CN104984186A - Traditional Chinese medicine tablet for treating diabetes and preparing method thereof - Google Patents

Abstract

The invention provides a traditional Chinese medicine tablet for treating diabetes and a preparing method thereof and relates to the technical field of treatment of diabetes. The traditional Chinese medicine tablet mainly aims to solve the problem that it is difficult to restrain subsequent complications while the diabetes is treated. The effective ingredients of raw material medicine for making the tablet comprises, by mass, 20-35 parts of gallnut, 9-21 parts of mulberries, 14-28 parts of bitter gourd, 10-25 parts of guava, 6-18 parts of rhizome of rehmannia, 17-29 parts of glossy privet fruits, 8-26 parts of radix polygonati officinalis, 10-21 parts of radix asparagi, 7-22 parts of plaster stone, 12-27 parts of poria cocos, 10-24 parts of cortex lycii radicis, 15-35 parts of honeysuckle, 5-25 parts of pipewort, 10-30 parts of Chinese yam, 5-25 parts of citron peel, 8-26 parts of mangnolia officinalis, 17-31 parts of roots of common peony, 7-22 parts of herba lycopi, 10-25 parts of winged euonymus twigs and 12-27 parts of rhizoma sparganii. By means of the traditional Chinese medicine tablet, treatment of the diabetes can be promoted, and the total treatment effective rate reaches over 98%.

Description

A kind of Chinese medicinal tablet for the treatment of diabetes and preparation method thereof

Technical field

The present invention relates to treatment diabetes technical field, specifically a kind of Chinese medicinal tablet for the treatment of diabetes and preparation method thereof.

Background technology

Diabetes are that the normal fasting blood sugar of present stage reference is 3.9 ~ 6.1mmol/L, if fasting glucose exceedes peak 6.1mmol/L, will be diagnosed as diabetes because our fasting glucose is too high.Diabetes are defined as lifelong disease always.The traditional Chinese medical science thinks the one-tenth Anttdisease Mechanism mainly ferritic deficiency of YIN of diabetes, and the five internal organs are weak, multiple because of eating and drinking without temperance, surfeit delicious food, disorder of emotion, and labor for excessively, and causes deficiency of kidney-YIN, lung dryness of the stomach heat; Pathogenesis emphasis is that the deficiency of YIN is scorching, and is this with the deficiency of YIN, and scorching is mark; With the passing of time disease prolongs, deficiency of YIN affecting YANG, deficiency in both YIN and YANG; The deficiency of YIN is scorching, and consumption Tianjin liquid that burns makes blood viscous, and blood is not smooth forms the stasis of blood; Deficiency of YIN affecting YANG, yang deficiency cold coagulation, also can cause sun in blood stasis.

At present, most of doctor can hold three major types medicine to diabetes patient: one, insulin, this is born with secernent thing in our sky, the morbidity root of diabetes is exactly hypoinsulinism, but because insulin is easily destroyed by digestive enzyme in gastrointestinal tract, so general not oral, but subcutaneous injection is main.Insulin human is made up of A and B two peptide chains, really want to treat diabetes, the secretion level of own insulin must be recovered, do not have diabetes when most diabetics youth, because pancreatic function is powerful when youth, the insulin of production can ensure human body needs, but with age, physical function declines, and secretory volume is not much of that, thus forms diabetes.Two, sulfonylurea, concrete medicine: glipizide, glibenclamide, gliclazide, glibornuride, gliquidone etc.This kind of medicine can stimulate your many excreting insulins, and so your pancreas can be more and more weaker, finally loses excreting insulin function, then have to enter the next medication stage, namely the 3rd class medicine.Three, biguanide drug represents medicine: phenformin, metformin.This kind of medicine still has the patient that islet function completely loses and falls hypoglycemic effect, but its pharmacological action promotes to organize ingestion of glucose, and that is original glucose in blood, under this drug effect, can enter tissue.After taking medicine, blood glucose has fallen, and the glucose in organ is many, can accelerate organ failure like this.Cannot see to last eyes, there is bad maggot in trick acra, exhaustion appears in internal organs, is exactly that metabolism does not catch up with, and this type of medicine is treating the disease of diabetes own of standard, but can not suppress the appearance of consecutive complications.

Summary of the invention

The object of the invention is to overcome the above problems, and provide while the treatment carried out diabetes, to a kind of Chinese medicinal tablet for the treatment of diabetes that consecutive complications also suppresses and preparation method thereof.

The technical solution used in the present invention is: a kind of Chinese medicinal tablet for the treatment of diabetes, the crude drug effective ingredient mass fraction making tablet comprises: Galla Chinensis 20 ~ 35 parts, Fructus Mori 9 ~ 21 parts, 14 ~ 28 parts, Fructus Momordicae charantiae, Fructus psidii guajavae immaturus 10 ~ 25 parts, 6 ~ 18 parts, the Radix Rehmanniae, Fructus Ligustri Lucidi 17 ~ 29 parts, Rhizoma Polygonati Odorati 8 ~ 26 parts, Radix Asparagi 10 ~ 21 parts, Gypsum Fibrosum 7 ~ 22 parts, 12 ~ 27 parts, Poria, Cortex Lycii 10 ~ 24 parts, Radix Ophiopogonis 15 ~ 35 parts, Flos Eriocauli 5 ~ 25 parts, Rhizoma Dioscoreae 10 ~ 30 parts, Pericarpium Citri 5 ~ 25 parts, Cortex Magnoliae Officinalis 8 ~ 26 parts, Radix Paeoniae Rubra 17 ~ 31 parts, Herba Lycopi 7 ~ 22 parts, Ramulus Euonymi 10 ~ 25 parts, Rhizoma Sparganii 12 ~ 27 parts.

