CN103656048A - Drug for treating cow mastitis and preparation method thereof - Google Patents
Drug for treating cow mastitis and preparation method thereof Download PDFInfo
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- CN103656048A CN103656048A CN201310722875.8A CN201310722875A CN103656048A CN 103656048 A CN103656048 A CN 103656048A CN 201310722875 A CN201310722875 A CN 201310722875A CN 103656048 A CN103656048 A CN 103656048A
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Abstract
The invention discloses a drug for treating cow mastitis and a preparation method thereof. The drug comprises the following raw medicinal materials: astragalus membranaceus, codonopsis pilosula, phtheirospermum tenuisectum bur, angelica sinensis, formosan lattuce herb, notopterygium root, isatis root, ligusticum wallichii, parameria benth, boston ivy, flavedo, bodhi incense, liquorice, acanthopanax, caulis akebiae, rhizoma cyperi, colla corii asini, cactus, crape myrtle, pericarpium citri reticulatae, gorgon fruit, endothelium corneum gigeriae galli, medicated leaven and hawthorn. The drug for treating the cow mastitis has the following benefits: using heat clearing, poison removal, blood activation, blood stasis removal, painful menstruation relieving and collaterals activation as main treatment principles, the invention provides the drug for treating the cow mastitis; the drug can improve the immunity and disease resistance of cows, and has the advantages of good treating effect, difficult relapse, low toxic and side effects and no residue; the drug comprises oral solution and external ointment, which are used together to achieve better treating effect.
Description
Technical field
The present invention relates to herbal medicine technical field, particularly a kind of medicine that is used for the treatment of mammitis of cow and preparation method thereof.
Background technology
Mammitis of cow is the inflammation of mammary glandular cell and mammary gland interstitial.Cause the pathogen of breast inflammation, approximately 85% is streptococcus, micrococcus scarlatinae etc., and 5% is staphylococcus.Other have tubercule bacillus, Brucella, corynebacterium pyogenes, escherichia coli, mycoplasma and mycete etc.The economic loss that mammitis of cow causes is very large, is first that milk yield reduces, and is secondly that disease breast can not be drunk, and even gives people's communicate illness, and people ' s health is worked the mischief.If mastitis can not be treated in time, often make mastatrophy, milk can not be sold, and even completely loses Lactation.Therefore to perform the work of control mastitis.
At present, adopt antibiotic therapy mammitis of cow, therapeutic effect is undesirable more, and drug tolerant bacteria also can be by milk-born infection to people, in milch cow, residual antibiotic also can bring out human body generation allergy in addition, and therefore, the non-antibiotic therapy of mammitis of cow causes people's concern gradually.
The traditional Chinese medicine of China is conceived to integral body while applying, and emphasizes to regulate allomeric function, improves the premunition of body self.Chinese medicine belongs to natural drug, has antibacterial, antiinflammatory, is difficult for making pathogenic bacterium to produce the effect of drug resistance and immunostimulant, has the feature of safety, efficient, low toxicity, low-residual, can overcome the drawback that a large amount of use antibiotic bring; Chinese herbal medicine has enhancing human body immunity function, improves animal anti-stress, anti-disease ability, improves the multiple efficacies such as breeding performonce fo animals, and have no drug resistance, noresidue, toxic and side effects be little, demonstrates unique advantage aspect livestock and poultry cultivation.
Summary of the invention
Technical problem to be solved by this invention is to be to provide a kind of medicine that is used for the treatment of mammitis of cow and preparation method thereof, adopts this medicine to have advantages of that curative effect is high, toxic and side effects is little, noresidue, do not develop immunity to drugs, non-environmental-pollution, and can increase Abwehrkraft des Koepers and short treating period the treatment of mammitis of cow.
In order to realize foregoing invention object, the invention provides a kind of medicine that is used for the treatment of mammitis of cow, it is characterized in that, described medicine comprises following raw medicinal material: the Radix Astragali, Radix Codonopsis, Phtheirospermum tenuisectum Bur.et Franch., Radix Angelicae Sinensis, Herba Lactucae formosanae, Rhizoma Et Radix Notopterygii, Radix Isatidis, Rhizoma Chuanxiong, meropodium pearl, parthenocissus, Pericarpium Citri junoris, bodhi perfume, Radix Glycyrrhizae, Radix Et Caulis Acanthopanacis Senticosi, Caulis Akebiae, Rhizoma Cyperi, Colla Corii Asini, Radix et Caulis Opuntiae Dillenii, Lagerstroemia indica L., Pericarpium Citri Reticulatae, Semen Euryales, Endothelium Corneum Gigeriae Galli, Massa Medicata Fermentata and Fructus Crataegi.
Described medicine is comprised of the raw medicinal material of following parts by weight: Radix Astragali 15-30 weight portion, Radix Codonopsis 10-20 weight portion, Phtheirospermum tenuisectum Bur.et Franch. 10-15 weight portion, Radix Angelicae Sinensis 10-20 weight portion, Herba Lactucae formosanae 15-25 weight portion, Rhizoma Et Radix Notopterygii 10-25 weight portion, Radix Isatidis 10-16 weight portion, Rhizoma Chuanxiong 13-20 weight portion, meropodium pearl 10-15 weight portion, parthenocissus 10-15 weight portion, Pericarpium Citri junoris 10-20 weight portion, the fragrant 15-20 weight portion of bodhi, Radix Glycyrrhizae 15-20 weight portion, Radix Et Caulis Acanthopanacis Senticosi 10-20 weight portion, Caulis Akebiae 10-15 weight portion, Rhizoma Cyperi 10-15 weight portion, Colla Corii Asini 10-15 weight portion, Radix et Caulis Opuntiae Dillenii 10-15 weight portion, Lagerstroemia indica L. 10-20 weight portion, Pericarpium Citri Reticulatae 10-20 weight portion, Semen Euryales 10-15 weight portion, Endothelium Corneum Gigeriae Galli 10-15 weight portion, Massa Medicata Fermentata 15-20 weight portion and Fructus Crataegi 10-15 weight portion.
Described medicine is preferably comprised of the raw medicinal material of following parts by weight: Radix Astragali 20-25 weight portion, Radix Codonopsis 13-18 weight portion, Phtheirospermum tenuisectum Bur.et Franch. 11-14 weight portion, Radix Angelicae Sinensis 12-17 weight portion, Herba Lactucae formosanae 18-22 weight portion, Rhizoma Et Radix Notopterygii 15-20 weight portion, Radix Isatidis 12-14 weight portion, Rhizoma Chuanxiong 15-18 weight portion, meropodium pearl 12-14 weight portion, parthenocissus 12-14 weight portion, Pericarpium Citri junoris 13-18 weight portion, the fragrant 16-18 amount part of bodhi, Radix Glycyrrhizae 15-18 weight portion, Radix Et Caulis Acanthopanacis Senticosi 13-18 weight portion, Caulis Akebiae 11-14 weight portion, Rhizoma Cyperi 12-14 weight portion, Colla Corii Asini 11-14 weight portion, Radix et Caulis Opuntiae Dillenii 11-14 weight portion, Lagerstroemia indica L. 12-18 weight portion, Pericarpium Citri Reticulatae 12-17 weight portion, Semen Euryales 11-14 weight portion, Endothelium Corneum Gigeriae Galli 11-14 weight portion, Massa Medicata Fermentata 17-19 weight portion and Fructus Crataegi 12-14 weight portion.
Described medicine is preferably comprised of the raw medicinal material of following parts by weight: the Radix Astragali 23 weight portions, Radix Codonopsis 15 weight portions, Phtheirospermum tenuisectum Bur.et Franch. 13 weight portions, Radix Angelicae Sinensis 15 weight portions, Herba Lactucae formosanae 20 weight portions, Rhizoma Et Radix Notopterygii 17 weight portions, Radix Isatidis 13 weight portions, Rhizoma Chuanxiong 17 weight portions, meropodium pearl 13 weight portions, parthenocissus 13 weight portions, Pericarpium Citri junoris 15 weight portions, fragrant 17 amounts part of bodhi, Radix Glycyrrhizae 16 weight portions, Radix Et Caulis Acanthopanacis Senticosi 15 weight portions, Caulis Akebiae 12 weight portions, Rhizoma Cyperi 13 weight portions, Colla Corii Asini 12 weight portions, Radix et Caulis Opuntiae Dillenii 13 weight portions, Lagerstroemia indica L. 15 weight portions, Pericarpium Citri Reticulatae 14 weight portions, Semen Euryales 13 weight portions, Endothelium Corneum Gigeriae Galli 13 weight portions, Massa Medicata Fermentata 18 weight portions and Fructus Crataegi 13 weight portions.
Described medicine also comprises: Formica fusca, Radix Bupleuri, Ganoderma and Radix Rhodiolae.
