CN103920011A

CN103920011A - Pharmaceutical composition for postpartum liver depression qi stagnation type hypogalactia and preparing method thereof

Info

Publication number: CN103920011A
Application number: CN201410195317.5A
Authority: CN
Inventors: 许文; 吕明云
Original assignee: Individual
Current assignee: Individual
Priority date: 2014-05-12
Filing date: 2014-05-12
Publication date: 2014-07-16
Also published as: CN105535486A

Abstract

The invention discloses a pharmaceutical composition for liver qi stagnation type hypogalactia and a preparing method thereof. The pharmaceutical composition comprises the following raw medical materials of pericarpium citri reticulatae viride, semen litchi, rhizoma cyperi, finger citron, citron fruits, roses, Armeniaca mume, semen aesculi, herba aristolochiae, corydalis decumbens, herba leonuri, herba lycopi, caulis spatholobi, cowherb seeds, valeriana officinalis, cortex albiziae, radix codonopsis, astragalus, yam, rhodiola, sea buckthorn, micromeria biflora benth, lilies, radix ophiopogonis and goodyera kwangtungensis tso. The pharmaceutical composition has the advantages that the traditional theories of traditional Chinese medicine are utilized, the pharmaceutical composition is mainly used for soothing liver-qi stagnation and activating collaterals and promoting lactation, the major function of the pharmaceutical composition is treating the liver qi stagnation type hypogalactia, and the pharmaceutical composition is quick in effect, accurate in curative effect, high in security, non-poisonous and non-side-effect, and the live qi stagnation type hypogalactia can not easily occur.

Description

Be used for pharmaceutical composition of caused by hepatic stagnation qi stagnation hypogalactia in puerperal and preparation method thereof

Technical field

The present invention relates to pharmaceutical technology, relate in particular to a kind of pharmaceutical composition and preparation method for caused by hepatic stagnation qi stagnation hypogalactia in puerperal.

Background technology

Puerpera when suckling milk very less or completely without, enough even can feeding infant person, be called puerperal hypogalactia.Degree and the situation of hypogalactia are different: during the beginning suckling that has, lack, and later slightly many but still inadequate; Have completely without milk, can not feed breast completely; The normal suckling having, after unexpected high heat or seven emotions are crossed extremely, milk is suddenly few, is not enough to feeding infant.

Clinical symptoms: mostly occur 2-3 days puerperal to two weeks.Galactopoiesis, except closely related with development of breast, is sucked stimulation while depending on suckling to a great extent.In addition, closely related with puerpera's nutrition, sleep, health status and emotion.

Chinese medicine thinks, between age of sucking, puerpera's milk very less or completely without, be called " hypogalactia ", also claim " galactozemia " or " hypogalactia ".Common typing has deficient qi and blood and stagnation of QI due to depression of the liver.Weak type of qi and blood: plain body deficient qi and blood, the multiple consumption gas of losing blood when producing, deficiency of qi and blood, or weakness of the spleen and stomach, insufficiency of generating and transforming QI and blood, so that being difficult of deficient qi and blood is newborn, puerperal milk very less or completely without.Caused by hepatic stagnation qi stagnation: the damaged by excess of seven emotions of depression, or puerperal without hesitation, liver is lost bar and reaches, functional activity of QI being not smooth, disorder of QI and blood, so that passages through which vital energy circulates is not smooth, hinders milk operation, thereby hypogalactia.Wherein, the main syndromes of caused by hepatic stagnation qi stagnation is: puerperal, milk was puckery few, dense thick, or agalactia, the hard pain of mammary swelling, and depressed emotion, breast side of body feeling of distension and oppression, inappetence, or slight fever, body of the tongue is normal, yellow and thin fur, stringy and thready pulse or stringy and rapid pulse.

Breast milk is baby's the most natural, the safest, most complete unique natural food of growing up.It contains grow up required nutritious and antibody, particularly breast milk of baby and contains 50 percent fat, except supplying with baby's body heat, also meets the required fat of baby's brain development (structure of brain 60 percent comes from fat); Abundant calcium and phosphorus can make the long height of baby strong again; Immunoglobulin can effectively prevent and protect baby to avoid the generation of infection and chronic disease; Than must the factor and oligosaccharide can suppress intestinal pathogenic bacteria hypertrophy and help digest.In addition, intimate contact and the paternity of feeding breast milk can stimulate baby's brain and mental development, feed breast milk simultaneously and can promote mother's uterine contraction again, keep good stature, so feed breast milk, are that baby and mother are had to very large benefit.

But western medical treatment puerperal hypogalactia, still lacks clinical treatment medicine effectively at present, Chinese medicine is accumulating abundant clinical experience and treatment theory aspect control puerperal hypogalactia.There have been the Chinese Traditional Medicines of multiple control puerperal hypogalactia in clinical market, but, according to the different clinical symptoms of patient, sign, different individual body constitution, existing Chinese Traditional Medicines are also not enough to meet the demand in clinical market, this just need to produce a kind of can be for specific clinical manifestation, specific clinical disease typing, carry out magnetic target therapy, the significant new drug of clinical efficacy.

Summary of the invention

Technical problem to be solved by this invention is, a kind of pharmaceutical composition that is used for the treatment of caused by hepatic stagnation qi stagnation hypogalactia in puerperal and preparation method thereof is provided, this pharmaceutical composition be take dispersing the stagnated live-QI to relieve the stagnation of QI, active lactogenesis as main, and treatment caused by hepatic stagnation qi stagnation hypogalactia in puerperal has rapid-action, determined curative effect, safe, the advantage that has no side effect and be difficult for recurring.

In order to solve the problems of the technologies described above, the invention provides a kind of pharmaceutical composition that is used for the treatment of caused by hepatic stagnation qi stagnation hypogalactia in puerperal, wherein, comprise following raw medicinal material: Pericarpium Citri Reticulatae Viride, Semen Litchi, Rhizoma Cyperi, Fructus Citri Sarcodactylis, Fructus Citri, Flos Rosae Rugosae, FLOS MUME, Semen Aesculi, Herba Aristolochiae, Rhizoma Corydalis Decumbentis, Herba Leonuri, Herba Lycopi, Caulis Spatholobi, Semen Vaccariae, Rhizoma et radix valerianae, Cortex Albiziae, Radix Codonopsis, the Radix Astragali, Rhizoma Dioscoreae, Radix Rhodiolae, Fructus Hippophae, Herba Micromeriae Biflorae, Bulbus Lilii, Radix Ophiopogonis and Oxyria sinensis Hemsl..

In described pharmaceutical composition, the parts by weight of each raw medicinal material are preferably: Pericarpium Citri Reticulatae Viride 10-20 weight portion, Semen Litchi 10-20 weight portion, Rhizoma Cyperi 15-25 weight portion, Fructus Citri Sarcodactylis 10-20 weight portion, Fructus Citri 10-20 weight portion, Flos Rosae Rugosae 10-20 weight portion, FLOS MUME 10-20 weight portion, Semen Aesculi 15-25 weight portion, Herba Aristolochiae 10-20 weight portion, Rhizoma Corydalis Decumbentis 10-15 weight portion, Herba Leonuri 15-25 weight portion, Herba Lycopi 15-25 weight portion, Caulis Spatholobi 10-20 weight portion, Semen Vaccariae 5-15 weight portion, Rhizoma et radix valerianae 10-20 weight portion, Cortex Albiziae 10-20 weight portion, Radix Codonopsis 10-20 weight portion, Radix Astragali 15-25 weight portion, Rhizoma Dioscoreae 15-25 weight portion, Radix Rhodiolae 5-10 weight portion, Fructus Hippophae 10-20 weight portion, Herba Micromeriae Biflorae 10-20 weight portion, Bulbus Lilii 15-25 weight portion, Radix Ophiopogonis 10-20 weight portion and Oxyria sinensis Hemsl. 10-20 weight portion.

In described pharmaceutical composition, the parts by weight of each raw medicinal material also can be preferably: Pericarpium Citri Reticulatae Viride 15 weight portions, Semen Litchi 16 weight portions, Rhizoma Cyperi 21 weight portions, Fructus Citri Sarcodactylis 15 weight portions, Fructus Citri 15 weight portions, Flos Rosae Rugosae 15 weight portions, FLOS MUME 13 weight portions, Semen Aesculi 17 weight portions, Herba Aristolochiae 14 weight portions, Rhizoma Corydalis Decumbentis 12 weight portions, Herba Leonuri 20 weight portions, Herba Lycopi's 19 weight portions, Caulis Spatholobi 15 weight portions, Semen Vaccariae 8 weight portions, Rhizoma et radix valerianae 15 weight portions, Cortex Albiziae 12 weight portions, Radix Codonopsis 16 weight portions, the Radix Astragali 20 weight portions, Rhizoma Dioscoreae 20 weight portions, Radix Rhodiolae 7 weight portions, Fructus Hippophae 15 weight portions, Herba Micromeriae Biflorae 15 weight portions, Bulbus Lilii 21 weight portions, Radix Ophiopogonis 15 weight portion and Oxyria sinensis Hemsl. 15 weight portions.

Described pharmaceutical composition also comprises: Rhizoma alpiniae pumilae, volume stem knotweed, Radix Oryzae Glutinosae, Folium Fumicis Dentati and Herba Hemisteptae Lyratae.