Further, a kind of Chinese medicinal tablet for the treatment of diabetes, the crude drug effective ingredient mass fraction making tablet comprises: Galla Chinensis 25 ~ 30 parts, Fructus Mori 14 ~ 17 parts, 19 ~ 23 parts, Fructus Momordicae charantiae, Fructus psidii guajavae immaturus 15 ~ 20 parts, 11 ~ 13 parts, the Radix Rehmanniae, Fructus Ligustri Lucidi 21 ~ 24 parts, Rhizoma Polygonati Odorati 13 ~ 21 parts, Radix Asparagi 15 ~ 18 parts, Gypsum Fibrosum 15 ~ 18 parts, 17 ~ 22 parts, Poria, Cortex Lycii 15 ~ 19 parts, Radix Ophiopogonis 20 ~ 30 parts, Flos Eriocauli 10 ~ 20 parts, Rhizoma Dioscoreae 15 ~ 25 parts, Pericarpium Citri 10 ~ 20 parts, Cortex Magnoliae Officinalis 13 ~ 21 parts, Radix Paeoniae Rubra 22 ~ 27 parts, Herba Lycopi 12 ~ 17 parts, Ramulus Euonymi 15 ~ 20 parts, Rhizoma Sparganii 17 ~ 22 parts.

Further, treat a Chinese medicinal tablet for diabetes, the crude drug effective ingredient mass fraction making tablet comprises: Galla Chinensis 27 parts, Fructus Mori 16 parts, 21 parts, Fructus Momordicae charantiae, Fructus psidii guajavae immaturus 17 parts, 12 parts, the Radix Rehmanniae, Fructus Ligustri Lucidi 22 parts, Rhizoma Polygonati Odorati 17 parts, Radix Asparagi 17 parts, Gypsum Fibrosum 16 parts, 20 parts, Poria, Cortex Lycii 17 parts, Radix Ophiopogonis 25 parts, Flos Eriocauli 25 parts, Rhizoma Dioscoreae 20 parts, Pericarpium Citri 15 parts, Cortex Magnoliae Officinalis 17 parts, Radix Paeoniae Rubra 24 parts, Herba Lycopi 14 parts, Ramulus Euonymi 17 parts, Rhizoma Sparganii 20 parts.

Further, a kind of preparation method for the treatment of the Chinese medicinal tablet of diabetes, preparation method is as follows:

(1) soak: take each raw material by above-mentioned mass fraction, gross weight is designated as 1 part, adds 6 parts of purified water, 50 DEG C are soaked 1h, obtain soak;

(2) decoct: after the soak that step (1) obtains being heated to boiling, boil 2h, be separated and take out fried liquid, continue the purified water adding 4 parts in medical material, continue to boil 1.5h after being heated to boiling, merge twice fried liquid and be extracting solution;

(3) supercritical extraction: the extracting solution that step (2) obtains is positioned in the extraction kettle in supercritical extraction instrument, carbon dioxide is utilized to extract as medium, extraction kettle pressure is 40Mpa, extraction temperature is 45 DEG C, separator pressure 12Mpa, separator temperature is 70 DEG C, extracts 2 hours, is extracted liquid;

(4) concentrated: extract step (3) obtained concentrates at outer circulation concentrator, and concentrated condition is: pressure 0.03Mpa, temperature 70 C, is concentrated into the extractum that relative density is 1.13;

(5) by extractum obtained for step (4) and the starch or the Icing Sugar Homogeneous phase mixing that account for extractum gross mass 10%, cross 16 mesh sieves and make wet grain, grain will be wet in 50 DEG C of dryings, with 16 mesh sieve granulate, add the magnesium stearate accounting for medicine gross mass 1%, mixing, is pressed into tablet with tablet machine, every sheet 0.8 gram.

Instructions of taking: every day three times, an a slice 10 days is a course for the treatment of.

Medical material effect of the present invention is resolved as follows:

Galla Chinensis sour in the mouth, puckery, cold in nature, have pathogenic fire reducing of astringing the lung, relieving diarrhea with astringents, arresting sweating, hemostasis, effect of removing dampness sore, be mainly used in treating chronic cough of deficiency lung, lung-heat phlegmatic cough, chronic diarrhea chronic dysentery, spontaneous sweating, quenches one's thirst, hemorrhoidal bleeding of having blood in stool, traumatic hemorrhage, carbuncle sore tumefacting virus, Skin wet and rotten.The acid of Fructus Mori sweet in the mouth, cold nature, there is the liver and the kidney tonifying, intestine moistening of promoting the production of body fluid, the effect such as black hair improving eyesight, cure mainly deficiency of YIN-blood and cause have a dizzy spell, tinnitus cardiopalmus, irritated insomnia, soreness of the waist and knees, early whitening of beard and hair, the disease such as xerostomia, constipation with dry stool of quenching one's thirst.Fructus Momordicae charantiae abnormal smells from the patient is bitter, nontoxic, cold in nature, has clearing summer heat, improving eyesight removing toxic substances, reducing pressure and sugar, diuresis removing heat from blood, separates that labor clears away heart-fire, effect of QI invigorating tonifying YANG, has cool, thirst-quenching, heat-clearing and toxic substances removing, the improving eyesight that clears away heart-fire, QI invigorating recover from fatigue, the effect of kidney tonifying diuresis.Fructus psidii guajavae immaturus is warm in nature, sweet in the mouth, puckery, sour, nontoxic, has spleen invigorating removing food stagnancy; Effect of relieving diarrhea with astringents, staple food amasss glutted; Infantile malnutrition; Diarrhoea; Dysentery; Proctoptosis; Metrorrhagia.Astringent therapy antidiarrheal; Pain relieving sore.Main dysentery; Epigastric pain; Toothache; Diabetes; Skin infection; Venom.Radix Rehmanniae sweet in the mouth, cold in nature, for consumption of YIN caused by febrile disease, crimson tongue excessive thirst, sends out speckle dermexanthesis, spits blood, epistaxis, laryngopharynx swelling and pain.Radix Rehmanniae clearing away heat and cooling blood, yin nourishing, promotes the production of body fluid.For calentura crimson tongue excessive thirst, yin asthenia generating intrinsic heat, hectic fever due to YIN-deficiency consumptive fever, interior-heat is quenched one's thirst, and spits blood, and epistaxis sends out speckle dermexanthesis.Fructus Ligustri Lucidi sweet in the mouth, hardship, cool in nature, have liver and kidney tonifying, improving eyesight, effect of clearind deficient heat, cures mainly, and has a dizzy spell, early whitening of beard and hair, blurring of vision, fever due to yin deficiency.Rhizoma Polygonati Odorati sweet in the mouth, cold nature.Enter lung, stomach warp, there is yin nourishing, moisturize, relieving restlessness, the effect of quenching the thirst, control consumption of YIN caused by febrile disease, cough excessive thirst, deficient fever, rapid digestion of food easily famine, frequent micturition etc.Radix Asparagi sweetness and bitterness, cold in nature, there is YIN nourishing, moisturize, lung heat clearing, effect of pathogenic fire reducing.Primary treatment fever due to yin deficiency, cough is spitted blood, and consumptive lung disease, lung abscess, laryngopharynx swelling and pain, quenches one's thirst, constipation.Gypsum Fibrosum, the property of medicine is sweet, pungent, Great Cold, and control sky capable fanatic, wind syndrome of head revolves, stimulating milk secretion, wipes tooth benefit tooth.Except gastric heat lung-heat, loose YIN pathogen, slow spleen QI invigorating.Only Yangming Channel headache, fever with chills, day feeds hectic fever, and drinking a large amount of water due to extreme thirst, heatstroke hectic fever, has a toothache.Poria sweet in the mouth, light, property is put down, and has promoting diuresis to eliminate damp pathogen, spleen invigorating, effect of mind calming, and for edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in loose stool, irritability, palpitation with fear insomnia.Cortex Lycii sweet in the mouth, cold in nature, have removing heat from blood except steaming, effect of lung heat clearing pathogenic fire reducing, for deficiency of YIN hectic fever, hectic fever due to YIN-deficiency night sweat, cough due to lung-heat, spitting of blood, epistaxis, interior-heat is quenched one's thirst.Radix Ophiopogonis is cold in nature, sweet in the mouth, enters lung, the heart, stomach warp, has heat-clearing and toxic substances removing, antiinflammatory, tonify deficiency treat effect of wind, cures mainly disease under distension, epidemic febrile disease heating, the diseases such as pyretic toxicity carbuncle and ulcer and tumor.Flos Eriocauli acrid in the mouth, sweet, property is put down, and has dispelling wind and heat pathogens, tomorrow nebula removing effect, for wind heat conjunctival congestion, swell and ache photophobia, nebula of looking unfamiliar film, headache due to pathogenic wind-heat.Rhizoma Dioscoreae has and nourishes strong, aid digestion, hold back sweating due to debility, effect of antidiarrheal, cure mainly insufficiency of the spleen diarrhoea, cough due to deficiency of the lung, diabetes are quenched one's thirst, oliguria frequently, seminal emission, women's leukorrhagia and dyspeptic chronic enteritis.Pericarpium Citri acrid in the mouth, micro-hardship, acid, warm in nature, liver-smoothing, qi-regulating, alleviating distention in middle-JIAO, reduces phlegm, and for stagnation of liver-QI and stomach-QI, distending pain in the chest and hypochondrium, gastral cavity abdomen feeling of fullness, vomiting eructation, abundant expectoration is coughed.Cortex Magnoliae Officinalis acrid in the mouth, warm in nature, there is circulation of qi promoting removing dampness, warming middle-JIAO to relieve pain, lowering the adverse QI to relieve asthma, relieving dyspepsia expectorant, wind dispelling analgesic effect.Radix Paeoniae Rubra bitter in the mouth, cold nature, has clearing away heat and cooling blood, effect of eliminating stasis to stop pain, and for thermal man's nutrient blood, maculae caused by violent heat pathogen, hematemesis and epistaxis, conjunctival congestion and swelling pain, hypochondriac pain due to stagnation of liverQI, amenorrhea dysmenorrhea, addiction abdominal mass is suffered from abdominal pain, injury from falling down, carbuncle skin infection.Herba Lycopi is bitter, pungent, and tepor, has promoting blood flow to regulate menstruation, blood stasis dispelling eliminating carbuncle, effect of inducing diuresis to remove edema, and for menoxenia, amenorrhea, dysmenorrhea, postnatal blood stasis is suffered from abdominal pain, sore and toxic, edema ascites.Ramulus Euonymi bitter in the mouth, cold in nature, have removing blood stasis, stimulate the menstrual flow, effect of parasite killing, controls amenorrhea, lump in the abdomen, the stagnant stomachache of the stasis of blood in puerperal, abdominal pain due to worm stagnation.Rhizoma Sparganii acrid in the mouth, hardship, property is put down, for lump in the abdomen mass in the abdomen, dysmenorrhea, blood stasis amenorrhea, obstruction of qi in the chest and cardialgia, food stagnation distending pain.