Described medicine is preferably comprised of the raw medicinal material of following parts by weight: Radix Astragali 15-30 weight portion, Radix Codonopsis 10-20 weight portion, Phtheirospermum tenuisectum Bur.et Franch. 10-15 weight portion, Radix Angelicae Sinensis 10-20 weight portion, Herba Lactucae formosanae 15-25 weight portion, Rhizoma Et Radix Notopterygii 10-25 weight portion, Radix Isatidis 10-16 weight portion, Rhizoma Chuanxiong 13-20 weight portion, meropodium pearl 10-15 weight portion, parthenocissus 10-15 weight portion, Pericarpium Citri junoris 10-20 weight portion, the fragrant 15-20 weight portion of bodhi, Radix Glycyrrhizae 15-20 weight portion, Radix Et Caulis Acanthopanacis Senticosi 10-20 weight portion, Caulis Akebiae 10-15 weight portion, Rhizoma Cyperi 10-15 weight portion, Colla Corii Asini 10-15 weight portion, Radix et Caulis Opuntiae Dillenii 10-15 weight portion, Lagerstroemia indica L. 10-20 weight portion, Pericarpium Citri Reticulatae 10-20 weight portion, Semen Euryales 10-15 weight portion, Endothelium Corneum Gigeriae Galli 10-15 weight portion, Massa Medicata Fermentata 15-20 weight portion, Fructus Crataegi 10-15 weight portion, Formica fusca 10-16 weight portion, Radix Bupleuri 15-20 weight portion, Ganoderma 10-15 weight portion and Radix Rhodiolae 10-15 weight portion.
Described medicine is preferably comprised of the raw medicinal material of following parts by weight: Radix Astragali 20-25 weight portion, Radix Codonopsis 13-18 weight portion, Phtheirospermum tenuisectum Bur.et Franch. 11-14 weight portion, Radix Angelicae Sinensis 12-17 weight portion, Herba Lactucae formosanae 18-22 weight portion, Rhizoma Et Radix Notopterygii 15-20 weight portion, Radix Isatidis 12-14 weight portion, Rhizoma Chuanxiong 15-18 weight portion, meropodium pearl 12-14 weight portion, parthenocissus 12-14 weight portion, Pericarpium Citri junoris 13-18 weight portion, the fragrant 16-18 amount part of bodhi, Radix Glycyrrhizae 15-18 weight portion, Radix Et Caulis Acanthopanacis Senticosi 13-18 weight portion, Caulis Akebiae 11-14 weight portion, Rhizoma Cyperi 12-14 weight portion, Colla Corii Asini 11-14 weight portion, Radix et Caulis Opuntiae Dillenii 11-14 weight portion, Lagerstroemia indica L. 12-18 weight portion, Pericarpium Citri Reticulatae 12-17 weight portion, Semen Euryales 11-14 weight portion, Endothelium Corneum Gigeriae Galli 11-14 weight portion, Massa Medicata Fermentata 17-19 weight portion, Fructus Crataegi 12-14 weight portion, Formica fusca 12-14 weight portion, Radix Bupleuri 16-19 weight portion, Ganoderma 11-13 weight portion and Radix Rhodiolae 11-14 weight portion.
Described medicine is preferably comprised of the raw medicinal material of following parts by weight: the Radix Astragali 23 weight portions, Radix Codonopsis 15 weight portions, Phtheirospermum tenuisectum Bur.et Franch. 13 weight portions, Radix Angelicae Sinensis 15 weight portions, Herba Lactucae formosanae 20 weight portions, Rhizoma Et Radix Notopterygii 17 weight portions, Radix Isatidis 13 weight portions, Rhizoma Chuanxiong 17 weight portions, meropodium pearl 13 weight portions, parthenocissus 13 weight portions, Pericarpium Citri junoris 15 weight portions, fragrant 17 amounts part of bodhi, Radix Glycyrrhizae 16 weight portions, Radix Et Caulis Acanthopanacis Senticosi 15 weight portions, Caulis Akebiae 12 weight portions, Rhizoma Cyperi 13 weight portions, Colla Corii Asini 12 weight portions, Radix et Caulis Opuntiae Dillenii 13 weight portions, Lagerstroemia indica L. 15 weight portions, Pericarpium Citri Reticulatae 14 weight portions, Semen Euryales 13 weight portions, Endothelium Corneum Gigeriae Galli 13 weight portions, Massa Medicata Fermentata 18 weight portions, Fructus Crataegi 13 weight portions, Formica fusca 13 weight portions, Radix Bupleuri 17 weight portions, Ganoderma 12 weight portions and Radix Rhodiolae 13 weight portions.
In order better to realize foregoing invention object, the present invention also provides a kind of preparation method that is used for the treatment of the medicine of mammitis of cow, and described preparation method comprises the following steps:
The first step, is mixed in proportion all raw medicinal materials, is ground into 100 order～200 object powder, add the water with respect to 3～5 times of mixture qualities, at the temperature of 90 ℃～100 ℃, decoct 30 minutes～1 hour, decoction liquor is filtered, and obtains the first filtrate and filtering residue;
Second step, the filtering residue that the first step is obtained adds the water with respect to 1～3 times of first step mixture quality, at the temperature of 90 ℃～100 ℃, decocts 30 minutes～1 hour, and decoction liquor is filtered, and obtains the second filtrate;
The 3rd step, merges the first filtrate and the second filtrate, and concentrating under reduced pressure is except desolventizing, obtain and get dry extract, dry cream is put into spray dryer dry, guarantee that inlet temperature is at 170 ℃～190 ℃, 60 ℃～80 ℃ of leaving air temps, are ground into 200 order～400 orders subsequently, obtain drug powder.
In order better to realize foregoing invention object, the present invention also provides a kind of preparation method that is used for the treatment of the medicine of mammitis of cow, and described medicine is emulsifiable paste, and described preparation method is:
Take by weight all raw medicinal materials and soak 1-2 hour, be then placed in multi-function extractor, decoct for the first time amount of water and be the 5-10 of medical material doubly, decoct, while being heated to 100 ℃, start timing, micro-boiling after 2 hours, filters and emits medicinal liquid from feed opening, puts in fluid reservoir; Decoct for the second time, amount of water is that medical material 5-10 doubly measures, and is heated to 100 ℃, and micro-boiling after 2 hours extracted medicinal liquid out, merges with the medicinal liquid decocting for the first time; By merging in the decoction liquor suction concentrating under reduced pressure tank of latter 2 times, be decompressed to 0.03-0.08MPa, temperature remains on 60-80 ℃, and being concentrated into relative density is 1.20, and the extractum that temperature to 60 is ℃-70 ℃ is cooling; The Margarita powder of getting extractum weight 10% adds in extractum, stirs, and tinning after ultraviolet radiation sterilizing.
The beneficial effect that the technical scheme that the embodiment of the present invention provides is brought is: the present invention take heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, dysmenorrhea is active is primary treatment principle, a kind of medicine that is used for the treatment of mammitis of cow is provided, can improve immunity and the resistance against diseases of milch cow, there is good effect, be difficult for recurrence, toxic and side effects is little, noresidue; Wherein, medicine of the present invention comprises Oral preparation and medicinal external emulsifiable paste, jointly uses therapeutic effect more excellent.
The specific embodiment
Mammitis of cow symptom is the inflammation of breast essence, interstitial.The cause of disease is many by due to mechanical irritation, pathogenic microorganism immersion and the damage of chemicals rationality.1. environmental management factor: environmental condition is as muddy in cowshed, cattle bed and sports ground can't bear, and around dirty is too many for cattle body and breast, and sanitary condition is too poor, temperature too high (more than 36 ℃) or too low (5 ℃ are following) etc.The condition of milking does not meet lactogenic physiological requirement, as too high in negative pressure of vacuum, too low, and unsuitable scouring breast and embarkation are milked.2. pathogenic infection: up to the present, people have isolated 150 kinds of pathogenic microorganisms from cow mammary gland tissue, and modal have 23 kinds, and wherein antibacterial is 14 kinds, 2 kinds of mycoplasmas, 7 kinds, fungus and virus.What wherein sickness rate was the highest is staphylococcus aureus, escherichia coli, streptococcus, and mycoplasma, fungus-caused mastitis sickness rate rise year by year in recent years.3. cattle oneself factor: contain phase or the too high milch cow of milk production in lactogenic, body energy is in negative balance resistance, aged cattle, polyembryony time cattle relative incidence rate are high.4. Secondary cases factor: the author finds the babesiasis of milch cow in clinical treatment in recent years, also can become the paathogenic factor of mammitis of cow, and treatment is got up also very difficult.There is again puerperal infection also can cause occurring mastitis.For this reason, after being made a definite diagnosis, Secondary cases mastitis first should control protopathy.
Mammitis of cow can be divided into serosity mastitis, fiber disposition mucositis mastitis, suppurative mastitis, hemorrhagic mastitis, gangrenous mastitis and latent mammitis.Clinic mastitis: be the inflammation of breast interstitial, essence or interstitial parenchymal tissue.It is characterized in that milk degeneration, breast tissue present swelling to some extent, warm and pain.Different with coincident with severity degree of condition according to course of disease length, can be divided into the most acute, acute, subacute and chronic mammitis.The most acute: suddenly, development is rapid, the multiple 1 Ge Ru district of being born in morbidity; Latent mammitis: claim again Subclinical mastitis.For a kind of mastitis without clinical symptoms performance.It is characterized in that breast and milk are abnormal as seen without naked eyes, yet milk changes on physicochemical property, bacteriology.Concrete manifestation pH value more than 7.0, is meta-alkalescence; In breast, there are lump in breast, floccule, fiber; Sodium chloride content is more than 0.14%, somatic number 500,000/more than mL, bacterial population and electric conductivity value increase; Chronic case: because mammary gland tissue is gradual inflammatory process, lactogenic acinus wrecks in a big way, mammary gland tissue generation fibrosis, often causes mastatrophy and induration of breast.
