CN106728807A

CN106728807A - It is a kind of to treat medicine of rheumatic heart disease and preparation method thereof

Info

Publication number: CN106728807A
Application number: CN201710130474.1A
Authority: CN
Inventors: 李子义
Original assignee: Individual
Current assignee: Individual
Priority date: 2017-03-07
Filing date: 2017-03-07
Publication date: 2017-05-31

Abstract

Medicine of rheumatic heart disease and preparation method thereof is treated the invention discloses a kind of, it is mainly and is prepared from according to a certain weight ratio by Radix Angelicae Sinensis, the Radix Astragali, cassia twig, the root bark of Chinese wolf-berry, Poria cocos, bark of ash, the capsule of weeping forsythia, the bark of official magnolia, radix pseudostellariae, the root of fangji, Radix Glycyrrhizae, lily, balloonflower root, radix cyathulae, dried orange peel, the dried immature fruit of citron orange, Asiatic plantain, reticulate millettia, Radix Codonopsis, fruit of Chinese magnoliavine etc., medicine of the present invention defends solid table with benefit, tonifying middle-Jiao and Qi, tonifying lung, kidney tonifying, beneficial spleen and stomach, the function of antitoxic heart-soothing and sedative, for treating rheumatic heart disease instant effect, good effect, do not recur.

Description

It is a kind of to treat medicine of rheumatic heart disease and preparation method thereof

Technical field

Medicine of rheumatic heart disease and preparation method thereof is treated the present invention relates to a kind of, belongs to the field of Chinese medicines.

Technical background

Rheumatic heart disease refers to due to rheumatic fever activity, the valve disorder for involving cardiac valves and causing.The traditional Chinese medical science Then think rheumatic heart disease and the stagnation of the heart blood, qi-blood deficiency, the heart insufficiency of both the spleen and the kindey is relevant.Because western medicine side effect is big, because There is great demand to the Chinese medicine of effectively treatment rheumatic heart disease in this people, up to now, it has not been found that on Relevant report of the invention.

The content of the invention

The present inventor have found effectively treatment rheumatism finally according to the checking repeatedly of research and the clinical test of theory of traditional Chinese medical science The cardiopathic medicine of property, so as to complete the present invention.

It is an object of the invention to provide a kind of Chinese medicine composition of effective treatment rheumatic heart disease.

Another object of the present invention just there is provided the preparation method of the Chinese medicine composition.