In described pharmaceutical composition, the parts by weight of each raw medicinal material are preferably: Pericarpium Citri Reticulatae Viride 10-20 weight portion, Semen Litchi 10-20 weight portion, Rhizoma Cyperi 15-25 weight portion, Fructus Citri Sarcodactylis 10-20 weight portion, Fructus Citri 10-20 weight portion, Flos Rosae Rugosae 10-20 weight portion, FLOS MUME 10-20 weight portion, Semen Aesculi 15-25 weight portion, Herba Aristolochiae 10-20 weight portion, Rhizoma Corydalis Decumbentis 10-15 weight portion, Herba Leonuri 15-25 weight portion, Herba Lycopi 15-25 weight portion, Caulis Spatholobi 10-20 weight portion, Semen Vaccariae 5-15 weight portion, Rhizoma et radix valerianae 10-20 weight portion, Cortex Albiziae 10-20 weight portion, Radix Codonopsis 10-20 weight portion, Radix Astragali 15-25 weight portion, Rhizoma Dioscoreae 15-25 weight portion, Radix Rhodiolae 5-10 weight portion, Fructus Hippophae 10-20 weight portion, Herba Micromeriae Biflorae 10-20 weight portion, Bulbus Lilii 15-25 weight portion, Radix Ophiopogonis 10-20 weight portion, Oxyria sinensis Hemsl. 10-20 weight portion, Rhizoma alpiniae pumilae 10-20 weight portion, volume stem knotweed 15-25 weight portion, Radix Oryzae Glutinosae 10-20 weight portion, Folium Fumicis Dentati 10-20 weight portion and Herba Hemisteptae Lyratae 15-25 weight portion.

In described pharmaceutical composition, the parts by weight of each raw medicinal material can also be preferably: Pericarpium Citri Reticulatae Viride 15 weight portions, Semen Litchi 16 weight portions, Rhizoma Cyperi 21 weight portions, Fructus Citri Sarcodactylis 15 weight portions, Fructus Citri 15 weight portions, Flos Rosae Rugosae 15 weight portions, FLOS MUME 13 weight portions, Semen Aesculi 17 weight portions, Herba Aristolochiae 14 weight portions, Rhizoma Corydalis Decumbentis 12 weight portions, Herba Leonuri 20 weight portions, Herba Lycopi's 19 weight portions, Caulis Spatholobi 15 weight portions, Semen Vaccariae 8 weight portions, Rhizoma et radix valerianae 15 weight portions, Cortex Albiziae 12 weight portions, Radix Codonopsis 16 weight portions, the Radix Astragali 20 weight portions, Rhizoma Dioscoreae 20 weight portions, Radix Rhodiolae 7 weight portions, Fructus Hippophae 15 weight portions, Herba Micromeriae Biflorae 15 weight portions, Bulbus Lilii 21 weight portions, Radix Ophiopogonis 15 weight portion, Oxyria sinensis Hemsl. 15 weight portions, Rhizoma alpiniae pumilae 15 weight portions, volume stem knotweed 21 weight portions, Radix Oryzae Glutinosae 15 weight portions, Folium Fumicis Dentati 15 weight portions and Herba Hemisteptae Lyratae 19 weight portions.

In order better to realize foregoing invention object, the present invention also provides a kind of preparation method that is used for the treatment of the pharmaceutical composition of caused by hepatic stagnation qi stagnation hypogalactia in puerperal, and the dosage form of described pharmaceutical composition is tablet, and described preparation method comprises the following steps:

The first step, is mixed in proportion each raw medicinal material of described Chinese medicine, adds the ethanol that the determining alcohol with respect to 4～5 times of mixture qualities is 85%～90%, and reflux 2～4 hours is extracted, and filters and obtains the first extracting solution; The medicinal residues that filter to obtain add the ethanol that the determining alcohol with respect to 2～3 times of described medicinal residues quality is 90%～95% again, and reflux 1～3 hour, extracts, and filters and obtains the second extracting solution; The first extracting solution and the second extracting solution are merged, and concentrating under reduced pressure is removed alcohol solvent, dry, obtains and gets dry extract;

Second step, the dry cream that the first step is obtained is placed in super micron mill to be pulverized 2～3 hours, pulverizes, and sieves, and obtains 300 order～400 object micropowders;

The 3rd step, the micropowders that second step is obtained, add microcrystalline Cellulose with respect to 0.1～0.3 times of its quality, 0.15～0.3 times of lactose, the starch of 0.2～0.35 times, sieve, mix homogeneously, granulate, dry, add with respect to 0.025～0.04 times of magnesium stearate of micropowders quality, granulate, tabletting, makes.

When the dosage form of described pharmaceutical composition is injection, described preparation method comprises the following steps:

The first step, described raw medicinal material is mixed in proportion, put into the mixed powder that super micron mill is ground into the micron particles of 0.1～10 μ m volume average particle size and the nano-scale particle composition that particle diameter is less than 0.1 μ m volume average particle size, the powder rate that obtains of described mixed powder is at least 95%;

Second step, in the mixed powder that the first step obtains, add the ethanol that the determining alcohol with respect to 3～5 times of the quality of described mixed powder is 85%～95%, stirring and dissolving obtains alcoholic solution, by alcoholic solution under the condition of 5 ℃～10 ℃ standing 24～36 hours, adopt percolation with the speed of 1～2ml per minute percolation slowly, collect percolate, concentrate and be dried, and at this, put into super micron mill and pulverize 40～60 minutes, obtain the mixed powder of the micron particles of 0.1～10 μ m volume average particle size and the nano-scale particle composition that particle diameter is less than 0.1 μ m volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,

The 3rd step, gets mixed powder 10g～20g that second step obtains, and adds propylene glycol 30g～50g, adds 200ml water for injection, stirs it is dissolved, and further injects water to 1000ml, then adds 1g～1.5g needle-use activated carbon, fully stirs 30～50 minutes; Decarbonization filtering; With 0.22～0.24 μ m filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.

When the dosage form of described pharmaceutical composition is liniment, described preparation method comprises the following steps:

Step 1: first described raw medicinal material is ground into coarse powder, more further pulverizes, cross 100 mesh sieves, the fine powder amount that enable pass is crossed 100 mesh sieves at least reaches 40%, and the fine powder of collecting by 100 mesh sieves obtains fine powder a;

Step 2: can not drop into multi-function extractor by the coarse powder of 100 mesh sieves and extract twice, and add for the first time weight portion 8-10 times of water gaging and decoct 1-3 hour, and add for the second time weight portion 6-10 times of water gaging and decoct 1-3 hour, and merge twice decocting liquid, and filter to get filtrate; The heating of gained filtrate is concentrated into pasty state, puts into after 80 ℃ of oven dry of baking oven, room temperature is cooling, grinds to form fine powder b;

Step 3: call in glycerol after fine powder a is mixed with fine powder b and make liniment.

The invention has the beneficial effects as follows: pharmaceutical composition of the present invention, utilize the traditional theory of Chinese medical science of China, take dispersing the stagnated live-QI to relieve the stagnation of QI, active lactogenesis as main, cure mainly caused by hepatic stagnation qi stagnation hypogalactia in puerperal, have rapid-action, determined curative effect, safe, have no side effect and be difficult for the advantage of recurrence.

The specific embodiment

The invention provides a kind of pharmaceutical composition that is used for the treatment of caused by hepatic stagnation qi stagnation hypogalactia in puerperal, wherein, comprise following raw medicinal material: Pericarpium Citri Reticulatae Viride, Semen Litchi, Rhizoma Cyperi, Fructus Citri Sarcodactylis, Fructus Citri, Flos Rosae Rugosae, FLOS MUME, Semen Aesculi, Herba Aristolochiae, Rhizoma Corydalis Decumbentis, Herba Leonuri, Herba Lycopi, Caulis Spatholobi, Semen Vaccariae, Rhizoma et radix valerianae, Cortex Albiziae, Radix Codonopsis, the Radix Astragali, Rhizoma Dioscoreae, Radix Rhodiolae, Fructus Hippophae, Herba Micromeriae Biflorae, Bulbus Lilii, Radix Ophiopogonis and Oxyria sinensis Hemsl.; Preferably, described pharmaceutical composition also comprises: Rhizoma alpiniae pumilae, volume stem knotweed, Radix Oryzae Glutinosae, Folium Fumicis Dentati and Herba Hemisteptae Lyratae.

The pharmacological property of above-mentioned raw materials medical material is as follows:

Pericarpium Citri Reticulatae Viride: nature and flavor toil, temperature.Enter liver, gallbladder, stomach warp.Can soothing the liver dispelling the stagnated QI, removing food stagnancyization is stagnant.For costa sternales gastral cavity distending pain, acute mastitis, colic, stagnation of QI due to dyspepsia.Modern pharmacology experimentation shows: Pericarpium Citri Reticulatae Viride injection can reduce the tonic contraction of in vitro Guinea pig Gastric, intestinal, gallbladder and Mouse Uterus, and makes smooth muscle of bladder excited.The gallbladder contraction that guinea pig in vitro stomach, intestinal and the rabbit that acetylcholine is caused causes at body pipe smooth muscle and carbachol, has significant spasmolysis.The rabbit that the guinea pig in vitro intestinal that histamine is caused and physostigmine salicylate cause, in body intestinal tonic contraction, has significant inhibitory action.Can resist the Mouse Uterus tonic contraction that pituitrin causes.Hormesis to Cavia porcellus at body bladder and Rabbit thoracic aorta, mainly by excited adrenergic α receptor, and to aortal excitation than norepinephrine a little less than.The perfusion flow minimizing that significantly Eff ect in Guinea Pigs lung causes because of histamine, and can remove the spasm effect of histamine to bronchus chain.Also can significantly increase the bile flow of rat, and biliary tract tension force is increased.

