CN106177590A - A kind of Chinese medicinal capsule for treating infantile spasm tourette syndrome - Google Patents

A kind of Chinese medicinal capsule for treating infantile spasm tourette syndrome Download PDF

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CN106177590A
CN106177590A CN201610780199.3A CN201610780199A CN106177590A CN 106177590 A CN106177590 A CN 106177590A CN 201610780199 A CN201610780199 A CN 201610780199A CN 106177590 A CN106177590 A CN 106177590A
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parts
grams
herba
tourette syndrome
rhizoma
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卞永兴
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/57—Birds; Materials from birds, e.g. eggs, feathers, egg white, egg yolk or endothelium corneum gigeriae galli
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/63—Arthropods
    • A61K35/646—Arachnids, e.g. spiders, scorpions, ticks or mites
    • A—HUMAN NECESSITIES
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    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/076—Poria
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/282—Artemisia, e.g. wormwood or sagebrush
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284—Atractylodes
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    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
    • A61K36/725—Ziziphus, e.g. jujube
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
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    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8962—Allium, e.g. garden onion, leek, garlic or chives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4875—Compounds of unknown constitution, e.g. material from plants or animals

Abstract

The invention discloses a kind of Chinese medicinal capsule for treating infantile spasm tourette syndrome, the Chinese crude drug of following weight proportion be prepared from: Europe Herba melissae axillaris 16 parts, Herba Triglochinis 10 parts, white wolf Herba Alii fistulosi 9 parts, 8 parts of Poria, the Rhizoma Atractylodis Macrocephalae 7 parts, Corvus macrorhuchus liver 11 parts, Herba Artemisiae Annuae 8 parts, Concretio Silicea Bambusae 10 parts, Folium cordylines fruticosae 9 parts, Scorpio 6 parts, Rhizoma Acori Graminei 5 parts, pittosporm root 7 parts, Rhizoma Arisaematis 14 parts, Herba Murdanniae Divergentis 12 parts, Flos Rosae Rugosae 11 parts, Radix Rhapontici 8 parts, Semen Ziziphi Spinosae 6 parts, Flos Albiziae 6 parts, Liquor Fructus Citri sarcodactylis Distillata 15 parts, Endocarpium Citri tangerinae 6 parts.Clinical trial certificate, the present invention reasonable compatibility by Chinese crude drug, contribute to treating infantile spasm tourette syndrome, rapid-action, determined curative effect, reach integrally-regulated and long-term effect good effects.

Description

A kind of Chinese medicinal capsule for treating infantile spasm tourette syndrome
Technical field
The present invention relates to a kind of Chinese medicinal capsule, be specifically related to a kind of Chinese medicine glue for treating infantile spasm tourette syndrome Capsule.
Background technology
Coprolalia syndrome, is a kind of complexity, chronic forms mental disorder, and onset is in the Childhood, with many Plant motion and sounding twitch is mainly performance, be often accompanied by behavior and dysthymic disorders such as forcing, the most dynamic.Main clinical manifestation is frequent Nictation, squeezing eyebrow, shake the head, shrug, turn round neck, the abnormal sound the most independently sent in larynx, minority infant has that loses control of to swear at people, says Dirty word.The cause of disease of coprolalia syndrome not completely determines, conventional Chinese traditional treatment only relies on several taste medicine and is difficult to look after comprehensively, Multi-medicament suitably must be coordinated, improve curative effect or reduce untoward reaction, to adapt to the treatment of the complicated state of an illness.In view of various Chinese medicines The interaction in vivo of the various active composition of material is sufficiently complex, various medicines pharmacokinetics in vivo and pharmacodynamics etc. The change of aspect can produce various impacts to the interaction between medicine, during drug combination, both may produce Synergistic Drug effect, it is also possible to producing antagonism, and then cause Drug therapy declines or Endodontic failure, some drug combination also can make Obtain drug toxicity to strengthen, cause untoward reaction；Even if drug combination makes effect strengthen, but the meeting when therapeutical effect excessively strengthens Beyond the tolerant ability of body, it is possible to cause untoward reaction, or even harm patient.Part research toward from intend Chinese medicinal formulae with Phase treatment infantile spasm tourette syndrome, the most easily problem appear to is that the compatibility of medicines in a prescription is unreasonable, may often be such that only single from some Taste or polypharmaceutic discrete function cure mainly and remove to copy mechanically and apply indiscriminately Chinese medical theory with some pharmacodynamic index, and prescription flavour of a drug arbitrarily add Subtract, cause prescription unreasonable, contradict with Chinese medical theory.
