CN115040612A - Composition for regulating hypertension and preparation method thereof - Google Patents

Composition for regulating hypertension and preparation method thereof Download PDF

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Publication number
CN115040612A
CN115040612A CN202210809435.5A CN202210809435A CN115040612A CN 115040612 A CN115040612 A CN 115040612A CN 202210809435 A CN202210809435 A CN 202210809435A CN 115040612 A CN115040612 A CN 115040612A
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parts
composition
blood
cordyceps militaris
ginseng
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陈淼娟
胡金兰
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/25Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258Panax (ginseng)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06Fungi, e.g. yeasts
    • A61K36/062Ascomycota
    • A61K36/066Clavicipitaceae
    • A61K36/068Cordyceps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/287Chrysanthemum, e.g. daisy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/42Cucurbitaceae (Cucumber family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/482Cassia, e.g. golden shower tree
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/488Pueraria (kudzu)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/72Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
    • A61K36/725Ziziphus, e.g. jujube
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/74Rubiaceae (Madder family)
    • A61K36/744Gardenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/81Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A61K36/815Lycium (desert-thorn)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/894Dioscoreaceae (Yam family)
    • A61K36/8945Dioscorea, e.g. yam, Chinese yam or water yam
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/896Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8969Polygonatum (Solomon's seal)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/899Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

The invention discloses a composition for conditioning hypertension and a preparation method thereof, and particularly relates to the field of medicines. The composition comprises ginseng, medlar, kudzu root, Chinese date, sealwort, white gourd, corn stigma, cassia seed, Chinese yam, gardenia, chrysanthemum and cordyceps militaris. The invention skillfully utilizes the effects of activating blood and dissolving stasis of various components in the formula, can effectively clear and dredge blood vessels, change microcirculation, recover the elasticity of blood vessels, clear harmful substances accumulated in the blood vessels for a long time, improve blood supply of heart and brain and blood supply of blood vessels and condition blood pressure, eliminate microcirculation disturbance and fully improve the blood vessel environment of a human body, and the ingredients are added with vital energy-strengthening and constitution-consolidating and liver and kidney-tonifying vitality-invigorating medicines such as cordyceps militaris, ginseng, Chinese yam and the like, so that the body function and the immunity and disease resistance can be comprehensively improved, and the convenience characteristics of the electuary are fully utilized, and the electuary is convenient to take and drink.

Description

Composition for regulating hypertension and preparation method thereof
Technical Field
The invention relates to the field of medicines, and in particular relates to a composition for conditioning hypertension and a preparation method thereof.
Background
Hypertension is a clinical syndrome characterized by an increase in systemic arterial blood pressure, which may be accompanied by functional or organic lesions in organs such as heart, brain, and kidney. Hypertension is the most common chronic disease and also the most major risk factor for cardiovascular and cerebrovascular diseases. The blood pressure of a normal person fluctuates within a certain range along with the changes of internal and external environments. In the whole population, the blood pressure level gradually increases with age, the systolic pressure is more obvious, but the diastolic pressure shows a descending trend after the age of 50, and the pulse pressure is increased. In recent years, the understanding of the effects of multiple risk factors of cardiovascular diseases and the protection of target organs of heart, brain and kidney is deepened, and the diagnosis standard of hypertension is continuously adjusted.
People also pay more and more attention to the treatment of hypertension at present, western medicines are often applied in the treatment of hypertension, however, the history of traditional Chinese medicines in China is long, the traditional Chinese medicines are continued from ancient times to present to treat pains, and the traditional Chinese medicines also have good effects, however, when the traditional Chinese medicines are used for conditioning hypertension at present, pharmacists weigh and mix the medicinal materials together, and then boil and boil the medicinal materials uniformly, so that the traditional Chinese medicines are convenient and labor-saving, but some medicinal materials cannot be separated out, even some medicinal materials are boiled for too long to cause the dissipation of the medicinal effect, and the best effect of each medicinal material cannot be achieved, and the effect of the traditional Chinese medicines for conditioning hypertension is not obvious enough, or the traditional Chinese medicines are taken for a long time and have great side effects.
Disclosure of Invention
Therefore, the invention provides a composition for conditioning hypertension and a preparation method thereof, and aims to solve the problems of poor blood pressure reducing effect, large side effect after long-term administration and the like of the existing western medicines.