The present invention has following beneficial effect:

(1) Galla Chinensis is astringed the lung pathogenic fire reducing, relieving diarrhea with astringents, arresting sweating, hemostasis, effect of removing dampness sore is monarch drug, Fructus Mori the liver and the kidney tonifying, intestine moistening of promoting the production of body fluid, black hair improving eyesight, Fructus Momordicae charantiae clearing summer heat, improving eyesight removing toxic substances, reducing pressure and sugar, diuresis removing heat from blood, separate labor clear away heart-fire, QI invigorating tonifying YANG, Fructus psidii guajavae immaturus spleen invigorating removing food stagnancy; Relieving diarrhea with astringents, Radix Rehmanniae consumption of YIN caused by febrile disease, crimson tongue excessive thirst, sends out speckle dermexanthesis, spits blood, epistaxis, laryngopharynx swelling and pain, Fructus Ligustri Lucidi liver and kidney tonifying, improving eyesight, effect of clearind deficient heat, Rhizoma Polygonati Odorati yin nourishing, moisturizes, relieving restlessness, to quench the thirst, and Radix Asparagi YIN nourishing, moisturizes, lung heat clearing, pathogenic fire reducing.Fructus Mori, Fructus Momordicae charantiae, Fructus psidii guajavae immaturus, the Radix Rehmanniae, Fructus Ligustri Lucidi, Rhizoma Polygonati Odorati, Radix Asparagi are ministerial drug, can make to be more preferably monarch drug to astringe the lung pathogenic fire reducing, and the promoting the production of body fluid to quench thirst that interacts, the liver and the kidney tonifying, nourishing YIN is empty, and ministerial drug has the effect of spleen invigorating removing food stagnancy, the glucose that health is unnecessary can be consumed, prevent the generation of diabetes consecutive complications.

Gypsum Fibrosum is except gastric heat lung-heat, and loose YIN pathogen, delays spleen QI invigorating, and only day feeds hectic fever, drinking a large amount of water due to extreme thirst; Poria promoting diuresis to eliminate damp pathogen, spleen invigorating, mind calming; Cortex Lycii removing heat from blood removes and steams, lung heat clearing pathogenic fire reducing; Radix Ophiopogonis heat-clearing and toxic substances removing, antiinflammatory, tonify deficiency treat wind; Flos Eriocauli dispelling wind and heat pathogens, tomorrow nebula removing; Rhizoma Dioscoreae nourishes strong, aid digestion, holds back sweating due to debility, antidiarrheal; Pericarpium Citri liver-smoothing, qi-regulating, alleviating distention in middle-JIAO, reduces phlegm.Gypsum Fibrosum, Poria, Cortex Lycii, Radix Ophiopogonis, Flos Eriocauli, Rhizoma Dioscoreae, Pericarpium Citri are adjuvant drug, effectively can assist the lung heat clearing pathogenic fire reducing of monarch drug, remove the deficiency of YIN scorching, and adjuvant drug has the effect of removing toxic substances antiinflammatory, liver-smoothing, qi-regulating, suppresses the generation of glycosuria disease complication like this.

Cortex Magnoliae Officinalis circulation of qi promoting removing dampness, warming middle-JIAO to relieve pain, lowering the adverse QI to relieve asthma, relieving dyspepsia expectorant, wind dispelling analgesia, Radix Paeoniae Rubra clearing away heat and cooling blood, eliminating stasis to stop pain, Herba Lycopi's promoting blood flow to regulate menstruation, blood stasis dispelling eliminating carbuncle, inducing diuresis to remove edema, Ramulus Euonymi removing blood stasis, stimulates the menstrual flow, parasite killing, Rhizoma Sparganii taste lump in the abdomen mass in the abdomen, dysmenorrhea, blood stasis amenorrhea, obstruction of qi in the chest and cardialgia, food stagnation distending pain, Cortex Magnoliae Officinalis, Radix Paeoniae Rubra, Herba Lycopi, Ramulus Euonymi, Rhizoma Sparganii, can effective circulation of qi promoting removing dampness for making medicine, relieving dyspepsia expectorant, eliminating stasis to stop pain, blood stasis amenorrhea, solves the problem of blood stasis amenorrhea.

(2) first a period of time is soaked by purified water, medical material deliquescing, cell expansion before decoction, effective ingredient is easily fried, and medical material contains starch, protein, after soaking, prevent when decocting, the starch gelatinization on medical material surface, protein coagulating, the capillary channel on blocking medical material surface, makes the moisture when decocting enter not go, effective ingredient is not easily fried, affects curative effect of medication; Decoction can change the irritation effect of medicine, relatively mildly acts on skin, promotes the absorption of medicine; Supercritical extraction, immersion, concentration step retain the effective ingredient in Chinese medicine of the present invention to greatest extent, make the object that tablet reaches refining.

Detailed description of the invention

Below in conjunction with embodiment, the present invention is further elaborated.

Embodiment 1:

Treat a Chinese medicinal tablet for diabetes, the crude drug effective ingredient mass fraction making tablet comprises: Galla Chinensis 20 parts, Fructus Mori 9 parts, 14 parts, Fructus Momordicae charantiae, Fructus psidii guajavae immaturus 10 parts, 6 parts, the Radix Rehmanniae, Fructus Ligustri Lucidi 17 parts, Rhizoma Polygonati Odorati 8 parts, Radix Asparagi 10 parts, Gypsum Fibrosum 7 parts, 12 parts, Poria, Cortex Lycii 10 parts, Radix Ophiopogonis 15 parts, Flos Eriocauli 5 parts, Rhizoma Dioscoreae 10 parts, Pericarpium Citri 5 parts, Cortex Magnoliae Officinalis 8 parts, Radix Paeoniae Rubra 17 parts, Herba Lycopi 7 parts, Ramulus Euonymi 10 parts, Rhizoma Sparganii 12 parts.

A kind of preparation method for the treatment of the Chinese medicinal tablet of diabetes:

(1) soak: take each raw material by above-mentioned mass fraction, gross weight is designated as 1 part, adds 6 parts of purified water, 50 DEG C are soaked 1h, obtain soak;

(2) decoct: after the soak that step (1) obtains being heated to boiling, boil 2h, be separated and take out fried liquid, continue the purified water adding 4 parts in medical material, continue to boil 1.5h after being heated to boiling, merge twice fried liquid and be extracting solution;

(3) supercritical extraction: the extracting solution that step (2) obtains is positioned in the extraction kettle in supercritical extraction instrument, carbon dioxide is utilized to extract as medium, extraction kettle pressure is 40Mpa, extraction temperature is 45 DEG C, separator pressure 12Mpa, separator temperature is 70 DEG C, extracts 2 hours, is extracted liquid;

(4) concentrated: extract step (3) obtained concentrates at outer circulation concentrator, and concentrated condition is: pressure 0.03Mpa, temperature 70 C, is concentrated into the extractum that relative density is 1.13;

(5) by extractum obtained for step (4) and the starch or the Icing Sugar Homogeneous phase mixing that account for extractum gross mass 10%, cross 16 mesh sieves and make wet grain, grain will be wet in 50 DEG C of dryings, with 16 mesh sieve granulate, add the magnesium stearate accounting for medicine gross mass 1%, mixing, is pressed into tablet with tablet machine, every sheet 0.8 gram.

Embodiment 2:

Treat a Chinese medicinal tablet for diabetes, the crude drug effective ingredient mass fraction making tablet comprises: Galla Chinensis 35 parts, Fructus Mori 21 parts, 28 parts, Fructus Momordicae charantiae, Fructus psidii guajavae immaturus 25 parts, 18 parts, the Radix Rehmanniae, Fructus Ligustri Lucidi 29 parts, Rhizoma Polygonati Odorati 26 parts, Radix Asparagi 21 parts, Gypsum Fibrosum 22 parts, 27 parts, Poria, Cortex Lycii 24 parts, Radix Ophiopogonis 35 parts, Flos Eriocauli 25 parts, Rhizoma Dioscoreae 30 parts, Pericarpium Citri 25 parts, Cortex Magnoliae Officinalis 26 parts, Radix Paeoniae Rubra 31 parts, Herba Lycopi 22 parts, Ramulus Euonymi 25 parts, Rhizoma Sparganii 27 parts.

A kind of Chinese medicinal tablet preparation method for the treatment of diabetes:

(1) soak: take each raw material by above-mentioned mass fraction, gross weight is designated as 1 part, adds 6 parts of purified water, 50 DEG C are soaked 1h, obtain soak;

(2) decoct: after the soak that step (1) obtains being heated to boiling, boil 2h, be separated and take out fried liquid, continue the purified water adding 4 parts in medical material, continue to boil 1.5h after being heated to boiling, merge twice fried liquid and be extracting solution;

(3) supercritical extraction: the extracting solution that step (2) obtains is positioned in the extraction kettle in supercritical extraction instrument, carbon dioxide is utilized to extract as medium, extraction kettle pressure is 40Mpa, extraction temperature is 45 DEG C, separator pressure 12Mpa, separator temperature is 70 DEG C, extracts 2 hours, is extracted liquid;

(4) concentrated: extract step (3) obtained concentrates at outer circulation concentrator, and concentrated condition is: pressure 0.03Mpa, temperature 70 C, is concentrated into the extractum that relative density is 1.13;

(5) by extractum obtained for step (4) and the starch or the Icing Sugar Homogeneous phase mixing that account for extractum gross mass 10%, cross 16 mesh sieves and make wet grain, grain will be wet in 50 DEG C of dryings, with 16 mesh sieve granulate, add the magnesium stearate accounting for medicine gross mass 1%, mixing, is pressed into tablet with tablet machine, every sheet 0.8 gram.

Embodiment 3:

Treat a Chinese medicinal tablet for diabetes, the crude drug effective ingredient mass fraction making tablet comprises: Galla Chinensis 25 parts, Fructus Mori 14 parts, 19 parts, Fructus Momordicae charantiae, Fructus psidii guajavae immaturus 15 parts, 11 parts, the Radix Rehmanniae, Fructus Ligustri Lucidi 21 parts, Rhizoma Polygonati Odorati 13 parts, Radix Asparagi 15 parts, Gypsum Fibrosum 15 parts, 17 parts, Poria, Cortex Lycii 15 parts, Radix Ophiopogonis 20 parts, Flos Eriocauli 10 parts, Rhizoma Dioscoreae 15 parts, Pericarpium Citri 10 parts, Cortex Magnoliae Officinalis 13 parts, Radix Paeoniae Rubra 22 parts, Herba Lycopi 12 parts, Ramulus Euonymi 15 parts, Rhizoma Sparganii 17 parts.

A kind of preparation method for the treatment of the Chinese medicinal tablet of diabetes:

(1) soak: take each raw material by above-mentioned mass fraction, gross weight is designated as 1 part, adds 6 parts of purified water, 50 DEG C are soaked 1h, obtain soak;

(2) decoct: after the soak that step (1) obtains being heated to boiling, boil 2h, be separated and take out fried liquid, continue the purified water adding 4 parts in medical material, continue to boil 1.5h after being heated to boiling, merge twice fried liquid and be extracting solution;

(3) supercritical extraction: the extracting solution that step (2) obtains is positioned in the extraction kettle in supercritical extraction instrument, carbon dioxide is utilized to extract as medium, extraction kettle pressure is 40Mpa, extraction temperature is 45 DEG C, separator pressure 12Mpa, separator temperature is 70 DEG C, extracts 2 hours, is extracted liquid;

(4) concentrated: extract step (3) obtained concentrates at outer circulation concentrator, and concentrated condition is: pressure 0.03Mpa, temperature 70 C, is concentrated into the extractum that relative density is 1.13;

(5) by extractum obtained for step (4) and the starch or the Icing Sugar Homogeneous phase mixing that account for extractum gross mass 10%, cross 16 mesh sieves and make wet grain, grain will be wet in 50 DEG C of dryings, with 16 mesh sieve granulate, add the magnesium stearate accounting for medicine gross mass 1%, mixing, is pressed into tablet with tablet machine, every sheet 0.8 gram.

Embodiment 4:

Treat a Chinese medicinal tablet for diabetes, the crude drug effective ingredient mass fraction making tablet comprises: Galla Chinensis 30 parts, Fructus Mori 17 parts, 23 parts, Fructus Momordicae charantiae, Fructus psidii guajavae immaturus 20 parts, 13 parts, the Radix Rehmanniae, Fructus Ligustri Lucidi 24 parts, Rhizoma Polygonati Odorati 21 parts, Radix Asparagi 18 parts, Gypsum Fibrosum 18 parts, 22 parts, Poria, Cortex Lycii 19 parts, Radix Ophiopogonis 30 parts, Flos Eriocauli 20 parts, Rhizoma Dioscoreae 25 parts, Pericarpium Citri 20 parts, Cortex Magnoliae Officinalis 21 parts, Radix Paeoniae Rubra 27 parts, Herba Lycopi 17 parts, Ramulus Euonymi 20 parts, Rhizoma Sparganii 22 parts.

A kind of preparation method for the treatment of the Chinese medicinal tablet of diabetes:

(1) soak: take each raw material by above-mentioned mass fraction, gross weight is designated as 1 part, adds 6 parts of purified water, 50 DEG C are soaked 1h, obtain soak;

(2) decoct: after the soak that step (1) obtains being heated to boiling, boil 2h, be separated and take out fried liquid, continue the purified water adding 4 parts in medical material, continue to boil 1.5h after being heated to boiling, merge twice fried liquid and be extracting solution;

(3) supercritical extraction: the extracting solution that step (2) obtains is positioned in the extraction kettle in supercritical extraction instrument, carbon dioxide is utilized to extract as medium, extraction kettle pressure is 40Mpa, extraction temperature is 45 DEG C, separator pressure 12Mpa, separator temperature is 70 DEG C, extracts 2 hours, is extracted liquid;

(4) concentrated: extract step (3) obtained concentrates at outer circulation concentrator, and concentrated condition is: pressure 0.03Mpa, temperature 70 C, is concentrated into the extractum that relative density is 1.13;

(5) by extractum obtained for step (4) and the starch or the Icing Sugar Homogeneous phase mixing that account for extractum gross mass 10%, cross 16 mesh sieves and make wet grain, grain will be wet in 50 DEG C of dryings, with 16 mesh sieve granulate, add the magnesium stearate accounting for medicine gross mass 1%, mixing, is pressed into tablet with tablet machine, every sheet 0.8 gram.

Embodiment 5:

Treat a Chinese medicinal tablet for diabetes, the crude drug effective ingredient mass fraction making tablet comprises: Galla Chinensis 27 parts, Fructus Mori 16 parts, 21 parts, Fructus Momordicae charantiae, Fructus psidii guajavae immaturus 17 parts, 12 parts, the Radix Rehmanniae, Fructus Ligustri Lucidi 22 parts, Rhizoma Polygonati Odorati 17 parts, Radix Asparagi 17 parts, Gypsum Fibrosum 16 parts, 20 parts, Poria, Cortex Lycii 17 parts, Radix Ophiopogonis 25 parts, Flos Eriocauli 25 parts, Rhizoma Dioscoreae 20 parts, Pericarpium Citri 15 parts, Cortex Magnoliae Officinalis 17 parts, Radix Paeoniae Rubra 24 parts, Herba Lycopi 14 parts, Ramulus Euonymi 17 parts, Rhizoma Sparganii 20 parts.

A kind of preparation method for the treatment of the Chinese medicinal tablet of diabetes:

(1) soak: take each raw material by above-mentioned mass fraction, gross weight is designated as 1 part, adds 6 parts of purified water, 50 DEG C are soaked 1h, obtain soak;

(2) decoct: after the soak that step (1) obtains being heated to boiling, boil 2h, be separated and take out fried liquid, continue the purified water adding 4 parts in medical material, continue to boil 1.5h after being heated to boiling, merge twice fried liquid and be extracting solution;

(3) supercritical extraction: the extracting solution that step (2) obtains is positioned in the extraction kettle in supercritical extraction instrument, carbon dioxide is utilized to extract as medium, extraction kettle pressure is 40Mpa, extraction temperature is 45 DEG C, separator pressure 12Mpa, separator temperature is 70 DEG C, extracts 2 hours, is extracted liquid;

(4) concentrated: extract step (3) obtained concentrates at outer circulation concentrator, and concentrated condition is: pressure 0.03Mpa, temperature 70 C, is concentrated into the extractum that relative density is 1.13;

(5) by extractum obtained for step (4) and the starch or the Icing Sugar Homogeneous phase mixing that account for extractum gross mass 10%, cross 16 mesh sieves and make wet grain, grain will be wet in 50 DEG C of dryings, with 16 mesh sieve granulate, add the magnesium stearate accounting for medicine gross mass 1%, mixing, is pressed into tablet with tablet machine, every sheet 0.8 gram.

1, zoopery

Animal acute toxicity experiment, selects white mice 40, each 20 of male and female, sodium carboxymethyl cellulose solution with 1% makes the suspension of 50mg/ml, gavage body 0.56ml/10g, every day three times, observe animal activity after gavage 15 days, diet, feces, hair color and death condition, the results are shown in Table 1.

Animal acute toxicity experiment result:

Table 1

After experimental result gavage, the diet of animal, feces, none example of hair are abnormal, and after second, third gavage, much more slightly animal moves, and within about 10 minutes, the many emotionally conditions of animal disappear, and none example was dead on 15th.

Conclusion: maximum tolerated dose is ﹥ 7.35mg/kg is 147 times of the clinical maximal dose of people.

2, pharmacodynamic analysis of the present invention

By Wistar rat totally 20 fasting 12h, by 60mg/kg body weight lumbar injection Streptozocin (STZ) 1 time, and give high-calorie feed raising 12 weeks, successfully prepare animal model of diabetes mellitus type II, have that overweight, impaired glucose tolerance, blood fat raise, serum insulin raises and combination rate of insulin receptor reduces the feature of companion's insulin resistant, be similar to the Clinical symptoms of Patients with NIDDM.Type Ⅱdiabetes mellitus Mus stochastic averagina is divided into 2 groups, is respectively positive controls, test group.Positive controls gastric infusion metformin quick releasing formulation, 3 times on the 1st.Test group gastric infusion Chinese medicinal tablet of the present invention, 3 times on the 1st.Get blood morning every day and survey fasting blood sugar, continuous detecting 10 days.

Blood sugar test: tail venous blood sampling, 3000rpm × 10min, separation of serum, uses determination of glucose oxidase blood glucose value, and average blood sugar value the results are shown in Table 3.

Table 3

Conclusion: Chinese medicinal tablet hypoglycemic effect of the present invention is faster, is better than matched group.

3, clinical data and case:

In order to show therapeutic effect of the present invention, system clinical observation treatment being carried out to 100 routine diabeticss, in the process of above-mentioned clinical observation, record being carried out to the medical history of above-mentioned patient, the state of an illness and curative effect.

Clinical therapeutic efficacy criterion is:

Take a turn for the better: common sympton polyuria, polydipsia, easy hungry polyphagia, become thin, xerostomia is weak, gingivitis repeatedly, urinary tract infection etc. disappear substantially.

Invalid: symptom is not improved.

Therapeutic effect: the present invention is through treating 100 routine diabeticss, and 98 examples take a turn for the better, and 2 examples are invalid, and total effective rate reaches 98%, and nobody occurs side effect.

Model case:

Case 1: patient Jiang so-and-so, man, 59 years old, patient's polyuria, polydipsia, easy hungry polyphagia, become thin, xerostomia is weak, gingivitis repeatedly, urinary tract infection, after using 1 course for the treatment of of Chinese medicinal tablet of the present invention, symptom obviously alleviates, and continue 1 course for the treatment of of use, symptom all disappears.

Case 2: patient Lee, man, 77 years old, patient's polyuria, polydipsia, easy hungry polyphagia, become thin, xerostomia is weak, gingivitis repeatedly, urinary tract infection, after using 2 courses for the treatment of of Chinese medicinal tablet of the present invention, symptom is obviously improved, 2 courses for the treatment of of continuation use, and symptom all disappears.

Case 3: patient Jiang, female, 67 years old, patient's polyuria, polydipsia, easy hungry polyphagia, become thin, xerostomia is weak, gingivitis repeatedly, urinary tract infection, after using 1 course for the treatment of of Chinese medicinal tablet of the present invention, symptom is clearly better, and after continuing to use 2 courses for the treatment of of Chinese medicinal tablet of the present invention, symptom all disappears.

