CN104013850A

CN104013850A - Pharmaceutical composition for relieving malaise after chemoradiotherapy and preparation method thereof

Info

Publication number: CN104013850A
Application number: CN201410282183.0A
Authority: CN
Inventors: 刘洁; 张淑玲; 张佩娟
Original assignee: Individual
Current assignee: Individual
Priority date: 2014-06-23
Filing date: 2014-06-23
Publication date: 2014-09-03

Abstract

The invention discloses a pharmaceutical composition for relieving malaise after chemoradiotherapy and a preparation method thereof. The traditional Chinese medicine composition comprises the following medicinal materials: codonopsis pilosula, astragalus membranaceus, Chinese yam, liquorice, Chinese-dates, acanthopanax, sea-buckthorn, human placenta, thellung pimpinella herb, arillus longan, lily, radix ophiopogonis, mulberry, light wheat, schisandra chinensis, lotus seed, poria with hostood, valerian, vine of multiflower knotweed, gynostemma pentaphylla, lucid ganoderma, vicia sativa and cortex albiziae. The pharmaceutical composition disclosed by the invention has the beneficial effects that the pharmaceutical composition is used for benefiting vital energy and nourishing the heart as primary functions, and tonifying the stomach and spleen and sterilizing and detoxifying as auxiliary functions by using the theory of the traditional Chinese medicine in China, the immune system of the organism can be improved, the myocardial function is protected, the gastrointestinal reaction is reduced, the renal toxicity is reduced, the liver is protected, the pathogenic factor resisting abilities, of disinfecting, sterilizing and the like, of the body are improved, and the pharmaceutical composition has the effects of being good in effect, quick to take effect, high in safety and free of toxic and side effects in the aspect of relieving malaise after chemoradiotherapy.

Description

For alleviating pharmaceutical composition of malaise after chemicotherapy and preparation method thereof

Technical field

The present invention relates to pharmaceutical technology, relate in particular to a kind of for alleviating pharmaceutical composition and the preparation method of malaise after chemicotherapy.

Background technology

The i.e. chemistry birth of chemicotherapy treatment is that the medicine that is able to disease due to pathogenic microorganism, parasite, malignant tumor is promoted treatment.Chemotherapy also refers to start drug application treatment cancer, and these special medicines can killing off tumor cells, is sometimes referred to as cell toxicity medicament.

Chemotherapy refers to the Drug therapy to pathogenic microorganism, parasite, malignant tumor associated diseases.Chemotherapy is to treat disease by chemical substance.Chemotherapy is a kind of therapeutic modality that utilizes chemicals to kill the growth and breeding of tumor cell, inhibition tumor cell and promote the differentiation of tumor cell, it is that a kind of systemic treatment means all have therapeutical effect to primary tumor, metastasis and subclinical metastasis, but chemotherapeutic treatment tumor is in killing tumor cell, also normal cell and immunity (opposing) cell are together killed, so chemotherapy is the Therapeutic Method of a kind of " destruction of all people good and bad alike ".Chemotherapy gives the conventional course for the treatment of, and can have the intermission course for the treatment of, so that normal cell is restored.Intermission is 1 week or several weeks, depends on the type of medicine or the application of medicine.The course for the treatment of, quantity depended on treatment type and therapeutic purposes (curing or control cancer).

Tumour radiotherapy is to utilize lonizing radiation as a kind of method of the treatment malignant tumor such as x ray, electric wire, proton beam and other particle beam of α, β, gamma-rays and all kinds of x roentgenotherapia machine of radiosiotope generation or accelerator generation.Radiotherapy has experienced the developing history in century more than. after roentgen finds that x-ray, Madame Curie find radium, be respectively used to soon clinical treatment malignant tumor, until radiotherapy is still the important local therapeutic approaches of malignant tumor at present.About 70% cancer patient needs with radiotherapy in the process for the treatment of cancer, approximately has 40% cancer to effect a radical cure with radiotherapy.Effect and the status of radiotherapy in oncotherapy becomes increasingly conspicuous.Radiotherapy has become one of Main Means for the treatment of malignant tumor.X-ray therapy only has the history of decades, but development is very fast.Due to the use of supertension therapy apparatus, the improvement of aid and the accumulation of experience, therapeutic effect is significantly improved, and has become one of most important means in treatment of cancer at present.China approximately has more than 70% cancer need use radiotherapy, and U.S.'s statistics also has more than 50% cancer need use radiotherapy.Radiotherapy almost can be used for all treatments of cancer, and for many cancer patients, radiotherapy is the Therapeutic Method of unique necessary use.

Although after the alone radiotherapy of the thousands of people of Biotherapeutics or also use radiotherapy, operative treatment, chemotherapy and Biotherapeutics, the cancer of having cured them.Doctor, before patient's operation, can carry out shrinkage tumor with radiotherapy, makes it to be easy to excision; After operation, with radiotherapy, suppress the growth of remaining cancerous cell.But chemicotherapy also can kill normal cell when killing cancerous cell, can also damage patient's immune system, cause immunodeficiency or decline.Immune function is as the test of E-rosette, CH50, C3 complement, T cell subsets, NK cytoactive, interleukin II ... Deng, all can be to some extent compared with declining before chemotherapy after chemotherapy.Most of antineoplastic chemotherapy medicine has immunosuppressive action, also can occur gastrointestinal dysfunction, bone marrow depression, whole body fatigue and weak, lethargy, cold perspiration, drowsiness etc. side effect, greatly reduces patient's life quality.

Chinese medicine thinks, after chemicotherapy, malaise belongs to a kind of clinical manifestation of motherland's medical science " asthenia " category.Asthenia is common a kind of disease, shows clinically the symptom that one physiological function goes down or lacks of proper care.Asthenia claims again deficient, owing to natural endowment weakness, the day after tomorrow losing the many reasons such as foster and Exogenous and internal injuries, cause, with function decline, negative and positive of qi and blood loss, with the passing of time be not main pathogenesis again, the general name of the multiple chronic weak disease that the five internal organs deficiency syndrome of take are main clinical manifestation.< < Plain Questions, leads to and comments deficiency and excess opinion > > said " lack of vital essence resulting in deficiency syndrome " to can be considered the outline of deficiency syndrome.Many reasons all can cause asthenia.The empty unit of < < reason mirror deficient syndrome have six because of > > said " have congenital because of; have the day after tomorrow because of; have varioliform exanthema and after being ill because of; have diseases caused by exogenous pathogenic factor because of; have circumstances because of; have medicine because of ", to causing the comprehensively conclusion of contrasting of the reason of asthenia.Different types of etiopathogenises acts on human body, causes the virtual loss of internal organs negative and positive of qi and blood, with the passing of time becomes again asthenia.Serious disease prolonged illness, loses after conditioning serious disease, and pathogen is crossed Sheng, visceral-qi damage, and healthy energy is difficult to recover in short-term, with the passing of time forms asthenia.Prolonged illness forms asthenia person, with the difference of disease character, the negative and positive of qi and blood of loss human body emphasizes particularly on different fields.As calentura with the passing of time, consume impairment of YIN blood; With the passing of time cold disease, is felt frustrated and is damaged sun; With the passing of time, fresh blood is not raw for blood stasis; Or lose after being ill in conditioning, healthy energy is difficult multiple, all can develop into asthenia.The various causes of disease, or cause a disease because of void, due to illness become labor, or due to illness cause void, and prolonged deficiency is not answered into labor, and its characteristic of disease, are mainly the deficient of gas, blood, yin, yang.Disease damage position is mainly at the five internal organs, especially dirty even more important with spleen kidney two.Cause the deficient cause of disease, often first cause the loss of a certain visceral-qi, blood, yin, yang, and because the five internal organs are relevant, QI and blood homology, interdependence between yin and yang, thus in the pathological process of asthenia, often interact, a dirty disease that is subject to, involve him dirty, the deficiency of vital energy can not hemopoietic, and blood deficiency is difficult anger; Deficiency of vital energy person, with the passing of time also degradation of sun; Blood deficiency person, with the passing of time the moon is also not enough; With the passing of time sun damages, and involves Yu Yin; With the passing of time the deficiency of YIN, involves in sun.So that patient's condition day by day develops, and the state of an illness is tending towards complicated.The function of take asthenia goes down, weakness, not enough syndrome due to negative and positive of qi and blood loss be its feature, on the basis of asthenia common characteristic, because the difference of deficient character has gas, blood, deficient the dividing of yin, yang.Deficiency of vital energy damage person main manifestations is shallow complexion, physical fatigue and lassitude of spirit, lazy speech low voice, spontaneous perspiration, thready pulse; Blood deficiency damage person main manifestations is lustreless complexion, the lips and nails being pale, dizziness and blurred vision, thready pulse; Deficiency of YIN damage person main manifestations is that dry mouth and tougue, dysphoria with feverish sensation in the chest palms and soles, night sweat, red tongue tongue are few, thready and rapid pulse; Yang deficiency damage person main manifestations is that pale complexion, coldness of the body with chills, pale tongue are fat that tooth prints, deep-thready pulse.

The body malaise that doctor trained in Western medicine control chemicotherapy causes there is no specially good effect scheme, it is mainly selenium supplement, reasonably combined meals, should select food nutritious and that be easy to digest, as soft meal, gruel, bread, steamed bread, steamed bun, the flesh of fish, egg, Carnis Gallus domesticus, Baoshang, Rhizoma Solani tuber osi, Fructus Musae, fruit jam, Ai Kekang etc., but do not reach desirable clinical efficacy, even to patient, cause certain psychological burden, stress, greatly reduce patient's quality of life etc.Be badly in need of clinically a kind of malaise after chemicotherapy that not only can prevent, can also improve immunity of organisms, promote the recovery of body health, the new drug that toxic and side effects is low and untoward reaction is little.

Yet the malaise that Chinese medicine prevention a variety of causes causes has abundant clinical experience and theoretical basis.< < Required Readings for Medical Professionals asthenia > >: " madam's void, does not belong to gas, belongs to blood, the vital organs of the human body, can be not outward here.And solely lift spleen kidney person, the source that water is all things on earth, soil is the mother of all things on earth, two dirty peaces and, all control all over the body, hundred diseases are raw." employing natural Chinese medicines material, toxic and side effects is low, and untoward reaction is little; on the basis of Overall View, carry out determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, treating the same disease with different methods, treating different diseases with the same therapeutic principle; malaise after control chemicotherapy, not only can improve body immune system, QI invigorating and blood producing; protection myocardial function, blood circulation promoting, the hemocytees such as the leukocyte reducing to raise, platelet; can also reduce gastrointestinal reaction; reduce nephrotoxicity, the liver protecting, raising body disinfection etc. is resisted the ability of pathogenic factor.

