CN105079451A - Blood-glucose-reducing blueberry tea and preparation method thereof - Google Patents

Blood-glucose-reducing blueberry tea and preparation method thereof Download PDF

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CN105079451A
CN105079451A CN201510500338.8A CN201510500338A CN105079451A CN 105079451 A CN105079451 A CN 105079451A CN 201510500338 A CN201510500338 A CN 201510500338A CN 105079451 A CN105079451 A CN 105079451A
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weight portion
radix
blue berry
herba
blood
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CN105079451B (en
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秦赤
杨春香
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Shanghai Shanqiu Liankang Health Management Co., Ltd
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Anhui Jinshuiyuan Ecological Agriculture Co Ltd
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Abstract

The invention provides blood-glucose-reducing blueberry tea. The blood-glucose-reducing blueberry tea comprises blueberries, blueberry leaves, Chinese wolfberry fruit, kudzuvine roots, manyprickle acanthopanax roots, mistletoe, nutmeg, cortex phellodendri, liriope spicata, polygonatum kingianum, aralia yunnanensis Franch., buckwheat, fragrant sarcococca herb, schisandra propinqua (Wall.) Baill., radix hedysari, semen euryales, bunge corydalis herb, herba gerberae piloselloidis and notopterygium roots. The blood-glucose-reducing blueberry tea has the advantages that by making full use of the advantages of the blueberries and the traditional Chinese medicines on diabetes treatment, the blood-glucose-reducing blueberry tea which is made into a blood-glucose-reducing herbal tea drink can keep specific treatment effect of a traditional Chinese medicine compound prescription, overcome drawbacks of other dosage forms, give full play to nutrition and health care effects of the blueberries and enable adults and children to accept with pleasure, thereby being quite suitable for long-term oral administration.

Description

A kind of blue berry blood-sugar reducing tea and preparation method thereof
Technical field
The present invention relates to health promoting product technical field, particularly relate to a kind of blue berry blood-sugar reducing tea and preparation method thereof.
Background technology
Blue berry, is commonly referred to Fructus vaccini vitis-idaeae, is one of current the most ancient fruit in the world, it is estimated general 13, just has its figure on earth before 000 year.Its nutritive value, far above other fruit, can be rated as " king of world's berry ", is world development fruit variety the most rapidly in recent years, fashionable America and Europe.Blue berry is the fruit that in fruit and vegerable, anthocyanidin content is the highest, anthocyanidin mainly contain anti-visual deterioration, blood pressure lowering, slow down aging, anticancer, improve the effect such as memory, angiocardiopathy preventing and blood fat reducing.
Blue berry has very high nutritive value and health care, is classified as one of large health food of the mankind five by international food and agricultural organization.As a kind of epoch fruit of health, the development of blue berry and being worth just constantly is taken seriously, and along with the development of science and the continuous innovation of technology, the purposes of blue berry and effect will constantly be developed as the health of the mankind adds a blue elegance.
Diabetes are one of three large killers of harm humans health, and be only second to cancer and cardiovascular and cerebrovascular disease, its sickness rate has the trend risen year by year in recent years.Report, Chinese metropolitan onset diabetes rate (such as Shanghai 10%) has exceeded U.S.'s (6.3%).Following 20 years, diabetes mellitus in China will be rapidly to cities and towns and spread, and the most vast rural area of Zhongdao is spread on a large scale.If do not prevented, within 2025, whole diabetes mellitus in China sickness rate may up to 20%, and diabetes total population may be increased to 300,000,000.
Containing 0.41g/100g pectin in Blueberry, pectin belongs to water soluble dietary fiber, regulate post-prandial glycemia, promote intestinal beneficial bacterium propagation, chyle fat, cholesterol and heavy metal is not digested, effectively the various modern " ciril disease " such as prevention and adjuvant therapy of heart cerebrovascular diseases, diabetes, cancer, constipation, Overweight and obesity in purged body.
Doctor trained in Western medicine hypoglycemic drug diabetes curative effect affirmative, but life-time service needs dosage gradually, mostly has untoward reaction in various degree, and effectively can not control complication.
TCM treatment of diabetes has the history of several thousand, and first "Nei Jing" records name of disease of quenching one's thirst, and thinks that the five internal organs weakness, surfeit delicious food, disorder of emotion cause the reason of quenching one's thirst.Interior-heat is its main pathogenesis." Medical Treasures of the Golden Chamber " vertical special section of quenching one's thirst, and the earliest treatment side's medicine is proposed.Later many doctors have all done the clinical characters of quenching one's thirst, complication and clinical classification and have comparatively developed, and treat, still have certain guidance meaning to the clinical syndrome differentiation of today., lessly there is toxicity in Chinese medicine action temperature and lasting, Chinese herb decoction flexibly, giving treatment in accordance with the patient’s individuality, integrally-regulated, the health of two-ways regulation patient; Mutiple Targets, multipath, multilevel effect, have the irreplaceable advantage of doctor trained in Western medicine for improving index of correlation (blood fat, blood viscosity, microcirculation, antioxidation etc.).
In many Therapeutic Method of the traditional Chinese medical science, Chinese medicine medicated tea is a kind of well Therapeutic Method.Chinese medicine medicated tea, also known as medicinal tea, is furnished with by Chinese herbal medicine (single or compound recipe) preparation that Folium Camelliae sinensis or the medicine of not being furnished with Folium Camelliae sinensis process from strand.Taking when applying boiling water soak extracting juice clothes or add decocting juice clothes more, the effect of disease therapy or health care can be played with epoch tea-drinking.Agent treatment traditional for Chinese medicine is reformed into and brews dietetic therapy, can reach not only convenient but also the object of drug effect can be ensured.