In order to achieve the above purpose, the invention provides the following technical scheme:
according to one aspect of the invention, a composition for regulating hypertension is provided, which comprises ginseng, medlar, kudzu root, Chinese date, polygonatum rhizome, white gourd, corn stigma, cassia seed, Chinese yam, gardenia, chrysanthemum and cordyceps militaris.
Furthermore, the raw material medicaments of the composition comprise the following components in parts by weight: 10-30 parts of ginseng, 30-60 parts of medlar, 4-7 parts of kudzu root, 2-5 parts of Chinese date, 1-5 parts of rhizoma polygonati, 6-8 parts of white gourd, 3-5 parts of corn stigma, 6-9 parts of cassia seed, 1-9 parts of Chinese yam, 1-3 parts of cape jasmine, 7-9 parts of chrysanthemum and 3-6 parts of cordyceps militaris.
Furthermore, the raw material medicaments of the composition comprise the following components in parts by weight: 20 parts of ginseng, 40 parts of medlar, 4 parts of kudzu root, 3 parts of Chinese date, 3 parts of rhizoma polygonati, 6 parts of white gourd, 5 parts of corn stigma, 6 parts of cassia seed, 5 parts of Chinese yam, 2 parts of cape jasmine, 7 parts of chrysanthemum and 6 parts of cordyceps militaris.
Further, the raw material medicaments of the composition comprise the following components in parts by weight: 10 parts of ginseng, 60 parts of medlar, 7 parts of kudzu root, 5 parts of Chinese date, 1 part of rhizoma polygonati, 8 parts of white gourd, 3 parts of corn stigma, 9 parts of cassia seed, 9 parts of Chinese yam, 1 part of gardenia, 7 parts of chrysanthemum and 6 parts of cordyceps militaris.
Furthermore, the raw material medicaments of the composition comprise the following components in parts by weight: 30 parts of ginseng, 30 parts of medlar, 5 parts of kudzu root, 2 parts of Chinese date, 5 parts of rhizoma polygonati, 7 parts of white gourd, 4 parts of corn stigma, 7 parts of cassia seed, 1 part of Chinese yam, 3 parts of gardenia, 9 parts of chrysanthemum and 3 parts of cordyceps militaris.
According to another aspect of the present invention, there is provided a method of preparing a composition for regulating hypertension as described above, comprising:
step one, raw material treatment
Cleaning and airing the raw materials, removing damaged and deteriorated parts, removing kernels from fruit raw materials, weighing the various medicinal materials according to the mass part requirement, and drying to obtain raw medicinal materials;
step two, grinding the powder
Uniformly mixing the raw material medicines, grinding the mixture into powder, sieving the powder, and drying the powder again;
step three, packaging
Sterilizing the powder, and packaging.
Further, in the first step, the drying moisture is less than 5%.
Furthermore, in the third step, the specification of the packaged product is 0.6 g/bag.
The functions of the raw materials are as follows:
ginseng: is suitable for regulating blood pressure, recovering heart function, neurasthenia and asthenia, and has expectorant, stomach invigorating, diuretic, and exciting effects; ginseng radix has effects of improving heart contractility and frequency, exciting heart, accelerating blood flow, promoting metabolism, regulating organism nutrition status, relieving physical decline, and enhancing resistance. Ginsenoside can activate phospholipid protease and promote phospholipid biosynthesis, thereby preventing atherosclerosis of coronary artery and heart aorta. Ginseng radix has certain curative effect on various heart diseases (coronary heart disease, angina pectoris, myocardial malnutrition, etc.) and anemia.
Medlar: contains beta-carotene, xanthophyll, etc., and has effects of improving immunity, preventing tumor formation and atherosclerosis. The Chinese medicine considers that the medlar has sweet taste and mild nature, enters liver and kidney channels, and has the effects of tonifying qi and strengthening essence, nourishing liver and kidney, resisting aging, quenching thirst and warming body; has effects in enhancing nonspecific immunity.
White gourd: sweet taste and cold nature, and has the effects of clearing away heat, inducing diuresis and relieving swelling. The white gourd has low sodium content, and has good adjuvant treatment effect on arteriosclerosis, ascites due to cirrhosis, coronary heart disease, hypertension, nephritis, edema, and distention. The tartronic acid contained in the white gourd can effectively inhibit the conversion of saccharides into fat, and the white gourd does not contain fat and has low calorie, thereby having important significance for preventing the human body from being fat and helping the body building. The seeds and peel of wax gourd can also be used as medicine, and pulp and flesh of wax gourd have the effects of promoting urination, clearing heat, reducing phlegm, quenching thirst and the like. It can also be used for treating edema, phlegm asthma, summer heat, and hemorrhoid. The white gourd like the decoction with peel can achieve the effects of relieving swelling, promoting urination, clearing away summer-heat.
Cassia seed: bitter, sweet, salty and slightly cold in nature, entering liver, kidney and large intestine meridians; loosening bowel to relieve constipation, reducing blood lipid, improving eyesight, and treating constipation, hyperlipemia, and hypertension. Clearing liver-fire, improving eyesight, promoting diuresis, relaxing bowels, lowering blood pressure, and reducing blood lipid.
Kudzu root: the traditional Chinese medicine considers that the kudzuvine root has the effects of invigorating yang and relieving muscles, promoting eruption and stopping diarrhea, and relieving restlessness and quenching thirst, and can be used for treating typhoid fever, warm headache and stiff neck, dysphoria and thirst, diarrhea, dysentery, ecchymosis, hypertension, angina, deafness and the like. Modern medical research finds that the total flavone and puerarin in the root of kudzu vine have obvious effect of dilating coronary blood vessels, so that coronary blood flow is increased, and vascular resistance is reduced; the puerarin extract has obvious effect of resisting arrhythmia, and puerarin can obviously reduce the range of myocardial infarction; the pueraria flavonid and puerarin can reduce the total peripheral resistance of the heart, reduce the oxygen consumption of the myocardium, improve the working efficiency of the myocardium and improve the metabolism of infarcted myocardium; the total puerarin and puerarin in radix Puerariae can significantly reduce the activity of renin and angiotensin in blood plasma, and reduce blood pressure. Puerarin has obvious improvement effect on microcirculation disturbance, and is mainly characterized by increasing the amplitude of microvascular motion and improving local microvessel flow; the pueraria flavonid has the function of obviously expanding cerebral vessels and improving cerebral microcirculation and peripheral circulation; puerarin also can improve the blocking state of retinal vascular peripheral unit, thereby improving the visual function of diabetic patients. In addition, puerarin can also obviously inhibit the release of 5-HT in blood platelets induced by thrombin, and has the function of resisting thrombosis. The radix Puerariae total flavone and alcohol extract can improve cerebral cortex and hippocampal acetylcholine content of rat, and reduce activity of hippocampal acetylcholine transferase.
Chrysanthemum: it can disperse wind-heat, suppress liver yang, clear liver and improve vision, and can be used for treating wind-heat type common cold or warm disease, fever, slight aversion to wind-cold, headache, liver yang hyperactivity, headache vertigo, conjunctival congestion and swelling pain due to wind-heat attack or liver fire flaming upward, and dim eyesight due to deficiency of liver and kidney essence and blood. However, sang Ye has stronger action of dispelling wind-heat, clearing lung-heat and moistening dryness, cooling blood and stopping bleeding. Chrysanthemum has strong actions of pacifying liver, clearing liver and improving vision, and clearing heat and removing toxicity.
Chinese yam: sweet, warm, mild and nontoxic. Mainly treats the diseases of impairment, deficiency, shortness of breath, cold and heat, evil qi removal, middle warmer tonifying, qi and strength benefiting, muscle growth and yin strengthening. It can be taken for a long time, and has effects of improving hearing and eyesight, reducing weight, and prolonging life. This meridian. Mainly treating head and face wandering wind, head wind and eye glare, descending qi, stopping lumbago, treating asthenia, marasmus, filling five internal organs, and removing dysphoria. And (6) recording. Tonify the five consumptive diseases and seven injuries, remove cold wind, calm the heart, tranquilize mind, tonify heart qi deficiency and open up the heart hole for recording many events. And (6) screening. Strengthen tendons and bones, induce emission and induce amnesia. Daming. Replenishing kidney qi, strengthening spleen and stomach, stopping diarrhea, resolving phlegm and moistening skin and hair. Shizhen. The swelling and toxicity of raw pounded plaster can be dissipated. The process is Shaheng.
Corn silk: sweet and light taste, mild nature, and is beneficial to urination and detumescence; clearing liver-fire, promoting bile flow, and treating edema, dribbling urine, jaundice, cholecystitis, cholelithiasis, hypertension, diabetes, and galactostasis.