Chinese veterinarian's traditional theory thinks, mastitis is acute mastitis, is expectorant, wet, gas, blood stagnation knot is loose and be scorching.Because feeding and management is not good at, the ground that lying on bed for a long time is damp and hot, steams on damp and hot poison, infringement breast; Or because of excessiveness of stomach-heat, stagnation of QI due to depression of the liver, newborn network loses smooth so that breast coagulation of QI-blood, stasis and raw carbuncle; Or because calf inhales breast, milk being stagnated, breast distensions etc. are former thereby cause primary disease.Therefore, the present invention take that heat-clearing and toxic substances removing, dredging collateral are invigorated blood circulation, reducing swelling and alleviating pain, active lactogenesis are Therapeutic Principle, a kind of medicine that is used for the treatment of mammitis of cow is provided, and medicine comprises: the Radix Astragali, Radix Codonopsis, Phtheirospermum tenuisectum Bur.et Franch., Radix Angelicae Sinensis, Herba Lactucae formosanae, Rhizoma Et Radix Notopterygii, Radix Isatidis, Rhizoma Chuanxiong, meropodium pearl, parthenocissus, Pericarpium Citri junoris, bodhi perfume, Radix Glycyrrhizae, Radix Et Caulis Acanthopanacis Senticosi, Caulis Akebiae, Rhizoma Cyperi, Colla Corii Asini, Radix et Caulis Opuntiae Dillenii, Lagerstroemia indica L., Pericarpium Citri Reticulatae, Semen Euryales, Endothelium Corneum Gigeriae Galli, Massa Medicata Fermentata and Fructus Crataegi.
Wherein, the pharmacological property of each raw medicinal material is as follows:
The Radix Astragali: take tonify deficiency as main, energy invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.For insufficiency of vital energy and blood, skin infection cave in, difficulty in discharging of pus or burst and do not hold back person for a long time.The Radix Astragali has the function of good promoting pus discharge and tissue regeneration strengthening, i.e. the abscess suppuration granulation promoting of disunion for a long time.Modern medicine study shows, the Radix Astragali includes and multiple antibiotic effective ingredient, and immunologic function that can enhancing body, therefore can also be for preventing the generation of some infectious disease.< < book on Chinese herbal medicine meets former > > to carry: " all void of Radix Astragali energy tonifying five ZANG-organs, controls stringy pulse spontaneous perspiration, rushes down YIN-fire, removes lung-heat, losslessly sends out, and has antiperspirant to stop." be the good medicine of promoting resistance and defence disease.
Radix Codonopsis: property is flat, sweet in the mouth, micro-acid.Return spleen, lung meridian.Invigorating the spleen and replenishing QI, spleen invigorating lung benefiting.For deficiency of the spleen and lung, the cardiopalmus of breathing hard, anorexia and loose stool, dyspnea due to deficiency cough, interior-heat is quenched one's thirst.The just > > of < < book on Chinese herbal medicine carries: Radix Codonopsis power energy spleen reinforcing nourishing the stomach, and the lung moistening and production of body fluid promoting, gas in tendon fortune, this is very mutually not far away with Radix Ginseng.Its outstanding valuable person, spleen invigorating fortune and not dry, grows stomach-Yin and wet, and lung moistening and do not violate is cold and coolly nourished blood and is not partially grown greasyly, inspires clear sun, gas in vibration, and without just dry fraud.Radix Astragali QI invigorating, can rise enriching spleen-QI, again can lung benefiting consolidating superficial resistance.Radix Codonopsis QI invigorating, can only spleen invigorating QI invigorating, and without the power of consolidating superficial resistance, but Radix Codonopsis can also supplementing QI for promoting the production of body fluid, and the Radix Astragali is without the effect of promoting the production of body fluid, and the Radix Astragali is held concurrently can diuretic, and Radix Codonopsis is without diuretic effect.This two tastes medicine share can invigorating the spleen and replenishing QI, improves resistance.
Phtheirospermum tenuisectum Bur.et Franch.: property is flat, acrid in the mouth is bitter.Function cures mainly: tranquilizing by nourishing the heart, hemostasis.Control and have a weak heart, cardiopalmus, cough sputum mixed with blood.Heat-clearing and toxic substances removing, tranquilizing by nourishing the heart, pain relieving.Be used for having a weak heart, cardiopalmus, cough, sputum mixed with blood, laryngopharynx swelling and pain, fracture; Serpentis, lyssodexis are controlled in external.
Radix Angelicae Sinensis: sweet in the mouth and weighing, therefore specially can enrich blood, its gas is light and pungent, thus again can promoting the circulation of blood, invigorating middle warmer has, in row, has benefit, really the gas medicine in blood, the also panacea in blood.About mending to mend of assistant, thus can support nutrition blood, QI invigorating spermatogenesis, settling five organs, body by force, beneficial mind, all tangible deficient diseases, nothing is unsuitable.Assistant logical to attack, therefore the pain relieving constipation of dispelling, relieving rigidity of muscles and joints, controls contracture, paralysis, the card such as dry, puckery.Nutrient QI being deficient and exterior syndrome being not relieved person, assistant is with agent such as bavin, Pueraria lobota, fiber crops, osmanthus, the Biao Weire that can fall apart greatly, and show not hold back person, and help with Radix Et Rhizoma Rhei and so on, again can consolidating superficial resistance.Precisely because gas Xin Erdong, thus want its quiet person when keeping away it, the sliding benefaction of property, stool is not consolidated person when keeping away it.All cloudy moderate heat Sheng persons, the active blood of Radix Angelicae Sinensis, also non-institute is suitable, cloudy deficiency of YANG of middle-JIAO person, Radix Angelicae Sinensis can nourish blood, and is indispensable.
Herba Lactucae formosanae: bitter in the mouth; Cold in nature, function cures mainly: heat-clearing and toxic substances removing; Wind-damp dispelling; Invigorate blood circulation.Main furuncle carbuncle; Laryngopharynx swelling and pain; Scabies; Hemorrhoid; Venom; Rheumatic arthralgia; Traumatic injury.
Rhizoma Et Radix Notopterygii: return bladder; Kidney channel.Nature and flavor: acrid in the mouth; Bitter; Warm in nature.Loose exterior cold; Wind-damp dispelling; Profit joint; Pain relieving.Loose exterior cold, wind-damp dispelling, sharp joint.The wind and cold that cures cold, has a headache lossless, anemofrigid-damp arthralgia, stiffness of the nape muscular contracture, joint ache, edema due to wind pathogen edema, skin sore.For impotence and seminal emission, enuresis frequent micturition, chills and pain of the waist and kness, suffers from a deficiency of the kidney and breathes heavily, Diarrhoea; External curing vitiligo, alopecia areata.The cold expelling that induces sweat, expelling wind and dampness, pain relieving.For affection of exogenous wind-cold, fever with aversion to cold, the cards such as headache general pain.This product has stronger dispersing wind-cold and analgesic effect.Normal and Radix Saposhnikoviae, the Radix Angelicae Dahuricae, Herba Asari are equal to use, as Notoptreygium Decoction of Nine Ingredients.Arthrodynia of extremities, aching pain in should and back due to attacking for wind-cold damp pathogen, especially more applicable with upper part of the body pain.This product can be dispeled the wind and be won temperature, dispersing cold for relieving pain.Normal and Radix Saposhnikoviae, same use, as JUANBI TANG.< < property of medicine opinion > >: " control harmful wind, aphonia in silence, the blood leprosy of itching, hands and feet caused by paralysis, the askew heresy of actinal surface, insensitive impediment all over more." < < Japan hanako materia medica > >: " and control a wind cutting gas, muscles and bones fist contraction, extremity are thin bad, head revolves the red pain of eyes and fullness in the epigastrium especially referring to the abcess of the abdomen in ancient times aqueous vapor, five kinds of strain and seven kinds of impairment, deficient cold air, joint ache, tonneau the five internal organs." < < pearl sac > >: " Taiyang channel headache, removes all arthralgias, also can warm gallbladder." the smart > > that wants of < < product remittance: " and main all joints being painful all over, flesh table eight winds coming from eight orientations harmful climatic factors, except new and old rheumatism, row's slough cellulitis skin ulcer." < < Bencao Beiyao > >: " eliminating pathogen in the liver gas, searches liver-wind, and dispelling the wind and dampness pathogens is fought mutually, herbal classic (sun) headache, governor vessel is disease, back rigidity and fainting, tonic convulsion rigidity with sweating, aphasia due to apoplexy, head revolves conjunctival congestion." < < can approximately cure mirror > >: " control heresy and close the loathing of cold, high fever is lossless.”
