CN103623096A - Reconstruction pill for treating hemiplegia and restoring consciousness and preparation method thereof - Google Patents
Reconstruction pill for treating hemiplegia and restoring consciousness and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a reconstruction pill for treating hemiplegia and restoring consciousness, and a preparation method thereof. The traditional Chinese medicine composition comprises fineleaf schizonepeta herb, himalayan teasel roots, common four-o'clock roots, Chinese honeylocust fruit, common jasminorange, pine nodular branches, stem of oriental bittersweet and radix glycyrrhizae. The traditional Chinese medicine composition can be prepared into any clinically-acceptable oral pharmaceutical preparation according to the conventional traditional Chinese medicine preparation method. The traditional Chinese medicine composition made of the traditional Chinese medicines has the efficacy of dredging collaterals and recovering hemiplegia, dispelling wind and resolving phlegm, tonifying kidney and reinforcing tendon, reinforcing qi and nourishing blood, and resolving hard lump. Clinical curative effect observation verifies that the traditional Chinese medicine composition disclosed by the invention can be used for comprehensively treating apoplexy hemiplegia symptoms such as hemiplegia, facial paralysis, numbness of limbs and the like, which are caused by apoplexy, and the curative effect is accurate, reliable and real. The traditional Chinese medicine composition is non-poisonous and harmless, safe and reliable, has no any side effect after being taken, and is safe in clinical use.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, relate in particular to a kind of Chinese medicine composition for the treatment of apoplexy sequela and preparation method thereof, belong to the treatment by Chinese herbs field of apoplexy.
Background technology
Apoplexy is also apoplexy.Be divided into two types: in ischemic cerebral apoplexy and hemorrhagic apoplexy.Apoplexy is the general designation of Chinese medicine to acute cerebrovascular disease.It is suddenly to faint, syncope, the distortion of commissure that occurs together, dysphonia and occur that hemiplegia is a class disease of cardinal symptom.Because primary disease sickness rate is high, mortality rate is high, disability rate is high, relapse rate is high and complication is many, so medical circle is listed as its same coronary heart disease, cancer one of three large diseases that threaten human health.
Hemiplegia is again hemiplegia, refers to the dyskinesia of a side upper and lower extremities, facial muscle and lingualis bottom, is a common sympton of acute cerebrovascular disease, and hemiplegic patient can't take care of oneself mostly, has had a strong impact on patient's life quality.
At present, the Chinese patent medicine that is used for the treatment of apoplectic hemiplegia all in various degree exist slow, the defect such as curative effect is remarkable not that takes effect, have much room for improvement.
Summary of the invention
Technical problem to be solved by this invention is to overcome existing slow, the defect such as curative effect is remarkable not that takes effect of the Chinese medicine composition of existing treatment apoplectic hemiplegia, the Chinese medicine composition of the treatment apoplectic hemiplegia that provide a kind of instant effect, determined curative effect, has no side effect;
Another technical problem to be solved by this invention is to provide a kind of method of preparing above-mentioned Chinese medicine composition.
Above-mentioned technical problem to be solved by this invention is achieved through the following technical solutions:
Treat a Chinese medicine composition for apoplectic hemiplegia, comprise following component: Herba Schizonepetae, Radix Dipsaci, Radix Mirabilis, Fructus Gleditsia, Folium Et Cacumen Murrayae, Lignum Pini Nodi, Celastrus orbiculatus Thunb. and Radix Glycyrrhizae.
Preferably, the weight portion of each component is: Herba Schizonepetae 12-28 part, Radix Dipsaci 10-25 part, Radix Mirabilis 10-25 part, Fructus Gleditsia 5-15 part, Folium Et Cacumen Murrayae 2-10 part, Lignum Pini Nodi 2-8 part, Celastrus orbiculatus Thunb. 2-8 part, Radix Glycyrrhizae 1-6 part.
Most preferred, the weight portion of each component is: 20 parts of Herba Schizonepetae, 18 parts of Radix Dipsacis, 16 parts of Radix Mirabiliss, 12 parts, Fructus Gleditsia, 8 parts of Folium Et Cacumen Murrayae, 6 parts of Lignum Pini Nodis, 6 parts of Celastrus orbiculatus Thunb.s, 2 parts, Radix Glycyrrhizae.
Herba Schizonepetae: the dry aerial parts of labiate Herba Schizonepetae Schizonepeta tenuifolia Briq..Property is pungent, tepor.Return lung, Liver Channel.Function cures mainly: the loose wind that induces sweat, rash.For flu, headache, measles, rubella, skin infection from the beginning of.Parch to black treating hematochezia, metrorrhagia, puerperal blood faints.
Radix Dipsaci: be the dry root of Dipsacaceae plant Radix Dipsaci Dipsacus asperoides C.Y.Cheng et T.M.Ai..Bitter in the mouth; Pungent; Slightly warm in nature.Return liver; Kidney channel.Invigorating the liver and kidney; Bone and muscle strengthening; Blood circulation regulating; Continuous injured; Only metrorrhagia.For aching pain in waist and back; Podomere flaccidity syndrome and arthralgia syndrome; Fall flutter wound, damage muscle folding bone, red, metrorrhagia is leaked in fetal movement, seminal emission, leukorrhagia, carbuncle skin ulcer are swollen.Prepared RADIX DIPSACI with yellow rice wine is used for rheumatic arthralgia, injury from falling down.Prepared RADIX DIPSACI with salt solution is used for soreness of the waist and knees.
Fructus Gleditsia (Fructus Gleditsia) (Gleditsia sinensis Lam): return through lung; Large intestine channel.Effect: expelling phlegm for arresting cough; Have one's ideas straightened out to lead to and close; Parasite killing eliminating stagnation.Cure mainly: productive cough dyspnea with fullness of the chest; Apoplexy locked mouth; Accumulation and obstruction of sputum; Coma in silence; Epilepsy; Sore throat; Constipation and anuresis; Carbuncle scabies.
Radix Mirabilis: be the tuber of Nyctaginaceae plant Mirabilis jalapa.Nature and flavor: sweetness and bitterness, flat.Function cures mainly: diuresis, purge heat, and promoting blood circulation to remove blood stasis.Control stranguria with turbid discharge, leukorrhagia, impairment of the lung caused by overstrain is spitted blood, carbuncle carbuncle on the back, acute arthritis.
Folium Et Cacumen Murrayae: different name Radix Buddlejae Butterflybush, Murraya paniculata (L.) Jack., five li of perfume (or spice), Clausena excavata Burm.f., water Rohdea japonica Roth, tetramerous jasminorange leaf, month Fructus Citri tangerinae.Stem and leaf for rutaceae Folium Et Cacumen Murrayae.Nature and flavor: acrid in the mouth, micro-hardship, warm in nature.GUIXIN, liver, lung meridian.Function cures mainly: circulation of qi promoting, invigorate blood circulation, and dispel the wind, dehumidifying, and have analgesia effect.Main gastral cavity abdomen pain due to disorder of QI, tumbling and swelling, Jie skin ulcer, skin pruritus.
Lignum Pini Nodi: another name yellow pine knaur, Pine Nodular Branch, loose youth's head; Medical material Ji Yuan is the tuberosity of the branchs such as pinaceae plant Pinus tabuliformis, Pinus massoniana Lamb, Pinus densiflora, pinus yunnanensis faranch.Property bitter, temperature, returns Liver Channel.Effect is dispeiling pathogenic wind and removing dampness, pain relieving.For main anemofrigid-damp arthralgia, severe and migratory arthralgia pain; Foot numbness flaccidity is soft; Traumatic pain.
Celastrus orbiculatus Thunb.: different name is crossed mountain phoenix, hung wide whip, XIANGLONGCAO, Cortex Ampelopsis Aconitifoliae Radicis, Lobaria pulmonaria (L.) Hoffm., Rhizoma Dioscoreae Nipponicae, old tendon Bovis seu Bubali etc.Rattan for Celastraceae plant Celastrus orbiculatus Thunb..Nature and flavor: micro-pungent, temperature, nontoxic (< < commonly uses Chinese herbal medicine formula > >).Function cures mainly: wind-damp dispelling, the network of invigorating blood circulation.Control bones and muscles pain, numb limbs and tense tendons, infantile convulsion, acute filthy disease, dysentery.
Chinese medicine composition of the present invention is to the pathogenetic research of the deep layer of apoplexy and Therapeutic Principle thereof based on inventor, simultaneously according to inventor clinical experience and pharmaceutical research achievement for many years, the crude drug that filters out Tongluo Futan, dispelling pathogenic wind and eliminating phlegm, the strong muscle of the kidney invigorating, benefiting QI and nourishing blood, forms according to certain weight proportion prescription.
The effect while adding in the present invention the crude drug of following weight portion in drug composition with better blood circulation promoting and blood stasis dispelling, dispelling pathogenic wind and eliminating phlegm: Lignum Sappan 3-9 part, Herba Syneilesis Aconitifoliae 2-7 part; Preferably, the weight portion of each raw material is: 8 parts of Lignum Sappans, 6 parts of Herba Syneilesis Aconitifoliae.
Lignum Sappan: be the dry duramen of pulse family (Fabaceae) Semen Caesalpiniae genus (Caesalpinia) plant Lignum Sappan C.sappan.There is promoting the circulation of blood dredging collateral, stasis-dispelling and pain-killing, the effect of loose wind and blood.
Herba Syneilesis Aconitifoliae: be root or the herb of feverfew Herba Syneilesis Aconitifoliae, have that removing toxic substances is invigorated blood circulation, dispelled wind and removed dampness, the effect of reducing swelling and alleviating pain.
In side of the present invention, each medicine compatibility is played the effect of Tongluo Futan, dispelling pathogenic wind and eliminating phlegm, the strong muscle of the kidney invigorating, benefiting QI and nourishing blood, hard masses softening and resolving together altogether, is treatment neuropathy, apoplexy, hemiplegia acute stage, the efficient good medicine of convalescent period and sequela.Through long term clinical results, observe the experimentation of the aspects such as pharmacology and biochemistry.Clinical proof this product has blood vessel dilating, improves microcirculation, increases blood flow, regulates function of nervous system, increases neurotrophy, promotes nerve metabolism, repairs the effects such as neurocyte function.Function with cure mainly: blood circulation promoting and blood stasis dispelling, clearing away heat and nourishing YIN, vigorate qi and replenish the blood, strengthening the spleen to promote digestion, with with thromboangiitis obliterans, venous thrombosis, arteriosclerosis, cerebral thrombosis and hemorrhagic and ischemic sequela (hemiplegia, hemiplegia, deviation of the mouth with numbness and paralysis, slobbering, slurred speech, stupor, swollen foot and knee, walks difficult, carpopedal spasm, coronary heart disease, amyotrophy, facial spasm, brain injury sequela, neuropathy, radiation disease is unable etc.).
Chinese medicine composition of the present invention is nontoxic, safe and reliable, after taking, has no adverse reaction, clinical use safety.
The present invention's each taste crude drug used can be bought and obtain at pharmacy.
Medicine activity component of the present invention can add various adjuvants required while preparing different dosage form, such as disintegrating agent, lubricant, adhesive etc., with conventional method of Chinese medicinal, be prepared into any suitable clinical oral administration preparation, described oral formulations can be pill, powder, granule, capsule, tablet, oral liquid, drop pill etc.
A kind of preparation method of Chinese medicine composition of the present invention: after each crude drug of the present invention is taken by described weight portion proportioning, pulverize, sieve (can be for example 80-300 mesh sieve), obtains.Certainly, after also each crude drug can being pulverized, add the required adjuvant of preparations shaping or excipient, according to conventional method, be prepared into capsule, tablet or pill.
The another kind of preparation method of Chinese medicine composition of the present invention: take each crude drug by described weight portion; Each crude drug water is decocted, merge decoction liquor, filter, filtrate is condensed into clear paste, adds adjuvant or the excipient of preparations shaping, and preparations shaping, obtains.
The usage of Chinese medicine composition of the present invention and consumption: dosage of the present invention depends on the factors such as concrete dosage form, patient's age, health status.As guidance: usage and dosage: capsule, each capsule is containing 0.3 gram of crude drug, and each oral 3 to 4,3 times on the one 15 days is a course for the treatment of.
The specific embodiment
Below in conjunction with specific embodiment, further describe the present invention; these embodiment are only exemplary; what those skilled in the art should understand that is; lower without departing from the spirit and scope of the present invention, can the details of technical solution of the present invention and form modified or be replaced, but these modifications and replacement all fall within the scope of protection of the present invention.
The preparation of embodiment 1 capsule
By following weight, take each crude drug (unit: g): Herba Schizonepetae 12, Radix Dipsaci 10, Radix Mirabilis 10, Fructus Gleditsia 5, Folium Et Cacumen Murrayae 2, Lignum Pini Nodi 2, Celastrus orbiculatus Thunb. 2, Radix Glycyrrhizae 1;
Above-mentioned each crude drug is decocted with water to secondary, add for the first time 4 times of weight of water, decoct 2 hours, add for the second time 5 times of weight of water, decoct 1.5 hours; Decoction liquor is merged, filter, it is 1.17-1.19(60 ℃ that filtrate is concentrated into relative density) clear paste; Merge clear paste twice, add appropriate amount of starch, mix, be dried, pulverize, add appropriate amount of ethanol granulation, dry, granulate, filled capsules, obtains.
The preparation of embodiment 2 capsules
By following weight, take each crude drug (unit: g): Herba Schizonepetae 28, Radix Dipsaci 25, Radix Mirabilis 25, Fructus Gleditsia 15, Folium Et Cacumen Murrayae 10, Lignum Pini Nodi 8, Celastrus orbiculatus Thunb. 8, Radix Glycyrrhizae 6;
Above-mentioned each crude drug is decocted with water to secondary, add for the first time 6 times of weight of water, decoct 2 hours, add for the second time 4 times of weight of water, decoct 1.5 hours; Decoction liquor is merged, filter, it is 1.17-1.19(60 ℃ that filtrate is concentrated into relative density) clear paste; Merge clear paste twice, add appropriate amount of starch, mix, be dried, pulverize, add appropriate amount of ethanol granulation, dry, granulate, filled capsules, obtains.
The preparation of embodiment 3 capsules
By following weight, take each crude drug (unit: g): Herba Schizonepetae 20, Radix Dipsaci 18, Radix Mirabilis 16, Fructus Gleditsia 12, Folium Et Cacumen Murrayae 8, Lignum Pini Nodi 6, Celastrus orbiculatus Thunb. 6, Radix Glycyrrhizae 2;
Above-mentioned each crude drug is decocted with water to secondary, add for the first time 4 times of weight of water, decoct 2 hours, add for the second time 5 times of weight of water, decoct 1.5 hours; Decoction liquor is merged, filter, it is 1.30-1.35(55 ℃ that filtrate is concentrated into relative density) clear paste; Merge clear paste twice, add appropriate amount of starch, mix, be dried, pulverize, add appropriate amount of ethanol granulation, dry, granulate, filled capsules, obtains.
The preparation of embodiment 4 capsules
By following weight, take each crude drug (unit: g): Herba Schizonepetae 12, Radix Dipsaci 10, Radix Mirabilis 10, Fructus Gleditsia 5, Folium Et Cacumen Murrayae 2, Lignum Pini Nodi 2, Celastrus orbiculatus Thunb. 2, Radix Glycyrrhizae 1, Lignum Sappan 3, Herba Syneilesis Aconitifoliae 2;
Above-mentioned each crude drug is decocted with water to secondary, add for the first time 4 times of weight of water, decoct 2 hours, add for the second time 5 times of weight of water, decoct 1.5 hours; Decoction liquor is merged, filter, it is 1.30-1.35(55 ℃ that filtrate is concentrated into relative density) clear paste; Merge clear paste twice, add appropriate amount of starch, mix, be dried, pulverize, add appropriate amount of ethanol granulation, dry, granulate, filled capsules, obtains.
The preparation of embodiment 5 capsules
By following weight, take each crude drug (unit: g): Herba Schizonepetae 28, Radix Dipsaci 25, Radix Mirabilis 25, Fructus Gleditsia 15, Folium Et Cacumen Murrayae 10, Lignum Pini Nodi 8, Celastrus orbiculatus Thunb. 8, Radix Glycyrrhizae 6, Lignum Sappan 9, Herba Syneilesis Aconitifoliae 7;
Above-mentioned each crude drug is decocted with water to secondary, add for the first time 6 times of weight of water, decoct 2 hours, add for the second time 4 times of weight of water, decoct 1.5 hours; Decoction liquor is merged, filter, it is 1.17-1.19(60 ℃ that filtrate is concentrated into relative density) clear paste; Merge clear paste twice, add appropriate amount of starch, mix, be dried, pulverize, add appropriate amount of ethanol granulation, dry, granulate, filled capsules, obtains.
The preparation of embodiment 6 capsules
By following weight, take each crude drug (unit: g): Herba Schizonepetae 20, Radix Dipsaci 18, Radix Mirabilis 16, Fructus Gleditsia 12, Folium Et Cacumen Murrayae 8, Lignum Pini Nodi 6, Celastrus orbiculatus Thunb. 6, Radix Glycyrrhizae 2, Lignum Sappan 8, Herba Syneilesis Aconitifoliae 6;
Above-mentioned each crude drug is decocted with water to secondary, add for the first time 6 times of weight of water, decoct 2 hours, add for the second time 4 times of weight of water, decoct 1.5 hours; Decoction liquor is merged, filter, it is 1.17-1.19(60 ℃ that filtrate is concentrated into relative density) clear paste; Merge clear paste twice, add appropriate amount of starch, mix, be dried, pulverize, add appropriate amount of ethanol granulation, dry, granulate, filled capsules, obtains.
The preparation of embodiment 7 watered pills
By following weight, take each crude drug (unit: g): Herba Schizonepetae 20, Radix Dipsaci 18, Radix Mirabilis 16, Fructus Gleditsia 12, Folium Et Cacumen Murrayae 8, Lignum Pini Nodi 6, Celastrus orbiculatus Thunb. 6, Radix Glycyrrhizae 2, Lignum Sappan 8, Herba Syneilesis Aconitifoliae 6;
Above-mentioned each crude drug is decocted with water to secondary, add for the first time 6 times of weight of water, decoct 2 hours, add for the second time 4 times of weight of water, decoct 1.5 hours; Decoction liquor is merged, filter, it is 1.17-1.19(60 ℃ that filtrate is concentrated into relative density) clear paste; Merge clear paste twice, with water, make binding agent, the general watered pill of making, dry, subpackage, packing, gets product.
The preparation of embodiment 8 water-honeyed pills
By following weight, take each crude drug (unit: g): Herba Schizonepetae 20, Radix Dipsaci 18, Radix Mirabilis 16, Fructus Gleditsia 12, Folium Et Cacumen Murrayae 8, Lignum Pini Nodi 6, Celastrus orbiculatus Thunb. 6, Radix Glycyrrhizae 2, Lignum Sappan 8, Herba Syneilesis Aconitifoliae 6;
Each crude drug is mixed and is ground into fine powder, cross 100 mesh sieves, get appropriate refined honey, with refined honey, water, make binding agent, the general water-honeyed pill of making, dry, subpackage, packing, gets product.
The clinical observation on the therapeutic effect test of test example 1 traditional Chinese medicine composition for treating apoplectic hemiplegia of the present invention
One, physical data: the 136 routine patients that outpatient service is accepted for medical treatment all meet the clinical criteria of apoplectic hemiplegia, and 136 routine patients are divided into 2 groups at random, every group of 68 examples; 2 groups of no significant differences on sex, age, the course of disease and coincident with severity degree of condition.
Two, trial drug
The medicine that embodiment of the present invention 1-8 is prepared.
Three, Therapeutic Method
136 patients are divided into respectively to 2 groups at random, that is: test 1 group and test 2, every group of each 68 examples, test 1 group and adopt the prepared capsule treatment of embodiment 1-3, test 2 groups and adopt the prepared capsule treatment of embodiment 4-6; Oral, one time 4 (0.3g crude drug/grain), 3 times on the one 15 days is a course for the treatment of, treats altogether 6 courses for the treatment of.
Four, efficacy assessment standard
Effective: hemiplegia symptom disappears substantially, patient can walk, and life is taken care of oneself substantially;
Effective: hemiplegia symptom takes a turn for the better to some extent, language function normal, can lean on crutch walking;
Invalid: hemiplegia symptom is without any improvement.
Five, clinical observation result
Clinical observation result is in Table 1.
The clinical observation on the therapeutic effect result of the test of table 1 traditional Chinese medicine composition for treating apoplectic hemiplegia of the present invention
Clinical observation on the therapeutic effect result shows, Chinese medicine composition of the present invention has significant curative effect for Hemiplegic Patients; Wherein, test the therapeutic effect of 2 groups and will significantly be better than testing the therapeutic effect of 1 group; Safety observe to be found, does not observe any clinical adverse, show Chinese medicine composition clinical practice of the present invention safely, have no side effect.
Claims (10)
1. a Chinese medicine composition for the treatment of apoplectic hemiplegia, is characterized in that, comprises following component: Herba Schizonepetae, Radix Dipsaci, Radix Mirabilis, Fructus Gleditsia, Folium Et Cacumen Murrayae, Lignum Pini Nodi, Celastrus orbiculatus Thunb. and Radix Glycyrrhizae.
2. according to Chinese medicine composition claimed in claim 1, it is characterized in that, the weight portion of each component is: Herba Schizonepetae 12-28 part, Radix Dipsaci 10-25 part, Radix Mirabilis 10-25 part, Fructus Gleditsia 5-15 part, Folium Et Cacumen Murrayae 2-10 part, Lignum Pini Nodi 2-8 part, Celastrus orbiculatus Thunb. 2-8 part, Radix Glycyrrhizae 1-6 part.
3. according to Chinese medicine composition claimed in claim 2, it is characterized in that, the weight portion of each component is: 20 parts of Herba Schizonepetae, 18 parts of Radix Dipsacis, 16 parts of Radix Mirabiliss, 12 parts, Fructus Gleditsia, 8 parts of Folium Et Cacumen Murrayae, 6 parts of Lignum Pini Nodis, 6 parts of Celastrus orbiculatus Thunb.s, 2 parts, Radix Glycyrrhizae.
4. a Chinese medicine composition for the treatment of apoplectic hemiplegia, is characterized in that, comprises following component: Herba Schizonepetae, Radix Dipsaci, Radix Mirabilis, Fructus Gleditsia, Folium Et Cacumen Murrayae, Lignum Pini Nodi, Celastrus orbiculatus Thunb., Radix Glycyrrhizae, Lignum Sappan and Herba Syneilesis Aconitifoliae.
5. according to Chinese medicine composition claimed in claim 4, it is characterized in that, the weight portion of each component is: Herba Schizonepetae 12-28 part, Radix Dipsaci 10-25 part, Radix Mirabilis 10-25 part, Fructus Gleditsia 5-15 part, Folium Et Cacumen Murrayae 2-10 part, Lignum Pini Nodi 2-8 part, Celastrus orbiculatus Thunb. 2-8 part, Radix Glycyrrhizae 1-6 part, Lignum Sappan 3-9 part, Herba Syneilesis Aconitifoliae 2-7 part.
6. according to Chinese medicine composition claimed in claim 5, it is characterized in that, the weight portion of each component is: 20 parts of Herba Schizonepetae, 18 parts of Radix Dipsacis, 16 parts of Radix Mirabiliss, 12 parts, Fructus Gleditsia, 8 parts of Folium Et Cacumen Murrayae, 6 parts of Lignum Pini Nodis, 6 parts of Celastrus orbiculatus Thunb.s, 2 parts, Radix Glycyrrhizae, 8 parts of Lignum Sappans, 6 parts of Herba Syneilesis Aconitifoliae.
7. a method of preparing claim 1-6 Chinese medicine composition described in any one, comprises the following steps:
(1), by described weight proportion, take each crude drug;
(2) each crude drug water is decocted, merge decoction liquor, filter, filtrate is condensed into clear paste, adds adjuvant or the excipient of preparations shaping, and preparations shaping, obtains.
8. a method of preparing claim 1-6 Chinese medicine composition described in any one, comprises the following steps: by each component, pulverize, sieve, add the required adjuvant of preparations shaping or excipient, according to conventional method, be prepared into capsule, tablet or pill.
9. claim 1-6 Chinese medicine composition purposes in preparation treatment apoplectic hemiplegia medicine described in any one.
10. claim 1-6 Chinese medicine composition purposes in preparation treatment hemorrhagic or ischemic sequela medicine described in any one.
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