The above is the preferred embodiment of the present invention; its object is to allow person skilled in the art understand content of the present invention and to be implemented; should be understood that; for those skilled in the art; under the premise without departing from the principles of the invention; can also make some improvements and modifications, these improvements and modifications are also considered as protection scope of the present invention.

Claims (4)

1. treat the Chinese medicinal tablet of diabetes for one kind, it is characterized in that, the effective ingredient mass fraction making tablet comprises: Galla Chinensis 20 ~ 35 parts, Fructus Mori 9 ~ 21 parts, 14 ~ 28 parts, Fructus Momordicae charantiae, Fructus psidii guajavae immaturus 10 ~ 25 parts, 6 ~ 18 parts, the Radix Rehmanniae, Fructus Ligustri Lucidi 17 ~ 29 parts, Rhizoma Polygonati Odorati 8 ~ 26 parts, Radix Asparagi 10 ~ 21 parts, Gypsum Fibrosum 7 ~ 22 parts, 12 ~ 27 parts, Poria, Cortex Lycii 10 ~ 24 parts, Radix Ophiopogonis 15 ~ 35 parts, Flos Eriocauli 5 ~ 25 parts, Rhizoma Dioscoreae 10 ~ 30 parts, Pericarpium Citri 5 ~ 25 parts, Cortex Magnoliae Officinalis 8 ~ 26 parts, Radix Paeoniae Rubra 17 ~ 31 parts, Herba Lycopi 7 ~ 22 parts, Ramulus Euonymi 10 ~ 25 parts, Rhizoma Sparganii 12 ~ 27 parts.

2. a kind of Chinese medicinal tablet for the treatment of diabetes according to claim 1, it is characterized in that, the effective ingredient mass fraction making tablet comprises: Galla Chinensis 25 ~ 30 parts, Fructus Mori 14 ~ 17 parts, 19 ~ 23 parts, Fructus Momordicae charantiae, Fructus psidii guajavae immaturus 15 ~ 20 parts, 11 ~ 13 parts, the Radix Rehmanniae, Fructus Ligustri Lucidi 21 ~ 24 parts, Rhizoma Polygonati Odorati 13 ~ 21 parts, Radix Asparagi 15 ~ 18 parts, Gypsum Fibrosum 15 ~ 18 parts, 17 ~ 22 parts, Poria, Cortex Lycii 15 ~ 19 parts, Radix Ophiopogonis 20 ~ 30 parts, Flos Eriocauli 10 ~ 20 parts, Rhizoma Dioscoreae 15 ~ 25 parts, Pericarpium Citri 10 ~ 20 parts, Cortex Magnoliae Officinalis 13 ~ 21 parts, Radix Paeoniae Rubra 22 ~ 27 parts, Herba Lycopi 12 ~ 17 parts, Ramulus Euonymi 15 ~ 20 parts, Rhizoma Sparganii 17 ~ 22 parts.

3. a kind of Chinese medicinal tablet for the treatment of diabetes according to claim 1, it is characterized in that, the effective ingredient mass fraction making tablet comprises: Galla Chinensis 27 parts, Fructus Mori 16 parts, 21 parts, Fructus Momordicae charantiae, Fructus psidii guajavae immaturus 17 parts, 12 parts, the Radix Rehmanniae, Fructus Ligustri Lucidi 22 parts, Rhizoma Polygonati Odorati 17 parts, Radix Asparagi 17 parts, Gypsum Fibrosum 16 parts, 20 parts, Poria, Cortex Lycii 17 parts, Radix Ophiopogonis 25 parts, Flos Eriocauli 25 parts, Rhizoma Dioscoreae 20 parts, Pericarpium Citri 15 parts, Cortex Magnoliae Officinalis 17 parts, Radix Paeoniae Rubra 24 parts, Herba Lycopi 14 parts, Ramulus Euonymi 17 parts, Rhizoma Sparganii 20 parts.

4. treat a preparation method for the Chinese medicinal tablet of diabetes, it is characterized in that, described preparation method concrete steps are as follows:

(1) soak: take each raw material by above-mentioned mass fraction, gross weight is designated as 1 part, adds 6 parts of purified water, 50 DEG C are soaked 1h, obtain soak;

(2) decoct: after the soak that step (1) obtains being heated to boiling, boil 2h, be separated and take out fried liquid, continue the purified water adding 4 parts in medical material, continue to boil 1.5h after being heated to boiling, merge twice fried liquid and be extracting solution;

(3) supercritical extraction: the extracting solution that step (2) obtains is positioned in the extraction kettle in supercritical extraction instrument, carbon dioxide is utilized to extract as medium, extraction kettle pressure is 40Mpa, extraction temperature is 45 DEG C, separator pressure 12Mpa, separator temperature is 70 DEG C, extracts 2 hours, is extracted liquid;

(4) concentrated: extract step (3) obtained concentrates at outer circulation concentrator, and concentrated condition is: pressure 0.03Mpa, temperature 70 C, is concentrated into the extractum that relative density is 1.13;

(5) by extractum obtained for step (4) and the starch or the Icing Sugar Homogeneous phase mixing that account for extractum gross mass 10%, cross 16 mesh sieves and make wet grain, grain will be wet in 50 DEG C of dryings, with 16 mesh sieve granulate, add the magnesium stearate accounting for medicine gross mass 1%, mixing, is pressed into tablet with tablet machine, every sheet 0.8 gram.