Radix Isatidis: resisting pathogenic microbes effect: Radix Isatidis has inhibitory action to various bacteria.Infusion has inhibitory action in various degree to bacillus subtilis, staphylococcus aureus, sarcine, escherichia coli, Bacillus typhi, Salmonella paratyphi, dysentery (will he, Fu Shi) bacillus, bacillus enteritidis etc.; Acetone leachate also has similar effect, and to Hemolytic streptococcus effective (all using agar aperture flat band method).Similar to the bacteriostasis of A type meningococcus and Bulbus Allii, Flos Lonicerae.The 68-1 of the section strain of infected by influenza PR8Zhu He capital has obvious inhibitory action.In vitro Radix Isatidis is killed leptospiral effect.To cardiovascular effect: these product can make the in vitro rabbit ear and rat lower limb perfusion flow increase, and improve Rabbit Mesentery microcirculation, reduce the blood pressure of Anaesthetic Rabbits, reduce capillary permeability, and mouse cardiac muscle oxygen consumption is declined.Anticoagulant effect Radix Isatidis has remarkable inhibitory action to the Platelet Aggregation in Rabbits of ADP induction.From Radix Isatidis, get uridnine, hypoxanthine, pyrimidine, salicylic acid etc. the Platelet Aggregation in Rabbits of ATP induction is also all showed to certain inhibition activity, when 0.21mg/kg concentration, its suppression ratio is respectively 18.2%, 24.2%, 10.8% and 20%.Detoxication: for dog, Radix Isatidis, Rhizoma Coptidis powder and Rhizoma et radix veratri (Radix Rhizoma Veratri), with clothes (each 2.0g/kg), can be separated Rhizoma et radix veratri (Radix Rhizoma Veratri) poison, reduces mortality rate; If use again it after veratrum poisoning, invalid; The alone Radix Isatidis powder of difference or Rhizoma Coptidis powder, effect is also bad.< < book on Chinese herbal medicine is stated > >: hardship, and cold, nontoxic.< < book on Chinese herbal medicine is just read > >: enter liver, stomach blood system.The herbal > > of < < China: return liver; Stomach warp.There is heat clearing away, removing toxic substances, removing heat from blood, sore-throat relieving effect.Treatment maculae caused by violent heat pathogen; High heat headache; Major part pestilence; Crimson tongue is purple dark, scarlet fever; Erysipelas; Mumps; Sore throat; Skin ulcer is swollen, carbuncle; Chickenpox; Measles; Hepatitis; Influenza, epidemic encephalitis, encephalitis b, pneumonia, coma is told nosebleed, pharyngeal swelling, acute catarrhal conjunctivitis, skin ulcer rash; Can prevent and treat epidemic encephalitis type B, acute, chronic hepatitis, mumps, osteomyelitis.
Rhizoma Chuanxiong: ligustrazine energy coronary artery dilator, increase coronary artery blood flow, improve myocardium blood oxygen supply, and reduce myocardium oxygen consumption; The expansible cerebrovascular of ligustrazine, reduces vascular resistance, significantly increases brain and LBF amount, improves microcirculation; Can reduce surface activity of blood platelet, suppress platelet aggregation, the formation of pre-preventing thrombosis; The low dose of promotion of neutral compound of contained ferulic acid, heavy dose of uterine smooth muscle that suppresses; Water decoction has sedation to animal central nervous system, and has obvious and lasting hypotensive effect; Can accelerate the to fracture absorption of local hematoma, promotes callus formation; There is the effect of vitamin antagonist E shortage; Can suppress multiple bacillus; There are antihistaminic and choleretic effect.
Meropodium pearl: expelling wind and activating blood circulation, eliminating stasis to stop pain, antiinflammatory.Cure mainly rheumatic ostalgia, traumatic injury, nephroptosis, nephritis etc.
Parthenocissus: sweet, puckery, temperature.Function cures mainly: dispelling wind and removing obstruction in the collateral, promoting blood circulation and detoxication.For rheumatic arthritis; Traumatic injury is controlled in external, carbuncle furuncle and phyma poison.
Pericarpium Citri junoris: warm in nature, sweet-bitter flavor is nontoxic.Enter spleen, lung two warps.Function cures mainly: regulate the flow of vital energy, reduce phlegm, spleen invigorating, intestinal stasis relieving.The cough that cures cold, inappetence, chest and abdomen swelling and pain, borborygmus are just rushed down, acute mastitis.
Bodhi is fragrant: pungent, sweet, flat.Function cures mainly: enriching yin and nourishing kidney, suppressing the hyperactive liver improving eyesight, reducing swelling and alleviating pain.Cure cold, dizziness headache, hypertension, anemia, chronic enterogastritis, menoxenia, mastitis, the diseases such as sore.
Radix Glycyrrhizae: property is flat, and sweet in the mouth, returns 12 warps.Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, the anxious pain of extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strongly have removing toxic substances, eliminate the phlegm, pain relieving, spasmolytic be so that the pharmacological action such as anticancer, Radix Glycyrrhizae has blood fat reducing, antioxidative effect.
Radix Et Caulis Acanthopanacis Senticosi: acrid in the mouth, micro-hardship, slightly warm in nature.Return spleen, kidney, heart channel.Modern medicine studies have shown that effect feature and the Radix Ginseng of Radix Et Caulis Acanthopanacis Senticosi is basic identical, has the body of adjusting disorderly, makes it to be tending towards normal function.There is good antifatigue effect, remarkable compared with Radix Ginseng, and can significantly improve hypoxia-bearing capability.The functions such as invigorating middle warmer, benefit essence, strong will, wind-damp dispelling, strengthening bone and muscle, blood circulation and promoting silt, stomach invigorating diuresis.Take for a long time " make light of one's life by commiting suicide and endure hardships ".Radix Et Caulis Acanthopanacis Senticosi contains noticeable composition---eleutheroside, and it can stimulate mind & body vigor.Numerous scientific publications about Radix Et Caulis Acanthopanacis Senticosi have proved its antifatigue effect, strengthen endurance and ability, increase alertness and learning capacity.Numerous usages have all obtained confirmation in human experimentation.Radix Et Caulis Acanthopanacis Senticosi is rehabilitation after being ill, bears too much pressure or anxiety, works excessive, and chronic disease causes weakly crowd and those need to reach very welcome self-medication medicine in the people on physiology and psychological performance peak.At present there is equally the report of considerable quantity to point out that it has support immune system, recover improper hypotension, improve blood circulation, make disorderly glycolipid metabolism normalization, liver, testis, the anabolic effect of bone density and other vitals.Radix Et Caulis Acanthopanacis Senticosi extract shows can irritation cell immunity.Research finds that it can stimulate T-cell to produce, particularly assistant's cell.Therefore Radix Et Caulis Acanthopanacis Senticosi is used to panimmunity relevant disease.Radix Et Caulis Acanthopanacis Senticosi polysaccharide also has strong inhibitory action to the in-vitro multiplication of mice S180, human leukaemia K562 cell, and Radix Et Caulis Acanthopanacis Senticosi extract is containing multiple glycoside and Radix Et Caulis Acanthopanacis Senticosi polysaccharide, have improve immunity of organisms, leukocyte increasing, raising body to anoxia, radiation, stress, the adaptive capacity of the non-specific injury such as tired, poisoning.Tumor is had to obvious inhibitory action, also can promote marrow hemopoietic stem cells to the differentiation of grain-mononuclear cell, leukocyte to be increased simultaneously.
Caulis Akebiae: bitter, be slightly cold.Enter heart channel, small intestine meridian, urinary bladder channel.There is clearing away heart-fire, diuresis, the effect of the stimulating milk secretion of stimulating the menstrual flow.For irritable feverish sensation in the chest, sore throat pharyngalgia, dark coloured urine, five types of stranguria, edema, whole body spasm and pain, amenorrhea breast is few.The puckery pain of pyretic stranguria, edema.This product energy inducing diuresis to remove edema, diarrhea is damp and hot, makes that damp and hot heresy is descending discharges from urine.Treatment damp-heat in the urinary bladder, oliguria with reddish urine, drenches the puckery pain of drop, the adapteds such as normal and Semen Plantaginis, Talcum; For edema, be equipped with Polyporus, Cortex Mori is equal to use.Aphtha of the mouth and tongue, vexed dark coloured urine.The fire of this product energy supernatant heart channel, under let out small intestinal heat.Often control flaming up of heart-fire, aphtha of the mouth and tongue, or intestinal and the diseases such as vexed dark coloured urine that cause under heart-fire moving downward, the adapteds such as many and Radix Rehmanniae, Radix Glycyrrhizae, Folium Bambusae.Amenorrhea breast is few.These product stimulating milk secretion of stimulating the menstrual flow.With controlling blood stasis amenorrhea, join Flos Carthami, Semen Persicae, Radix Salviae Miltiorrhizae and be equal to use; If deficient or obstructed with controlling milk, can be equal to use with Semen Vaccariae, Squama Manis; These product can also sharp blood vessels, get round by bribery, and join Ramulus Mori, Semen Coicis is equal to use, treats damp and hot arthralgia pain.
Rhizoma Cyperi: pungent micro-hardship is sweet, flat, enter liver, tri-jiao channel.Distending pain over the hypochondrium; Mammary swelling is educated; Hernia pain; Menoxenia; Gastral cavity abdomen feeling of fullness pain; Belch acid regurgitation, vomiting and nausea; Abdominal pain during menstruation; Bleeding not during menses; Frequent fetal movement.