Summary of the invention

Technical problem to be solved by this invention is; provide a kind of for alleviating pharmaceutical composition of malaise after chemicotherapy and preparation method thereof; this pharmaceutical composition be take Qi-benefiting and heart-nourishing as main; can improve body immune system, protection myocardial function, reduces gastrointestinal reaction; reduce nephrotoxicity; the liver protecting, improves the ability that body sterilizing lamp is resisted pathogenic factor, after alleviating chemicotherapy, aspect malaise, has effect effective, rapid-action, safe and that have no side effect.

In order to solve the problems of the technologies described above, the invention provides a kind of pharmaceutical composition of alleviating malaise after chemicotherapy, wherein, comprise following raw medicinal material: Radix Codonopsis, the Radix Astragali, Rhizoma Dioscoreae, Radix Glycyrrhizae, Fructus Jujubae, Radix Et Caulis Acanthopanacis Senticosi, Fructus Hippophae, Placenta Hominis, Herba Pimpinellae thellungianae, Arillus Longan, Bulbus Lilii, Radix Ophiopogonis, Fructus Mori, Fructus Tritici Levis, Fructus Schisandrae Chinensis, Semen Nelumbinis, Poria cum Radix Pini, Rhizoma et radix valerianae, Caulis Polygoni Multiflori, Herb Gynostemmae Pentaphylli, Ganoderma, Herba Viviae Sativae and Cortex Albiziae.

In described pharmaceutical composition, the parts by weight of each raw medicinal material are preferably: Radix Codonopsis 15-30 weight portion, Radix Astragali 15-30 weight portion, Rhizoma Dioscoreae 10-20 weight portion, Radix Glycyrrhizae 10-20 weight portion, Fructus Jujubae 15-25 weight portion, Radix Et Caulis Acanthopanacis Senticosi 15-25 weight portion, Fructus Hippophae 10-20 weight portion, Placenta Hominis 5-10 weight portion, Herba Pimpinellae thellungianae 10-20 weight portion, Arillus Longan 5-10 weight portion, Bulbus Lilii 15-25 weight portion, Radix Ophiopogonis 15-20 weight portion, Fructus Mori 10-20 weight portion, Fructus Tritici Levis 10-20 weight portion, Fructus Schisandrae Chinensis 15-20 weight portion, Semen Nelumbinis 10-20 weight portion, Poria cum Radix Pini 10-20 weight portion, Rhizoma et radix valerianae 10-20 weight portion, Caulis Polygoni Multiflori 10-20 weight portion, Herb Gynostemmae Pentaphylli 10-20 weight portion, Ganoderma 15-30 weight portion, Herba Viviae Sativae 15-25 weight portion and Cortex Albiziae 5-15 weight portion.

In described pharmaceutical composition, the parts by weight of each raw medicinal material can also be preferably: Radix Codonopsis 23 weight portions, the Radix Astragali 22 weight portions, Rhizoma Dioscoreae 15 weight portions, Radix Glycyrrhizae 15 weight portions, Fructus Jujubae 21 weight portions, Radix Et Caulis Acanthopanacis Senticosi 20 weight portions, Fructus Hippophae 15 weight portions, Placenta Hominis 7 weight portions, Herba Pimpinellae thellungianae 15 weight portions, Arillus Longan 8 weight portions, Bulbus Lilii 21 weight portions, Radix Ophiopogonis 17 weight portion, Fructus Mori 15 weight portions, Fructus Tritici Levis 15 weight portions, Fructus Schisandrae Chinensis 17 weight portions, Semen Nelumbinis 15 weight portions, Poria cum Radix Pini's 15 weight portions, Rhizoma et radix valerianae 15 weight portions, Caulis Polygoni Multiflori 15 weight portions, Herb Gynostemmae Pentaphylli 15 weight portions, Ganoderma 23 weight portions, Herba Viviae Sativae 21 weight portions and Cortex Albiziae 11 weight portions.

Described pharmaceutical composition also comprises: Radix et Caulis Opuntiae Dillenii, Herba Menthae, Rhizoma Atractylodis, Pericarpium Citri Reticulatae, Rhizoma Coptidis and Polyalthia nemoralis A. D C..

In described pharmaceutical composition, the parts by weight of each raw medicinal material can be preferably again: Radix Codonopsis 15-25 weight portion, Radix Astragali 15-25 weight portion, Rhizoma Dioscoreae 15-25 weight portion, Radix Glycyrrhizae 10-20 weight portion, Fructus Jujubae 15-25 weight portion, Radix Et Caulis Acanthopanacis Senticosi 15-25 weight portion, Fructus Hippophae 10-20 weight portion, Placenta Hominis 10-15 weight portion, Herba Pimpinellae thellungianae 10-20 weight portion, Arillus Longan 5-10 weight portion, Bulbus Lilii 15-25 weight portion, Radix Ophiopogonis 15-20 weight portion, Fructus Mori 10-20 weight portion, Fructus Tritici Levis 10-20 weight portion, Fructus Schisandrae Chinensis 15-20 weight portion, Semen Nelumbinis 10-20 weight portion, Poria cum Radix Pini 10-20 weight portion, Rhizoma et radix valerianae 10-20 weight portion, Caulis Polygoni Multiflori 10-20 weight portion, Herb Gynostemmae Pentaphylli 10-20 weight portion, Ganoderma 15-30 weight portion, Herba Viviae Sativae 15-25 weight portion, Cortex Albiziae 8-15 weight portion, Radix et Caulis Opuntiae Dillenii 10-20 weight portion, Herba Menthae 10-15 weight portion, Rhizoma Atractylodis 10-20 weight portion, Pericarpium Citri Reticulatae 10-20 weight portion, Rhizoma Coptidis 15-25 weight portion and Polyalthia nemoralis A. D C. 10-20 weight portion.

In described pharmaceutical composition, the parts by weight of each raw medicinal material can also be preferably: Radix Codonopsis 21 weight portions, the Radix Astragali 19 weight portions, Rhizoma Dioscoreae 19 weight portions, Radix Glycyrrhizae 14 weight portions, Fructus Jujubae 21 weight portions, Radix Et Caulis Acanthopanacis Senticosi 20 weight portions, Fructus Hippophae 14 weight portions, Placenta Hominis 12 weight portions, Herba Pimpinellae thellungianae 15 weight portions, Arillus Longan 7 weight portions, Bulbus Lilii 20 weight portions, Radix Ophiopogonis 17 weight portion, Fructus Mori 16 weight portions, Fructus Tritici Levis 16 weight portions, Fructus Schisandrae Chinensis 17 weight portions, Semen Nelumbinis 15 weight portions, Poria cum Radix Pini's 15 weight portions, Rhizoma et radix valerianae 14 weight portions, Caulis Polygoni Multiflori 14 weight portions, Herb Gynostemmae Pentaphylli 14 weight portions, Ganoderma 25 weight portions, Herba Viviae Sativae 21 weight portions, Cortex Albiziae 10 weight portions, Radix et Caulis Opuntiae Dillenii 15 weight portions, Herba Menthae 13 weight portions, Rhizoma Atractylodis 15 weight portions, Pericarpium Citri Reticulatae 17 weight portions, Rhizoma Coptidis 22 weight portions and Polyalthia nemoralis A. D C. 15 weight portions.

In order better to realize foregoing invention object, the invention provides that a kind of the dosage form of described pharmaceutical composition is capsule for alleviating the preparation method of the pharmaceutical composition of malaise after chemicotherapy, described preparation method comprises the following steps:

Step a, cross 120 order dusting covers after described raw medicinal material is put into pulverizer and pulverized, the fine powder amount that enable pass is crossed 120 mesh sieves is reaching 30%～40%, collects by the raw material fine powder of 120 mesh sieves standby;

Step b, remaining particulate matter after sieving in step a is put into the ethanol heating and refluxing extraction 2 times that ratio of weight and number is 5～7 times of amounts, each 1～2 hour, 2 extracting solution are merged standing;

Step c, the medicinal residues that in step b, ethanol extraction is crossed are added to ratio of weight and number is 5～7 times of water gaging heating and refluxing extraction 2 times, each 1～2 hour, 2 extracting solution is merged standing;

Steps d, above-mentioned two kinds of extracting solution are merged, the filtrate of 1.38 o'clock when concentrating under reduced pressure relative density is 50 ℃～60 ℃, reclaims ethanol, and gained filtrate is adjusted to proportion to 1.06, pass into spray dryer and spray dryly, the compressed air pressure of crossing spray dryer shower nozzle is 4kg/m ², hothouse hot stream temperature is 100 ℃, obtains raw material medicated powder; The raw material fine powder obtaining after sieving is mixed and incapsulated with raw material medicated powder.

The dosage form of described pharmaceutical composition is oral liquid, and described preparation method comprises the following steps:

The first step, Placenta Hominis, Herba Pimpinellae thellungianae, Arillus Longan, Bulbus Lilii, Radix Ophiopogonis, Fructus Mori, Fructus Tritici Levis and Fructus Schisandrae Chinensis are mixed, the alcohol reflux that to add with respect to 5～8 times, mixture amount determining alcohols be 90%～95% 2～4 times, each 3～4 hours, filter respectively, each time filtrate merges, and reclaims ethanol, be concentrated into the mastic that 70 ℃ of relative densities are 1.36～1.38, standby;

Second step, is mixed in proportion surplus stock medical material, adds with respect to 5～8 times of water gagings of mixture, boils 3～6 hours, filters, and is concentrated into the mastic that 70 ℃ of relative densities are 1.32～1.34;

The 3rd step, the described mastic that the first step, second step are obtained mixes, and 70 ℃～80 ℃ reduced vacuum are dry, and powder gets dry extract;

The 4th step, will the 3rd add ethanol in the described dried cream powder that obtains of step, obtain containing alcohol mastic, and described is 65%～70% containing alcohol mastic containing alcohol amount; By described, containing alcohol mastic, carry out successively cold preservation processing, precipitation process, filtration treatment, recovery Ethanol Treatment, obtain dealcoholysis mastic, wherein, the cold preservation processing time is 24～48 hours, and refrigerated storage temperature is 3 ℃～6 ℃;

The 5th step, will add cane sugar powder, active carbon in described dealcoholysis mastic, carries out successively heat treated, filtration treatment, dilution process, obtains semi-finished product; The weight ratio of described dealcoholysis mastic and described cane sugar powder is 1: 0.2～0.35; The weight ratio of described dealcoholysis mastic and described active carbon is 1: 0.003～0.005; The time of described heat treated is 60～90 minutes, and temperature is 150 ℃～180 ℃;

The 6th step, the more described semi-finished product of the 5th step acquisition are carried out to filtration treatment, embedding processing, sterilization treatment successively, obtain described Chinese medicine preparation oral liquid finished product.