The applicant of the application uses theory of Chinese medical science determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, make full use of blue berry and the advantage of Chinese medicine in treatment diabetes, make antidiabetic drug tea beverage, both the peculiar curative effect of Chinese medicine compound had been remained, overcome the drawback of other dosage form, given full play to again the nutritional health function of blue berry, adult child all takes like a shot, and is very suitable for Long-term Oral.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of blue berry blood-sugar reducing tea, make full use of blue berry and the advantage of Chinese medicine in treatment diabetes, make antidiabetic drug tea beverage, both the peculiar curative effect of Chinese medicine compound had been remained, overcome the drawback of other dosage form, given full play to again the nutritional health function of blue berry, adult child all takes like a shot, and is very suitable for Long-term Oral.
For solving the problems of the technologies described above, the invention provides a kind of blue berry blood-sugar reducing tea, its raw material comprises blue berry, Blue berry leaf, Fructus Lycii, Radix Puerariae, Radix Et Caulis Acanthopanacis Senticosi, Herba Visci, Semen Myristicae, Cortex Phellodendri, Radix Liriopes, Rhizoma Polygonati, careless Radix Angelicae Pubescentis, Semen Fagopyri Esculenti, Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae), Herba Schisandrae intermediae, Radix Hedysari, Semen Euryales, Herba Corydalis Bungeanae, Herba Gerberae Piloselloidis and Rhizoma Et Radix Notopterygii.
Wherein, in described blue berry blood-sugar reducing tea, the weight portion of each raw material is respectively blue berry 50 weight portion ~ 60 weight portion, Blue berry leaf 35 weight portion ~ 45 weight portion, Fructus Lycii 10 weight portion ~ 20 weight portion, Radix Puerariae 5 weight portion ~ 15 weight portion, Radix Et Caulis Acanthopanacis Senticosi 10 weight portion ~ 20 weight portion, Herba Visci 5 weight portion ~ 15 weight portion, Semen Myristicae 10 weight portion ~ 20 weight portion, Cortex Phellodendri 5 weight portion ~ 15 weight portion, Radix Liriopes 10 weight portion ~ 20 weight portion, Rhizoma Polygonati 5 weight portion ~ 15 weight portion, grass Radix Angelicae Pubescentis 5 weight portion ~ 15 weight portion, Semen Fagopyri Esculenti 10 weight portion ~ 20 weight portion, Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae) 5 weight portion ~ 15 weight portion, Herba Schisandrae intermediae 5 weight portion ~ 15 weight portion, Radix Hedysari 10 weight portion ~ 20 weight portion, Semen Euryales 5 weight portion ~ 15 weight portion, Herba Corydalis Bungeanae 10 weight portion ~ 20 weight portion, Herba Gerberae Piloselloidis 5 weight portion ~ 15 weight portion and Rhizoma Et Radix Notopterygii 10 weight portion ~ 20 weight portion.
Wherein, in described blue berry blood-sugar reducing tea, the weight portion of each raw material is respectively blue berry 53 weight portion ~ 57 weight portion, Blue berry leaf 38 weight portion ~ 42 weight portion, Fructus Lycii 13 weight portion ~ 17 weight portion, Radix Puerariae 8 weight portion ~ 12 weight portion, Radix Et Caulis Acanthopanacis Senticosi 13 weight portion ~ 17 weight portion, Herba Visci 8 weight portion ~ 12 weight portion, Semen Myristicae 13 weight portion ~ 17 weight portion, Cortex Phellodendri 8 weight portion ~ 12 weight portion, Radix Liriopes 13 weight portion ~ 17 weight portion, Rhizoma Polygonati 8 weight portion ~ 12 weight portion, grass Radix Angelicae Pubescentis 8 weight portion ~ 12 weight portion, Semen Fagopyri Esculenti 13 weight portion ~ 17 weight portion, Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae) 8 weight portion ~ 12 weight portion, Herba Schisandrae intermediae 8 weight portion ~ 12 weight portion, Radix Hedysari 13 weight portion ~ 17 weight portion, Semen Euryales 8 weight portion ~ 12 weight portion, Herba Corydalis Bungeanae 13 weight portion ~ 17 weight portion, Herba Gerberae Piloselloidis 8 weight portion ~ 12 weight portion and Rhizoma Et Radix Notopterygii 13 weight portion ~ 17 weight portion.
Wherein, in described blue berry blood-sugar reducing tea, the weight portion of each raw material is respectively blue berry 55 weight portion, Blue berry leaf 40 weight portion, Fructus Lycii 15 weight portion, Radix Puerariae 10 weight portion, Radix Et Caulis Acanthopanacis Senticosi 15 weight portion, Herba Visci 10 weight portion, Semen Myristicae 15 weight portion, Cortex Phellodendri 10 weight portion, Radix Liriopes 15 weight portion, Rhizoma Polygonati 10 weight portion, careless Radix Angelicae Pubescentis 10 weight portion, Semen Fagopyri Esculenti 15 weight portion, Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae) 10 weight portion, Herba Schisandrae intermediae 10 weight portion, Radix Hedysari 15 weight portion, Semen Euryales 10 weight portion, Herba Corydalis Bungeanae 15 weight portion, Herba Gerberae Piloselloidis 10 weight portion and Rhizoma Et Radix Notopterygii 15 weight portion.
