CN100352489C - Dog bone contained composition for treating rheumatoid arthritis - Google Patents

Abstract

The present invention relates to a dog bone contained composition for treating rheumatoid arthritis, which provides an oral pure Chinese herb composition for patients with rheumatoid arthritis. The dog bone contained composition is prepared from 17 kinds of Chinese herbs including dog bone, notopterygium root, pubescent angelica root, etc. The present invention has the advantages of simple preparation process and no toxic or side effect and is convenient to take. The present invention has the functions of relieving inflammation, eliminating swelling and quickly alleviating pain. Arthrodial cartilage and sclerotin symptoms can be recovered quickly, and the treatment cycle is short. The present invention has the therapeutic effect on various kinds of rheumatic arthritis.

Description

Treatment rheumatoid arthritis Os Canitis combination drug

Affiliated technical field

The present invention treats rheumatoid arthritis Os Canitis combination drug and belongs to treatment pure compound Chinese medicinal preparation of connective tissue disease and compound method thereof, relates in particular to a kind of pure Chinese medicine compound medicament and preparation technology thereof who contains Os Canitis treatment rheumatoid arthritis.

Background technology

Rheumatoid arthritis be a kind of be the disease of performance with the multiple joint of symmetry chronic inflammation disease, can be with abarticular systemic disease, its basic pathology form is a synovial membrane inflammation, outbreak can relate to articular cartilage and sclerotin repeatedly, and the skeleton joint part is suffered damage, and causes joint deformity, dysfunction, early stage, the patient was very painful, walking disorder, and patients with terminal can be lost viability.Cold, moist, malnutrition, undesirable elements such as direct stimulation are the main causes of bringing out rheumatoid arthritis, and patient age is 20-60 year, and the most common with the one's mid-40s middle age, female patient mostly is the rheumatoid arthritis in puerperal more than male person.

Treatment rheumatoid arthritis medicine is many based on Western medicine at present, medicine commonly used is non-steroidal antibiotics and adrenocortical hormone medicine, because said medicine often produces gastrointestinal upset and side effect such as hepatorenal damage, bone marrow depression and erythra, disease controlling at all again, drug withdrawal is easily recurred, Chinese medicine preparation is many with the external application plaster, inner disease outer treat, treatment cycle is long, and curative effect is not outstanding, the long-term pain of patient, quality of life extreme difference.

Summary of the invention

The objective of the invention is: provide a kind of pure compound Chinese medicinal preparation that includes Os Canitis, Formica fusca nutritional substance to rheumatoid arthritis patients, have no side effect, antiinflammatory, pain relieving, detumescence are rapid, it is fast that articular cartilage and sclerotin condition of illness recover, treatment cycle is short, and various types of rheumatic arthritis is all had outstanding curative effect.

