CN108671116A - Herbal composite and its preparation for treating diabetes and instructions of taking - Google Patents
Herbal composite and its preparation for treating diabetes and instructions of taking Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/37—Celastraceae (Staff-tree or Bittersweet family), e.g. tripterygium or spindletree
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
- A61K36/428—Trichosanthes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/488—Pueraria (kudzu)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/77—Sapindaceae (Soapberry family), e.g. lychee or soapberry
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/894—Dioscoreaceae (Yam family)
- A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Abstract
The invention discloses a kind of herbal composite for treating diabetes and its preparation and instructions of taking, belong to field of Chinese herbal.The above-mentioned herbal composite for treating diabetes is made of following parts by weight of component：1 15 parts of Ramulus euonymi；15 30 parts of Radix Astragali；10 30 parts of matrimony vine；1 10 parts of Chinese yam；10 30 parts of the root bark of Chinese wolf-berry；10 20 parts of pueraria lobata；20 40 parts of bitter buckwheat；10 30 parts of root of Chinese trichosanthes；1 10 parts of semen litchi.The present invention can effectively treat and prevent the diabetes caused by insufficient insulin and its complication by the synergistic effect between specific components, increase patient's own insulin secretion capacity, achieve the purpose that prevention and treatment are synchronous.
Description
Technical field
The present invention relates to field of Chinese herbal, are specifically to provide a kind of herbal composite and its system for treating diabetes
Standby and instructions of taking.
Background technology
Diabetes are one group of metabolic diseases characterized by hyperglycemia.Hyperglycemia be then due to defect of insulin secretion or
Its biological effect is impaired, or both have concurrently and cause.Long-standing hyperglycemia when diabetes, cause various tissues, especially eye,
Kidney, heart, blood vessel, the chronic lesion of nerve, dysfunction.Type 1 diabetes and diabetes B are broadly divided into, clinical majority is 2
Patients with type Ⅰ DM, basic pathology are sugar, protein, fat, Water-Electrolyte caused by internal insulin relative or absolute deficiency
Metabolic disorder, it is characterized in that hyperglycemia, glucose in urine, glucose tolerance and insulin release test are abnormal.Illness be more drinks,
More foods diuresis, polydipsia, are become thin, fatigue and weak etc..Due to there is no the drug of radical cure diabetes at present, the whole world is all from difference
The new therapy of way exploration.
In the prior art, has the related report for utilizing traditional Chinese medicine composition for treating diabetes：
Patent CN104306659A provides a kind of Chinese medicine composition for treating diabetes B, the selected Radix Astragali of Chinese medicine composition,
Radix pseudostellariae, the coptis, balsam pear, Radix Rehmanniae, rhizoma atractylodis, radix scrophulariae, rhizoma anemarrhenae, pueraria lobata, Radix Salviae Miltiorrhizae, Ramulus euonymi, the root bark of Chinese wolf-berry, mulberry skin, Prunella vulgaris, red crowned crane
Grass, semen litchi, potentilla discolor are made.
Patent CN103520586A discloses a kind of Chinese medicine composition for treating diabetes, by include dogwood fruit, the fruit of Chinese wolfberry,
The 46 taste bulk pharmaceutical chemicals such as mulberry fruit, prepared fleece flower root, Semen sesami nigrum, the fruit of glossy privet, prepared rehmannia root, Herba Epimedii, silky ant, Cortex Eucommiae are prepared.It should
The Chinese medicine composition of invention is started with from nourishing liver and kidney, effect a permanent cure based on, clearing heat and cooling blood, adjust human body, correct glucose -lipid metabolism disorder, change
Kind microcirculation, is directly used in pancreas islet righting the five internal organs, activates internal pancreatic cell, repairs and promotes islet function, and to complication
Rapid control is eliminated, and blood glucose is made steadily to decline, until human body yin-yang balancing, thoroughly eradicates diabetes.
In the prior art, the herbal composite types of medicines for treating diabetes is more, and cost is higher.
Invention content
The present invention provides a kind of herbal composite and its preparation and instructions of taking for treating diabetes, and the present invention is special
The herbal composite that fixed formula obtains can effectively treat and prevent diabetes caused by insufficient insulin and its concurrent
Disease increases patient's own insulin secretion capacity, achievees the purpose that prevention and treatment are synchronous.
