CN104324093A - Traditional Chinese medicine composition for treating hyperosteogeny and preparation method of traditional Chinese medicine composition - Google Patents

Traditional Chinese medicine composition for treating hyperosteogeny and preparation method of traditional Chinese medicine composition Download PDF

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CN104324093A
CN104324093A CN201410595372.3A CN201410595372A CN104324093A CN 104324093 A CN104324093 A CN 104324093A CN 201410595372 A CN201410595372 A CN 201410595372A CN 104324093 A CN104324093 A CN 104324093A
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chinese medicine
hyperosteogeny
medicine composition
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caulis
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陈国志
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陈国志
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Abstract

The invention relates to a traditional Chinese medicine composition for treating hyperosteogeny and a preparation method of the traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from the following raw materials: Chinese starjasmine stem, dentiferous dendropanax root and stem, futokadsura stem, euonymus fortunei, giantleaf ardisia rhizome, polygala fallax hemsl and perilla nankinensis decue. The traditional Chinese medicine composition disclosed by the invention has the effects of expelling wind and removing damness, activating meridian, promoting blood circulation and stopping pain and has good treatment effect on the hyperosteogeny.

Description

A kind of Chinese medicine composition for the treatment of hyperosteogeny and preparation method thereof
Technical field
The present invention relates to the field of Chinese medicines, be specifically related to a kind of Chinese medicine composition for the treatment of hyperosteogeny and preparation method thereof.
Background technology
Bone matrix hyperplasia is also called hyperplastic osteoarthritis, osteoarthritis etc., soft tissue degeneration, the degeneration such as cartilage, intervertebral disc, ligament owing to forming joint, joint margins forms bony spur, synovial membrane plumpness waits change, and occurs osteoclasia, causes insecondary hyperosteogeny, cause joint deformity, when being subject to abnormal load, cause arthralgia, a kind of disease of the symptoms such as limitation of activity.Hyperostosis constitutional estranged and Secondary cases two kinds.
The method of current treatment bone matrix hyperplasia has a lot, and person's limitation is all deposited in treatment: one, galvanoiontophoresis method.Galvanoiontophoresis method has given full play to the effect of medicine, but is liquid because importing medicine, volatile, and drug effect is not lasting, limits the therapeutic effect of the method.Two, ultraviolet therapy: its therapeutical effect is mainly manifested in the following aspects: (1) bactericidal action; (2) antiinflammation; (3) analgesic effect; (4) wound healing effect is promoted; (5) desensitization; (6) formation of vitamin D3 is promoted; (7) body's immunity etc. is reconciled.Three, western medicine.Current doctor trained in Western medicine there is no effective medicine to this disease, often adopts anti symptom treatment, as taken the medicine of some antipyretic-antalgics during pain; Numbness person can select vitamin B group class medicine; Arthroncus has hydrops, and person can give therapy such as local extraction hydrops or partial closure etc.But facts have proved that these Therapeutic Method are all undesirable, just take stopgap measures and do not effect a permanent cure, the state of an illness easily recurs.Four, operative treatment: operative treatment is not the first-selected therapy of hyperosteogeny.When select expectant treatment invalid and the state of an illness heavier, have a strong impact on minimal invasive treatment time, can operative treatment be considered.
Bone matrix hyperplasia belongs to the category of " arthromyodynia ", " rheumatism involving the bone " of the traditional Chinese medical science, and this disease blocks with wound, strain, wind-cold damp pathogen, congestion, phlegm resistance, caused by liver and kidney deficiency etc. are relevant.
Caused by liver and kidney deficiency: in other words, deficiency of the liver and kindey, unable protection bone marrow, bone marrow of supplementing nutrition, of long duration, joint, in active procedure repeatedly, gradually suffers damage and occurs too quickly too early degenerating.
Wound and strain: wound and strain causes the most concentrated stressed local joint generation QI and blood disorderly inverse, the serious muscle that causes damages bone injury, and blood flow does not follow Chang Dao and overflows that to form blood stasis outward in arteries and veins sluggish, cause joint skeleton structural damage, lose nourishing, the time one is of a specified duration, and degenerative disease just there will be.
Affection of exogenous wind-cold damp: refer to be affected by the cold, catch a cold or for a long time occupy humidity ground, paddle in spite of the rain.This certainly not causes the reason of uncle's Li hyperosteogeny.The sunny side room of building, in the north, is lived again by his family, moist, and at ordinary times he also exactissima diligentia is warming.