Summary of the invention
It is desirable to provide a kind of Chinese medicinal capsule for treating infantile spasm tourette syndrome, by the conjunction of Chinese crude drug Reason compatibility, contributes to treating infantile spasm tourette syndrome, and can effectively reduce complication, reach integrally-regulated and long-term effect Good effects.
In order to achieve the above object, the present invention is by the following technical solutions: a kind of for treating infantile spasm tourette syndrome Chinese medicinal capsule, is prepared from by the Chinese crude drug of following weight proportion: Europe Herba melissae axillaris 16 parts, Herba Triglochinis 10 parts, white wolf Herba Alii fistulosi 9 parts, Fu Siberian cocklebur 8 parts, the Rhizoma Atractylodis Macrocephalae 7 parts, Corvus macrorhuchus liver 11 parts, Herba Artemisiae Annuae 8 parts, Concretio Silicea Bambusae 10 parts, Folium cordylines fruticosae 9 parts, Scorpio 6 parts, Rhizoma Acori Graminei 5 parts, Fructus Gardeniae Tea 7 parts, Rhizoma Arisaematis 14 parts, Herba Murdanniae Divergentis 12 parts, Flos Rosae Rugosae 11 parts, Radix Rhapontici 8 parts, Semen Ziziphi Spinosae 6 parts, Flos Albiziae 6 parts, Liquor Fructus Citri sarcodactylis Distillata 15 Part, Endocarpium Citri tangerinae 6 parts.
Preparation method is: go above-mentioned medical material in addition to Liquor Fructus Citri sarcodactylis Distillata respectively to mix after the removal of impurity, send in drying baker in Dry at a temperature of 120 DEG C, be ground into 100-130 mesh smalls, then mix homogeneously with Liquor Fructus Citri sarcodactylis Distillata, after disinfection by ultraviolet light, press 0.5g/ Grain loads capsule, is finished product.
The pharmacology analysis of each Chinese medicinal ingredients of the present invention is as follows:
Europe Herba melissae axillaris [source] is the herb of labiate Europe Herba melissae axillaris.[nature and flavor] two grades are xeothermic, and taste is micro-pungent.[function master Control] raw dry heat, temperature compensation heart, dispersing cold for relieving pain, relieving restlessness calms the nerves, clean blood blood pressure lowering, dampness nourishing muscle and tendon, and cold relieving is relievingd asthma, eliminating inflammation and expelling toxin.
Herba Triglochinis [source] Juncaginaceae Triglochin plant Herba Triglochinis, with all herbal medicine.[nature and flavor] are sweet, flat.[function Cure mainly] clearing away heat and nourishing YIN, promoting the production of body fluid to quench thirst.For deficiency of YIN hectic fever, gastric heat excessive thirst, dry mouth and tougue.
White wolf Herba Alii fistulosi [source] Liliaceae indigo plant Jacob's ladder, with all herbal medicine.[nature and flavor] are pungent, temperature.[function cures mainly] dissipates wind Cold, activate yang, stomach invigorating.Curing mainly wind and cold diseases caused by exogenous pathogenic factor, YIN-cold is suffered from abdominal pain, cold extremities faint pulse, traumatic injury.
The dry lobule of Cassia siamea leaf [source] leguminosae cassia plant Cassia siamea.[nature and flavor] bitter in the mouth, cold in nature, enter water, wind Tower.[function cures mainly] expelling wind and removing dampness, reducing swelling and alleviating pain, killing parasites for relieving itching.
The dry leaves of Folium Alstoniae Scholaris [source] Apocynaceae Alstonia plant sugar gum.[nature and flavor] bitter in the mouth, micro-puckery, Cold.[function cures mainly] Qinghuo Jiedu, reducing swelling and alleviating pain, relieving cough and resolving phlegm.
Herba Gonostegiae hirtae [source] is the whole herb with root of contrayerva Herba Gonostegiae Hirtae.[nature and flavor] sweetness and bitterness, cool.[function cures mainly] heat clearing away Removing toxic substances, spleen invigorating, hemostasis.Treatment skin ulcer, carbuncle, scrofula, dysentery, women leucorrhea, infantile malnutrition, spit blood, traumatic hemorrhage.