Semen Litchi: sweet, puckery, temperature.Return liver, stomach warp.< < Bencao Beiyao > >: " enter Liver and kidney, loose stagnant gas, wards off cold-evil, controls gastric abscess, married woman's vim and vigour pain." < < Compendium of Materia Medica > >: " the loose stagnant gas of row, controls swelling of the scrotum pain due to disorder of QI, married woman's vim and vigour pain." cold-dispelling pain-relieving, promoting QI to circulate and dispersing the agglomeration of the pathogens.For colic of cold type pain due to disorder of QI, painful and swollen testis, heart peratodynia, hernia, the long-pending stomachache of the women's Qi stagnation stasis of blood.The mouse subcutaneous injection (60-400mg/kg) of giving hungry 22 hours by this thing, can make blood glucose decline, and liver glycogen content also significantly reduces.

Rhizoma Cyperi: the pungent micro-hardship of nature and flavor is sweet, flat.Enter liver, tri-jiao channel.< < Compendium of Materia Medica > > says: " gas of Rhizoma Cyperi is flat and cold, fragrant and can alter, and its taste is how pungent can fall apart, and micro-hardship can be fallen, micro-sweet energy with ".< < Amplification on Materia Medica addendum > >: " Rhizoma Cyperi, must soak with urine of baby boys, and all vim and vigour medicines must cause edema caused by disorder of QI and hemopoietic with it, and the justice of this Yin grows while yang is generating also." resolving depression of can regulating the flow of vital energy; Menstruction regulating and pain relieving; Antiabortive.Main distending pain over the hypochondrium; Mammary swelling is educated; Hernia pain; Menoxenia; Gastral cavity abdomen feeling of fullness pain; Belch acid regurgitation, vomiting and nausea; Abdominal pain during menstruation; Bleeding not during menses; Frequent fetal movement.For stagnation of QI due to depression of the liver, breast, the side of body, abdominal distention, dyspepsia, breast gastral cavity painful abdominal mass is vexed, colic of cold type stomachache, distending pain of the breast, menoxenia, amenorrhea dysmenorrhea.Ethanol extraction does not affect epinephrine and the effect of acetylcholine to blood pressure, but can partly block the effect of histamine.The isolated uterine of 5% Rhizoma Cyperi fluid extract to animals such as Cavia porcellus, rabbit, cat and dogs, no matter oneself pregnant or unpregnancy, has inhibitory action, makes that its contractility weakens, muscular tension reduces.

Fructus Citri Sarcodactylis: pungent, bitter, sour, temperature; Return liver, spleen, lung meridian.< < the southern regions of the Yunnan Province book on Chinese herbal medicine > >: " tonifying liver warming the stomach, preventing or arresting vomiting is told, and the Fructus Citri Sarcodactylis cold syndrome of the stomach expectorant that disappears, controls gastric qi pain, the only cold pain of face, and middle circulation of qi promoting." < < book on Chinese herbal medicine new > > again: " control gas soothing liver-QI, stomach function regulating reduces phlegm, and removing mass is controlled dysphagia and regurgitation, eliminating mass abdominal mass scrofula." liver-smoothing, qi-regulating, and stomach and alleviating pain.For stagnation of liver-QI and stomach-QI, distending pain in the chest and hypochondrium, gastral cavilty feeling of fullness, lack of appetite vomiting.The contained Limettin of this product shrinks guinea-pig isolated trachea due to histamine, has antagonism; Isolated ileum segments in guinea pigs and isolated tracheal test in Ovum Gallus domesticus album sensitization show to have certain antiallergic activity.This product ethanol extract has obvious inhibitory action to rat, rabbits infestines, and intravenous administration also has same inhibitory action to anesthetized cat, rabbit at body intestinal tube.Fructus Citri Sarcodactylis ethanol extract can significantly increase the coronary flow of guinea pig isolated heart and improve the hypoxia-bearing capability of mice; Rat is had to protective effect because of the myocardial ischemia that pituitrin causes.

Fructus Citri: acrid in the mouth, sweet is nontoxic.< < explaining abstruseness of the canon of materia medica > >: " gas of the reason part of the body cavity above the diaphragm housing the heart and lungs, preventing or arresting vomiting is contrary, feed, spleen invigorating." < < book on Chinese herbal medicine new > > again: " diuretic that stimulates the menstrual flow, controls waist beriberi for suppressing the hyperactive liver Shu Yu, reason lung qi." function depressed liver-energy dispersing and QI regulating, the chest stuffiness relieving reduces phlegm, dehumidifying and in.Cure mainly the therapeutic method to keep the adverse QI flowing downwards, except mind expectorant water.Boil wine and drink, control mental disorder cough.Decoct water, control pain due to disorder of QI under the heart.Root leaf is skin-deep same.These product are pungent can manage it loose, and the catharsis of bitter energy enters Liver Channel and can unclog and readjust irritability and pain relieving.The strongly fragrant distending pain in the chest and hypochondrium for the treatment of the liver, gas perfume (or spice) is amusing, and pungent row hardship is let out, and enters taste with promoting the circulation of QI to alleviate the stagnation in middle-JIAO.With the abdominal distention of controlling stagnation of QI in spleen and stomach, bitter dry the falling of these product let out with preventing phlegm from forming and stopping coughing, and pungent row enters lung and the chest stuffiness relieving of regulating the flow of vital energy.With controlling abundant expectoration, cough, uncomfortable in chest etc.The contained hesperidin of these product to Cavia porcellus for want of vitamin C and the eyes bulbar conjunctiva blood vessel inner cell cohesion that causes and capillary resistance reduce and be improved effect, can reduce the cohesion of horse blood cell.Hesperidin has prevention cold injury and suppresses the aldehyde reductase effect of rat lens.Obacunone has the effect that strengthens isolated rabbit intestinal tension force and amplitude.

Flos Rosae Rugosae: warm in nature, sweet and slightly bitter taste, returns liver spleen channel.< < A Supplement to the Compendium of Materia Medica > >: " and blood, promoting the circulation of blood, regulates the flow of vital energy.Control migratory arthralgia." < < book on Chinese herbal medicine new > > again: " the strongly fragrant gas of soothing liver-QI gallbladder, spleen invigorating pathogenic fire reducing.Control cold type of pain in abdomen, gastral cavilty is long-pending cold, and holding concurrently can removing blood stasis." promoting the circulation of QI, promoting the circulation of blood, control migratory arthralgia, loose tired pain relieving.Flos Rosae Rugosae and Herb have convergence, can be used for woman in menstrual period too much, and leucorrhea with red and white discharge and enteritis, dysentery, the red half of intestinal are hemorrhage etc.Regulate the flow of vital energy resolving depression and blood dissipating blood stasis.Cure mainly stomachache due to hyperactive liver-QI attacking the stomach, new lingering pathogenic wind numbness, the spitting of blood of spitting blood, menoxenia, leucorrhea with red and white discharge, dysentery, acute mastitis, toxic swelling.In Flos Rosae Rugosae, contain 300 various chemical components, as fragrant alcohol, aldehyde, fatty acid, phenol with containing oil and the fat of essence, often eat in Flos Rosae Rugosae goods with the easing the affected liver stomach of waking up, have a respite and invigorate blood circulation, looks improving and the skin nourishing, makes us refreshing refreshing.

FLOS MUME: sour and astringent, flat.Return liver, stomach, lung meridian.< < A Supplement to the Compendium of Materia Medica > >: " < < all sorts of flowers mirror > >: powder for improving appetite is evil; the food of cooking congee; help the gas of sun clearly to rise; distillation point tea; promoting the production of body fluid to quench thirst, expelling summer-heat is washed tired." soothing liver-QI, stomach function regulating, reduces phlegm.Control globus hystericus, stomachache due to hyperactive liver-QI attacking the stomach, inappetence, dizziness, scrofula.Stomachache due to hyperactive liver-QI attacking the stomach.The circulation of qi promoting of this product fragrance enters liver stomach, and energy dispersing the stagnated live-QI to relieve the stagnation of QI, is amusing, regulating the flow of Qi and the middle Jiao.The distending pain over the hypochondrium for the treatment of stagnation of liver-QI and stomach-QI, gastral cavity abdomen feeling of fullness, belch is indigestion and loss of appetite etc., can with the compatibility such as Radix Bupleuri, Fructus Citri Sarcodactylis, Rhizoma Cyperi.Globus hystericus.The circulation of qi promoting of this product fragrance, dissipating phlegm and resolving masses.

Semen Aesculi: warm in nature, sweet in the mouth.Return liver, stomach warp.Regulating the flow of QI to ease the stomach, and stomach and alleviating pain., gastralgia vexed for breast abdominal distention.This product is can dispersing the stagnated live-QI to relieve the stagnation of QI stagnant with row, again can regulating the flow of QI to ease the stomach with stomach function regulating.The cards such as hypochondriac pain uncomfortable in chest, abdominal distention for the treatment of stagnation of liver-QI and stomach-QI, the compatibilities such as normal and Fructus Akebiae, Fructus Citri Sarcodactylis; If control premenstrual distending pain of the breast, can be equal to use with Fructus Liquidambaris, Rhizoma Cyperi, Radix Curcumae.The cerebral edema that Aescin causes tin triethyl sulfate (Trietyistannous-sulfate) has protective effect, and leaf Saponin can suppress the edema that rat causes due to heat injury.The total Saponin of Semen Aesculi through different dosing by way of all thering is the effect of anti-chmice acute hypobaric hypoxia.