Phlegm resistance: general yang deficiency excessive phlegm, easily suffers from hyperosteogeny.And fat people has also increased the weight of the burden in joint, more easily cause local joint blood to transport not smooth, muscles and bones mistake has been supported, and then becomes numbness for a long time.
Chinese medicine is thought: kidney governing bones, liver governing tendons, and muscle invests bone.Old people fails due to hepatic and renal function, and suffering from a deficiency of the kidney can not main bone, and deficiency of the liver can not nourishing muscle and tendon, add the invasion and attack of wind-cold damp pathogen, or wound, cause qi-blood disharmony, in the course of time expectorant blood increases the weight of, and will form hyperosteogeny, thus produces the symptoms such as pain discomfort, numb limbs and tense tendons, moving obstacle.Therefore, the Chinese medicine of hyperosteogeny generally adopts invigorating the liver and kidney, bone and muscle strengthening, expelling wind and removing dampness, the Therapeutic Principle invigorated blood circulation.
Summary of the invention
The object of this invention is to provide a kind of Chinese medicine composition for the treatment of hyperosteogeny;
Another object of the present invention is to provide a kind of Chinese medicine composition preparation method for the treatment of hyperosteogeny.
The object of the invention is by following technical scheme realize:
The Chinese medicine composition for the treatment of hyperosteogeny of the present invention, it is prepared from by the raw material comprising following weight portion:
Caulis Trachelospermi 6-20 part, Radix Dendropanacis 25-50 part, Caulis Piperis Kadsurae 6-20 part, Caulis Seu Folium Euonymi Fortunei 6-20 part, Rhizoma Ardisiae Gigantifoliae 15-40 part, yellow fluid Thalictrum omeiense W. T. Wang et S. H. Wang 20-40 part, Folium Perillae 5-20 part.
Preferably, be prepared from by the raw material comprising following weight portion:
Caulis Trachelospermi 10-15 part, Radix Dendropanacis 30-40 part, Caulis Piperis Kadsurae 10-15 part, Caulis Seu Folium Euonymi Fortunei 10-15 part, Rhizoma Ardisiae Gigantifoliae 20-30 part, yellow fluid Thalictrum omeiense W. T. Wang et S. H. Wang 25-35 part, Folium Perillae 10-15 part.
More excellent, be prepared from by the raw material comprising following weight portion:
Caulis Trachelospermi 12 parts, Radix Dendropanacis 35 parts, Caulis Piperis Kadsurae 12 parts, Caulis Seu Folium Euonymi Fortunei 12 parts, Rhizoma Ardisiae Gigantifoliae 25 parts, yellow fluid Thalictrum omeiense W. T. Wang et S. H. Wang 30 parts, Folium Perillae 12 parts.
Below the crude drug source of Chinese medicine composition of the present invention:
Caulis Trachelospermi is the dry zone leaf rattan of apocynaceae plant trachelospermum jasminoide Trachelospermum jasminoides (Lindl.) Lem..Hardship, is slightly cold.GUIXIN, liver, kidney channel.Dispelling wind and removing obstruction in the collateral, removing heat from blood is subsided a swelling.For beriberoid pyretic arthralgia, the contracture of muscle arteries and veins, soreness of waist and knee joint, sore throat, carbuncle, injury from falling down.
Radix Dendropanacis, is Araliaceae tree ginseng platymiscium tree ginseng Dendropanax chevalieri (Vig.) Merr. et Chun, is used as medicine with root or branch and leaf.Sweet, temperature.Expelling wind and removing dampness, relaxing muscles and tendons to promote blood circulation.For migraine, brachial plexus neuritis, rheumatic arthritis, rheumatoid arthritis, lumbar muscle strain, chronic lambago and skelalgia, hemiplegia, traumatic injury, bruise; External is controlled on cutter hemorrhage.
Caulis Piperis Kadsurae is the dry rattan of Piperaceae plant Radix seu Caulis fici Martinii Piper kadsura (Choisy) Ohwi.Pungent, bitter, tepor.Return Liver Channel.Wind-damp dispelling, the meridian dredging, stopping numbness pain.For anemofrigid-damp arthralgia, arthrodynia of extremities, the contracture of muscle arteries and veins, joint stuffiness.