In order to solve the above technical problems, present invention offer technical solution is as follows：
The present invention provides a kind of herbal composite for treating diabetes, is made of following parts by weight of component：
Preferably, the above-mentioned herbal composite for treating diabetes is made of following parts by weight of component：
Preferably, the above-mentioned herbal composite for treating diabetes is made of following parts by weight of component：
Wherein, Ramulus euonymi bitter, it is cold in nature.Effect：It is promoting blood circulation and removing blood stasis, clearing and activating the channels and collaterals.Its tradition, which is applied, is：The address passages through which vital energy circulates stasis of blood is stagnant
Traumatic injury, delayed period, the illnesss such as stasis of blood and rheumatism numbness is logical.This medicine is usually used in traditional prescription：1. Ramulus euonymi
It dissipates：Ramulus euonymi, peach kernel, radix paeoniae rubra, Radix Angelicae Sinensis, Podophyllum emodi var chinense, osmanthus heart, radix bupleuri, rheum officinale, cinnabar, dried orange peel treat pestilent epigastralgia；2. Radix Angelicae Sinensis is drunk：
Radix Angelicae Sinensis, Ramulus euonymi, treatment postpartum anemic fainting is wild.Mainly contained in Ramulus euonymi Oxaloacetic of winged euonymus cardiac glycosides and hypoglycemic etc. at
Point.Its pharmacological action：1. cardiac stimulant, coronary dilatation, decompression；2. hypoglycemic：Oxaloacetic sodium can promote pancreas beta cell hyperplasia, A cells to wither
Insulin secretion is reinforced in contracting, thus plays the role of reducing blood glucose.Clinically it is mainly used for treating coronary heart disease, high worry, myocarditis
Etc. heart diseases myocardial damage；Treat Gao Xuya, artery sclerosis；Treat diabetes；Treat cervical spondylosis, cerebral arterial insufficiency.Ghost
Fletching can expand peripheral vessels, there is weak antihypertensive effect, can treat hypertension.Reusable Chinese medicine while taking depressor
Ramulus euonymi, Rhizoma Gastrodiae, uncaria, RADIX POLYGONI MULTIFLORI PREPARATA etc. assist decompression, anti-angiogenic hardening and the improvement symptoms such as dizziness.Meanwhile coping with terrible arrow
The blood sugar reducing function of plumage should adequately recognize, and clinic Ramulus euonymi 30g is equal with Chinaroot Greenbier Rhizome, raw pueraria lobata and uses, to mild diabetes,
Or blood glucose maintains light, moderate increasing state after taking antidiabetic drug, adds with after these Chinese medicines, Chinese and Western medicine is used in combination, and can heighten the effect of a treatment, blood
Sugar can decline at leisure, until normal range (NR).
Radix Astragali：Slightly warm in nature sweet in flavor.Return lung, spleen, liver and kidney channel.Polishing consolidates table, torr sore myogenic.Cure mainly physically weak spontaneous perspiration, chronic diarrhea,
Rectal prolapse, the prolapse of uterus, chronic nephritis, physically weak edema, chronic ulcer, the long disunion of the open sore part.Effect：1. invigorating qi for consolidating superficies：Life is yellow
Stilbene has the effect of invigorating qi for consolidating superficies, inducing diuresis for removing edema, detoxification, myogenic, is suitable for spontaneous perspiration, night sweat, blood-arthralgia, edema, un-festering of ulcer or bursts
It does not hold back long and waits diseases.2. benefiting qi and nourishing blood：Preparing astragalus membranaceus has effect in tonifying Qi, blood-nourishing, benefit, is suitable for internal injury overstrain, splenasthenic diarrhea, gas
The diseases such as void, the deficiency of blood, laboured breathing.3. blood pressure lowering：Modern medicine proves that Radix Astragali has reduction blood viscosity, reduces thrombosis, drop
Low blood pressure, cardioprotection, bidirectional modulation blood glucose, Green Tea Extract damage, anti-aging, anti anoxia, antitumor, enhancing immunity of organisms
Effect, can be used to treat the diseases such as heart disease, hypertension, diabetes.Radix Astragali can also expand blood vessel, improve skin blood cycle and battalion
The situation of supporting, thus it is effective to the long disunion person of chronic ulcer.It can also eliminate the albuminuria of nephritis patient, protect liver, prevent liver
Glycogen is reduced.4. inducing diuresis for removing edema：The main transmitting and distributing the fluids of spleen, Spleen-Qi Deficiency, then transporting is ineffective, Radix Astragali can invigorate the spleen and benefit qi effect a permanent cure and
Energy inducing diuresis to remove edema is taken stopgap measures, and is one of the important drugs for treating qi and blood oedema.5. shengjin nourishing：Radix Astragali itself has the work(of blood-nourishing
Effect, and green blood is contributed to by the effect of tonifying Qi again, therefore Radix Astragali is also commonly used for treating blood deficiency chlorosis and syndrome of deficiency of both qi and blood.