Colla Corii Asini: sweet, flat.Return lung, liver, kidney channel.Function cures mainly: the YIN nourishing of enriching blood, moisturize hemostasis.For blood deficiency and yellow complexion, dizzy cardiopalmus, flesh flaccidity is unable, dysphoria and insomnia, stirring-up of pathogenic wind in the interior resulting from deficiency, xeropulmonary cough, chronic cough spitting of blood, haematemesis hematuria, the metrorrhagia of having blood in stool, vaginal bleeding during pregnancy.
Radix et Caulis Opuntiae Dillenii: hardship, cool.Function cures mainly: heat-clearing and toxic substances removing, dissipating blood stasis for subsidence of swelling, benefiting stomach and stopping pain, antitussive.For Stomach duodenum ulcer, acute dysentery, cough; Mumps is controlled in external, mastitis, carbuncle furuncle and phyma poison, venom, burn and scald.
Lagerstroemia indica L.: micro-hardship, puckery, flat.Function cures mainly: invigorates blood circulation, and hemostasis, removing toxic substances, detumescence.For various hemorrhage, fracture, mastitis, eczema, hepatitis, cirrhotic ascites.
Pericarpium Citri Reticulatae: warm in nature, acrid in the mouth, hardship; Return spleen, lung meridian, for diseases such as distension and fullness of the chest and abdomen.The pungent loose logical temperature of Pericarpium Citri tangerinae, fragrant odour, is longer than and regulates the flow of vital energy, can enter spleen lung, thus can go loose sluggishness of lung-QI, again can promoting the circulation of QI to alleviate the stagnation in middle-JIAO, for lung qi, gather around the diseases such as stagnant, chest and diaphragm feeling of fullness and stagnation of QI in spleen and stomach, distension and fullness in the abdomen, for retention of dampness in middle-JIAO, gastral cavity abdomen painful abdominal mass is swollen, have loose bowels in loose stool, and the disease such as abundant expectoration cough.Pericarpium Citri tangerinae dispelling the damp pathogen with bitter and warm drugs and can spleen invigorating circulation of qi promoting, therefore be usually used in the diseases such as retention of dampness in middle-JIAO, gastral cavity abdominal distention are vexed, loose stool greasy fur, can compatibility Rhizoma Atractylodis, Cortex Magnoliae Officinalis is with using.Be good at again drying dampness to eliminate phlegm, for controlling damp-phlegm, stop up the conventional key medicine of lung, abundant expectoration cough, for insufficiency of the spleen diet reduce, dyspepsia, and the disease such as nausea and vomiting.This product dampness and can spleen benefiting and stimulating the appetite, is applicable to the diseases such as weakness of the spleen and stomach, diet minimizing, dyspepsia, loose stool and diarrhea, the fit applications such as normal and Radix Ginseng, the Rhizoma Atractylodis Macrocephalae, Poria.Can spleen invigorating because of it, can regulate the flow of vital energy again, therefore often make as the assistant of Qi-tonifying drug, can make tonify without causing stagnation, prevent from stopping up and hold back the swollen effect of doing, in addition, Pericarpium Citri tangerinae again can with in, can control stomach-QI being unable to descend normally, nausea and vomiting.
Semen Euryales: sweet in the mouth, puckery, property is flat.Cure mainly rheumatic arthritis, back gonalgia.Invigorating the spleen and replenishing QI, the strong will of refreshing oneself, makes people's normal hearing and eyesight.It is not hungry that clothes of a specified duration are made light of one's life by commiting suicide people.Can also whet the appetite and help gas and the kidney invigorating, control frequency of micturition, seminal emission, purulent leukorrhea.Make powder edible, beneficial people.But the unsuitable polyphagia of children's, strengthening the spleen stomach, is not difficult to digestion.
Endothelium Corneum Gigeriae Galli: sweet, cold, return spleen, stomach, small intestinal, urinary bladder channel, for promoting digestion and invigorating the stomach, arresting seminal emission.Endothelium Corneum Gigeriae Galli is containing gastric hormone, keratin, aminoacid and micro-pepsin, amylase etc.After oral Endothelium Corneum Gigeriae Galli powder, the secretory volume of gastric juice, acidity and eupepsy all increase, and stomach motion is strengthened, emptying quickening.Its acid extraction liquid or decoct can accelerate to get rid of radiostrontium from urine.
Massa Medicata Fermentata: book on Chinese herbal medicine > > records according to < < the southern regions of the Yunnan Province, and Massa Medicata Fermentata can " be held up taste to enter diet, disappear and stop the food of gastric every place ".Massa Medicata Fermentata is containing volume yeast, and vitamin B group, also contains multiple vitamin B group, therefore Massa Medicata Fermentata has the effect of vitamin B group sample in cerevisin.As appetite stimulator, maintain normal stool function etc.
Fructus Crataegi: section is dried, putting uses force in pot fries to outer wrinkly face brown, inner yellowish-brown as degree greatly, spray clear water, and taking-up is dried, and is Fructus Crataegi (parched to brown).There is appetite-stimulating indigestion-relieving, change stagnant removing food stagnancy, the effect of promoting blood circulation to remove blood stasis, the circulation of qi promoting of reducing phlegm, meridian distribution of property and flavor, sour, sweet, slightly warm in nature.Main component is containing chlorogenic acid, caffeic acid, Crataegolic acid, neat chrysanthemum fruit acid, Quercetin, ursolic acid, oleanolic acid, hyperin, epicatechin etc.Oral Fructus Crataegi can increase digestive enzyme, promotes fatty decomposition and digestion, to because of eat meat or greasy too much due to distension and fullness in the abdomen, belch, anorexia, stomachache, diarrhoea person, curative effect is especially good.In addition, modern medicines tests shows, Fructus Crataegi has the slow and lasting effect reducing blood pressure, and also can reduce cholesterol and triglyceride, atherosclerosis, but also can diastole coronary artery, increase myocardial contraction, to arrhythmia.Therefore, be conducive to prevent and treat hypertension, hyperlipidemia, arteriosclerosis and coronary heart disease.
Medicine of the present invention also comprises: Formica fusca, Radix Bupleuri, Ganoderma and Radix Rhodiolae.
Formica fusca: salty in the mouth; Acid; Property is put down.Return liver; Kidney channel.Function cures mainly: the kidney invigorating and essence nourishing; Dredge the meridian passage; Removing toxic substances and promoting subsidence of swelling.The main dizzy tinnitus of suffering from a deficiency of the kidney; Insomnia and dreamful sleep; Impotence and seminal emission; Rheumatic arthralgia; Apoplectic hemiplegia 6; Numb hand and foot; Lupus erythematosus; Scleroderma; Dermatomyositis; Carbuncle furuncle; Venom.
Radix Bupleuri: clearind deficient heat Chinese medicine, for cold, fever, alternate attack of chill and fever, malaria, stagnation of QI due to depression of the liver, sternal rib pain, proctoptosis, uterus come off, menoxenia.Radix Bupleuri begins to be loaded in < < Sheng Nong's herbal classic > >, classifies as top grade.Promote immunity function, effective ingredient: Bupleurum chinense polysaccharide.Effect: phagocytic function strengthens, Natural killer activity strengthens, and improves special viral antibody titre, improves lymphocyte and turns core rate, improves skin delayed hypersensitivity reaction.Anti-liver injury, injection of Radix Bupleuri (concentration 1: a 1) 1 ml/ subcutaneous injection can significantly reduce the rat blood serum GPT rising that carbon tetrachloride causes for continuous 5 days, hepatocellular degeneration and necrosis also obviously alleviate, and in hepatocyte, glycogen and rna content also approach normal.
Ganoderma: property is sweet, flat.GUIXIN, lung, liver, kidney channel.Cure mainly asthenia, cough, asthma, insomnia, dyspepsia, malignant tumor etc.Animal pharmacology shows experiment: Ganoderma has inhibitory action to nervous system, and blood circulation has blood pressure lowering and strengthens the effect of cardiac contractile force, and respiratory system is had to phlegm-dispelling functions, in addition, also has hepatoprotective, improves immunologic function, antibacterially waits effect.
Radix Rhodiolae: sweet, puckery, cold.Function cures mainly: clearing away lung-heat to relieve cough, hemostasis, leukorrhagia stopping.For cough due to lung-heat, spitting of blood, leucorrhea; Traumatic injury is controlled in external, burn and scald.QI invigorating lung heat clearing; Fructus Alpiniae Oxyphyllae is nourished heart; Hemostasis with astringents; Dissipating blood stasis for subsidence of swelling.Main deficiency of vital energy and physically weak; Fear of cold after being ill; Shortness of breath and fatigue; Cough due to lung-heat; Spitting of blood; Leucorrhea diarrhoea; Traumatic injury; Burn and scald; Neurosis; Altitude sickness.
Embodiment 1 powder 1
The embodiment of the present invention 1 provides a kind of medicine that is used for the treatment of mammitis of cow, medicine is comprised of the raw medicinal material of following parts by weight: the Radix Astragali 23 weight portions, Radix Codonopsis 15 weight portions, Phtheirospermum tenuisectum Bur.et Franch. 13 weight portions, Radix Angelicae Sinensis 15 weight portions, Herba Lactucae formosanae 20 weight portions, Rhizoma Et Radix Notopterygii 17 weight portions, Radix Isatidis 13 weight portions, Rhizoma Chuanxiong 17 weight portions, meropodium pearl 13 weight portions, parthenocissus 13 weight portions, Pericarpium Citri junoris 15 weight portions, fragrant 17 amounts part of bodhi, Radix Glycyrrhizae 16 weight portions, Radix Et Caulis Acanthopanacis Senticosi 15 weight portions, Caulis Akebiae 12 weight portions, Rhizoma Cyperi 13 weight portions, Colla Corii Asini 12 weight portions, Radix et Caulis Opuntiae Dillenii 13 weight portions, Lagerstroemia indica L. 15 weight portions, Pericarpium Citri Reticulatae 14 weight portions, Semen Euryales 13 weight portions, Endothelium Corneum Gigeriae Galli 13 weight portions, Massa Medicata Fermentata 18 weight portions and Fructus Crataegi 13 weight portions.
The embodiment of the present invention also provides a kind of preparation method that is used for the treatment of the medicine of mammitis of cow, and medicine is powder, and preparation method comprises the following steps:
The first step, is mixed in proportion all raw medicinal materials, is ground into 100 object powder, adds the water with respect to 5 times of mixture qualities, at the temperature of 90 ℃, decocts 30 minutes, and decoction liquor is filtered, and obtains the first filtrate and filtering residue;
Second step, the filtering residue that the first step is obtained adds the water with respect to 3 times of first step mixture qualities, at the temperature of 90 ℃, decocts 1 hour, and decoction liquor is filtered, and obtains the second filtrate;
The 3rd step, merges the first filtrate and the second filtrate, and concentrating under reduced pressure, except desolventizing, obtains and gets dry extract, and dry cream is put into spray dryer dry, guarantees that inlet temperature is at 190 ℃, and 80 ℃ of leaving air temps, are ground into 200 orders subsequently, obtain drug powder.
Embodiment 2 powders 2
The embodiment of the present invention provides a kind of medicine that is used for the treatment of mammitis of cow, medicine is comprised of the raw medicinal material of following parts by weight: the Radix Astragali 23 weight portions, Radix Codonopsis 15 weight portions, Phtheirospermum tenuisectum Bur.et Franch. 13 weight portions, Radix Angelicae Sinensis 15 weight portions, Herba Lactucae formosanae 20 weight portions, Rhizoma Et Radix Notopterygii 17 weight portions, Radix Isatidis 13 weight portions, Rhizoma Chuanxiong 17 weight portions, meropodium pearl 13 weight portions, parthenocissus 13 weight portions, Pericarpium Citri junoris 15 weight portions, fragrant 17 amounts part of bodhi, Radix Glycyrrhizae 16 weight portions, Radix Et Caulis Acanthopanacis Senticosi 15 weight portions, Caulis Akebiae 12 weight portions, Rhizoma Cyperi 13 weight portions, Colla Corii Asini 12 weight portions, Radix et Caulis Opuntiae Dillenii 13 weight portions, Lagerstroemia indica L. 15 weight portions, Pericarpium Citri Reticulatae 14 weight portions, Semen Euryales 13 weight portions, Endothelium Corneum Gigeriae Galli 13 weight portions, Massa Medicata Fermentata 18 weight portions, Fructus Crataegi 13 weight portions, Formica fusca 13 weight portions, Radix Bupleuri 17 weight portions, Ganoderma 12 weight portions and Radix Rhodiolae 13 weight portions.
The embodiment of the present invention also provides a kind of preparation method that is used for the treatment of the medicine of mammitis of cow, and medicine is powder, and preparation method comprises the following steps:
The first step, is mixed in proportion all raw medicinal materials, is ground into 150 object powder, adds the water with respect to 4 times of mixture qualities, at the temperature of 95 ℃, decocts 45 minutes, and decoction liquor is filtered, and obtains the first filtrate and filtering residue;
Second step, the filtering residue that the first step is obtained adds the water with respect to 2 times of first step mixture qualities, at the temperature of 95 ℃, decocts 45 minutes, and decoction liquor is filtered, and obtains the second filtrate;
The 3rd step, merges the first filtrate and the second filtrate, and concentrating under reduced pressure, except desolventizing, obtains and gets dry extract, and dry cream is put into spray dryer dry, guarantees that inlet temperature is at 180 ℃, and 70 ℃ of leaving air temps, are ground into 300 orders subsequently, obtain drug powder.
Embodiment 3 unguentum
The embodiment of the present invention provides a kind of medicine that is used for the treatment of mammitis of cow, medicine is comprised of the raw medicinal material of following parts by weight: the Radix Astragali 23 weight portions, Radix Codonopsis 15 weight portions, Phtheirospermum tenuisectum Bur.et Franch. 13 weight portions, Radix Angelicae Sinensis 15 weight portions, Herba Lactucae formosanae 20 weight portions, Rhizoma Et Radix Notopterygii 17 weight portions, Radix Isatidis 13 weight portions, Rhizoma Chuanxiong 17 weight portions, meropodium pearl 13 weight portions, parthenocissus 13 weight portions, Pericarpium Citri junoris 15 weight portions, fragrant 17 amounts part of bodhi, Radix Glycyrrhizae 16 weight portions, Radix Et Caulis Acanthopanacis Senticosi 15 weight portions, Caulis Akebiae 12 weight portions, Rhizoma Cyperi 13 weight portions, Colla Corii Asini 12 weight portions, Radix et Caulis Opuntiae Dillenii 13 weight portions, Lagerstroemia indica L. 15 weight portions, Pericarpium Citri Reticulatae 14 weight portions, Semen Euryales 13 weight portions, Endothelium Corneum Gigeriae Galli 13 weight portions, Massa Medicata Fermentata 18 weight portions, Fructus Crataegi 13 weight portions, Formica fusca 13 weight portions, Radix Bupleuri 17 weight portions, Ganoderma 12 weight portions and Radix Rhodiolae 13 weight portions.
The embodiment of the present invention also provides a kind of preparation method that is used for the treatment of the medicine of mammitis of cow, and medicine is unguentum, and preparation method comprises the following steps:
Take by weight all raw medicinal materials and soak 1.5 hours, be then placed in multi-function extractor, decoct for the first time amount of water and be 7 times of medical material, decoct, while being heated to 100 ℃, start timing, micro-boiling after 2 hours, filters and emits medicinal liquid from feed opening, puts in fluid reservoir; Decoct for the second time, amount of water is 7 times of amounts of medical material, is heated to 100 ℃, and micro-boiling after 2 hours extracted medicinal liquid out, merges with the medicinal liquid decocting for the first time; By merging in the decoction liquor suction concentrating under reduced pressure tank of latter 2 times, be decompressed to 0.05MPa, temperature remains on 70 ℃, and being concentrated into relative density is 1.20, and the extractum of temperature to 65 ℃ is cooling; The Margarita powder of getting extractum weight 10% adds in extractum, stirs, and tinning after ultraviolet radiation sterilizing.
Toxicity test
1, cumulative toxicity test report
Select 20 healthy mices, female, male each 10, the powder 1 of the embodiment of the present invention 1 of take is object, it is first phase that dosage designs every 5 days, each issue dosage is respectively 0.10LD50,0.15LD50,0.22LD50,0.34LD 50,0.50LD50, and the LD 50 female, male mice of this sample is 5000m part/k part BW (five dosage be 500,750,1100,1700,2500m part/k part BW).Within every 5 days, weigh once, adjust dosage, by 0.1ml/10 part BW per os gavage.After 20 days, animal occurs without death condition, off-test, and by ascending-dose, to tested material after 20 days, female, buck all occurs without death condition.The powder 2 of embodiment 2 of take is object, carries out according to the method described above toxicity test, and result is as identical in embodiment 1.
2, acute toxicity test
40 of application NIH mices, SPF level, male and female half and half, body weight 16～20g, carries out acute toxicity test.Mice is divided into two groups at random, and 20 every group, matched group and administration group, test front fasting 12 hours; The powder 1 of embodiments of the invention 1 preparation is dissolved in water, (concentration is 6.58g crude drug/ml, maximum concentration) gavage, gavage volume is that 5ml/kg(is that single-dose dosage is 32.9 crude drugs/kg), matched group gives equivalent normal saline, administration in a day 2 times, delivery time 6 hours, after administration, Continuous Observation is 14 days, and records toxic reaction and the death toll of mice.Experimental result shows: with matched group comparison, after administration, mice has no notable difference, experiment Continuous Observation 14 days, and mice overall health of patients, diet, drinking-water, body weight gain are all normal.The powder 1LD50>32.9 crude drug/kg of the mice oral administration gavage embodiment of the present invention 1, every day, maximum dosage-feeding was 65.8g crude drug/kg/ day.The clinical application amount of the powder 1 of the embodiment of the present invention 1 is 3g crude drug/day/head, and piglet body weight is in 6kg, and average dosage is 0.5g crude drug/kg/ day.By weighing machine: the dosis tolerata of the powder 1 of mice (average weight take 20g) the oral administration gavage embodiment of the present invention 1 is quantity 131 times.Therefore the acute toxicity of the powder 1 of the embodiment of the present invention 1 is low, clinical drug safety.The powder 2 of embodiment 2 of take is object, carries out according to the method described above toxicity test, and result is as identical in embodiment 1.