Caulis Seu Folium Euonymi Fortunei, Celastraceae burning buss Caulis Seu Folium Euonymi Fortunei Euonymus fortunei (Turcz.) Hand.-Mazz., is used as medicine with stem, leaf.Bitter, sweet, temperature.Dissipating blood stasis stops blooding, relaxing muscles and tendons and activating QI and blood in the collateral.For spitting of blood, menoxenia, dysfunctional uterine hemorrhage, rheumatic arthralgia; Traumatic injury is controlled in external, fracture, wound hemorrhage.
Rhizoma Ardisiae Gigantifoliae is the dry root of Myrsinacea plant Rhizoma Ardisiae Gigantifoliae Ardisia gigantifolia stapf.Bitter, micro-pungent, temperature.To dispel the wind removing dampness, reducing swelling and alleviating pain.Root: for rheumatic arthritis, lumbago and skelalgia, treating swelling and pain by traumatic injury; Leaf: external is controlled and sprained, carbuncle furuncle and phyma poison, chronic ulcer.
Yellow fluid Thalictrum omeiense W. T. Wang et S. H. Wang, Ranunculaceae thalictrum spp high eyebrow Thalictrum aquilegifolium L. var. sibiricum Regel Thalictrum omeiense W. T. Wang et S. H. Wang, with all herbal medicine.Bitter, puckery, cold.Heat clearing away, dampness, dysentery relieving.For jaundice due to damp-heat, stomachache dysentery, malaria cold and heat, conjunctival congestion and swelling pain.
Folium Perillae, the band branch tender leaf of Labiatae Perilla plant Folium Perillae Perilla frutescens (L.) Britt..Pungent, temperature.Expelling cold and relieving exterior syndrome, regulating the flow of QI to ease the stomach.For anemofrigid cold, headache, cough, distension and fullness of the chest and abdomen.
Another aspect of the present invention there is provided the preparation method of the active component of Chinese medicine composition of the present invention, and the method adopts the ethanol extraction of water extraction or 40-80% concentration expressed in percentage by volume to be prepared from.Concrete preparation method is as follows:
Scheme one: get whole 7 taste medical materials, extracting in water 2-3 time after mixing, each amount of water is equivalent to the 6-12 of medical material gross weight doubly, each extraction time is 1-3 hour, merge extractive liquid, filters, when filtrate is concentrated into 70-80 DEG C, relative density is the clear paste of 1.15-1.20, obtains active component.
Scheme two: get whole 7 taste medical materials, uses 40-80% alcohol reflux 2-3 time after mixing, and each ethanol consumption is 4-10 times of medical material total amount, extraction time is 1-4 hour, merge extractive liquid, filters, when filtrate is concentrated into 70-80 DEG C, relative density is the clear paste of 1.15-1.20, obtains active component.
Scheme three: get whole 7 taste medical materials, extracting in water 2-3 time after mixing, each amount of water is equivalent to the 6-12 of medical material gross weight doubly, each extraction time is 1-3 hour, merge extractive liquid, filters, and when filtrate is concentrated into 70-80 DEG C, relative density is the clear paste of 1.15-1.20, add ethanol, make alcohol content be 40-70%, leave standstill 12-24 hour, filter, when filtrate is concentrated into 70-80 DEG C, relative density is the extractum of 1.10-1.25, obtains active component.
The Chinese medicine for the treatment of hyperosteogeny of the present invention, with pharmaceutically acceptable carrier combination, can also make various oral formulations, as tablet, capsule, oral liquid, syrup, mixture etc.
Pharmaceutically acceptable carrier of the present invention includes but not limited to following:
Oral formulations:
Diluent: starch, Icing Sugar, lactose, dextrin, microcrystalline Cellulose, inorganic salt, sugar alcohols etc.
Wetting agent and binding agent: purified water, ethanol, gelatin, Polyethylene Glycol, cellulose derivative etc.
Disintegrating agent: starch, carboxymethyl starch sodium, cellulose derivative, polyvinylpolypyrrolidone etc.
Lubricant: magnesium stearate, micropowder silica gel, Pulvis Talci, Polyethylene Glycol etc.
Cosolvent: water, ethanol, glycerol, propylene glycol, liquid Paraffin, plant wet goods.
Correctives: sucrose, monosaccharide, aromatic etc.
