CN105963514A - Traditional Chinese medicine product for treating diabetes and preparation method - Google Patents
Traditional Chinese medicine product for treating diabetes and preparation method Download PDFInfo
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- CN105963514A CN105963514A CN201610347990.5A CN201610347990A CN105963514A CN 105963514 A CN105963514 A CN 105963514A CN 201610347990 A CN201610347990 A CN 201610347990A CN 105963514 A CN105963514 A CN 105963514A
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Abstract
The invention discloses a traditional Chinese medicine product for treating diabetes and a preparation method. The traditional Chinese medicine product is prepared from massive common traditional Chinese medicine materials, and the purpose of reducing blood glucose and relieving, stabilizing and treating diabetes can be achieved. On the basis of excavating ancient prescriptions, new flooring proved recipes are added, and the traditional Chinese medicine product becomes a novel breakthrough point in the medical history of treating diabetes. The traditional Chinese medicine product comprises the following substances in parts by weight: 12-15 parts of lycium barbarum roots, 8-12 parts of rehmannia glutinosa libosch, 8-13 parts of radix polygonati officinalis, 12-20 parts of astragalus membranaceus, 5-9 parts of rhizoma polygonati, 15-18 parts of the root of kudzu vine, 20-25 parts of chinese yam, 8-15 parts of bitter gourd, 10-15 parts of radix ophiopogonis, 10-12 parts of lycium barbarum, 12-15 parts of black tartary buckwheat, 15-18 parts of potentilla discolor, 3-6 parts of folium mori, 1-5 parts of chromium picolinate and 3-5 parts of chromium-enriched yeast.
Description
Technical field
The invention belongs to technical field of Chinese medicines, particularly relate to a kind of Chinese medicine product treating diabetes and preparation method.
Background technology
In recent years, the living standard of the people improves constantly, the modern life makes the activity of people greatly decline, as taken a bus instead of walking, replace ascending a height with elevator, housework etc. is replaced with household electrical appliance, most people lacks custom and the condition participating in physical training, quantity of motion deficiency not only reduces the resistance against diseases of body, the transhipment of the glucose inside cells that also can slow down, and reduces oxidation and the utilization rate of MUSCLE GLUCOSE, and the sensitivity that body is to insulin, adding irrational dietary structure and cause people's body overnutrition, endocrine function is lacked of proper care, and seriously induces diabetes.At present, diabetes become the third-largest killer of human health, while lethal disability rate rapidly rises, domestic medical industry traditional Chinese medical science westernization, Western medicine is eaten more and more, and the state of an illness is controlled heavier and heavier, and insulin is widely used injection, constantly dosage, operative treatment makes sickness rate, disability rate, mortality rate constantly rise, and many patients among the people constantly seek folk prescription while western medicine, proved recipe, secret recipe, folk prescription use and suit the remedy to the case, determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, have little effect, cause the treatment by Chinese herbs time the veryest long.
Therefore, be badly in need of have developed a kind of low cost, technique is simple, have no side effect, and with plurality of Chinese composition synergism, can dissolve the herbal mixture goods of the generation utilizing sugar to eliminate and to control diabetic complication with long-term taking.
Summary of the invention
The invention aims to solve the deficiency that above-mentioned technical problem exists, one is provided to treat Chinese medicine for treating diabetes goods and preparation method, the present invention has drawn from common Chinese material and extract thereof widely, reduce blood glucose, alleviate, stablize, treat the purpose of diabetes, the present invention adds new ground material proved recipe on the basis of excavating ancient prescription, becomes new breakthrough point in the medical history for the treatment of diabetes.
To achieve these goals, the present invention is to realize by the following technical solutions:
A kind of Chinese medicine product treating diabetes, including the material of following parts by weight: boxthorn root 12-15 part, cherishes Radix Rehmanniae 8-12 part, Rhizoma Polygonati Odorati 8-13 part, Radix Astragali 12-20 part, Rhizoma Polygonati 5-9 part, Radix Puerariae 15-18 part, RHIIZOMA DIOSCOREAE fr0m Henan of China 20-25 part, Fructus Momordicae charantiae 8-15 part, Radix Ophiopogonis 10-15 part, Fructus Lycii 10-12 part, Black Radix Et Rhizoma Fagopyri Tatarici 12-15 part, Herba Potentillae Discoloris 15-18 part, winter folium mori 3-6 part, chromium picolinate 1-5 part, Rich chromium yeast 3-5 part.
Described Rhizoma Dioscoreae, Radix Rehmanniae use the RHIIZOMA DIOSCOREAE fr0m Henan of China in " four-Huai medicine ", bosom Radix Rehmanniae, and Folium Mori use winter folium mori.
Described Herba Potentillae Discoloris, boxthorn root select wild plant.
The preparation method of the Chinese medicine product of this treatment diabetes of the present invention is:
Step one, it is chosen for boxthorn root 12-15 part, bosom Radix Rehmanniae 8-12 part, Rhizoma Polygonati Odorati 8-13 part, Radix Astragali 12-20 part, Rhizoma Polygonati 5-9 part, Radix Puerariae 15-18 part, this seven tastes Chinese medicine of RHIIZOMA DIOSCOREAE fr0m Henan of China 20-25 part, it is carried out, is placed on natural air drying in net bed, put into grinder and be ground 2-3 hour, obtaining this seven tastes Chinese medicine mixed-powder, the powder size after grinding is a size of in 0.1 μm-10 μm, 1 in 0.044mm-0.074mm, 0.074-1mm or the grain size intervals of more than 1；
Step 2, choose Fructus Momordicae charantiae 8-15 part, Radix Ophiopogonis 10-15 part, Fructus Lycii 10-12 part, this four tastes Chinese medicine of Black Radix Et Rhizoma Fagopyri Tatarici 12-15 part, it is carried out, add little molecular energy water and boil 1-2h, next mixture is cooled down, fried juice is filtered by the nylon mesh of 50 μm, filtrate carries out separating 2～3 times in centrifuge, then 10min collects supernatant liquid every time, it is centrifuged separating until not having precipitate to separate out collecting liquid, united extraction liquid, by extracting solution through cold drying, concentrate, obtain viscous mixture, under temperature 100-150 degree, it is dried, obtain solid mixture after drying, put into and carry out pulverizing 0.5-1 hour with pulverizer, obtain Fructus Momordicae charantiae, Radix Ophiopogonis, Fructus Lycii and Black Radix Et Rhizoma Fagopyri Tatarici concentrate hybrid particles；
Step 3, choose Herba Potentillae Discoloris 15-18 part, this two tastes Chinese medicine of winter folium mori 3-6 part, soak with the little molecular energy water of Herba Potentillae Discoloris and winter folium mori gross weight 1-2 times, soak 3-4 hour, stir 0.2-1 hour, carry out vibration of ultrasonic wave 20-30 minute, add alimentary acetic acid, be adjusted to pH value at 4-5, add the cellulase of the 1-10% of Herba Potentillae Discoloris and winter folium mori gross weight, it is sufficiently stirred for, putting into dry distillation reactor still, after heating, in still, product enters condenser along reactor upper pipe, cool down, through distillation, leach to obtain leachate；By leachate through cold drying, concentration, obtain viscous mixture, under temperature 100-150 degree, be dried, obtain solid mixture after drying, put into and carry out pulverizing 1-2 hour with pulverizer, obtain Herba Potentillae Discoloris and winter folium mori concentrates hybrid particles；
The Herba Potentillae Discoloris that Fructus Momordicae charantiae, Radix Ophiopogonis, Fructus Lycii and Black Radix Et Rhizoma Fagopyri Tatarici concentrate hybrid particles, step 3 obtains that step 4, the boxthorn root that step one is obtained, bosom Radix Rehmanniae, Rhizoma Polygonati Odorati, the Radix Astragali, Rhizoma Polygonati, Radix Puerariae, the mixed-powder of this seven tastes Chinese medicine of RHIIZOMA DIOSCOREAE fr0m Henan of China, step 2 obtain and winter folium mori concentrate the chromium picolinate of hybrid particles and 1-5 part; the Rich chromium yeast Rich chromium yeast mixing of 3-5 part; after mix homogeneously, it is packaged into capsule or pellet granule or tabletting finished product.