Herba Aristolochiae: hardship, temperature; Enter liver,spleen,kidney warp.< < Bencao Tujing > >: " Xie Fenglao.The Herba Ephedrae cold diaphoresis that cures the wound, with Radix Et Rhizoma Rhei with clothes induced abortion gas." < < book on Chinese herbal medicine is new > > again: " removing heat from blood and promoting blood circulation, removes wind dampness removing, walks meridians, the double swollen pain of waist lower limb of controlling." circulation of qi promoting removing dampness, promoting blood circulation and stopping pain.Treat for stomachache, colicky, edema during pregnancy, puerperal, vim and vigour were suffered from abdominal pain, rheumatalgia.Promoting flow of QI and blood, pain relieving, diuresis.Edema during pregnancy, breast stomachache, colic, rheumatalgia.Herba Aristolochiae, gas is invigorated blood circulation, and controls the medicine of all pains also.The gas of the person, suitable peaceful, contrary pain vexed work.As > > Herba Aristolochiae in the Young < < side of directing at is controlled the brachialgia of expectorant note, gas stays colic, abdominal mass is poly-, renal mass stomachache, and puerperal, vim and vigour were suffered from abdominal pain, he is as edema during pregnancy, edema over the face tachypnea, man's wind labor, chronic cough is not healed, know with this medicine and control it, the peace of invariably getting into bed.Therefore Gai Weiqi is good at popular vim and vigour also.See book and discuss and cure mainly, only belong to the diseases such as pregnant edema during pregnancy, stomachache, wind consumptive disease, in his disease not and here.Be its reason of controlling, also only because bitter in the mouth master is in catharsis, warm in nature being led to lives, thus the passage of invigorating blood circulation, and make water without unfavorable, and wind removes invariably, and blood is lived invariably, therefore pain is all controlled also invariably with swollen.

Rhizoma Corydalis Decumbentis: bitter, micro-pungent, temperature.Return Liver Channel.< < whole nation Chinese herbal medicine compilation > >: " wind-damp dispelling, blood pressure lowering.Cure mainly rheumatic arthritis, lumbar muscle strain, hypertension, cerebrovascular accident causes hemiplegia." function promoting blood circulation to remove obstruction in the collateral, promoting the circulation of QI to relieve pain.For apoplectic hemiplegia, injury from falling down, rheumatic arthritis, sciatica.Rhizoma Corydalis Decumbentis alkaloid can make anesthetized dog brain and lower extremity blood flow amount increase, and vascular resistance lowers (all there were significant differences to learn by statistics processing), and blood pressure slightly declines, and points out it to have the effect of expansion of cerebral vascular and lower limb vascular.1% summer is large to add in 15ml smooth muscle solution intestinal tube rhythmicity to shrink without injection 0.3ml to strengthen, and tension force strengthens, or even spastic contraction, and prompting has excitation to rat isolated smooth muscle.For sciatica, rheumatic arthritis, fracture and sprain, poliomyelitis etc., have pain relieving, detumescence, alleviates ankylosis, promotes suffering limb functional rehabilitation, accelerating union of bone fracture texts.

Herba Leonuri: bitter in the mouth, pungent, cold nature, enters liver, pericardium channel, < < Tang materia medica > >: " apply fourth swollen, take juice and make fourth toxic swelling internal diabetes; Descend again dead fetus in the uterus, feeling of distension and oppression after main product; All assorted poison are swollen, and red trip etc. are swollen; Extracting juice drips in ear as bean, main Ting ear; Middle a poisonous snake mentioned in ancient books snake venom, applies it." there is promoting blood flow to regulate menstruation, inducing diuresis to remove edema, the effect of heat-clearing and toxic substances removing, for the menoxenia due to blood stasis, dysmenorrhea, amenorrhea, puerperal abdonimal pain or lochiorrhea, edema, dysuria, traumatic injury, the cards such as sore and toxic.Effective ingredient is Herba Leonuri element (Leonurin), for oral administration can distending the blood vessels and make blood pressure drops, and there is an adrenolytic effect of a word used in person's names, can control arteriosclerotic and neuropathic hypertension, can increase the frequency of uterus movement again, for promoting uterotonic puerperal, and long-term metrorrhagia is caused languisher effectively, leonurine solution has curariform action mask to frog neuromuscular specimen; To have diuresis to anesthetized rabbit intravenous injection, during high concentration, can cause haemolysis. to Canis familiaris L. ischemic-type initial phase, acute renal failure has remarkable therapeutic effect to Herba Leonuri.

Herba Lycopi: bitter, pungent, tepor; Return liver, spleen channel.Effect blood circulation promoting and blood stasis dispelling, inducing diuresis to remove edema.Cure mainly blood stasis amenorrhea, stimulate the menstrual flow, lump in the abdomen, the stagnant stomachache of the stasis of blood in puerperal, body and face edema, injury from falling down, incised wound, sore and toxic, edema, ascites (edema of congestion retardance, the mutual resistance of the water stasis of blood is especially suitable).Containing volatile oil, glycoside, tannin and resin; Also contain flavonoid, phenols. aminoacid, organic acid, Saponin, various saccharides.

Caulis Spatholobi: nature and flavor are bitter, sweet, temperature.Return liver, kidney channel.Can relaxing muscles and tendons to promote blood circulation; Nourishing blood for regulating menstruation.Main numb hand and foot; Quadriplegia; Rheumatic arthralgia; Women has through uncomfortable; Dysmenorrhea; Amenorrhea.Function: enrich blood, invigorate blood circulation, dredging collateral.For menoxenia, blood deficiency and yellow complexion, paralysis and numbness, rheumatic arthralgia.This product is containing formoononetin, ononin, prunusetin., A Fuluomoxin, cajinin, licochalcone, isoliquiritigenin, tetrahydroxy chalcone derivative, Daidezin, 7-hydroxy-11,12-(methylenedioxy)coumestan, 9-O-methoxyl group coumestrol, 3,7-dihydroxy-6-melonia flavonol, epicatechin, protocatechuic acid, freidelin-3b-alcohol, b-sitosterol, daucosterol and 7-ketone group-b-sitosterol.Pharmacological action: the effect to hemopoietic system; Effect to blood coagulation, fibrinolytic; Suppress heart and the effect of reducing blood pressure; Antitumaous effect; Adjusting to lipid metabolism.

Semen Vaccariae: hardship, flat; Return liver, stomach warp.The newly organized > > of < < book on Chinese herbal medicine: " Semen Vaccariae, its property is very anxious, descending and do not go up passerby also.All diseases are contrary and upper punch person uses can fall, thus can rely on to make it as minister with also.But its property is overrun, should should not for a long time, can not know again temporarily yet.Or ask: Semen Vaccariae can stimulating milk secretion, be also can be up thing also.Do not know breast not descend and purgation is descending after all, but not also up.Upper Jiao has can descend person, all can descend logical, non-only row in the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels and not all right in the part of the body cavity above the diaphragm housing the heart and lungs also." can promoting the circulation of blood regulating menstruation, reducing swelling and alleviating pain, the lactogenesis of invigorating blood circulation, expedite the emergence of stimulating milk secretion, thymus dredging in puerperal.For blood stasis amenorrhea, dysmenorrhea, difficult labour; Lack of lactation after delivery, acute mastitis swells and ache; Pyretic stranguria, stranguria with blood, stranguria caused by urinary stone.Semen Vaccariae has antiearly pregnancy, and Antiimplantation Action also has regulation of physiological functions, affects the effect of internal metabolism.Also have report to think, Semen Vaccariae decoct has contraction to Isolated Rat Uterus; Its ethanol extract effect is especially strong.

Rhizoma et radix valerianae: pungent, sweet, warm; GUIXIN, Liver Channel.< < Traditional Chinese Medicine in Sichuan will > >: " control cranial nerve and the heart, stomach is weak, chronic off one's dot and urine collapse." control irritability, a little less than stomach, lumbago, menoxenia, traumatic injury.Apply its effect of calming the nerves and can be used for treating the diseases such as malaise, cardiopalmus dreaminess, can with the compatibilities such as Semen Ziziphi Spinosae, Cortex Albiziae, Caulis Polygoni Multiflori; Another and Radix Salviae Miltiorrhizae, Herba Leonuri, Herba Lycopi, the same use of Flos Carthami, can be used to treat the disease of abdominal pain in menstruation, soreness of the waist and knees, bone fracture and injury.Rhizoma et radix valerianae has quelling effect to central nervous system, when excited, can stabilize nerve, can help to refresh when fatigue.Contained Rhizoma et radix valerianae epoxy three esters of Rhizoma et radix valerianae root can help to alleviate spasm and pain, contribute to relax neuropathic dyspepsia, stomach spasm or enteritis.Total alkaloids in Rhizoma et radix valerianae has antibacterial action, especially can resist the infection that gram-positive bacterium is caused.The pink flower Rhizoma et radix valerianae of Rhizoma et radix valerianae can relieving insomnia, sleep disorder, flurried, anxiety neurosis and other imbalance diseases, also can relax one's muscles simultaneously, makes interior environment oil recover stable state.