Antiseptic: benzoic acid, sorbic acid, methyl ester, ethyl ester, propyl ester etc.
Method 1: tablet
Get one of scheme one to scheme three gained active component, add tablet and commonly use adjuvant, production method is prepared into Tablets routinely.
Above-mentioned tablet is commonly used adjuvant and is comprised one of diluent, wetting agent, binding agent, disintegrating agent, lubricant or whole.
Method 2: capsule
Get one of scheme one to scheme three gained active component, add capsule and commonly use adjuvant, production method is prepared into capsule of the present invention routinely.
Above-mentioned capsule is commonly used adjuvant and is comprised one of diluent, wetting agent, binding agent, disintegrating agent, lubricant or whole.
Method 3: syrup
Get one of scheme one to scheme three gained active component, add syrup and commonly use adjuvant, production method is prepared into syrup of the present invention routinely.
Above-mentioned syrup is commonly used adjuvant and is comprised one of correctives, antiseptic, cosolvent or whole.
Method 4: mixture
Get one of scheme one to scheme three gained active component, add mixture and commonly use adjuvant, production method is prepared into mixture of the present invention routinely.
Above-mentioned mixture is commonly used adjuvant and is comprised one of correctives, antiseptic or whole.
Method 5: oral liquid
Get one of scheme one to scheme three gained active component, dissolve after-purification, concentrate, add oral liquid and commonly use adjuvant, production method is prepared into oral liquid of the present invention routinely.
Above-mentioned oral liquid is commonly used adjuvant and is comprised one of correctives, antiseptic, cosolvent or whole.
Multiple formulations with reference to modern pharmacological research achievement, through test for many years, is screened, be have found the Chinese medicine formula effectively treating hyperosteogeny by the applicant on the basis of research tradition tcm syndrome differentiation and treatment.
Chinese medicine composition effective ingredient disclosed in this invention is prepared from by Caulis Trachelospermi, Radix Dendropanacis, Caulis Piperis Kadsurae, Caulis Seu Folium Euonymi Fortunei, Rhizoma Ardisiae Gigantifoliae, yellow fluid Thalictrum omeiense W. T. Wang et S. H. Wang, Folium Perillae.Caulis Trachelospermi dispelling wind and removing obstruction in the collateral in side, removing heat from blood is subsided a swelling; Radix Dendropanacis expelling wind and removing dampness, relaxing muscles and tendons to promote blood circulation; The pain relieving of Caulis Piperis Kadsurae dispelling wind and removing obstruction in the collateral; Caulis Seu Folium Euonymi Fortunei relaxing muscles and tendons and activating QI and blood in the collateral; Rhizoma Ardisiae Gigantifoliae dispels the wind removing dampness, reducing swelling and alleviating pain; Yellow fluid Thalictrum omeiense W. T. Wang et S. H. Wang heat clearing and damp drying; Folium Perillae dispersing wind-cold.Full side works in coordination with mutually, has expelling wind and removing dampness, relaxes through the effect of dredging collateral, promoting blood circulation and stopping pain, have good therapeutic effect to hyperosteogeny.
  
A kind of Chinese medicine composition for the treatment of hyperosteogeny provided by the invention has the following advantages:
1, composite preparation provided by the invention is safe and effective, has expelling wind and removing dampness, relaxes through the effect of dredging collateral, promoting blood circulation and stopping pain, have good therapeutic effect to hyperosteogeny.
2, prove through clinical trial, patient is after traditional Chinese medicine composition for treating of the present invention, and the clinical symptoms of hyperosteogeny patient has clear improvement, and total effective rate reaches 91.1%.
3, Chinese medicinal composition preparation provided by the invention, scientific formulation is reasonable, and technique is simple, and mouthfeel is good, and cost is low.
Detailed description of the invention
The present invention is further illustrated below by embodiment.It should be understood that embodiments of the invention are for illustration of the present invention instead of limitation of the present invention.Essence according to the present invention all belongs to the scope of protection of present invention to the simple modifications that the present invention carries out.Except as otherwise noted, the percent of the amount of alcohol in the present invention is percentage by volume, and v/v represents the volume ratio of solution.