3, external acute skin irritation test
These product are according to 6.3 joints in Ministry of Public Health < < cosmetics health standard > > (2002) second portion " skin irritation/corrosion test ", male 4 of Japan large ear rabbit, body weight 2kg～3kg, the unguentum of getting the 0.5g embodiment of the present invention 3 directly spreads upon on the skin of animal left side (opposite side in contrast), adopt blocking test, 4 hours application time, after off-test, use the residual tested material of warm water washing, 1h after removing tested material, 24h, 48h and 72h observe respectively the dermoreaction of the tested district of animal and check plot, top average is " 0 ", judge that these product are to animal skin nonirritant.
4, external acute dermal toxicity test
These product are according to Ministry of Public Health < < cosmetics health standard > > (2002) second portion " acute dermal toxicity test " test method(s) of once limiting the quantity of, 20 of SD rats, male and female half and half, body weight 90g～180g, by the unguentum of the embodiment of the present invention 3, one time percutaneous is smeared 5000mg/kg body weight dosage, observe 15 days, do not find obvious poisoning symptom, nothing death, animal gross anatomy no abnormality seen, judges that these product are to the nontoxic level in the true border of rat acute percutaneous toxicity.
Clinical trial
(1) laboratory animal
160 milch cows that suffer from after diagnosing mastitis that laboratory animal provides for certain cattle farm.Tested on August 22,7 days to 2012 August in 2012, duration of test carries out daily feeding and management by cattle farm Routine Management way.
(2) test method
160 ill milch cows are divided into four experimental grouies at random, every group 40, four experimental grouies are used respectively the medicine (embodiment group 1) of the embodiment of the present invention 1, medicine (embodiment group 2), the medicine of embodiment 2 and the medicine of embodiment 3 of embodiment 2 are used (embodiment group 3) and conventional medicament (matched group) to treat jointly.Embodiment group 1 and embodiment group 2 are sneaked into powder 1 and powder 2 in water and are gavaged according to the part by weight of 1:5 respectively, every day twice, use continuously 8-15 days; In embodiment group 3, unguentum coordinates the powder 2 of embodiment 2 to use, and every day smeared twice by unguentum, uses continuously 8-15 days.
(3) criterion of therapeutical effect
Clinical trial of the present invention adopts California mastitis detection method (CMT) determination methods to provide curative effect determinate standard, and as shown in table 1, wherein effective percentage is the summation of " recovery from illness " and " improvement "; California mastitis detection method (CMT) determination methods and standard are as shown in table 2.
Table 1 clinical trial curative effect determinate standard of the present invention
Table 2 California mastitis detection method (CMT) determination methods and standard
(4) therapeutic effect
Result is as shown in table 1, and from therapeutic effect, adopting medicine of the present invention is more than 90% to the treated effect of mammitis of cow.
From the data of table 1, compare with matched group, use the Drug therapy mammitis of cow of the embodiment of the present invention 1 and embodiment 2 have advantages of evident in efficacy, cure rate is high, oral medicine of the present invention and unguentum the two to be used in conjunction with effect especially obvious; In long-term observation subsequently, find, the milch cow of embodiment group 1, embodiment group 2 and 3 recoveries from illness of embodiment group again sickness rate is starkly lower than the milch cow of matched group.
The foregoing is only preferred embodiment of the present invention, in order to limit the present invention, within the spirit and principles in the present invention not all, any modification of doing, be equal to replacement, improvement etc., within all should being included in protection scope of the present invention.
Claims (10)
1. the medicine that is used for the treatment of mammitis of cow, it is characterized in that, described medicine comprises following raw medicinal material: the Radix Astragali, Radix Codonopsis, Phtheirospermum tenuisectum Bur.et Franch., Radix Angelicae Sinensis, Herba Lactucae formosanae, Rhizoma Et Radix Notopterygii, Radix Isatidis, Rhizoma Chuanxiong, meropodium pearl, parthenocissus, Pericarpium Citri junoris, bodhi perfume, Radix Glycyrrhizae, Radix Et Caulis Acanthopanacis Senticosi, Caulis Akebiae, Rhizoma Cyperi, Colla Corii Asini, Radix et Caulis Opuntiae Dillenii, Lagerstroemia indica L., Pericarpium Citri Reticulatae, Semen Euryales, Endothelium Corneum Gigeriae Galli, Massa Medicata Fermentata and Fructus Crataegi.
2. the medicine that is used for the treatment of mammitis of cow according to claim 1, it is characterized in that, described medicine is comprised of the raw medicinal material of following parts by weight: Radix Astragali 15-30 weight portion, Radix Codonopsis 10-20 weight portion, Phtheirospermum tenuisectum Bur.et Franch. 10-15 weight portion, Radix Angelicae Sinensis 10-20 weight portion, Herba Lactucae formosanae 15-25 weight portion, Rhizoma Et Radix Notopterygii 10-25 weight portion, Radix Isatidis 10-16 weight portion, Rhizoma Chuanxiong 13-20 weight portion, meropodium pearl 10-15 weight portion, parthenocissus 10-15 weight portion, Pericarpium Citri junoris 10-20 weight portion, the fragrant 15-20 weight portion of bodhi, Radix Glycyrrhizae 15-20 weight portion, Radix Et Caulis Acanthopanacis Senticosi 10-20 weight portion, Caulis Akebiae 10-15 weight portion, Rhizoma Cyperi 10-15 weight portion, Colla Corii Asini 10-15 weight portion, Radix et Caulis Opuntiae Dillenii 10-15 weight portion, Lagerstroemia indica L. 10-20 weight portion, Pericarpium Citri Reticulatae 10-20 weight portion, Semen Euryales 10-15 weight portion, Endothelium Corneum Gigeriae Galli 10-15 weight portion, Massa Medicata Fermentata 15-20 weight portion and Fructus Crataegi 10-15 weight portion.
3. the medicine that is used for the treatment of mammitis of cow according to claim 1 and 2, it is characterized in that, described medicine is comprised of the raw medicinal material of following parts by weight: Radix Astragali 20-25 weight portion, Radix Codonopsis 13-18 weight portion, Phtheirospermum tenuisectum Bur.et Franch. 11-14 weight portion, Radix Angelicae Sinensis 12-17 weight portion, Herba Lactucae formosanae 18-22 weight portion, Rhizoma Et Radix Notopterygii 15-20 weight portion, Radix Isatidis 12-14 weight portion, Rhizoma Chuanxiong 15-18 weight portion, meropodium pearl 12-14 weight portion, parthenocissus 12-14 weight portion, Pericarpium Citri junoris 13-18 weight portion, the fragrant 16-18 amount part of bodhi, Radix Glycyrrhizae 15-18 weight portion, Radix Et Caulis Acanthopanacis Senticosi 13-18 weight portion, Caulis Akebiae 11-14 weight portion, Rhizoma Cyperi 12-14 weight portion, Colla Corii Asini 11-14 weight portion, Radix et Caulis Opuntiae Dillenii 11-14 weight portion, Lagerstroemia indica L. 12-18 weight portion, Pericarpium Citri Reticulatae 12-17 weight portion, Semen Euryales 11-14 weight portion, Endothelium Corneum Gigeriae Galli 11-14 weight portion, Massa Medicata Fermentata 17-19 weight portion and Fructus Crataegi 12-14 weight portion.
4. according to the medicine that is used for the treatment of mammitis of cow described in claim 1-3 any one, it is characterized in that, described medicine is comprised of the raw medicinal material of following parts by weight: the Radix Astragali 23 weight portions, Radix Codonopsis 15 weight portions, Phtheirospermum tenuisectum Bur.et Franch. 13 weight portions, Radix Angelicae Sinensis 15 weight portions, Herba Lactucae formosanae 20 weight portions, Rhizoma Et Radix Notopterygii 17 weight portions, Radix Isatidis 13 weight portions, Rhizoma Chuanxiong 17 weight portions, meropodium pearl 13 weight portions, parthenocissus 13 weight portions, Pericarpium Citri junoris 15 weight portions, fragrant 17 amounts part of bodhi, Radix Glycyrrhizae 16 weight portions, Radix Et Caulis Acanthopanacis Senticosi 15 weight portions, Caulis Akebiae 12 weight portions, Rhizoma Cyperi 13 weight portions, Colla Corii Asini 12 weight portions, Radix et Caulis Opuntiae Dillenii 13 weight portions, Lagerstroemia indica L. 15 weight portions, Pericarpium Citri Reticulatae 14 weight portions, Semen Euryales 13 weight portions, Endothelium Corneum Gigeriae Galli 13 weight portions, Massa Medicata Fermentata 18 weight portions and Fructus Crataegi 13 weight portions.
5. according to the medicine that is used for the treatment of mammitis of cow described in claim 1-4 any one, it is characterized in that, described medicine also comprises: Formica fusca, Radix Bupleuri, Ganoderma and Radix Rhodiolae.