Present invention also offers the preparation method of above-mentioned blue berry blood-sugar reducing tea, it comprises:
The first step, the process of Blue berry leaf, the choosing of leaf is plucked after fruit harvest, and the leaf on the branch of predetermined beta pruning is plucked, and to carry out before blade reddens, clean after harvesting, then carry out the natural drying of 15 ~ 20h, dried blade is loaded cloth bag, 15min is rubbed with hand rubbing, then be placed in drying baker at 100 DEG C of temperature, dry 1h, is ground into powder subsequently;
Second step, the process of blue berry, after the fruit that granule is little, colour-difference can not be gone on the market is picked out, foreign material, cleaning, the drenches such as removing branch and leaf are done, are loaded refrigerator-freezer pre-freeze, pre-freezing temperature is-30 DEG C, drying, is chilled to-35 DEG C in advance by cold-trap, opens dry door, load the blue berry of deep colling, shut door, start vacuum pump set and find time, when vacuum reaches 60Pa, start heating, need in heating process to ensure stable working vacuum degree, and ensure that article maximum temperature is no more than 50 DEG C, average dehydration reaches 82.6%;
3rd step, prepares the effective extract component powder of Chinese herbal medicine;
4th step, by the Blue berry leaf powder that the first step obtains, the blue berry that second step obtains and the effective extract component powder of Chinese herbal medicine that the 3rd step obtains mix, and ultraviolet-sterilization is sterilized, and with Folium Camelliae sinensis bag splendid attire, obtain blue berry blood-sugar reducing tea.
Wherein, described 3rd step is specially further and each crude drug is ground into powder respectively according to above-mentioned weight portion, mixing, obtain mixed-powder, add with the water of mixed-powder total weight 3 ~ 8 times amount, decoct 2 hours, filter, add with the water of mixed-powder total weight 3 ~ 8 times amount in medicinal residues, decoct 2 hours, filter, merging filtrate, concentrated except anhydrating, be dried to powder.
Beneficial effect of the present invention:
The invention provides a kind of blue berry blood-sugar reducing tea, it makes full use of blue berry and the advantage of Chinese medicine in treatment diabetes, make antidiabetic drug tea beverage, both the peculiar curative effect of Chinese medicine compound had been remained, overcome the drawback of other dosage form, given full play to again the nutritional health function of blue berry, adult child all takes like a shot, and is very suitable for Long-term Oral.
Detailed description of the invention
The invention provides a kind of blue berry blood-sugar reducing tea, its raw material comprises blue berry, Blue berry leaf, Fructus Lycii, Radix Puerariae, Radix Et Caulis Acanthopanacis Senticosi, Herba Visci, Semen Myristicae, Cortex Phellodendri, Radix Liriopes, Rhizoma Polygonati, careless Radix Angelicae Pubescentis, Semen Fagopyri Esculenti, Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae), Herba Schisandrae intermediae, Radix Hedysari, Semen Euryales, Herba Corydalis Bungeanae, Herba Gerberae Piloselloidis and Rhizoma Et Radix Notopterygii.
Further preferably, described blue berry blood-sugar reducing tea is only prepared from by above-mentioned raw materials.
Each crude drug pharmacology is as follows:
Blue berry: also known as Pericarpium Citri tangerinae, blue berry.Belong to the perennial fallen leaves of Ericaceae Vaccinium or evergreen shrubs, mainly contain short clump, Gao Cong, lagophthalmos and half high clump four major types.Fruit is oblate, is navy blue after ripe.Blueberry contains abundant anthocyanin, in addition also containing mineral such as carbohydrate, organic acid, cellulose, Vc, flavone, potassium, calcium, phosphorus.Blue berry is rich in anthocyanin, low sugar, low fat, oxidation resistance is strong, containing 0.41g/100g pectin in Blueberry, pectin belongs to water soluble dietary fiber, regulate post-prandial glycemia, promote intestinal beneficial bacterium propagation, in purged body, do not digest chyle fat, cholesterol and heavy metal, effectively the various modern " ciril disease " such as prevention and adjuvant therapy of heart cerebrovascular diseases, diabetes, cancer, constipation, Overweight and obesity.
Fructus Lycii: latin name lyciifructus, sweet in the mouth, property are flat, enter liver, kidney channel, have liver and kidney tonifying, nourish blood enrich blood, the effect of replenishing vital essence to improve eyesight, nourishing the lung to arrest cough, be mainly used in Liver and kidney two void, the soreness of the waist and knees of asthenia of essence and blood, dizziness and tinnitus, seminal emission tinnitus, unconsciously sweat and tire; The sexual impotence of insufficiency of kidney-YANG, sterile; The cards such as the dim-sighted and deficiency of YIN chronic cough of the eyes of deficiency of YIN-essence, deficiency of liver-blood, Fructus Lycii can promote liver cell regeneration, the effect of enhancing non-specific immunity function.
Radix Puerariae: latin name puerariaeLobataeRadix,sweet in the mouth, pungent, cool in nature, enter spleen, stomach warp, have inspiration gastric qi, clearing away heat and promoting production of body fluid, expelling pathogenic factors from muscles is delivered, and raw sun, oozes the effect of rash, be mainly used in fever caused by exogenous pathogens, headache, stiff nape and back, and calentura is thirsty, quenches one's thirst; Diarrhea due to hypofunction of the spleen, the cards such as clear YANG failing to ascend.
Radix Et Caulis Acanthopanacis Senticosi: be the root of studies on plants of Acanthopanax Miq. in Araliaceae Radix Et Caulis Acanthopanacis Senticosi, rhizome or stem and leaf, latin name acanthopanacisSenticosiRadixetRhizomaseuCaulis, acrid in the mouth, hardship, micro-sweet, warm in nature, enter spleen, kidney, heart channel, there is replenishing QI to invigorate the spleen, tonifying the kidney for tranquilization, effect of expelling wind and removing dampness, soft for anemofrigid-damp arthralgia, lumbocrural pain, muscles and bones flaccidity, be slow in action, the card such as body weakness with emaciation is weak, traumatic injury, fracture, edema, beriberi, uncontrolled urination are itched.
