CN103623096B - Hemiplegia xingnao zaizao pill and preparation method thereof - Google Patents
Hemiplegia xingnao zaizao pill and preparation method thereof Download PDFInfo
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Abstract
The invention discloses hemiplegia xingnao zaizao pill and preparation method thereof.Described Chinese medicine composition comprises: Herba Schizonepetae, Radix Dipsaci, Radix Mirabilis, Fructus Gleditsia, Folium Et Cacumen Murrayae, Lignum Pini Nodi, Celastrus orbiculatus Thunb. and Radix Glycyrrhizae.Chinese medicine composition of the present invention can be prepared into any one acceptable oral drug preparation clinically according to Chinese medicine conventional formulation method.Chinese medicine composition compatibility of the present invention has effect of Tongluo Futan, dispelling pathogenic wind and eliminating phlegm, the strong muscle of the kidney invigorating, benefiting QI and nourishing blood, hard masses softening and resolving together; Clinical observation on the therapeutic effect confirms, Chinese medicine composition of the present invention in the apoplectic hemiplegia symptom treating both the principal and secondary aspects of a disease such as wind-induced hemiplegia, facial hemiparalysis, numb limbs and tense tendons, determined curative effect is reliable, true.Chinese medicine composition of the present invention is nontoxic, safe and reliable, takes rear without any untoward reaction, Clinical practice safety.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, particularly relate to a kind of Chinese medicine composition for the treatment of apoplexy sequela and preparation method thereof, belong to the treatment by Chinese herbs field of apoplexy.
Background technology
Apoplexy is also apoplexy.Be divided into two types: in ischemic cerebral apoplexy and hemorrhagic apoplexy.Apoplexy is the general designation of Chinese medicine to acute cerebrovascular disease.It is suddenly fainted, syncope, the distortion of commissure that occurs together, dysphonia and occur that hemiplegia is a class disease of cardinal symptom.Because primary disease sickness rate is high, mortality rate is high, disability rate is high, relapse rate is high and complication is many, so medical circle is listed as one of three large diseases threatening human health its same coronary heart disease, cancer.
Hemiplegia is hemiplegia again, and refer to the dyskinesia of side upper and lower extremities, facial muscle and lingualis bottom, be a common sympton of acute cerebrovascular disease, hemiplegic patient can't take care of oneself mostly, has had a strong impact on the life quality of patient.
At present, the Chinese patent medicine being used for the treatment of apoplectic hemiplegia also existing all is in various degree taken effect slow, the defect such as curative effect is remarkable not, haves much room for improvement.
Summary of the invention
Technical problem to be solved by this invention is slow, the defect such as curative effect is remarkable not that takes effect existing for Chinese medicine composition overcoming existing treatment apoplectic hemiplegia, the Chinese medicine composition for the treatment of apoplectic hemiplegia provide a kind of instant effect, determined curative effect, having no side effect;
Another technical problem to be solved by this invention is to provide a kind of method preparing above-mentioned Chinese medicine composition.
Above-mentioned technical problem to be solved by this invention is achieved through the following technical solutions:
Treat a Chinese medicine composition for apoplectic hemiplegia, comprise following component: Herba Schizonepetae, Radix Dipsaci, Radix Mirabilis, Fructus Gleditsia, Folium Et Cacumen Murrayae, Lignum Pini Nodi, Celastrus orbiculatus Thunb. and Radix Glycyrrhizae.
Preferably, the weight portion of each component is: Herba Schizonepetae 12-28 part, Radix Dipsaci 10-25 part, Radix Mirabilis 10-25 part, Fructus Gleditsia 5-15 part, Folium Et Cacumen Murrayae 2-10 part, Lignum Pini Nodi 2-8 part, Celastrus orbiculatus Thunb. 2-8 part, Radix Glycyrrhizae 1-6 part.
Most preferred, the weight portion of each component is: Herba Schizonepetae 20 parts, Radix Dipsaci 18 parts, Radix Mirabilis 16 parts, 12 parts, Fructus Gleditsia, Folium Et Cacumen Murrayae 8 parts, Lignum Pini Nodi 6 parts, Celastrus orbiculatus Thunb. 6 parts, 2 parts, Radix Glycyrrhizae.