Cortex Albiziae: sweet, flat; Enter the heart, Liver Channel.< < Japan hanako materia medica > >: " soft extracts, subduing inflammation reuniting the fractured tendons and bones." < < Sheng Nong's herbal classic > >: " Herba Albiziae, sweet in the mouth is flat.Main settling five organs, sharp will, makes us happy carefree ... raw mountain valley." administration of antiallergic Cortex Albiziae decoct rat oral gavage can suppress its peritoneum mast cell degranulation, in vitro tests also has similar effect.Cortex Albiziae decoct can obviously suppress antigen (horse serum) to the sensitization process of rat and antibody production process.Cortex Albiziae is the bark of leguminous plant Herba Albiziae, and Cortex Albiziae another name closes confused skin, night platform skin, Herba Albiziae veneer, and Cortex Albiziae has the resolving depression of calming the nerves, the effect of the eliminating carbuncle of invigorating blood circulation, and Cortex Albiziae has the effect for the treatment of irritability, melancholy, sleeplessness, inside and outside carbuncle and ulcer, traumatic injury.

Radix Codonopsis: property is flat, sweet in the mouth, micro-acid; Return spleen, lung meridian.Invigorating the spleen and replenishing QI, spleen invigorating lung benefiting.For deficiency of the spleen and lung, the cardiopalmus of breathing hard, anorexia and loose stool, dyspnea due to deficiency cough, interior-heat is quenched one's thirst.These product are clinical conventional Qi-tonifying drug, function invigorating the spleen to benefit the lung, effect person of modern times ginseng and for a little less than, be applicable to various deficiency of vital energy deficiency persons.Contained saponin, inulin, Alkaloid, starch etc. have strong effect in various degree to the many internal organs of human body, can improve the adaptability of human body.There is antiulcer, can increase intestinal tension force, regulate stomach motion, in the intestines and stomach coordinating preparation, reuse the intestines and stomach regulation of mental activities agent of Radix Codonopsis to chronic diarrhea, ulcerative colitis, antral gastritis, chronic atrophic gastritis etc. quite have effect.In addition, these product are the eliminating evil medicine compatibility such as normal and diaphoretic medicine, cathartic drug also, for deficiency of vital energy diseases caused by exogenous pathogenic factor or interior-excess accumulation of heat and the weakened body resistance card of the dominations of pathogen such as deficiency of qi and blood, with strengthening vital QI to eliminate pathogenic factors, makes to attack heresy and healthy energy is not hindered.

The Radix Astragali: sweet, tepor; Return lung, spleen, liver, kidney channel.< < Bencao Beiyao > >: " lossless can sending out, has antiperspirant to stop for the Radix Astragali, life consolidating superficial resistance; Process with invigorating middle warmer beneficial vigour, strong taste.Hemopoietic, granulation promoting, evacuation of pus expelling the toxic substance from the body with tonic, carbuncle sore panacea.Variola does not rise, and yang deficiency should it without hot person." the just > > of < < book on Chinese herbal medicine: " and the Radix Astragali, soil in tonification, replenishing vital QI with drugs of warm nature taste, all middle gas is depressed, and spleen soil is weak, and sagging person is the most suitable for clearing heat in QI system.The through people's of its skin skin table muscle, solid protection is defended sun, enriches table minute, is its speciality, thus all diseases of exterior deficiency, the most refreshing agent." function consolidating superficial resistance arresting sweating, inducing diuresis to remove edema, the evacuation of pus of holder skin ulcer, regulating fluid apssage.The Radix Astragali strengthens heart contraction ability, can improve the blood circulation of whole body, can coronary artery dilator, kidney blood vessel and Rhizoma Bistortae peripheral vessel, make cutaneous circulation vigorous; Can improve the nonspecific immunity power of body, protect the liver and fall hypoglycemic effect, staphylococcus, blood dissolubility streptococcus, Diplococcus pneumoniae, dysentery bacterium etc. are had to inhibitory action.The Radix Astragali can appreciable impact splenocyte Information Conduction, realizes immunoregulation effect.Can be used for hypertension, ischemic heart desease, acute glomerulonephritis, gastric ulcer, psoriasis, diabetes, osteoporosis.< < Bencao Jingshu > >: " the real table of function, person does not use pathogenic factor in the exterior; Can help gas, QI excess person does not use; Can interiorly fill in, tonifying for the deficiency, chest and diaphragm is gas-tight asks, the intestines and stomach has stagnant person not use; Energy YANG invigorating, overabundance of YANG leading to deficiency of YIN person avoids it; Part of the body cavity above the diaphragm housing the heart and lungs intenseness of heat, part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels deficiency and coldness person avoids it; The many anger of patient, disharmony in liver-QI person do not take; Variola blood system heat is person's forbidding very.”

Rhizoma Dioscoreae: sweet in the mouth, property is put down, enter lung, spleen, kidney channel, there is strengthening the spleen and tonifying the lung, stomach reinforcing the kidney invigorating, the benefit of reinforcing the kidney essence, hearing-improing and eyesight improving, help that the five internal organs, bone and muscle strengthening, long will are calmed the nerves, the effect of life lengthening, cure mainly that weakness of the spleen and stomach, lassitude, inappetence, chronic diarrhea and dysentery, insufficiency of lung-QI are dry, phlegm dyspnea cough, kidney qi loss, soreness of the waist and knees, lower limb flaccidity are weak, the red card such as swollen, fat of the frequent micturition of quenching one's thirst, the premature ejaculation of passing out semen, leukorrhagia nebulousurine, skin.Rhizoma Dioscoreae (parched with bran) spleen reinforcing stomach invigorating.For insufficiency of the spleen lack of appetite, the loose stool of having loose bowels, leukorrhagia.This product yin nourishing can help wet, so wet, contain fullness in the epigastrium and abdomen or have stagnant, person is unsuitable excess pathogen.Need to remind everybody, edible Rhizoma Dioscoreae is general without obvious contraindication, but because it has astriction, so catch a cold, constipation due to dry stool person and the stagnant person of the intestines and stomach avoid use.

Radix Rhodiolae: sweet, hardship, flat; Return lung, heart channel.Radix Rhodiolae is dry root and the rhizome of crassulaceae plants Radix Rhodiolae, and the effect of Radix Rhodiolae and effect are energy the kidney invigorating, regulate the flow of vital energy and nourish blood, and have promoting blood circulation and hemostasis, clearing away lung-heat to relieve cough, antipyretic, and the effect under leukorrhagia stopping, and the side effect of Radix Rhodiolae is not temporarily found.Radix Rhodiolae can improve sleep, blood-enriching and blood-promoting circulation, anti-cerebral anoxia, resisting fatigue, promoting blood circulation and hemostasis, clearing away lung-heat to relieve cough, change become silted up detumescence, antipyreticly bring down a fever, nourish the effects such as vigour; Be used for the treatment of traumatic injury and burn and scald outward.Research points out that Oxidation, in a lot of advancing of disease processes, playing the part of very important role, such as cancer, cardiovascular diseases, diabetes, nerve degeneration and rheumatoid arthritis etc.In traditional medicine, Radix Rhodiolae is also for treating diabetes.Relevant experiment utilizes mouse to make object, and test Radix Rhodiolae is to controlling glycemic index, ferment and the activity of some antioxidative of type-II diabetes.

Fructus Hippophae: Fructus Hippophae and oil have very high medical value, can reduce cholesterol, allevating angina pectoris outbreak, prevents and treats the effect of coronary atherosclerotic heart disease in addition; Have and eliminate the phlegm, cough-relieving, relieving asthma and treat the effect of chronic tracheitis; Can treat gastric duodenal ulcer and dyspepsia etc., evident in efficacy to diseases such as chronic superficial gastritis, atrophic gastritis, colitis; Burn, scald, cutter burning, cold injury are had to good therapeutical effect; Cervical erosion is had to good therapeutic effect.In sea buckthorn fruit, contain 7 kinds of Endospermum chinense Benth. materials such as isorhamnetin and glucoside thereof, Quercetin, nimbecetin, the usefulness that has cough-relieving, relievings asthma and eliminate the phlegm, expand coronary vasodilator, reduce cholesterol, is usually used in treating ischemic heart desease, and treatment angina pectoris effective percentage is reached to 94%.In Fructus Hippophae, SOD active component is abundant, and every gram of sea-buchthorn fresh fruit SOD content reaches 2746.0 enzyme units, and its content is 4 times of Radix Ginseng.It can block the free radical producing because of substance in vivo peroxidating, and the generation of this free radical and human senility, disease is closely related.

Herba Micromeriae Biflorae: pungent, temperature.Function cures mainly: expelling pathogenic wind from the body surface, warming middle-JIAO dehumidifying.For cold cough, stomachache, acute gastroenteritis, dyspepsia, abdominal distention, stomachache, colicky, prevention dysentery.

Bulbus Lilii: Bulbus Lilii is except containing protein 21.29%, fat 12.43%, reducing sugar 11.47%, starch 1.61%, and calcium, phosphorus, ferrum, every hectogram are containing outside the nutrients such as 1.443 milligrams of vitamin Bs, 21.2 milligrams of vitamin Cs, also contain some special nutritional labelings, as multiple alkaloids such as colchicine.These composition comprehensive functions, in human body, not only have the merit of good nutritious tonifying, but also multiple Seasonal diseases dry in autumn and that cause is had to certain preventive and therapeutic effect.In the traditional Chinese medical science, say that fresh Bulbus Lilii has tranquilizing by nourishing the heart, the effect of nourishing the lung to arrest cough, is highly profitable to weakling after being ill.