Herba Visci: bitter in the mouth, sweet, property is put down, and enters liver, kidney channel, has invigorating the liver and kidney, bone and muscle strengthening, wind-damp dispelling, antiabortive effect, for the soreness of waist and knee joint caused by deficiency of the liver and kindey, muscles and bones flaccidity is soft, the foot and knee being feeble, rheumatic arthralgia, articular instability, the cards such as the frequent fetal movement that asthenia of renal qi causes.
Semen Myristicae: latin name myristicaesemen, acrid in the mouth, bitter, warm in nature, return spleen, stomach, large intestine channel, have warming middle-JIAO astringing intestine to stop diarrhea, effect of promote qi circulation digestion promoting, for diarrhea of deficiency type; Cold-dysentery; Abdominal distention; Lack of appetite is vomitted; Dyspepsia such as not to disappear at the card.
Cortex Phellodendri: bitter in the mouth, cold in nature, return kidney, bladder, large intestine channel, have heat clearing and damp drying, eliminating fire and detoxication, except effect of hectic fever due to YIN-deficiency clearind deficient heat, for damp-heat dysentery, jaundice, leukorrhagia, pyretic stranguria, beriberi, flaccidity is warded off, hectic fever due to YIN-deficiency consumptive fever, night sweat, seminal emission, sore swollen toxin, the cards such as eczema pruritus.
Radix Liriopes: latin name liriopesradix, sweet in the mouth, micro-hardship, cold nature, GUIXIN, lung, stomach warp, have YIN nourishing and the production of body fluid promoting, effect that lung moistening clears away heart-fire, and for dryness of the lung dry cough, cough due to consumptive disease, Tianjin wound is thirsty, vexed insomnia, the cards such as dryness of the intestine constipation.
Rhizoma Polygonati: sweet in the mouth, property is put down, and returns lung, spleen, kidney channel, has nourishing kidney lung moistening, effect of invigorating the spleen and replenishing QI, cures mainly deficiency of YIN chronic cough, xeropulmonary cough, insufficiency of the spleen weak, and lack of appetite xerostomia, quenches one's thirst, deficiency of the kidney soreness of the waist and knees, impotence and seminal emission, tinnitus order is dark, early whitening of beard and hair, and body void is won thin, effect of wind favus disease.
Grass Radix Angelicae Pubescentis: be the root of Wu Jia Ke Cortex araliae chinensis platymiscium Yunnan Radix Ariliae, bitter in the mouth, pungent, slightly warm in nature, has dispersing wind-cold, invigorating spleen for diuresis, relaxing muscles and tendons and activating QI and blood in the collateral.Cure mainly anemofrigid cold, cough, edema due to deficiency of the spleen, infantile malnutrition, pain in chest and hypochondrium, treating swelling and pain by traumatic injury, rheumatalgia, lumbago, fracture, menoxenia, the cards such as traumatic hemorrhage.
Semen Fagopyri Esculenti: be the seed of buckwheat Plant Buckwheat, sweet in the mouth, micro-acid, cold in nature, return spleen, stomach, large intestine channel, there is spleen invigorating removing food stagnancy, the wide intestinal of the therapeutic method to keep the adverse QI flowing downwards, effect of removing toxic substances sore, cures mainly the intestines and stomach and stagnates, have loose bowels, dysentery, nebulousurine, leukorrhagia, spontaneous perspiration, night sweat, herpes, erysipelas, carbuncle on the back, the cards such as burn and scald.
Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae): be the root of Buxaceae Sarcococca plant open country fan flower, acrid in the mouth, hardship, property is put down, and has promoting flow of QI and blood, effect of wind-expelling pain-stopping, cures mainly the cards such as gastritis, stomachache, rheumatalgia.
Herba Schisandrae intermediae: be rattan and the root that Schisandraceae schisandra plant closes stamen Fructus Schisandrae Chinensis, bitter in the mouth, pungent, property is put down, and return Liver Channel, have heat-clearing and toxic substances removing, effect of promoting blood circulation and detumescence, cures mainly influenza, carbuncle sore tumefacting virus, venom, rheumatic numbness, traumatic injury, the cards such as menoxenia.
Radix Hedysari: latin name radixHedysari, sweet in the mouth, warm in nature, return lung, spleen channel, there is invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, effect of expelling pus and promoting granulation, cure mainly the deficiency of vital energy weak, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle difficulty is burst, blood deficiency and yellow complexion, interior-heat is quenched one's thirst, chronic nephritis proteinuria, the cards such as diabetes.
Semen Euryales: sweet in the mouth, puckery, property is put down.Return spleen, kidney channel.Have supplementing the kidney to control the nocturnal, spleen reinforcing antidiarrheal, the function of damp eliminating leukorrhagia stopping, cures mainly emission, diarrhea due to hypofunction of the spleen, and insufficiency of the spleen nebulousurine is with inferior card.
Herba Corydalis Bungeanae: latin name corydalisBungeanaeHerba, bitter in the mouth, cold in nature, GUIXIN, liver, large intestine channel, have effect of heat-clearing and toxic substances removing, mass dissipating and swelling eliminating, cures mainly epidemic disease flu, laryngopharynx swelling and pain, carbuncle carbuncle on the back, treats skin ulcer and the card such as to swell and ache.
Herba Gerberae Piloselloidis: bitter in the mouth, pungent, property is put down, and have lung qi dispersing cough-relieving, heat-clearing and toxic substances removing, dampness removing, effect of promoting flow of QI and blood, cures mainly the cough due to common cold, and asthma is had loose bowels, dysentery, edema, stranguria with turbid discharge, epigastric distending pain, treating swelling and pain by traumatic injury, the cards such as venom.
Rhizoma Et Radix Notopterygii: latin name notopterygiiRhizomaetRadix,acrid in the mouth, hardship, warm in nature, enter kidney, urinary bladder channel, have effect of the cold expelling that induces sweat, expelling wind and dampness, pain relieving, have the wet exterior syndrome of wind and cold folder, disease sees that fever with aversion to cold, headache are as wrapped up in, neck rigid back pain, the cards such as limbs are heavy, and joint is ached, anemofrigid-damp arthralgia.
Wherein, in described blue berry blood-sugar reducing tea, the weight portion of each raw material is respectively blue berry 50 weight portion ~ 60 weight portion, Blue berry leaf 35 weight portion ~ 45 weight portion, Fructus Lycii 10 weight portion ~ 20 weight portion, Radix Puerariae 5 weight portion ~ 15 weight portion, Radix Et Caulis Acanthopanacis Senticosi 10 weight portion ~ 20 weight portion, Herba Visci 5 weight portion ~ 15 weight portion, Semen Myristicae 10 weight portion ~ 20 weight portion, Cortex Phellodendri 5 weight portion ~ 15 weight portion, Radix Liriopes 10 weight portion ~ 20 weight portion, Rhizoma Polygonati 5 weight portion ~ 15 weight portion, grass Radix Angelicae Pubescentis 5 weight portion ~ 15 weight portion, Semen Fagopyri Esculenti 10 weight portion ~ 20 weight portion, Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae) 5 weight portion ~ 15 weight portion, Herba Schisandrae intermediae 5 weight portion ~ 15 weight portion, Radix Hedysari 10 weight portion ~ 20 weight portion, Semen Euryales 5 weight portion ~ 15 weight portion, Herba Corydalis Bungeanae 10 weight portion ~ 20 weight portion, Herba Gerberae Piloselloidis 5 weight portion ~ 15 weight portion and Rhizoma Et Radix Notopterygii 10 weight portion ~ 20 weight portion.
Wherein, in described blue berry blood-sugar reducing tea, the weight portion of each raw material is respectively blue berry 53 weight portion ~ 57 weight portion, Blue berry leaf 38 weight portion ~ 42 weight portion, Fructus Lycii 13 weight portion ~ 17 weight portion, Radix Puerariae 8 weight portion ~ 12 weight portion, Radix Et Caulis Acanthopanacis Senticosi 13 weight portion ~ 17 weight portion, Herba Visci 8 weight portion ~ 12 weight portion, Semen Myristicae 13 weight portion ~ 17 weight portion, Cortex Phellodendri 8 weight portion ~ 12 weight portion, Radix Liriopes 13 weight portion ~ 17 weight portion, Rhizoma Polygonati 8 weight portion ~ 12 weight portion, grass Radix Angelicae Pubescentis 8 weight portion ~ 12 weight portion, Semen Fagopyri Esculenti 13 weight portion ~ 17 weight portion, Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae) 8 weight portion ~ 12 weight portion, Herba Schisandrae intermediae 8 weight portion ~ 12 weight portion, Radix Hedysari 13 weight portion ~ 17 weight portion, Semen Euryales 8 weight portion ~ 12 weight portion, Herba Corydalis Bungeanae 13 weight portion ~ 17 weight portion, Herba Gerberae Piloselloidis 8 weight portion ~ 12 weight portion and Rhizoma Et Radix Notopterygii 13 weight portion ~ 17 weight portion.
Wherein, in described blue berry blood-sugar reducing tea, the weight portion of each raw material is respectively blue berry 55 weight portion, Blue berry leaf 40 weight portion, Fructus Lycii 15 weight portion, Radix Puerariae 10 weight portion, Radix Et Caulis Acanthopanacis Senticosi 15 weight portion, Herba Visci 10 weight portion, Semen Myristicae 15 weight portion, Cortex Phellodendri 10 weight portion, Radix Liriopes 15 weight portion, Rhizoma Polygonati 10 weight portion, careless Radix Angelicae Pubescentis 10 weight portion, Semen Fagopyri Esculenti 15 weight portion, Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae) 10 weight portion, Herba Schisandrae intermediae 10 weight portion, Radix Hedysari 15 weight portion, Semen Euryales 10 weight portion, Herba Corydalis Bungeanae 15 weight portion, Herba Gerberae Piloselloidis 10 weight portion and Rhizoma Et Radix Notopterygii 15 weight portion.
Present invention also offers the preparation method of above-mentioned blue berry blood-sugar reducing tea, it comprises:
The first step, the process of Blue berry leaf, the choosing of leaf is plucked after fruit harvest, and the leaf on the branch of predetermined beta pruning is plucked, and to carry out before blade reddens, clean after harvesting, then carry out the natural drying of 15 ~ 20h, dried blade is loaded cloth bag, 15min is rubbed with hand rubbing, then be placed in drying baker at 100 DEG C of temperature, dry 1h, is ground into powder subsequently;
Second step, the process of blue berry, after the fruit that granule is little, colour-difference can not be gone on the market is picked out, foreign material, cleaning, the drenches such as removing branch and leaf are done, are loaded refrigerator-freezer pre-freeze, pre-freezing temperature is-30 DEG C, drying, is chilled to-35 DEG C in advance by cold-trap, opens dry door, load the blue berry of deep colling, shut door, start vacuum pump set and find time, when vacuum reaches 60Pa, start heating, need in heating process to ensure stable working vacuum degree, and ensure that article maximum temperature is no more than 50 DEG C, average dehydration reaches 82.6%.
3rd step, prepares the effective extract component powder of Chinese herbal medicine;
4th step, by the Blue berry leaf powder that the first step obtains, the blue berry that second step obtains and the effective extract component powder of Chinese herbal medicine that the 3rd step obtains mix, and ultraviolet-sterilization is sterilized, and with Folium Camelliae sinensis bag splendid attire, obtain blue berry blood-sugar reducing tea.
Wherein, described 3rd step is specially further and each crude drug is ground into powder respectively according to above-mentioned weight portion, mixing, obtain mixed-powder, add with the water of mixed-powder total weight 3 ~ 8 times amount, decoct 2 hours, filter, add with the water of mixed-powder total weight 3 ~ 8 times amount in medicinal residues, decoct 2 hours, filter, merging filtrate, concentrated except anhydrating, be dried to powder.
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.
Embodiment 1 Chinese herbal medicine extracting powder
Each Fructus Lycii 15g, Radix Puerariae 10g, Radix Et Caulis Acanthopanacis Senticosi 15g, Herba Visci 10g, Semen Myristicae 15g, Cortex Phellodendri 10g, Radix Liriopes 15g, Rhizoma Polygonati 10g, careless Radix Angelicae Pubescentis 10g, Semen Fagopyri Esculenti 15g, Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae) 10g, Herba Schisandrae intermediae 10g, Radix Hedysari 15g, Semen Euryales 10g, Herba Corydalis Bungeanae 15g, Herba Gerberae Piloselloidis 10g and Rhizoma Et Radix Notopterygii 15g are ground into powder respectively, mixing, obtain mixed-powder, add the water of 1kg, decoct 2 hours, filter, the water of 1kg is added in medicinal residues, decoct 2 hours, filter, merging filtrate, concentrated except anhydrating, be dried to powder.
Embodiment 2 Chinese herbal medicine extracting powder
Each Fructus Lycii 12g, Radix Puerariae 7g, Radix Et Caulis Acanthopanacis Senticosi 12g, Herba Visci 7g, Semen Myristicae 12g, Cortex Phellodendri 7g, Radix Liriopes 12g, Rhizoma Polygonati 7g, careless Radix Angelicae Pubescentis 7g, Semen Fagopyri Esculenti 12g, Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae) 7g, Herba Schisandrae intermediae 7g, Radix Hedysari 12g, Semen Euryales 7g, Herba Corydalis Bungeanae 12g, Herba Gerberae Piloselloidis 7g and Rhizoma Et Radix Notopterygii 12g are ground into powder respectively, mixing, obtains mixed-powder, adds the water of 1kg, decoct 2 hours, filter, in medicinal residues, add the water of 1kg, decoct 2 hours, filter, merging filtrate, concentrated except anhydrating, be dried to powder.
Embodiment 3 Chinese herbal medicine extracting powder
Each Fructus Lycii 18g, Radix Puerariae 13g, Radix Et Caulis Acanthopanacis Senticosi 18g, Herba Visci 13g, Semen Myristicae 18g, Cortex Phellodendri 13g, Radix Liriopes 18g, Rhizoma Polygonati 13g, careless Radix Angelicae Pubescentis 13g, Semen Fagopyri Esculenti 18g, Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae) 13g, Herba Schisandrae intermediae 13g, Radix Hedysari 18g, Semen Euryales 13g, Herba Corydalis Bungeanae 18g, Herba Gerberae Piloselloidis 13g and Rhizoma Et Radix Notopterygii 18g are ground into powder respectively, mixing, obtain mixed-powder, add the water of 1kg, decoct 2 hours, filter, the water of 1kg is added in medicinal residues, decoct 2 hours, filter, merging filtrate, concentrated except anhydrating, be dried to powder.
Embodiment 4 blue berry blood-sugar reducing tea
The process of Blue berry leaf, the choosing of leaf is plucked after fruit harvest, leaf on the branch of predetermined beta pruning is plucked, and to carry out before blade reddens, clean after harvesting, then the natural drying of 15 ~ 20h is carried out, dried blade is loaded cloth bag, 15min is rubbed with hand rubbing, then drying baker is placed on interior at 100 DEG C of temperature, dry 1h, be ground into powder subsequently, the process of blue berry, granule is little, after the fruit that colour-difference can not be gone on the market is picked out, the foreign material such as removing branch and leaf, cleaning, drench is done, load refrigerator-freezer pre-freeze, pre-freezing temperature is-30 DEG C, dry, cold-trap is chilled to-35 DEG C in advance, open dry door, load the blue berry of deep colling, shut door, start vacuum pump set to find time, when vacuum reaches 60Pa, start heating, need in heating process to ensure stable working vacuum degree, and ensure that article maximum temperature is no more than 50 DEG C, average dehydration reaches 82.6%, by the Blue berry leaf powder 55g obtained above, the effective extract component powder of Chinese herbal medicine that blue berry 40g and embodiment 1 obtain mixes, ultraviolet-sterilization is sterilized, with Folium Camelliae sinensis bag splendid attire, obtain blue berry blood-sugar reducing tea.
Embodiment 5 toxicity detection
Acute toxicity testing
Test method: the blue berry blood-sugar reducing tea obtained with the embodiment of the present invention 4 is for object, and select 20 adult white mouse to test, the 30g of consumption per day, is immersed in the water decoction 1 hour, to 10 of test group white mouse gavages, observes 7.10 white mouse are all strong as a result deposits, and its activity, diet, hair, Excreta are no abnormal, have no toxic reaction.Toxicity test proves, the not toxic effect of this blood-sugar reducing tea and untoward reaction, clinical practice is safe and reliable.
Chronic toxicity test
Test method: with the blue berry blood-sugar reducing tea of the embodiment of the present invention 4 for object, get the identical rabbit of 80 ripe vital signs as object, male and female half-and-half, be 2 groups by its random division, 1 blank group and 1 test group, often organize 40, matched group is filled with and is fed water, the water that the blue berry blood-sugar reducing tea that test group gavage embodiment 4 obtains is soaked, consumption per day 5g, decocts 1 hour gavage in water.Medication carries out 30 days, by before comparing medication, the change such as behavior, the mental status, feces of medication 30 days and the rabbit of drug withdrawal after 30 days, carry out the toxicity detection of medicine.By observing the rabbit of test group, the rabbit after medicine feed, in behavior, the mental status and feces etc., with the rabbit of not offeing medicine, without any difference.Therefore, this medicine long-term taking, does not have cumulative toxicity, and can not deposit toxin in vivo.
Embodiment 6 animal effect experimental
Material: blue berry blood-sugar reducing tea prepared by embodiment 1
Reagent: metformin hydrochloride tablet (Beijing Sihuan Pharmaceutical Co., Ltd); Alloxan (Fluka product); Sodium chloride injection (0.9%, Siyao Co., Ltd., Shijiazhuang); Noradrenaline bitartrate (Shanghai He Feng pharmaceutical Co. Ltd); Chloroform, n-butyl alcohol, glucose, concentrated sulphuric acid are analytical pure.
Instrument: TU-1810 ultraviolet spectrophotometer (Beijing Puxi General Instrument Co., Ltd); PH meter PHB24 (Shanghai Precision Scientific Apparatus Co., Ltd); HH-4 type digital display thermostat water bath; 101A-3 type electric drying oven with forced convection; 800-B type desk centrifuge (Anting Scientific Instrument Factory, Shanghai); Electronic balance; Xi Beile pulverizer; SHZ-D circulating water type vacuum pump (Ying Yu Yu Hua instrument plant of Gongyi City), the superior blood-sugar detecting instrument of Roche, Roche sugar Test paper (Roche Diagnostics GmbH).Rotary evaporator RE252C (Shanghai Yarong Biochemical Instrument Plant).
Laboratory animal: Kun Ming mice, body weight 22 ~ 24g, male and female half and half.
Normal mouse experimental technique: get healthy mice 60, be divided into matched group, metformin hydrochloride group (125mg/kgd) and blue berry blood-sugar reducing tea group (200mg/kgd) at random, often organize 20, matched group gives equal-volume normal saline, every day gavage 1 time, continuous 14d, respectively at 5d, 7d, 14d after administration, eye socket gets blood, measures blood sugar level.
The blood sugar lowering of adrenaline-induced hyperglycosemia rats is tested: get healthy mice 80, be divided into Normal group at random, epinephrine group, metformin hydrochloride group (125mg/kgd) and blue berry blood-sugar reducing tea group (200mg/kgd), often organize 20, every day gastric infusion 1 time, Normal group and epinephrine group give normal saline (NS), and successive administration is after 2 weeks.12h fasting before last administration, after gastric infusion 2.0h except normal group injecting normal saline, all the other are all by 2mg/kg lumbar injection norepinephrine, and after 30min, eye socket gets blood, measure blood sugar level.
Alloxan is caused to the blood sugar lowering test of diabetic mice
Select healthy mice 80, fasting 12h pneumoretroperitoneum injection alloxan 200mg/kg, after 3d, fasting 5h, cut tail point and get blood survey blood glucose, filtering out fasting glucose the mice of more than 11.1mmol/L is diabetic mice, mice is divided into hyperglycemia model group at random, blue berry blood-sugar reducing tea group, medication therapy groups (metformin hydrochloride group) is positive controls, 0.9% normal saline is negative control group, often organize 20, blue berry blood-sugar reducing tea group presses the dosed administration of 400mg/kgd, metformin hydrochloride group presses the dosed administration of 125mg/kgd, hyperglycemia model group and the isopyknic normal saline of Normal group, administration every day 1 successive administration 2 weeks, 12h fasting before last administration, after last administration 2h, eye socket gets blood, measure blood sugar level.
The carbohydrate tolerance test of hyperglycemia model mice
Get alloxan and cause hyperglycemia model mice 60, be divided into 3 groups at random: hyperglycemia model group, medication therapy groups (metformin hydrochloride group) is positive controls, blue berry blood-sugar reducing tea group (200mg/kgd), often organizes 20.Getting 20 healthy mices is blue berry blood-sugar reducing tea group (200mg/kg), and medication, dosage are tested with adrenaline-induced hyperglycosemia rats.4 groups of mices process 14d continuously, and before the administration of last day, water 12h is can't help in fasting, after administration 3h, give glucose 2.5g/kg gavage, in 0,0.5,1.0, a 2.0h4 phase detects blood glucose with the superior blood-sugar detecting instrument of Roche respectively.Carry out carbohydrate tolerance experiment.
Mathematical statistics
Experimental data with mean+SD ( ± SD) represent, adopt SPSS15.0 software to carry out the analysis of single factor test variance statistic to data, group difference adopts Duncan multiple comparisons, and significant level is P<0.05.
Conclusion
On the impact of normal mouse blood sugar, the results are shown in Table 1.
Table 1 is on the impact of normal mouse blood sugar
After continuous gavage 14d, after normal mouse gavage polysaccharide, the blood glucose value of each time point of experimental session changes consistent with matched group blood glucose value, compares, nonsignificance with matched group.Metformin hydrochloride group then significantly reduces mice euglycemia (table 1).This shows, often taking blue berry blood-sugar reducing tea can not have an impact to the blood glucose value of normal mouse.
On the impact of adrenaline-induced hyperglycosemia rats blood glucose, the results are shown in Table 2.
Table 2 is on the impact of adrenaline-induced hyperglycosemia rats blood glucose
Group Dosage (mg/kg) Fasting blood sugar
Normal group NS 5.61 +0.92
Epinephrine model group NS 11.93 +1.17
Metformin hydrochloride group 125 7.93 +1.02
Blue berry blood-sugar reducing tea group 200 5.71 +0.83
Table 2 result shows, the blood glucose value of blue berry blood-sugar reducing tea group compares with epinephrine model group, extremely significantly (P<0.01), blood glucose value, close to normal mouse blood sugar level, shows that blue berry blood-sugar reducing tea group has the effect suppressing epinephrine induced mice blood glucose to raise to difference.