Medicine of the present invention is the selection Radix Angelicae Sinensis, Radix Astragali, cassia twig, the root bark of Chinese wolf-berry, Poria cocos, bark of ash, the capsule of weeping forsythia, the bark of official magnolia, radix pseudostellariae, anti- Oneself, Radix Glycyrrhizae, lily, balloonflower root, radix cyathulae, dried orange peel, the dried immature fruit of citron orange, Asiatic plantain, reticulate millettia, Radix Codonopsis, the fruit of Chinese magnoliavine, barrenwort are combined system Standby, these drug regimens are caused that each efficacy of drugs produces synergy such that it is able to effectively treat rheumatic heart disease.Its Middle selection Radix Angelicae Sinensis has benefiting blood and regulating blood circulation, menstruction regulating and pain relieving, the work(of moisturize laxation because its nature and flavor sweet, acrid, warm, enters the heart, liver, the spleen channel Can, irregular menstruation is controlled, Amenorrhea stomachache , Disorder lumps in the abdomen knot gathers, and uterine bleeding, headache due to deficiency of blood, dizziness, Impotence numbness, intestinal dryness is difficult just, weight, carbuncle after dysentery characterized by blood in the stool Subcutaneous ulcer sore, metal-inflicted wound, injury from falling down.From the Radix Astragali because its nature and flavor is sweet, tepor enters lung, the spleen channel, raw to defend solid table, profit with beneficial Water is subsided a swelling, eliminating toxic, the function of myogenic, controls spontaneous perspiration, and night sweat, blood-arthralgia, edema, ulcer is not burst or burst and holds back long；Process to use and have bowl spares benefit Function, controls internal injury overstrain, and splenasthenic diarrhea, prolapse of the anus, deficiency of vital energy blood takes off, and collapses band and the disease of all laboured breathing deficiency of blood.From cassia twig because Its property acrid-sweet flavor, temperature, enters bladder, the heart, lung channel, there is sweating expelling pathogenic factors from muscles and skin, and the function of warming meridians and promoting circulation of qi controls exterior syndrome due to wind-cold, shoulder back of the body podomere acid Pain, obstruction of qi in the chest phlegm and retained fluid, Jing Bi Disorder lumps in the abdomen.From the root bark of Chinese wolf-berry because its nature and flavor is sweet, tremble with fear, enter lung, liver and kidney channel, there is heat-clearing, the work(of cool blood Can, consumptive disease hectic fever night sweat is controlled, lung heat cough and asthma is spitted blood, and bleeding from five sense organs or subcutaneous tissue, blood strangury is quenched one's thirst, hypertension, carbuncle swells, dislikes sore.From Poria cocos be because It is its property slightly sweet flavor, puts down, enter the heart, spleen, lung channel, there is eliminating dampness and diuresis, beneficial spleen and stomach, the function of antitoxic heart-soothing and sedative controls difficult urination, water Swelling is expired, and phlegm and retained fluid coughs inverse, the sound of vomiting of vomitting, and diarrhea, seminal emission, stranguria with turbid discharge, palpitation with fear is forgetful.From bark of ash because its nature and flavor toil, puts down, enter Liver, stomach, gallbladder channel, there is dispelling wind and eliminating dampness, and blood relaxing muscles and tendons, and the function of reducing fever and causing diuresis controls arthralgia pain due to rheumatism, and muscles and bones contraction, jaundice is had blood in stool, Osteopyrexia and fever, children's infantile malnutrition due to digestive disturbances or intestinalparasites heat, difficult urination.It is cool from the capsule of weeping forsythia because its is bitter in taste, enter the heart, liver, gallbladder channel, there is heat-clearing, solve Poison, dissipating bind, the function of detumescence controls warm, erysipelas, macula, large carbuncle pyogenic infections, scrofula, urine leaching closes.From the bark of official magnolia because its property Bitter is pungent, temperature, enters spleen, stomach, large intestine channel, there is a middle benefit gas, lower gas, eliminating dampness, the function of dissolving phlegm, controls chest and abdomen feeling of fullness distending pain, gastric disorder causing nausea, vomits Tell, place food does not disappear, phlegm and retained fluid is breathed with cough, cold-dampness rush down dysentery.From radix pseudostellariae because its nature and flavor sweetness and bitterness, tepor, enter the heart, spleen, the warp of lung three, There are tonifying lung, the function of invigorating the