Rhizoma polygonati: sweet taste, mild nature, qi invigorating, yin nourishing, spleen invigorating, lung moistening, kidney invigorating, and can be used for treating deficiency of spleen qi and stomach qi, tiredness, debilitation, stomach yin deficiency, dry mouth, anorexia, lung deficiency, dry cough, hemoptysis, essence and blood deficiency, soreness of waist and knees, early white beard and hair, internal heat, diabetes, and can help medicine vigor and make it not greasy. .
Gardenia: bitter and cold, purging fire and relieving restlessness, clearing heat and promoting diuresis, cooling blood and removing toxicity; it has repercussive and analgesic effects, and can be used for treating vexation due to febrile disease, jaundice due to damp-heat, stranguria, hematemesis, epistaxis, conjunctival congestion, swelling and pain, pyocutaneous disease due to pathogenic fire, and sprain, contusion and pain.
Chinese date: sweet in taste, warm in nature, and capable of entering spleen and stomach channels, and has the functions of tonifying middle-jiao and Qi, nourishing blood and tranquilization and moderating drug property; modern pharmacology finds that the red dates contain rich nutritional ingredients such as proteins, saccharides, organic acids, vitamin A, vitamin C, various trace calcium, amino acids and the like; has ideal effects of treating the increase of serum transaminase of patients with allergic purpura, anemia, hypertension, acute and chronic hepatitis and liver cirrhosis, preventing blood transfusion reaction and the like; the Chinese date contains triterpenes and cyclic adenosine monophosphate, and has strong cancer inhibition and anti-allergic effects. The fructus Jujubae contains anti-fatigue substances, and has effects of enhancing human endurance, and relieving liver damage caused by toxic substances. The flavonoids compounds in fructus Jujubae have tranquilizing and blood pressure lowering effects.
Cordyceps militaris: the main chemical components and health care function of the cordyceps militaris are similar to those of natural cordyceps sinensis, the cordyceps militaris has the functions of relieving asthma and cough, tonifying yang and tonifying kidney, has good curative effects on emphysema and tracheitis, has the obvious functions of reducing blood sugar and urine sugar, reducing blood pressure and cranial pressure, and also has the functions of resisting bacteria and cancers, enhancing the immune function, moistening the muscles, beautifying the face, eliminating butterfly spots and the like. Clinical studies show that the average serum total cholesterol of patients can be reduced by 17.5 percent (the serum total cholesterol of a control group is reduced by 1.2 percent) before treatment by taking the cordyceps militaris; triglyceride reduction 9.9% (control 6.7%); high density lipoprotein cholesterol (HKLC) was elevated by 27.2% (10.4% in the control group), indicating a more reliable cholesterol lowering effect and an increase in HDL-C. The cordyceps militaris used by Jiangxi pharmaceutical factories is used for 5 hospitals to treat 117 cases of chronic bronchitis and clinical verification is carried out, the result shows that the significant efficiency is 49.6%, the improvement rate is 33.3%, and the total effective rate reaches 82.9%. The cordyceps militaris is used for treating 50 cases of impotence patients by Suzhou medical college-attach college, the total effective rate is 64 percent, both 17-hydroxy and 17-ketone are increased, and the cordyceps militaris is considered to have the functions of improving the function of adrenal cortex, tonifying kidney and strengthening yang and treating impotence. According to the results of 30 cases of chronic renal failure treated by cordyceps militaris in an equal report, after one month of treatment, the renal function of a patient is obviously improved, creatinine and urea in blood after treatment are obviously reduced compared with those before treatment, the creatinine clearance rate is improved, and hemoglobin is increased. 256 cases of chronic viral hepatitis treated by cordyceps militaris in Shanghai and the like have the effective rate of over 80 percent, symptoms, physical signs and liver functions of most patients are improved to different degrees, and the change of serum albumin and SGPT is obvious. The functions of the cordyceps militaris can also prevent and treat complications such as heart, liver, lung, kidney and sexual dysfunction caused by diabetes.
