CN109528953A - There is a kind of pair of microcirculation in human body the grass that crosses of improvement result to collect Chinese medicine plant composition - Google Patents
There is a kind of pair of microcirculation in human body the grass that crosses of improvement result to collect Chinese medicine plant composition Download PDFInfo
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Abstract
The present invention relates to plant health formulation arts, there is especially a kind of pair of microcirculation in human body the grass that crosses of improvement result to collect Chinese medicine plant composition, component including following mass fraction: 1~5 part of rhizoma polygonati, 25~36 parts of Radix Notoginseng, 25~38 parts of wax gourd, 7~15 parts of jujube (jujube), 10~20 parts of fructus lycii, ginseng (artificial growth, 5 years or less) 0.5~7 part, 18~28 parts of Semen Coicis, 15~30 parts of longan, 6~14 parts of sea-buckthorn, 2~8 parts of Chinese yam, 2~7 parts of mushroom, each group lease making probiotics fermention is made.Each raw material of the invention is that medicinal and edible plant, Chinese medicine composition have no toxic side effect, and microcirculation disorder can thoroughly be dredged and be improved to Chinese medicine composition；The Chinese medicine composition of offer is the probiotics fermention compound Chinese medicinal preparation for improving microcirculation in human body obstacle by crushing, water, sterilizing, fermentation, drying, crushing, preparation being added to be made；Fermented tcm preparation method is simple, and preparation cost is low, is conducive to promote and apply.
Description
Technical field
The present invention relates to plant health formulation art, especially a kind of pair of microcirculation in human body to cross Cao Ji with improvement result
Chinese medicinal plant composition.
Background technique
The major function of microcirculation be take away metabolite to tissue supply's oxygen and nutriment, once the microcirculation of human body
Obstacle occurs, corresponding organization system or internal organs will be affected and the function that cannot bring into normal play, be easy for causing
The aging of human body, the disorder of immune function and the generation of disease.
Under normal circumstances, microcirculatory blood flow and tissue, organ metaboilic level adapt to, and make one internal each organ physiology
Function is operated normally.Because the capillary of people is superfine extremely long, and velocity of blood flow therein is extremely slow, per second to flow
0.41 millimeter.In so long blood vessel, often there is impurity muddiness in blood, as cholesterol, alcohol, nicotine, drug are residual
Slag, chemical residue etc., they not only make vascular wall thicken, and are frequently occluded blood vessel sometimes, cause blood operation unsmooth.Therefore,
If human body does not notice that health care prevents, microcirculation is easy to that obstacle occurs, and generates stasis, and metabolism cannot proceed normally, gently
Then body function is caused to degenerate, the generation of disease is resulted in when serious.
We can observe under the microscope, and the capillary of people is very thin, only the 1/20 of hairline, but these into
The most important blood vessel of the human life activity that goes is but very long, it has been connected more than 96000 kilometers, and blood stream therein
Speed is very slow, per second to flow 0.4 to 1 millimeter, therefore in so long blood vessel, micro- to follow if human body not health care prevents
Ring is easy to that serious hindrance occurs, and generates stasis.
With advancing age, the physical function of human body is gradually degenerated, and blood viscosity increases, and blood flow velocity slows down, blood
May be retarded by silt in capillary, or even blocking, make histocyte can not eubolism, cell had both been unable to get sufficiently
Nutrient, and waste cannot be discharged in time, to influence the performance of human normal physiological function, at this moment people is easy to that disease occurs
Disease.
Microcirculation is good, and myocardial infarction is few；Microcirculation process, whole body health.Microcirculation is almost origin of hundreds of diseases, sound
Microcirculation function is to guarantee that internal vitals execute the primary premise of normal function.Therefore, improve microcirculation, even more protection body
The prerequisite of body health is also increasingly obtained by the method trend that plant beverage complementary therapy treats microcirculation disorder now
Social extraneous approval.However, existing Chinese medicinal plant composition active force in using effect is poor, effect is unobvious, no
The effect for the treatment of can be properly arrived at.
Summary of the invention
The present invention one of to solve above-mentioned technical problem used by technical solution be: a kind of pair of microcirculation in human body, which has, to be changed
Grass collection Chinese medicine plant composition, including following components: rhizoma polygonati, Radix Notoginseng, wax gourd, jujube (jujube), fructus lycii, ginseng are crossed in kind effect
(artificial growth, 5 years or less), Semen Coicis, longan, sea-buckthorn, Chinese yam, mushroom, each group lease making probiotics fermention are made.
Preferably, there is a kind of pair of microcirculation in human body the grass that crosses of improvement result to collect Chinese medicine plant composition, including following matter
Measure the component of number: 1~5 part of rhizoma polygonati, 25~36 parts of Radix Notoginseng, 25~38 parts of wax gourd, 7~15 parts of jujube (jujube), fructus lycii 10~20
Part, 0.5~7 part of ginseng (artificial growth, 5 years or less), 18~28 parts of Semen Coicis, 15~30 parts of longan, 6~14 parts of sea-buckthorn, Chinese yam
2~8 parts, 2~7 parts of mushroom, each group lease making probiotics fermention is made.
Preferably, there is a kind of pair of microcirculation in human body the grass that crosses of improvement result to collect Chinese medicine plant composition, including following matter
Measure number component: 3 parts of rhizoma polygonati, 30 parts of Radix Notoginseng, 33 parts of wax gourd, 10 parts of jujube (jujube), 15 parts of fructus lycii, ginseng (artificial growth, five
Year or less) 4 parts, 23 parts of Semen Coicis, 25 parts of longan, 10 parts of sea-buckthorn, 6 parts of Chinese yam, 5 parts of mushroom, each group lease making probiotics fermention
It is made.
A kind of pair of microcirculation in human body has the preparation method for crossing grass collection Chinese medicine plant composition of improvement result, including as follows
Step:
S1: raw material is chosen
Each raw material: rhizoma polygonati, Radix Notoginseng, wax gourd, jujube (jujube), fructus lycii, (artificial kind of ginseng is weighed by above-mentioned mass fraction composition
Plant, 5 years or less), Semen Coicis, longan, sea-buckthorn, Chinese yam, mushroom；Each component in the present invention passes through monarch drug in a prescription, ministerial drug mutual cooperation energy
Enough have effects that activating microcirculation and removing stasis medicinal, dredging the channel, except the dredging microcirculation such as cold dehumidifying, benefiting qi and nourishing blood.
Chinese medicine composition of the invention can be dredged thoroughly and improve microcirculation disorder, accomplish " prevention of diseae, both disease had been preapred for an unfavorable turn of events ",
Accomplish treating both manifestation and root cause of disease；Fermented tcm preparation method of the invention is simple, and preparation cost is low, is conducive to promote and apply.
This plant society raw material is for improving by crushing plus water, sterilizing, fermentation, drying, crushing, preparation is made
The probiotics fermention compound Chinese medicinal preparation of microcirculation in human body obstacle.Compared with traditional dredging microcirculation health drink, the present invention
The probiotics fermention compound Chinese medicinal preparation of improvement microcirculation in human body obstacle can improve curative effect, reduce dosage, improve mouthfeel, be convenient for
Patient takes；And method is simple, at low cost, is conducive to the advantages of promoting and applying.
Various medicinal materials are reasonable using compatibility in the present invention, and complementary and collaboration can be played between each Chinese medicine component and is promoted and is made
With, efficacy stability, the efficacy of a drug are rapid, easy to use, collection improve and treatment the dizziness due to caused by microcirculation disorder, headache, insomnia,
The nervous systems such as dreaminess, decrease of memory, neurasthenia, deficiency myocardial blood supply generate uncomfortable in chest, nervous, cardiac arrhythmia, angina pectoris
Etc. coronary heart disease etc. disease of cardiovascular systems and respiratory disease, disease of digestive system, endocrine system disease, uropoiesis
A variety of diseases such as genital system diseases, muscle arthrosis systemic disease and gynecologic tract disease.
S2: it is mixed
Water is added in products therefrom into S1 and stirs evenly to obtain mixture；
S3: gained mixture in S2 is put into progress low temperature sterilization processing in sterilization tank；
S4: it is sealed by fermentation
It is inoculated with probiotics strain in gained mixture into S3, after adding water and stirring uniformly, is sealed by fermentation；
S5: drying
The mixture obtained after fermentation is subjected to drying and processing；
S6: it crushes
Mixture after drying is subjected to ultra-fine grinding processing；
S7: finished product processing
Any one or more of electuary, tablet, pill, capsule is made in mixture obtained in S6, obtains finished product.
Preferably, it needs to carry out grinding and sieving processing before each component mixing in the S1.
Preferably, the mesh number of the sieve is 40-60 mesh.
Preferably, probiotics strain described in the S4 is Bifidobacterium, any one or two kinds in Bacillus acidi lactici；Institute
The temperature for stating drying and processing in S5 is 170 DEG C~190 DEG C, is dried to water content < 3% in fermentation gained mixture；In the S6
Ultra-fine grinding processing is carried out using nanometer pulverizer.
Preferably, it is sealed by fermentation condition are as follows: 40 DEG C~50 DEG C of fermentation temperature, fermentation time 5~10 days；The water control of addition
Be made as: water content is 25%~45% in the powder obtained after adding water and stirring.
Preferably, the low temperature sterilization condition of the S3 is as follows: subzero 20-30 DEG C of sterilising temp, the processing time 30~
60min。
The present invention has the beneficial effects that
1, each raw material of the invention is that medicinal and edible plant, Chinese medicine composition have no toxic side effect, and Chinese medicine composition can be dredged thoroughly
Logical and improvement microcirculation disorder, accomplishes " prevention of diseae, both disease had been preapred for an unfavorable turn of events ", accomplishes treating both manifestation and root cause of disease.
2, Chinese medicine composition provided by the invention is by crushing, water, sterilizing, fermentation, drying, crushing, preparation being added to be made
For improving the probiotics fermention compound Chinese medicinal preparation of microcirculation in human body obstacle.
3, fermented tcm preparation method of the invention is simple, and preparation cost is low, is conducive to promote and apply.
4, curative effect can be improved in the probiotics fermention compound Chinese medicinal preparation of improvement microcirculation in human body obstacle of the invention, subtracted
Dosage when using less, and mouthfeel improvement has been carried out, it facilitates patients.
Specific embodiment
In order to clarify the technical characteristics of the invention, being explained in detail below by specific embodiment the present invention
It states.
Cross careless collect Chinese medicine plant composition, including following components of a kind of pair of microcirculation in human body with improvement result: rhizoma polygonati,
Radix Notoginseng, wax gourd, jujube (jujube), fructus lycii, ginseng (artificial growth, 5 years or less), Semen Coicis, longan, sea-buckthorn, Chinese yam, mushroom, it is described
Each group lease making probiotics fermention is made.Chinese medicine composition of the invention has no toxic side effect, each component in used formula
Nutrition, medical value or drug pharmacology are described as follows.
Chinese yam, sweet in flavor, mild-natured, returns spleen, lung, kidney channel, tonifying spleen nourishing the stomach, engender liquid and benefic lung, kidney tonifying arresting seminal emission are used for spleen eating less,
Endless diarrhea, the deficiency syndrome of the lung are breathed with cough, emission due to the kidney deficiency, leukorrhagia, frequent micturition, and abnormal heat is quenched one's thirst, and Dioscin is contained in Chinese yam, have eliminating the phlegm, desensitization,
Anti-inflammatory, lipid-loweringing, it is antitumor the effects of.
Fructus lycii: it is sweet in flavor, it is mild-natured.Return liver and kidney channel.It is nourishing liver and kidney, benefiting shrewd head.For consumption consumptive loss, soreness of waist and knee joint, dizziness
Tinnitus, Heat Diabetes, blood deficiency chlorosis, blurred vision.
Jujube (jujube), tonifying spleen stomach function regulating, nourishing generate fluid adjust battalion to defend, and solve poisoning of drug.Control stomach void deficiency of food, the weak loose stool of spleen, qi-blood-body fluid
Deficiency, disharmony between ying and wei, palpitation and severe palpitation.Married woman's stolen goods are hot-tempered；Main trusted subordinate's perverse trend supports spleen in peace, helps 12 warps.Flat stomach gas leads to nine orifices, mends
Lack gas, few body fluid, insufficient, frightened, heaviness of limbs and hundred medicines in body.Collective Notes to the Canon of Materia medica: evil spirit's Aconitum Carmichaeli." Bie Lu ": bowl spares benefit
Gas, strength are treated and are hanged under the heart except unhappiness, the out-of-the-way nettle of intestines " medicine to ": killing the male poison in monkshood, day.Meng's numerous: main body fluid complementing washes trusted subordinate's perverse trend,
With hundred poisoning of druies, lead to nine orifices, tonifying for the deficiency gas cooks and mends stomach, and QI invigorating first in fertilizer, children suffer from autumn dysentery, eats with worm jujube, good." solar corona
Sub- book on Chinese herbal medicine ": moistening herat and lung is only coughed.Tonifying five zang organs control consumptive disease damage, remove stomach tinea gas." pearl sac ": warm stomach.Li Gao: temperature is passed through with tonifying spleen
Deficiency, it is sweet with slow negative blood and yin-yang, adjust battalion to defend, born fluid." drugization justice ": blood-nourishing tonifying liver." book on Chinese herbal medicine is new again ": tonifying middle-Jiao and Qi,
Nourshing kidney warm stomach, controls the deficiency of Yin." middle traditional Chinese medicines plant illustrated handbook ": allergic purpura disease, anaemia and hypertension are controlled.
Rhizoma polygonati has the effect of boosting qi and nourishing yin, invigorating the spleen, moistening lung, kidney-nourishing.It is usually used in deficiency of spleen-QI and stomach-QI, fatigue and asthenia, stomach-Yin is not
Foot, dry deficiency of food, deficiency syndrome of the lung cough caused by dryness, overstrain cough hemoptysis, asthenia of essence and blood, soreness and weakness of waist and knees, poliosis, Heat Diabetes.
Radix Notoginseng, sweet in flavor, slight bitter；Warm-natured, return liver warp, stomach meridian, the heart channel of Hang-Shaoyin, lung channel, large intestine channel is mainly used for abdominal mass lump in the abdomen, the stasis of blood
The diseases such as blood menostasis, dyspepsia distending pain, can build up health, and prevent coronary heart disease and angina pectoris, removing blood stasis and hemostasis, analgesic therapy of invigorating blood circulation.Safflower, gas
Taste: sweet and neutral, it is nontoxic, it is smouldered the major functions: worrying, unhappy not dissipate, promoting blood circulation, long term usage makes us heart happiness, and controls palpitation with fear.
Mushroom: cold in nature, mildly bitter flavor the effect of advantageous liver benefit stomach, contains vitamin D abundant, and lentinan can improve auxiliary
Property T cell vigor and enhance human body fluid immune function, the anti-curing cancers of mushroom it is in extensive range, have been used for clinical treatment, it is fragrant
Mushroom also contains multivitamin, minerals, and to human metabolism is promoted, improving organism adaptation power has great role, and mushroom is also
Are risen by therapeutic effect, and can be used for indigestion, constipation, weight-reducing for diabetes, pulmonary tuberculosis, catarrhal jaundice, neuritis etc. etc..
Sea-buckthorn, it is sour；It is puckery；It is warm-natured；It is relieving cough and reducing sputum；Stomach strengthening and digestion promoting；Promoting blood circulation to remove blood stasis.Main coughing with a lot of sputum；Pulmonary abscess；Digestion is not
It is good；Dyspeptic abdominalgia；Stomachache；Enteritis；Amenorrhoea；It beats the stasis of blood swell.
A kind of pair of microcirculation in human body has the preparation method for crossing grass collection Chinese medicine plant composition of improvement result, including as follows
Step:
S1: raw material is chosen
Weigh each raw material by above-mentioned mass fraction composition: 3 parts of rhizoma polygonati, 30 parts of Radix Notoginseng, 33 parts of wax gourd, 10 parts of jujube (jujube),
15 parts of fructus lycii, 4 parts of ginseng (artificial growth, 5 years or less), 23 parts of Semen Coicis, 25 parts of longan, 10 parts of sea-buckthorn, 6 parts of Chinese yam, mushroom 5
Part, each group lease making probiotics fermention is made.
Chinese medicine composition of the invention can be dredged thoroughly and improve microcirculation disorder, accomplish " prevention of diseae, both disease had been preapred for an unfavorable turn of events ",
Accomplish treating both manifestation and root cause of disease；Fermented tcm preparation method of the invention is simple, and preparation cost is low, is conducive to promote and apply.
This plant society raw material is for improving by crushing plus water, sterilizing, fermentation, drying, crushing, preparation is made
The probiotics fermention compound Chinese medicinal preparation of microcirculation in human body obstacle.Compared with traditional dredging microcirculation health drink, the present invention
The probiotics fermention compound Chinese medicinal preparation of improvement microcirculation in human body obstacle can improve curative effect, reduce dosage, improve mouthfeel, be convenient for
Patient takes；And method is simple, at low cost, is conducive to the advantages of promoting and applying.
Various medicinal materials are reasonable using compatibility in the present invention, and complementary and collaboration can be played between each Chinese medicine component and is promoted and is made
With, efficacy stability, the efficacy of a drug are rapid, easy to use, collection improve and treatment the dizziness due to caused by microcirculation disorder, headache, insomnia,
The nervous systems such as dreaminess, decrease of memory, neurasthenia, deficiency myocardial blood supply generate uncomfortable in chest, nervous, cardiac arrhythmia, angina pectoris
Etc. coronary heart disease etc. disease of cardiovascular systems and respiratory disease, disease of digestive system, endocrine system disease, uropoiesis
A variety of diseases such as genital system diseases, muscle arthrosis systemic disease and gynecologic tract disease.
S2: it is mixed
Water is added in products therefrom into S1 and stirs evenly to obtain mixture；
S3: gained mixture in S2 is put into high-temperature sterilization and inwardly carries out high-temperature sterilization processing；
S4: it is sealed by fermentation
It is inoculated with probiotics strain in gained mixture into S3, after adding water and stirring uniformly, is sealed by fermentation；
S5: drying
The mixture obtained after fermentation is subjected to drying and processing；
S6: it crushes
Mixture after drying is subjected to ultra-fine grinding processing；
S7: finished product processing
Any one or more of electuary, tablet, pill, capsule is made in mixture obtained in S6, obtains finished product.
Preferably, it needs to carry out grinding and sieving processing before each component mixing in the S1.
Preferably, the mesh number of the sieve is 40-60 mesh.
Preferably, probiotics strain described in the S4 is Bifidobacterium, any one or two kinds in Bacillus acidi lactici；Institute
The temperature for stating drying and processing in S5 is 170 DEG C~190 DEG C, is dried to water content < 3% in fermentation gained mixture；In the S6
Ultra-fine grinding processing is carried out using nanometer pulverizer.
Preferably, it is sealed by fermentation condition are as follows: 40 DEG C~50 DEG C of fermentation temperature, fermentation time 5~10 days；The water control of addition
Be made as: water content is 25%~45% in the powder obtained after adding water and stirring.
Preferably, the low temperature sterilization condition of the S3 is as follows: subzero 20-30 DEG C of sterilising temp, the processing time 30~
60min。
Embodiment 1:
Preferably, there is a kind of pair of microcirculation in human body the grass that crosses of improvement result to collect Chinese medicine plant composition, including following mass parts
Several components: 3 parts of rhizoma polygonati, 30 parts of Radix Notoginseng, 33 parts of wax gourd, 10 parts of jujube (jujube), 15 parts of fructus lycii, ginseng (artificial growth, 5 years with
Under) 4 parts, 23 parts of Semen Coicis, 25 parts of longan, 10 parts of sea-buckthorn, 6 parts of Chinese yam, 5 parts of mushroom, each group lease making probiotics fermention is made.
A kind of pair of microcirculation in human body has the preparation method for crossing grass collection Chinese medicine plant composition of improvement result, including as follows
Step:
S1: raw material is chosen
Each raw material is weighed by above-mentioned mass fraction composition, 10g is a mass parts: rhizoma polygonati, Radix Notoginseng, wax gourd, jujube (jujube), Chinese holly
Qi, ginseng (artificial growth, 5 years or less), Semen Coicis, longan, sea-buckthorn, Chinese yam, mushroom；
S2: it is mixed
Water is added in products therefrom into S1 and stirs evenly to obtain mixture；
S3: gained mixture in S2 is put into high-temperature sterilization and inwardly carries out high-temperature sterilization processing；
S4: it is sealed by fermentation
It is inoculated with probiotics strain in gained mixture into S3, after adding water and stirring uniformly, is sealed by fermentation；
S5: drying
The mixture obtained after fermentation is subjected to drying and processing；
S6: it crushes
Mixture after drying is subjected to ultra-fine grinding processing；
S7: finished product processing
Any one or more of electuary, tablet, pill, capsule is made in mixture obtained in S6, obtains finished product.
Preferably, it needs to carry out grinding and sieving processing before each component mixing in the S1.
Preferably, the mesh number of the sieve is 40-60 mesh.
Preferably, probiotics strain described in the S4 is Bifidobacterium, any one or two kinds in Bacillus acidi lactici；Institute
The temperature for stating drying and processing in S5 is 170 DEG C~190 DEG C, is dried to water content < 3% in fermentation gained mixture；In the S6
Ultra-fine grinding processing is carried out using nanometer pulverizer.
Preferably, it is sealed by fermentation condition are as follows: 40 DEG C~50 DEG C of fermentation temperature, fermentation time 5~10 days；The water control of addition
Be made as: water content is 25%~45% in the powder obtained after adding water and stirring.
Preferably, the low temperature sterilization condition of the S3 is as follows: subzero 20-30 DEG C of sterilising temp, the processing time 30~
60min。
Embodiment 2:
Preferably, there is a kind of pair of microcirculation in human body the grass that crosses of improvement result to collect Chinese medicine plant composition, including following mass parts
Several components: 1 part of rhizoma polygonati, 25 parts of Radix Notoginseng, 25 parts of wax gourd, 7 parts of jujube (jujube), 10 parts of fructus lycii, ginseng (artificial growth, 5 years with
Under) 0.5 part, 18 parts of Semen Coicis, 15 parts of longan, 6 parts of sea-buckthorn, 2 parts of Chinese yam, 2 parts of mushroom, each group lease making probiotics fermention system
At.
Preparation method is same as Example 1.
Embodiment 3:
Preferably, there is a kind of pair of microcirculation in human body the grass that crosses of improvement result to collect Chinese medicine plant composition, including following mass parts
Several components: 2 parts of rhizoma polygonati, 28 parts of Radix Notoginseng, 29 parts of wax gourd, 8 parts of jujube (jujube), 13 parts of fructus lycii, ginseng (artificial growth, 5 years with
Under) 2,20 parts of Semen Coicis, 18 parts of longan, 8 parts of sea-buckthorn, 4 parts of Chinese yam, 3 parts of mushroom, each group lease making probiotics fermention is made.
Preparation method is same as Example 1.
Embodiment 4:
Preferably, there is a kind of pair of microcirculation in human body the grass that crosses of improvement result to collect Chinese medicine plant composition, including following mass parts
Several components: 4 parts of rhizoma polygonati, 33 parts of Radix Notoginseng, 35 parts of wax gourd, 13 parts of jujube (jujube), 17 parts of fructus lycii, ginseng (artificial growth, 5 years with
Under) 6 parts, 26 parts of Semen Coicis, 27 parts of longan, 12 parts of sea-buckthorn, 7 parts of Chinese yam, 6 parts of mushroom, each group lease making probiotics fermention is made.
Preparation method is same as Example 1.
Embodiment 5:
Preferably, there is a kind of pair of microcirculation in human body the grass that crosses of improvement result to collect Chinese medicine plant composition, including following mass parts
Several components: 5 parts of rhizoma polygonati, 36 parts of Radix Notoginseng, 38 parts of wax gourd, 15 parts of jujube (jujube), 20 parts of fructus lycii, ginseng (artificial growth, 5 years with
Under) 7 parts, 28 parts of Semen Coicis, 30 parts of longan, 14 parts of sea-buckthorn, 8 parts of Chinese yam, 7 parts of mushroom, each group lease making probiotics fermention is made.
Preparation method is same as Example 1.
Effete test embodiment
Influence experiment of the Chinese materia medica preparation that embodiment 1 provides to Rat Experimental model of microcirculation obstacle.
Experimentation: rat 72,250 ± 20g of weight, half male and half female, certain Experimental Animal Center is randomly divided into following three
Group: model control group, high dose group, low dose group, every group 24.
The Chinese materia medica preparation that high dose group and low dose group rat oral gavage embodiment 1 provide, brews into solution, high agent with boiled water
The dosage of amount group is 0.12g crude drug amount/kg, and the dosage of low dose group is 0.03g crude drug amount/kg, control rats stomach-filling pure water
10ml/kg.The daily stomach-filling of each group 2 times, continuous 2 weeks.All rats open cranium window, and give 10% dextran from rat femoral vein,
Dosage is 10ml/kg, causes model of microcirculation obstacle, measures each group rat tissue blood flow with Laser-doppler flowentry method
Amount, the blood flow velocity before record modeling and after modeling when 1,8,25,50min.It is with the blood flow before each group injection dextran
1, compared with before modeling, observe the variation of its blood flow.Concrete outcome is referring to table 1.
The comparison of 1 each group rat cerebral blood flow (CBF) of table
Note: compared with model control group,★P<0.05；Compared with normal,★P<0.01。
For table 1 the results show that before injection dextran, each group cerebral blood flow (CBF) is almost the same.After each group injects dextran, make
At microcirculation disorder, Cerebral microcirculation blood flow decline shows brain microcirculation disorder modeling success.In addition after modeling 25min, administration
The cerebral blood flow (CBF) of amount group rat is improved, although horizontal before not returning to modeling, compared with model group, has conspicuousness
Difference (P < 0.05) or extremely significant sex differernce (P < 0.01).
Toxicological test example
The Chinese materia medica preparation provided with the present embodiment 1 carries out anxious poison experiment to animal: major mouse diet activity is normal during test, hair
Coloured light pool, none is dead.
The dosis tolerata for the Chinese materia medica preparation that rat provides the present embodiment 1 is 72g crude drug amount/kg, and rat is resistance to the maximum of people
It is 600 times by amount multiple, is taken very safe.
Above-mentioned specific embodiment cannot function as limiting the scope of the invention, for the technology people of the art
For member, any alternate modification or transformation made to embodiment of the present invention are fallen within the scope of protection of the present invention.
Place is not described in detail by the present invention, is the well-known technique of those skilled in the art of the present technique.
Claims (9)
1. there is a kind of pair of microcirculation in human body the grass that crosses of improvement result to collect Chinese medicine plant composition, it is characterised in that: including following
Component: rhizoma polygonati, Radix Notoginseng, wax gourd, jujube (jujube), fructus lycii, ginseng (artificial growth, 5 years or less), Semen Coicis, longan, sea-buckthorn, mountain
Medicine, mushroom, each group lease making probiotics fermention are made.
2. there is a kind of pair of microcirculation in human body according to claim 1 the grass that crosses of improvement result to collect Chinese medicine plant composition,
It is characterized by comprising the components of following mass fraction: 1~5 part of rhizoma polygonati, 25~36 parts of Radix Notoginseng, 25~38 parts of wax gourd, jujube are (big
Jujube) 7~15 parts, 10~20 parts of fructus lycii, 0.5~7 part of ginseng (artificial growth, 5 years or less), 18~28 parts of Semen Coicis, longan 15~
30 parts, 6~14 parts of sea-buckthorn, 2~8 parts of Chinese yam, 2~7 parts of mushroom, each group lease making probiotics fermention are made.
3. there is a kind of pair of microcirculation in human body according to claim 2 the grass that crosses of improvement result to collect Chinese medicine plant composition,
It is characterized by comprising the components of following mass fraction: 3 parts of rhizoma polygonati, 30 parts of Radix Notoginseng, 33 parts of wax gourd, 10 parts of jujube (jujube), fructus lycii
15 parts, 4 parts of ginseng (artificial growth, 5 years or less), 23 parts of Semen Coicis, 25 parts of longan, 10 parts of sea-buckthorn, 6 parts of Chinese yam, 5 parts of mushroom, institute
Each group lease making probiotics fermention is stated to be made.
4. a kind of pair of microcirculation in human body has the preparation method for crossing grass collection Chinese medicine plant composition of improvement result, feature exists
In: include the following steps:
S1: raw material is chosen
Each raw material: rhizoma polygonati, Radix Notoginseng, wax gourd, jujube (jujube), fructus lycii, (artificial kind of ginseng is weighed by above-mentioned mass fraction composition
Plant, 5 years or less), Semen Coicis, longan, sea-buckthorn, Chinese yam, mushroom；
S2: it is mixed
Water is added in products therefrom into S1 and stirs evenly to obtain mixture；
S3: gained mixture in S2 is put into progress low temperature sterilization processing in sterilization tank；
S4: it is sealed by fermentation
It is inoculated with probiotics strain in gained mixture into S3, after adding water and stirring uniformly, is sealed by fermentation；
S5: drying
The mixture obtained after fermentation is subjected to drying and processing；
S6: it crushes
Mixture after drying is subjected to ultra-fine grinding processing；
S7: finished product processing
Any one or more of electuary, tablet, pill, capsule is made in mixture obtained in S6, obtains finished product.
5. there is a kind of pair of microcirculation in human body according to claim 4 the grass that crosses of improvement result to collect Chinese medicine plant composition
Preparation method, it is characterised in that: need to carry out grinding and sieving processing before each component mixing in the S1.
6. there is a kind of pair of microcirculation in human body according to claim 5 the grass that crosses of improvement result to collect Chinese medicine plant composition
Preparation method, it is characterised in that: the mesh number of the sieve is 40-60 mesh.
7. there is a kind of pair of microcirculation in human body according to claim 4 the grass that crosses of improvement result to collect Chinese medicine plant composition
Preparation method, it is characterised in that: probiotics strain described in the S4 be Bifidobacterium, in Bacillus acidi lactici any one or two
Kind；The temperature of drying and processing is 170 DEG C~190 DEG C in the S5, is dried to water content < 3% in fermentation gained mixture；It is described
Ultra-fine grinding processing is carried out using nanometer pulverizer in S6.
8. there is a kind of pair of microcirculation in human body according to claim 4 the grass that crosses of improvement result to collect Chinese medicine plant composition
Preparation method, it is characterised in that: be sealed by fermentation condition are as follows: 40 DEG C~50 DEG C of fermentation temperature, fermentation time 5~10 days；It is added
Water control are as follows: water content is 25%~45% in the powder obtained after adding water and stirring.
9. there is a kind of pair of microcirculation in human body according to claim 4 the grass that crosses of improvement result to collect Chinese medicine plant composition
Preparation method, it is characterised in that: the low temperature sterilization condition of the S3 is as follows: subzero 20-30 DEG C of sterilising temp, the processing time 30~
60min。
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109793132A (en) * | 2019-04-03 | 2019-05-24 | 吉林省玖壹农业科技发展有限公司 | A kind of degrading the channel improves the liquid beverage and preparation method thereof of microcirculation |
| CN113142590A (en) * | 2021-03-24 | 2021-07-23 | 广东丽姿生物科技有限公司 | Composition for improving microcirculation and preparation method thereof |
| CN114306532A (en) * | 2022-01-10 | 2022-04-12 | 赵现坡 | Traditional Chinese medicine composition for improving microcirculation and enhancing immunity and preparation method thereof |
-
2019
- 2019-01-16 CN CN201910039923.0A patent/CN109528953A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109793132A (en) * | 2019-04-03 | 2019-05-24 | 吉林省玖壹农业科技发展有限公司 | A kind of degrading the channel improves the liquid beverage and preparation method thereof of microcirculation |
| CN113142590A (en) * | 2021-03-24 | 2021-07-23 | 广东丽姿生物科技有限公司 | Composition for improving microcirculation and preparation method thereof |
| CN114306532A (en) * | 2022-01-10 | 2022-04-12 | 赵现坡 | Traditional Chinese medicine composition for improving microcirculation and enhancing immunity and preparation method thereof |
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