spleen, control cough due to deficiency of the lung, spleen eating less, palpitaition mesh sweat, metal fatigue.From the root of fangji because its nature and flavor Hardship, trembles with fear, and enters wing thorax, spleen, kidney channel, there is water-filling, rushes down the function of damp-heat in lower-JIAO, controls oedema tympanites, hygropyretic beriberi, brothers' contraction bitterly, tinea Scabies swells.From Radix Glycyrrhizae because its property sweet taste, enters spleen, stomach, lung channel, have and detoxify with middle emergency, moistening lung, coordinating the drug actions of a prescription Function, processs, deficiency of food weakness of the spleen and the stomach with controlling, loose stool of suffering from abdominal pain, overstrain heating, consumptive lung disease cough, palpitaition, shies carbuncle, raw with controlling abscess of throat, Peptic ulcer, ulcer sores, antidote poison and food poisoning.From lily because its property sweet and slightly bitter taste, puts down, enter the heart, lung channel, Moisten the lung and relieve the cough, the function of clearing away the heart fire and tranquillizing is controlled tuberculosis and coughed long, cough saliva phlegm blood, waste heat is not clear after pyreticosis, dysphoria palpitates with fear, and mind is all of a sudden Hu, beriberi edema.From balloonflower root because its nature and flavor toil, put down, enter lung, stomach, there is out facilitaing lung gas, the function of eliminating the phlegm apocenosis, Control exogenous cough, abscess of throat, lung carbuncle pyemesis, fullness in the chest and hypochondriac pain, dysentery stomachache.From radix cyathulae because its nature and flavor is flat, bitter Slight bitter, nontoxic, enter liver, kidney two warp have wind-dispelling, and dampness removing stimulates the menstrual flow, the function of promoting blood circulation, control rheumatism lumbocrural pain, pin impotence muscle contraction, blood Drench, hematuria, women's Amenorrhea , Disorder lumps in the abdomen.From dried orange peel because its is bitter in taste, pungent, temperature, return lung, the spleen channel have regulating qi-flowing for strengthening spleen, eliminating dampness The function of resolving sputum, controls chest gastral cavity turgor, and deficiency of food is vomited and diarrhoea, coughing with a lot of sputum.From the dried immature fruit of citron orange because its is bitter in taste, tremble with fear, enter spleen, stomach, Have relieving stagnant Qi, dissipate ruffian, rush down phlegm, the function of disperse accumulations controls chest and abdomen swelling and pain, the obstruction of qi in the chest, ruffian bitterly, phlegm addiction, oedema, dyspepsia, constipation, gastroptosis, Metroptosis, prolapse of the anus.From Asiatic plantain because its nature and flavor is sweet, tremble with fear, enter liver, spleen two are passed through, favourable water, heat-clearing, improving eyesight, eliminating the phlegm Function, controls urinary obstruction, and stranguria with turbid discharge, under band, hematuria, jaundice, oedema, hot dysentery, diarrhea, nosebleed epistaxis, red eye, swell pain, larynx numbness acute tonsillitis coughs Cough, skin ulcer.From reticulate millettia because its nature and flavor bitter sweet, temperature, enter the heart, the warp of spleen two, there is the function of promoting blood circulation, relaxing muscles and tendons, control waist Knee joint soreness, paralysis and numbness, irregular menstruation.From Radix Codonopsis because its nature and flavor is sweet, put down, start with, meridian of Foot-TAI YIN qi leel, there is bowl spares benefit Gas, the function of promoting the production of body fluid controls weakness of the spleen and the stomach, and qi-blood deficiency, body is tired powerless, and deficiency of food is thirsty, chronic diarrhea, prolapse of the anus.From the fruit of Chinese magnoliavine be because It is the acid of its nature and flavor, temperature enters lung, kidney channel, astringes the lung, and nourshing kidney is promoted the production of body fluid, receives sweat, the function of puckery essence is controlled the deficiency syndrome of the lung and breathed with cough, thirst, Spontaneous perspiration, night sweat, internal lesion caused by overexertion is thin thin, emission, protracted dysentery and diarrhea.From barrenwort because its property acrid-sweet flavor, temperature, enter liver and kidney channel, There is tonifying kidney and strengthening yang, the function of dispelling wind and eliminating dampness is controlled impotence and do not lifted, dribbling urination, muscles and bones contraction urgency, hemiplegia, waist-leg weakness, rheumatism Numbness pain, four pin are meciless.

Specific embodiment

The drug dose of instant component is also that inventor summarizes what is drawn by largely groping, and the consumption of each component is following heavy All there is preferable curative effect in the range of amount：

5-15 grams of Radix Angelicae Sinensis, 10-20 grams of the Radix Astragali, 5-10 grams of cassia twig, 10-20 grams of the root bark of Chinese wolf-berry, 10-20 grams of Poria cocos, 5-15 grams of bark of ash, even Stick up 15-25 grams, 10-15 grams of the bark of official magnolia, 15-25 grams of radix pseudostellariae, 15-25 grams of the root of fangji, 10-15 grams of Radix Glycyrrhizae, 10-20 grams of lily, balloonflower root 5-15 grams, 5-15 grams of radix cyathulae, 5-15 grams of dried orange peel, 10-15 grams of the dried immature fruit of citron orange, 15-20 grams of Asiatic plantain, 10-20 grams of reticulate millettia, Radix Codonopsis 10-20 grams, 5-15 grams of the fruit of Chinese magnoliavine, 5-15 grams of barrenwort.

Preferably：

10 grams of Radix Angelicae Sinensis, 15 grams of the Radix Astragali, 8 grams of cassia twig, 15 grams of the root bark of Chinese wolf-berry, 15 grams of Poria cocos, 10 grams of bark of ash, 20 grams of the capsule of weeping forsythia, 12 grams of the bark of official magnolia, 20 grams of radix pseudostellariae, 20 grams of the root of fangji, 12 grams of Radix Glycyrrhizae, 15 grams of lily, 10 grams of balloonflower root, 10 grams of radix cyathulae, 10 grams of dried orange peel, 12 grams of the dried immature fruit of citron orange, 18 grams of Asiatic plantain, 15 grams of reticulate millettia, 15 grams of Radix Codonopsis, 10 grams of the fruit of Chinese magnoliavine, 10 grams of barrenwort.

The preparation method of medicine of the present invention is as follows

First, get the raw materials ready

1st, Radix Angelicae Sinensis：Impurity is picked, is cleaned, vexed profit is slightly dried in the air, and section is dried；

2nd, the Radix Astragali：Net impurity is picked, the root head and hollow the greater of residual is removed, is soaked in water, pulled out, section in time after running through, Dry；

3rd, cassia twig：Slightly soaked with water, pulled out, vexed profit is dried to saturating, section, weeds out bits；

4th, the root bark of Chinese wolf-berry：Impurity and core are picked, is slightly washed, segment is dried；

5th, Poria cocos：Be soaked in water, clean, pull out, it is vexed after, cut into slices, dry；

6th, bark of ash：Impurity is picked, except removing LU, is slightly soaked, run through section, dried；

7th, the capsule of weeping forsythia：Net impurity is picked, stranding is opened, except discarding stalk；

8th, the bark of official magnolia：It is soaked in water and pulls out, tertia is scraped off after running through, clean, chopping is dried；

9th, radix pseudostellariae：Fibrous root is extractd, is dried；

10th, the root of fangji：Active compound is washed, and is pulled out and is run through, section, is dried；

11st, Radix Glycyrrhizae：Extracting liquorice piece adds cooked honey and boiling water a little, mixes thoroughly, slightly vexed, puts the interior slow fire of pot and fries to being changed into deep yellow Color, it is tack-free untill, taking-up is cooled, per 100 jin of Radix Glycyrrhizae, with refined honey 25-30 jins；

12nd, lily：Pick impurity, black valve, ash disposal of winnowing with a dustpan bits；

13rd, balloonflower root：Net impurity is picked, except removing LU, is cleaned and is pulled out, cut into slices after running through, dried；

14th, radix cyathulae：Impurity is picked, is dried；

15th, dried orange peel：Crude drug is taken, the pericarp of impurity and blackening is removed, wash quickly is net, softens, chopping, dries or low temperature drying, Weed out grey bits；

16th, the dried immature fruit of citron orange：Net impurity is picked, is soaked in water to eighty per cant thoroughly, pulled out, profit to interior without hard-core, dry by section；

17th, Asiatic plantain：Most soil is removed, is dried；

18th, reticulate millettia：Run through with water, cut into slices, or steam it is soft after multiply fervent piece, dry；

19th, Radix Codonopsis：Reed, section or segment are run through after cleaning silt, is dried；

20th, the fruit of Chinese magnoliavine：Grey bits are weeded out, impurity is removed, is put and steamed in food steamer saturating, taking-up is dried；

21st, barrenwort：Net impurity is picked, stalk is removed, chopping weeds out chip.

2nd, prepare

1st, by the Radix Angelicae Sinensis of the weight, the Radix Astragali, cassia twig, the root bark of Chinese wolf-berry, Poria cocos, bark of ash, the capsule of weeping forsythia, the bark of official magnolia, radix pseudostellariae, the root of fangji, Radix Glycyrrhizae, Lily, balloonflower root, radix cyathulae, dried orange peel, the dried immature fruit of citron orange, Asiatic plantain, reticulate millettia, Radix Codonopsis, the fruit of Chinese magnoliavine, barrenwort are put into decocting container, the Once add water 6 times and measure, after soaking 100 minutes, fry by intense fire to boil and rise, then with being cooked by slow fire 20 minutes, filter to obtain decoction for the first time Liquid, first time decoction liquor is poured into container；

2nd, the dregs of a decoction of filtering are added water 4 times and is measured, boiled by intense fire, then with being cooked by slow fire 20 minutes, filter to obtain second decoction liquor；

3rd, will decoction liquor mixing and stirring twice, be divided into 2 doses and take.

The Radix Astragali is beneficial in prescription defends solid table, inducing diuresis for removing edema, eliminating toxic, and the function of myogenic is monarch drug in a prescription；Radix pseudostellariae tonifying lung, invigorating the spleen； Radix Codonopsis tonifying middle-Jiao and Qi, promotes the production of body fluid, and the two is ministerial drug, and three taste medicines play benefit and defend solid table jointly, and inducing diuresis for removing edema, tonifying middle-Jiao and Qi, tonifying lung is good for The effect of spleen, treatment rheumatic heart disease effect comprehensively, and defends solid table with benefit, tonifying middle-Jiao and Qi, tonifying lung, can be effected a permanent cure based on invigorating the spleen, Poria cocos has an eliminating dampness and diuresis, beneficial spleen and stomach, and the function of antitoxic heart-soothing and sedative is adjutant, and barrenwort has tonifying kidney and strengthening yang, the function of dispelling wind and eliminating dampness To make medicine, all medicines are to take stopgap measures with being left.

Medicine of the present invention defends solid table with benefit, and tonifying middle-Jiao and Qi, tonifying lung, kidney tonifying, beneficial spleen and stomach, the function of antitoxic heart-soothing and sedative is used In treatment rheumatic heart disease, short treating period, instant effect, non-relapse after healing.

The beneficial effect of medicine of the present invention is expanded on further below by way of test example, these test examples include this hair The animal toxicity test report of bright medicine and clinical observation on the therapeutic effect data.

The animal toxicity test report of [test example 1] medicine of the present invention：

Rabbit 30 is taken, male and female dual-purpose, 2.0-2.5kg of body weight is divided to two groups, and every group 15, one of which is tested for overdose Group, another group is normal amount test group.Super quantity group is 20ml/kg, and normal amount is 10ml/kg, and administering mode is given for administration by gavage Medicine, twice daily, takes medicine continuously 7 days, the reaction of observation administration daily, as a result shows that two groups of rabbit activities, diet are normal, and medicine is without bad Toxic and side effect.

The clinical observation on the therapeutic effect of [test example 2] medicine of the present invention

1st, physical data

Accept rheumatic heart disease out-patient totally 22 for medical treatment.

2nd, diagnostic criteria

Classical symptom is angina pectoris, dizziness, expiratory dyspnea, hidrosis and palpitaition, severe patient it is possible that sudden death etc..

3rd, treatment method

From above-mentioned medicament, taken to patient, each take 1 dose, early daily, evening respectively takes 1 time, be within 10 days a course for the treatment of, continuously Take 3 courses for the treatment of.

4th, efficacy assessment standard

It is effective：Rheumatic heart disease symptoms disappear, and constitution recovers normal, recovery from illness；

Take a turn for the better：The symptom of angina pectoris, dizziness, expiratory dyspnea, hidrosis and palpitaition is clearly better, and constitution is progressively recovered；

It is invalid：Improvement standard person is not reached.

5th, treatment results（See the table below）

In above-mentioned treatment, with drug therapy Patients With Rheumatic Valvular Disease of the present invention 22, as a result effective 15, obvious effective rate is 68.19%, take a turn for the better 5, improvement rate is 22.72%, and invalid 1, total effective rate is 90.91%.

Claims

1. a kind of medicine for treating rheumatic heart disease, it is characterised in that：It is made up of the bulk drug in following weight range：

2. medicine according to claim 1, wherein the consumption of each bulk drug is：

3. the preparation method of medicine according to claim 1 or claim 2, it comprises the following steps：

（One）Get the raw materials ready

（1）Radix Angelicae Sinensis：Impurity is picked, is cleaned, vexed profit is slightly dried in the air, and section is dried；

（2）The Radix Astragali：Net impurity is picked, the root head and hollow the greater of residual is removed, is soaked in water, pulled out, section in time after running through, Dry；

（3）Cassia twig：Slightly soaked with water, pulled out, vexed profit is dried to saturating, section, weeds out bits；

（4）The root bark of Chinese wolf-berry：Impurity and core are picked, is slightly washed, segment is dried；

（5）Poria cocos：Be soaked in water, clean, pull out, it is vexed after, cut into slices, dry；

（6）Bark of ash：Impurity is picked, except removing LU, is slightly soaked, run through section, dried；

（7）The capsule of weeping forsythia：Net impurity is picked, stranding is opened, except discarding stalk；

（8）The bark of official magnolia：It is soaked in water and pulls out, tertia is scraped off after running through, clean, chopping is dried；

（9）Radix pseudostellariae：Fibrous root is extractd, is dried；

（10）The root of fangji：Active compound is washed, and is pulled out and is run through, section, is dried；

（11）Radix Glycyrrhizae：Extracting liquorice piece adds cooked honey and boiling water a little, mixes thoroughly, slightly vexed, puts the interior slow fire of pot and fries to being changed into deep yellow Color, it is tack-free untill, taking-up is cooled, per 100 jin of Radix Glycyrrhizae, with refined honey 25-30 jins；

（12）Lily：Pick impurity, black valve, ash disposal of winnowing with a dustpan bits；

（13）Balloonflower root：Net impurity is picked, except removing LU, is cleaned and is pulled out, cut into slices after running through, dried；

（14）Radix cyathulae：Impurity is picked, is dried；

（15）Dried orange peel：Crude drug is taken, the pericarp of impurity and blackening is removed, wash quickly is net, softens, chopping, dries or low temperature drying, Weed out grey bits；

（16）The dried immature fruit of citron orange：Net impurity is picked, is soaked in water to eighty per cant thoroughly, pulled out, profit to interior without hard-core, dry by section；

（17）Asiatic plantain：Most soil is removed, is dried；

（18）Reticulate millettia：Run through with water, cut into slices, or steam it is soft after multiply fervent piece, dry；

（19）Radix Codonopsis：Reed, section or segment are run through after cleaning silt, is dried；

（20）The fruit of Chinese magnoliavine：Grey bits are weeded out, impurity is removed, is put and steamed in food steamer saturating, taking-up is dried；

（21）Barrenwort：Net impurity is picked, stalk is removed, chopping weeds out chip；

（Two prepare）

（1）By the Radix Angelicae Sinensis of the weight, Radix Astragali, cassia twig, the root bark of Chinese wolf-berry, Poria cocos, bark of ash, the capsule of weeping forsythia, the bark of official magnolia, radix pseudostellariae, the root of fangji, sweet Grass, lily, balloonflower root, radix cyathulae, dried orange peel, the dried immature fruit of citron orange, Asiatic plantain, reticulate millettia, Radix Codonopsis, the fruit of Chinese magnoliavine, barrenwort are put into decocting container, Add water 6 times and measure, after soaking 100 minutes, fry by intense fire to boil and rise, then with being cooked by slow fire 20 minutes, filter to obtain first time decoction liquor, will First time decoction liquor is poured into container；

（2）The dregs of a decoction of filtering are added water 4 times and is measured, boiled by intense fire, then with being cooked by slow fire 20 minutes, filter to obtain second decoction liquor；

（3）Decoction liquor mixing and stirring twice is incited somebody to action, is divided into 2 doses and is taken.