Poria [source] this product is the dry sclerotia of On Polyporaceae Poria.[nature and flavor] are sweet, light, flat.[return through] returns The heart, lung, spleen, kidney channel.[function cures mainly] promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming.For edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, just Diarrhea with loose stool is rushed down, irritability, palpitation with fear insomnia.
The Rhizoma Atractylodis Macrocephalae [source] this product is the dry rhizome of the feverfew Rhizoma Atractylodis Macrocephalae.[nature and flavor] are bitter, sweet, temperature.[return through] return spleen, Stomach warp.[function cures mainly] invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive.For insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, water Swollen, spontaneous perspiration, frequent fetal movement.Rhizoma Atractylodis Macrocephalae spleen invigorating, stomach function regulating, antiabortive.For insufficiency of the spleen lack of appetite, loose stool of having loose bowels, frequent fetal movement.
Corvus macrorhuchus liver [source] is the liver of Corvidae animal C.macrorhynchus.[nature and flavor] sour in the mouth, puckery, property is cold.[function cures mainly] dispels Wind determines epilepsy.Cure mainly phlegm-accumulating vertigo, epilepsy.
Herba Artemisiae Annuae [source] this product is the dry aerial parts of feverfew Herba Artemisiae annuae.[nature and flavor] bitter, acrid, cold.[return through] Return liver, gallbladder meridian.[function cures mainly] clearing away summer-heat, except steaming, preventing the attack (or recurrence) of malaria.Generate heat for pathogenic summer-heat, fever due to yin deficiency, night fever abating at dawn, hectic fever due to YIN-deficiency labor Heat, malaria cold and heat, jaundice due to damp-heat.
Concretio Silicea Bambusae [source] is the bleeding sap stored up between the rings such as grass Chinese textile bamboo, Bao Zhu, through dry condensation The cake mass become.[nature and flavor] are sweet；Cold.[return through] heart；Liver；Gallbladder meridian.[function cures mainly] removing heat-phlegm；The cool heart is calmed the frightened.Main little Youngster's infantile convulsion；Epilepsy；Middle wind-phlegm fan；Calentura coma；Expectorant heat syndrome cough is breathed heavily.
Folium cordylines fruticosae [source] is the leaf of Agavaceae plant ti.[nature and flavor] are sweet light, cool.[function cures mainly] heat clearing away, hemostasis, Dissipating blood stasis.Control dysentery, spit blood, have blood in stool, stomachache, hematuria, menorrhagia, treating swelling and pain by traumatic injury.
Scorpio [source] this product is the dry body of Buthidae animal Scorpio.[nature and flavor] are pungent, flat；Poisonous.[return through] Return Liver Channel.[function cures mainly] endogenous wind stopping spasmolytic, dispersing pathogen accumulation, removing obstruction in the collateral to relieve pain.For infantile convulsion, tic spasm, middle air port is askew, Hemiplegia, tetanus, rheumatoid arthritis stubborn, migraine and general headache, skin infection, scrofula.
The rhizome of Rhizoma Acori Graminei [source] acorus gramineus araceae plant.[function cures mainly] removing dampness is whetted the appetite, eliminating phlegm of having one's ideas straightened out, refreshment Fructus Alpiniae Oxyphyllae.The most hungry for gastral cavity painful abdominal mass, a mouthful dysentery of keeping silent, coma epilepsy, forgetful deafness.Regulate the flow of vital energy, invigorate blood circulation, dissipate wind, dry.Control epilepsy, syncope due to accumulation of phlegm, Calentura coma, forgetful, deafness with qi stagnation, ambition is unhappy, stomachache, stomachache, anemofrigid-damp arthralgia, swollen ulcer drug, traumatic injury.
Pittosporm root [source] is the root of Pittosporaceae plant sea gold, root bark.[nature and flavor] bitter in the mouth, peppery, property is cold.[function master Control] calm.Calm the nerves, qi-restoratives, blood pressure lowering.Cure mainly neurasthenia.Insomnia and dreamful sleep, the seminal emission of body void, hypertension.
Rhizoma Arisaematis [source] medical material Ji Yuan: for the plant of Bryaceae plant warm ground great Ye moss.[nature and flavor] are pungent；Bitter；Flat. [function cures mainly] tranquilizing by nourishing the heart；Liver heat removing and eyesight improving.Main severe palpitation；Neurasthenia；Conjunctival congestion and swelling pain；Coronary heart disease；Hypertension etc..
Herba Murdanniae Divergentis [source] medical material Ji Yuan: for root or the Herb of Commelianaceae plant purple back of the body Herba Pyrolae.[nature and flavor] are sweet；Micro- Bitter；Flat.[function cures mainly] clearing away lung-heat to relieve cough；Invigorating the lung and the kidney；Regulating menstruation, hemostasis.Main cough due to lung-heat；The deficiency of vital energy is breathed with cough；Dizziness and tinnitus；Fracture； Spit blood.
Flos Rosae Rugosae [source] this product is the dry flower of rosaceous plant Flos Rosae Rugosae.[nature and flavor] hardship sweet, micro-, temperature.[return through] returns Liver, spleen channel.[function cures mainly] promoting QI circulation for relieving depression, and blood, pain relieving.For stomachache due to hyperactive liver-QI attacking the stomach, lack of appetite vomiting and nausea, menoxenia, fall and flutter the pain of injury.
Radix Rhapontici [source] is the root of feverfew centaurea monanthos Georgi or Radix Echinopsis.[nature and flavor] bitter in the mouth；Cold in nature.[return through] returns Stomach；Large intestine；Liver Channel.[function cures mainly] heat-clearing and toxic substances removing；Invigorate blood circulation lactogenesis.Cure mainly furuncle toxic swelling；Acute mastitis；Rib adenitis；Drench horse knot tuberculosis； Hemorrhoid complicated by anal fistula；Scabies prurigo；Conjunctival congestion and swelling pain；Dysentery；Ascarid early stomachache；Rheumatic arthralgia；Lumbar sprain and QI divergeny；Traumatic injury；Lack of lactation after delivery.
Semen Ziziphi Spinosae [source] this product is the dry mature seed of Rhamnaceae plant Ziziphi Spinosae.[nature and flavor] are sweet, sour, flat.[return Warp] return liver, gallbladder, heart channel.[function cures mainly] tonifying liver, mind calming, arresting sweating, promotes the production of body fluid.For restlessness of asrhenia type and insomnia, dreaminess of palpitating with fear, body void is many Antiperspirant, Tianjin wound is thirsty.
Flos Albiziae [source] this product is the dry inflorescence of leguminous plant Herba Albiziae.[nature and flavor] are sweet, flat.[return through] GUIXIN, liver Warp.[function cures mainly] resolving stagnation for tranquilization.For irritability, melancholy insomnia.
Liquor Fructus Citri sarcodactylis Distillata [source] medical material Ji Yuan: for the distillate of the fruit of rutaceae Fructus Citri Sarcodactylis.[nature and flavor] are micro-pungent；Light；Property Flat.[return through] lung；Liver；Stomach；Kidney channel.[function cures mainly] promoting QI circulation for relieving depression.Main chest and diaphragm is gloomy not to relax.
Endocarpium Citri tangerinae [source] medical material Ji Yuan: for rutaceae orange and the white internal layer peel of variety thereof.[nature and flavor] are bitter； Pungent；Micro-sweet；Temperature.[return through] stomach warp.[function cures mainly] stomach function regulating removing dampness.Main turbid damp internal resistance；Feeling of oppression and fullness in the chest and epigastrium；Inappetence.
Herba leucadis zeylanicae [source] is labiate crape face grass and the herb of honeybee fruit grass.[nature and flavor] acrid in the mouth；Bitter；Property flat.[function Cure mainly] removing toxic substances；Cough-relieving；Improving eyesight；Stimulate the menstrual flow.Cure mainly flu；Headache；Asthma；Pertussis；Laryngopharynx swelling and pain；Toothache；Dyspepsia；Month Through uncomfortable；Amenorrhea；Extort under false pretense blind；Cellular furuncle.
Brocade is by flower [source] medical material Ji Yuan: for herb or flower, the fruit of bloodroot Flos Papaveris rhoeadis.[nature and flavor] are bitter；Puckery； It is slightly cold；Poisonous.[return through] large intestine channel.[function cures mainly] antitussive；Analgesia；Antidiarrheal.Main cough；Migraine；Stomachache；Dysentery.
The present invention compared with prior art, has the advantages that
1, the selected medicament composing prescription of the present invention, its drug component through dialectical compatibility, complements each other using, has synergism, Treatment to infantile spasm tourette syndrome reaches treating both the principal and the secondary aspects of a disease at the same time.Inventor, according to clinical experience for many years, sums up child and takes out The cause of disease of dynamic tourette syndrome is mainly liver-wind stirring up internally, malaise, and sick position is mainly liver, relevant to the heart, spleen, lung, kidney.This Bright prescription is particular about monarch, four natures and five flavors of drug lifting, and the 8 taste medical materials such as Europe Herba melissae axillaris, Rhizoma Arisaematis, Herba Murdanniae Divergentis are monarch drug altogether, Compound recipe plays a leading role, treats disease by acting on major target class；7 tastes such as Radix Rhapontici, Herba Artemisiae Annuae, Endocarpium Citri tangerinae are ministerial drug altogether, Strengthen the pharmacological action of monarch drug by acting on the target spot identical with monarch drug, thus reduce monarch drug required dosage；Remaining for assistant, Make medical herbs, to improve the bioavailability of monarch, ministerial drug, coordinate the activity of their each composition.The present invention reuse Europe Herba melissae axillaris, one Umbrella is calmed the frightened with liver heat removing, and Herba Murdanniae Divergentis adjusts lung, and Scorpio, Corvus macrorhuchus liver are with suppressing the hyperactive liver to relieve the wind syndrome, Liquor Fructus Citri sarcodactylis Distillata, Flos Rosae Rugosae promoting QI circulation for relieving depression, Semen Ziziphi Spinosae, conjunction Joyous flower tranquilizing by nourishing the heart, Rhizoma Acori Graminei, Folium Alstoniae Scholaris reduce phlegm Fructus Alpiniae Oxyphyllae, then work in coordination with mutually with Herba Triglochinis, Radix Rhapontici, Herba Artemisiae Annuae, Endocarpium Citri tangerinae, white wolf Herba Alii fistulosi etc., All medicine complementation potentiation, preferably plays effect speciality, to infantile spasm tourette syndrome from Mutiple Targets, too many levels, multipath exhibition Open treatment, be finally reached the good efficacy for the treatment of infantile spasm tourette syndrome.Especially it is noted that the present inventor is through anti- Retrial is tested, and combines pharmacological research observation confirmation, unexpected product after the Corvus macrorhuchus liver phase 5 that the white wolf Herba Alii fistulosi of property and flavor of peppery and warm is cold with nature and flavor acid The raw unique curative effect strengthening infant brain activity and then alleviating infant disease.It is originally intended to Herba Triglochinis and the heat-clearing and toxic substances removing of promoting the production of body fluid to quench thirst Radix Rhapontici share, the merit that multiplication relaxing muscles and tendons is promoted blood circulation, and tic of the limbs when can effectively treat infant morbidity heightens the effect of a treatment.
2, the present invention is directed to infantile spasm tourette syndrome pathogeny, launch to control from Mutiple Targets, too many levels, multipath Treat, have in clinical practice rapid-action, determined curative effect, patient compliance are good, safe without toxic side effect, can significantly improve patient Autoimmunity, treating both the principal and secondary aspects of a disease prevents recurrence, thus has wide potential applicability in clinical practice.
Detailed description of the invention
In order to be more fully understood that and implement the present invention, further illustrate the present invention below in conjunction with specific embodiment.
Embodiment 1
Weigh: Europe Herba melissae axillaris 16 grams, Herba Triglochinis 10 grams, white wolf Herba Alii fistulosi 9 grams, 8 grams of Poria, the Rhizoma Atractylodis Macrocephalae 7 grams, Corvus macrorhuchus liver 11 grams, Herba Artemisiae Annuae 8 Gram, Concretio Silicea Bambusae 10 grams, Folium cordylines fruticosae 9 grams, Scorpio 6 grams, Rhizoma Acori Graminei 5 grams, pittosporm root 7 grams, Rhizoma Arisaematis 14 grams, Herba Murdanniae Divergentis 12 grams, rose Rare spend 11 grams, Radix Rhapontici 8 grams, Semen Ziziphi Spinosae 6 grams, Flos Albiziae 6 grams, Liquor Fructus Citri sarcodactylis Distillata 15 grams, Endocarpium Citri tangerinae 6 grams.
Mix after above-mentioned medical material in addition to Liquor Fructus Citri sarcodactylis Distillata is gone respectively the removal of impurity, send into drying baker interior at a temperature of 120 DEG C Dry, be ground into 100-130 mesh smalls, then mix homogeneously with Liquor Fructus Citri sarcodactylis Distillata, after disinfection by ultraviolet light, press 0.5g/ grain load capsule, It is finished product.
Usage and dosage: oral, every day 2 times, the most each 1 time, each 1, warm water delivery service after meal；Within 15 days, it is 1 course for the treatment of, Take 2 courses for the treatment of continuously.
Clinical data:
1, case selection:
Selecting the infantile spasm tourette syndrome patient 40 example clinical observation in my institute's diagnosis and treatment, clinical symptoms all meets infantile spasm Tourette syndrome diagnosis and treatment standard.Patient is randomly divided into treatment group and matched group two groups, treatment group 20 example, matched group 20 example.Treatment Group and the course of disease of two groups of cases of matched group, degrees of symptoms are basically identical, without significant difference, have comparability.
2, medicament selection:
Treatment group takes the Chinese medicinal capsule obtained by the embodiment of the present invention 1, oral, every day 2 times, the most each 1 time, each 1, meal Rear warm water delivery service；It within 15 days, it is 1 course for the treatment of.
Matched group gives tiapridal tablet, each 50mg, is administered orally, three times a day.The course for the treatment of is with treatment group.
2 courses for the treatment of are treated in smelting continuously, contrast two groups of curative effects.
3, efficacy determination:
(1) cure: twitch and be wholly absent, recover normal living and studying.
(2) take a turn for the better: twitch degree substantially alleviates, each remission, but because flu, anxious state of mind etc. are because have little sending out.
(3) do not heal: before and after treatment, symptom is without substantially changing.
4, result:
Selecting in the treatment group of the embodiment of the present invention 1 Chinese medicinal capsule, cure 15 examples, take a turn for the better 5 examples, the most 1 example, untoward reaction 0 example, Cure rate 75%, total effective rate 95%.Average cure time 18.4 days.Healing and improvement patient are followed the tracks of and follows up a case by regular visits to 24 months, without 1 example Recurrence.
Curing 5 examples in matched group, take a turn for the better 7 examples, the most 8 examples, cure rate 25%, total effective rate 60%.Average cure time 28.9 days.Healing and improvement patient are followed the tracks of and follows up a case by regular visits to 24 months, 2 examples recurrences.
Result above shows, the cure rate for the treatment of group and total effective rate are apparently higher than matched group.
Embodiment 2
Weigh: Europe Herba melissae axillaris 16 grams, Herba Triglochinis 10 grams, 8 grams of Poria, the Rhizoma Atractylodis Macrocephalae 7 grams, Herba Artemisiae Annuae 8 grams, Concretio Silicea Bambusae 10 grams, Folium cordylines fruticosae 9 Gram, Scorpio 6 grams, Rhizoma Acori Graminei 5 grams, pittosporm root 7 grams, Rhizoma Arisaematis 14 grams, Herba Murdanniae Divergentis 12 grams, Flos Rosae Rugosae 11 grams, Radix Rhapontici 8 grams, Ziziphi Spinosae Core 6 grams, Flos Albiziae 6 grams, Liquor Fructus Citri sarcodactylis Distillata 15 grams, Endocarpium Citri tangerinae 6 grams.Preparation method is with embodiment 1.
In 10 infantile spasm tourette syndrome patients of the Chinese medicinal capsule that the selection embodiment of the present invention 2 is made, cure 6 Example, take a turn for the better 2 examples, the most 2 examples, cure rate 60%, total effective rate 80%.Following the tracks of healing and improvement patient and follow up a case by regular visits to 24 months, 1 example is multiple Send out.
Embodiment 3
Weigh: Europe Herba melissae axillaris 16 grams, 8 grams of Poria, the Rhizoma Atractylodis Macrocephalae 7 grams, Herba Artemisiae Annuae 8 grams, Concretio Silicea Bambusae 10 grams, Folium cordylines fruticosae 9 grams, Scorpio 6 grams, stone Rhizoma Acori Graminei 5 grams, pittosporm root 7 grams, Rhizoma Arisaematis 14 grams, Herba Murdanniae Divergentis 12 grams, Flos Rosae Rugosae 11 grams, Semen Ziziphi Spinosae 6 grams, Flos Albiziae 6 grams, Liquor Fructus Citri sarcodactylis Distillata 15 grams, Endocarpium Citri tangerinae 6 grams.Preparation method is with embodiment 1.
In 10 infantile spasm tourette syndrome patients of the Chinese medicinal capsule that the selection embodiment of the present invention 3 is made, cure 5 Example, take a turn for the better 2 examples, the most 3 examples, cure rate 50%, total effective rate 70%.Following the tracks of healing and improvement patient and follow up a case by regular visits to 24 months, 2 examples are multiple Send out.
Embodiment 4
Weigh: Europe Herba melissae axillaris 16 grams, 8 grams of Poria, the Rhizoma Atractylodis Macrocephalae 7 grams, Herba Artemisiae Annuae 8 grams, Concretio Silicea Bambusae 10 grams, Folium cordylines fruticosae 9 grams, Scorpio 6 grams, stone Rhizoma Acori Graminei 5 grams, pittosporm root 7 grams, Rhizoma Arisaematis 14 grams, Herba Murdanniae Divergentis 12 grams, Flos Rosae Rugosae 11 grams, Semen Ziziphi Spinosae 6 grams, Flos Albiziae 6 grams, Liquor Fructus Citri sarcodactylis Distillata 15 grams, Endocarpium Citri tangerinae 6 grams, 7 grams of Cassia siamea leaf, Folium Alstoniae Scholaris 6 grams.Preparation method is with embodiment 1.
Embodiment 5
Weigh: Europe Herba melissae axillaris 16 grams, 8 grams of Poria, the Rhizoma Atractylodis Macrocephalae 7 grams, Herba Artemisiae Annuae 8 grams, Concretio Silicea Bambusae 10 grams, Folium cordylines fruticosae 9 grams, Scorpio 6 grams, stone Rhizoma Acori Graminei 5 grams, pittosporm root 7 grams, Rhizoma Arisaematis 14 grams, Herba Murdanniae Divergentis 12 grams, Flos Rosae Rugosae 11 grams, Semen Ziziphi Spinosae 6 grams, Flos Albiziae 6 grams, Liquor Fructus Citri sarcodactylis Distillata 15 grams, Endocarpium Citri tangerinae 6 grams, 7 grams of Cassia siamea leaf, Folium Alstoniae Scholaris 6 grams, Herba Triglochinis 10 grams, Herba Gonostegiae hirtae 6 grams.Preparation method is with embodiment 1.
Embodiment 6
Weigh: Europe Herba melissae axillaris 16 grams, 8 grams of Poria, the Rhizoma Atractylodis Macrocephalae 7 grams, Herba Artemisiae Annuae 8 grams, Concretio Silicea Bambusae 10 grams, Folium cordylines fruticosae 9 grams, Scorpio 6 grams, stone Rhizoma Acori Graminei 5 grams, pittosporm root 7 grams, Rhizoma Arisaematis 14 grams, Herba Murdanniae Divergentis 12 grams, Flos Rosae Rugosae 11 grams, Semen Ziziphi Spinosae 6 grams, Flos Albiziae 6 grams, Liquor Fructus Citri sarcodactylis Distillata 15 grams, Endocarpium Citri tangerinae 6 grams, 7 grams of Cassia siamea leaf, Folium Alstoniae Scholaris 6 grams, Herba Triglochinis 10 grams, Corvus macrorhuchus liver 11 grams, Herba Gonostegiae hirtae 6 grams.Preparation method is same Embodiment 1.
Embodiment 7
Weigh: Europe Herba melissae axillaris 16 grams, 8 grams of Poria, the Rhizoma Atractylodis Macrocephalae 7 grams, Herba Artemisiae Annuae 8 grams, Concretio Silicea Bambusae 10 grams, Folium cordylines fruticosae 9 grams, Scorpio 6 grams, stone Rhizoma Acori Graminei 5 grams, pittosporm root 7 grams, Rhizoma Arisaematis 14 grams, Herba Murdanniae Divergentis 12 grams, Flos Rosae Rugosae 11 grams, Semen Ziziphi Spinosae 6 grams, Flos Albiziae 6 grams, Liquor Fructus Citri sarcodactylis Distillata 15 grams, Endocarpium Citri tangerinae 6 grams, 7 grams of Cassia siamea leaf, Folium Alstoniae Scholaris 6 grams, brocade spent 3 grams, Herba Triglochinis 10 grams, Corvus macrorhuchus liver 11 grams, white wolf Herba Alii fistulosi 9 grams, Herba Gonostegiae hirtae 6 grams.Preparation method is with embodiment 1.