Embodiment 1 oral liquid
Take Caulis Trachelospermi 0.6kg, Radix Dendropanacis 2.5kg, Caulis Piperis Kadsurae 0.6kg, Caulis Seu Folium Euonymi Fortunei 0.6kg, Rhizoma Ardisiae Gigantifoliae 1.5kg, yellow fluid Thalictrum omeiense W. T. Wang et S. H. Wang 2kg, Folium Perillae 0.5kg.Get 7 taste medical materials, extracting in water 2 times, twice amount of water is respectively 10 times, 8 times of medical material gross weight, the extracted twice time is respectively 2 hours, 1 hour, merge extractive liquid, filters, when filtrate is concentrated into 80 DEG C, relative density is the extractum of 1.10, in extractum, add adjuvant mannitol, sorbic acid, water stirs, subpackage, obtained oral liquid.
Embodiment 2 tablet
Take Caulis Trachelospermi 2kg, Radix Dendropanacis 5kg, Caulis Piperis Kadsurae 2kg, Caulis Seu Folium Euonymi Fortunei 2kg, Rhizoma Ardisiae Gigantifoliae 4kg, yellow fluid Thalictrum omeiense W. T. Wang et S. H. Wang 4kg, Folium Perillae 2kg.Get 7 taste medical materials, with 40% alcohol reflux 3 times, each ethanol consumption is respectively 10 times, 8 times, 4 times of medical material total amount, 3 hours, 2 hours, 1 hour respectively extraction time, merge extractive liquid, filters, and when filtrate concentrates 60 DEG C, relative density is the extractum of 1.25, add supplementary product starch, ethanol, Pulvis Talci, obtained tablet.
Embodiment 3 granule
Take Caulis Trachelospermi 1kg, Radix Dendropanacis 3kg, Caulis Piperis Kadsurae 1kg, Caulis Seu Folium Euonymi Fortunei 1kg, Rhizoma Ardisiae Gigantifoliae 2kg, yellow fluid Thalictrum omeiense W. T. Wang et S. H. Wang 2.5kg, Folium Perillae 1kg.Get 7 taste medical materials, extracting in water 3 times, three amount of water are equivalent to 12 times, 8 times, 6 times of medical material gross weight respectively, 3 hours, 2 hours, 1 hour respectively each extraction time, merge extractive liquid, filters, when filtrate is concentrated into 70 DEG C, relative density is the clear paste of 1.20, add ethanol, make alcohol content be 40%, leave standstill 24 hours, filter, it is the extractum of 1.10 that filtrate is concentrated into relative density when filtrate is concentrated into 70 DEG C, adds starch, dextrin, granulates, dry, granulate and get final product.
Embodiment 4 capsule
Take Caulis Trachelospermi 1.5kg, Radix Dendropanacis 4kg, Caulis Piperis Kadsurae 1.5kg, Caulis Seu Folium Euonymi Fortunei 1.5kg, Rhizoma Ardisiae Gigantifoliae 3kg, yellow fluid Thalictrum omeiense W. T. Wang et S. H. Wang 3.5kg, Folium Perillae 1.5kg.Get 7 taste medical materials, with alcohol reflux 2 times, each concentration of alcohol is respectively 80%, 60%, each ethanol consumption is respectively 10 times, 8 times of medical material total amount, and extraction time is respectively 4 hours, 3 hours, merge extractive liquid, filter, when filtrate is concentrated into 80 DEG C, relative density is the extractum of 1.10, adds supplementary product starch, ethanol, dextrin, magnesium stearate, make capsule according to a conventional method in extractum.
Embodiment 5 tablet
Take Caulis Trachelospermi 1.2kg, Radix Dendropanacis 3.5kg, Caulis Piperis Kadsurae 1.2kg, Caulis Seu Folium Euonymi Fortunei 1.2kg, Rhizoma Ardisiae Gigantifoliae 2.5kg, yellow fluid Thalictrum omeiense W. T. Wang et S. H. Wang 3kg, Folium Perillae 1.2kg.Get 7 taste medical materials, three amount of water are respectively 12 times, 8 times, 6 times of medical material gross weight, three extraction times are respectively 3 hours, 2 hours, 1 hour, merge extractive liquid, filter, when filtrate is concentrated into 70 DEG C, relative density is the clear paste of 1.25, adds supplementary product starch, ethanol, Pulvis Talci, obtained tablet.
Embodiment 6 granule
Take Caulis Trachelospermi 1.5kg, Radix Dendropanacis 3kg, Caulis Piperis Kadsurae 1kg, Caulis Seu Folium Euonymi Fortunei 1.5kg, Rhizoma Ardisiae Gigantifoliae 3kg, yellow fluid Thalictrum omeiense W. T. Wang et S. H. Wang 2kg, Folium Perillae 1kg.Get 7 taste medical materials, each amount of water is equivalent to 12 times, 10 times of medical material gross weight respectively, and each extraction time is respectively 3 hours, 2 hours, merge extractive liquid, filter, it is the clear paste of 1.05 that filtrate is concentrated into relative density at 80 DEG C, adds ethanol, alcohol content is made to be 70%, leave standstill 12 hours, filter, when filtrate is concentrated into 70 DEG C, relative density is the extractum of 1.25, add starch, dextrin, granulate, dry, granulate and get final product.
Embodiment 7 syrup
Take Caulis Trachelospermi 1kg, Radix Dendropanacis 2.5kg, Caulis Piperis Kadsurae 1.5kg, Caulis Seu Folium Euonymi Fortunei 1kg, Rhizoma Ardisiae Gigantifoliae 2kg, yellow fluid Thalictrum omeiense W. T. Wang et S. H. Wang 3.5kg, Folium Perillae 1.5kg.Get 7 taste medical materials, twice amount of water is respectively 10 times, 8 times of medical material gross weight, and the extracted twice time is respectively 2 hours, 1 hour, merge extractive liquid, filters, and when filtrate is concentrated into 80 DEG C, relative density is the extractum of 1.10.In extractum, add syrup adjuvant sucrose, sorbic acid, water stirs, obtained syrup.
Embodiment 8 mixture
Take Caulis Trachelospermi 1.4kg, Radix Dendropanacis 4kg, Caulis Piperis Kadsurae 0.8kg, Caulis Seu Folium Euonymi Fortunei 0.7kg, Rhizoma Ardisiae Gigantifoliae 2.3kg, yellow fluid Thalictrum omeiense W. T. Wang et S. H. Wang 3.2kg, Folium Perillae 1.3kg.Get 7 taste medical materials, three amount of water are equivalent to 12 times, 8 times, 6 times of medical material gross weight respectively, 3 hours, 2 hours, 1 hour respectively each extraction time, merge extractive liquid, filter, filtrate is concentrated into 3 times that gross weight is medical material gross weight, fill, add mixture adjuvant sucrose, ethyl ester, water, sorbic acid stir, obtained mixture.
Embodiment 9 powder
Take Caulis Trachelospermi 1.4kg, Radix Dendropanacis 4kg, Caulis Piperis Kadsurae 0.8kg, Caulis Seu Folium Euonymi Fortunei 0.7kg, Rhizoma Ardisiae Gigantifoliae 2.3kg, yellow fluid Thalictrum omeiense W. T. Wang et S. H. Wang 3.2kg, Folium Perillae 1.3kg.Get 7 taste medical materials, pulverize, sieve, obtained powder.
  
clinical trial
one, to the clinical observation of hyperosteogeny disease
1 physical data
Totally 90 routine patients, wherein man 42 example, female 48 example.Max age 67 years old, minimal ages 35 years old, 47.4 years old mean age.The longest course of disease 11 years, the shortest course of disease 4 months, average course of disease 4.5 years.Clinical manifestation: all there is chronic pain at most of morbidity position, part hyperosteogeny patient, has the radiated pain of dorsocephalad, and waits abnormal sensory with cold and numbness, small part hyperosteogeny patient has autonomic nervous dysfunction, as the symptom such as nauseating, dizziness, tinnitus.Some patients painful area is also had all to have obvious muscular spasm or muscle tonus in addition.
2 diagnosis basis
Judge according to the diagnosis basis of rheumatism involving the bone in " Chinese medical disease Standardization of diagnosis and curative effect ".1. suffering oppression and irritation appears in diseased region, and wherein cervical spondylosis patient has long-term neck shoulder and back ache, dizziness headache, the numb or symptom such as unfavorable of changing one's position of both hands.2. x line to take the photograph in sheet visible cervical vertebra just, lateral projection, left and right oblique film, cervical vertebrae physiological is bending to be straightened or instead to bend, prolapse of lumbar intervertebral disc, intervertebral foramina stenosis, vertebral body hyperosteogeny; The positive side of knee joint is visible: proximal ends of tibia, and the interior lateral condyle hyperosteogeny of distal part of femur is formed, lower edge, spinous process of tibia on patella, and calcaneal tuberosity bony spur is formed.Patient diagnosis result: knee joint hyperosteogeny 15 example, lumbar vertebra hyperosteogeny 28 example, hyperosteogeny of cervical vertebra 47 example.