6. antitumor：Active ingredient astragalus polyose has shared the work(of Synergy and attenuation with antitumor drug in Radix Astragali, that is, enhances anticancer effect,
Mitigate side effect.
Matrimony vine：Containing nutritional ingredients such as glycine betaine, amino acid, carrotene, vitamin B1, B2, C, calcium, phosphorus, iron,《God
Agriculture book on Chinese herbal medicine passes through》In be listed in top grade, there are many health-care efficacy.Effect has：1. immunoregulation effect：There is enhancing nospecific immunity
Effect improves disease resistance, inhibits tumour growth and cell mutation.2. anti-aging effects：Human trial, which is shown, obviously to be inhibited
Serum LPo is generated, and GSH-Px vigor in blood is made to increase, but erythrocyte sod vigor has no raising, and embodiment fructus lycii extracted solution, which has, to be prolonged
Slow aging effect.3. antitumor action：Matrimony vine is to the generation of cancer cell and is diffused with apparent inhibiting effect, present age experiment and faces
Bed application the result shows that, wolfberry leaf is often drunk for tea, can significant raising and improvement old man, valetudinarian and tumour patient exempt from
Epidemic disease function and physiological function have the function of strong human body and anti-aging.4. antifatigue effect：Polysaccharides can significantly improve
Muscle glycogen, liver glycogen reserves amount improve the front and back blood lactic acid dehydrogenase total activity of movement.⑤：Hypoglycemic effect：Wolfberry fruit extract
Blood glucose can significantly and be persistently reduced, increases sugar tolerance, and toxicity is smaller.6. improving eyesight effect：Contained abundant B mono- in matrimony vine
Carrotene can be converted to vitamin A in human body, and the producible retinol of vitamin A prevents maculopathy to improve eyesight.
7. protecting liver effect：Polysaccharides has repair to hepatic injury, by preventing the damage of endoplasmic reticulum, promotes protein synthesis
And detoxication, restore the function of liver cell, and promote the regeneration of liver cell.8. enhancing hematopoiesis function effect：Matrimony vine has obviously
The effect for promoting hematopoietic cell proliferation, can be such that leukocyte count increases, enhance the hematopoiesis function of human body.
Chinese yam：It is sweet in flavor, mild-natured, enter lung, spleen, kidney channel；It is not dry oiliness.With strengthening the spleen and tonifying the lung, beneficial stomach kidney tonifying, reinforce the kidney beneficial essence,
Hearing-improing and eyesight improving helps the five internal organs, strengthening the bones and muscles, long will to calm the nerves, the effect of promoting longevity.Cure mainly weakness of the spleen and the stomach, lassitude, appetite not
It shakes, chronic diarrhea and dysentery, Lung Qi deficiency is dry, phlegm asthma cough, kidney qi loss, soreness and weakness of waist and knees, lower limb impotence is weak, frequent micturition of quenching one's thirst, premature ejaculation of passing out semen, band
The illnesss such as the red swollen, obesity of lower gonorrhoea, skin.
The root bark of Chinese wolf-berry：Root bark of Chinese wolf-berry nature and flavor are cold in nature, sweet in flavor.Major function cool blood is except steaming, clearing lung-heat fall fire.For deficiency of Yin hectic fever, bone
Steam night sweat, cough with lung heat, spitting of blood, bleeding from five sense organs or subcutaneous tissue.Effect：1. making antihypertensive effect to cardiovascular system；2. hypoglycemic effect；3. antipyretic
Effect.It is not recommended that when health products are taken, cold and cool constitution obtains that people's inedibility root bark of Chinese wolf-berry is to boil water to be drunk, and has to hyperglycemia and obviously stabilizes
Effect, and hypoglycemia will not occur.It is hypoglycemic good medicine, but is only applicable to control hyperglycemia, without should be it as extensive
The important means of multiple diabetes.
Pueraria lobata：It is sweet in flavor, pungent, mild-natured, returns spleen, stomach, lung, bladder warp.Expelling pathogenic factors from muscles and skin is brought down a fever；It delivers and examines；It promotes the production of body fluid to quench thirst；Rising Yang stops
It rushes down.Main fever caused by exogenous pathogens；Rigidity of nape and headache；Measles from the beginning of；Rash goes out unsmooth；Warm disease is thirsty；Diabete；Diarrhea；Dysentery；Hypertension；Hat
Worry.Effect：1. expanding blood vessel：Pueraria lobata, general flavone and Puerarin can improve the oxygen metabolism of cardiac muscle, be generated to myocardial metabolism beneficial
Effect, while blood vessel can be expanded, improve microcirculation, reduces vascular resistence, blood flow is made to increase, therefore prevention myocardial ischemia can be used,
Myocardial infarction, arrhythmia cordis, hypertension, the illnesss such as artery sclerosis.2. expelling pathogenic factors from muscles and skin is delivered：Pueraria lobata acetone extract has and makes temperature recovery
Normal effect, it is effective to a variety of fevers.Therefore it is thirsty to be usually used in generating heat, the illnesss such as vexed uneasiness.3. hypoglycemic：Pueraria lobata is known as
The effect of blood glucose is significantly reduced, the flavone compound contained by pueraria lobata has effect for reducing blood fat, can reduce serum cholesterol, reduces
Oily three esters, for treating hyperglycemia, hyperlipidemic conditions have significant curative effect.4. nootropic effect：It is certain research shows that pueraria lobata to study
Memory disorders have the therapeutic effect of bright journey, and pueraria lobata alcohol extracting thing, which can significantly fight the note caused by eastern degree police alkali and show, to be hindered.It can be used for controlling
Treat senile dementia, dysnoesia, the illnesss such as poor memory.5. antidiarrheal of quenching the thirst：Pueraria lobata, which gently rises clearly, to be dissipated, and pharmacological property rises hair, Liu Juyang
Gas, inspiring body, A healthy wind prevails, body fluid cloth row.It rises hair taste air positive clearly and quenches the thirst, antidiarrheal dysentery.Therefore it is usually used in treating interior heat and disappears
Yearningly, measles without adequate eruption, the illnesss such as diarrhea, dysentery.6. lipoid and reducing blood pressure of dispelling：Pueraria lobata can make blood pressure more easy to control, and capillary is made to expand
, blood viscosity reduces, and microcirculation improves.It can soften and protect blood vessel, play the role of reducing blood fat and cholesterol in human body.7. solving
Wine：Pueraria lobata can solve alcohol toxicity, and energy solution is drained rapidly after drinking.Brain of having a headache after can relieving the effect of alcohol rises, and the symptoms such as blushes.Alleviate alcohol to exist
It is absorbed in stomach, protects gastric mucosa.
Bitter buckwheat：Bitter buckwheat bitter, cold, the real stomach of energy, benefiting energy continues spirit, and it is dirty to refine the five internal organs slag for sharp knowledge.Effect：①
Has the function of anti-oxidant, increase human immunity.2. tartary buckwheat tea can effective antihypertensive, hyperlipidemia, hyperglycemia.3. can be with
Internal rubbish are removed, improves heart and brain cycle, dispelling fatigue, restore energy.4. contain a large amount of coarse food grain dietary fiber in tartary buckwheat tea,
It often drinks and can increase skin anti-oxidation function, allow skin health gloss, beautifying face and moistering lotion.5. bitter buckwheat flavone contained in bitter buckwheat, can
With effectively preventing diabetes.6. the distribution of stomach nutrition can be balanced in bitter buckwheat containing rare coarse food grain dietary fiber,
Constipation can effectively be treated.
Root of Chinese trichosanthes：It is cool in nature；Picric acid sweet in flavor；It attaches to the lung and stomach meridians.Root of Chinese trichosanthes mainly contain trichosanthin and enzyme inhibitor class etc. at
Point.Effect：1. clearing heat and promoting fluid：Cure mainly lung stomach Nei Rejin wounds.Pyreticosis injury thirst or Heat Diabetes.2. root of Chinese trichosanthes extracting solution is to just
The blood glucose of normal, hungry, diabetes 3 kinds of rabbits is all in castering action, and the hepatic glycogen of hungry rabbit can be increased, muscle glycogen contains
Amount.But the 5 kinds of chitosan components isolated from root of Chinese trichosanthes can be such that mouse blood sugar declines.3. clearing heat and promoting fluid, detumescence and apocenosis are used for pyreticosis
Polydipsia, lung-heat type cough, Heat Diabetes, sore swollen toxin.4. detumescence and apocenosis：It can be used for sore and toxic and lung carbuncle cough vomiting of pus and blood.6. it
Pollen protein plays the role of stronger inhibition duplication and sprawling to the intracellular human immunodeficiency virus of AIDS patient, and drops
Low infection cell and ratio without infection cell.7. trichosanthin has Robust speaker feature effect, embryo necrosis, liquefaction can be made, eventually extremely
It fully absorbs.
Semen litchi：Middle benefit gas, qi-regulating, analgesic.Control epigastric pain, hernia pain, women's pricking caused by the stagnation of QI and blood.Effect：1. regulating qi-flowing for relieving pain.②
Warming spleen and stomach for dispelling cold.3. semen litchi can adjust metabolism disorder of blood lipid with reducing blood lipid.4. semen litchi can be used for colic, the swollen pain of testis, stomach
Gastral cavity pain, abdomen pain.
Preferably, the bitter buckwheat dosage is the sum of the Ramulus euonymi and root of Chinese trichosanthes dosage.
The present invention also provides a kind of above-mentioned preparation methods for treating the herbal composite of diabetes, to claim in proportion
Take Ramulus euonymi, Radix Astragali, matrimony vine, Chinese yam, the root bark of Chinese wolf-berry, pueraria lobata, bitter buckwheat, root of Chinese trichosanthes, semen litchi, by above-mentioned each material mixing it is uniform after
It crushes, is prepared into clinically common formulations.
Further, the dosage form be tablet, powder capsule or pill, prepare piece agent, powder capsule or pill side
Method is common method, is no longer repeated one by one again.
The present invention also provides a kind of above-mentioned instructions of taking for treating the herbal composite of diabetes, to be stood in after meal
It takes, 3 times a day, each 3-6g, warm water takes.
Compared with prior art, the invention has the advantages that：
The present invention provides a kind of herbal composite and its preparation and instructions of taking for treating diabetes, thunder of the present invention
The herbal composite for treating diabetes fragrant reasonable, that the dosage by further adjusting specific components obtains, Neng Gouyou
Effect treats and prevents the diabetes caused by insufficient insulin and its complication, increases patient's own insulin secretion capacity, reaches
The purpose synchronous to prevention and treatment.
Specific implementation mode
To keep the technical problem to be solved in the present invention, technical solution and advantage clearer, specific embodiment will be used below
It is described in detail, but the present invention is limited to absolutely not these examples.It is as described below to be only the preferred embodiment of the present invention, it is only used to
Explain the present invention, it cannot be construed as a limitation to the scope of the present invention.It should be pointed out that all the present invention's
The all any modification, equivalent and improvement etc. done within spirit and principle, should all be included in the protection scope of the present invention.
Therefore, the protection domain of patent of the present invention should be determined by the appended claims.
Except specified otherwise, component is commercial product used in the present invention.
The present invention provides a kind of herbal composite and its preparation and instructions of taking for treating diabetes, can be effective
The diabetes caused by insufficient insulin and its complication are treated and prevented, increases patient's own insulin secretion capacity, reaches
Prevent and treat synchronous purpose.
Embodiment 1
A kind of herbal composite for treating diabetes is made of following parts by weight of component：
Embodiment 2
A kind of herbal composite for treating diabetes is made of following parts by weight of component：
Embodiment 3
A kind of herbal composite for treating diabetes is made of following parts by weight of component：
Embodiment 4
A kind of herbal composite for treating diabetes is made of following parts by weight of component：
Embodiment 5
A kind of herbal composite for treating diabetes is made of following parts by weight of component：
Embodiment 6
A kind of herbal composite for treating diabetes is made of following parts by weight of component：
Embodiment 7
A kind of herbal composite for treating diabetes is made of following parts by weight of component：
The present invention also provides a kind of above-mentioned preparation methods for treating the herbal composite of diabetes, to claim in proportion
Take Ramulus euonymi, Radix Astragali, matrimony vine, Chinese yam, the root bark of Chinese wolf-berry, pueraria lobata, bitter buckwheat, root of Chinese trichosanthes, semen litchi, by above-mentioned each material mixing it is uniform after
It crushes, is prepared into clinically common formulations.
Further, the dosage form be tablet, powder capsule or pill, prepare piece agent, powder capsule or pill side
Method is common method, is no longer repeated one by one again.
The present invention also provides a kind of above-mentioned instructions of taking for treating the herbal composite of diabetes, to be stood in after meal
It takes, 3 times a day, each 3-6g, warm water takes.
Because length is limited, further to prove the effect of the herbal composite for treating diabetes of the invention prepared
It is as follows to build comparative example only by taking embodiment 5 as an example for fruit.
Comparative example 1
A kind of herbal composite is made of following parts by weight of component：
Comparative example 2
A kind of herbal composite is made of following parts by weight of component：
Comparative example 3
A kind of herbal composite is made of following parts by weight of component：
Comparative example 4
A kind of herbal composite is made of following parts by weight of component：
Comparative example 5
A kind of herbal composite is made of following parts by weight of component：
Comparative example 6
A kind of herbal composite is made of following parts by weight of component：
Prepared by above-mentioned comparative example 1-6 and instructions of taking is same as Example 5.
Lanqin oral solutions：
1, diabetes diagnostic criterion
Diabetic symptom+random time plasma glucose levels >=11.1mmol/l (200mg/dl), or
Fasting plasma glucose (FPG) level >=7.0mmol/l (126mg/dl), or
In OGTT experiments, 2 hours PG levels >=11.1mmol/l (200mg/dl).
2, curative effect determinate standard：
It cures：1. fasting blood glucose level is less than 6.1mmol/l；2. OGTT, which tests 2 hours PG levels, is less than 11.1mmol/l；
3. random time blood glucose level is normal, and diabetic symptom and complication disappear；4. the above performance is stablized 3 days or more；
It improves：1. fasting blood glucose level is decreased obviously；2. OGTT tests 2 hours PG levels and is decreased obviously；3. diabetes
Shape or complication mitigate；
In vain：The not up to above standard.
3, hypoglycemic experiment：
Choose clean grade mouse 400, weight 180-220g takes 10 to be set as normal group after balance is fed 3 days, into
Row routine feeding, remaining mouse carry out tail vein injections alloxan；After 3 days, measurement fasting blood-glucose (FBG), FBG values >=
11.1mmol/l is Glycemia Decline success, screens the successful mouse 150 of Glycemia Decline,.15 groups are randomly divided into, if experiment
Group, blank control group, prior art group.Wherein experimental group is specific：Chinese herbal medicine combination prepared by embodiment 1-7 and comparative example 1-6
Object, according to 0.2g/kg weight volume gastric infusions；Blank control group is：Gavage the physiological saline of equivalent；Prior art group is：
Take metformin hydrochloride tablet, 0.2g/kg.Continuously feed 30 days, measure administration the 0th day, the 10th day, the 20th day, it is the 30th day small
The weight and FBG contents of mouse, weight statistics are shown in Table 1, FGB assays and the results are shown in Table 2.
Table 1
As shown in Table 1, normally group mouse weight increases, remaining group mouse weight is decreased obviously；It is administered the 10th day, blank pair
It is little according to group, prior art group and experimental mice bodyweight difference；Until administration the 20th day, mouse weight difference was opened between each group
Begin to occur；It is administered the 30th day, the mouse weight of the herbal composite of prior art group and 1-7 preparations of the embodiment of the present invention is more
Stablize；And blank control group, mouse weight significantly decline；Herbal composite prepared by comparative example 1-6 of the present invention is applied to
Diabetes mice effect is not so good as the effect of 1-6 of the embodiment of the present invention.
Compared with embodiment 5 by comparative example 1-6 it is found that lack in Traditional Chinese medicine composition formula of the present invention bitter buckwheat (comparative example 1),
Lack root of Chinese trichosanthes (comparative example 2), lack Ramulus euonymi (comparative example 3), be to reduce bitter buckwheat and root of Chinese trichosanthes (comparative example 5) simultaneously either
Kind herbal-composition prepared by the root bark of Chinese wolf-berry and semen litchi (comparative example 6), compared with the embodiment of the present invention 5, Mice Body are reduced simultaneously
It reduces again more apparent；Change simultaneously root of Chinese trichosanthes dosage so that bitter buckwheat dosage is more than the (comparison of the sum of Ramulus euonymi and root of Chinese trichosanthes dosage
Example 5), the Chinese medicine composition of preparation is applied to mouse, and effect is poorer than embodiment 5.
Table 2
As seen from the above table, normally group mouse FBG contents are relatively stable, remaining group mouse FBG is obviously increased；It is administered the 30th
It, the mouse FBG reductions of the herbal composite of prior art group and 1-7 preparations of the embodiment of the present invention are more apparent；The present invention
Herbal composite prepared by comparative example 1-6 is applied to the effect that diabetes mice effect is not so good as 1-6 of the embodiment of the present invention.
Compared with embodiment 5 by comparative example 1-6 it is found that lack in Traditional Chinese medicine composition formula of the present invention bitter buckwheat (comparative example 1),
Lack root of Chinese trichosanthes (comparative example 2), lack Ramulus euonymi (comparative example 3), be to reduce bitter buckwheat and root of Chinese trichosanthes (comparative example 5) simultaneously either
Kind herbal-composition prepared by the root bark of Chinese wolf-berry and semen litchi (comparative example 6), compared with the embodiment of the present invention 5, mouse FBG are reduced simultaneously
It is higher；Change simultaneously root of Chinese trichosanthes dosage so that bitter buckwheat dosage is more than the sum of Ramulus euonymi and root of Chinese trichosanthes dosage (comparative example 5), prepares
Chinese medicine composition be applied to mouse, effect is poorer than embodiment 5.
By Tables 1 and 2 it is found that inventive formulation is complete, wherein bitter buckwheat, root of Chinese trichosanthes and Ramulus euonymi act synergistically, and lack and appoint
One component will cause effect to be deteriorated, and there is also synergistic effects for semen litchi and the root bark of Chinese wolf-berry.Preferably, when bitter buckwheat dosage is Ramulus euonymi
When with the sum of root of Chinese trichosanthes dosage, the herbal composite effect of preparation is best.
4, clinical trial：
In recent years, it accepts diabetic 356 for medical treatment, screens to obtain 280, be randomly divided into 14 groups, one of which takes diformazan
Biguanide drug carries out conventional therapy.Remaining 13 groups are taken Chinese herbal medicine group prepared by 1-7 of the embodiment of the present invention and comparative example 1-6 respectively
Object is closed, with taking immediately after the meal, three times a day, each 3-6g.30 days as one therapeutic course observes diabetic's feelings after one course for the treatment of
Condition, statistics is cured, improvement and invalid quantity are shown in Table 3.
Table 3
As shown in Table 3, after a course for the treatment of, herbal composite prepared by 1-7 of the embodiment of the present invention is applied to clinic, patient
For effective percentage 90% or more, the effect for treating diabetic is more apparent.
To sum up, the present invention can effectively be treated and prevented because of insufficient insulin by the synergistic effect between specific components
Caused diabetes and its complication increase patient's own insulin secretion capacity, achieve the purpose that prevention and treatment are synchronous.
The above is the preferred embodiment of the present invention, it is noted that for those skilled in the art
For, without departing from the principles of the present invention, it can also make several improvements and retouch, these improvements and modifications
It should be regarded as protection scope of the present invention.
Claims (7)
1. a kind of herbal composite for treating diabetes, which is characterized in that be made of following parts by weight of component：
2. the herbal composite according to claim 1 for treating diabetes, which is characterized in that by following parts by weight
Group is grouped as：
3. the herbal composite according to claim 2 for treating diabetes, which is characterized in that by following parts by weight
Group is grouped as：
4. according to any herbal composites for treating diabetes of claim 1-3, which is characterized in that the hardship
Buckwheat dosage is the sum of the Ramulus euonymi and root of Chinese trichosanthes dosage.
5. the preparation method of any herbal composites for treating diabetes of claim 1-4, which is characterized in that
Ramulus euonymi, Radix Astragali, matrimony vine, Chinese yam, the root bark of Chinese wolf-berry, pueraria lobata, bitter buckwheat, root of Chinese trichosanthes, semen litchi are weighed in proportion, and above-mentioned each substance is mixed
It is crushed after closing uniformly, is prepared into clinically common formulations.
6. the preparation method according to claim 5 for treating the herbal composite of diabetes, which is characterized in that institute
It is tablet, powder capsule or pill to state dosage form.
7. the instructions of taking of any herbal composites for treating diabetes of claim 1-4, which is characterized in that
It is taken in immediately after meals, 3 times a day, each 3-6g.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN114081910A (en) * | 2020-08-25 | 2022-02-25 | 上海市第七人民医院 | Composition for treating diabetic nephropathy, preparation method and application |
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Application publication date: 20181019 |