Radix Ophiopogonis: sweet, the micro-hardship of property, is slightly cold; GUIXIN, lung, stomach warp.Have YIN nourishing and the production of body fluid promoting, the effect that lung moistening clears away heart-fire, can be used for sore throat pharyngalgia, and Tianjin wound is thirsty, and interior-heat is quenched one's thirst, vexed insomnia, dryness of the intestine constipation etc.Clear the moon of supporting lung stomach goes heart use more, the YIN nourishing use that connects with the heart that clears away heart-fire more.These product are sweet cold clear and rich, are apt to control deficiency of stomach-Yin, and dry tongue is thirsty, the indigestion and loss of appetite not hungry card that waits.In addition the available deficiency of YIN dryness of the intestine of controlling also, constipation person.Modern study shows, can improve immunologic function Radix Ophiopogonis, various bacteria is had inhibitory action, can strengthen pituitary adrenal system function, improves organism adaptation ability.Join Radix Adenophorae (Radix Glehniae) Radix Ophiopogonis, lung stomach is ruled together, and has the cool stomach of lung heat clearing, and the good effectiveness of YIN nourishing and the production of body fluid promoting is lacked expectorant, the diseases such as dry laryngopharynx for the dry cough due to lung-dryness syndrome due to deficiency of YIN or thermal burn lung yin.Medication is noted: all Deficiency and coldness of spleen and stomach are had loose bowels, and stomach has phlegm retention turbid damp and cruelly feels cough due to wind and cold person and all avoid and take Radix Ophiopogonis.

Oxyria sinensis Hemsl.: light, cool.Function cures mainly: moistening the lung and resolving phlegm.Cure mainly pulmonary tuberculosis, cough due to lung-heat.

Rhizoma alpiniae pumilae: pungent, temperature.Function cures mainly: relieving cough and asthma, dispersing cold for relieving pain, except rheumatism, separates sore.For wind and cold cough with asthma, peratodynia, Fengshi Guanjie pain, falls and damages blood stasis stagnation, menoxenia, innominate toxic swelling.

Volume stem knotweed: pungent; Warm in nature.Function cures mainly: strengthening the spleen to promote digestion.Main dyspepsia; Diarrhoea.

Radix Oryzae Glutinosae: sweet, flat.Function cures mainly: yin nourishing, hidroschesis, stomach invigorating.For spontaneous perspiration, night sweat, hepatitis.

Folium Fumicis Dentati: hardship; Cold in nature.There is heat-clearing and toxic substances removing; The effect of killing parasites for relieving itching, cures mainly acute mastitis; Sore swollen toxin; Scabies.

Herba Hemisteptae Lyratae: pungent, flat.Function cures mainly: dispersing swelling and dissipating binds, heat-clearing and toxic substances removing.For mastitis, cervical lymphadenitis, carbuncle furuncle, rubella pruritus.

In described pharmaceutical composition, the parts by weight of each raw medicinal material can be preferably again: Pericarpium Citri Reticulatae Viride 10-20 weight portion, Semen Litchi 10-20 weight portion, Rhizoma Cyperi 15-25 weight portion, Fructus Citri Sarcodactylis 10-20 weight portion, Fructus Citri 10-20 weight portion, Flos Rosae Rugosae 10-20 weight portion, FLOS MUME 10-20 weight portion, Semen Aesculi 15-25 weight portion, Herba Aristolochiae 10-20 weight portion, Rhizoma Corydalis Decumbentis 10-15 weight portion, Herba Leonuri 15-25 weight portion, Herba Lycopi 15-25 weight portion, Caulis Spatholobi 10-20 weight portion, Semen Vaccariae 5-15 weight portion, Rhizoma et radix valerianae 10-20 weight portion, Cortex Albiziae 10-20 weight portion, Radix Codonopsis 10-20 weight portion, Radix Astragali 15-25 weight portion, Rhizoma Dioscoreae 15-25 weight portion, Radix Rhodiolae 5-10 weight portion, Fructus Hippophae 10-20 weight portion, Herba Micromeriae Biflorae 10-20 weight portion, Bulbus Lilii 15-25 weight portion, Radix Ophiopogonis 10-20 weight portion, Oxyria sinensis Hemsl. 10-20 weight portion, Rhizoma alpiniae pumilae 10-20 weight portion, volume stem knotweed 15-25 weight portion, Radix Oryzae Glutinosae 10-20 weight portion, Folium Fumicis Dentati 10-20 weight portion and Herba Hemisteptae Lyratae 15-25 weight portion.

When the dosage form of pharmaceutical composition is tablet, described preparation method comprises the following steps:

When the dosage form of pharmaceutical composition is injection, described preparation method comprises the following steps:

When the dosage form of pharmaceutical composition is liniment, described preparation method comprises the following steps:

Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure of reaching technique effect can fully understand and implement according to this.

Embodiment 1 tablet

The embodiment of the present invention provides a kind of pharmaceutical composition that is used for the treatment of caused by hepatic stagnation qi stagnation hypogalactia in puerperal, the parts by weight of its each raw medicinal material are: Pericarpium Citri Reticulatae Viride 15 weight portions, Semen Litchi 16 weight portions, Rhizoma Cyperi 21 weight portions, Fructus Citri Sarcodactylis 15 weight portions, Fructus Citri 15 weight portions, Flos Rosae Rugosae 15 weight portions, FLOS MUME 13 weight portions, Semen Aesculi 17 weight portions, Herba Aristolochiae 14 weight portions, Rhizoma Corydalis Decumbentis 12 weight portions, Herba Leonuri 20 weight portions, Herba Lycopi's 19 weight portions, Caulis Spatholobi 15 weight portions, Semen Vaccariae 8 weight portions, Rhizoma et radix valerianae 15 weight portions, Cortex Albiziae 12 weight portions, Radix Codonopsis 16 weight portions, the Radix Astragali 20 weight portions, Rhizoma Dioscoreae 20 weight portions, Radix Rhodiolae 7 weight portions, Fructus Hippophae 15 weight portions, Herba Micromeriae Biflorae 15 weight portions, Bulbus Lilii 21 weight portions, Radix Ophiopogonis 15 weight portion and Oxyria sinensis Hemsl. 15 weight portions.

Its preparation method comprises the following steps:

The first step, is mixed in proportion each raw medicinal material of described Chinese medicine, adds the ethanol that the determining alcohol with respect to 4 times of mixture qualities is 85%, and reflux 3 hours is extracted, and filters and obtains the first extracting solution; The medicinal residues that filter to obtain add the ethanol that the determining alcohol with respect to 2 times of described medicinal residues quality is 90% again, and reflux 2 hours, extracts, and filters and obtains the second extracting solution; The first extracting solution and the second extracting solution are merged, and concentrating under reduced pressure is removed alcohol solvent, dry, obtains and gets dry extract;

Second step, the dry cream that the first step is obtained is placed in super micron mill to be pulverized 2.5 hours, pulverizes, and sieves, and obtains 350 object micropowders;

The 3rd step, the micropowders that second step is obtained, adds microcrystalline Cellulose with respect to 0.2 times of its quality, 0.2 times of lactose, the starch of 0.25 times, sieves, mix homogeneously, granulates, dry, adds with respect to 0.03 times of magnesium stearate of micropowders quality, granulate, tabletting, makes.

Embodiment 2 injections

The embodiment of the present invention provides a kind of pharmaceutical composition that is used for the treatment of caused by hepatic stagnation qi stagnation hypogalactia in puerperal, the parts by weight of its each raw medicinal material are: Pericarpium Citri Reticulatae Viride 15 weight portions, Semen Litchi 16 weight portions, Rhizoma Cyperi 21 weight portions, Fructus Citri Sarcodactylis 15 weight portions, Fructus Citri 15 weight portions, Flos Rosae Rugosae 15 weight portions, FLOS MUME 13 weight portions, Semen Aesculi 17 weight portions, Herba Aristolochiae 14 weight portions, Rhizoma Corydalis Decumbentis 12 weight portions, Herba Leonuri 20 weight portions, Herba Lycopi's 19 weight portions, Caulis Spatholobi 15 weight portions, Semen Vaccariae 8 weight portions, Rhizoma et radix valerianae 15 weight portions, Cortex Albiziae 12 weight portions, Radix Codonopsis 16 weight portions, the Radix Astragali 20 weight portions, Rhizoma Dioscoreae 20 weight portions, Radix Rhodiolae 7 weight portions, Fructus Hippophae 15 weight portions, Herba Micromeriae Biflorae 15 weight portions, Bulbus Lilii 21 weight portions, Radix Ophiopogonis 15 weight portion, Oxyria sinensis Hemsl. 15 weight portions, Rhizoma alpiniae pumilae 15 weight portions, volume stem knotweed 21 weight portions, Radix Oryzae Glutinosae 15 weight portions, Folium Fumicis Dentati 15 weight portions and Herba Hemisteptae Lyratae 19 weight portions.

Its preparation method comprises the following steps:

Second step, in the mixed powder that the first step obtains, add the ethanol that the determining alcohol with respect to 4 times of the quality of described mixed powder is 90%, stirring and dissolving obtains alcoholic solution, by alcoholic solution under the condition of 8 ℃ standing 30 hours, adopt percolation with the speed of 1ml per minute percolation slowly, collect percolate, concentrate and be dried, and at this, put into super micron mill and pulverize 50 minutes, obtain the mixed powder of the micron particles of 0.1～10 μ m volume average particle size and the nano-scale particle composition that particle diameter is less than 0.1 μ m volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,

The 3rd step, gets the mixed powder 15g that second step obtains, and adds propylene glycol 40g, adds 200ml water for injection, stirs it is dissolved, and further injects water to 1000ml, then adds 1g needle-use activated carbon, fully stirs 40 minutes; Decarbonization filtering; With 0.23 μ m filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.