Embodiment 8
Weigh: Europe Herba melissae axillaris 16 grams, 8 grams of Poria, the Rhizoma Atractylodis Macrocephalae 7 grams, Herba Artemisiae Annuae 8 grams, Concretio Silicea Bambusae 10 grams, Folium cordylines fruticosae 9 grams, Scorpio 6 grams, stone Rhizoma Acori Graminei 5 grams, pittosporm root 7 grams, Rhizoma Arisaematis 14 grams, Herba Murdanniae Divergentis 18 grams, Flos Rosae Rugosae 11 grams, Semen Ziziphi Spinosae 6 grams, Flos Albiziae 6 grams, Liquor Fructus Citri sarcodactylis Distillata 15 grams, Endocarpium Citri tangerinae 6 grams, 7 grams of Cassia siamea leaf, Folium Alstoniae Scholaris 6 grams, Herba leucadis zeylanicae 6 grams, Herba Triglochinis 10 grams, Corvus macrorhuchus liver 11 grams, white wolf Herba Alii fistulosi 9 grams, Herba Gonostegiae hirtae 6 grams.Preparation method is with embodiment 1.
Selecting the infantile spasm tourette syndrome patient 20 example clinical observation in my institute's diagnosis and treatment, clinical symptoms all meets children's Coprolalia syndrome diagnosis and treatment standard.Patient is randomly divided into 5 groups, takes the Chinese medicinal capsule that embodiment of the present invention 4-8 is made respectively, Oral, every day 2 times, the most each 1 time, each 1, warm water delivery service after meal, record curative effect is as follows:
Case Cure Take a turn for the better Do not heal Untoward reaction Recur in 2 years Average cure time
Embodiment 4 4 2 1 1 0 1 29 days
Embodiment 5 4 2 2 0 0 1 27 days
Embodiment 6 4 3 1 0 0 0 24 days
Embodiment 7 4 4 0 0 1 0 21 days
Embodiment 8 4 4 0 0 0 0 18 days
Obviously, the above embodiment of the present invention is only for clearly demonstrating example of the present invention, and is not to this The restriction of bright embodiment, such as the present invention is in addition to making capsule, can also be used with common technology and makes other peroral dosage forms.Phase Close Chinese medicine and pharmacology thereof all can be obtained by existing open source literature and network, it is also possible to the medical material by close effect is the most alternative. For those of ordinary skill in the field, the change of other multi-form can also be made on the basis of the above description Or variation.Here cannot all of embodiment be given exhaustive.Every belong to that technical scheme extended out aobvious And the change being clear to or variation are still in the row of protection scope of the present invention.

Claims (2)

1. the Chinese medicinal capsule being used for treating infantile spasm tourette syndrome, it is characterised in that by following weight proportion Medical material is prepared from: Europe Herba melissae axillaris 16 parts, Herba Triglochinis 10 parts, white wolf Herba Alii fistulosi 9 parts, 8 parts of Poria, the Rhizoma Atractylodis Macrocephalae 7 parts, Corvus macrorhuchus liver 11 parts, green grass or young crops Artemisia 8 parts, Concretio Silicea Bambusae 10 parts, Folium cordylines fruticosae 9 parts, Scorpio 6 parts, Rhizoma Acori Graminei 5 parts, pittosporm root 7 parts, Rhizoma Arisaematis 14 parts, Herba Murdanniae Divergentis 12 parts, Flos Rosae Rugosae 11 parts, Radix Rhapontici 8 parts, Semen Ziziphi Spinosae 6 parts, Flos Albiziae 6 parts, Liquor Fructus Citri sarcodactylis Distillata 15 parts, Endocarpium Citri tangerinae 6 parts.
The preparation method of a kind of Chinese medicinal capsule for treating infantile spasm tourette syndrome the most according to claim 1, It is characterized in that, mix after above-mentioned medical material in addition to Liquor Fructus Citri sarcodactylis Distillata is gone respectively the removal of impurity, send into drying baker interior in 120 DEG C of temperature Lower drying, is ground into 100-130 mesh smalls, then mixs homogeneously with Liquor Fructus Citri sarcodactylis Distillata, presses 0.5g/ grain and load glue after disinfection by ultraviolet light Capsule, is finished product.
CN201610780199.3A 2016-08-31 2016-08-31 A kind of Chinese medicinal capsule for treating infantile spasm tourette syndrome Pending CN106177590A (en)

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