Herba Schizonepetae: the dry aerial parts of labiate Herba Schizonepetae Schizonepeta tenuifolia Briq..Property is pungent, tepor.Return lung, Liver Channel.Function cures mainly: induce sweat loose wind, rash.For flu, headache, measles, rubella, skin infection from the beginning of.Parch to black treating hematochezia, metrorrhagia, puerperal blood faints.
Radix Dipsaci: be the dry root of Dipsacaceae plant Radix Dipsaci Dipsacus asperoides C.Y.Cheng etT.M.Ai..Bitter in the mouth; Pungent; Slightly warm in nature.Return liver; Kidney channel.Invigorating the liver and kidney; Bone and muscle strengthening; Blood circulation regulating; Continuous injured; Only metrorrhagia.For aching pain in waist and back; Podomere flaccidity syndrome and arthralgia syndrome; Fall flutter wound, damage muscle folding bone, red, metrorrhagia is leaked in fetal movement, seminal emission, leukorrhagia, carbuncle skin ulcer swell.Prepared RADIX DIPSACI with yellow rice wine is used for rheumatic arthralgia, injury from falling down.Prepared RADIX DIPSACI with salt solution is used for soreness of the waist and knees.
Fructus Gleditsia (Fructus Gleditsia) (Gleditsia sinensis Lam): return through lung; Large intestine channel.Effect: expelling phlegm for arresting cough; Have one's ideas straightened out to lead to and close; Parasite killing eliminating stagnation.Cure mainly: productive cough dyspnea with fullness of the chest; Apoplexy locked mouth; Accumulation and obstruction of sputum; Coma in silence; Epilepsy; Sore throat; Constipation and anuresis; Carbuncle scabies.
Radix Mirabilis: be the tuber of Nyctaginaceae plant Mirabilis jalapa.Nature and flavor: sweetness and bitterness are flat.Function cures mainly: diuresis, purges heat, promoting blood circulation to remove blood stasis.Control stranguria with turbid discharge, leukorrhagia, impairment of the lung caused by overstrain is spitted blood, carbuncle carbuncle on the back, acute arthritis.
Folium Et Cacumen Murrayae: different name Radix Buddlejae Butterflybush, Murraya paniculata (L.) Jack., five li of perfume (or spice), Clausena excavata Burm.f., water Rohdea japonica Roth, tetramerous jasminorange leaf, the moon Fructus Citri tangerinae.For the stem and leaf of rutaceae Folium Et Cacumen Murrayae.Nature and flavor: acrid in the mouth, micro-hardship, warm in nature.GUIXIN, liver, lung meridian.Function cures mainly: circulation of qi promoting, invigorates blood circulation, and dispels the wind, dehumidifying, and has analgesia to act on.Main gastral cavity abdomen pain due to disorder of QI, tumbling and swelling, Jie skin ulcer, skin pruritus.
Lignum Pini Nodi: another name yellow pine knaur, Pine Nodular Branch, loose youth's head; Medical material Ji Yuan is the tuberosity of the branchs such as pinaceae plant Pinus tabuliformis, Pinus massoniana Lamb, Pinus densiflora, pinus yunnanensis faranch.Property bitter, temperature, returns Liver Channel.Effect is dispeiling pathogenic wind and removing dampness, pain relieving.For main anemofrigid-damp arthralgia, severe and migratory arthralgia pain; Foot numbness flaccidity is soft; Traumatic pain.
Celastrus orbiculatus Thunb.: different name is crossed mountain phoenix, hung wide whip, XIANGLONGCAO, Cortex Ampelopsis Aconitifoliae Radicis, Lobaria pulmonaria (L.) Hoffm., Rhizoma Dioscoreae Nipponicae, old tendon Bovis seu Bubali etc.For the rattan of Celastraceae plant Celastrus orbiculatus Thunb..Nature and flavor: micro-pungent, temperature, nontoxic (" conventional Chinese herbal medicine formula ").Function cures mainly: wind-damp dispelling, network of invigorating blood circulation.Control bones and muscles pain, numb limbs and tense tendons, infantile convulsion, acute filthy disease, dysentery.
Chinese medicine composition of the present invention is based on the pathogenetic research of the deep layer of inventor to apoplexy and Therapeutic Principle thereof, simultaneously according to inventor's clinical experience and pharmaceutical research achievement for many years, filter out the crude drug of Tongluo Futan, dispelling pathogenic wind and eliminating phlegm, the strong muscle of the kidney invigorating, benefiting QI and nourishing blood, form according to certain weight proportion prescription.
There is effect of better blood circulation promoting and blood stasis dispelling, dispelling pathogenic wind and eliminating phlegm: Lignum Sappan 3-9 part when adding the crude drug of following weight portion in the present invention in drug composition, Herba Syneilesis Aconitifoliae 2-7 part; Preferably, the weight portion of each raw material is: Lignum Sappan 8 parts, Herba Syneilesis Aconitifoliae 6 parts.
Lignum Sappan: be the dry duramen of pulse family (Fabaceae) Spruce beetle (Caesalpinia) plant Lignum Sappan C.sappan.There is promoting the circulation of blood dredging collateral, stasis-dispelling and pain-killing, effect of loose wind and blood.
Herba Syneilesis Aconitifoliae: be root or the herb of feverfew Herba Syneilesis Aconitifoliae, have removing toxic substances to invigorate blood circulation, dispel wind and remove dampness, effect of reducing swelling and alleviating pain.
In side of the present invention, each medicine compatibility plays effect of Tongluo Futan, dispelling pathogenic wind and eliminating phlegm, the strong muscle of the kidney invigorating, benefiting QI and nourishing blood, hard masses softening and resolving together altogether, is treatment neuropathy, apoplexy, hemiplegia acute stage, the efficient good medicine of convalescent period and sequela.Observe through long term clinical results, the experimentation of the aspects such as pharmacology and biochemistry.Clinical proof this product has blood vessel dilating, improves microcirculation, increases blood flow, regulates function of nervous system, increases neurotrophy, promotes nerve metabolism, repairs the effects such as neurocyte function.Function with cure mainly: blood circulation promoting and blood stasis dispelling, clearing away heat and nourishing YIN, vigorate qi and replenish the blood, strengthening the spleen to promote digestion, with with thromboangiitis obliterans, venous thrombosis, arteriosclerosis, cerebral thrombosis and hemorrhagic and ischemic sequelae (hemiplegia, hemiplegia, deviation of the mouth with numbness and paralysis, slobbering, slurred speech, stupor, swollen foot and knee, walks difficult, carpopedal spasm, coronary heart disease, amyotrophy, facial spasm, brain injury sequela, neuropathy, radiation disease is unable).
Chinese medicine composition of the present invention is nontoxic, safe and reliable, has no adverse reaction after taking, Clinical practice safety.
The present invention's each taste crude drug used can be bought at pharmacy and obtain.
Medicine activity component of the present invention can add various adjuvants required when preparing different dosage form, such as disintegrating agent, lubricant, adhesive etc., be prepared into the suitable clinical oral administration preparation of any one with the method for Chinese medicinal of routine, described oral formulations can be pill, powder, granule, capsule, tablet, oral liquid, drop pill etc.
A kind of preparation method of Chinese medicine composition of the present invention: after being taken by described weight by each crude drug of the present invention, pulverize, sieve (can be such as 80-300 mesh sieve), to obtain final product.Certainly, after also each crude drug can being pulverized, add the adjuvant needed for preparations shaping or excipient, be conventionally prepared into capsule, tablet or pill.
The another kind of preparation method of Chinese medicine composition of the present invention: take each crude drug by described weight portion; By each crude drug soak by water, merge decoction liquor, filter, filtrate is condensed into clear paste, and add adjuvant or the excipient of preparations shaping, preparations shaping, to obtain final product.
The usage of Chinese medicine composition of the present invention and consumption: dosage of the present invention depends on the factor such as age, health status of concrete dosage form, patient.As guidance: usage and dosage: capsule, each capsule is containing 0.3 gram of crude drug, and oral 3 to 4 at every turn, 3 times on the one 15 days is a course for the treatment of.
Detailed description of the invention
The present invention is further described below in conjunction with specific embodiment; these embodiments are only exemplary; what those skilled in the art should understand that is; can modify to the details of technical solution of the present invention and form lower without departing from the spirit and scope of the present invention or replace, but these amendments and replacement all fall within the scope of protection of the present invention.
The preparation of embodiment 1 capsule
Each crude drug (unit: g): Herba Schizonepetae 12, Radix Dipsaci 10, Radix Mirabilis 10, Fructus Gleditsia 5, Folium Et Cacumen Murrayae 2, Lignum Pini Nodi 2, Celastrus orbiculatus Thunb. 2, Radix Glycyrrhizae 1 is taken by following weight;
Above-mentioned each crude drug is decocted with water secondary, and add water 4 times of weight for the first time, decocts 2 hours, and add water 5 times of weight for the second time, decocts 1.5 hours; By decoction liquor merge, filter, it is 1.17-1.19(60 DEG C that filtrate is concentrated into relative density) clear paste; Merge twice clear paste, add appropriate amount of starch, mixing, dry, pulverize, add appropriate amount of ethanol and make granule, dry, granulate, filled capsules, to obtain final product.
The preparation of embodiment 2 capsule
Each crude drug (unit: g): Herba Schizonepetae 28, Radix Dipsaci 25, Radix Mirabilis 25, Fructus Gleditsia 15, Folium Et Cacumen Murrayae 10, Lignum Pini Nodi 8, Celastrus orbiculatus Thunb. 8, Radix Glycyrrhizae 6 is taken by following weight;
Above-mentioned each crude drug is decocted with water secondary, and add water 6 times of weight for the first time, decocts 2 hours, and add water 4 times of weight for the second time, decocts 1.5 hours; By decoction liquor merge, filter, it is 1.17-1.19(60 DEG C that filtrate is concentrated into relative density) clear paste; Merge twice clear paste, add appropriate amount of starch, mixing, dry, pulverize, add appropriate amount of ethanol and make granule, dry, granulate, filled capsules, to obtain final product.
The preparation of embodiment 3 capsule
Each crude drug (unit: g): Herba Schizonepetae 20, Radix Dipsaci 18, Radix Mirabilis 16, Fructus Gleditsia 12, Folium Et Cacumen Murrayae 8, Lignum Pini Nodi 6, Celastrus orbiculatus Thunb. 6, Radix Glycyrrhizae 2 is taken by following weight;
Above-mentioned each crude drug is decocted with water secondary, and add water 4 times of weight for the first time, decocts 2 hours, and add water 5 times of weight for the second time, decocts 1.5 hours; By decoction liquor merge, filter, it is 1.30-1.35(55 DEG C that filtrate is concentrated into relative density) clear paste; Merge twice clear paste, add appropriate amount of starch, mixing, dry, pulverize, add appropriate amount of ethanol and make granule, dry, granulate, filled capsules, to obtain final product.
The preparation of embodiment 4 capsule
Each crude drug (unit: g): Herba Schizonepetae 12, Radix Dipsaci 10, Radix Mirabilis 10, Fructus Gleditsia 5, Folium Et Cacumen Murrayae 2, Lignum Pini Nodi 2, Celastrus orbiculatus Thunb. 2, Radix Glycyrrhizae 1, Lignum Sappan 3, Herba Syneilesis Aconitifoliae 2 is taken by following weight;
Above-mentioned each crude drug is decocted with water secondary, and add water 4 times of weight for the first time, decocts 2 hours, and add water 5 times of weight for the second time, decocts 1.5 hours; By decoction liquor merge, filter, it is 1.30-1.35(55 DEG C that filtrate is concentrated into relative density) clear paste; Merge twice clear paste, add appropriate amount of starch, mixing, dry, pulverize, add appropriate amount of ethanol and make granule, dry, granulate, filled capsules, to obtain final product.
The preparation of embodiment 5 capsule
Each crude drug (unit: g): Herba Schizonepetae 28, Radix Dipsaci 25, Radix Mirabilis 25, Fructus Gleditsia 15, Folium Et Cacumen Murrayae 10, Lignum Pini Nodi 8, Celastrus orbiculatus Thunb. 8, Radix Glycyrrhizae 6, Lignum Sappan 9, Herba Syneilesis Aconitifoliae 7 is taken by following weight;
Above-mentioned each crude drug is decocted with water secondary, and add water 6 times of weight for the first time, decocts 2 hours, and add water 4 times of weight for the second time, decocts 1.5 hours; By decoction liquor merge, filter, it is 1.17-1.19(60 DEG C that filtrate is concentrated into relative density) clear paste; Merge twice clear paste, add appropriate amount of starch, mixing, dry, pulverize, add appropriate amount of ethanol and make granule, dry, granulate, filled capsules, to obtain final product.
The preparation of embodiment 6 capsule
Each crude drug (unit: g): Herba Schizonepetae 20, Radix Dipsaci 18, Radix Mirabilis 16, Fructus Gleditsia 12, Folium Et Cacumen Murrayae 8, Lignum Pini Nodi 6, Celastrus orbiculatus Thunb. 6, Radix Glycyrrhizae 2, Lignum Sappan 8, Herba Syneilesis Aconitifoliae 6 is taken by following weight;
Above-mentioned each crude drug is decocted with water secondary, and add water 6 times of weight for the first time, decocts 2 hours, and add water 4 times of weight for the second time, decocts 1.5 hours; By decoction liquor merge, filter, it is 1.17-1.19(60 DEG C that filtrate is concentrated into relative density) clear paste; Merge twice clear paste, add appropriate amount of starch, mixing, dry, pulverize, add appropriate amount of ethanol and make granule, dry, granulate, filled capsules, to obtain final product.
The preparation of embodiment 7 watered pill
Each crude drug (unit: g): Herba Schizonepetae 20, Radix Dipsaci 18, Radix Mirabilis 16, Fructus Gleditsia 12, Folium Et Cacumen Murrayae 8, Lignum Pini Nodi 6, Celastrus orbiculatus Thunb. 6, Radix Glycyrrhizae 2, Lignum Sappan 8, Herba Syneilesis Aconitifoliae 6 is taken by following weight;
Above-mentioned each crude drug is decocted with water secondary, and add water 6 times of weight for the first time, decocts 2 hours, and add water 4 times of weight for the second time, decocts 1.5 hours; By decoction liquor merge, filter, it is 1.17-1.19(60 DEG C that filtrate is concentrated into relative density) clear paste; Merge twice clear paste, make binding agent with water, generally make the watered pill, dry, subpackage, packaging, gets product.
The preparation of embodiment 8 water-honeyed pill
Each crude drug (unit: g): Herba Schizonepetae 20, Radix Dipsaci 18, Radix Mirabilis 16, Fructus Gleditsia 12, Folium Et Cacumen Murrayae 8, Lignum Pini Nodi 6, Celastrus orbiculatus Thunb. 6, Radix Glycyrrhizae 2, Lignum Sappan 8, Herba Syneilesis Aconitifoliae 6 is taken by following weight;
Mixed by each crude drug and be ground into fine powder, cross 100 mesh sieves, get appropriate refined honey, make binding agent with refined honey, water, generally make water-honeyed pill, dry, subpackage, packaging, gets product.
The clinical observation on the therapeutic effect test of test example 1 traditional Chinese medicine composition for treating apoplectic hemiplegia of the present invention
One, physical data: the 136 routine patients that outpatient service is accepted for medical treatment all meet the clinical criteria of apoplectic hemiplegia, and 136 routine patients are divided into 2 groups at random, often organizes 68 examples; 2 groups of no significant differences on sex, age, the course of disease and coincident with severity degree of condition.
Two, trial drug
Medicine prepared by embodiment of the present invention 1-8.
Three, Therapeutic Method
136 patients are divided into 2 groups respectively at random, that is: test 1 group and test 2, often organize each 68 example, test 1 group adopt prepared by embodiment 1-3 capsule treatment, test 2 groups adopt prepared by embodiment 4-6 capsule treatment; Oral, one time 4 (0.3g crude drug/grain), 3 times on the one 15 days is a course for the treatment of, treats 6 courses for the treatment of altogether.
Four, efficacy assessment standard
Effective: hemiplegia symptom disappears substantially, patient can walk, and life is taken care of oneself substantially;
Effective: hemiplegia symptom takes a turn for the better to some extent, language function is normal, and crutch can be leaned on to walk;
Invalid: hemiplegia symptom is without any improvement.
Five, clinical observation result
Clinical observation result is in table 1.
The clinical observation on the therapeutic effect result of the test of table 1 traditional Chinese medicine composition for treating apoplectic hemiplegia of the present invention
Clinical observation on the therapeutic effect result shows, Chinese medicine composition of the present invention has significant curative effect for Hemiplegic Patients; Wherein, the therapeutic effect testing 2 groups significantly will be better than the therapeutic effect of test 1 group; Safety observations find, do not observe any clinical adverse, show Chinese medicine composition clinical practice of the present invention safely, have no side effect.
Claims (7)
1. treat the Chinese medicine composition of apoplectic hemiplegia for one kind, it is characterized in that, be made up of each crude drug of following weight portion: Herba Schizonepetae 12-28 part, Radix Dipsaci 10-25 part, Radix Mirabilis 10-25 part, Fructus Gleditsia 5-15 part, Folium Et Cacumen Murrayae 2-10 part, Lignum Pini Nodi 2-8 part, Celastrus orbiculatus Thunb. 2-8 part and Radix Glycyrrhizae 1-6 part.
2. according to Chinese medicine composition according to claim 1, it is characterized in that, the weight portion of each crude drug is: Herba Schizonepetae 20 parts, Radix Dipsaci 18 parts, Radix Mirabilis 16 parts, 12 parts, Fructus Gleditsia, Folium Et Cacumen Murrayae 8 parts, Lignum Pini Nodi 6 parts, Celastrus orbiculatus Thunb. 6 parts, 2 parts, Radix Glycyrrhizae.
3. treat the Chinese medicine composition of apoplectic hemiplegia for one kind, it is characterized in that, be made up of each crude drug of following weight portion: Herba Schizonepetae 12-28 part, Radix Dipsaci 10-25 part, Radix Mirabilis 10-25 part, Fructus Gleditsia 5-15 part, Folium Et Cacumen Murrayae 2-10 part, Lignum Pini Nodi 2-8 part, Celastrus orbiculatus Thunb. 2-8 part, Radix Glycyrrhizae 1-6 part, Lignum Sappan 3-9 part, Herba Syneilesis Aconitifoliae 2-7 part.
4. according to Chinese medicine composition according to claim 3, it is characterized in that, the weight portion of each crude drug is: Herba Schizonepetae 20 parts, Radix Dipsaci 18 parts, Radix Mirabilis 16 parts, 12 parts, Fructus Gleditsia, Folium Et Cacumen Murrayae 8 parts, Lignum Pini Nodi 6 parts, Celastrus orbiculatus Thunb. 6 parts, 2 parts, Radix Glycyrrhizae, Lignum Sappan 8 parts, Herba Syneilesis Aconitifoliae 6 parts.
5. prepare a method for claim 1-4 Chinese medicine composition described in any one, comprise the following steps:
(1), each crude drug is taken by described weight proportion;
(2), by each crude drug soak by water, merge decoction liquor, filter, filtrate is condensed into clear paste, adds the adjuvant of preparations shaping, preparations shaping, to obtain final product.
6. prepare a method for claim 1-4 Chinese medicine composition described in any one, comprise the following steps: by each component, pulverize, sieve, add the adjuvant needed for preparations shaping, be conventionally prepared into capsule, tablet or pill.
7. the purposes of claim 1-4 Chinese medicine composition described in any one in preparation treatment apoplectic hemiplegia medicine.
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