Embodiment 3 liniments

The embodiment of the present invention provides a kind of pharmaceutical composition that is used for the treatment of caused by hepatic stagnation qi stagnation hypogalactia in puerperal, the parts by weight of its each raw medicinal material are: Pericarpium Citri Reticulatae Viride 10-20 weight portion, Semen Litchi 10-20 weight portion, Rhizoma Cyperi 15-25 weight portion, Fructus Citri Sarcodactylis 10-20 weight portion, Fructus Citri 10-20 weight portion, Flos Rosae Rugosae 10-20 weight portion, FLOS MUME 10-20 weight portion, Semen Aesculi 15-25 weight portion, Herba Aristolochiae 10-20 weight portion, Rhizoma Corydalis Decumbentis 10-15 weight portion, Herba Leonuri 15-25 weight portion, Herba Lycopi 15-25 weight portion, Caulis Spatholobi 10-20 weight portion, Semen Vaccariae 5-15 weight portion, Rhizoma et radix valerianae 10-20 weight portion, Cortex Albiziae 10-20 weight portion, Radix Codonopsis 10-20 weight portion, Radix Astragali 15-25 weight portion, Rhizoma Dioscoreae 15-25 weight portion, Radix Rhodiolae 5-10 weight portion, Fructus Hippophae 10-20 weight portion, Herba Micromeriae Biflorae 10-20 weight portion, Bulbus Lilii 15-25 weight portion, Radix Ophiopogonis 10-20 weight portion and Oxyria sinensis Hemsl. 10-20 weight portion.

Its preparation method comprises the following steps:

Step 2: can not drop into multi-function extractor by the coarse powder of 100 mesh sieves and extract twice, and add for the first time 9 times of water gagings of weight portion and decoct 2 hours, and add for the second time 7 times of water gagings of weight portion and decoct 2 hours, and merge twice decocting liquid, and filter to get filtrate; The heating of gained filtrate is concentrated into pasty state, puts into after 80 ℃ of oven dry of baking oven, room temperature is cooling, grinds to form fine powder b;

Toxicity test

1, animal is selected 40 of clean level kunming mices, male and female half and half, body weight 18～22 g; Laboratory observation 1 week, fasting 4 h before each administration, can't help water.To clean above level kunming mice laboratory observation 1 week, the clean level kunming mice of clinical observation result health will be divided into two groups, 20 every group (male and female half and half) at random.Wherein one group is set as experimental group, and another group is set as matched group.Mouse tail vein injection, experimental group, with successive administration in maximum (former) concentration of the injection of the embodiment of the present invention 2 and maximum volume 24 h 3 times, is given 0.6 ml/20 g(Mouse Weight) medicine, matched group is to the injection normal saline of same volume.Before administration, weigh the weight of animals and observe feed intake and drinking-water situation; After administration, weigh the weight of animals, feed intake and undue toxicity symptom at same time every day, Continuous Observation 14 d.By the observation of 14 d, do not have undue toxicity to react appearance, do not occur yet animal dead phenomenon, body weight change does not have notable difference (P > 0.05), illustrates that this injection does not have a significant effect to experiment mice body weight.

2, application NIH mice is 40, SPF level, and male and female half and half, body weight 18～22g, carries out acute toxicity test.Mice is divided into two groups at random, and 20 every group, matched group and administration group, test front fasting 12 hours; Tablet dissolved prepared by embodiments of the invention 1 is in water, (concentration is 6.58g crude drug/ml, maximum concentration) gavage, gavage volume is that 5ml/kg(is that single-dose dosage is 32.9 crude drugs/kg), matched group gives equivalent normal saline, administration in a day 2 times, delivery time 6 hours, after administration, Continuous Observation is 14 days, and record mice toxic reaction and death toll.Experimental result shows: with matched group comparison, after administration, mice has no notable difference, experiment Continuous Observation 14 days, and mice overall health of patients, diet, drinking-water, body weight gain are all normal.Mice oral administration gavage tablet LD50>32.9 of the present invention crude drug/kg, every day, maximum dosage-feeding was 65.8 crude drugs/kg/ day.Chinese medicine clinical application amount of the present invention is 4.4g crude drug/day/people, becomes body weight for humans in 60KG, and average dosage is 0.073g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight take 20g) oral administration gavage Chinese medicine of the present invention is quantity 901 times.Therefore tablet acute toxicity of the present invention is low, clinical drug safety.

3, by the embodiment of the present invention 1 containing tablet to mice by 7.81,18.34 and 12 weeks (1.0ml/100g body weight of 40.11g crude drug/kg continuous use, every day 2 times) and drug withdrawal after 4 weeks, result shows: Chinese medicine preparation of the present invention all has no significant effect indexs such as the hair of mice, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat, internal organs naked eyes do not find that difference changes and histological examination result shows, medication 12 weeks and drug withdrawal are after 4 weeks, and Organs of Mice is all without obviously changing.Illustrate that toxicity is little after Chinese medicine preparation of the present invention is to mice long-term prescription, after drug withdrawal, also there is no difference reaction, application safety.

4, SD rat is 20, male and female half and half, body weight 90g～180g, percutaneous of liniment that the embodiment of the present invention 3 is obtained is smeared 5000mg/kg body weight dosage, observe 15 days, do not find obvious poisoning symptom, nothing death, animal gross anatomy no abnormality seen, judges that these product are to the nontoxic level in the true border of rat acute percutaneous toxicity.

5, get 18 of healthy albino guinea-pigs, body weight 250-300g, male and female dual-purpose, rejects both sides dorsal body setae before test, and every side 3 * 3cm, is divided into test group, blank group (substrate) and positive controls at random.Positive controls DNFB, sensitization 1% concentration, excites and uses 0.1% concentration.The liniment 0.1g that gets the embodiment of the present invention 3 is applied to unhairing district, back, the next day 1 time, totally 3 times.In last, contact latter 14 days, at back the same area, smear this product 0.1g, after 6h, remove after medicine and at once observe, and in 24,48,72h observes and has or not anaphylaxis.Blank group is used same method to excite with positive controls and is contacted and observe.Result of the test: localized erythema and slight edema appear in positive controls animal skin after 1 hour in sensitization, within 24 hours, symptoms of allergic increases the weight of, and there is scleroma to form, sensitization rate is 100%, all there is not any symptoms of allergic in test group and blank treated animal skin, sensitization rate is 0%.

Clinical trial

Case selection: fetch and come from the puerpera of the court obstetrics 150 example caused by hepatic stagnation qi stagnation hypogalactia patients in puerperal, age 29-41 year, cesarean 86 examples, spontaneous labor 64 examples, 3 days puerperal-1 month milk very less or completely without, have following symptom in various degree: milk is dense thick, or agalactia, the hard pain of mammary swelling, depressed emotion, breast side of body feeling of distension and oppression, inappetence, or slight fever, body of the tongue is normal, yellow and thin fur, stringy and thready pulse or stringy and rapid pulse.150 routine patients are divided into three groups at random, every group of 50 examples.

Therapeutic Method:

Embodiment group 1: take the tablet of the embodiment of the present invention 1, every day twice, each three, take continuously 3-7 days;

Embodiment group 2: use the injection of the embodiment of the present invention 2, once a day, each 50mg/kg, is no more than 4g every day, uses continuously 3-7;

Matched group: take Os Sus domestica Fructus Lycopersici esculenti medicated porridge, every day twice, use continuously 3-7 days.

Criterion of therapeutical effect: recovery from illness: galactopoiesis is normal, normally suckling; Effective: galactopoiesis increases, or galactopoiesis is normal, but amount is few, feeds not; Invalid: galactopoiesis is without change; Wherein, effective percentage is that recovery from illness number and significant figure sum account for total percentage ratio.

Therapeutic outcome:

Referring to table 1 and table 2, as can be seen from Table 1, adopt medicine composite for curing caused by hepatic stagnation qi stagnation in puerperal hypogalactia of the present invention, with respect to traditional Dietotherapy method, in curative effect, there is significant improvement; As can be seen from Table 2, adopt medicine composite for curing caused by hepatic stagnation qi stagnation in puerperal hypogalactia of the present invention, with respect to traditional Dietotherapy method, treating significantly shortening on the course for the treatment of.

Each experimental group of table 1 is treated respectively Clinical efficacy comparison example after 3-7 days

Group	Number of cases	Cure	Effectively	Invalid	Effective percentage
						Embodiment group 1	50	27	20	3	94%
Embodiment group 2	50	29	19	2	96%
						Matched group	50	17	19	14	72%

Each experimental group of table 2 is treated respectively rear healing in 3-7 days and efficiently individual quantity and time comparative example (%)

Group	Number of cases	1-3 days	3-5 days	6-7 days
					Embodiment group 1	47	4（8.5%）	25（53.2%）	18（38.3%）
Embodiment group 2	48	6（12.5%）	26（54.2%）	16（33.3%）
					Matched group	36	2（5.6%）	9（25.0%）	25（69.4%）

Known according to the clinical statistics in above table, that pharmaceutical composition provided by the invention has is rapid-action, effective percentage is high, determined curative effect, safe, the advantage that has no side effect.

Model case 1: grandson, 27 years old, spontaneous labor, body constitution is relatively become thin, 3 days puerperal agalactia, the hard pain of mammary swelling, depressed emotion, breast side of body feeling of distension and oppression, inappetence, yellow and thin fur, stringy and thready pulse.Through inquiry household, grandson's goodwill as between spouses discord, antenatal quarrel.Disease belongs to caused by hepatic stagnation qi stagnation hypogalactia in puerperal.Use the injection of the embodiment of the present invention 2 to treat and be used in conjunction with the liniment of the embodiment of the present invention 3, injection once a day, each 50mg/kg, be no more than 4g every day, every day smeared breast three times by liniment, use continuously 2 days effective afterwards, continual cure 2 days, recovery from illness, follows up a case by regular visits to and does not recur half a year.