The dosage form of described pharmaceutical composition is tablet, and described preparation method comprises the following steps:

The first step, is mixed in proportion described each raw medicinal material, adds the ethanol that the determining alcohol with respect to 4～5 times of mixture qualities is 85%～90%, and reflux 2～4 hours is extracted, and filters and obtains the first extracting solution; The medicinal residues that filter to obtain add the ethanol that the determining alcohol with respect to 2～3 times of described medicinal residues quality is 90%～95% again, and reflux 1～3 hour, extracts, and filters and obtains the second extracting solution; The first extracting solution and the second extracting solution are merged, and concentrating under reduced pressure is removed alcohol solvent, dry, obtains and gets dry extract;

Second step, the dry cream that the first step is obtained is placed in super micron mill to be pulverized 2～3 hours, pulverizes, and sieves, and obtains 300 order～400 object micropowders;

The 3rd step, the micropowders that second step is obtained, add microcrystalline Cellulose with respect to 0.1～0.3 times of its quality, 0.15～0.3 times of lactose, the starch of 0.2～0.35 times, sieve, mix homogeneously, granulate, dry, add with respect to 0.025～0.04 times of magnesium stearate of micropowders quality, granulate, tabletting, makes.

The invention has the beneficial effects as follows: pharmaceutical composition of the present invention; utilize the traditional theory of Chinese medical science of China; pharmaceutical composition be take Qi-benefiting and heart-nourishing as main, take stomach invigorating spleen reinforcing, disinfecting detoxifying as auxiliary, can improve body immune system; protection myocardial function; reduce gastrointestinal reaction, reduce nephrotoxicity, the liver protecting; improve the ability that body sterilizing lamp is resisted pathogenic factor, after alleviating chemicotherapy, aspect malaise, there is effect effective, rapid-action, safe and that have no side effect.

The specific embodiment

Chinese medicine thinks, after chemicotherapy, malaise belongs to a kind of clinical manifestation of motherland's medical science " asthenia " category.Asthenia is common a kind of disease, shows clinically the symptom that one physiological function goes down or lacks of proper care.Asthenia claims again deficient, owing to natural endowment weakness, the day after tomorrow losing the many reasons such as foster and Exogenous and internal injuries, cause, with function decline, negative and positive of qi and blood loss, with the passing of time be not main pathogenesis again, the general name of the multiple chronic weak disease that the five internal organs deficiency syndrome of take are main clinical manifestation.< < Plain Questions, leads to and comments deficiency and excess opinion > > said " lack of vital essence resulting in deficiency syndrome " to can be considered the outline of deficiency syndrome.Many reasons all can cause asthenia.The empty unit of < < reason mirror deficient syndrome have six because of > > said " have congenital because of; have the day after tomorrow because of; have varioliform exanthema and after being ill because of; have diseases caused by exogenous pathogenic factor because of; have circumstances because of; have medicine because of ", to causing the comprehensively conclusion of contrasting of the reason of asthenia.Different types of etiopathogenises acts on human body, causes the virtual loss of internal organs negative and positive of qi and blood, with the passing of time becomes again asthenia.Serious disease prolonged illness, loses after conditioning serious disease, and pathogen is crossed Sheng, visceral-qi damage, and healthy energy is difficult to recover in short-term, with the passing of time forms asthenia.Prolonged illness forms asthenia person, with the difference of disease character, the negative and positive of qi and blood of loss human body emphasizes particularly on different fields.As calentura with the passing of time, consume impairment of YIN blood; With the passing of time cold disease, is felt frustrated and is damaged sun; With the passing of time, fresh blood is not raw for blood stasis; Or lose after being ill in conditioning, healthy energy is difficult multiple, all can develop into asthenia.

The various causes of disease, or cause a disease because of void, due to illness become labor, or due to illness cause void, and prolonged deficiency is not answered into labor, and its characteristic of disease, are mainly the deficient of gas, blood, yin, yang.Disease damage position is mainly at the five internal organs, especially dirty even more important with spleen kidney two.Cause the deficient cause of disease, often first cause the loss of a certain visceral-qi, blood, yin, yang, and because the five internal organs are relevant, QI and blood homology, interdependence between yin and yang, thus in the pathological process of asthenia, often interact, a dirty disease that is subject to, involve him dirty, the deficiency of vital energy can not hemopoietic, and blood deficiency is difficult anger; Deficiency of vital energy person, with the passing of time also degradation of sun; Blood deficiency person, with the passing of time the moon is also not enough; With the passing of time sun damages, and involves Yu Yin; With the passing of time the deficiency of YIN, involves in sun.So that patient's condition day by day develops, and the state of an illness is tending towards complicated.The function of take asthenia goes down, weakness, not enough syndrome due to negative and positive of qi and blood loss be its feature, on the basis of asthenia common characteristic, because the difference of deficient character has gas, blood, deficient the dividing of yin, yang.Deficiency of vital energy damage person main manifestations is shallow complexion, physical fatigue and lassitude of spirit, lazy speech low voice, spontaneous perspiration, thready pulse; Blood deficiency damage person main manifestations is lustreless complexion, the lips and nails being pale, dizziness and blurred vision, thready pulse; Deficiency of YIN damage person main manifestations is that dry mouth and tougue, dysphoria with feverish sensation in the chest palms and soles, night sweat, red tongue tongue are few, thready and rapid pulse; Yang deficiency damage person main manifestations is that pale complexion, coldness of the body with chills, pale tongue are fat that tooth prints, deep-thready pulse.

Pharmaceutical composition of the present invention adopts natural Chinese medicines material, and toxic and side effects is low, and untoward reaction is little; on the basis of Overall View, carry out determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, treating the same disease with different methods, treating different diseases with the same therapeutic principle; malaise after control chemicotherapy, not only can improve body immune system, QI invigorating and blood producing; protection myocardial function, blood circulation promoting, the hemocytees such as the leukocyte reducing to raise, platelet; can also reduce gastrointestinal reaction; reduce nephrotoxicity, the liver protecting, raising body disinfection etc. is resisted the ability of pathogenic factor.It comprises following raw medicinal material: Radix Codonopsis, the Radix Astragali, Rhizoma Dioscoreae, Radix Glycyrrhizae, Fructus Jujubae, Radix Et Caulis Acanthopanacis Senticosi, Fructus Hippophae, Placenta Hominis, Herba Pimpinellae thellungianae, Arillus Longan, Bulbus Lilii, Radix Ophiopogonis, Fructus Mori, Fructus Tritici Levis, Fructus Schisandrae Chinensis, Semen Nelumbinis, Poria cum Radix Pini, Rhizoma et radix valerianae, Caulis Polygoni Multiflori, Herb Gynostemmae Pentaphylli, Ganoderma, Herba Viviae Sativae and Cortex Albiziae; Preferably, also comprise Radix et Caulis Opuntiae Dillenii, Herba Menthae, Rhizoma Atractylodis, Pericarpium Citri Reticulatae, Rhizoma Coptidis and Polyalthia nemoralis A. D C..Wherein, Radix Codonopsis, the Radix Astragali, Rhizoma Dioscoreae, Radix Glycyrrhizae, Fructus Jujubae, Radix Et Caulis Acanthopanacis Senticosi, Fructus Hippophae, Ganoderma benefiting QI and nourishing blood, spleen-benefiting mind-tranquilizing; Placenta Hominis, Herba Pimpinellae thellungianae, Arillus Longan, Bulbus Lilii, Radix Ophiopogonis, Fructus Mori, Herba Viviae Sativae can YIN nourishing, nourish blood, reinforcing the heart; Fructus Tritici Levis, Fructus Schisandrae Chinensis, Semen Nelumbinis, Poria cum Radix Pini, Rhizoma et radix valerianae, Caulis Polygoni Multiflori, Cortex Albiziae nourishing blood and promoting blood circulation, tranquilizing by nourishing the heart; Rhizoma Atractylodis, Pericarpium Citri Reticulatae and Polyalthia nemoralis A. D C. compatibility stomach invigorating spleen reinforcing; Herb Gynostemmae Pentaphylli, Radix et Caulis Opuntiae Dillenii, Herba Menthae, coptis detoxifcation sterilization; Full side's compatibility is rigorous, not only can improve the hemocytees such as body immune system, leukocyte increasing, platelet; all right QI invigorating and blood producing, protection myocardial function, reduces gastrointestinal reaction; reduce nephrotoxicity, the liver protecting, raising body disinfection etc. is resisted the ability of pathogenic factor etc.

Wherein, the pharmacological property of above-mentioned raw materials medical material is as follows:

Radix Codonopsis: property is flat, sweet in the mouth, micro-acid; Return spleen, lung meridian.Invigorating the spleen and replenishing QI, spleen invigorating lung benefiting.For deficiency of the spleen and lung, the cardiopalmus of breathing hard, anorexia and loose stool, dyspnea due to deficiency cough, interior-heat is quenched one's thirst.These product are clinical conventional Qi-tonifying drug, function invigorating the spleen to benefit the lung, effect person of modern times ginseng and for a little less than, be applicable to various deficiency of vital energy deficiency persons.Contained saponin, inulin, Alkaloid, starch etc. have strong effect in various degree to the many internal organs of human body, can improve the adaptability of human body.There is antiulcer, can increase intestinal tension force, regulate stomach motion, in the intestines and stomach coordinating preparation, reuse the intestines and stomach regulation of mental activities agent of Radix Codonopsis to chronic diarrhea, ulcerative colitis, antral gastritis, chronic atrophic gastritis etc. quite have effect.

The Radix Astragali: sweet, tepor; Return lung, spleen, liver, kidney channel.< < Bencao Beiyao > >: " lossless can sending out, has antiperspirant to stop for the Radix Astragali, life consolidating superficial resistance; Process with invigorating middle warmer beneficial vigour, strong taste.Hemopoietic, granulation promoting, evacuation of pus expelling the toxic substance from the body with tonic, carbuncle sore panacea.Variola does not rise, and yang deficiency should it without hot person." the just > > of < < book on Chinese herbal medicine: " and the Radix Astragali, soil in tonification, replenishing vital QI with drugs of warm nature taste, all middle gas is depressed, and spleen soil is weak, and sagging person is the most suitable for clearing heat in QI system.The through people's of its skin skin table muscle, solid protection is defended sun, enriches table minute, is its speciality, thus all diseases of exterior deficiency, the most refreshing agent." function consolidating superficial resistance arresting sweating, inducing diuresis to remove edema, the evacuation of pus of holder skin ulcer, regulating fluid apssage.The Radix Astragali strengthens heart contraction ability, can improve the blood circulation of whole body, can coronary artery dilator, kidney blood vessel and Rhizoma Bistortae peripheral vessel, make cutaneous circulation vigorous; Can improve the nonspecific immunity power of body, protect the liver and fall hypoglycemic effect, staphylococcus, blood dissolubility streptococcus, Diplococcus pneumoniae, dysentery bacterium etc. are had to inhibitory action.The Radix Astragali can appreciable impact splenocyte Information Conduction, realizes immunoregulation effect.Can be used for hypertension, ischemic heart desease, acute glomerulonephritis, gastric ulcer, psoriasis, diabetes, osteoporosis.

Rhizoma Dioscoreae: sweet in the mouth, property is put down, enter lung, spleen, kidney channel, there is strengthening the spleen and tonifying the lung, stomach reinforcing the kidney invigorating, the benefit of reinforcing the kidney essence, hearing-improing and eyesight improving, help that the five internal organs, bone and muscle strengthening, long will are calmed the nerves, the effect of life lengthening, cure mainly that weakness of the spleen and stomach, lassitude, inappetence, chronic diarrhea and dysentery, insufficiency of lung-QI are dry, phlegm dyspnea cough, kidney qi loss, soreness of the waist and knees, lower limb flaccidity are weak, the red card such as swollen, fat of the frequent micturition of quenching one's thirst, the premature ejaculation of passing out semen, leukorrhagia nebulousurine, skin.Rhizoma Dioscoreae (parched with bran) spleen reinforcing stomach invigorating.For insufficiency of the spleen lack of appetite, the loose stool of having loose bowels, leukorrhagia.

Radix Glycyrrhizae: nature and flavor are sweet, flat.Enter spleen, stomach, lung meridian.< < herbal classic > > says: " main the five internal organs six mansion cold and heat pathogens, hard muscles and bones, longue meat, times power, incised wound is swollen, removing toxic substances ".Cloudy (no) < < of people property of medicine opinion > > says: " cold type of pain in main abdomen, controls infantile convulsion, except distention and fullness in the abdomen; Tonification the five internal organs; Make all poison of drug; Support kidney qi internal injury, make flaccidity; Housewife's human blood drop lumbago; Void and frequent fever; Add and with it ".Can QI invigorating invigorating middle warmer, relieving spasm to stop pain, nourishing the lung to arrest cough, eliminating fire and detoxication, coordinating the actions of various ingredients in a prescription.Main asthenia lack of appetite, leanness yellowish complexion, shortness of breath and palpitation, stomachache loose stool, the anxious pain of extremity contraction, hysteria, cough and asthma, laryngopharynx swelling and pain, carbuncle skin ulcer swells and ache, infantile carbuncle, and medicine, alimentary toxicosis.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, the anxious pain of extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.Western modern medicine haircut is existing, and Radix Glycyrrhizae agent has the function of antiinflammatory and the reflection of resistance state, therefore in doctor trained in Western medicine clinically mainly as demulcent.Relieving cough, eliminates the phlegm, treatment pharyngalgia laryngitis; Radix Glycyrrhizae or enoxolone have the effect of desoxycortone class, and chronic adrenocortical hypofunction is had to good efficacy; Glycyrrhiza preparation can promote stomach mucus to form and secretion, extends the epithelial cell life-span, has anti-inflammatory activity, is usually used in the treatment of chronic ulcer and duodenal ulcer; The flavone of Radix Glycyrrhizae has antiinflammatory, spasmolytic and antiacid effect; Radix Glycyrrhizae is also one of primary raw material of rendan mini-pills.

Fructus Jujubae: sweet in the mouth, warm in nature, enter spleen, stomach warp.There is the effect of air making-up and spleen enlivening, nourishing blood to tranquillize the mind, harmonizing yingfen and weifen, the mitigation property of medicine, for weakness of the spleen and stomach, fatigue and asthenia, anorexia and loose stool, insufficiency of vital energy and blood, has a headache and fever, the cards such as sweating hot blast, Fructus Jujubae has the effect of muscle strength reinforcing, has the total serum protein of increasing and albuminous function.The cyclic adenosine monophosphate that Fructus Jujubae is contained, is the essential composition of human body cell energy metabolism, can muscle strength reinforcing, allaying tiredness, blood vessel dilating, increase myocardial contraction, improve myocardial nutrition, control cardiovascular system diseases is had to good effect; Fructus Jujubae has good therapeutic effect to diseases such as chronic hepatitis, liver cirrhosis, anemia, anaphylactoid purpura; Fructus Jujubae contains triterpenoid compound and cyclic adenosine monophosphate, has stronger anticancer, anti-allergic effects.Fructus Jujubae can moisten cardiopulmonary, cough-relieving, tonifying five ZANG-organs, it is deficient to control, except the intestines and stomach addiction gas, can also regulating the spleen and stomach support spleen, flat gastric qi, logical nine orifices, help 12 through etc.

Radix Et Caulis Acanthopanacis Senticosi: acrid in the mouth, hardship, micro-sweet, warm in nature, enter spleen, kidney, heart channel, there is replenishing QI to invigorate the spleen, tonifying the kidney for tranquilization, the effect of expelling wind and removing dampness, soft for anemofrigid-damp arthralgia, lumbocrural pain, muscles and bones flaccidity, be slow in action, a little less than body weakness with emaciation, traumatic injury, fracture, edema, beriberi, the uncontrolled urination card such as itch.The sweet A of Radix Et Caulis Acanthopanacis Senticosi is also containing this constituents in carotene ， Ren Ginseng.In human body, the excretion of cholesterol can be promoted, Blood Cholesterol too high levels disease can be prevented and treated.The sweet B of Radix Et Caulis Acanthopanacis Senticosi is Syringa oblata Lindl. element (Syringin), is the main strong composition of Radix Et Caulis Acanthopanacis Senticosi, has short gonad, radioprotective, fatigue-resisting function, has the physiologically active similar to Ren Ginseng Saponin.Radix Et Caulis Acanthopanacis Senticosi is containing super oxidation disproportionation ferment SOD (Superoxide dimutase) complex, SOD has good anti-oxidation function, can strengthen the effect that human immunity and opposing free radical are attacked, there is antioxidation, can strengthen body immunity, prevent aging and promotion health.

Fructus Hippophae: Fructus Hippophae and oil have very high medical value, can reduce cholesterol, allevating angina pectoris outbreak, prevents and treats the effect of coronary atherosclerotic heart disease in addition; Have and eliminate the phlegm, cough-relieving, relieving asthma and treat the effect of chronic tracheitis; Can treat gastric duodenal ulcer and dyspepsia etc., evident in efficacy to diseases such as chronic superficial gastritis, atrophic gastritis, colitis; Burn, scald, cutter burning, cold injury are had to good therapeutical effect; Cervical erosion is had to good therapeutic effect.In sea buckthorn fruit, contain 7 kinds of Endospermum chinense Benth. materials such as isorhamnetin and glucoside thereof, Quercetin, nimbecetin, the usefulness that has cough-relieving, relievings asthma and eliminate the phlegm, expand coronary vasodilator, reduce cholesterol, is usually used in treating ischemic heart desease, and treatment angina pectoris effective percentage is reached to 94%.In Fructus Hippophae, SOD active component is abundant, and every gram of sea-buchthorn fresh fruit SOD content reaches 2746.0 enzyme units, and its content is 4 times of Radix Ginseng.It can block the free radical producing because of substance in vivo peroxidating, and the generation of this free radical and human senility, disease is closely related.

Placenta Hominis: sweet, salty, warm; Enter lung, the heart, kidney channel.< < Bencao Shiyi > >: " it is black that face blackens skin for main QI and blood weakness and emaciation, married woman's strain, and the interior all diseases of abdomen are thin worried person gradually." modern medicine study thinks, Placenta Hominis is containing protein, sugar, calcium, vitamin, immune factor, estrogen, gravidity assisting ketone, steroid hormone, promoting sexual gland hormone, thyroliberin etc., can promote mammary gland, uterus, vagina, the growth of testis, thyroid is also had to facilitation, the clinical uterine hypoplasia that is used for the treatment of, metratrophia, myometritis, functional menolipsis, metrorrhagia, milk deficiency etc., all there is significant curative effect, to pulmonary tuberculosis, bronchial asthma, anemias etc. also have good effect, grind oral or coloclysis into powder and can prevent measles or mitigation symptoms.Portal cirrhotic ascites and schistosomicide end-age cirrhosis ascites are also had to certain curative effect.

Herba Pimpinellae thellungianae: sweet in the mouth, pungent, warm in nature; GUIXIN, kidney, lung, spleen channel.< < Shaanxi Chinese herbal medicine > >: " cold relieving lung qi dispersing, the removing toxic substances of dispeling the wind, promoting blood circulation to remove blood stasis, reducing swelling and alleviating pain." < < bulletin of Chinese materia medica > >: " treatment puerperal asthenia, sexual impotence is sterile, anemofrigid cold, cough due to fluid-retention etc." warming spleen and stomach for dispelling cold, warming the kidney to activate YANG, blood circulation promoting and blood stasis dispelling; Invigorating the spleen and benefiting QI, tranquilizing by nourishing the heart, eliminating phlegm and stopping cough.Cure mainly Keshan disease, heart reconstruction, breathes hard, cough with asthma.For coldness and pain in the epigastrium due to Deficiency and coldness of spleen and stomach, vomit, have loose bowels etc.With controlling wind-cold affecting lung, Lung Qi obstraction, cough and expectoration, uncomfortable in chest panting.Preliminary pharmacological tests proof root and herb have anticoagulant effect.Herb still can coronary artery dilator, reduce coronary resistance, has hypotensive effect, can reduce myocardial oxygen consumption.Flavonoid glycoside can strengthen the activity of cardiac muscle and cerebral tissue respiratory enzyme; Its water decoction-alcohol sedimentation preparation has obvious hypotensive effect, and has certain strong effect.

Arillus Longan: < < the southern regions of the Yunnan Province book on Chinese herbal medicine > >: " nourishing blood to tranquillize the mind, long intelligence arresting sweating, appetizing strengthening the spleen." < < Quanzhou book on Chinese herbal medicine > >: " tonifying YANG QI invigorating, tonifying the spleen and stomach.Control married woman's puerperal edema, deficiency of vital energy edema, diarrhea due to hypofunction of the spleen.Invigorating the heart and spleen, " nourishing blood to tranquillize the mind.For insufficiency of vital energy and blood, severe palpitation, forgetful insomnia, blood deficiency and yellow complexion.The contained sugar amount of Arillus Longan is very high, is the monosaccharide of absorption easy to digest, can be directly absorbed by the body, therefore weak anemia is worn with age, and weakness due to chronic disease, often eating a little Arillus Longans is to have very much benefiting action; Women puerperal, Arillus Longan is also that food mended in important tune.Because of iron content and vitamin B2 very abundant, can alleviate uterine contraction and the sagging sense of palace body., anemia weak for women puerperal, body void etc., available Arillus Longan adds Radix Angelicae Sinensis, Fructus Lycii, several stewed chickens of Fructus Jujubae (enucleation).Or every day edible Arillus Longan boiled egg, can promoting blood flow to regulate menstruation, promote antisecosis.

Bulbus Lilii: Bulbus Lilii is except containing protein 21.29%, fat 12.43%, reducing sugar 11.47%, starch 1.61%, and calcium, phosphorus, ferrum, every hectogram are containing outside the nutrients such as 1.443 milligrams of vitamin Bs, 21.2 milligrams of vitamin Cs, also contain some special nutritional labelings, as multiple alkaloids such as colchicine.These composition comprehensive functions, in human body, not only have the merit of good nutritious tonifying, but also multiple Seasonal diseases dry in autumn and that cause is had to certain preventive and therapeutic effect.In the traditional Chinese medical science, say that fresh Bulbus Lilii has tranquilizing by nourishing the heart, the effect of nourishing the lung to arrest cough, is highly profitable to weakling after being ill.

Radix Ophiopogonis: sweet, the micro-hardship of property, is slightly cold; GUIXIN, lung, stomach warp.Have YIN nourishing and the production of body fluid promoting, the effect that lung moistening clears away heart-fire, can be used for sore throat pharyngalgia, and Tianjin wound is thirsty, and interior-heat is quenched one's thirst, vexed insomnia, dryness of the intestine constipation etc.Clear the moon of supporting lung stomach goes heart use more, the YIN nourishing use that connects with the heart that clears away heart-fire more.These product are sweet cold clear and rich, are apt to control deficiency of stomach-Yin, and dry tongue is thirsty, the indigestion and loss of appetite not hungry card that waits.In addition the available deficiency of YIN dryness of the intestine of controlling also, constipation person.Modern study shows, can improve immunologic function Radix Ophiopogonis, various bacteria is had inhibitory action, can strengthen pituitary adrenal system function, improves organism adaptation ability.Join Radix Adenophorae (Radix Glehniae) Radix Ophiopogonis, lung stomach is ruled together, and has the cool stomach of lung heat clearing, and the good effectiveness of YIN nourishing and the production of body fluid promoting is lacked expectorant, the diseases such as dry laryngopharynx for the dry cough due to lung-dryness syndrome due to deficiency of YIN or thermal burn lung yin.

Fructus Mori: sweet, sour, cold.GUIXIN, liver, kidney channel.Function cures mainly: the YIN nourishing of enriching blood, and promote the production of body fluid and moisturize.For vertigo and tinnitus, palpitation and insomnia, early whitening of beard and hair, Tianjin wound is thirsty, and interior-heat is quenched one's thirst, blood deficiency and constipation.

Fructus Tritici Levis: sweet salty, cool, GUIXIN warp.< < Compendium of Materia Medica > >: " QI invigorating heat extraction stops spontaneous sweating, hectic fever due to YIN-deficiency consumptive fever, married woman's consumptive fever." < < herbal classic meets former > >: " swimmer, can hold back night sweat, gets the heat of its loose myocutaneous junction, site where the skin and muscle are joined also." except deficiency-heat, hidroschesis.Main only fever due to yin deficiency, night sweat, spontaneous perspiration.Rich in starch, protein, fat, mineral, calcium, ferrum, thiamine, riboflavin, nicotinic acid, vitamin A and vitamin C etc.

Fructus Schisandrae Chinensis: warm in nature, sour in the mouth, sweet, returns lung, the heart, kidney channel, the < < Newly Revised Canon of Materia Medica > > such as Tang carry " the sweet acid of five tastes skin and flesh; arduous in core, has saline taste ", therefore there is the name of Fructus Schisandrae Chinensis.Ancient medical book Cheng Ta Chi Zhu, profound and, meeting and, list in the earliest Sheng Nong's herbal classic top grade, herbal function is the power of strengthening by means of tonics, medical value is high, the selenium of generally arranging in pairs or groups making nourishing the liver sheet and bifendate, Bicyclols etc., have hepatoprotective function.Fructus Schisandrae Chinensis is divided into 2 genus, i.e. Kadsura and Schizandra.These seeds are easily planted, and slightly raw, survival rate is high.There is convergence astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, the effect of kidney calming, for chronic cough dyspnea due to deficiency, emission, enuresis frequent micturition, incessant chronic diarrhea, spontaneous perspiration, night sweat, Tianjin wound is thirsty, the deficient pulse of losing heart, the card such as interior-heat is quenched one's thirst, palpitation and insomnia.Fructus Schisandrae Chinensis has antiinflammation, to prevent hepar damnification, activates anabolic process to promote impaired hepatocellular reparation, and can strengthen the activity of DNA (DNA) synthetic and ornithine decarboxylase, regeneration liver cell.

Semen Nelumbinis: hardship, cold, nontoxic.Enter the heart, lung, kidney three warps.< < feeding habits books on Chinese herbal medicine > >: " the raw end that is taken as, adjusts lower three money with rice drink, treats thirsty disease of thirst due to hemorrhage disease, puerperal." this leather of < < is new > > again: " clearing away heart-fire, suppressing the hyperactive liver fire, lung-fire, falls in purgation of spleen excess fire.The relieving restlessness of relieving summer heat, promoting the production of body fluid to quench thirst, controls order redness." < < Wenbing Tiaobian, Detailed Analysis of Epidemic Warm Diseases > >: " Plumula Nelumbinis, walks kidney by the heart, can make to lead in kidney under heart-fire, and winding rises again, can make kidney tide waterborne in the heart." for calentura, vexed coma, summer-heat excessive thirst, hypertension, dysphoria with smothery sensation insomnia.Among the people conventional with the drink of making tea, there is clearing away heart-fire, the effect of only passing out semen, the insomniac to disarmony between the heart and kidney, hyperactivity of fire caused by deficiency of YIN, food the most suitable.Well go in addition the effect of heart-fire, can treat aphtha of the mouth and tongue, and conduce to sleep.

Poria cum Radix Pini: sweet, light; GUIXIN, spleen channel.< < property of medicine opinion > >: " main infantile convulsion, tranquilizing the mind are mended tired; Main acute pain in the epigastrium is hard full, and small intestinal is unfavorable." < < medicineization justice > >: " Poria cum Radix Pini, its body is heavy, mental disorder may be cured with heavy sedatives, its benefit warm in nature, drugs with tonic function being used for the debility." function mind calming, calm the nerves, diuretic.The palpitation with fear that is used for having a guilty conscience, forgetful, insomnia, infantile convulsion, dysuria.Laboratory animal, with after Poria cum Radix Pini 10-20g/kg gavage, enters quiet sleepy state, but without sleep phenomenon; For the mice of caffeine sodium benzoate excitement, with Poria cum Radix Pini's decoct, 5g/kg makes lumbar injection, can make its calmness, and calm rate is 90%, calm index 3.11; If use 20g/kg gavage instead, calm rate is 85.7%, calm index 1.64.

Rhizoma et radix valerianae: pungent, sweet, warm; GUIXIN, Liver Channel.< < Traditional Chinese Medicine in Sichuan will > >: " control cranial nerve and the heart, stomach is weak, chronic off one's dot and urine collapse." control irritability, a little less than stomach, lumbago, menoxenia, traumatic injury.Apply its effect of calming the nerves and can be used for treating the diseases such as malaise, cardiopalmus dreaminess, can with the compatibilities such as Semen Ziziphi Spinosae, Cortex Albiziae, Caulis Polygoni Multiflori; Another and Radix Salviae Miltiorrhizae, Herba Leonuri, Herba Lycopi, the same use of Flos Carthami, can be used to treat the disease of abdominal pain in menstruation, soreness of the waist and knees, bone fracture and injury.Rhizoma et radix valerianae has quelling effect to central nervous system, when excited, can stabilize nerve, can help to refresh when fatigue.Contained Rhizoma et radix valerianae epoxy three esters of Rhizoma et radix valerianae root can help to alleviate spasm and pain, contribute to relax neuropathic dyspepsia, stomach spasm or enteritis.Total alkaloids in Rhizoma et radix valerianae has antibacterial action, especially can resist the infection that gram-positive bacterium is caused.The pink flower Rhizoma et radix valerianae of Rhizoma et radix valerianae can relieving insomnia, sleep disorder, flurried, anxiety neurosis and other imbalance diseases, also can relax one's muscles simultaneously, makes interior environment oil recover stable state.

Caulis Polygoni Multiflori: sweet in the mouth, micro-hardship, property is flat; GUIXIN, Liver Channel, having can tranquilizing by nourishing the heart, the effect of dispelling wind and removing obstruction in the collateral, cures mainly insomnia and dreamful sleep, blood deficiency general pain, rheumatic arthralgia; The cards such as skin pruritus, Caulis Polygoni Multiflori can be invigorated blood circulation, stimulated the menstrual flow, blood vessel dilating, blood circulation promoting, stimulating milk secretion detumescence.Have promotion hemopoietic function, strengthen immunologic function, blood fat reducing and atherosclerosis, protect the liver, and Radix Polygoni Multiflori contains the effective ingredient such as chrysophanol, emodin, chrysophanic acid, physcione, fatty oil, starch, saccharide, rhaponticin, lecithin.Pharmacological research proves, Radix Polygoni Multiflori can promote the conversion of human lymphoblastoid cell.Still there are the effects such as the serum cholesterol of reduction, arteriosclerosis, anti-light poison.

Herb Gynostemmae Pentaphylli: sweet in the mouth, hardship, cold nature; Return lung meridian, spleen channel, kidney channel.Energy QI invigorating, calms the nerves, blood pressure lowering, heat-clearing and toxic substances removing, eliminating phlegm and stopping cough.After small number of patients is taken medicine, there is the symptoms such as nausea and vomiting, abdominal distention diarrhoea (or constipation), dizziness, dim eyesight, tinnitus.Take after Herb Gynostemmae Pentaphylli, enterogastric peristalsis is accelerated, and it is long that appetite increases the resistance to time of hungering and thirst, and not only treats constipation but also control loose stool.Reaction excited to cerebral cortex and that suppress can keep suitable balance, and nervus centralis is had to dual regulation.There is good analgesia, sleep peacefully, antitonic effect.On the basis of reduction myocardial wall anxiety, mitigation cerebrovascular and peripheral vascular resistance, can strengthen heart and brain vigor, strengthen coronary flow, relax arteriosclerosis, impel integral body to circulate more vigorous and smooth.Experiment showed, not that diet is rich and take Herb Gynostemmae Pentaphylli group, and avoid meat and refuse to obey Herb Gynostemmae Pentaphylli group, make regular check on comparison, body inner bag is solid close with neutral fat content.Herb Gynostemmae Pentaphylli has optimum conversion regulating action to body fat mass in human body as can be seen here.Take the mouse comparison of Herb Gynostemmae Pentaphylli and disobedience, the approximately long 31-57% of its swimming time, and antisecosis is also faster, people takes after Herb Gynostemmae Pentaphylli, and physical energy is more abundant, and even indefatigability tired, be also easy to recover, thereby work efficiency increases.Human body part function is weak, can produce allergy to Cucumber, and forms the diseases such as bronchus is panted, skin rashes, arthralgia, and Herb Gynostemmae Pentaphylli is rather good to these sick effects.

Ganoderma: property is sweet, flat.GUIXIN, lung, liver, kidney channel.Cure mainly asthenia, cough, asthma, insomnia, dyspepsia, malignant tumor etc.Animal pharmacology shows experiment: Ganoderma has inhibitory action to nervous system, and blood circulation has blood pressure lowering and strengthens the effect of cardiac contractile force, and respiratory system is had to phlegm-dispelling functions, in addition, also has hepatoprotective, improves immunologic function, antibacterially waits effect.

Herba Viviae Sativae: sweet in the mouth; Pungent; Cold in nature.GUIXIN; Liver; Spleen channel; Function cures mainly: kidney tonifying; Diuretic; Hemostasis; Cough-relieving.Main lumbago due to renal deficiency; Seminal emission; Jaundice; Edema; Malaria; Epistaxis; Cardiopalmus; Cough with copious phlegm; Have through uncomfortable; Sore swollen toxin.

Cortex Albiziae: sweet, flat; Enter the heart, Liver Channel.< < Japan hanako materia medica > >: " soft extracts, subduing inflammation reuniting the fractured tendons and bones." < < Sheng Nong's herbal classic > >: " Herba Albiziae, sweet in the mouth is flat.Main settling five organs, sharp will, makes us happy carefree ... raw mountain valley." administration of antiallergic Cortex Albiziae decoct rat oral gavage can suppress its peritoneum mast cell degranulation, in vitro tests also has similar effect.Cortex Albiziae decoct can obviously suppress antigen (horse serum) to the sensitization process of rat and antibody production process.Cortex Albiziae is the bark of leguminous plant Herba Albiziae, Cortex Albiziae another name closes confused skin, night platform skin, Herba Albiziae veneer, Cortex Albiziae has the resolving depression of calming the nerves, the effect of the eliminating carbuncle of invigorating blood circulation, Cortex Albiziae has the effect for the treatment of irritability, melancholy, sleeplessness, inside and outside carbuncle and ulcer, traumatic injury, gastritis sufferer is careful takes Cortex Albiziae, and wind heat spontaneous perspiration, diseases caused by exogenous pathogenic factor sleeplessness person prohibit and take Cortex Albiziae.

Radix et Caulis Opuntiae Dillenii: hardship, cool.Function cures mainly: heat-clearing and toxic substances removing, dissipating blood stasis for subsidence of swelling, benefiting stomach and stopping pain, antitussive.For Stomach duodenum ulcer, acute dysentery, cough; Mumps is controlled in external, mastitis, carbuncle furuncle and phyma poison, venom, burn and scald.

Herba Menthae: one of Chinese conventional Chinese medicine.It is pungent cool property sweating antipyretic medicine, controls influenza, headache, conjunctival congestion, fever of the body, throat, the dental bed disease such as swell and ache.Place with can training the mind dysmenorrhoea, skin pruritus, erythra and eczema etc.All herbal medicine, pungent, cool.Return lung, Liver Channel, there is the wind heat of dispersing, clearing throat, rash removing toxic substances, dispersing the stagnated live-QI to relieve the stagnation of QI and the effect such as antipruritic, be applicable to that cold, fever, headache, laryngopharynx swelling and pain, lossless, wind-fire acute conjunctivitis, rubella, skin are itched, the disease such as colic, dysentery and scrofula, external has slight analgesic effect, for neuralgia etc.

Rhizoma Atractylodis: drying damp and strengthening spleen, expelling wind and cold, improving eyesight.For distension and fullness in the abdomen, the edema of having loose bowels, beriberi flaccidity of feet with lamenness, rheumatic arthralgia, anemofrigid cold, nyctalopia.Rhizoma Atractylodis have drying damp and strengthening spleen, the effect of wind-damp dispelling.Cure mainly retention of dampness in middle-JIAO, anemofrigid-damp arthralgia, foot swelling and pain in knee, flaccidity is soft unable, nyctalopia nyctalopia.< < pearl sac > > day: " can stomach invigorating pacify spleen, non-this of all damp-edema can not remove." < < Compendium of Materia Medica > > says: " control damp-phlegm prolonged fluid-retention ... and spleen is wet dirty, turbid drop leukorrhagia, the sliding hemorrhoidal hamorrhage that rushes down." < < Newly Revised Canon of Materia Medica > > claims that it can " diuresis ".

Pericarpium Citri Reticulatae: nature and flavor are bitter, pungent, temperature.Return lung, spleen channel.There is regulating qi-flowing for strengthening spleen, the function of drying dampness to eliminate phlegm.Can be used for fullness in the epigastrium and chest, lack of appetite and vomiting, cough with copious phlegm.Therefore Pericarpium Citri Reticulatae has three major types effect, the one, lead cold-evil in the heart, two broken stagnant gas, three strengthening the spleen stomaches.This three greatly on, Main Function is row QI of the spleen and stomach.The main transmitting and distributing the fluids of taste, therefore QI of the spleen and stomach capablely can dry, spleen invigorating, reduce phlegm, therefore can say again, Pericarpium Citri Reticulatae temperature can be supported spleen, pungent can being amusing, bitter can spleen invigorating.Due to the main row QI of the spleen and stomach of Pericarpium Citri Reticulatae, taste are located in middle Jiao, and middle Jiao's gas is current, and the gas of three warmers is also sprung up thereupon.Three warmers are the organ in charge of water circulation, and current water liquid, accompanies with wetting phase; Again for hiding mansion outside mansion, the upper and heart, lung, lower and liver, kidney.So the effect of Pericarpium Citri Reticulatae can wide and all Zang Fu, spread all over whole body wet.From lung, say, pungent loose lung qi, hardship is let out lung qi, and temperatureization cold can be controlled abundant expectoration cough with asthma, and gas is stopped up food and is stopped; From the heart, say, pungent happy gas, hardship is let out heart-fire, and warm removing dampness is turbid, can control irritable feverish sensation in the chest, and the implication sound of vomiting is smelly; From liver, say, pungent loose stagnation of liver-QI, liver-fire falls in hardship, warming for eliminaring cold-damp, so its can treating the liver strongly fragrantly has heat, drink is stopped eating stagnant; From kidney, say, pungent profit kidney is dry, and it is wet that hardship is let out kidney, and gentle kidney qi, so it can control life fire deficiency, indigestion.Certainly, all explanations, all with wet relevant with spleen, so its property of medicine effect performance leeway is larger, all can be used in general activating QI to eliminate phlegm side.Anesthetized rabbit, cat, dog intravenous injection are had to hypotensive effect slowly, and its decompression principle is owing to directly acting on vascular smooth muscle.

Rhizoma Coptidis: hardship, cold, nontoxic.GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel.Cure mainly: hot dampness, eliminating fire and detoxication.For damp and hot feeling of fullness, vomiting acid regurgitation, dysentery, jaundice, unconsciousness due to high fever, hyperactivity of heart-fire, dysphoria and insomnia, heat in blood is told nosebleed, conjunctival congestion, toothache, quenches one's thirst, carbuncle furuncle; External treatment eczema, eczema, auditory meatus is suppurated.The kind clear part of the body cavity above the diaphragm housing the heart and lungs of Rhizoma Coptidis (processed with wine) is burning hot.For conjunctival congestion, aphtha.Prepared RHIZOMA COPTIDIS with rhizoma zingiberis recens juice clearing stomach stomach function regulating preventing or arresting vomiting.For cold and heat, tie mutually damp and hot middle resistance, feeling of fullness vomiting.Cornel Rhizoma Coptidis soothing liver-QI stomach function regulating preventing or arresting vomiting.For incoordination between the liver and stomach, vomiting acid regurgitation.

Polyalthia nemoralis A. D C.: sweet, flat.Function cures mainly: spleen reinforcing stomach invigorating, tonifying the kidney to consolidate the essence.Cure mainly chronic gastritis, inappetence, myasthenia of limbs, seminal emission.

When the dosage form of pharmaceutical composition is capsule, described preparation method comprises the following steps:

When the dosage form of pharmaceutical composition is oral liquid, described preparation method comprises the following steps:

When the dosage form of pharmaceutical composition is tablet, described preparation method comprises the following steps:

Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure of reaching technique effect can fully understand and implement according to this.

Embodiment 1 capsule

It is a kind of for alleviating the pharmaceutical composition of malaise after chemicotherapy that embodiments of the invention provide, dosage form is capsule, the parts by weight of its each raw medicinal material are: Radix Codonopsis 23 weight portions, the Radix Astragali 22 weight portions, Rhizoma Dioscoreae 15 weight portions, Radix Glycyrrhizae 15 weight portions, Fructus Jujubae 21 weight portions, Radix Et Caulis Acanthopanacis Senticosi 20 weight portions, Fructus Hippophae 15 weight portions, Placenta Hominis 7 weight portions, Herba Pimpinellae thellungianae 15 weight portions, Arillus Longan 8 weight portions, Bulbus Lilii 21 weight portions, Radix Ophiopogonis 17 weight portion, Fructus Mori 15 weight portions, Fructus Tritici Levis 15 weight portions, Fructus Schisandrae Chinensis 17 weight portions, Semen Nelumbinis 15 weight portions, Poria cum Radix Pini's 15 weight portions, Rhizoma et radix valerianae 15 weight portions, Caulis Polygoni Multiflori 15 weight portions, Herb Gynostemmae Pentaphylli 15 weight portions, Ganoderma 23 weight portions, Herba Viviae Sativae 21 weight portions and Cortex Albiziae 11 weight portions.

Its preparation method comprises the following steps:

Step a, cross 120 order dusting covers after described raw medicinal material is put into pulverizer and pulverized, the fine powder amount that enable pass is crossed 120 mesh sieves is reaching 35%, collects by the raw material fine powder of 120 mesh sieves standby;

Step b, remaining particulate matter after sieving in step a is put into the ethanol heating and refluxing extraction 2 times that ratio of weight and number is 6 times of amounts, each 1.5 hours, 2 extracting solution are merged standing;

Step c, the medicinal residues that in step b, ethanol extraction is crossed are added to ratio of weight and number is 6 times of water gaging heating and refluxing extraction 2 times, each 1.5 hours, 2 extracting solution is merged standing;

Steps d, above-mentioned two kinds of extracting solution are merged, the filtrate of 1.38 o'clock when concentrating under reduced pressure relative density is 55 ℃, reclaims ethanol, and gained filtrate is adjusted to proportion to 1.06, pass into spray dryer and spray dryly, the compressed air pressure of crossing spray dryer shower nozzle is 4kg/m ², hothouse hot stream temperature is 100 ℃, obtains raw material medicated powder; The raw material fine powder obtaining after sieving is mixed and incapsulated with raw material medicated powder.

Embodiment 2 oral liquids

It is a kind of for alleviating the pharmaceutical composition of malaise after chemicotherapy that embodiments of the invention provide, dosage form is oral liquid, the parts by weight of its each raw medicinal material are: Radix Codonopsis 21 weight portions, the Radix Astragali 19 weight portions, Rhizoma Dioscoreae 19 weight portions, Radix Glycyrrhizae 14 weight portions, Fructus Jujubae 21 weight portions, Radix Et Caulis Acanthopanacis Senticosi 20 weight portions, Fructus Hippophae 14 weight portions, Placenta Hominis 12 weight portions, Herba Pimpinellae thellungianae 15 weight portions, Arillus Longan 7 weight portions, Bulbus Lilii 20 weight portions, Radix Ophiopogonis 17 weight portion, Fructus Mori 16 weight portions, Fructus Tritici Levis 16 weight portions, Fructus Schisandrae Chinensis 17 weight portions, Semen Nelumbinis 15 weight portions, Poria cum Radix Pini's 15 weight portions, Rhizoma et radix valerianae 14 weight portions, Caulis Polygoni Multiflori 14 weight portions, Herb Gynostemmae Pentaphylli 14 weight portions, Ganoderma 25 weight portions, Herba Viviae Sativae 21 weight portions, Cortex Albiziae 10 weight portions, Radix et Caulis Opuntiae Dillenii 15 weight portions, Herba Menthae 13 weight portions, Rhizoma Atractylodis 15 weight portions, Pericarpium Citri Reticulatae 17 weight portions, Rhizoma Coptidis 22 weight portions and Polyalthia nemoralis A. D C. 15 weight portions.

Its preparation method comprises the following steps:

The first step, Placenta Hominis, Herba Pimpinellae thellungianae, Arillus Longan, Bulbus Lilii, Radix Ophiopogonis, Fructus Mori, Fructus Tritici Levis and Fructus Schisandrae Chinensis are mixed, the alcohol reflux that to add with respect to 7 times, mixture amount determining alcohols be 90% 3 times, each 4 hours, filter respectively, each time filtrate merges, and reclaims ethanol, be concentrated into the mastic that 70 ℃ of relative densities are 1.37, standby;

Second step, is mixed in proportion surplus stock medical material, adds with respect to 6 times of water gagings of mixture, boils 4 hours, filters, and is concentrated into the mastic that 70 ℃ of relative densities are 1.33;

The 3rd step, the described mastic that the first step, second step are obtained mixes, and 75 ℃ of reduced vacuum are dry, and powder gets dry extract;

The 4th step, will the 3rd add ethanol in the described dried cream powder that obtains of step, obtain containing alcohol mastic, and described is 65% containing alcohol mastic containing alcohol amount; By described, containing alcohol mastic, carry out successively cold preservation processing, precipitation process, filtration treatment, recovery Ethanol Treatment, obtain dealcoholysis mastic, wherein, the cold preservation processing time is 36 hours, and refrigerated storage temperature is 5 ℃;

The 5th step, will add cane sugar powder, active carbon in described dealcoholysis mastic, carries out successively heat treated, filtration treatment, dilution process, obtains semi-finished product; The weight ratio of described dealcoholysis mastic and described cane sugar powder is 1: 0.2～0.35; The weight ratio of described dealcoholysis mastic and described active carbon is 1: 0.004; The time of described heat treated is 75 minutes, and temperature is 170 ℃;

Embodiment 3 tablets

It is a kind of for alleviating the pharmaceutical composition of malaise after chemicotherapy that embodiments of the invention provide, dosage form is tablet, the parts by weight of its each raw medicinal material are: Radix Codonopsis 25 weight portions, the Radix Astragali 25 weight portions, Rhizoma Dioscoreae 15 weight portions, Radix Glycyrrhizae 10 weight portions, Fructus Jujubae 25 weight portions, Radix Et Caulis Acanthopanacis Senticosi 25 weight portions, Fructus Hippophae 10 weight portions, Placenta Hominis 10 weight portions, Herba Pimpinellae thellungianae 10 weight portions, Arillus Longan 10 weight portions, Bulbus Lilii 15 weight portions, Radix Ophiopogonis 20 weight portion, Fructus Mori 10 weight portions, Fructus Tritici Levis 20 weight portions, Fructus Schisandrae Chinensis 15 weight portions, Semen Nelumbinis 20 weight portions, Poria cum Radix Pini's 10 weight portions, Rhizoma et radix valerianae 10 weight portions, Caulis Polygoni Multiflori 10 weight portions, Herb Gynostemmae Pentaphylli 10 weight portions, Ganoderma 30 weight portions, Herba Viviae Sativae 25 weight portions, Cortex Albiziae 8 weight portions, Radix et Caulis Opuntiae Dillenii 20 weight portions, Herba Menthae 10 weight portions, Rhizoma Atractylodis 20 weight portions, Pericarpium Citri Reticulatae 20 weight portions, Rhizoma Coptidis 25 weight portions and Polyalthia nemoralis A. D C. 10 weight portions.

Its preparation method comprises the following steps:

The first step, is mixed in proportion described each raw medicinal material, adds the ethanol that the determining alcohol with respect to 4.5 times of mixture qualities is 85%, and reflux 3 hours is extracted, and filters and obtains the first extracting solution; The medicinal residues that filter to obtain add the ethanol that the determining alcohol with respect to 2 times of described medicinal residues quality is 90% again, and reflux 2 hours, extracts, and filters and obtains the second extracting solution; The first extracting solution and the second extracting solution are merged, and concentrating under reduced pressure is removed alcohol solvent, dry, obtains and gets dry extract;

Second step, the dry cream that the first step is obtained is placed in super micron mill to be pulverized 2.5 hours, pulverizes, and sieves, and obtains 350 object micropowders;

The 3rd step, the micropowders that second step is obtained, adds microcrystalline Cellulose with respect to 0.2 times of its quality, 0.2 times of lactose, the starch of 0.3 times, sieves, mix homogeneously, granulates, dry, adds with respect to 0.03 times of magnesium stearate of micropowders quality, granulate, tabletting, makes.

Toxicity test

Acute toxicity test: 60 of application NIH mices, SPF level, male and female half and half, body weight 17～24g, carries out acute toxicity test.Mice is divided into two groups at random, and 20 every group, matched group and administration group, test front fasting 12 hours; The capsule of embodiments of the invention 1 preparation is dissolved in water, (concentration is 5.74g crude drug/ml, maximum concentration) gavage, gavage volume is that 5ml/kg(is that single-dose dosage is 28.7 crude drugs/kg), matched group gives equivalent normal saline, administration in a day 2 times, delivery time 6 hours, after administration, Continuous Observation is 14 days, and record mice toxic reaction and death toll.Experimental result shows: with matched group comparison, after administration, mice has no notable difference, experiment Continuous Observation 14 days, and mice overall health of patients, diet, drinking-water, body weight gain are all normal.Mice oral administration gavage tablet LD50>28.7 of the present invention crude drug/kg, every day, maximum dosage-feeding was 57.4 crude drugs/kg/ day.Chinese medicine clinical application amount of the present invention is 4.6g crude drug/day/people, becomes body weight for humans in 60KG, and average dosage is 0.077g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight take 21g) oral administration gavage Chinese medicine of the present invention is quantity 745 times.Therefore capsule acute toxicity of the present invention is low, clinical drug safety.With the tablet of the embodiment of the present invention 3, test according to the method described above, result proof tablet acute toxicity is low, clinical drug safety.

Long term toxicity test: by the Oral Liquid On Mice of the embodiment of the present invention 2 by 6.43,15.72 and 16 weeks (1.0ml/100g body weight of 36.41g crude drug/kg continuous use, every day 2 times) and drug withdrawal after 4 weeks, result shows: Chinese medicine preparation of the present invention all has no significant effect indexs such as the hair of mice, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat, internal organs naked eyes do not find that difference changes and histological examination result shows, medication 16 weeks and drug withdrawal are after 4 weeks, and Organs of Mice is all without obviously changing.Illustrate that toxicity is little after Chinese medicine preparation of the present invention is to mice long-term prescription, after drug withdrawal, also there is no difference reaction, application safety.

Clinical data

Case selection: fetch and come from the routine chemicotherapy patient of the court's oncology tumour patient 160, male 78 examples, female's 82 examples; Age 24-72 year, 41.5 years old mean age, need patient's 108 examples of chemotherapy, need patient's 52 examples of chemotherapy; 160 routine patients are divided into four groups at random, and every group of 40 examples, are respectively embodiment group 1, embodiment group 2, embodiment group 3 and matched group, and each experimental group case is at age, sex, the tumor state of an illness and chemicotherapy equal no significant difference aspect the cycle.

Above-mentioned 160 routine patients are according to knub position and different chemicotherapy time cycle of state of an illness different choice, because chemicotherapy is being catched and killed outside cancerous cell, also can involve normal cell, damage immune system, middle or the time of having a rest in later stage at chemicotherapy, all there is the classical symptom of malaise in patient, and with stomach poor appetite, moves back the symptoms such as lassitude.Deficiency of vital energy damage person main manifestations is shallow complexion, physical fatigue and lassitude of spirit, lazy speech low voice, spontaneous perspiration, thready pulse; Blood deficiency damage person main manifestations is lustreless complexion, the lips and nails being pale, dizziness and blurred vision, thready pulse; Deficiency of YIN damage person main manifestations is that dry mouth and tougue, dysphoria with feverish sensation in the chest palms and soles, night sweat, red tongue tongue are few, thready and rapid pulse; Yang deficiency damage person main manifestations is that pale complexion, coldness of the body with chills, pale tongue are fat that tooth prints, deep-thready pulse.Above-mentioned 160 routine patients take medicine of the present invention for chemicotherapy after finishing, and according to concrete symptom, taking the medicine of the present invention time is 2 weeks-2 months.

Therapeutic Method:

Embodiment group 1: the middle and later stage rest period at chemicotherapy, the capsule of the use embodiment of the present invention 1, every day three times, each 4;

Embodiment group 2: the middle and later stage rest period at chemicotherapy, the oral liquid of the use embodiment of the present invention 2, every day three times, each 30ml;

Embodiment group 3: the middle and later stage rest period at chemicotherapy, the tablet of the use embodiment of the present invention 3, every day three times, each 4;

Matched group: do not use any medicine;

Wherein, till the drug administration of embodiment group 1-3 to the next chemicotherapy cycle starts or take 2 weeks-2 months according to symptom, other diet are identical with matched group, note at ordinary times selenium supplement, and reasonably combined meals should be selected food nutritious and that be easy to digest.

Curative effect determinate standard: effective: muscle power and appetite obviously recover normal, and sleep and spirit are good, and it is normal that complexion and pulse recover substantially; Effective: muscle power and appetite are recovered normally substantially, and sleep quality is better, and the mental status is relatively good; Invalid: limbs fatigue, inappetence, lethargy.

Therapeutic outcome:

The patient of embodiment group 1-3 starts to take medicine of the present invention from last chemicotherapy finishes, according to concrete symptom difference, take at most after 2 months, therapeutic outcome is as shown in table 1, adopt pharmaceutical composition of the present invention to alleviate chemicotherapy after malaise have advantages of effective, safe and have no side effect.

Each experimental group therapeutic outcome synopsis example of table 1

Group	Number of cases	Effective	Effectively	Invalid	Effective percentage
						Embodiment group 1	40	9	19	12	70%
Embodiment group 2	40	12	20	8	80%
						Embodiment group 3	40	11	19	10	75%
Matched group	40	2	5	33	17.5%

Known according to the clinical statistics in above table, medicine provided by the invention malaise after alleviating chemicotherapy is effective, safe, has no side effect.

Model case:

Case 1: Lin, man, 52 years old, superior lobe of right lung scale cancer, carry out 2 cycles of chemotherapy, between twice chemotherapy, stop having a rest for three weeks, after end of chemotherapy, there is shallow complexion for the first time, physical fatigue and lassitude of spirit, myasthenia of limbs, lazy speech low voice, spontaneous perspiration, the side effect such as thready pulse, taking the oral liquid of the embodiment of the present invention 2 treats, every day three times, each 30ml, take continuously after 2 weeks, side effect symptom after chemotherapy obviously alleviates, extremity are strong, spirit is good, continue to take after 1 week, it is normal that appetite is recovered substantially, according to Lin, give an oral account record, take about 3 weeks, muscle power is basic recovers normal, mental status is good.

Case 2: bent certain, female, 49 years old, after esophageal carcinoma radiotherapy eight times, there is the symptom of complexion jaundice, physical fatigue and lassitude of spirit, general weakness, vomiting anorexia, take the tablet of the embodiment of the present invention 3, every day three times, each 4, take continuously after 4 weeks, symptom makes moderate progress, and continues to take 4 weeks, and symptom is obviously improved, diet increases, and extremity are strong, independently basic housework, body constitution improves, and follows up a case by regular visits to 1 year, does not occur untoward reaction.

The foregoing is only preferred embodiment of the present invention, in order to limit the present invention, within the spirit and principles in the present invention not all, any modification of doing, be equal to replacement, improvement etc., within all should being included in protection scope of the present invention.

Claims

1. for alleviating the pharmaceutical composition of malaise after chemicotherapy, it is characterized in that, described pharmaceutical composition comprises following raw medicinal material: Radix Codonopsis, the Radix Astragali, Rhizoma Dioscoreae, Radix Glycyrrhizae, Fructus Jujubae, Radix Et Caulis Acanthopanacis Senticosi, Fructus Hippophae, Placenta Hominis, Herba Pimpinellae thellungianae, Arillus Longan, Bulbus Lilii, Radix Ophiopogonis, Fructus Mori, Fructus Tritici Levis, Fructus Schisandrae Chinensis, Semen Nelumbinis, Poria cum Radix Pini, Rhizoma et radix valerianae, Caulis Polygoni Multiflori, Herb Gynostemmae Pentaphylli, Ganoderma, Herba Viviae Sativae and Cortex Albiziae.

2. according to claim 1 for alleviating the pharmaceutical composition of malaise after chemicotherapy, it is characterized in that, in described pharmaceutical composition, the parts by weight of each raw medicinal material are: Radix Codonopsis 15-30 weight portion, Radix Astragali 15-30 weight portion, Rhizoma Dioscoreae 10-20 weight portion, Radix Glycyrrhizae 10-20 weight portion, Fructus Jujubae 15-25 weight portion, Radix Et Caulis Acanthopanacis Senticosi 15-25 weight portion, Fructus Hippophae 10-20 weight portion, Placenta Hominis 5-10 weight portion, Herba Pimpinellae thellungianae 10-20 weight portion, Arillus Longan 5-10 weight portion, Bulbus Lilii 15-25 weight portion, Radix Ophiopogonis 15-20 weight portion, Fructus Mori 10-20 weight portion, Fructus Tritici Levis 10-20 weight portion, Fructus Schisandrae Chinensis 15-20 weight portion, Semen Nelumbinis 10-20 weight portion, Poria cum Radix Pini 10-20 weight portion, Rhizoma et radix valerianae 10-20 weight portion, Caulis Polygoni Multiflori 10-20 weight portion, Herb Gynostemmae Pentaphylli 10-20 weight portion, Ganoderma 15-30 weight portion, Herba Viviae Sativae 15-25 weight portion and Cortex Albiziae 5-15 weight portion.

3. according to claim 1 and 2 for alleviating the pharmaceutical composition of malaise after chemicotherapy, it is characterized in that, in described pharmaceutical composition, the parts by weight of each raw medicinal material are: Radix Codonopsis 23 weight portions, the Radix Astragali 22 weight portions, Rhizoma Dioscoreae 15 weight portions, Radix Glycyrrhizae 15 weight portions, Fructus Jujubae 21 weight portions, Radix Et Caulis Acanthopanacis Senticosi 20 weight portions, Fructus Hippophae 15 weight portions, Placenta Hominis 7 weight portions, Herba Pimpinellae thellungianae 15 weight portions, Arillus Longan 8 weight portions, Bulbus Lilii 21 weight portions, Radix Ophiopogonis 17 weight portion, Fructus Mori 15 weight portions, Fructus Tritici Levis 15 weight portions, Fructus Schisandrae Chinensis 17 weight portions, Semen Nelumbinis 15 weight portions, Poria cum Radix Pini's 15 weight portions, Rhizoma et radix valerianae 15 weight portions, Caulis Polygoni Multiflori 15 weight portions, Herb Gynostemmae Pentaphylli 15 weight portions, Ganoderma 23 weight portions, Herba Viviae Sativae 21 weight portions and Cortex Albiziae 11 weight portions.

According to described in claim 1-3 any one for alleviating the pharmaceutical composition of malaise after chemicotherapy, it is characterized in that, described pharmaceutical composition also comprises: Radix et Caulis Opuntiae Dillenii, Herba Menthae, Rhizoma Atractylodis, Pericarpium Citri Reticulatae, Rhizoma Coptidis and Polyalthia nemoralis A. D C..

According to described in claim 1-4 any one for alleviating the pharmaceutical composition of malaise after chemicotherapy, it is characterized in that, in described pharmaceutical composition, the parts by weight of each raw medicinal material are: Radix Codonopsis 15-25 weight portion, Radix Astragali 15-25 weight portion, Rhizoma Dioscoreae 15-25 weight portion, Radix Glycyrrhizae 10-20 weight portion, Fructus Jujubae 15-25 weight portion, Radix Et Caulis Acanthopanacis Senticosi 15-25 weight portion, Fructus Hippophae 10-20 weight portion, Placenta Hominis 10-15 weight portion, Herba Pimpinellae thellungianae 10-20 weight portion, Arillus Longan 5-10 weight portion, Bulbus Lilii 15-25 weight portion, Radix Ophiopogonis 15-20 weight portion, Fructus Mori 10-20 weight portion, Fructus Tritici Levis 10-20 weight portion, Fructus Schisandrae Chinensis 15-20 weight portion, Semen Nelumbinis 10-20 weight portion, Poria cum Radix Pini 10-20 weight portion, Rhizoma et radix valerianae 10-20 weight portion, Caulis Polygoni Multiflori 10-20 weight portion, Herb Gynostemmae Pentaphylli 10-20 weight portion, Ganoderma 15-30 weight portion, Herba Viviae Sativae 15-25 weight portion, Cortex Albiziae 8-15 weight portion, Radix et Caulis Opuntiae Dillenii 10-20 weight portion, Herba Menthae 10-15 weight portion, Rhizoma Atractylodis 10-20 weight portion, Pericarpium Citri Reticulatae 10-20 weight portion, Rhizoma Coptidis 15-25 weight portion and Polyalthia nemoralis A. D C. 10-20 weight portion.

According to described in claim 1-5 any one for alleviating the pharmaceutical composition of malaise after chemicotherapy, it is characterized in that, in described pharmaceutical composition, the parts by weight of each raw medicinal material are: Radix Codonopsis 21 weight portions, the Radix Astragali 19 weight portions, Rhizoma Dioscoreae 19 weight portions, Radix Glycyrrhizae 14 weight portions, Fructus Jujubae 21 weight portions, Radix Et Caulis Acanthopanacis Senticosi 20 weight portions, Fructus Hippophae 14 weight portions, Placenta Hominis 12 weight portions, Herba Pimpinellae thellungianae 15 weight portions, Arillus Longan 7 weight portions, Bulbus Lilii 20 weight portions, Radix Ophiopogonis 17 weight portion, Fructus Mori 16 weight portions, Fructus Tritici Levis 16 weight portions, Fructus Schisandrae Chinensis 17 weight portions, Semen Nelumbinis 15 weight portions, Poria cum Radix Pini's 15 weight portions, Rhizoma et radix valerianae 14 weight portions, Caulis Polygoni Multiflori 14 weight portions, Herb Gynostemmae Pentaphylli 14 weight portions, Ganoderma 25 weight portions, Herba Viviae Sativae 21 weight portions, Cortex Albiziae 10 weight portions, Radix et Caulis Opuntiae Dillenii 15 weight portions, Herba Menthae 13 weight portions, Rhizoma Atractylodis 15 weight portions, Pericarpium Citri Reticulatae 17 weight portions, Rhizoma Coptidis 22 weight portions and Polyalthia nemoralis A. D C. 15 weight portions.

According to described in claim 1-6 any one for alleviating the preparation method of the pharmaceutical composition of malaise after chemicotherapy, it is characterized in that, the dosage form of described pharmaceutical composition is capsule, described preparation method comprises the following steps:

According to described in claim 1-6 any one for alleviating the preparation method of the pharmaceutical composition of malaise after chemicotherapy, it is characterized in that, the dosage form of described pharmaceutical composition is oral liquid, described preparation method comprises the following steps:

According to described in claim 1-6 any one for alleviating the preparation method of the pharmaceutical composition of malaise after chemicotherapy, it is characterized in that, the dosage form of described pharmaceutical composition is tablet, described preparation method comprises the following steps: