down.Record in " not Lu ": warming middle-JIAO to relieve pain, fill in except in objective blood, middle puerperal tetanus, no sweating, arthralgia chiefly caused by damp pathogen, attacked by pestiferous factors is courteous, cold caused by deficiency, mend five and hide, granulation promoting meat.
Semen Persicae: be the dry mature seed of rosaceous plant Fructus Persicae Prunus persica (L.) Batsch or Prunus davidiana Prunus davidiana (Carr.) Franch..Nature and flavor: bitter, sweet, flat.GUIXIN, liver, large intestine channel.Effect: blood circulation promoting and blood stasis dispelling, loosening bowel to relieve constipation.For amenorrhea, dysmenorrhea ， mass in the abdomen mass in the abdomen, injury from falling down, dryness of the intestine constipation.Record in " herbal classic ": main blood stasis, blood closes lump in the abdomen, pathogen, kills small worm." not Lu ": only cough with dyspnea, disappear hardness in the epigastrium, and except soldier hits blood cruelly, broken lump in the abdomen, promotes blood circulation, pain relieving.
Flos Carthami: be the dried floral of feverfew Flos Carthami Carthamus tinctorius L..Nature and flavor: pungent, temperature.GUIXIN, Liver Channel.Effect: promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain.For amenorrhea, dysmenorrhea, lochia, lump in the abdomen mass in the abdomen, injury from falling down, skin infection swells and ache." detailed outline ": invigorate blood circulation, moisturizes, pain relieving, loose swollen, stimulates the menstrual flow.
Fructus Aurantii: be the dry immature fruit of rutaceae Citrus aurantium Linn. Citrus aurantium L. and variety thereof.Nature and flavor: bitter, pungent, sour, temperature.Return spleen, stomach warp.Function cures mainly: regulating the flow of QI to ease the stomach, the stagnant relieving distension of row.For the breast side of body stagnation of QI, distension pain, accumulation of food in the stomach and intes tine due to indigestion, stops in phlegm retention; Gastroptosis, proctoptosis, sub-official's prolapsus.Record in " Japan hanako materia medica ": spleen benefiting and stimulating the appetite, adjust the five internal organs, the therapeutic method to keep the adverse QI flowing downwards, preventing or arresting vomiting is inverse, expectorant.
Rhizoma Corydalis: be the dry tuber of papaveraceae plant corydalis Corydalis yanhusuo W.T.Wang.Nature and flavor: pungent, bitter, temperature.Return liver, spleen channel.Effect: invigorate blood circulation, promoting the circulation of QI, pain relieving.For the breast side of body, epigastric pain, amenorrhea dysmenorrhea, postpartum stagnation, tumbling and swelling.Record in " Japan hanako materia medica ": except wind, control gas, warm waist knee joint, broken disease addiction, flutter damage blood stasis, fall tire, and sudden and violent lumbago.
Oletum Trogopterori: be flying squirrel section animal trogopterus xanthipes Trogopterus Xanthipes Milne-Edwards or the dry feces flying murine little flying squirrel Pteromys volans L..Nature and flavor: sweet, temperature.Effect: promoting blood circulation to remove blood stasis, parch to black stops blooding.Have a pain for trusted subordinate's congestion, dysmenorrhea, blood stasis amenorrhea, puerperal abdominalgia with blood stasis; Parch to black controls metrostaxis; Traumatic injury is controlled in external, Serpentis, insect bite wound.Record in " Amplification on Materia Medica addendum ": can promoting the circulation of blood hemostasis.Control trusted subordinate's cold air, married woman is pained, pricking caused by the stagnation of QI and blood.
Cortex Moutan: be the dry root bark of ranunculaceae peony Paeonia suffruticosa Andr..Nature and flavor: bitter, pungent, are slightly cold.GUIXIN, liver, kidney channel.Effect: clearing away heat and cooling blood, blood circulation promoting and blood stasis dispelling.For maculae caused by violent heat pathogen, hematemesis and epistaxis, night fever abating at dawn, lossless hectic fever due to YIN-deficiency, amenorrhea dysmenorrhea, carbuncle sore tumefacting virus, falls and flutters the pain of injury.Record in " Japan hanako materia medica ": except pathogen, happy color, clearance natural fibre line of meat blood vessels, evacuation of pus, logical menstruation, disappear and flutter damage blood stasis, reuniting the fractured tendons and bones, except migratory arthralgia, fall tire lower eyelid, puerperal all cold and hot vim and vigour.
The Radix Linderae: be the dried root of canella Radix Linderae Lindera aggregata (Sims) Kosterm..Nature and flavor: pungent, temperature.Return lung, spleen, kidney, urinary bladder channel.Effect: pleasant pain relieving, warming kidney for dispelling cold.For chest and abdomen swelling and pain, QI rising in reverse order dyspnea with rapid respiration, deficiency-cold in the urinary bladder, enuresis frequent micturition, hernia, dysmenorrhea.Record in " explaining abstruseness of the canon of materia medica ": the pent-up of reason seven emotions, QI and blood is solidifying stops, and cholera is vomited and diarrhoea, and expectorant food is delaied.
Rhizoma Cyperi: be the dry rhizome of sedge dried tuber Cyperus rotundus L..Nature and flavor: pungent, micro-hardship, micro-sweet are flat.Return liver, spleen, tri-jiao channel.Effect: promoting QI circulation for relieving depression, menstruction regulating and pain relieving.For stagnation of QI due to depression of the liver, breast, the side of body, abdominal distention, dyspepsia, breast gastral cavity painful abdominal mass is vexed, and colic of cold type is suffered from abdominal pain, distending pain of the breast, menoxenia, amenorrhea dysmenorrhea.Record in " detailed outline ": loose seasonal epidemic pathogens is trembled with fear epidemic disease, and profit three is burnt, and separate six kinds of stagnation-syndromes, the diet that disappears gathers, phlegm retention feeling of fullness, edema of dorsum of the foot, abdominal distention, beriberi, only trusted subordinate, limbs, head, order, tooth, all pains of ear, ulcer sores, spits blood, hematochezia, hematuria, married woman's bleeding not during menses, the moon wait uncomfortable, before tire puerperal all kinds of diseases and ailments.
Fructus Toosendan: be the dry mature fruit of Meliaceae plant Fructus Toosendan Melia toosendan Sieb.et Zucc..Nature and flavor: bitter, cold; Slightly poisonous.Return liver, small intestinal, urinary bladder channel.Effect: soothing liver-QI promoting the circulation of QI to relieve pain, anthelmintic.For the breast side of body, abdominal distention, colic, abdominal pain due to worm stagnation.Record in " medical center bun is wanted ": eliminating heart-fire, hard kidney water, lung heat clearing gold, clearing away liver-fire.Core: happy hernia, removes syndrome of aversion to cold lasting day and night with cold limbs.
Pollen Typhae: be the dry pollen of Typhaceae vegetation water turbid Herba Typhae Typha angustifolia L., typha orientalis Typhaorientalis Presl or congener.Nature and flavor: sweet are flat.Return liver, pericardium channel.Effect: hemostasis, blood stasis dispelling, treating stranguria.For spitting blood, epistaxis, spitting of blood, metrorrhagia, traumatic hemorrhage, amenorrhea dysmenorrhea, gastral cavity ventral spine pain, tumbling and swelling, blood strangury and dry pain.Record in " property of medicine opinion ": qualcomm meridian, only woman's metrorrhagia incessantly, main dysentery blood, and only epistaxis, controls hematuria, dredging water passages.
Scorpio: be the dry body of Buthidae animal Scorpio Buthus martensii Karsch.Nature and flavor: pungent are flat.Return Liver Channel.Effect: endogenous wind stopping spasmolytic, dispersing pathogen accumulation, removing obstruction in the collateral to relieve pain.For infantile convulsion, tic spasm, middle air port is askew, hemiplegia, tetanus, rheumatoid arthritis stubborn, migraine and general headache, skin infection, scrofula.Record in " detailed outline ": control adult Xuan malaria, deaf, hernia, all wind skin ulcers, woman's leukorrhagia, prolapse of the uterus.
Rhizoma Sparganii: be the dry tuber of Sparganiaceae plant rhizoma scirpi Sparganium stoloniferum Buch.-Ham..Nature and flavor: pungent, bitter are flat.Return liver, spleen channel.Effect: removing blood stasis circulation of qi promoting, removing food stagnancy pain relieving.For lump in the abdomen mass in the abdomen, blood stasis amenorrhea, food stagnation distending pain.Record in " Japan hanako materia medica ": control married woman's blood vessels uncomfortable, cardiac and abdominal pain, fall tire, and disappear stagnant blood, mend labor, logical menstruation, controls flatulence, disappears and flutter damage blood stasis, puerperal abdonimal pain, blood fortune stagnated blood not under.
Rhizoma Curcumae: be the dry rhizome of zingiberaceous plant Rhizoma Curcumae Curcuma phaeocaulis Val., Guangxi zedoary CurcumaKwangsiensis S.G.Lee et C.F.Liang or RADIX CURCUMAE Curcuma wenyujin Y.H.Chenet C.Ling.Nature and flavor: pungent, bitter, temperature.Return liver, spleen channel.Effect: circulation of qi promoting removing blood stasis, removing food stagnancy pain relieving.For Dan abdominal mass mass in the abdomen, blood stasis amenorrhea, food stagnation distending pain; Early cervical carcinoma.
Sanguis Draxonis: the resin oozed out for babassu Sanguis Draxonis Daemonorops draco Blume. fruit is through being processed into.Nature and flavor: sweet, salty are flat.GUIXIN, Liver Channel.Effect: removing blood stasis and relieving pain, hemostasia and promoting granulation.Lose for falling to flutter, ecchymoma due to internal injury; Continuous bleeding due to traumatic injury.Record in " Haiyao Bencao, Oversea Materia Medica ": leadingly traumatic fracture damage, all pain, tonify deficiency and vim and vigour stir thorn, and interior blood trouble is gathered, and should wine clothes.
Squama Manis: be the scute of Manidae animal Squama Manis Manis pentadactyla Linnaeus.Nature and flavor: salty, are slightly cold.Return liver, stomach warp.Effect: stimulating milk secretion of stimulating the menstrual flow, detumescence and apocenosis, expel wind to dredge collateral.For amenorrhea and mass in the abdomen, galactostasis, carbuncle sore tumefacting virus, arthralgia, numbness contracture.Record in " detailed outline ": except intermittent fever due to phlegm cold and heat, the tetanic pain of migratory arthralgia, qualcomm meridian, lower milk, subduing inflammation, evacuation of pus blood, sensible parasite killing.
Spina Gleditsiae: be the dry Spina jujubae of leguminous plant Fructus Gleditsia Gleditsia sinensis Lam..Nature and flavor: pungent, temperature.Return liver, stomach warp.Effect: detumescence poison holding, evacuation of pus, parasite killing.For carbuncle from the beginning of or difficulty in discharging of pus; External treatment scabies leprosy.Record in " detailed outline ": control carbuncle, acute mastitis, scrofula caused by pathogenic wind malignant boil, retention of placenta, parasite killing.
Side's solution of the present invention is: the Radix Astragali, Rhizoma Chuanxiong, Radix Angelicae Sinensis, Semen Persicae, Flos Carthami, Oletum Trogopterori, Cortex Moutan, the Radix Linderae have depressed liver-energy dispersing and QI regulating, nourshing blood and promoting blood circulation effect.Adenomyosis pathological changes etiology and pathogenesis main cause is blood stasis, liver storing blood, and depression of liver-QI, catharsis are not normal, so that mechanism of qi retardance, perverse and unreasonable manner violate stomach, qi disease involving blood, thrombosis and cost disease.Above eight taste medicines are energy depressed liver-energy dispersing and QI regulating, nourshing blood and promoting blood circulation all.As monarch drug in side, first fundamentally depressed liver-energy dispersing and QI regulating, nourshing blood and promoting blood circulation, makes disease obtain basic control.Fructus Foeniculi, Rhizoma Zingiberis, Fructus Aurantii, Rhizoma Corydalis, Rhizoma Cyperi, Fructus Toosendan, Scorpio, Rhizoma Sparganii, Rhizoma Curcumae, Sanguis Draxonis have eliminating pathogenic factor for supporting vital QI, dispelling cold by warming the meridian, the primary disease traditional Chinese medical science says that exopathogenic factor mostly is wind and cold or damp and hot heresy is tied mutually with QI and blood, causes QI-blood circulation and is obstructed and sends out as adenomyosis; Endogenous cause of ill mostly is disorder of emotion, the stagnation of QI, or internal organs disorder of QI and blood, thus causes " pathogen contact, amasss the moon day and gather, whole extremely gradually Yi Cheng Disorder ", and above ten taste medicines, as ministerial drug, assist monarch drug depressed liver-energy dispersing and QI regulating, nourshing blood and promoting blood circulation on the one hand; Itself as ministerial drug, there is eliminating pathogenic factor for supporting vital QI, dispelling cold by warming the meridian on the other hand.Radix Paeoniae Rubra, Pheretima, Pollen Typhae, Squama Manis, the above five kinds of Chinese medicine of Spina Gleditsiae have detumescence dissipating blood stasis analgesic efficacy, smooth to the tune of whole body mechanism of qi, the mediation of QI and blood, plays important regulating action, as auxiliary monarch-minister drug depressed liver-energy dispersing and QI regulating, the nourshing blood and promoting blood circulation on the one hand of the adjuvant drug in prescription; Assist ministerial drug eliminating pathogenic factor for supporting vital QI, dispelling cold by warming the meridian on the other hand.The all medicines of this side share, and the monarch and his subjects pull together, and minister assistant shares, and has effect of depressed liver-energy dispersing and QI regulating, blood circulation promoting and blood stasis dispelling, eliminating pathogenic factor for supporting vital QI, dispelling cold by warming the meridian, effectively can treat adenomyosis.
Medicine material consumption of the present invention is groped to sum up to draw through inventor in a large number, each raw material dosage is for all to have good curative effect in following weight parts scope: the Radix Astragali 28 ~ 32g, Radix Paeoniae Rubra 13 ~ 17g, Pheretima 18 ~ 22g, Rhizoma Chuanxiong 8 ~ 12g, Fructus Foeniculi 13 ~ 17g, Rhizoma Zingiberis 13 ~ 17g, Radix Angelicae Sinensis 18 ~ 22g, Semen Persicae 13 ~ 17g, Flos Carthami 13 ~ 17g, Fructus Aurantii 13 ~ 17g, Rhizoma Corydalis 13 ~ 17g, Oletum Trogopterori 13 ~ 17g, Cortex Moutan 8 ~ 12g, the Radix Linderae 13 ~ 17g, Rhizoma Cyperi 13 ~ 17g, Fructus Toosendan 13 ~ 17g, Pollen Typhae 13 ~ 17g, Scorpio 4 ~ 8g, Rhizoma Sparganii 13 ~ 17g, Rhizoma Curcumae 13 ~ 17g, Sanguis Draxonis 13 ~ 17g, Squama Manis 13 ~ 17g, Spina Gleditsiae 18 ~ 22g.
Wherein be preferably: Radix Astragali 30g, Radix Paeoniae Rubra 15g, Pheretima 20g, Rhizoma Chuanxiong 10g, Fructus Foeniculi 15g, Rhizoma Zingiberis 15g, Radix Angelicae Sinensis 20g, Semen Persicae 15g, Flos Carthami 15g, Fructus Aurantii 15g, Rhizoma Corydalis 15g, Oletum Trogopterori 15g, Cortex Moutan 10g, Radix Linderae 15g, Rhizoma Cyperi 15g, Fructus Toosendan 15g, Pollen Typhae 15g, Scorpio 6g, Rhizoma Sparganii 15g, Rhizoma Curcumae 15g, Sanguis Draxonis 15g, Squama Manis 15g, Spina Gleditsiae 20g.
A kind of preparation method of the Chinese medicine preparation for adenomyosis is as follows:
Step one: by weight of the present invention, get clean Squama Manis according to boiling hot method stir-baking in sand to heaving, cleaning, drying, smash to pieces, for subsequent use; Get clean Oletum Trogopterori and put into the micro-stir-fry of pot, spray rice wrong, fry to surperficial glossy time take out, dry, for subsequent use; Get Pollen Typhae and cross 100 mesh sieves, with gauze wrapping, for subsequent use; Get clean Sanguis Draxonis powder breakdown mill and cross 100 mesh sieves, for subsequent use; Get clean Flos Carthami gauze to wrap up, for subsequent use;
Step 2: by weight proportion of the present invention, gets the Radix Astragali, Radix Paeoniae Rubra, Rhizoma Chuanxiong, Radix Angelicae Sinensis, Fructus Aurantii, Rhizoma Corydalis, Cortex Moutan, the Radix Linderae, Rhizoma Cyperi, Fructus Toosendan, Rhizoma Sparganii, Rhizoma Curcumae, Spina Gleditsiae removing impurity, cleans, run through, section, dry, for subsequent use; Get Pheretima, Fructus Foeniculi, Rhizoma Zingiberis, Semen Persicae, Scorpio removing impurity, clean, cut 0.5-1cm section, dry, for subsequent use;
Step 3: by weight proportion of the present invention, by step one and the step 2 Chinese crude drug Radix Astragali, Radix Paeoniae Rubra, Pheretima, Rhizoma Chuanxiong, Fructus Foeniculi, Rhizoma Zingiberis, Radix Angelicae Sinensis, the Radix Linderae, Rhizoma Cyperi, Scorpio, Rhizoma Sparganii, Rhizoma Curcumae, Squama Manis, Spina Gleditsiae medical material is placed in marmite, add the water of 8 times of volumes, intense fire infusion 10 ~ 15 minutes, fiery infusion of larding speech with literary allusions is filtered for 20 ~ 30 minutes, add the water of 3 times of volumes again, by Fructus Aurantii, Rhizoma Corydalis, Oletum Trogopterori, Cortex Moutan, Fructus Toosendan drops in marmite, slow fire infusion 10 ~ 15 minutes, finally by Semen Persicae, Flos Carthami, Pollen Typhae, Sanguis Draxonis drops into marmite slow fire infusion 10 ~ 15 minutes, infusion merges gained filtrate three times repeatedly, for subsequent use,
Step 4: by step 3 gained filtrate sealing preserve, both Chinese medicine decoction of the present invention.Using method of the present invention: get decoction warm, every day 3 times.It within 7 days, is a course for the treatment of.
Medicine of the present invention has the effect of depressed liver-energy dispersing and QI regulating, blood circulation promoting and blood stasis dispelling, eliminating pathogenic factor for supporting vital QI, dispelling cold by warming the meridian, and it is effective, cheap, have no side effect, easy to use, the mode that this Chinese medicine preparation adopts is treated and can be reduced Western medicine and the injury of operation to patient body, alleviate the slight illness of patient, according to clinical 240 routine patient view statistics, use medicine of the present invention the total effective rate course for the treatment of 82.5%, two the total effective rate course for the treatment of 95%.
Detailed description of the invention
Embodiment one: Radix Astragali 30g, Radix Paeoniae Rubra 15g, Pheretima 20g, Rhizoma Chuanxiong 10g, Fructus Foeniculi 15g, Rhizoma Zingiberis 15g, Radix Angelicae Sinensis 20g, Semen Persicae 15g, Flos Carthami 15g, Fructus Aurantii 15g, Rhizoma Corydalis 15g, Oletum Trogopterori 15g, Cortex Moutan 10g, Radix Linderae 15g, Rhizoma Cyperi 15g, Fructus Toosendan 15g, Pollen Typhae 15g, Scorpio 6g, Rhizoma Sparganii 15g, Rhizoma Curcumae 15g, Sanguis Draxonis 15g, Squama Manis 15g, Spina Gleditsiae 20g.
Embodiment two: Radix Astragali 31g, Radix Paeoniae Rubra 15g, Pheretima 20g, Rhizoma Chuanxiong 10g, Fructus Foeniculi 15g, Rhizoma Zingiberis 16g, Radix Angelicae Sinensis 22g, Semen Persicae 15g, Flos Carthami 15g, Fructus Aurantii 15g, Rhizoma Corydalis 16g, Oletum Trogopterori 15g, Cortex Moutan 11g, Radix Linderae 15g, Rhizoma Cyperi 15g, Fructus Toosendan 16g, Pollen Typhae 14g, Scorpio 6g, Rhizoma Sparganii 15g, Rhizoma Curcumae 15g, Sanguis Draxonis 15g, Squama Manis 16g, Spina Gleditsiae 20g.
Embodiment three: Radix Astragali 30g, Radix Paeoniae Rubra 17g, Pheretima 21g, Rhizoma Chuanxiong 11g, Fructus Foeniculi 15g, Rhizoma Zingiberis 17g, Radix Angelicae Sinensis 21g, Semen Persicae 15g, Flos Carthami 15g, Fructus Aurantii 15g, Rhizoma Corydalis 15g, Oletum Trogopterori 15g, Cortex Moutan 9g, Radix Linderae 15g, Rhizoma Cyperi 15g, Fructus Toosendan 15g, Pollen Typhae 15g, Scorpio 5g, Rhizoma Sparganii 15g, Rhizoma Curcumae 16g, Sanguis Draxonis 16g, Squama Manis 16g, Spina Gleditsiae 21g.
Here is the clinical statistics data that patient uses medicine of the present invention:
Physical data
One, accept out-patient 240 example for medical treatment, patient is divided into observation group and matched group at random, max age 45 years old, minimal ages 30 years old, course of disease some months is not by several years etc.Every basic documents such as two groups of patient ages, sex, courses of disease are substantially identical, no significant difference (P > 0.05).
Two, tcm diagnosis standard
1, qi stagnation and blood stasis type adenomyosis: menstrual period lower abdominal distention pain or spasmic pain, violent tenderness, susceptible to lose temper due to restlessness, breast side of body distending pain of the breast, menorrhagia, has block, or extends through line time, and uterus increases, and body of the tongue is purple, or has petechia, stringy and hesitant pulse.
2. cold blood stasis type adenomyosis: lower abdominal colic during menstruation or cold type of pain, tenderness, pain alleviated while getting warmth, menorrhagia, color is purple dark, and have block, aversion to cold and cold limbs, dark tongue quality has petechia, deep and tense pulse.
3. expectorant blood stasis type adenomyosis: menstrual period lower abdomen pain with tenderness, menorrhagia, matter is rare as water, has clot, and uterus increases, chest distress, vomiting and nausea tending to vomit, profuse leukorrhea, and color is white, and matter is thick, and dark tongue quality tongue is greasy in vain, deep-rolling pulse and string.
Three, Therapeutic Method:
1, observation group is according to Medications Example one of the present invention, weighting raw materials (daily dose), and by the treatment of invention implementation method, getting decoction warm, one day three times, 7th is a course for the treatment of.
2, matched group adopts conventional western medicine medication treatment method, and the Ureteral Calculus phase is 7 days.
Four, efficacy assessment standard:
1, cure: clinical symptom disappearance, the eumenorrhea, through amount and time normally, do not recur in 1 year.
2, take a turn for the better: clinical symptom disappearance, the eumenorrhea, menstrual blood volume is more, and gynaecological examination is obviously improved, normal after two months, does not recur in 1 year.
3, invalid: to no effect.Clinical symptoms does not disappear.
Five, therapeutic outcome statistics:
Matched group result is added up
Use the Comparison of therapeutic situation of this Chinese medicine preparation two groups of patients, two courses for the treatment of
| Group | Number of cases | Cure [n (%)] | Take a turn for the better [n (%)] | Invalid [n (%)] | Total effective rate (%) |
| Observation group | 120 | 81(67.5) | 33(27.5) | 6(5) | 95 |
| Matched group | 120 | 60(50) | 40(33.3) | 20(16.7) | 83.3 |
Wherein: total effective rate=cure rate+improvement rate
Can find that observation group is apparently higher than matched group by the treatment total effective rate contrasting two groups of patients, illustrate thus, Chinese medicine of the present invention to cause in amenorrhea because suffering from cold anger treatment women has good clinical effectiveness, effectively can improve the cure rate for the treatment of, Be very effective, cycle is short, without any side effects, has wide market application foreground.
Model case and curative effect:
Case one, patient Wang, female, 36 years old, people from Qingdao City.First visit on January 18 in 2013.Here diagnostic symptom is as follows: menstrual period lower abdominal distention pain or spasmic pain, susceptible to lose temper due to restlessness, breast side of body distending pain of the breast, menorrhagia, has block, and uterus increases, and body of the tongue is purple.This symptom is qi depression to blood stasis.Analyze reason due to after raw second child carries out cesarotomy the year before, depressed emotion, hepatitis catharsis, functional activity of QI being not smooth, blood fortune is obstructed, qi depression to blood stasis, blood stasis amasss in born of the same parents, with the passing of time Cheng mass in the abdomen, so uterus increases adopt made preparation in the embodiment of the present invention one, and selected preparation method, after a course for the treatment of of treatment, effect is very good, thoroughly cures after two courses for the treatment of, clinical symptoms disappears completely, and Effect of follow-up visit by telephone does not recur for 1 year.
Case two, patient Lee, female, 29 years old, people from Weifang, Shandong.Come here on May 14th, 2013 to go to a doctor, symptom is as follows after diagnosing: lower abdominal colic during menstruation or cold type of pain, tenderness, pain alleviated while getting warmth, menorrhagia, and color is purple dark, and have block, aversion to cold and cold limbs, dark tongue quality has petechia, deep and tense pulse.This symptom is cold blood stasis type.Because after Therapeutic Abortion, blood room is just opened, cold-evil takes advantage of a weak point in opponent's defence and invades in born of the same parents, and fight with blood and tie, cold coagulation is blood stasis then, and retention of blood stasis is in born of the same parents, and with the passing of time Cheng mass in the abdomen, so uterus increase.Adopt made preparation in the embodiment of the present invention one, and selected preparation method, after a course for the treatment of of treatment, effect is very good, and thoroughly cure after two courses for the treatment of, clinical symptoms disappears completely, and Effect of follow-up visit by telephone does not recur half a year.
Case three: Song, female, 38 years old, family's Yishui, Shandong, JIUYUE in 2013 first visit on the 22nd.After diagnosing: menstrual period lower abdomen pain with tenderness, menorrhagia, matter is rare as water, has clot, and uterus increases, chest distress, profuse leukorrhea, and color is white, and matter is thick, deep-rolling pulse and string.This symptom is expectorant blood stasis type.Analyze reason: due to stagnation of QI due to depression of the liver or insufficiency of the spleen insufficiency of kidney-YANG, water-damp not being transformed, gather and wet into expectorant, phlegm-damp is tied in born of the same parents, ties mutually with vim and vigour, with the passing of time Cheng mass in the abdomen.Adopt made preparation in the embodiment of the present invention one, and selected preparation method, after a course for the treatment of of treatment, effect is very good, and clinical symptoms disappears completely, and Effect of follow-up visit by telephone does not recur half a year.
Claims (4)
1. the Chinese medicine preparation for adenomyosis, it is characterized in that, this Chinese medicine preparation is made up of the medicine of following weight portion: the Radix Astragali 28 ~ 32g, Radix Paeoniae Rubra 13 ~ 17g, Pheretima 18 ~ 22g, Rhizoma Chuanxiong 8 ~ 12g, Fructus Foeniculi 13 ~ 17g, Rhizoma Zingiberis 13 ~ 17g, Radix Angelicae Sinensis 18 ~ 22g, Semen Persicae 13 ~ 17g, Flos Carthami 13 ~ 17g, Fructus Aurantii 13 ~ 17g, Rhizoma Corydalis 13 ~ 17g, Oletum Trogopterori 13 ~ 17g, Cortex Moutan 8 ~ 12g, the Radix Linderae 13 ~ 17g, Rhizoma Cyperi 13 ~ 17g, Fructus Toosendan 13 ~ 17g, Pollen Typhae 13 ~ 17g, Scorpio 4 ~ 8g, Rhizoma Sparganii 13 ~ 17g, Rhizoma Curcumae 13 ~ 17g, Sanguis Draxonis 13 ~ 17g, Squama Manis 13 ~ 17g, Spina Gleditsiae 18 ~ 22g.
2. a kind of Chinese medicine preparation for adenomyosis according to claim 1, it is characterized in that, be made up of the medicine of following weight portion: Radix Astragali 30g, Radix Paeoniae Rubra 15g, Pheretima 20g, Rhizoma Chuanxiong 10g, Fructus Foeniculi 15g, Rhizoma Zingiberis 15g, Radix Angelicae Sinensis 20g, Semen Persicae 15g, Flos Carthami 15g, Fructus Aurantii 15g, Rhizoma Corydalis 15g, Oletum Trogopterori 15g, Cortex Moutan 10g, Radix Linderae 15g, Rhizoma Cyperi 15g, Fructus Toosendan 15g, Pollen Typhae 15g, Scorpio 6g, Rhizoma Sparganii 15g, Rhizoma Curcumae 15g, Sanguis Draxonis 15g, Squama Manis 15g, Spina Gleditsiae 20g.
3. a kind of Chinese medicine preparation for adenomyosis according to claim 1 and 2, is characterized in that: described Chinese medicine preparation is decoction.
4. for a preparation method for the Chinese medicine preparation of adenomyosis, it is characterized in that, preparation method is as follows: step one: by weight of the present invention, and get clean Squama Manis and scald to heaving according to boiling hot method stir-baking in sand, cleaning, drying, smash to pieces, for subsequent use, get clean Oletum Trogopterori and put into the micro-stir-fry of pot, spray rice wrong, fry to surperficial glossy time take out, dry, for subsequent use, get Pollen Typhae and cross 100 mesh sieves, with gauze wrapping, for subsequent use: to get clean Sanguis Draxonis powder breakdown mill and cross 100 mesh sieves, for subsequent use, get clean Flos Carthami gauze to wrap up, for subsequent use, step 2: by weight proportion of the present invention, gets the Radix Astragali, Radix Paeoniae Rubra, Rhizoma Chuanxiong, Radix Angelicae Sinensis, Fructus Aurantii, Rhizoma Corydalis, Cortex Moutan, the Radix Linderae, Rhizoma Cyperi, Fructus Toosendan, Rhizoma Sparganii, Rhizoma Curcumae, Spina Gleditsiae removing impurity, cleans, run through, section, dry, for subsequent use, get Pheretima, Fructus Foeniculi, Rhizoma Zingiberis, Semen Persicae, Scorpio removing impurity, clean, cut 0.5-1cm section, dry, for subsequent use, step 3: by weight proportion of the present invention, by step one and the step 2 Chinese crude drug Radix Astragali, Radix Paeoniae Rubra, Pheretima, Rhizoma Chuanxiong, Fructus Foeniculi, Rhizoma Zingiberis, Radix Angelicae Sinensis, the Radix Linderae, Rhizoma Cyperi, Scorpio, Rhizoma Sparganii, Rhizoma Curcumae, Squama Manis, Spina Gleditsiae medical material is placed in marmite, add the water of 8 times of volumes, intense fire infusion 10 ~ 15 minutes, fiery infusion of larding speech with literary allusions is filtered for 20 ~ 30 minutes, add the water of 3 times of volumes again, by Fructus Aurantii, Rhizoma Corydalis, Oletum Trogopterori, Cortex Moutan, Fructus Toosendan drops in marmite, slow fire infusion 10 ~ 15 minutes, finally by Semen Persicae, Flos Carthami, Pollen Typhae, Sanguis Draxonis drops into marmite slow fire infusion 10 ~ 15 minutes, infusion merges gained filtrate three times repeatedly, for subsequent use, step 4: by step 3 gained filtrate sealing preserve, both Chinese medicine decoction of the present invention.
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| CN104906508A (en) * | 2015-06-12 | 2015-09-16 | 张晓风 | Traditional Chinese medicine preparation for treating scapulohumeral periarthritis and preparation method of traditional Chinese medicine preparation |
| CN104958701A (en) * | 2015-07-15 | 2015-10-07 | 张晓风 | Traditional Chinese medicine preparation for HPRL (Hyperprolactinemia) and preparation method of traditional Chinese medicine preparation |
| CN105853933A (en) * | 2016-06-07 | 2016-08-17 | 梁云爱 | Traditional Chinese medicine preparation for treating postoperative recurrence and metastasis of breast cancer and preparing method |
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| CN104906508A (en) * | 2015-06-12 | 2015-09-16 | 张晓风 | Traditional Chinese medicine preparation for treating scapulohumeral periarthritis and preparation method of traditional Chinese medicine preparation |
| CN104958701A (en) * | 2015-07-15 | 2015-10-07 | 张晓风 | Traditional Chinese medicine preparation for HPRL (Hyperprolactinemia) and preparation method of traditional Chinese medicine preparation |
| CN105853933A (en) * | 2016-06-07 | 2016-08-17 | 梁云爱 | Traditional Chinese medicine preparation for treating postoperative recurrence and metastasis of breast cancer and preparing method |
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