Model case 2: Liu, 34 years old, cesarean, breast is few, because worrying that hypogalactia affects child and grows, with anxiety.The hard pain of mammary swelling, depressed emotion, breast side of body feeling of distension and oppression, slight fever, body of the tongue is normal, yellow and thin fur, wiry and frequent pulse.Disease belongs to caused by hepatic stagnation qi stagnation hypogalactia in puerperal.Use the tablet of the embodiment of the present invention 1 to treat, every day twice, each three, take continuously 4 days effectively, continue to take recovery from illness in 2 days, galactopoiesis is normal, and normally suckling, follows up a case by regular visits to and does not recur half a year.

The foregoing is only preferred embodiment of the present invention, in order to limit the present invention, within the spirit and principles in the present invention not all, any modification of doing, be equal to replacement, improvement etc., within all should being included in protection scope of the present invention.

Claims

1. the pharmaceutical composition that is used for the treatment of caused by hepatic stagnation qi stagnation hypogalactia in puerperal, it is characterized in that, described pharmaceutical composition comprises following raw medicinal material: Pericarpium Citri Reticulatae Viride, Semen Litchi, Rhizoma Cyperi, Fructus Citri Sarcodactylis, Fructus Citri, Flos Rosae Rugosae, FLOS MUME, Semen Aesculi, Herba Aristolochiae, Rhizoma Corydalis Decumbentis, Herba Leonuri, Herba Lycopi, Caulis Spatholobi, Semen Vaccariae, Rhizoma et radix valerianae, Cortex Albiziae, Radix Codonopsis, the Radix Astragali, Rhizoma Dioscoreae, Radix Rhodiolae, Fructus Hippophae, Herba Micromeriae Biflorae, Bulbus Lilii, Radix Ophiopogonis and Oxyria sinensis Hemsl..

2. the pharmaceutical composition that is used for the treatment of caused by hepatic stagnation qi stagnation hypogalactia in puerperal according to claim 1, it is characterized in that, in described pharmaceutical composition, the parts by weight of each raw medicinal material are: Pericarpium Citri Reticulatae Viride 10-20 weight portion, Semen Litchi 10-20 weight portion, Rhizoma Cyperi 15-25 weight portion, Fructus Citri Sarcodactylis 10-20 weight portion, Fructus Citri 10-20 weight portion, Flos Rosae Rugosae 10-20 weight portion, FLOS MUME 10-20 weight portion, Semen Aesculi 15-25 weight portion, Herba Aristolochiae 10-20 weight portion, Rhizoma Corydalis Decumbentis 10-15 weight portion, Herba Leonuri 15-25 weight portion, Herba Lycopi 15-25 weight portion, Caulis Spatholobi 10-20 weight portion, Semen Vaccariae 5-15 weight portion, Rhizoma et radix valerianae 10-20 weight portion, Cortex Albiziae 10-20 weight portion, Radix Codonopsis 10-20 weight portion, Radix Astragali 15-25 weight portion, Rhizoma Dioscoreae 15-25 weight portion, Radix Rhodiolae 5-10 weight portion, Fructus Hippophae 10-20 weight portion, Herba Micromeriae Biflorae 10-20 weight portion, Bulbus Lilii 15-25 weight portion, Radix Ophiopogonis 10-20 weight portion and Oxyria sinensis Hemsl. 10-20 weight portion.

3. the pharmaceutical composition that is used for the treatment of caused by hepatic stagnation qi stagnation hypogalactia in puerperal according to claim 1 and 2, it is characterized in that, in described pharmaceutical composition, the parts by weight of each raw medicinal material are: Pericarpium Citri Reticulatae Viride 15 weight portions, Semen Litchi 16 weight portions, Rhizoma Cyperi 21 weight portions, Fructus Citri Sarcodactylis 15 weight portions, Fructus Citri 15 weight portions, Flos Rosae Rugosae 15 weight portions, FLOS MUME 13 weight portions, Semen Aesculi 17 weight portions, Herba Aristolochiae 14 weight portions, Rhizoma Corydalis Decumbentis 12 weight portions, Herba Leonuri 20 weight portions, Herba Lycopi's 19 weight portions, Caulis Spatholobi 15 weight portions, Semen Vaccariae 8 weight portions, Rhizoma et radix valerianae 15 weight portions, Cortex Albiziae 12 weight portions, Radix Codonopsis 16 weight portions, the Radix Astragali 20 weight portions, Rhizoma Dioscoreae 20 weight portions, Radix Rhodiolae 7 weight portions, Fructus Hippophae 15 weight portions, Herba Micromeriae Biflorae 15 weight portions, Bulbus Lilii 21 weight portions, Radix Ophiopogonis 15 weight portion and Oxyria sinensis Hemsl. 15 weight portions.

4. according to the pharmaceutical composition that is used for the treatment of caused by hepatic stagnation qi stagnation hypogalactia in puerperal described in claim 1-3 any one, it is characterized in that, described pharmaceutical composition also comprises: Rhizoma alpiniae pumilae, volume stem knotweed, Radix Oryzae Glutinosae, Folium Fumicis Dentati and Herba Hemisteptae Lyratae.

5. according to the pharmaceutical composition that is used for the treatment of caused by hepatic stagnation qi stagnation hypogalactia in puerperal described in claim 1-4 any one, it is characterized in that, in described pharmaceutical composition, the parts by weight of each raw medicinal material are: Pericarpium Citri Reticulatae Viride 10-20 weight portion, Semen Litchi 10-20 weight portion, Rhizoma Cyperi 15-25 weight portion, Fructus Citri Sarcodactylis 10-20 weight portion, Fructus Citri 10-20 weight portion, Flos Rosae Rugosae 10-20 weight portion, FLOS MUME 10-20 weight portion, Semen Aesculi 15-25 weight portion, Herba Aristolochiae 10-20 weight portion, Rhizoma Corydalis Decumbentis 10-15 weight portion, Herba Leonuri 15-25 weight portion, Herba Lycopi 15-25 weight portion, Caulis Spatholobi 10-20 weight portion, Semen Vaccariae 5-15 weight portion, Rhizoma et radix valerianae 10-20 weight portion, Cortex Albiziae 10-20 weight portion, Radix Codonopsis 10-20 weight portion, Radix Astragali 15-25 weight portion, Rhizoma Dioscoreae 15-25 weight portion, Radix Rhodiolae 5-10 weight portion, Fructus Hippophae 10-20 weight portion, Herba Micromeriae Biflorae 10-20 weight portion, Bulbus Lilii 15-25 weight portion, Radix Ophiopogonis 10-20 weight portion, Oxyria sinensis Hemsl. 10-20 weight portion, Rhizoma alpiniae pumilae 10-20 weight portion, volume stem knotweed 15-25 weight portion, Radix Oryzae Glutinosae 10-20 weight portion, Folium Fumicis Dentati 10-20 weight portion and Herba Hemisteptae Lyratae 15-25 weight portion.

6. according to the pharmaceutical composition that is used for the treatment of caused by hepatic stagnation qi stagnation hypogalactia in puerperal described in claim 1-5 any one, it is characterized in that, in described pharmaceutical composition, the parts by weight of each raw medicinal material are: Pericarpium Citri Reticulatae Viride 15 weight portions, Semen Litchi 16 weight portions, Rhizoma Cyperi 21 weight portions, Fructus Citri Sarcodactylis 15 weight portions, Fructus Citri 15 weight portions, Flos Rosae Rugosae 15 weight portions, FLOS MUME 13 weight portions, Semen Aesculi 17 weight portions, Herba Aristolochiae 14 weight portions, Rhizoma Corydalis Decumbentis 12 weight portions, Herba Leonuri 20 weight portions, Herba Lycopi's 19 weight portions, Caulis Spatholobi 15 weight portions, Semen Vaccariae 8 weight portions, Rhizoma et radix valerianae 15 weight portions, Cortex Albiziae 12 weight portions, Radix Codonopsis 16 weight portions, the Radix Astragali 20 weight portions, Rhizoma Dioscoreae 20 weight portions, Radix Rhodiolae 7 weight portions, Fructus Hippophae 15 weight portions, Herba Micromeriae Biflorae 15 weight portions, Bulbus Lilii 21 weight portions, Radix Ophiopogonis 15 weight portion, Oxyria sinensis Hemsl. 15 weight portions, Rhizoma alpiniae pumilae 15 weight portions, volume stem knotweed 21 weight portions, Radix Oryzae Glutinosae 15 weight portions, Folium Fumicis Dentati 15 weight portions and Herba Hemisteptae Lyratae 19 weight portions.

7. according to the preparation method of the pharmaceutical composition that is used for the treatment of caused by hepatic stagnation qi stagnation hypogalactia in puerperal described in claim 1-6 any one, it is characterized in that, the dosage form of described pharmaceutical composition is tablet, and described preparation method comprises the following steps:

8. according to the preparation method of pharmaceutical composition for caused by hepatic stagnation qi stagnation hypogalactia in puerperal described in claim 1-6 any one, it is characterized in that, the dosage form of described pharmaceutical composition is injection, and described preparation method comprises the following steps:

9. according to the preparation method of pharmaceutical composition for caused by hepatic stagnation qi stagnation hypogalactia in puerperal described in claim 1-6 any one, it is characterized in that, the dosage form of described pharmaceutical composition is liniment, and described preparation method comprises the following steps: