CN105169057A - Preparation for treating cerebral cancer and preparation method - Google Patents
Preparation for treating cerebral cancer and preparation method Download PDFInfo
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- CN105169057A CN105169057A CN201510625269.3A CN201510625269A CN105169057A CN 105169057 A CN105169057 A CN 105169057A CN 201510625269 A CN201510625269 A CN 201510625269A CN 105169057 A CN105169057 A CN 105169057A
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Abstract
The invention discloses a preparation for treating cerebral cancer. The preparation is mainly prepared from, by mass, 9-14 parts of selfheal, 7-15 parts of kumquat roots, 6-12 parts of trogopterus dung, 8-15 parts of roots of myriactis nepalensis, 12-18 parts of drumfish, 10-16 parts of phoenix hawksbeard roots, 9-15 parts of chlorophytum comosum, 7-13 parts of roots of kerr treebine, 8-12 parts of sago seeds, 9-13 parts of herb of himalayan willow weed, 7-12 parts of Chinese honey locust seeds, 6-13 parts of konjak, 9-16 parts of eragrostis pilosa, 10-17 parts of tremella fuciformis, 8-13 parts of ternate buttercup roots, 9-12 parts of dysosma versipellis and 7-11 parts of fruits of duhat. The preparation is a traditional Chinese medicine preparation, selected materials are safe, the preparation has no toxic or side effect, is prepared according to the traditional Chinese medicine rule, has the effects of removing stasis, dredging collaterals, achieving disintoxication, removing extravasted blood and the like, can effectively suppress focus transfer and can achieve treatment in cooperation with operation or chemoradiotherapy, and the living quality of a patient is improved.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to a kind of preparation and method for making for the treatment of the brain cancer.
Background technology
The cerebral tumor is also known as intracranial tumor, and the tumor being grown on intracranial is commonly referred to as cerebroma, comprises the primary brain tumor occurred by brain essence and the Secondary cases cerebroma being transferred to intracranial by other positions of health.Its unknown etiology as yet, tumor occurs from brain, meninges, hypophysis cerebri, cranial nerve, cerebrovascular and embryonal rest organizer, is called Primary intracranial tumor.By the Malignant tumor of bonal metastasis of other organs and tissues of health to intracranial person, be called Secondary cases intracranial tumor.Intracranial tumor can betide any age, is the most common with 20-50 year.Symptom has headache, vomiting, epilepsy, nerve and disturbance of consciousness and bregma bulge, head circumference increase and separation of cranial etc.Western medical treatment is main and auxiliary with radiation and the Comprehensive Treatment of chemotherapy with operative treatment.Benign tumor is carried out performing the operation and can be reached the effect of healing.And for malignant tumor, the treatment such as operation and chemicotherapy only can reach the effect delaying to recur.
Publication No. CN104013833A(application number 201410280147.0) Chinese patent literature disclose a kind of pharmaceutical composition for the treatment of the brain cancer, be made up of the raw material of following weight ratio, Fructus Viticis 12-24 part, Semen Sinapis Albae 12-24 part, Ramulus Uncariae Cum Uncis 12-24 part, Flos Carthami 12-24 part, Rhizoma Chuanxiong 12-24 part, Radix Salviae Miltiorrhizae 12-24 part, Rhizoma Gastrodiae 12-24 part, Radix Polygoni Multiflori 12-24 part, Rhizoma Cimicifugae 12-24 part, Sanguis Draxonis 9-21 part, Scolopendra 9-21 part, Semen Persicae 9-21 part, Squama Manis 9-21 part, Radix Notoginseng 9-21 part, Borneolum Syntheticum 9-21 part, Indigo Naturalis 9-21 part, Calomelas 9-21 part be combined as active component.Publication No. CN103272109A(application number 201310241277.9) Chinese patent literature disclose a kind of medicament for the treatment of the brain cancer, consist of Rhizoma Arisaematis 20-50 part, Radix Gei japonici 50-70 part, Rhizoma Paridis 12-15 part, Fructus Forsythiae 20-25 part, Spica Prunellae 20-30 part, Radix Rehmanniae 20-25 part, Radix Cudraniae 20-25 part, Rhizoma Dioscoreae 15-21 part, Os Draconis 20-25 part, Semen Juglandis 20-30 part and Rhizoma Pinelliae 15-20 part.
The western medical treatment brain cancer, large to body injury, somewhat expensive, be unsuitable for all patients, and the traditional Chinese medical science formula weak curative effect of the traditional treatment brain cancer, DeGrain, the traditional Chinese medical science formula of the associated therapy brain cancer is very few on the market, therefore for removing patient suffering, the traditional Chinese medical science formula developing a kind of effective treatment brain cancer is needed.
Summary of the invention
For the deficiencies in the prior art, the object of this invention is to provide preparation and the method for making of the high treatment brain cancer of a kind of determined curative effect, safety.
Technical scheme of the present invention is:
The preparation of the treatment brain cancer, is prepared from primarily of following bulk drugs, is mass parts: Spica Prunellae 9-14, Radix Fortunellae Margaritae 7-15, Oletum Trogopterori 6-12, oil head grass 8-15, Carnis Pseudosciaenae 12-18, Crepis crocea Babc.(C.turczaninowii C.A.Mey.) 10-16, bracketplant 9-15, Radix Cissi Kerrii 7-13, Cycas revoluta Thunb. 8-12, Herba Epilobii Himalayensis 9-13, Semen Gleditsiae 7-12, Rhizoma amorphophalli 6-13, Herba Eragrostidis pilosae 9-16, Tremella 10-17, Radix Ranunculi Ternati 8-13, Radix et Rhizoma Dysosmatis 9-12, sheep dung fruit 7-11.
In preferred scheme, Spica Prunellae 10-13, Radix Fortunellae Margaritae 9-13, Oletum Trogopterori 8-10, oil head grass 10-13, Carnis Pseudosciaenae 14-16, Crepis crocea Babc.(C.turczaninowii C.A.Mey.) 12-14, bracketplant 10-14, Radix Cissi Kerrii 9-11, Cycas revoluta Thunb. 9-11, Herba Epilobii Himalayensis 10-12, Semen Gleditsiae 9-10, Rhizoma amorphophalli 8-11, Herba Eragrostidis pilosae 11-14, Tremella 12-15, Radix Ranunculi Ternati 10-11, Radix et Rhizoma Dysosmatis 10-11, sheep dung fruit 8-10.
Be more preferably, Spica Prunellae 11.5, Radix Fortunellae Margaritae 11, Oletum Trogopterori 9, oil head grass 11.5, Carnis Pseudosciaenae 15, Crepis crocea Babc.(C.turczaninowii C.A.Mey.) 13, bracketplant 12, Radix Cissi Kerrii 10, Cycas revoluta Thunb. 10, Herba Epilobii Himalayensis 11, Semen Gleditsiae 9.5, Rhizoma amorphophalli 9.5, Herba Eragrostidis pilosae 12.5, Tremella 13.5, Radix Ranunculi Ternati 10.5, Radix et Rhizoma Dysosmatis 10.5, sheep dung fruit 9.
The preparation of the described treatment brain cancer, be made into pharmaceutically acceptable decoction, its preparation method is:
(1) Spica Prunellae and Rhizoma amorphophalli are cut into small pieces, reinstate saline with Semen Gleditsiae one and clean, add Radix Glycyrrhizae and mix thoroughly, to be placed in steamer Steam by water bath thoroughly after, take out, removing Radix Glycyrrhizae, dries;
(2) get Cycas revoluta Thunb. and sheep dung fruit clean, be cut into small pieces, pull out after flooding 20 minutes with sweet wine, Testa Tritici is sprinkled in frying pan and is heated to smolder, put into crude drug, constantly stir-fry to crude drug surface micro-Huang, take out, sieve remove Testa Tritici, dry;
(3) bracketplant, Radix et Rhizoma Dysosmatis and Radix Ranunculi Ternati roguing are cleaned, boil 15 minutes with rice-washed water big fire, take out, dry, then boil 10 minutes with vinegar, take out, dry;
(4) Radix Fortunellae Margaritae, Oletum Trogopterori, oil head grass, Carnis Pseudosciaenae, Crepis crocea Babc.(C.turczaninowii C.A.Mey.), Radix Cissi Kerrii, Herba Epilobii Himalayensis, Herba Eragrostidis pilosae and Tremella roguing are cleaned, decoct with water together with step (1) (2) (3) made crude drug, turn a little fire after big fire boils 10 minutes to decoct 20-35 minute (preferred, 25-30 minute decocted by little fire; Be more preferably, little fire decocts 27 minutes), filter, collect filtrate, obtain decoction.
The preparation method of the preparation decoction of the described treatment brain cancer, the 5-7 that step (4) amount of water is boiled crude drug quality is (preferred, amount of water is 6 times of boiled crude drug quality) doubly.
The preparation of the described treatment brain cancer, be made into pharmaceutically acceptable powder, its preparation method is:
(1) Spica Prunellae and Rhizoma amorphophalli are cut into small pieces, reinstate saline with Semen Gleditsiae one and clean, add Radix Glycyrrhizae and mix thoroughly, to be placed in steamer Steam by water bath thoroughly after, take out, removing Radix Glycyrrhizae, dries;
(2) get Cycas revoluta Thunb. and sheep dung fruit clean, be cut into small pieces, pull out after flooding 20 minutes with sweet wine, Testa Tritici is sprinkled in frying pan and is heated to smolder, put into crude drug, constantly stir-fry to crude drug surface micro-Huang, take out, sieve remove Testa Tritici, dry, pulverize make medicated powder;
(3) bracketplant, Radix et Rhizoma Dysosmatis and Radix Ranunculi Ternati roguing are cleaned, boil 15 minutes with rice-washed water big fire, take out, dry, then boil 10 minutes with vinegar, take out, dry;
(4) Radix Fortunellae Margaritae, Oletum Trogopterori, oil head grass, Carnis Pseudosciaenae, Crepis crocea Babc.(C.turczaninowii C.A.Mey.), Radix Cissi Kerrii, Herba Epilobii Himalayensis, Herba Eragrostidis pilosae and Tremella roguing are cleaned, decoct with water together with step (1) (3) made crude drug, amount of water is 8 times of boiled crude drug quality, turn a little fire after big fire boils 10 minutes to decoct 20-35 minute (preferred, 25-30 minute decocted by little fire; Be more preferably, little fire decocts 27 minutes), filter, filtering residue adds water and again decocts, and merges twice and decocts gained filtrate, concentrated, dry, pulverize and makes medicated powder, mix, obtain powder with step (2) made medicated powder.
The preparation method of the preparation powder of the described treatment brain cancer, step (4) pulverized 100-140 mesh sieve (preferred, to pulverize 120 mesh sieves).
The preparation of the described treatment brain cancer, be made into pharmaceutically acceptable granule, its preparation method is:
(1) Spica Prunellae and Rhizoma amorphophalli are cut into small pieces, reinstate saline with Semen Gleditsiae one and clean, add Radix Glycyrrhizae and mix thoroughly, to be placed in steamer Steam by water bath thoroughly after, take out, removing Radix Glycyrrhizae, dries;
(2) get Cycas revoluta Thunb. and sheep dung fruit clean, be cut into small pieces, pull out after flooding 20 minutes with sweet wine, Testa Tritici is sprinkled in frying pan and is heated to smolder, put into crude drug, constantly stir-fry to crude drug surface micro-Huang, take out, sieve remove Testa Tritici, dry, pulverize make medicated powder;
(3) bracketplant, Radix et Rhizoma Dysosmatis and Radix Ranunculi Ternati roguing are cleaned, boil 15 minutes with rice-washed water big fire, take out, dry, then boil 10 minutes with vinegar, take out, dry;
(4) Radix Fortunellae Margaritae, Oletum Trogopterori, oil head grass, Carnis Pseudosciaenae, Crepis crocea Babc.(C.turczaninowii C.A.Mey.), Radix Cissi Kerrii, Herba Epilobii Himalayensis, Herba Eragrostidis pilosae and Tremella roguing are cleaned, decoct with water together with step (1) (3) made crude drug, amount of water is 8 times of boiled crude drug quality, turn little fire after big fire boils 10 minutes to decoct, filter, filtering residue adds water and again decocts, merge twice and decoct gained filtrate, concentrated, dry, pulverize and make medicated powder;
(5) by made to step (2) (4) medicated powder mixing, with sucrose and dried starch mixing, add starch slurry soft material, granulate, dry, granulate, obtains granule.
The preparation method of the preparation granules agent of the described treatment brain cancer, turns a little fire and decocts 20-35 minute (preferred, 25-30 minute decocted by little fire after step (4) big fire boils 10 minutes; Be more preferably, little fire decocts 27 minutes).
The preparation of the described treatment brain cancer, be made into pharmaceutically acceptable capsule, its preparation method is:
(1) Spica Prunellae and Rhizoma amorphophalli are cut into small pieces, reinstate saline with Semen Gleditsiae one and clean, add Radix Glycyrrhizae and mix thoroughly, to be placed in steamer Steam by water bath thoroughly after, take out, removing Radix Glycyrrhizae, dries;
(2) get Cycas revoluta Thunb. and sheep dung fruit clean, be cut into small pieces or mash, pulling out after flooding 20 minutes with sweet wine, Testa Tritici is sprinkled in frying pan and is heated to smolder, put into crude drug, constantly stir-fry to crude drug surface micro-Huang, take out, sieve remove Testa Tritici, dry;
(3) bracketplant, Radix et Rhizoma Dysosmatis and Radix Ranunculi Ternati roguing are cleaned, boil 15 minutes with rice-washed water big fire, take out, dry, then boil 10 minutes with vinegar, take out, dry;
(4) Radix Fortunellae Margaritae, Oletum Trogopterori, oil head grass, Carnis Pseudosciaenae, Crepis crocea Babc.(C.turczaninowii C.A.Mey.), Radix Cissi Kerrii, Herba Epilobii Himalayensis, Herba Eragrostidis pilosae and Tremella roguing are cleaned, decoct with water together with step (1) (3) made crude drug, amount of water is 8 times of boiled crude drug quality, turn a little fire after big fire boils 10 minutes to decoct 20-35 minute (preferred, 25-30 minute decocted by little fire; Be more preferably, little fire decocts 27 minutes), filter, filtering residue adds water and again decocts, and merges twice and decocts gained filtrate, concentrated, dry;
(5) step (2) (4) made crude drug is pulverized together with dry thing make medicated powder, with sucrose and dried starch mixing, add starch slurry soft material, obtain granule, incapsulate, obtain capsule.
The preparation method of the preparation capsule of the described treatment brain cancer, step (5) was pulverized 100-200 mesh sieve and (preferably, was pulverized 130-170 mesh sieve; Be more preferably, pulverized 150 mesh sieves).
The formulation science selection of the treatment brain cancer provided by the invention, prescription is rigorous, and method is simple, product taking convenience.In addition, excellent results of the present invention also shows:
1, the present invention is Chinese medicine preparation, and selection safety is without any side effects;
2, this prescription is according to the development of Chinese medicine principle, has the effect such as resolving mass and removing the obstruction of the collateral, eliminating toxic substances to remove stasis;
3, good effect of the present invention, can effectively suppress focus to shift, and can treat in conjunction with operation or chemicotherapy, improves life in patients.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Spica Prunellae: base is former: be the fruit ear of labiate Spica Prunellae.Nature and flavor: toil, cold.Gui Jing: enter liver, gallbladder meridian.Function cures mainly: liver heat removing, eliminating stagnation.Control scrofula, goiter, acute mastitis, breast carcinoma, order pearl nyctalgia, photophobia is shed tears, the vertigo, facial hemiparalysis, bones and muscles pain, pulmonary tuberculosis, acute icteric infectious hepatitis, metrorrhagia, leukorrhagia.
Radix Fortunellae Margaritae: base is former: be the root of rutaceae Fructus Fortunellae Margaritae and golden bullet.Nature and flavor: bitter, temperature.Function cures mainly: circulation of qi promoting, eliminating stagnation.Treat for stomachache and tell food, scrofula, hernia, puerperal abdonimal pain, uterine prolapse.
Oletum Trogopterori: base is former: be the dry feces of flying squirrel section animal trogopterus xanthipes and flying squirrel etc.Nature and flavor: bitter sweet, temperature.Gui Jing: enter liver, spleen channel.Function cures mainly: life promoting the circulation of blood pain relieving.Control all pains of trusted subordinate's vim and vigour, women's amenorrhea, postnatal blood stasis is had a pain, external treatment Serpentis, scorpion, centipete bite.Stir-fry is stopped blooding.Control metrorrhagia, menorrhagia, leucorrhea with bloody discharge is without cease.
Oil head grass: base is former: for feverfew circle tongue glues root or the herb of hat grass.Nature and flavor: taste is micro-pungent, property is put down.Function cures mainly: heat-clearing and toxic substances removing, elegant rash, pain relieving.Main dysentery, enteritis, otitis media, measles is sent out not smooth thoroughly, toothache, arthralgia.
Carnis Pseudosciaenae: base is former: be the meat of Sciaenidae animal Carnis Pseudosciaenae or Carnis Pseudosciaenae.Nature and flavor: sweet in the mouth, property is put down.Gui Jing: return spleen, stomach, liver, kidney channel.Function cures mainly: replenishing QI to invigorate the spleen, the kidney invigorating, improving eyesight, dysentery relieving.Main after being ill, puerperal asthenia, hypogalactia, lumbago due to renal deficiency, edema, blurring of vision, headache, stomachache, dysentery.
Crepis crocea Babc.(C.turczaninowii C.A.Mey.): base is former: be the root of feverfew Crepis phoenix Dunn.Nature and flavor: bitter in the mouth, sweet, warm in nature.Function cures mainly: liver and kidney tonifying, invigorating spleen to remove dampness.Master has a dizzy spell, soreness of the waist and knees, edema, leukorrhagia infantile malnutrition, hypogalactia.
Bracketplant: base is former: be herb or the root of liliaceous plant bracketplant.Nature and flavor: sweet in the mouth, micro-hardship, cool in nature.Function cures mainly: preventing phlegm from forming and stopping coughing, dissipating blood stasis for subsidence of swelling, heat-clearing and toxic substances removing.Main phlegm-heat cough, traumatic injury, fracture, carbuncle, hemorrhoid, burn.
Radix Cissi Kerrii: base is former: be root and the ratan of vitaceae Cissus repens.Nature and flavor: sweetness and bitterness are cool.Function cures mainly: heat-clearing and toxic substances removing, eliminating stagnation, promoting the circulation of blood.Control nephritis, ulcer sores, tuberculous lymphadenitis, traumatic injury.
Cycas revoluta Thunb.: base is former: be the seed of cycad sago cycas.Nature and flavor: bitter, acid, property is put down, mild toxicity.Function cures mainly: removing dampness is fallen, invigorating the spleen and regulating the stomach, expelling phlegm for arresting cough.Main enteritis, dysentery, dyspepsia, singultus, tracheitis, bronchitis.
Herba Epilobii Himalayensis: base is former: be the herb of Folium Salicis Babylonicae Lay section plant Himalaya LIUYECAI.Nature and flavor: flat, lightly seasoned, nontoxic.Function cures mainly: wind and heat dispersing, dampness removing antidiarrheal, synthetism of invigorating blood circulation.Main headache due to pathogenic wind-heat, laryngopharynx swelling and pain, hoarseness, diarrhoea, amenorrhea, sore and toxic, injury and bone fracture.
Semen Gleditsiae: base is former: be the seed of leguminous plant Fructus Gleditsia.Nature and flavor: pungent, temperature, poisonous.Function cures mainly: moistening dryness for relaxing bowels, detumescence of dispeling the wind.Control the quick-fried knot of stool, discharging fresh blood stool, dysentery tenesmus, hernia, scrofula, toxic swelling, skin ulcer tinea.
Rhizoma amorphophalli: base is former: be aroid mill taro, the tuber dredging hair mill taro, wild mill taro, Rhizoma Amorphophalli.Nature and flavor: pungent, cold.Poisonous.Function cures mainly: dispersing swelling and dissipating binds, removing toxic substances pain relieving.For tumor, lymphoid tuberculosis, carbuncle furuncle and phyma poison is controlled in external, venom.
Herba Eragrostidis pilosae: base is former: be the herb of grass Herba Eragrostidis pilosae.Nature and flavor: sweet are light, cool.Function cures mainly: inducing diuresis for treating stranguria syndrome, heat clearing and blood circulation promoting.Main pyretic stranguria, stranguria caused by urinary stone, conjunctival congestion is itched bitterly, traumatic injury.
Tremella: base is former: be the sporophore of Tremellaceae Tremella.Nature and flavor: sweet are flat.Function cures mainly: invigorating the lung and benefiting vital QI, nourishing YIN to relieve dryness.For body is empty after being ill, chronic cough of deficiency lung, sputum mixed with blood, metrorrhagia, constipation, hypertension, sclerosis of blood vessels.
Radix Ranunculi Ternati: base is former: be the tuber of Herba Ranunculi Japonici kind of plant Seynuns Kugelann.Nature and flavor: pungent, bitter are flat.Slightly poisonous.Gui Jing: enter liver, lung two warp.Function cures mainly: removing toxic substances, eliminating stagnation.For pulmonary tuberculosis, tuberculous lymphadenitis, lymphadenitis, pharyngolaryngitis.
Radix et Rhizoma Dysosmatis: base is former: be rhizome and the root of Berberidaceae plant Radix et Rhizoma Dysosmatis.Nature and flavor: toil are flat, poisonous.Gui Jing: enter lung meridian.Function cures mainly: heat-clearing and toxic substances removing, dissipating phlegm and resolving masses, removing blood stasis to reduce swelling.Control carbuncle, furuncle, scrofula, throat moth, traumatic injury, venom.
Sheep dung fruit: base is former: be the fruit of myrtle crow ink.Nature and flavor: sweet in the mouth, acid, property is put down.Function cures mainly: astringing lung QI for relieving asthma, promotes the production of body fluid, astringing intestine to stop diarrhea.Main phthisical cough, dyspnea due to deficiency, Tianjin wound is thirsty, chronic diarrhea chronic dysentery.
embodiment 1the preparation of the treatment brain cancer, is prepared from (every part of 10g) primarily of following bulk drugs: Spica Prunellae 9 parts, Radix Fortunellae Margaritae 7 parts, Oletum Trogopterori 6 parts, oil head grass 8 parts, Carnis Pseudosciaenae 12 parts, Crepis crocea Babc.(C.turczaninowii C.A.Mey.) 10 parts, bracketplant 9 parts, Radix Cissi Kerrii 7 parts, Cycas revoluta Thunb. 8 parts, Herba Epilobii Himalayensis 9 parts, Semen Gleditsiae 7 parts, Rhizoma amorphophalli 6 parts, Herba Eragrostidis pilosae 9 parts, 10 parts, Tremella, Radix Ranunculi Ternati 8 parts, Radix et Rhizoma Dysosmatis 9 parts, sheep dung fruit 7 parts.
The preparation method of the preparation decoction of the above-mentioned treatment brain cancer is:
(1) Spica Prunellae and Rhizoma amorphophalli are cut into small pieces, reinstate saline with Semen Gleditsiae one and clean, add Radix Glycyrrhizae and mix thoroughly, to be placed in steamer Steam by water bath thoroughly after, take out, removing Radix Glycyrrhizae, dries;
(2) get Cycas revoluta Thunb. and sheep dung fruit clean, be cut into small pieces, pull out after flooding 20 minutes with sweet wine, Testa Tritici is sprinkled in frying pan and is heated to smolder, put into crude drug, constantly stir-fry to crude drug surface micro-Huang, take out, sieve remove Testa Tritici, dry;
(3) bracketplant, Radix et Rhizoma Dysosmatis and Radix Ranunculi Ternati roguing are cleaned, boil 15 minutes with rice-washed water big fire, take out, dry, then boil 10 minutes with vinegar, take out, dry;
(4) Radix Fortunellae Margaritae, Oletum Trogopterori, oil head grass, Carnis Pseudosciaenae, Crepis crocea Babc.(C.turczaninowii C.A.Mey.), Radix Cissi Kerrii, Herba Epilobii Himalayensis, Herba Eragrostidis pilosae and Tremella roguing are cleaned, decoct with water together with step (1) (2) (3) made crude drug, amount of water is 6 times of boiled crude drug quality, turn little fire after big fire boils 10 minutes and decoct 27 minutes, filter, collect filtrate, obtain decoction.
embodiment 2the preparation of the treatment brain cancer, is prepared from (every part of 10g) primarily of following bulk drugs: Spica Prunellae 14 parts, Radix Fortunellae Margaritae 15 parts, Oletum Trogopterori 12 parts, oil head grass 15 parts, Carnis Pseudosciaenae 18 parts, Crepis crocea Babc.(C.turczaninowii C.A.Mey.) 16 parts, bracketplant 15 parts, Radix Cissi Kerrii 13 parts, Cycas revoluta Thunb. 12 parts, Herba Epilobii Himalayensis 13 parts, Semen Gleditsiae 12 parts, Rhizoma amorphophalli 13 parts, Herba Eragrostidis pilosae 16 parts, 17 parts, Tremella, Radix Ranunculi Ternati 13 parts, Radix et Rhizoma Dysosmatis 12 parts, sheep dung fruit 11 parts.
The preparation method of the preparation powder of the treatment brain cancer is:
(1) Spica Prunellae and Rhizoma amorphophalli are cut into small pieces, reinstate saline with Semen Gleditsiae one and clean, add Radix Glycyrrhizae and mix thoroughly, to be placed in steamer Steam by water bath thoroughly after, take out, removing Radix Glycyrrhizae, dries;
(2) get Cycas revoluta Thunb. and sheep dung fruit clean, be cut into small pieces, pull out after flooding 20 minutes with sweet wine, Testa Tritici is sprinkled in frying pan and is heated to smolder, put into crude drug, constantly stir-fry to crude drug surface micro-Huang, take out, sieve remove Testa Tritici, dry, pulverize make medicated powder;
(3) bracketplant, Radix et Rhizoma Dysosmatis and Radix Ranunculi Ternati roguing are cleaned, boil 15 minutes with rice-washed water big fire, take out, dry, then boil 10 minutes with vinegar, take out, dry;
(4) Radix Fortunellae Margaritae, Oletum Trogopterori, oil head grass, Carnis Pseudosciaenae, Crepis crocea Babc.(C.turczaninowii C.A.Mey.), Radix Cissi Kerrii, Herba Epilobii Himalayensis, Herba Eragrostidis pilosae and Tremella roguing are cleaned, decoct with water together with step (1) (3) made crude drug, amount of water is 8 times of boiled crude drug quality, turns little fire and decoct 27 minutes after big fire boils 10 minutes, filter, filtering residue adds water and again decocts, and merges twice and decocts gained filtrate, concentrated, dry, pulverized 120 mesh sieves and made medicated powder, and mixed with step (2) made medicated powder, obtain powder.
Model case: xxx, female, 55 years old.Main suit: closely often feel headache over the past half year, slightly feel sick, pay attention to, symptom day by day increases the weight of, before one week, because One's head is splitting, delivers to examination in hospital with vomiting, through head B-sonography inspection, is diagnosed as brain end cancer.Patient's body constitution is not suitable for operation, then selects chemotherapy and tcm therapy treatment.
Take the preparation powder of the present embodiment gained treatment brain cancer, every day 2 times, each 5-7g, warm boiled water, 21 days courses for the treatment of.After taking a course for the treatment of, headache alleviates, and vomiting is eliminated, and after taking three courses for the treatment of, headache disappears, check, and focus is eliminated, and patient clinical is cured, and consolidates the drug withdrawal course for the treatment of, follows up a case by regular visits to patient and be still living and in good health after 2 years.
embodiment 3the preparation of the treatment brain cancer, is prepared from (every part of 10g) primarily of following bulk drugs: Spica Prunellae 10 parts, Radix Fortunellae Margaritae 9 parts, Oletum Trogopterori 8 parts, oil head grass 10 parts, Carnis Pseudosciaenae 14 parts, Crepis crocea Babc.(C.turczaninowii C.A.Mey.) 12 parts, bracketplant 10 parts, Radix Cissi Kerrii 9 parts, Cycas revoluta Thunb. 9 parts, Herba Epilobii Himalayensis 10 parts, Semen Gleditsiae 9 parts, Rhizoma amorphophalli 8 parts, Herba Eragrostidis pilosae 11 parts, 12 parts, Tremella, Radix Ranunculi Ternati 10 parts, Radix et Rhizoma Dysosmatis 10 parts, sheep dung fruit 8 parts.
The preparation method of the preparation granules agent of the treatment brain cancer is:
(1) Spica Prunellae and Rhizoma amorphophalli are cut into small pieces, reinstate saline with Semen Gleditsiae one and clean, add Radix Glycyrrhizae and mix thoroughly, to be placed in steamer Steam by water bath thoroughly after, take out, removing Radix Glycyrrhizae, dries;
(2) get Cycas revoluta Thunb. and sheep dung fruit clean, be cut into small pieces, pull out after flooding 20 minutes with sweet wine, Testa Tritici is sprinkled in frying pan and is heated to smolder, put into crude drug, constantly stir-fry to crude drug surface micro-Huang, take out, sieve remove Testa Tritici, dry, pulverize make medicated powder;
(3) bracketplant, Radix et Rhizoma Dysosmatis and Radix Ranunculi Ternati roguing are cleaned, boil 15 minutes with rice-washed water big fire, take out, dry, then boil 10 minutes with vinegar, take out, dry;
(4) Radix Fortunellae Margaritae, Oletum Trogopterori, oil head grass, Carnis Pseudosciaenae, Crepis crocea Babc.(C.turczaninowii C.A.Mey.), Radix Cissi Kerrii, Herba Epilobii Himalayensis, Herba Eragrostidis pilosae and Tremella roguing are cleaned, decoct with water together with step (1) (3) made crude drug, amount of water is 8 times of boiled crude drug quality, turn little fire after big fire boils 10 minutes and decoct 27 minutes, filter, filtering residue adds water and again decocts, merge twice and decoct gained filtrate, concentrated, dry, pulverize and make medicated powder;
(5) by made to step (2) (4) medicated powder mixing, with sucrose and dried starch mixing, add starch slurry soft material, granulate, dry, granulate, obtains granule.
Model case: xxx, man, 62 years old.Main suit: time have headache and dizzy, with weak, fat, think be sleep bad caused by, headache always continue about 1 year, to feel sick time serious nausea, lie awake all night, left limb self-induction is numb, examination in hospital, be diagnosed as the micro-adenocarcinoma of hypophysis cerebri, carry out excision, and in conjunction with Chinese traditional treatment.
Take the preparation granules agent of the present embodiment gained treatment brain cancer, adopt every day 2 times, each 4-7g, with warm boiled water, 21 days courses for the treatment of.After taking a course for the treatment of, headache alleviates, and sleep quality improves, and after taking two courses for the treatment of, checks and occurs without new focus, after taking four courses for the treatment of, patient mental is good, no headache, and appetite is good, and other indexs of health are all normal, physical recovery is good, and leave hospital, follow up a case by regular visits to after 1 year, patient body is in good condition.
embodiment 4the preparation of the treatment brain cancer, is prepared from (every part of 10g) primarily of following bulk drugs: Spica Prunellae 13 parts, Radix Fortunellae Margaritae 13 parts, Oletum Trogopterori 10 parts, oil head grass 13 parts, Carnis Pseudosciaenae 16 parts, Crepis crocea Babc.(C.turczaninowii C.A.Mey.) 14 parts, bracketplant 14 parts, Radix Cissi Kerrii 11 parts, Cycas revoluta Thunb. 11 parts, Herba Epilobii Himalayensis 12 parts, Semen Gleditsiae 10 parts, Rhizoma amorphophalli 11 parts, Herba Eragrostidis pilosae 14 parts, 15 parts, Tremella, Radix Ranunculi Ternati 11 parts, Radix et Rhizoma Dysosmatis 11 parts, sheep dung fruit 10 parts.
The preparation method of the preparation capsule of the treatment brain cancer is:
(1) Spica Prunellae and Rhizoma amorphophalli are cut into small pieces, reinstate saline with Semen Gleditsiae one and clean, add Radix Glycyrrhizae and mix thoroughly, to be placed in steamer Steam by water bath thoroughly after, take out, removing Radix Glycyrrhizae, dries;
(2) get Cycas revoluta Thunb. and sheep dung fruit clean, be cut into small pieces or mash, pulling out after flooding 20 minutes with sweet wine, Testa Tritici is sprinkled in frying pan and is heated to smolder, put into crude drug, constantly stir-fry to crude drug surface micro-Huang, take out, sieve remove Testa Tritici, dry;
(3) bracketplant, Radix et Rhizoma Dysosmatis and Radix Ranunculi Ternati roguing are cleaned, boil 15 minutes with rice-washed water big fire, take out, dry, then boil 10 minutes with vinegar, take out, dry;
(4) Radix Fortunellae Margaritae, Oletum Trogopterori, oil head grass, Carnis Pseudosciaenae, Crepis crocea Babc.(C.turczaninowii C.A.Mey.), Radix Cissi Kerrii, Herba Epilobii Himalayensis, Herba Eragrostidis pilosae and Tremella roguing are cleaned, decoct with water together with step (1) (3) made crude drug, amount of water is 8 times of boiled crude drug quality, turn little fire after big fire boils 10 minutes and decoct 27 minutes, filter, filtering residue adds water and again decocts, and merges twice and decocts gained filtrate, concentrated, dry;
(5) step (2) (4) made crude drug was pulverized 150 mesh sieves together with dry thing and make medicated powder, with sucrose and dried starch mixing, add starch slurry soft material, obtained granule, incapsulates, obtains capsule.
Model case: xxx, man, 60 years old.Occurred that recurrent dizziness was had a headache before 2 years, nausea and vomiting, general with carsickness, examination in hospital is diagnosed as the brain cancer, patient carries out excision later six months, again occur headache syndromes, and with limbs to a certain degree and aphasis, stride is crooked, slurred speech, pale white complexion, examination in hospital finds that there is new focus and generates, and household selects Chinese traditional treatment.
Take the preparation capsule of the present embodiment gained treatment brain cancer, adopt every day 2 times, each 3-4 grain, with warm water delivery service, 21 days courses for the treatment of.After taking a course for the treatment of, headache alleviates, and appetite increases, complexion takes a turn for the better, limb activity ability improves, and after taking three courses for the treatment of, patient's malaise symptoms is eliminated substantially, the mental status is good, focus obviously reduces, and after taking five courses for the treatment of, patient is without malaise symptoms, life can be taken care of oneself, after still to take medicine consolidate curative effect.
embodiment 5the preparation of the treatment brain cancer, is prepared from (every part of 10g) primarily of following bulk drugs: Spica Prunellae 11.5 parts, Radix Fortunellae Margaritae 11 parts, Oletum Trogopterori 9 parts, oil head grass 11.5 parts, Carnis Pseudosciaenae 15 parts, Crepis crocea Babc.(C.turczaninowii C.A.Mey.) 13 parts, bracketplant 12 parts, Radix Cissi Kerrii 10 parts, Cycas revoluta Thunb. 10 parts, Herba Epilobii Himalayensis 11 parts, Semen Gleditsiae 9.5 parts, Rhizoma amorphophalli 9.5 parts, Herba Eragrostidis pilosae 12.5 parts, 13.5 parts, Tremella, Radix Ranunculi Ternati 10.5 parts, Radix et Rhizoma Dysosmatis 10.5 parts, sheep dung fruit 9 parts.
The preparation method of the preparation decoction of the treatment brain cancer is:
(1) Spica Prunellae and Rhizoma amorphophalli are cut into small pieces, reinstate saline with Semen Gleditsiae one and clean, add Radix Glycyrrhizae and mix thoroughly, to be placed in steamer Steam by water bath thoroughly after, take out, removing Radix Glycyrrhizae, dries;
(2) get Cycas revoluta Thunb. and sheep dung fruit clean, be cut into small pieces, pull out after flooding 20 minutes with sweet wine, Testa Tritici is sprinkled in frying pan and is heated to smolder, put into crude drug, constantly stir-fry to crude drug surface micro-Huang, take out, sieve remove Testa Tritici, dry;
(3) bracketplant, Radix et Rhizoma Dysosmatis and Radix Ranunculi Ternati roguing are cleaned, boil 15 minutes with rice-washed water big fire, take out, dry, then boil 10 minutes with vinegar, take out, dry;
(4) Radix Fortunellae Margaritae, Oletum Trogopterori, oil head grass, Carnis Pseudosciaenae, Crepis crocea Babc.(C.turczaninowii C.A.Mey.), Radix Cissi Kerrii, Herba Epilobii Himalayensis, Herba Eragrostidis pilosae and Tremella roguing are cleaned, decoct with water together with step (1) (2) (3) made crude drug, amount of water is 6 times of boiled crude drug quality, turn little fire after big fire boils 10 minutes and decoct 27 minutes, filter, collect filtrate, obtain decoction.
test example 1the clinical practice of the preparation (embodiment 5) of the gained treatment brain cancer of the present invention:
Clinical data: in October, 2011 in December ,-2014, in 6 tumour hospital screen 228 routine brain cancer patients, wherein women 102 example, male 126 example, age 54-72 year, the mean age (62.4 ± 4.5) year, the course of disease 3 months-2 years, constitutional 85 example, Secondary cases 143 example.Clinical symptoms has headache, Nausea and vomiting, physical handicaps, disturbance of consciousness, epilepsy, vision change, facial paralysis, psychological problem aphasia, ataxia.All treatment is not affected through routine blood test, hepatic and renal function, Electrocardioscopy before treatment.
Patient is divided into two groups at random, experimental group 128 example and matched group 100 routine, two groups in sex, age, the course of disease, the state of an illness etc. without significant difference (
p> 0.05), there is comparability.Matched group adopts conventional chemicotherapy scheme, experimental group takes products obtained therefrom of the present invention on the basis of matched group, take every day twice (warm), each 350m1-500m1(adjusts to some extent depending on concrete condition), 21 days courses for the treatment of, three courses for the treatment of of continuous treatment, treatments period carries out Continuous Observation to two groups of patients, record symptom and change.
Curative effect situation criterion: complete incidence graph (CR): focus disappears completely, and maintain more than 4 weeks; Partial rcsponse (DR): focus reduces more than 50%, maintains more than 4 weeks; Stable (NC): focus reduces and do not reach 25%, without newborn focus less than 50% or increase; Worsen (PD): focus increases more than 25% or have new focus to occur.Total effective rate=complete remission rate+partial rcsponse rate
Therapeutic outcome: in experimental group patient, focus complete incidence graph patient 43 example (33.6%), partial rcsponse patient 68 example (53.1%), focus stablizes patient 15 example (11.7%), and focus worsens patient 2 example (1.6%), and experimental group total effective rate is 86.7%.In matched group patient, complete incidence graph 23 example (23.0%), partial rcsponse 44 example (44.0%), stablizes 20 examples (20.0%), worsens 13 examples (13.0%), and matched group total effective rate is 67.0%.Compare known for two groups, total effective rate has significant difference (P < 0.05).Follow up a case by regular visits to 2 years after treatment, it is that after 86.7%, 1 year, survival rate is 60.2% that experimental group treats survival rate after 6 months, and treating survival rate after 2 years is 38.3%.
The Spica Prunellae of liver heat removing eliminating stagnation is had in formula of the present invention, the Radix Fortunellae Margaritae of promoting QI to circulate and dispersing the agglomeration of the pathogens, the Oletum Trogopterori of promoting the circulation of blood pain relieving, the oil head grass of heat-clearing and toxic substances removing, the Carnis Pseudosciaenae of replenishing QI to invigorate the spleen, the Crepis crocea Babc.(C.turczaninowii C.A.Mey.) of liver and kidney tonifying, the bracketplant of preventing phlegm from forming and stopping coughing, the Radix Cissi Kerrii of heat-clearing and toxic substances removing, the Cycas revoluta Thunb. of invigorating the spleen and regulating the stomach, the Herba Epilobii Himalayensis of wind and heat dispersing, dispel the wind the Semen Gleditsiae of subsiding a swelling, the Rhizoma amorphophalli of dispersing swelling and dissipating binds, the Herba Eragrostidis pilosae of inducing diuresis for treating stranguria syndrome, the Tremella of nourishing YIN to relieve dryness, the Radix Ranunculi Ternati of detoxicating and resolving stagnation of pathogens, the Radix et Rhizoma Dysosmatis of dissipating phlegm and resolving masses, promote the production of body fluid astringing intestine to stop diarrhea sheep dung fruit, all medicines share, resolving mass and removing the obstruction of the collateral can be played, the effects such as eliminating toxic substances to remove stasis.
It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or according to undoubted the obtaining of the written description of file, the claimed scope of this patent all should be thought.
Claims (10)
1. treat the preparation of the brain cancer, it is characterized in that, be prepared from primarily of following bulk drugs, be mass parts: Spica Prunellae 9-14, Radix Fortunellae Margaritae 7-15, Oletum Trogopterori 6-12, oil head grass 8-15, Carnis Pseudosciaenae 12-18, Crepis crocea Babc.(C.turczaninowii C.A.Mey.) 10-16, bracketplant 9-15, Radix Cissi Kerrii 7-13, Cycas revoluta Thunb. 8-12, Herba Epilobii Himalayensis 9-13, Semen Gleditsiae 7-12, Rhizoma amorphophalli 6-13, Herba Eragrostidis pilosae 9-16, Tremella 10-17, Radix Ranunculi Ternati 8-13, Radix et Rhizoma Dysosmatis 9-12, sheep dung fruit 7-11.
2. the preparation of the treatment brain cancer as claimed in claim 1, it is characterized in that, Spica Prunellae 10-13, Radix Fortunellae Margaritae 9-13, Oletum Trogopterori 8-10, oil head grass 10-13, Carnis Pseudosciaenae 14-16, Crepis crocea Babc.(C.turczaninowii C.A.Mey.) 12-14, bracketplant 10-14, Radix Cissi Kerrii 9-11, Cycas revoluta Thunb. 9-11, Herba Epilobii Himalayensis 10-12, Semen Gleditsiae 9-10, Rhizoma amorphophalli 8-11, Herba Eragrostidis pilosae 11-14, Tremella 12-15, Radix Ranunculi Ternati 10-11, Radix et Rhizoma Dysosmatis 10-11, 8-10 is (preferred for sheep dung fruit, Spica Prunellae 11.5, Radix Fortunellae Margaritae 11, Oletum Trogopterori 9, oil head grass 11.5, Carnis Pseudosciaenae 15, Crepis crocea Babc.(C.turczaninowii C.A.Mey.) 13, bracketplant 12, Radix Cissi Kerrii 10, Cycas revoluta Thunb. 10, Herba Epilobii Himalayensis 11, Semen Gleditsiae 9.5, Rhizoma amorphophalli 9.5, Herba Eragrostidis pilosae 12.5, Tremella 13.5, Radix Ranunculi Ternati 10.5, Radix et Rhizoma Dysosmatis 10.5, sheep dung fruit 9).
3. the preparation of the treatment brain cancer as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable decoction, its preparation method is:
(1) Spica Prunellae and Rhizoma amorphophalli are cut into small pieces, reinstate saline with Semen Gleditsiae one and clean, add Radix Glycyrrhizae and mix thoroughly, to be placed in steamer Steam by water bath thoroughly after, take out, removing Radix Glycyrrhizae, dries;
(2) get Cycas revoluta Thunb. and sheep dung fruit clean, be cut into small pieces, pull out after flooding 20 minutes with sweet wine, Testa Tritici is sprinkled in frying pan and is heated to smolder, put into crude drug, constantly stir-fry to crude drug surface micro-Huang, take out, sieve remove Testa Tritici, dry;
(3) bracketplant, Radix et Rhizoma Dysosmatis and Radix Ranunculi Ternati roguing are cleaned, boil 15 minutes with rice-washed water big fire, take out, dry, then boil 10 minutes with vinegar, take out, dry;
(4) Radix Fortunellae Margaritae, Oletum Trogopterori, oil head grass, Carnis Pseudosciaenae, Crepis crocea Babc.(C.turczaninowii C.A.Mey.), Radix Cissi Kerrii, Herba Epilobii Himalayensis, Herba Eragrostidis pilosae and Tremella roguing are cleaned, decoct with water together with step (1) (2) (3) made crude drug, turn a little fire after big fire boils 10 minutes to decoct 20-35 minute (preferred, 25-30 minute decocted by little fire; Be more preferably, little fire decocts 27 minutes), filter, collect filtrate, obtain decoction.
4. the preparation method of the preparation decoction of the treatment brain cancer as claimed in claim 3, is characterized in that, the 5-7 that step (4) amount of water is boiled crude drug quality is (preferred, amount of water is 6 times of boiled crude drug quality) doubly.
5. the preparation of the treatment brain cancer as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable powder, its preparation method is:
(1) Spica Prunellae and Rhizoma amorphophalli are cut into small pieces, reinstate saline with Semen Gleditsiae one and clean, add Radix Glycyrrhizae and mix thoroughly, to be placed in steamer Steam by water bath thoroughly after, take out, removing Radix Glycyrrhizae, dries;
(2) get Cycas revoluta Thunb. and sheep dung fruit clean, be cut into small pieces, pull out after flooding 20 minutes with sweet wine, Testa Tritici is sprinkled in frying pan and is heated to smolder, put into crude drug, constantly stir-fry to crude drug surface micro-Huang, take out, sieve remove Testa Tritici, dry, pulverize make medicated powder;
(3) bracketplant, Radix et Rhizoma Dysosmatis and Radix Ranunculi Ternati roguing are cleaned, boil 15 minutes with rice-washed water big fire, take out, dry, then boil 10 minutes with vinegar, take out, dry;
(4) Radix Fortunellae Margaritae, Oletum Trogopterori, oil head grass, Carnis Pseudosciaenae, Crepis crocea Babc.(C.turczaninowii C.A.Mey.), Radix Cissi Kerrii, Herba Epilobii Himalayensis, Herba Eragrostidis pilosae and Tremella roguing are cleaned, decoct with water together with step (1) (3) made crude drug, amount of water is 8 times of boiled crude drug quality, turn a little fire after big fire boils 10 minutes to decoct 20-35 minute (preferred, 25-30 minute decocted by little fire; Be more preferably, little fire decocts 27 minutes), filter, filtering residue adds water and again decocts, and merges twice and decocts gained filtrate, concentrated, dry, pulverize and makes medicated powder, mix, obtain powder with step (2) made medicated powder.
6. the preparation method of the preparation powder of the treatment brain cancer as claimed in claim 5, is characterized in that, step (4) pulverized 100-140 mesh sieve (preferred, to pulverize 120 mesh sieves).
7. the preparation of the treatment brain cancer as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable granule, its preparation method is:
(1) Spica Prunellae and Rhizoma amorphophalli are cut into small pieces, reinstate saline with Semen Gleditsiae one and clean, add Radix Glycyrrhizae and mix thoroughly, to be placed in steamer Steam by water bath thoroughly after, take out, removing Radix Glycyrrhizae, dries;
(2) get Cycas revoluta Thunb. and sheep dung fruit clean, be cut into small pieces, pull out after flooding 20 minutes with sweet wine, Testa Tritici is sprinkled in frying pan and is heated to smolder, put into crude drug, constantly stir-fry to crude drug surface micro-Huang, take out, sieve remove Testa Tritici, dry, pulverize make medicated powder;
(3) bracketplant, Radix et Rhizoma Dysosmatis and Radix Ranunculi Ternati roguing are cleaned, boil 15 minutes with rice-washed water big fire, take out, dry, then boil 10 minutes with vinegar, take out, dry;
(4) Radix Fortunellae Margaritae, Oletum Trogopterori, oil head grass, Carnis Pseudosciaenae, Crepis crocea Babc.(C.turczaninowii C.A.Mey.), Radix Cissi Kerrii, Herba Epilobii Himalayensis, Herba Eragrostidis pilosae and Tremella roguing are cleaned, decoct with water together with step (1) (3) made crude drug, amount of water is 8 times of boiled crude drug quality, turn little fire after big fire boils 10 minutes to decoct, filter, filtering residue adds water and again decocts, merge twice and decoct gained filtrate, concentrated, dry, pulverize and make medicated powder;
(5) by made to step (2) (4) medicated powder mixing, with sucrose and dried starch mixing, add starch slurry soft material, granulate, dry, granulate, obtains granule.
8. the preparation method of the preparation granules agent of the treatment brain cancer as claimed in claim 7, is characterized in that, turns a little fire and decoct 20-35 minute (preferred, 25-30 minute decocted by little fire after step (4) big fire boils 10 minutes; Be more preferably, little fire decocts 27 minutes).
9. the preparation of the treatment brain cancer as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable capsule, its preparation method is:
(1) Spica Prunellae and Rhizoma amorphophalli are cut into small pieces, reinstate saline with Semen Gleditsiae one and clean, add Radix Glycyrrhizae and mix thoroughly, to be placed in steamer Steam by water bath thoroughly after, take out, removing Radix Glycyrrhizae, dries;
(2) get Cycas revoluta Thunb. and sheep dung fruit clean, be cut into small pieces or mash, pulling out after flooding 20 minutes with sweet wine, Testa Tritici is sprinkled in frying pan and is heated to smolder, put into crude drug, constantly stir-fry to crude drug surface micro-Huang, take out, sieve remove Testa Tritici, dry;
(3) bracketplant, Radix et Rhizoma Dysosmatis and Radix Ranunculi Ternati roguing are cleaned, boil 15 minutes with rice-washed water big fire, take out, dry, then boil 10 minutes with vinegar, take out, dry;
(4) Radix Fortunellae Margaritae, Oletum Trogopterori, oil head grass, Carnis Pseudosciaenae, Crepis crocea Babc.(C.turczaninowii C.A.Mey.), Radix Cissi Kerrii, Herba Epilobii Himalayensis, Herba Eragrostidis pilosae and Tremella roguing are cleaned, decoct with water together with step (1) (3) made crude drug, amount of water is 8 times of boiled crude drug quality, turn a little fire after big fire boils 10 minutes to decoct 20-35 minute (preferred, 25-30 minute decocted by little fire; Be more preferably, little fire decocts 27 minutes), filter, filtering residue adds water and again decocts, and merges twice and decocts gained filtrate, concentrated, dry;
(5) step (2) (4) made crude drug is pulverized together with dry thing make medicated powder, with sucrose and dried starch mixing, add starch slurry soft material, obtain granule, incapsulate, obtain capsule.
10. the preparation method of the preparation capsule of the treatment brain cancer as claimed in claim 9, it is characterized in that, step (5) was pulverized 100-200 mesh sieve and (preferably, was pulverized 130-170 mesh sieve; Be more preferably, pulverized 150 mesh sieves).
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| CN1943778A (en) * | 2006-10-25 | 2007-04-11 | 薛忠 | The mixture of cobra venom and Chinese medical herb extract and its application |
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