3 Therapeutic Method
Patient takes the embodiment of the present invention 5 tablet, every day 2 times, each 2, is the l course for the treatment of with 1 month, continues 4 courses for the treatment of.
4 therapeutic evaluatioies
Be divided into invalid, effective, remarkable, recovery from illness.Effective percentage+significantly rate+add cure rate=total effective rate.1. invalid: before and after treatment, sings and symptoms is not any change, or aggravation.2. effective: the improvement of condition of illness and sign limited extent, the recovery of function limited extent.3. remarkable: condition of illness and sign disappear substantially, functional rehabilitation is normal, but still there will be sense of discomfort because of Changes in weather or tired etc.4. fully recover: condition of illness and sign disappear completely, and function recovers normal completely.
5 results
Through the treatment of 4 courses for the treatment of, 33 examples of fully recovering in 90 routine patients, remarkable 32 examples, effective l7 example, invalid 8 examples, total effective rate reaches 91.1%, and concrete statistical result is in table 1.
Table 1 the present invention treats hyperosteogeny curative effect statistics
Diseased region Case load Recovery from illness Significantly Effectively Invalid Total effective rate (%)
Knee joint 15 6 3 5 1 93.3
Lumbar vertebra 28 11 10 4 3 89.3
Cervical vertebra 47 16 19 8 4 91.5
Add up to 90 33 32 17 8 91.1
As shown in Table 1, after the treatment of 4 courses for the treatment of, the effective percentage of the embodiment of the present invention 5 pairs of knee joint hyperosteogenys is 93.3%, is 89.3% to the effective percentage of lumbar vertebra hyperosteogeny, being 91.5% to the effective percentage of hyperosteogeny of cervical vertebra, is 91.1% to the total effective rate of hyperosteogeny.Result shows: Chinese medicine composition of the present invention has good therapeutical effect to hyperosteogeny.
model case
Song XX, female, 56 years old, main suit is neck pain before 20 days, numbness of the fingers, heavy time light time dizzy, and light Shi Ruyi ordinary person is very dizzy time heavy.Be diagnosed as hyperosteogeny of cervical vertebra.Take the embodiment of the present invention 6 granule, when the 2nd week, symptom is clearly better, and numb disappearance after 1 month, after 1 first quarter moon, symptom disappears completely, is judged to recovery from illness.
Open XX, female, 58 years old.Main suit's double knee joint pain 4 years, limitation of activity, can not squat down, go to toilet, go up difficulty downstairs.Through multi-treatment, DeGrain, looks into: bilateral knee joint portion mild swelling, and local tenderness (+), X-ray film shows: double knee joint gap turn narrow, joint margins hyperosteogeny, and tibia spinous process of tibia comes to a point.Be diagnosed as bilateral knee hyperosteogeny.Take the embodiment of the present invention 4 capsule and namely feel pain relief in 5 days, take continuously after 2 months and fully recover, Effect of follow-up visit by telephone does not recur for 4 years.
Although above with general explanation, detailed description of the invention and test, the present invention is described in detail, and on basis of the present invention, can make some modifications or improvements it, this will be apparent to those skilled in the art.Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention, all belong to the scope of protection of present invention.

Claims (8)

1. treat a Chinese medicine composition for hyperosteogeny, it is characterized in that it is made up of the raw material comprising following weight portion:
Caulis Trachelospermi 6-20 part, Radix Dendropanacis 25-50 part, Caulis Piperis Kadsurae 6-20 part, Caulis Seu Folium Euonymi Fortunei 6-20 part, Rhizoma Ardisiae Gigantifoliae 15-40 part, yellow fluid Thalictrum omeiense W. T. Wang et S. H. Wang 20-40 part, Folium Perillae 5-20 part.
2. the Chinese medicine composition for the treatment of hyperosteogeny as claimed in claim 1, is characterized in that it is made up of the raw material comprising following weight portion:
Caulis Trachelospermi 10-15 part, Radix Dendropanacis 30-40 part, Caulis Piperis Kadsurae 10-15 part, Caulis Seu Folium Euonymi Fortunei 10-15 part, Rhizoma Ardisiae Gigantifoliae 20-30 part, yellow fluid Thalictrum omeiense W. T. Wang et S. H. Wang 25-35 part, Folium Perillae 10-15 part.
3. the Chinese medicine composition for the treatment of hyperosteogeny as claimed in claim 1, is characterized in that it is made up of the raw material comprising following weight portion:
Caulis Trachelospermi 12 parts, Radix Dendropanacis 35 parts, Caulis Piperis Kadsurae 12 parts, Caulis Seu Folium Euonymi Fortunei 12 parts, Rhizoma Ardisiae Gigantifoliae 25 parts, yellow fluid Thalictrum omeiense W. T. Wang et S. H. Wang 30 parts, Folium Perillae 12 parts.
4. the Chinese medicine composition of the treatment hyperosteogeny as described in any one of claim 1-3, is characterized in that its active component adopts the ethanol extraction of water extraction or 40-80% concentration expressed in percentage by volume to be prepared from.
5. the Chinese medicine composition for the treatment of hyperosteogeny as claimed in claim 4, it is characterized in that its active component is prepared from by the following method: get whole 7 taste medical materials, extracting in water 2-3 time after mixing, each amount of water is equivalent to the 6-12 of medical material gross weight doubly, each extraction time is 1-3 hour, merge extractive liquid, filters, when filtrate is concentrated into 70-80 DEG C, relative density is the clear paste of 1.15-1.20, obtains active component.
6. the Chinese medicine composition for the treatment of hyperosteogeny as claimed in claim 4, it is characterized in that its active component is prepared from by the following method: get whole 7 taste medical materials, 40-80% alcohol reflux 2-3 time is used after mixing, each ethanol consumption is 4-10 times of medical material total amount, extraction time is 1-4 hour, merge extractive liquid, filters, when filtrate is concentrated into 70-80 DEG C, relative density is the clear paste of 1.15-1.20, obtains active component.
7. the Chinese medicine composition for the treatment of hyperosteogeny as claimed in claim 4, it is characterized in that its active component is prepared from by the following method: get whole 7 taste medical materials, extracting in water 2-3 time after mixing, each amount of water is equivalent to the 6-12 of medical material gross weight doubly, each extraction time is 1-3 hour, merge extractive liquid, filter, when filtrate is concentrated into 70-80 DEG C, relative density is the clear paste of 1.15-1.20, add ethanol, alcohol content is made to be 40-70%, leave standstill 12-24 hour, filter, when filtrate is concentrated into 70-80 DEG C, relative density is the extractum of 1.10-1.25, obtain active component.
8. treat a pharmaceutical composition for hyperosteogeny, Chinese medicine composition and the pharmaceutically acceptable carrier combination of the treatment hyperosteogeny according to any one of claim 1-3 are prepared from.
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Publication number Priority date Publication date Assignee Title
CN105362491A (en) * 2015-11-25 2016-03-02 张立 External-use medicine for treating cervical vertebra hyperosteogeny
CN105362439A (en) * 2015-11-25 2016-03-02 张立 External medicine for treating lumbar vertebrae hyperosteogeny
CN105412395A (en) * 2015-11-27 2016-03-23 梁小琼 Traditional Chinese medicine composition for treating hyperostosis and preparation method thereof
CN106177662A (en) * 2016-08-16 2016-12-07 余昌仕 A kind of treat prominent Chinese medicine composition of hyperosteogeny, intercalated disc and preparation method thereof

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中国人民解放军解放军卅一野战医院,丰顺县革命委员会卫生服务站: "《常见病多发病中草药处方选》", 31 December 1969, article "8.处方", pages: 38-39 *
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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105362491A (en) * 2015-11-25 2016-03-02 张立 External-use medicine for treating cervical vertebra hyperosteogeny
CN105362439A (en) * 2015-11-25 2016-03-02 张立 External medicine for treating lumbar vertebrae hyperosteogeny
CN105412395A (en) * 2015-11-27 2016-03-23 梁小琼 Traditional Chinese medicine composition for treating hyperostosis and preparation method thereof
CN106177662A (en) * 2016-08-16 2016-12-07 余昌仕 A kind of treat prominent Chinese medicine composition of hyperosteogeny, intercalated disc and preparation method thereof

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