The invention has the following advantages:
the invention skillfully utilizes the effects of promoting blood circulation and removing blood stasis of various components in the formula, can effectively clear and dredge blood vessels, change microcirculation, restore blood vessel elasticity, clear harmful substances accumulated in the blood vessels for a long time, improve blood supply of heart and brain and blood vessels and regulate blood pressure, eliminate microcirculation disturbance and fully improve the blood vessel environment of human bodies, adds vital energy-strengthening and constitution-consolidating medicines such as cordyceps militaris, ginseng, Chinese yam and the like into the ingredients, can fully improve the body function and the immunity and disease resistance, fully utilizes the convenience characteristic of medicinal granules, is convenient to take and drink after being infused in water, is convenient to fully utilize and absorb by the human bodies, plays the maximum value, exerts the synergistic effect among the components to form mutual assistance and complementation, can obviously sense energy improvement, improve the immunity and disease resistance and increase the cardiac muscle function after being absorbed by the human bodies, The composition has the advantages of promoting vasodilatation, accelerating blood circulation, smoothing blood flow, convenient use, no toxic or side effect after long-term administration, no relapse after blood pressure reduction, and no need of other antihypertensive drugs.
Detailed Description
The present invention is described in terms of particular embodiments, other advantages and features of the invention will become apparent to those skilled in the art from the following disclosure, and it is to be understood that the described embodiments are merely exemplary of the invention and that it is not intended to limit the invention to the particular embodiments disclosed. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
The embodiment provides the raw material medicaments of the composition, which comprise the following components in parts by weight: 20 parts of ginseng, 40 parts of medlar, 4 parts of kudzu root, 3 parts of Chinese date, 3 parts of rhizoma polygonati, 6 parts of white gourd, 5 parts of corn stigma, 6 parts of cassia seed, 5 parts of Chinese yam, 2 parts of cape jasmine, 7 parts of chrysanthemum and 6 parts of cordyceps militaris.
The preparation method comprises the following steps:
step one, raw material treatment
Cleaning and airing the raw materials, removing damaged and deteriorated parts, removing kernels from fruit raw materials, weighing the various medicinal materials according to the mass part requirement, and drying to obtain raw medicinal materials;
step two, grinding the powder
Uniformly mixing the raw material medicines, grinding the mixture into powder, sieving the powder, and drying the powder again;
step three, packaging
Sterilizing the powder, and packaging with specification of 0.6 g/bag.
Example 2
The embodiment provides the raw material medicaments of the composition, which comprise the following components in parts by weight: 10 parts of ginseng, 60 parts of medlar, 7 parts of kudzu root, 5 parts of Chinese date, 1 part of rhizoma polygonati, 8 parts of white gourd, 3 parts of corn stigma, 9 parts of cassia seed, 9 parts of Chinese yam, 1 part of gardenia, 7 parts of chrysanthemum and 6 parts of cordyceps militaris.
The preparation method comprises the following steps:
step one, raw material treatment
Cleaning and airing the raw materials, removing damaged and deteriorated parts, removing kernels from fruit raw materials, weighing the various medicinal materials according to the mass part requirement, and drying to obtain raw medicinal materials;
step two, grinding the powder
Uniformly mixing the raw material medicines, grinding the mixture into powder, sieving the powder, and drying the powder again;
step three, packaging
Sterilizing the powder, and packaging with specification of 0.6 g/bag.
Example 3
The embodiment provides the raw material medicaments of the composition, which comprise the following components in parts by weight: 30 parts of ginseng, 30 parts of medlar, 5 parts of kudzu root, 2 parts of Chinese date, 5 parts of rhizoma polygonati, 7 parts of white gourd, 4 parts of corn stigma, 7 parts of cassia seed, 1 part of Chinese yam, 3 parts of gardenia, 9 parts of chrysanthemum and 3 parts of cordyceps militaris.
The preparation method comprises the following steps:
step one, raw material treatment
Cleaning and airing the raw materials, removing damaged and deteriorated parts, removing kernels from fruit raw materials, weighing the various medicinal materials according to the mass part requirement, and drying to obtain raw medicinal materials;
step two, grinding the powder
Uniformly mixing the raw material medicines, grinding the mixture into powder, sieving the powder, and drying the powder again;
step three, packaging
Sterilizing the powder, and packaging with specification of 0.6 g/bag.
Example 4
The embodiment provides the raw material medicaments of the composition, which comprise the following components in parts by weight: 30 parts of ginseng, 30 parts of medlar, 5 parts of kudzu root, 2 parts of Chinese date, 5 parts of rhizoma polygonati, 7 parts of white gourd, 4 parts of corn stigma, 7 parts of cassia seed, 1 part of Chinese yam, 3 parts of gardenia, 9 parts of chrysanthemum and 3 parts of cordyceps militaris.
The preparation method comprises the following steps:
step one, raw material treatment
Cleaning and airing the raw materials, removing damaged and deteriorated parts, removing kernels from fruit raw materials, weighing the various medicinal materials according to the mass part requirement, and drying to obtain raw medicinal materials;
step two, grinding the powder
Uniformly mixing the raw material medicines, grinding the mixture into powder, sieving the powder, and drying the powder again;
step three, packaging
Sterilizing the powder, and packaging with specification of 0.6 g/bag.
Comparative example 1
The difference between the comparative example and the example 1 is that no sealwort is added in the comparative example, and other components and preparation methods are completely the same as the example 1.
Comparative example 2
The difference between the comparative example and the example 1 is that the cordyceps militaris is not added in the comparative example, and other components and the preparation method are completely the same as the example 1.
Test examples
1. General data
A total of 320 patients receiving hypertension, aged 18-45 years, were randomized into 8 groups of 40 individuals, and each of the groups received the compositions of examples 1-4, comparative example 1, and comparative document 2, nifedipine, and a blank control.
2. Diagnostic criteria
The effect is shown: after the blood pressure is normal and stable, the western medicines are reduced and stopped, the product is only taken, and the product is stopped after 3 months, so that the blood pressure can be kept normal and stable, and other antihypertensive medicines are not required to be taken;
improvement: gradually reducing and stopping part of western medicines, keeping the blood pressure normal, reducing and stopping the western medicines, taking the medicine after 3 months, keeping the blood pressure stable, continuing taking the medicine for 6 months, keeping the blood pressure normal and stable, and slightly rising or not rising basically after stopping taking the medicine;
and (4) invalidation: the blood pressure can not be reduced or unstable after the western medicine is reduced.
3. Conditioning method
The medicine is taken by patients, 2-3 bags are taken for the first time, and the specification is as follows: 0.6 g/bag, taking 1 time per morning, adjusting dosage according to blood pressure condition, taking 1 bag/day after blood pressure reaches 120 mm Hg, lowering blood pressure to 110 mm Hg, taking 1 bag for 2-3 days, and continuously taking for 3 months.
4. Conditioning results are shown in Table 1
TABLE 1
Show effect Improvement of life Invalidation
Example 1 39 1 0
Example 2 40 0 0
Example 3 38 2 0
Example 4 40 0 0
Comparative example 1 25 13 2
Comparative example 2 22 15 3
Blank space 0 0 40
Nifedipine 40 0 0
In the above conditioning, 160 patients with hypertension were conditioned with the drug of the present invention, with the following results: 157 cases of significant effect, the significant efficiency is 98.13%; the conversion rate is 1.87 percent for 3 cases; the total effective rate is more than 100 percent in 0 cases of invalidity; the effect of the comparison document 1 and the comparison document 2 is obviously lower than that of the comparison document 1 without adding the sealwort and the cordyceps militaris respectively.
Case 1
The patient history of hypertension is 55 years old and more than 15 years old, the liver and kidney have side effects, the blood pressure is 170 mm Hg for a long time, the neck is stiff, the product of the invention 2 is taken after the patient is taken, 3 bags per day are taken for the first time, western medicines are stopped, the blood pressure is 140 mm Hg after the patient is continuously taken for 1 month, and the blood pressure is reduced to 120 mm Hg after the patient is continuously taken for two months.
Case 2
Zhangzhi, the history of hypertension of 50 years old and 15 years old, the blood pressure is 160 mm Hg for a long time, the blood pressure is reduced after long-term taking of nifedipine, the product of the invention in the embodiment 2 is taken for the first time for 3 bags per day, western medicines are stopped, after continuous taking for 1 week, the blood pressure is 120 mm Hg at present, the continuous taking amount is changed to 1 bag per day, the blood pressure is reduced to 110 mm Hg after one month, after continuous taking for 1 bag for 3 days, and after 3 months of medicine stopping, blood medicine does not rebound.
Although the invention has been described in detail above with reference to a general description and specific examples, it will be apparent to one skilled in the art that modifications or improvements may be made thereto based on the invention. Accordingly, such modifications and improvements are intended to be within the scope of the invention as claimed.

Claims (8)

1. A composition for regulating hypertension is characterized by comprising ginseng, medlar, kudzu root, Chinese date, sealwort, white gourd, corn stigma, cassia seed, Chinese yam, gardenia, chrysanthemum and cordyceps militaris.
2. The composition for conditioning hypertension according to claim 1, wherein the raw material drugs of the composition comprise the following components in parts by weight: 10-30 parts of ginseng, 30-60 parts of medlar, 4-7 parts of kudzu root, 2-5 parts of Chinese date, 1-5 parts of rhizoma polygonati, 6-8 parts of white gourd, 3-5 parts of corn stigma, 6-9 parts of cassia seed, 1-9 parts of Chinese yam, 1-3 parts of gardenia, 7-9 parts of chrysanthemum and 3-6 parts of cordyceps militaris.
3. The composition for conditioning hypertension according to claim 1, wherein the raw material medicines of the composition comprise the following components in parts by weight: 20 parts of ginseng, 40 parts of medlar, 4 parts of kudzu root, 3 parts of Chinese date, 3 parts of rhizoma polygonati, 6 parts of white gourd, 5 parts of corn stigma, 6 parts of cassia seed, 5 parts of Chinese yam, 2 parts of cape jasmine, 7 parts of chrysanthemum and 6 parts of cordyceps militaris.
4. The composition for conditioning hypertension according to claim 1, wherein the raw material medicines of the composition comprise the following components in parts by weight: 10 parts of ginseng, 60 parts of medlar, 7 parts of kudzu root, 5 parts of Chinese date, 1 part of rhizoma polygonati, 8 parts of white gourd, 3 parts of corn stigma, 9 parts of cassia seed, 9 parts of Chinese yam, 1 part of gardenia, 7 parts of chrysanthemum and 6 parts of cordyceps militaris.
5. The composition for conditioning hypertension according to claim 1, wherein the raw material medicines of the composition comprise the following components in parts by weight: 30 parts of ginseng, 30 parts of medlar, 5 parts of kudzu root, 2 parts of Chinese date, 5 parts of rhizoma polygonati, 7 parts of white gourd, 4 parts of corn stigma, 7 parts of cassia seed, 1 part of Chinese yam, 3 parts of gardenia, 9 parts of chrysanthemum and 3 parts of cordyceps militaris.
6. A method of preparing a composition for regulating hypertension according to any one of claims 1 to 5, which comprises:
step one, raw material treatment
Cleaning raw materials, air drying, removing damaged and deteriorated parts, removing kernels from fruit raw materials, weighing raw materials, and oven drying to obtain raw medicinal materials;
step two, grinding the powder
Uniformly mixing the raw material medicines, grinding the mixture into powder, sieving the powder, and drying the powder again;
step three, packaging
Sterilizing the powder, and packaging.
7. The method for preparing a composition for regulating hypertension according to claim 6, wherein, in the first step, the drying moisture is less than 5%.
8. The method for preparing the composition for conditioning hypertension, according to the claim 6, is characterized in that in the third step, the specification is 0.6 g/bag after packaging.
CN202210809435.5A 2022-07-11 2022-07-11 Composition for regulating hypertension and preparation method thereof Pending CN115040612A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115428952A (en) * 2022-09-27 2022-12-06 河南磐康健康管理股份有限公司 Composition for preventing and improving diseases related to microcirculation disturbance, preparation method and application thereof

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112690390A (en) * 2021-01-08 2021-04-23 江苏中堂健康管理有限公司 Ginseng cordyceps militaris solid beverage and preparation method thereof
CN113855766A (en) * 2021-10-09 2021-12-31 江苏华尔康生物制品有限公司 Gingko and cordyceps militaris granules capable of regulating blood pressure

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112690390A (en) * 2021-01-08 2021-04-23 江苏中堂健康管理有限公司 Ginseng cordyceps militaris solid beverage and preparation method thereof
CN113855766A (en) * 2021-10-09 2021-12-31 江苏华尔康生物制品有限公司 Gingko and cordyceps militaris granules capable of regulating blood pressure

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115428952A (en) * 2022-09-27 2022-12-06 河南磐康健康管理股份有限公司 Composition for preventing and improving diseases related to microcirculation disturbance, preparation method and application thereof

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