CN107441273A - A kind of medicinal liquor for rheumatism and preparation method thereof - Google Patents

A kind of medicinal liquor for rheumatism and preparation method thereof Download PDF

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Publication number
CN107441273A
CN107441273A CN201710941414.8A CN201710941414A CN107441273A CN 107441273 A CN107441273 A CN 107441273A CN 201710941414 A CN201710941414 A CN 201710941414A CN 107441273 A CN107441273 A CN 107441273A
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parts
folium callicarpae
rheumatism
callicarpae pedunculatae
weight
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李洋
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Nanjing Zhengkuan Pharmaceutical Technology Co Ltd
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Nanjing Zhengkuan Pharmaceutical Technology Co Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/85Verbenaceae (Verbena family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/11Pteridophyta or Filicophyta (ferns)
    • A61K36/12Filicopsida or Pteridopsida
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/25Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258Panax (ginseng)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484Glycyrrhiza (licorice)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/60Moraceae (Mulberry family), e.g. breadfruit or fig
    • A61K36/605Morus (mulberry)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/81Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A61K36/815Lycium (desert-thorn)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/888Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10Preparation or pretreatment of starting material
    • A61K2236/19Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
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Abstract

The present invention provides a kind of medicinal liquor for rheumatism, and it is prepared by the raw material of following parts by weight:20 30 parts of folium callicarpae pedunculatae, 15 25 parts of rhizoma cibotii, 10 18 parts of pyrola, 10 25 parts of ramulus mori, 8 12 parts of the root bark of Chinese wolf-berry, 8 12 parts of pseudo-ginseng, 10 20 parts of grass-leaved sweetflag, 4 10 parts of radix glycyrrhizae, and employ corresponding preparation method, the present invention have treatment rheumatic arthritis and it is promoting blood circulation and removing blood stasis the effect of.

Description

A kind of medicinal liquor for rheumatism and preparation method thereof
Technical field
The invention belongs to pharmaceutical technology field, and in particular to a kind of medicinal liquor for rheumatism and preparation method thereof.
Background technology
Wine, the title of " length of hundred medicines " is known as, by the Chinese medicine of physical fitness and wine " molten " in the medicinal liquor of one, not only preparation side Just, the property of medicine is stable, safely and effectively, and because alcohol is a kind of good semi-polarity organic solvent, Chinese medicine it is various effectively into Divide and be all soluble in wherein, wine assisting drug, wine help medicine gesture and gives full play to its effect, improve curative effect.Lack at present really effective The medicinal liquor of rheumatic arthritis is treated, and folium callicarpae pedunculatae prepares product astringent taste, has a strong impact on the use of product.
The content of the invention
Goal of the invention:In order to solve the above problems, the present invention improves a kind of medicinal liquor for rheumatism and preparation method thereof.
The content of the invention:A kind of medicinal liquor for rheumatism, it is prepared by the raw material of following parts by weight:Folium callicarpae pedunculatae 20-30 parts, dog It is ridge 15-25 parts, pyrola 10-18 parts, ramulus mori 10-25 parts, root bark of Chinese wolf-berry 8-12 parts, pseudo-ginseng 8-12 parts, grass-leaved sweetflag 10-20 parts, sweet Careless 4-10 parts.
The medicinal liquor for rheumatism, it is prepared by the raw material of following parts by weight:25 parts of folium callicarpae pedunculatae, 18 parts of rhizoma cibotii, deer rank 14 parts of grass, 15 parts of ramulus mori, 10 parts of the root bark of Chinese wolf-berry, 10 parts of pseudo-ginseng, 15 parts of grass-leaved sweetflag, 7 parts of radix glycyrrhizae.
The medicinal liquor for rheumatism, preparation method comprise the following steps:Take folium callicarpae pedunculatae to add the water of 5 times of weight, decoct 2 hours, When temperature is reduced to 30 DEG C, the cellulase of 1/4 times of folium callicarpae pedunculatae weight is added, it is 30 DEG C to control temperature, digests 2 hours, obtains Folium callicarpae pedunculatae enzymolysis liquid, the folium callicarpae pedunculatae enzymolysis liquid is added in extraction kettle, and the volume for adding 4 times of weight of folium callicarpae pedunculatae enzymolysis liquid is dense The ethanol for 75% is spent, to control temperature be 40 DEG C, extraction time is 4~5 hours, filters to obtain Japanses beauty-berry leaf extract, concentrates straight nothing Alcohol taste, spray drying, obtain folium callicarpae pedunculatae extraction powder;Rhizoma cibotii, pyrola, ramulus mori, the root bark of Chinese wolf-berry, pseudo-ginseng, grass-leaved sweetflag, radix glycyrrhizae crushed 20 mesh sieves, merge with folium callicarpae pedunculatae extraction powder, add the 35-55% soaking in Chinese liquor of 10 times of medicinal powder weight 72 hours, produce Medicinal liquor for rheumatism.
The medicinal liquor for rheumatism is preparing the application in treating rheumatoid arthritis agents.
Application of the medicinal liquor for rheumatism in activating blood and removing stasis drug is prepared.
Folium callicarpae pedunculatae, Chinese medicine name.For Verbenaceae callicarpa pedunculata Callicarpa formosana Rolfe. drying Leaf.Summer, two season of autumn branches and leaves it is luxuriant when pluck, dry.With cool blood astringing to arrest bleeding, the effect of dissipating stasis of blood removing toxicity for detumescence.It is usually used in being defeated in battle Blood, spit blood, spit blood, have blood in stool, uterine bleeding, traumatism and bleeding, pathopyretic ulcer, scald.
Beneficial effect:Folium callicarpae pedunculatae of the present invention, rhizoma cibotii, pyrola blood astringing to arrest bleeding, dissipate stasis of blood removing toxicity for detumescence, wind-damp dispelling is monarch Medicine, ramulus mori, the root bark of Chinese wolf-berry, pseudo-ginseng, grass-leaved sweetflag be promoting blood circulation and removing blood stasis, it is clearing heat and detoxicating be ministerial drug, radix glycyrrhizae is adjuvant, can treat rheumatism entirely Property arthritis.Because the cell membrane of plant is made up of cellulose, hemicellulose, pectic substance, the active ingredient of plant is often It is wrapped in cell membrane.These celluloses, hemicellulose, pectic substance are in suitable enzyme such as cellulase, hemicellulase, fruit Under the effect such as glue enzyme, mass degradation can occur, at this moment the structure of cell membrane can be destroyed, cell membrane and the production of cytoplasm structure The mass transfer barriers such as change, cell membrane, cytoplasm such as raw local loose, expansion, collapse are situated between to active ingredient from intracellular to extraction The resistance to mass tranfer of matter diffusion can be reduced, so that effective component extraction rate improves.In addition, it is in plant to contain fat-soluble, indissoluble more In water or composition not soluble in water, by adding suitable enzyme such as glucuroide or transglycosylase, it can make fat-soluble or be insoluble in Water or active ingredient not soluble in water are transferred in water-soluble glycosides sugar, so that effective component extraction rate improves.It is prepared by folium callicarpae pedunculatae Product have serious astringent taste, improve by this method extraction it is obvious,
Embodiment
Form is described in further detail again to the above of the present invention by the following examples, but should not manage this The scope solved as the above-mentioned theme of the present invention is only limitted to following embodiment, and all technologies for being realized based on the above of the present invention are equal Belong to the scope of the present invention.
Embodiment 1:Take 20 parts of folium callicarpae pedunculatae, 25 parts of rhizoma cibotii, 10 parts of pyrola, 25 parts of ramulus mori, 8 parts of the root bark of Chinese wolf-berry, 12 parts of pseudo-ginseng, 10 parts of grass-leaved sweetflag, 10 parts of radix glycyrrhizae, preparation method comprises the following steps:Take folium callicarpae pedunculatae to add the water of 5 times of weight, decoct 2 hours, treat When temperature is reduced to 30 DEG C, the cellulase of 1/4 times of folium callicarpae pedunculatae weight is added, it is 30 DEG C to control temperature, digests 2 hours, obtains purple Pearl leaf enzymolysis liquid, the folium callicarpae pedunculatae enzymolysis liquid is added in extraction kettle, and add the volumetric concentration of 4 times of weight of folium callicarpae pedunculatae enzymolysis liquid For 75% ethanol, to control temperature be 40 DEG C, extraction time is 4 hours, filters to obtain Japanses beauty-berry leaf extract, concentration directly without alcohol taste, Spray drying, obtain folium callicarpae pedunculatae extraction powder;Rhizoma cibotii, pyrola, ramulus mori, the root bark of Chinese wolf-berry, pseudo-ginseng, grass-leaved sweetflag, radix glycyrrhizae crushed 20 mesh Sieve, merge with folium callicarpae pedunculatae extraction powder, add 55% soaking in Chinese liquor of 10 times of medicinal powder weight 72 hours, produce medicine for rheumatism Wine.
Embodiment 2:Take 30 parts of folium callicarpae pedunculatae, 15 parts of rhizoma cibotii, 18 parts of pyrola, 10 parts of ramulus mori, 12 parts of the root bark of Chinese wolf-berry, 8 parts of pseudo-ginseng, 20 parts of grass-leaved sweetflag, 4 parts of radix glycyrrhizae, preparation method comprises the following steps:Take folium callicarpae pedunculatae to add the water of 5 times of weight, decoct 2 hours, treat When temperature is reduced to 30 DEG C, the cellulase of 1/4 times of folium callicarpae pedunculatae weight is added, it is 30 DEG C to control temperature, digests 2 hours, obtains purple Pearl leaf enzymolysis liquid, the folium callicarpae pedunculatae enzymolysis liquid is added in extraction kettle, and add the volumetric concentration of 4 times of weight of folium callicarpae pedunculatae enzymolysis liquid For 75% ethanol, to control temperature be 40 DEG C, extraction time is 5 hours, filters to obtain Japanses beauty-berry leaf extract, concentration directly without alcohol taste, Spray drying, obtain folium callicarpae pedunculatae extraction powder;Rhizoma cibotii, pyrola, ramulus mori, the root bark of Chinese wolf-berry, pseudo-ginseng, grass-leaved sweetflag, radix glycyrrhizae crushed 20 mesh Sieve, merge with folium callicarpae pedunculatae extraction powder, add 35% soaking in Chinese liquor of 10 times of medicinal powder weight 72 hours, produce medicine for rheumatism Wine.
Embodiment 3:Take 25 parts of folium callicarpae pedunculatae, 18 parts of rhizoma cibotii, 14 parts of pyrola, 15 parts of ramulus mori, 10 parts of the root bark of Chinese wolf-berry, pseudo-ginseng 10 Part, 15 parts of grass-leaved sweetflag, 7 parts of radix glycyrrhizae, preparation method comprises the following steps:Take folium callicarpae pedunculatae to add the water of 5 times of weight, decoct 2 hours, When temperature is reduced to 30 DEG C, the cellulase of 1/4 times of folium callicarpae pedunculatae weight is added, it is 30 DEG C to control temperature, digests 2 hours, obtains Folium callicarpae pedunculatae enzymolysis liquid, the folium callicarpae pedunculatae enzymolysis liquid is added in extraction kettle, and the volume for adding 4 times of weight of folium callicarpae pedunculatae enzymolysis liquid is dense The ethanol for 75% is spent, to control temperature be 40 DEG C, extraction time is 5 hours, filters to obtain Japanses beauty-berry leaf extract, is concentrated directly without alcohol Taste, spray drying, obtain folium callicarpae pedunculatae extraction powder;Rhizoma cibotii, pyrola, ramulus mori, the root bark of Chinese wolf-berry, pseudo-ginseng, grass-leaved sweetflag, radix glycyrrhizae crushed 20 Mesh sieve, merge with folium callicarpae pedunculatae extraction powder, add 45% soaking in Chinese liquor of 10 times of medicinal powder weight 72 hours, produce medicine for rheumatism Wine.
Comparative example 1:Take 25 parts of folium callicarpae pedunculatae, 18 parts of rhizoma cibotii, 14 parts of pyrola, 15 parts of ramulus mori, 10 parts of the root bark of Chinese wolf-berry, pseudo-ginseng 10 parts, 15 parts of grass-leaved sweetflag, 7 parts of radix glycyrrhizae, crushed 20 mesh sieves, 45% soaking in Chinese liquor 72 for adding 10 times of medicinal powder weight is small When, produce medicinal liquor for rheumatism.
Embodiment 4:Influence of the different preparation methods to medicinal liquor mouthfeel
Embodiment 1-3, and the medicinal liquor of comparative example 1 are tasted respectively, it is found that the medicinal liquor astringent taste of comparative example 1 is serious, Can not entrance, and embodiment 1-3 mouthfeels alcohol is just.
Embodiment 5:The clinical and experimental study of present invention treatment rheumatic arthritis
The preparation of sample:Medicinal liquor is prepared by the method for embodiment 1.
Clinical case:100 patients, wherein rheumatic sufferers 65, rheumatoid patient 35, while dashed forward with lumber ertebral disc What is gone out has 29, has 38 with hyperosteogeny.
Diagnostic criteria:Arthralgia, swelling, severe patient's arthrocleisis, deformity and dysfunction, laboratory examination, erythrocyte sedimentation rate, Rheumatoid factor, x-ray inspection etc. can be made a definite diagnosis.
Instructions of taking:The medicinal liquor of the present invention is taken, early, middle and late three times per bu, each 30ml, one month is a course for the treatment of.
Efficacy assessment standard:Cure:Arthralgia, swelling disappear, and recover activities.Take a turn for the better:Arthralgia, swelling subtract Gently, joint movement function improves.It is not cured:Symptom and sign is without improvement.
Therapeutic effect:One month course for the treatment of, one course for the treatment of of the lighter, two to three courses for the treatment of of severe one can take a turn for the better or cure. In 100 patients, 58 are cured, is taken a turn for the better 31, cure rate 58%, improvement rate 31%, effective percentage 89%.
The influence (function of promoting blood circulation to disperse blood clots research) of embodiment 6, the present invention to Mice Auricle microcirculation experiment
Experiment equipment:WT-6 type microcirculation instrument, the production of Xuzhou optical instrument head factory.
Medicine:ZHENGHONGHUA YOU, manufacturing enterprise:Liang Jiefu medicines private limited partnership of Singapore;Authentication code:Chinese medicines quasi-word Z20093693, lot number:20120722;Rheumatic oil is prepared by above-described embodiment 1-3.
Animal:ICR mouse 18-22g, female, our company's Experimental Animal Center provide.
Experimental method:18~22gICR of body weight mouse 50 are taken, female, are randomly divided into 4 groups, (1) blank control group (physiology Salt solution), (2) ZHENGHONGHUA YOU group (0.16ml/20g), 1 group of medicinal liquor of (3) embodiment of the present invention, 2 groups of medicines of (4) embodiment of the present invention Wine, 3 groups of medicinal liquor of (5) embodiment of the present invention, it is double that blank control group, ZHENGHONGHUA YOU group and embodiment 1-3 groups animal apply mouse outside Pick up the ears a two sides, 1 time a day, 10d to be administered altogether.It is injected intraperitoneally after 10d is administered by every yellow Jackets 0.01mL/g of mouse 1% After anesthesia, unhairing on auricle is attached to Medical adhesive plaster, mouse abdomen is downwardly fixed on mouse observation platform, auricle surface is added dropwise A little atoleine.Observe administration group and the same position auricular microcirculation diameter of capillary of blank group, velocity of blood flow.
Paraxylene of the present invention causes the influence (n=10 of Mice Auricle microcirculation;X ± SD, %)
Note:Compared with blank group:*P<0.05
The above results show:1-3 of embodiment of the present invention groups can be such that output branch, input tap footpath substantially expands (with blank group Compare P<0.05), and velocity of blood flow is substantially speeded, have conspicuousness effect, and effect is better than ZHENGHONGHUA YOU positive drug group.

Claims (5)

1. a kind of medicinal liquor for rheumatism, it is characterised in that it is prepared by the raw material of following parts by weight:Folium callicarpae pedunculatae 20-30 parts, dog It is ridge 15-25 parts, pyrola 10-18 parts, ramulus mori 10-25 parts, root bark of Chinese wolf-berry 8-12 parts, pseudo-ginseng 8-12 parts, grass-leaved sweetflag 10-20 parts, sweet Careless 4-10 parts.
2. medicinal liquor for rheumatism as claimed in claim 1, it is characterised in that it is prepared by the raw material of following parts by weight:Japanses beauty-berry 25 parts of leaf, 18 parts of rhizoma cibotii, 14 parts of pyrola, 15 parts of ramulus mori, 10 parts of the root bark of Chinese wolf-berry, 10 parts of pseudo-ginseng, 15 parts of grass-leaved sweetflag, 7 parts of radix glycyrrhizae.
3. medicinal liquor for rheumatism as claimed in claim 1, it is characterised in that preparation method comprises the following steps:Folium callicarpae pedunculatae is taken to add 5 times The water of weight, decoct 2 hours, when temperature is reduced to 30 DEG C, add the cellulase of 1/4 times of folium callicarpae pedunculatae weight, control temperature For 30 DEG C, digest 2 hours, obtain folium callicarpae pedunculatae enzymolysis liquid, the folium callicarpae pedunculatae enzymolysis liquid is added in extraction kettle, and add folium callicarpae pedunculatae enzyme The volumetric concentration for solving 4 times of weight of liquid is 75% ethanol, and to control temperature be 40 DEG C, extraction time is 4~5 hours, filters purple Pearl leaf extract, concentration directly without alcohol taste, spray drying, obtain folium callicarpae pedunculatae extraction powder;Rhizoma cibotii, pyrola, ramulus mori, the root bark of Chinese wolf-berry, three 7th, grass-leaved sweetflag, radix glycyrrhizae crushed 20 mesh sieves, merge with folium callicarpae pedunculatae extraction powder, add the 35-55% of 10 times of medicinal powder weight Soaking in Chinese liquor 72 hours, produces medicinal liquor for rheumatism.
4. medicinal liquor for rheumatism as claimed in claim 1 is preparing the application in treating rheumatoid arthritis agents.
5. application of the medicinal liquor for rheumatism as claimed in claim 1 in activating blood and removing stasis drug is prepared.
CN201710941414.8A 2017-10-11 2017-10-11 A kind of medicinal liquor for rheumatism and preparation method thereof Withdrawn CN107441273A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109350658A (en) * 2018-12-14 2019-02-19 北京蜂珍科技开发有限公司 A kind of bee venom Chinese medicine scraping oil for rheumatic arthritis

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102058673A (en) * 2010-12-15 2011-05-18 湖南九典制药有限公司 Chinese medicine composition for expelling wind and removing dampness and preparation method thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102058673A (en) * 2010-12-15 2011-05-18 湖南九典制药有限公司 Chinese medicine composition for expelling wind and removing dampness and preparation method thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109350658A (en) * 2018-12-14 2019-02-19 北京蜂珍科技开发有限公司 A kind of bee venom Chinese medicine scraping oil for rheumatic arthritis

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Application publication date: 20171208