Wherein in steps in number be parts by weight.
Wherein the gross weight number of the present invention is 168 parts～188 parts.
Wherein during the preparation method of the present invention, the pharmacologic action of this prescription and useful water quality have much relations, unavailable tap water, mineral water, all use little molecular energy water in preparation method.
nullThis seven tastes Chinese medicine mixed-powder granularity after wherein grinding in step one is in 0.1 μm-10 μm，0.044mm-0.074mm、In 0.074-1mm 1 or the grain size intervals of more than 1，Owing to this seven tastes Chinese medicine is the hardest，The general broken cell wall that cannot break this seven tastes Chinese medicine completely，Because the dissolution of effective medicinal component needs guiding through several even dozens of cell wall in cell，And quite a few Cell Component can not pass cell wall，This part can only waste，Therefore intracellular effective ingredient cannot be made the most fully to discharge，The present invention reaches superfine powder by the way of grinding，Intracellular effective ingredient is made the most fully to discharge，Thus improve the bioavailability of medical material，And grind after this seven tastes Chinese medicine mixed-powder granularity the most tiny，It is more beneficial for human body medicine is absorbed.
The wherein thin succulence of coating in Fructus Momordicae charantiae, Radix Ophiopogonis, Fructus Lycii, this four taste of Black Radix Et Rhizoma Fagopyri Tatarici in step 2, the present invention utilize boil, filter, extraction process is extracted the medicinal ingredient of this four tastes Chinese medicine in juice, reconcentration, be dried, be ground into granule.
Owing to Herba Potentillae Discoloris and winter folium mori belong to herbal plant, Plant fiber is more, if retaining Plant fiber not only affect mouthfeel, and medicinal ingredient is difficult to overflow, therefore the step 3 of the present invention is soaked 3-4 hour, stir 0.2-1 hour, carry out vibration of ultrasonic wave 20-30 minute, it is in order to the cell wall of Herba Potentillae Discoloris and winter folium mori is broken, allows the medical substance within its release cells.Step 3 is wherein adjusted to pH value at 4-5, add the cellulase of the 1-10% of Paeonia suffruticosa blade gross weight, be in order to cellulase can break Herba Potentillae Discoloris and the structure of winter folium mori cell wall, Herba Potentillae Discoloris and the structure of dimension cell wall, make intracellular medicinal ingredient dissolve, thus reach the purpose extracted.
The using method of the present invention and explanation；This prescription is the health product made for primary raw material with boxthorn root, RHIIZOMA DIOSCOREAE fr0m Henan of China, bosom Radix Rehmanniae, Rhizoma Polygonati, Fructus Momordicae charantiae, Radix Puerariae, Folium Mori, the Radix Astragali, Rhizoma Polygonati Odorati, Herba Potentillae Discoloris, Radix Ophiopogonis, Fructus Lycii, Black Radix Et Rhizoma Fagopyri Tatarici, there is regulation blood glucose, regulation blood fat, stop the health care of complication, improve immunity.
[health care] regulation blood glucose, regulation blood fat, prevent complication, improve immunity.
[suitable population] high blood glucose person, Hyperlipidemia person, long-term taking Western medicine and the patient of insulin injection
[being not suitable for crowd] anemia of pregnant woman, children, adverse cardiac patient.
[storage method] wind sheltering is dried place, and room temperature preserves.
[instructions of taking and consumption]
Each capsule fills 0.4-0.5 gram, every day 2 times, each 2,20 minutes ante cibum, warm water delivery service；
Pellet granule, every day 2 times, each 1 gram, 20 minutes ante cibum, warm water delivery service；
Every is 0.6-0.7 gram, every day 2 times, each 2,20 minutes ante cibum, warm water delivery service.
The adaptation population of this prescription；
Polydipsia, polyphagia, polyuria and the diabetics of lose weight " three-many-one-little "；Long-term taking antidiabetic drug, Liver and kidney damages, the most jiggly diabetics of blood glucose；Developing immunity to drugs various Western medicine, multi-medicament share the diabetics that effect is bad；Glycemic control is preferable, but has developed complications or the unconspicuous diabetics of complication symptom；Glycemic control is preferable, but glycolated hemoglobin exception person；Diabetes merge the patient of cardiovascular and cerebrovascular disease；Diabetes compressibility dysfunction；The diabetics that kidney function test is the most up to standard；Body constitution void is lost, and often catches a cold, constipation, the diabetics of hypoimmunity；Numb limbs and tense tendons, skin pruritus, twinge, have the diabetics of formication；Blurred vision, has the diabetics of muscae volitantes shape；Tobacco and wine excessively, overweight, have the High-risk Group of Diabetes of household heredity factors；Long term injections insulin, the diabetics of continuous dosage.
Wherein boxthorn root；Boxthorn root has another name called the root bark that Cortex Lycii is Fructus Lycii, and " Shengji Zonglu " is recorded, and Cortex Lycii is drunk, and controls and quenches one's thirst, day and night frequent taking of water, normal urination.Modern pharmacological research: Cortex Lycii contains the derivant of guanidine, has hypoglycemic activity." Chinese medicine information " is reported: Cortex Lycii has reduction effect to mouse glucose and adrenal gland's disposition hyperglycemia, the infringement of diabetic rat model beta Cell of islet morphosis is had and certain alleviates effect, also there is blood fat reducing, hypotensive effect, its hypotensive effect is relevant with nervus centralis, may be for blocking SNE and direct vasodilator.
Wherein cherish Radix Rehmanniae；Radix Rehmanniae Preparata, Chinese medicine name has another name called Radix Rehmanniae Preparata, the Preparation process product of Radix Rehmanniae.Dihuang polysaccharide contained by Radix Rehmanniae Preparata has a significantly immunity antitumor activity, the most significant heart tonifying, diuresis, protect the liver, blood sugar lowering, anti-proliferate, exudation, antiinflammatory, antifungal, the effect such as anti-radiation.Radix Rehmanniae Preparata is that Radix Rehmanniae yellow wine is mixed vexed, shines the copy steamed, so effect is different, raw is used for heat clearing away YIN nourishing, and ripe is used for blood rearing interpolating kidney.Radix Rehmanniae Preparata has heart tonifying, diuresis, blood sugar lowering and rising peripheral leukocytes, strengthens the effects such as immunologic function.
Wherein Rhizoma Polygonati Odorati；There is blood sugar lowering, Adjust-blood lipid and lipoid peroxidization resistant, can obviously improve the glucose-lipid metabolism disorder of diabetes.The Hyperglycemia In Stz-induced Diabetic Rats causing glucose, alloxan also has inhibitory action.Serum glucose and triglyceride level, the increasing serum insulin level of mice after modeling can be reduced very significantly.Fragrant solomonseal rhizome polyoses can effectively treat the diabetes mice of alloxan induction.
The wherein Radix Astragali: all void of Radix Astragali energy tonifying five ZANG-organs, is the panacea of the five internal organs tracking, QI invigorating, promotes ability and the good medicine of resist the disease.The Radix Astragali contains 3-9g protein kinase B+Protein kinase C, and exchanging treating blood disorders sugar has assosting effect.Radix Astragali sweet in the mouth, slightly warm in nature, return liver, spleen, lung, kidney channel.There are benefiting QI for strengthening the superficies, arresting sweating admittedly to take off, hold in the palm skin ulcer granulation promoting, effect of inducing diuresis to remove edema.In traditional Chinese medical science Five elements theory, what spring was corresponding is liver, therefore, takes good care of irritability most important for the health preserving in spring.The effect of the Radix Astragali；1. strengthen immunologic function 2. and effect 3. enhancing body anoxia enduring and the stress ability 4. of interferon are promoted that organism metabolism 5. improves cardiac function 6. hypotensive effect 7. hepatoprotective effect 8. and regulates the anti-mattress of blood glucose 9. and antiviral effect 10. hormone-like effect.
Wherein Rhizoma Polygonati: boosting qi and nourishing yin, tonifying speen and tonifying kidney, lowering blood sugar and preventing thirst.Boosting qi and nourishing yin, spleen invigorating, lung moistening, kidney benefiting functions.For the disease such as treat weakness of the spleen and stomach, fatigue and asthenia, xerostomia lack of appetite, deficiency of the lung cough caused by dryness, asthenia of essence and blood, interior-heat are quenched one's thirst, notable for treatment diabetes curative effect.Rhizoma Polygonati sweet in the mouth is put down, and has effect of boosting qi and nourishing yin, tonifying speen and tonifying kidney.Containing compositions such as polysaccharide, aminoacid, lymphatic temperament, starch in Rhizoma Polygonati, there is the effect of blood fat reducing, blood pressure lowering, moreover it is possible to strengthen old people's cardio-pulmonary function, slow down aging.Because middle-aged and elderly people not only yang-energy is more weak, and cloudy liquid has deficiency more.Its property of Rhizoma Polygonati is gentle, and effect slowly, takes not only enriching spleen-QI but also tonifying spleen-yin for a long time, and also the lung moistening and production of body fluid promoting, kidney tonifying mend smart effect, and the side effect that may bring without the big product mending warm-dryness syndrome.
Wherein Radix Puerariae: heat clearing away of reducing internal heat, liver-protecting fat-dropping, lung moistening of quenching one's thirst.Modern medicine study shows, the isoflavonoid puerarin in Radix Puerariae has certain curative effect to hypertension, hyperlipidemia, hyperglycemia and cardiovascular and cerebrovascular disease.Natural blood sugar lowering product, prevent complication.Radix Puerariae total flavones and puerarin can improve the oxygen metabolism of cardiac muscle, and myocardial metabolism is produced beneficial effect, can expand blood vessel simultaneously, improve microcirculation, reduce vascular resistance, make blood flow increase, therefore available preventing and treating myocardial ischemia, myocardial infarction, arrhythmia, hypertension, the disease such as arteriosclerosis.
The wherein selection of Radix Puerariae: the tuber that Radix Puerariae is complete is cylinder, surface brown, the vertical wrinkle of tool, it is seen that hole skin and mark of fibrous root.Matter is solid.Commodity medical material mostly be cut sth. askew, the crosscutting or block sheet of rip cutting, differ in size, section is coarse, khaki, and may be seen indistinctly 1 to 3 layer of concentric loops, and fibroid is strong, slightly sees mealiness, feeble QI, and taste is micro-sweet.
Wherein RHIIZOMA DIOSCOREAE fr0m Henan of China: spleen reinforcing nourishing the stomach, the lung benefiting that promotes the production of body fluid, lowering blood sugar and preventing thirst.Strengthening the spleen and tonifying the lung, stomach reinforcing the kidney invigorating, benefit of reinforcing the kidney essence, hearing-improing and eyesight improving, help the five internal organs, bone and muscle strengthening, long will to calm the nerves, effect and the effect such as life lengthening.Liver and kidney tonifying, essence astringing and desertion stemming.Having diabetes effect, extract has obvious hypoglycemic activity.Rhizoma Dioscoreae is very wide at distribution in China, the most on sale.And RHIIZOMA DIOSCOREAE fr0m Henan of China only have Wen County, Jiaozhuo, Henan, Wuzhi, improve military, Qinyang area medical value the highest, become China Pharmaceutical, the first-selection of health products trade.The most just having: the title of " Huai Qingfu ", " four-Huai medicine " becomes the easy-to-sell goods of modern diseases medication.
Wherein Fructus Momordicae charantiae: glucokinin, has potent blood sugar reducing function: the improving eyesight that clears away heart-fire, QI invigorating kidney tonifying, heat clearing away are quenched one's thirst.Fructus Momordicae charantiae is rich in Charantin, 5HTP and several amino acids, vitamin, and Charantin is blood sugar lowering, blood fat reducing, antitumor, pre-preventing bone rarefaction, adjustment endocrine, antioxidation, antibacterial, the classical medicine of raising immunity.Good reputation that Charantin have to be had " fat killer ", to lipidemia, blood is viscous and cardiovascular and cerebrovascular vessel disease is effective.Fructus Momordicae charantiae has effect of clearing away heat and removing summer, nourishing blood and invigorating qi, kidney and spleen invigorating, nourishing liver for improving eyesight, and, heatstroke heating swollen to treatment dysentery, skin ulcer, miliaria are too much, conjunctivitis etc. is sick certain effect.The Vitamin C content of Fructus Momordicae charantiae is the highest, has the effect such as prevention vitamin C deficiency, protection cell membrane, atherosclerosis, raising physical stress ability, cardioprotection.Charantin in Fructus Momordicae charantiae is described as " fat killer " can be made to pinch and take fat and polysaccharide reduces.Charantin in Fructus Momordicae charantiae and bitter principle energy appetite stimulator, spleen benefiting and stimulating the appetite；Contained alkaloids substance quinine, has diuresis to invigorate blood circulation, anti-inflammatory antipyretic, the effect of the improving eyesight that clears away heart-fire；Reduce blood glucose.
Wherein Radix Ophiopogonis: YIN nourishing and the production of body fluid promoting, nourishing the lung to arrest cough: few thirsty, dry cough spitting of blood for Tianjin of lung-stomach yin deficiency；The palpitation and being susceptible to fright of insufficiency of heart-YIN and calentura later stage consumption of body fluid by heat etc. are demonstrate,proved.Radix Ophiopogonis cold nature, sweet and slightly bitter taste.Radix Ophiopogonis is containing compositions such as multiple steroid saponin, carotene, phlegmatic temperament, saccharide, stigmasterol.Pharmacological evaluation proves, Radix Ophiopogonis has leukocyte increasing, extends antibody and there is the effect of time, improves immunologic function and nucleic acid synthetic ratio, promotes that the immune materials such as antibody, complement, interferon, lysozyme produce.Therefore Radix Ophiopogonis has enhancing healthy energy, strengthens anti-evil effect, thus reduces the generation of disease.As described in Compendium of Material Medica " clothes are made light of one's life by commiting suicide for a long time, the most not hungry ".
Wherein Fructus Lycii: strengthen immunity, nourishing the liver and kidney, spermatogenesis cough-relieving.Hepatic and renal YIN deficiency, soreness of the waist and knees, dizziness, forgetful, dizzy, the many tear of blurred vision, quench one's thirst, pass out semen, the disease such as diabetes.Especially can significantly and persistently reduce blood glucose, increase carbohydrate tolerance, and toxicity is less.
Wherein Black Radix Et Rhizoma Fagopyri Tatarici has great benefit for human body, containing rutin, chlorophyll, crude protein and various trace elements, so having multiple efficacies and effect for human body.Black Radix Et Rhizoma Fagopyri Tatarici has the Tartary buckwheat biological flavonoid contained in hypoglycemic effect Tartary buckwheat tea can accelerate the recovery of pancreas edge B cell, can reduce blood glucose simultaneously, improve grain tolerance, it is possible to treatment diabetes and complication thereof.Motherland's medical science Compendium of Material Medica is recorded: Radix Et Rhizoma Fagopyri Tatarici bitter in the mouth, and property is flat cold, physical strength profiting, continuous spirit, and profit knowledge has the effect of sending down the abnormal ascending QI width intestinal stomach invigorating.Current clinical medicine is observed and is shown, Radix Et Rhizoma Fagopyri Tatarici powder and goods thereof have blood sugar lowering, blood fat reducing, strengthens the effect of body immunity, the patients such as diabetes, hypertension, hyperlipidemia, coronary heart disease, apoplexy are had auxiliary therapeutic action.
Wherein Herba Potentillae Discoloris: property is put down, sweet in the mouth, micro-hardship；Interior regulating menstruation arteries and veins, benefit vim and vigour, there is obvious hypoglycemic activity.The contained main component Cortex querci dentatae in flavone compound have suppression non-enzyme glycoslysis, and suppresses aldose reductase activity by suppression protein glycation.There is the effects such as antibacterial, antidiarrheal, blood sugar lowering and antitumor, type 2 diabetes mellitus patient is had significant hypoglycemic activity.Modern pharmacological research shows, Herba Potentillae Discoloris contains the various active compositions such as Fumaric acid, gallic acid, Quercetin, protocatechuic acid, naringenin, has the effects such as antibacterial, antidiarrheal, blood sugar lowering and antitumor, type 2 diabetes mellitus patient is had significant hypoglycemic activity.Various places are all produced, raw ripe equal edible, also can hyoscine.Root contains Flavonoid substances. and Herba Potentillae Discoloris is flat, sweet-bitter flavor, nontoxic.A lot of by Herba Potentillae Discoloris treatment diabetes benefit, medicine source is enriched, and does not spends or flower stiver controls serious disease, alleviates to obtain the financial burden of this sick friends and mental pressure.
Wherein winter folium mori: have another name called Folium Mori, evening Folium Mori, old Folium Mori.The Folium Mori gathered after frost for late fall to early winter., yellow skin orange person fertile so that leaf is big is preferred.It is conventional Chinese medicine, is mainly used in anemopyretic cold, or pulmonary has hot and suffocating.Or Liver Channel has the mesh mist epiphora induced by wind etc. caused by heat.Primary efficacy: dispelling wind and heat pathogens, clearing away lung-heat and moistening for dryness, liver heat removing and eyesight improving.Cure mainly: be mainly used in anemopyretic cold, or there is hot and suffocating cough caused by dryness in pulmonary；Or the dizziness headache caused by stagnated heat of liver channel, conjunctival congestion is dim-sighted, mesh mist epiphora induced by wind etc..And have preventing and treating anemopyretic cold, lung-heat type cough, laryngopharynx swelling and pain, headache due to deficiency of blood, eye strain, habitual constipation, dysuria, rheumatic arthralgia, additionally aid blood pressure lowering, blood sugar lowering, blood fat reducing, prevention cerebral thrombosis, lose weight, the function such as health care.
Pyridine carboxylic acid is people and mammalian liver, the interior amino acid metabolites produced of kidney, and is present in a large number in the foods such as milk.Nature chromium exists with the various valence states of Cr to Cr6+, but most common with Cr, Cr2+, Cr3+, Cr6+.Cr3+ be the chromium in the trace unit * body of needed by human be Cr3+ the most entirely, it is the constituent of glucose tolerance factor, there is ILA, the cell utilization to glucose can be promoted, promote the oxidative phosphorylation of glucose, promote Glycogen synthesis, improve the stability of insulin, thus reduce blood glucose.Chromium contributes to improving psychogenic polyphagia and the melancholy sweet food caused that is inclined to absorbs excess.Within 2005, delivered according to portion, the clinical study results done by U.S.'s Cornell University's neuromedicine shows, supplementary chromium can improve the abnormal rising of food caused because of Depressive mood, the symptom of emotion can be delayed especially especially to absorb a large amount of sweet foods, patient often has the problem that body weight explodes and blood glucose rises, taking chromium supplement eight Hou continuously, patient more than sixty percent obtains good improvement effect, degree of being emotionally stable also has made marked progress, to what because of pressure, body weight will the body constitution of baffled rising, while supplementing chromium, if Fructus Momordicae charantiae extract and Radix Panacis Quinquefolii extract can be coordinated to take, in the control of diabetes and in prevention, will there is more preferably effect.Chromium is closely related with carbohydrate metabolism.Chromium is the element that insulin plays that blood sugar reducing function is required, Cr3+ by being combined formation GT or forming other organo-chromium compounds with aminoacid and work in coordination with insulin and play its physiological function with nicotinic acid, its mechanism of action mainly forms disulfide bond by GTF regulation insulin with the Insulin receptor INSR on cell membrane, promotes insulin to play maximal biological effect.Chromium may also act to the transphosphorylase in glucose metabolism and succinate dehydrogenase, increases the utilization of sugar；Promote the expression of glucose transporter (GLUT)-4mRNA, increase glucose transport.
Pyridine carboxylic acid and Cr3+ are closely integrated into chromium picolinate, can be absorbed well by human body.Therefore chromium picolinate be a kind of allowed by Ministry of Public Health, the functional component that can add in health food, chromium picolinate (CrPic) is a kind of supplementing or selective medicine for type 2 diabetes mellitus；Experimental evidence shows, CrPic has an impact in terms of by p38MAPK activation ingestion of glucose；Chromium is believed to strengthen insulin function, causes insulin sensitivity in type 2 diabetes mellitus to strengthen.It has been indisputable fact that chromium picolinate is applied to diabetes, and effect is obvious.
Chromium picolinate institute role is that the normal morphology maintaining insulin makes it pass through capillary wall and combine with Insulin receptor INSR, can improve the sensitivity of insulin comprehensively, effectively controls blood glucose and the level of blood fat.After scientists has successfully carried out the clinical research of pyridine acid chromium salt abroad, Beijing Hospital of China and United States Department of Agriculture's human nutrition research center have carried out clinical research to 180 example diabetes patients jointly.Result shows, takes pyridine acid chromium salt and coordinates hypoglycemic drug, can improve diabetic symptom, and after 4 months, Fasting Glucose, after the meal 2 hours blood glucoses and blood fat are decreased obviously.
Wherein Rich chromium yeast is with yeast as carrier, the yeast strain that chromium toleration ability strong, chromium-rich is high is obtained by screening, yeast cells is cultivated containing in chromic culture medium, improve chromium absorption rate in body, reduce its toxic and side effects, improve biological insulin effect, preferably play its regulation blood glucose, blood fat reducing and the effect of cholesterol reducing.The nutrient substance such as the rich in proteins of Rich chromium yeast own, vitamin B group, in addition to can using as chromium source, are the most also provided that other nutritional benefit elements.The application of Rich chromium yeast, the treatment diabetes being applied to diabetes not only endanger human health, and sickness rate rises year by year, the pathology of diabetes illustrates the most completely at present, and the metabolism disorder of inorganic elements is one of pathogenic factors, wherein, chromium is increasingly subject to people's attention.In diabetes patient, major part is the polymorphic type diabetes patient formed due to insulin resistant.Research finds；The diabetes patient with insulin resistant is less than normal person with blood chromium content after the meal on an empty stomach, therefore chromium supplement is to improve one of insulin utilization rate, the effective way reducing insulin resistant, can alleviate the numerous diabetic complications caused due to insulin resistant simultaneously.Use chromium supplement method treatment polytype diabetes curative effect notable clinically.Rich chromium yeast can not only be used for treating the medicine of disease, is again a kind of good nutrient and healthcare products, and Rich chromium yeast is avoided that the toxicity of inorganic chromate salt, regulation human body sugar, lipid and protein metabolism, is one biological chromium supplement safely and efficiently.Rich chromium yeast is the biological product of pure natural, safety non-toxic, and absorbance is high, uses Rich chromium yeast as the supplementary of human body, and market prospect is the most wide.
The present invention innovatively carries out ideally organic assembling the pure natural Chinese herbal medicine of 13 tastes and mineral, and the characteristic of the Chinese medicine according to this 13 taste, it is divided into three groups, further according to the performance of medicinal ingredient contained by this Chinese medicine of three groups, carry out extracting medicinal ingredient by differently method respectively, and some side effect of the long-term taking that the pure natural Chinese herbal medicine of this 13 taste compensate for chromium picolinate and Rich chromium yeast is brought, while treatment diabetes, also function to protect the liver, protect kidney, the health care such as enrich blood；The present invention not only low cost, technique are simple, have no side effect, with long-term taking, and nature blood sugar lowering, steady sugar can be reached, repair islets of langerhans, activation insulin secretion function, use the present invention can gradually withdraw Western medicine, reduce the toxic and side effects of Western medicine, effectively control the injection of insulin dosage.
According to available in clinical laboratory data, the beneficial effect of the technology of the present invention six big advantages during blood sugar lowering:
1, safety and steady blood sugar lowering, his not hype up islet β cell insulin, but by increasing muscle, the fat effective utilization to sugar, regulation blood glucose, directly activate the DNA polymerase of islet cells, quickly repair the impaired and beta Cell of islet of atrophy, correct insulin secretion pattern extremely, increase number and the affinity of beta Cell of islet.
2, complication is blocked: as vexed in fatigue and weak, numb limbs and tense tendons, skin pruritus, blurred vision, insomnia, three-many-one-little, sexual hypofunction etc., its contain come from natural plants pancreatic cell regeneration element and and insulin sensitivity enhancing element, the metabolism of lipid, protein, sugar and trace element can be regulated, the metabolism making various organ is normal, eliminates urine protein and the complication caused by hyperglycemia, hyperlipidemia.
3, the present invention suppresses liver, kidney gluconeogenesis, at regulation blood glucose simultaneously, provides energy for body, and health spirit is strong.
4, inventive formulation is excellent, and toxic and side effects is little: raw material extracts from green natural Chinese crude drug through high-tech biology, does not cause the direct secretion effect of insulin, is not result in β cell damage.
5, the present invention can make β cell regeneration, gradually recovers islet function, from radical change hypoinsulinism and insulin resistant, improves receptor sensitivity and affinity, makes insulin fully be combined with receptor, steady blood glucose.
6, the present invention can destroy glucagon secretion, thus reduces his destruction to insulin, makes islet function strengthen, plays the effect of steady blood glucose.
Detailed description of the invention
For the technological means making the present invention realize, creation characteristic, reach purpose and be easy to understand with effect, below in conjunction with detailed description of the invention, the present invention is expanded on further.
Embodiment 1
The preparation method of the Chinese prescription of this treatment diabetes of the present invention is:
Step one, choose boxthorn root 15 parts, bosom Radix Rehmanniae 12 parts, Rhizoma Polygonati Odorati 8 parts, the Radix Astragali 20 parts, Rhizoma Polygonati 9 parts, Radix Puerariae 18 parts, this seven tastes Chinese medicine of RHIIZOMA DIOSCOREAE fr0m Henan of China 23 parts, it is carried out, is placed on natural air drying in net bed, put into grinder and be ground 2-3 hour, obtaining this seven tastes Chinese medicine mixed-powder, the powder size after grinding is a size of in 0.1 μm-10 μm, 1 or the interval grain size intervals of more than 1 in 0.044mm-0.074mm, 0.074-1mm；
Step 2, choose 15 parts of Fructus Momordicae charantiae, Radix Ophiopogonis 10 parts, Fructus Lycii 10 parts, this four tastes Chinese medicine of Black Radix Et Rhizoma Fagopyri Tatarici 13 parts, it is carried out, add little molecular energy water and boil 1-2h, next mixture is cooled down, fried juice is filtered by the nylon mesh of 50 μm, filtrate carries out separating 2 times in centrifuge, then 10min collects supernatant liquid every time, it is centrifuged separating until not having precipitate to separate out collecting liquid, united extraction liquid, by extracting solution through cold drying, concentrate, obtain viscous mixture, at temperature 150 degree, it is dried, obtain solid mixture after drying, put into and carry out pulverizing 0.8 hour with pulverizer, obtain Fructus Momordicae charantiae, Radix Ophiopogonis, Fructus Lycii and Black Radix Et Rhizoma Fagopyri Tatarici concentrate hybrid particles；
Step 3, choose Herba Potentillae Discoloris 18 parts, this two tastes Chinese medicine of winter folium mori 6 parts, soak with the little molecular energy water of Herba Potentillae Discoloris and winter folium mori gross weight 1-2 times, soak 3 hours, stir 0.5 hour, carry out vibration of ultrasonic wave 25 minutes, add alimentary acetic acid, be adjusted to pH value 5, add Herba Potentillae Discoloris and winter folium mori gross weight 1% cellulase, it is sufficiently stirred for, putting into dry distillation reactor still, after heating, in still, product enters condenser along reactor upper pipe, cool down, through distillation, leach to obtain leachate；By leachate through cold drying, concentration, obtain viscous mixture, at temperature 100 degree, be dried, obtain solid mixture after drying, put into and carry out pulverizing 1 hour with pulverizer, obtain Herba Potentillae Discoloris and winter folium mori concentrates hybrid particles；
The Herba Potentillae Discoloris that Fructus Momordicae charantiae, Radix Ophiopogonis, Fructus Lycii and Black Radix Et Rhizoma Fagopyri Tatarici concentrate hybrid particles, step 3 obtains and winter folium mori that step 4, the boxthorn root that step one is obtained, bosom Radix Rehmanniae, Rhizoma Polygonati Odorati, the Radix Astragali, Rhizoma Polygonati, Radix Puerariae, the mixed-powder of this seven tastes Chinese medicine of RHIIZOMA DIOSCOREAE fr0m Henan of China, step 2 obtain concentrate hybrid particles and the chromium picolinate of 1 part, the Rich chromium yeast Rich chromium yeast mixing of 3 parts, after mix homogeneously, being packaged into capsule, each capsule fills 0.4-0.5 gram.
Embodiment 2
The preparation method of the Chinese prescription of this treatment diabetes of the present invention is:
Step one, choose boxthorn root 12 parts, bosom Radix Rehmanniae 10 parts, Rhizoma Polygonati Odorati 12 parts, the Radix Astragali 20 parts, Rhizoma Polygonati 8 parts, Radix Puerariae 16 parts, this seven tastes Chinese medicine of RHIIZOMA DIOSCOREAE fr0m Henan of China 22 parts, it is carried out, is placed on natural air drying in net bed, put into grinder and be ground 2-3 hour, obtaining this seven tastes Chinese medicine mixed-powder, the powder size after grinding is a size of in 0.1 μm-10 μm, 1 or the interval grain size intervals of more than 1 in 0.044mm-0.074mm, 0.074-1mm；
Step 2, choose 10 parts of Fructus Momordicae charantiae, Radix Ophiopogonis 12 parts, Fructus Lycii 10 parts, this four tastes Chinese medicine of Black Radix Et Rhizoma Fagopyri Tatarici 15 parts, it is carried out, add little molecular energy water and boil 1-2h, next mixture is cooled down, fried juice is filtered by the nylon mesh of 50 μm, filtrate carries out separating 2 times in centrifuge, then 10min collects supernatant liquid every time, it is centrifuged separating until not having precipitate to separate out collecting liquid, united extraction liquid, by extracting solution through cold drying, concentrate, obtain viscous mixture, at temperature 100 degree, it is dried, obtain solid mixture after drying, put into and carry out pulverizing 0.5 hour with pulverizer, obtain Fructus Momordicae charantiae, Radix Ophiopogonis, Fructus Lycii and Black Radix Et Rhizoma Fagopyri Tatarici concentrate hybrid particles；
Step 3, choose Herba Potentillae Discoloris 16 parts, this two tastes Chinese medicine of winter folium mori 5 parts, soak with the little molecular energy water of Herba Potentillae Discoloris and winter folium mori gross weight 1.5 times, soak 3 hours, stir 0.5 hour, carry out vibration of ultrasonic wave 25 minutes, add alimentary acetic acid, be adjusted to pH value 5, add Herba Potentillae Discoloris and winter folium mori gross weight 5% cellulase, it is sufficiently stirred for, putting into dry distillation reactor still, after heating, in still, product enters condenser along reactor upper pipe, cool down, through distillation, leach to obtain leachate；By leachate through cold drying, concentration, obtain viscous mixture, at temperature 150 degree, be dried, obtain solid mixture after drying, put into and carry out pulverizing 1 hour with pulverizer, obtain Herba Potentillae Discoloris and winter folium mori concentrates hybrid particles；
The Herba Potentillae Discoloris that Fructus Momordicae charantiae, Radix Ophiopogonis, Fructus Lycii and Black Radix Et Rhizoma Fagopyri Tatarici concentrate hybrid particles, step 3 obtains and winter folium mori that step 4, the boxthorn root that step one is obtained, bosom Radix Rehmanniae, Rhizoma Polygonati Odorati, the Radix Astragali, Rhizoma Polygonati, Radix Puerariae, the mixed-powder of this seven tastes Chinese medicine of RHIIZOMA DIOSCOREAE fr0m Henan of China, step 2 obtain concentrate hybrid particles and the chromium picolinate of 2 parts, the Rich chromium yeast Rich chromium yeast mixing of 4 parts, after mix homogeneously, it is packaged into pellet granule.
Embodiment 3
The preparation method of the Chinese prescription of this treatment diabetes of the present invention is:
Step one, choose boxthorn root 15 parts, bosom Radix Rehmanniae 12 parts, Rhizoma Polygonati Odorati 10 parts, the Radix Astragali 18 parts, Rhizoma Polygonati 9 parts, Radix Puerariae 18 parts, this seven tastes Chinese medicine of RHIIZOMA DIOSCOREAE fr0m Henan of China 25 parts, it is carried out, is placed on natural air drying in net bed, put into grinder and be ground 3 hours, obtaining this seven tastes Chinese medicine mixed-powder, the powder size after grinding is a size of in 0.1 μm-10 μm, 1 or the interval grain size intervals of more than 1 in 0.044mm-0.074mm, 0.074-1mm；
Step 2, choose 15 parts of Fructus Momordicae charantiae, Radix Ophiopogonis 10 parts, Fructus Lycii 10 parts, this four tastes Chinese medicine of Black Radix Et Rhizoma Fagopyri Tatarici 15 parts, it is carried out, add little molecular energy water and boil 2h, next mixture is cooled down, fried juice is filtered by the nylon mesh of 50 μm, filtrate carries out separating 3 times in centrifuge, then 10min collects supernatant liquid every time, it is centrifuged separating until not having precipitate to separate out collecting liquid, united extraction liquid, by extracting solution through cold drying, concentrate, obtain viscous mixture, at temperature 150 degree, it is dried, obtain solid mixture after drying, put into and carry out pulverizing 1 hour with pulverizer, obtain Fructus Momordicae charantiae, Radix Ophiopogonis, Fructus Lycii and Black Radix Et Rhizoma Fagopyri Tatarici concentrate hybrid particles；
Step 3, choose Herba Potentillae Discoloris 18 parts, this two tastes Chinese medicine of winter folium mori 6 parts, soaks with the little molecular energy water of Herba Potentillae Discoloris and winter folium mori gross weight 2 times, soak 4 hours, stir 1 hour, carry out vibration of ultrasonic wave 20 minutes, add alimentary acetic acid, be adjusted to pH value 5, add Herba Potentillae Discoloris and winter folium mori gross weight 10% cellulase, it is sufficiently stirred for, putting into dry distillation reactor still, after heating, in still, product enters condenser along reactor upper pipe, cool down, through distillation, leach to obtain leachate；By leachate through cold drying, concentration, obtain viscous mixture, at temperature 150 degree, be dried, obtain solid mixture after drying, put into and carry out pulverizing 2 hours with pulverizer, obtain Herba Potentillae Discoloris and winter folium mori concentrates hybrid particles；
The Herba Potentillae Discoloris that Fructus Momordicae charantiae, Radix Ophiopogonis, Fructus Lycii and Black Radix Et Rhizoma Fagopyri Tatarici concentrate hybrid particles, step 3 obtains and winter folium mori that step 4, the boxthorn root that step one is obtained, bosom Radix Rehmanniae, Rhizoma Polygonati Odorati, the Radix Astragali, Rhizoma Polygonati, Radix Puerariae, the mixed-powder of this seven tastes Chinese medicine of RHIIZOMA DIOSCOREAE fr0m Henan of China, step 2 obtain concentrate hybrid particles and the chromium picolinate of 5 parts, the Rich chromium yeast Rich chromium yeast mixing of 2 parts, after mix homogeneously, tabletting finished product, every is 0.6-0.7 gram.
The effect of Chinese medicine composition of the present invention is investigated by clinical trial, accept 180 examples type ii diabetes patient in various degree altogether for medical treatment, age 36～68 years old, it is divided into three groups, often organize 60 people, take the medicine in three embodiments respectively, adhered to taking medicine through 120 days, in conjunction with diet control health invigorating, therapeutic effect is as follows: detect through clinical experiment, and wherein the patient of 12 examples whole blood blood glucose on an empty stomach is 3.9～6.1 mM/ls, and plasma glucose is 3.9～6.9 mM/ls, basic healing, accounts for the 6.7% of clinical experiment total number of persons；Detecting through clinical experiment, wherein the patient of 136 examples 5.8-7.0 mM/l of whole blood blood glucose, plasma glucose >=6.0-7.5 mM/l on an empty stomach, blood glucose target is decreased obviously, and accounts for the 75.6% of clinical experiment total number of persons；After 32 example patients take medicine, health has clear improvement, and can disable other drug, before dizziness and blurred vision, and cardiopalmus situation of shaking occurs the most again, is interested in continuing with taking medicine, accounts for 17.8%；Above case all without obvious drug dependence, carries out inspection find no toxic and side effects to heart, liver, renal function, blood system, is also not apparent from causing the aging of insulin cell or induction complication.
The present invention brings a piece of life to all types diabetic, and the applicant is during the long-term utilization present invention, and the most people's diabetics more than 600, from being treated in various degree and rehabilitation.Existing 520 people withdraw Western medicine, wherein have 380 people to subtract, stop injection of insulin, have 80 people to take a favorable turn, be currently in use.Effective percentage accounts for 98%, and applicable crowd is mainly distributed on Beijing, Shanxi, Henan, Xinjiang and foreign market.
Claims (5)
1. the Chinese medicine product treating diabetes, it is characterised in that: include the thing of following parts by weight
Matter: boxthorn root 12-15 part, bosom Radix Rehmanniae 8-12 part, Rhizoma Polygonati Odorati 8-13 part, Radix Astragali 12-20 part,
Rhizoma Polygonati 5-9 part, Radix Puerariae 15-18 part, RHIIZOMA DIOSCOREAE fr0m Henan of China 20-25 part, Fructus Momordicae charantiae 8-15 part, Radix Ophiopogonis
10-15 part, Fructus Lycii 10-12 part, Black Radix Et Rhizoma Fagopyri Tatarici 12-15 part, Herba Potentillae Discoloris 15-18 part, winter Mulberry
Leaf 3-6 part, chromium picolinate 1-5 part, Rich chromium yeast 3-5 part.
A kind of Chinese medicine product treating diabetes the most according to claim 1, it is characterised in that: turn over
Pennisetum centrasiaticum Tzvel and boxthorn root select wild plant.
A kind of Chinese medicine product treating diabetes the most according to claim 1, it is characterised in that: total
Parts by weight are 168 parts-188 parts.
The preparation method of a kind of Chinese medicine product treating diabetes the most according to claim 1, it is special
Levy and be: step one, be chosen for boxthorn root 12-15 part, cherish Radix Rehmanniae 8-12 part, Rhizoma Polygonati Odorati 8-13
Part, Radix Astragali 12-20 part, Rhizoma Polygonati 5-9 part, Radix Puerariae 15-18 part, RHIIZOMA DIOSCOREAE fr0m Henan of China 20-25 part this
Seven taste Chinese medicines, are carried out, are placed on natural air drying in net bed, put into grinder and be ground 2-3
Hour, obtain this seven tastes Chinese medicine mixed-powder；Step 2, choose Fructus Momordicae charantiae 8-15 part, Radix Ophiopogonis
10-15 part, Fructus Lycii 10-12 part, this four tastes Chinese medicine of Black Radix Et Rhizoma Fagopyri Tatarici 12-15 part, it is carried out,
Adding little molecular energy water and boil 1-2h, next mixture is cooled down, fried juice passes through
The nylon mesh of 50 μm filters, and filtrate carries out separating 2～3 times in centrifuge, and each 10
Then min collects supernatant liquid, is centrifuged separating until not having precipitate collecting liquid
Separate out, united extraction liquid, by extracting solution through cold drying, concentration, obtain viscous mixture,
Under temperature 100-150 degree, it is dried, obtains solid mixture after drying, put into and use powder
Broken machine carries out pulverizing 0.5-1 hour, obtains Fructus Momordicae charantiae, Radix Ophiopogonis, Fructus Lycii and Black Radix Et Rhizoma Fagopyri Tatarici and concentrates mixing
Granule；Step 3, choose Herba Potentillae Discoloris 15-18 part, this two tastes Chinese medicine of winter folium mori 3-6 part, use
The little molecular energy water of Herba Potentillae Discoloris and winter folium mori gross weight 1-2 times soaks, and soaks 3-4 little
Time, stir 0.2-1 hour, carry out vibration of ultrasonic wave 20-30 minute, add alimentary acetic acid,
It is adjusted to pH value at 4-5, adds the cellulase of the 1-10% of Herba Potentillae Discoloris and winter folium mori gross weight, fill
Dividing stirring, put into dry distillation reactor still, after heating, in still, product is along reactor upper pipe
Enter condenser, cool down, through distillation, leach to obtain leachate；By leachate through low temperature
It is dried, concentrates, obtain viscous mixture, under temperature 100-150 degree, be dried, dry
Obtain solid mixture after dry, put into and carry out pulverizing 1-2 hour with pulverizer, obtain Herba Potentillae Discoloris
Hybrid particles is concentrated with winter folium mori；Step 4, the boxthorn root that step one is obtained, bosom Radix Rehmanniae,
Rhizoma Polygonati Odorati, the Radix Astragali, Rhizoma Polygonati, Radix Puerariae, the mixed-powder of this seven tastes Chinese medicine of RHIIZOMA DIOSCOREAE fr0m Henan of China, step 2 obtain
To Fructus Momordicae charantiae, Radix Ophiopogonis, Fructus Lycii and Black Radix Et Rhizoma Fagopyri Tatarici concentrate hybrid particles, step 3 obtains Herba Potentillae Discoloris
With the chromium picolinate that winter folium mori concentrates hybrid particles and 1-5 part, the Rich chromium yeast of 3-5 part is rich
Chromium yeast mixes, and after mix homogeneously, is packaged into capsule or pellet granule or tabletting finished product.
The preparation method of a kind of Chinese medicine product treating diabetes the most according to claim 4, it is special
Levy and be: the size after this seven tastes Chinese medicine mixed-powder grinds in step one is in 0.1 μm
-10 μm, 1 in 0.044mm-0.074mm, 0.074-1mm or more than 1
Grain size intervals.
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| CN106975010A (en) * | 2017-04-06 | 2017-07-25 | 李建明 | A kind of Chinese medicine composition for treating diabetes |
| CN107981330A (en) * | 2017-11-30 | 2018-05-04 | 云南露源野生真菌研究所（有限合伙） | A kind of diabetes diet therapy composition and preparation method thereof |
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| CN110623266A (en) * | 2019-10-18 | 2019-12-31 | 兰州奇正生态健康品有限公司 | Health food for assisting in reducing blood sugar and preparation method thereof |
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| CN112245536A (en) * | 2020-10-13 | 2021-01-22 | 四川碧康生物科技有限公司 | A Chinese medicinal composition for treating diabetes |
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| CN112089828A (en) * | 2019-06-16 | 2020-12-18 | 王虎 | Preparation method of biological fermentation type compound trivalent chromium hypoglycemic combination drug |
| CN110623266A (en) * | 2019-10-18 | 2019-12-31 | 兰州奇正生态健康品有限公司 | Health food for assisting in reducing blood sugar and preparation method thereof |
| CN112245536A (en) * | 2020-10-13 | 2021-01-22 | 四川碧康生物科技有限公司 | A Chinese medicinal composition for treating diabetes |
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Application publication date: 20160928 |