To achieve these goals, the technical scheme that the present invention takes is: treatment rheumatoid arthritis Os Canitis medicament according to the rheumatoid arthritis main diseases because of, to improve articular cartilage functional rehabilitation sclerotin and to eliminate joint function disturbance is target, with the exterior cold of loosing, wind-damp dispelling, activating collaterals and eliminating stagnation, alleviating pain and detumescence is therapeutic purposes, select Os Canitis for use, black-snake, Formica fusca, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, Radix Saposhnikoviae, Herba Asari, Radix Angelicae Sinensis, Herba Lycopodii, Herba Erodii Herba Siegesbeckiae, the Radix Astragali, Fructus Hordei Germinatus, Radix Cynanchi Paniculati, Herba Aristolochiae Mollissimae, Pericarpium Zanthoxyli, Fructus Mori is the totally ten seven flavor Chinese herbal medicine side of closing compatibilities, it is granular at first to select for use the dog bones of limbs to be ground among the preparation technology, it is standby to take by weighing each tcm and herbal slice respectively by formula ratio again, with standby Rhizoma Et Radix Notopterygii, Herba Asari and Herba Aristolochiae Mollissimae extract oil preparation with percolation, adopt the decocting in water alcohol deposition method to extract with all the other tcm and herbal slices medicinal residues again and fry in shallow oil juice, oil preparation added fry in shallow oil in the juice mixing and make herb mixture, oral for the patient.Device simple, preparation technology is easy.The traditional Chinese medical science thinks that rheumatoid arthritis patients immerses human body mainly due to wind and cold, causes meridians painful abdominal mass plug, and QI-mass retardance is given birth in the phlegm-turbidity and blood stasis blood, causes arthralgia, morning deadlock and amyotrophy and joint deformity.According to Traditional Chinese medical theory, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, Radix Saposhnikoviae, Herba Asari, Herba Erodii five tastes Chinese herbal medicine have diffusing exterior cold, wind-damp dispelling, sharp joint respectively in treatment rheumatoid arthritis Os Canitis combination drug prescription, remove the arthralgia chiefly caused by damp pathogen effect; Radix Angelicae Sinensis, Herba Lycopodii, Herba Siegesbeckiae, Radix Cynanchi Paniculati, Herba Aristolochiae Mollissimae, black-snake, Os Canitis seven flavor Chinese crude drugs have relaxing muscles and tendons and activating QI and blood in the collateral, blood activating and promoting tissue regeneration, removing toxic substances and promoting subsidence of swelling, analgesia itching-relieving action respectively; Pericarpium Zanthoxyli, Fructus Mori, Fructus Hordei Germinatus, Formica fusca have warming spleen and stomach for dispelling cold, kidney and spleen invigorating, YIN nourishing and YANG strengthening, nourishing blood to promote the production of body fluid and blood circulation promoting and dispersing pathogen accumulation effect respectively; All medicines side of closing is tool treatment rheumatism persistent ailment, arthralgia, numb limbs and tense tendons, stiffness of the muscle and joint, deficiency of the liver and kindey, blood network stasis of blood curative effect such as stagnate altogether, treats rheumatoid arthritis effectively.Modern Chinese medicine pathology confirms, rheumatoid arthritis and environment, antibacterial or viral infection and gonadal hormone are relevant, with mycoplasma, mycobacterium, intestinal bacteria, the infection of some virus (as Epstein-Barr virus) is also relevant, it is synovitis that the basic pathology of primary disease changes, acute stage, show exudative process and cellular infiltration, the little vasodilation of synovial membrane lower floor, interstitial edema, chronic phase performance synovial membrane thickening, form many fine hair sample projections, prominent in articular cavity, and immerse articular cartilage and subchondral sclerotin, pathological changes beyond the joint also has rheumatoid subcutaneous nodule and rheumatoid vasculitis etc., and synovitis and vasculitis cause the long-term pain in joint unbearably.The modern Chinese medicine pharmacology confirms, the water decoction of volatile oil in the treatment rheumatoid arthritis Os Canitis combination drug in Rhizoma Et Radix Notopterygii, Herba Asari, the Herba Aristolochiae Mollissimae and Radix Angelicae Pubescentis, Radix Angelicae Sinensis, Herba Erodii, Herba Siegesbeckiae, Pericarpium Zanthoxyli, black-snake all has very strong antiinflammation, bacteriostasis and analgesic activity, can effectively treat synovitis and vasculitis; Rhizoma Et Radix Notopterygii also has the high blood coagulation tendency of improvement, and can suppress thrombosis, and Radix Saposhnikoviae has obvious booster action to the reticuloendothelial system activity; Contained xanthotoxin of Radix Angelicae Pubescentis and bergmot lactone have the painful effect of trivial solution; Radix Cynanchi Paniculati, Os Canitis, Radix Angelicae Sinensis and Herba Asari can QI invigorating be enriched blood, removing the necrotic tissue and promoting granulation, promoting blood circulation to remove blood stasis, improve the little vascular permeability of patient's synovial membrane lower floor jointly, eliminate interstitial edema, alleviate the synovial membrane exudative process, avoid cellular infiltration; The effect of tool nourishing YIN and benefiting blood, nourishing the liver and kidney, spleen invigorating tonifying YANG altogether of Herba Siegesbeckiae, Fructus Mori, Fructus Hordei Germinatus, Pericarpium Zanthoxyli, Main Ingredients and Appearance dog bone glue in the Os Canitis, warm in nature, acrid in the mouth is salty, belong to gentle tonic, have that spleen invigorating is active, the effect of blood activating and promoting tissue regeneration, Formica fusca is selected Formica fusca for use, has another name called black thorn ant, and body contains a large amount of protein, 8 kinds of essential amino acids, multiple needed by human body zinc, calcium, ferrum, manganese, magnesium, vitamin E, B ₁, B ₂, material such as adenosine diphosphate (ADP), also belong to gentle tonic, have strengthening the body resistance, kidney and spleen invigorating and YIN nourishing and YANG strengthening effect Herba Siegesbeckiae, Fructus Mori, Fructus Hordei Germinatus, Pericarpium Zanthoxyli, Os Canitis, patient body immunity can be improved and regulate to Formica fusca jointly, impel articular cartilage and synovial membrane and sclerotin morbid state to restore to the original state, the active ingredient performance property of medicine of lumping together can be treated rheumatoid arthritis effectively in the prescription.

The invention has the beneficial effects as follows: prescription thinking novelty, compatibility of drugs is proper, preparation technology is easy, various medicines are diffusing exterior cold in the prescription, wind-damp dispelling is used medicine always, have no side effect, use Os Canitis, the black thorn ant side of going into forms trophism treatment rheumatoid arthritis medicine, not only antiinflammatory, detumescence, pain relieving is rapid, and can accelerate articular cartilage and bone lesion and recover, all effective to all kinds of rheumatoid arthritis, utilize this prescription prescription drugs treat chronic rheumatoid arthritis and puerperal rheumatoid arthritis 300 examples, observe after three months, effective 279 examples are wherein cured 181 examples, produce effects 98 examples, invalid 21 examples, total effective rate are 93%.

Specific embodiments

1, treatment rheumatoid arthritis Os Canitis combination drug prescription is formed each Chinese crude drug optimum formula amount and degree such as following table in the prescription by 17 flavor Chinese crude drugs such as Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, Os Canitis:

The Chinese crude drug title	Os Canitis	Rhizoma Et Radix Notopterygii	Radix Saposhnikoviae	Herba Asari	Radix Angelicae Sinensis	Zaocys	Herba Lycopodii	Herba Erodii	Pig Xian	The Radix Astragali	Fructus Hordei Germinatus	Formica fusca	Radix Cynanchi Paniculati	Herba Aristolochiae Mollissimae	Pericarpium Zanthoxyli	Fructus Mori	Radix Angelicae Pubescentis	Add up to
																			Weight in the prescription (gram)	230	45	30	30	45	60	60	40	45	100	50	30	45	50	45	60	35	1000
Prescription degree (%)	23.0	4.5	3.0	3.0	4.5	6.0	6.0	4.0	4.5	10.0	5.0	3.0	4.5	5.0	4.5	6.0	3.5	100

2, treatment rheumatoid arthritis Os Canitis combination drug preparation technology: choose the dog bones of limbs before the preparation earlier and be ground into granularly, take by weighing standbyly by formula ratio, it is standby again all the other Chinese crude drugs to be taken by weighing decoction pieces respectively by formula ratio; Preparation technology adopts percolation and decocting in water alcohol deposition method, earlier with Rhizoma Et Radix Notopterygii, Herba Asari and Herba Aristolochiae Mollissimae are ground into powder No. 3, add 3 times of 75% ethanol, airtight immersion 3 hours, press per minute with percolator and flow out the leaching of 1-3ml amount, collect the immersion filtering and concentrating and become the oil preparation of former medicine weight standby, add 3 times of water gaging persons of frying in shallow oil three times after the more standby tcm and herbal slice of filtering residue and all the other being mixed at every turn, 3 hours for the first time, 2 hours for the second time, 1 hour for the third time, collecting decoction, filter, add again and former Chinese crude drug equivalent 75% ethanol mixing precipitation 24 hours, get supernatant and filter, heat and put to room temperature when being concentrated into former Chinese crude drug amount, add the oil preparation that percolation leaches, become herb mixture.

3, instructions of taking and points for attention: adult patient, every day is oral twice, and the time spent shakes up, each 20ml; Anemia of pregnant woman's forbidding.

Claims (2)

1, a kind of treatment rheumatoid arthritis Os Canitis combination drug is characterized in that: making active component raw material is Os Canitis 23.0%, Rhizoma Et Radix Notopterygii 4.5%, Radix Angelicae Pubescentis 3.5%, Radix Saposhnikoviae 3.0%, Herba Asari 3.0%, Radix Angelicae Sinensis 4.5%, black-snake 6.0%, Herba Lycopodii 6.0%, Herba Erodii 4.0%, Herba Siegesbeckiae 4.5%, the Radix Astragali 10.0%, Fructus Hordei Germinatus 5.0%, Formica fusca 3.0%, Radix Cynanchi Paniculati 4.5%, Herba Aristolochiae Mollissimae 5.0%, Pericarpium Zanthoxyli 4.5%, Fructus Mori 6.0%.

2, preparation technology according to the described treatment rheumatoid arthritis of claim 1 Os Canitis combination drug, it is characterized in that: it is granular at first to select for use the dog bones of limbs to be ground into, with Rhizoma Et Radix Notopterygii, Herba Asari and Herba Aristolochiae Mollissimae are ground into powder No. 3, add 3 times of 75% ethanol, airtight immersion 3 hours, press per minute with the seepage tube and flow out the leaching of 1-3ml amount, collecting the immersion filtering and concentrating becomes the oil preparation of former medicine weight standby, again filtering residue is mixed with all the other tcm and herbal slices and add 3 times of water gagings decoctions three times at every turn, 3 hours for the first time, 2 hours for the second time, 1 hour for the third time, collecting decoction, filter, added former Chinese crude drug equivalent 75% ethanol mixing precipitation again 24 hours, get supernatant and filter, heat and put to room temperature when being concentrated into former Chinese crude drug amount, add the oil preparation that seepage leaches and to treat rheumatoid arthritis Os Canitis combination drug.