6. according to the medicine that is used for the treatment of mammitis of cow described in claim 1-5 any one, it is characterized in that, described medicine is comprised of the raw medicinal material of following parts by weight: Radix Astragali 15-30 weight portion, Radix Codonopsis 10-20 weight portion, Phtheirospermum tenuisectum Bur.et Franch. 10-15 weight portion, Radix Angelicae Sinensis 10-20 weight portion, Herba Lactucae formosanae 15-25 weight portion, Rhizoma Et Radix Notopterygii 10-25 weight portion, Radix Isatidis 10-16 weight portion, Rhizoma Chuanxiong 13-20 weight portion, meropodium pearl 10-15 weight portion, parthenocissus 10-15 weight portion, Pericarpium Citri junoris 10-20 weight portion, the fragrant 15-20 weight portion of bodhi, Radix Glycyrrhizae 15-20 weight portion, Radix Et Caulis Acanthopanacis Senticosi 10-20 weight portion, Caulis Akebiae 10-15 weight portion, Rhizoma Cyperi 10-15 weight portion, Colla Corii Asini 10-15 weight portion, Radix et Caulis Opuntiae Dillenii 10-15 weight portion, Lagerstroemia indica L. 10-20 weight portion, Pericarpium Citri Reticulatae 10-20 weight portion, Semen Euryales 10-15 weight portion, Endothelium Corneum Gigeriae Galli 10-15 weight portion, Massa Medicata Fermentata 15-20 weight portion, Fructus Crataegi 10-15 weight portion, Formica fusca 10-16 weight portion, Radix Bupleuri 15-20 weight portion, Ganoderma 10-15 weight portion and Radix Rhodiolae 10-15 weight portion.
7. according to the medicine that is used for the treatment of mammitis of cow described in claim 1-6 any one, it is characterized in that, described medicine is comprised of the raw medicinal material of following parts by weight: Radix Astragali 20-25 weight portion, Radix Codonopsis 13-18 weight portion, Phtheirospermum tenuisectum Bur.et Franch. 11-14 weight portion, Radix Angelicae Sinensis 12-17 weight portion, Herba Lactucae formosanae 18-22 weight portion, Rhizoma Et Radix Notopterygii 15-20 weight portion, Radix Isatidis 12-14 weight portion, Rhizoma Chuanxiong 15-18 weight portion, meropodium pearl 12-14 weight portion, parthenocissus 12-14 weight portion, Pericarpium Citri junoris 13-18 weight portion, the fragrant 16-18 amount part of bodhi, Radix Glycyrrhizae 15-18 weight portion, Radix Et Caulis Acanthopanacis Senticosi 13-18 weight portion, Caulis Akebiae 11-14 weight portion, Rhizoma Cyperi 12-14 weight portion, Colla Corii Asini 11-14 weight portion, Radix et Caulis Opuntiae Dillenii 11-14 weight portion, Lagerstroemia indica L. 12-18 weight portion, Pericarpium Citri Reticulatae 12-17 weight portion, Semen Euryales 11-14 weight portion, Endothelium Corneum Gigeriae Galli 11-14 weight portion, Massa Medicata Fermentata 17-19 weight portion, Fructus Crataegi 12-14 weight portion, Formica fusca 12-14 weight portion, Radix Bupleuri 16-19 weight portion, Ganoderma 11-13 weight portion and Radix Rhodiolae 11-14 weight portion.
8. according to the medicine that is used for the treatment of mammitis of cow described in claim 1-7 any one, it is characterized in that, described medicine is comprised of the raw medicinal material of following parts by weight: the Radix Astragali 23 weight portions, Radix Codonopsis 15 weight portions, Phtheirospermum tenuisectum Bur.et Franch. 13 weight portions, Radix Angelicae Sinensis 15 weight portions, Herba Lactucae formosanae 20 weight portions, Rhizoma Et Radix Notopterygii 17 weight portions, Radix Isatidis 13 weight portions, Rhizoma Chuanxiong 17 weight portions, meropodium pearl 13 weight portions, parthenocissus 13 weight portions, Pericarpium Citri junoris 15 weight portions, fragrant 17 amounts part of bodhi, Radix Glycyrrhizae 16 weight portions, Radix Et Caulis Acanthopanacis Senticosi 15 weight portions, Caulis Akebiae 12 weight portions, Rhizoma Cyperi 13 weight portions, Colla Corii Asini 12 weight portions, Radix et Caulis Opuntiae Dillenii 13 weight portions, Lagerstroemia indica L. 15 weight portions, Pericarpium Citri Reticulatae 14 weight portions, Semen Euryales 13 weight portions, Endothelium Corneum Gigeriae Galli 13 weight portions, Massa Medicata Fermentata 18 weight portions, Fructus Crataegi 13 weight portions, Formica fusca 13 weight portions, Radix Bupleuri 17 weight portions, Ganoderma 12 weight portions and Radix Rhodiolae 13 weight portions.
9. a preparation method for the medicine that is used for the treatment of mammitis of cow as described in claim 1-8 any one, is characterized in that, described preparation method comprises the following steps:
The first step, is mixed in proportion all raw medicinal materials, is ground into 100 order～200 object powder, add the water with respect to 3～5 times of mixture qualities, at the temperature of 90 ℃～100 ℃, decoct 30 minutes～1 hour, decoction liquor is filtered, and obtains the first filtrate and filtering residue;
Second step, the filtering residue that the first step is obtained adds the water with respect to 1～3 times of first step mixture quality, at the temperature of 90 ℃～100 ℃, decocts 30 minutes～1 hour, and decoction liquor is filtered, and obtains the second filtrate;
The 3rd step, merges the first filtrate and the second filtrate, and concentrating under reduced pressure is except desolventizing, obtain and get dry extract, dry cream is put into spray dryer dry, guarantee that inlet temperature is at 170 ℃～190 ℃, 60 ℃～80 ℃ of leaving air temps, are ground into 200 order～400 orders subsequently, obtain drug powder.
10. a preparation method for the medicine that is used for the treatment of mammitis of cow as described in claim 1-8 any one, is characterized in that, described medicine is emulsifiable paste, and described preparation method comprises the following steps:
Take by weight all raw medicinal materials and soak 1-2 hour, be then placed in multi-function extractor, decoct for the first time amount of water and be the 5-10 of medical material doubly, decoct, while being heated to 100 ℃, start timing, micro-boiling after 2 hours, filters and emits medicinal liquid from feed opening, puts in fluid reservoir; Decoct for the second time, amount of water is that medical material 5-10 doubly measures, and is heated to 100 ℃, and micro-boiling after 2 hours extracted medicinal liquid out, merges with the medicinal liquid decocting for the first time; By merging in the decoction liquor suction concentrating under reduced pressure tank of latter 2 times, be decompressed to 0.03-0.08MPa, temperature remains on 60-80 ℃, and being concentrated into relative density is 1.20, and the extractum that temperature to 60 is ℃-70 ℃ is cooling; The Margarita powder of getting extractum weight 10% adds in extractum, stirs, and tinning after ultraviolet radiation sterilizing.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104304809A (en) * | 2014-11-09 | 2015-01-28 | 蒋法成 | Feed additive for cow during lactation period and application of feed additive |
| CN104642816A (en) * | 2015-03-20 | 2015-05-27 | 广州市番禺区大川饲料有限公司 | Feed preventing egg drop syndrome of laying duck |
| CN106720982A (en) * | 2016-11-28 | 2017-05-31 | 全椒凤巢植保专业合作社 | A kind for the treatment of method of milk goat mastitis |
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| CN101181011A (en) * | 2007-11-23 | 2008-05-21 | 金陵科技学院 | Chinese herbal medicine feedstuff additive-summer quiet powder and preparation method as well as application thereof |
| CN101554400A (en) * | 2008-04-09 | 2009-10-14 | 北京大北农动物保健科技有限责任公司 | Medicine for preventing and curing agalactia, lactation lack and mastitis of livestock and preparation method thereof |
| CN102488814A (en) * | 2011-12-22 | 2012-06-13 | 中国农业科学院北京畜牧兽医研究所 | Chinese medicinal composition for treating bovine mastitis |
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2013
- 2013-12-25 CN CN201310722875.8A patent/CN103656048B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101181011A (en) * | 2007-11-23 | 2008-05-21 | 金陵科技学院 | Chinese herbal medicine feedstuff additive-summer quiet powder and preparation method as well as application thereof |
| CN101554400A (en) * | 2008-04-09 | 2009-10-14 | 北京大北农动物保健科技有限责任公司 | Medicine for preventing and curing agalactia, lactation lack and mastitis of livestock and preparation method thereof |
| CN102488814A (en) * | 2011-12-22 | 2012-06-13 | 中国农业科学院北京畜牧兽医研究所 | Chinese medicinal composition for treating bovine mastitis |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104304809A (en) * | 2014-11-09 | 2015-01-28 | 蒋法成 | Feed additive for cow during lactation period and application of feed additive |
| CN104642816A (en) * | 2015-03-20 | 2015-05-27 | 广州市番禺区大川饲料有限公司 | Feed preventing egg drop syndrome of laying duck |
| CN106720982A (en) * | 2016-11-28 | 2017-05-31 | 全椒凤巢植保专业合作社 | A kind for the treatment of method of milk goat mastitis |
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| CN103656048B (en) | 2015-08-12 |
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