Table 3 causes the impact of hyperglycemia mouse blood sugar to alloxan
In table 3, result shows, after administration, the blood glucose value of blue berry blood-sugar reducing tea group compares with alloxan model group, and difference extremely significantly (P<0.01).Blue berry blood-sugar reducing tea group mice elevated blood glucose levels obtains and effectively controls, and can effectively reduce diabetic mice elevated blood glucose levels, not affect normal mouse blood sugar level.Result display blue berry blood-sugar reducing tea group can reduce experimental hyperglycemia mouse blood sugar.
Table 4 causes the impact of hyperglycemia glucose tolerance in mice to alloxan
Table 4 result shows, blue berry blood-sugar reducing tea group raises 1.0h and 2.0h blood glucose inhibitory action (P < 0.05).The mice of gavage polysaccharide 0,0.5,1.0,2.0h time blood glucose value compared with model group, reduce extremely significantly (P < 0.01), visible, the effect in the reduction of diabetes-alleviating glucose tolerance in mice of blue berry blood-sugar reducing tea group is remarkable, reaches the treatment level of medicine group.After normal mouse gavage polysaccharide, the blood glucose value when 0.5h is higher, along with passage of time, and 1.0,2.0h blood glucose value declines gradually, and tend to be steady.Illustrate that Anji Ramulus et Folium Mussaendae Pubescentis polysaccharide does not affect the carbohydrate tolerance of normal mouse.
All above-mentioned this intellectual properties of primary enforcement, not setting restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.
The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.

Claims (6)

1. a blue berry blood-sugar reducing tea, is characterized in that: raw material comprises blue berry, Blue berry leaf, Fructus Lycii, Radix Puerariae, Radix Et Caulis Acanthopanacis Senticosi, Herba Visci, Semen Myristicae, Cortex Phellodendri, Radix Liriopes, Rhizoma Polygonati, careless Radix Angelicae Pubescentis, Semen Fagopyri Esculenti, Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae), Herba Schisandrae intermediae, Radix Hedysari, Semen Euryales, Herba Corydalis Bungeanae, Herba Gerberae Piloselloidis and Rhizoma Et Radix Notopterygii.
2. blue berry blood-sugar reducing tea as claimed in claim 1, it is characterized in that: the weight portion of each raw material is respectively blue berry 50 weight portion ~ 60 weight portion, Blue berry leaf 35 weight portion ~ 45 weight portion, Fructus Lycii 10 weight portion ~ 20 weight portion, Radix Puerariae 5 weight portion ~ 15 weight portion, Radix Et Caulis Acanthopanacis Senticosi 10 weight portion ~ 20 weight portion, Herba Visci 5 weight portion ~ 15 weight portion, Semen Myristicae 10 weight portion ~ 20 weight portion, Cortex Phellodendri 5 weight portion ~ 15 weight portion, Radix Liriopes 10 weight portion ~ 20 weight portion, Rhizoma Polygonati 5 weight portion ~ 15 weight portion, grass Radix Angelicae Pubescentis 5 weight portion ~ 15 weight portion, Semen Fagopyri Esculenti 10 weight portion ~ 20 weight portion, Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae) 5 weight portion ~ 15 weight portion, Herba Schisandrae intermediae 5 weight portion ~ 15 weight portion, Radix Hedysari 10 weight portion ~ 20 weight portion, Semen Euryales 5 weight portion ~ 15 weight portion, Herba Corydalis Bungeanae 10 weight portion ~ 20 weight portion, Herba Gerberae Piloselloidis 5 weight portion ~ 15 weight portion and Rhizoma Et Radix Notopterygii 10 weight portion ~ 20 weight portion.
3. blue berry blood-sugar reducing tea as claimed in claim 2, it is characterized in that: the weight portion of each raw material is respectively blue berry 53 weight portion ~ 57 weight portion, Blue berry leaf 38 weight portion ~ 42 weight portion, Fructus Lycii 13 weight portion ~ 17 weight portion, Radix Puerariae 8 weight portion ~ 12 weight portion, Radix Et Caulis Acanthopanacis Senticosi 13 weight portion ~ 17 weight portion, Herba Visci 8 weight portion ~ 12 weight portion, Semen Myristicae 13 weight portion ~ 17 weight portion, Cortex Phellodendri 8 weight portion ~ 12 weight portion, Radix Liriopes 13 weight portion ~ 17 weight portion, Rhizoma Polygonati 8 weight portion ~ 12 weight portion, grass Radix Angelicae Pubescentis 8 weight portion ~ 12 weight portion, Semen Fagopyri Esculenti 13 weight portion ~ 17 weight portion, Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae) 8 weight portion ~ 12 weight portion, Herba Schisandrae intermediae 8 weight portion ~ 12 weight portion, Radix Hedysari 13 weight portion ~ 17 weight portion, Semen Euryales 8 weight portion ~ 12 weight portion, Herba Corydalis Bungeanae 13 weight portion ~ 17 weight portion, Herba Gerberae Piloselloidis 8 weight portion ~ 12 weight portion and Rhizoma Et Radix Notopterygii 13 weight portion ~ 17 weight portion.
4. blue berry blood-sugar reducing tea as claimed in claim 3, it is characterized in that: the weight portion of each raw material is respectively blue berry 55 weight portion, Blue berry leaf 40 weight portion, Fructus Lycii 15 weight portion, Radix Puerariae 10 weight portion, Radix Et Caulis Acanthopanacis Senticosi 15 weight portion, Herba Visci 10 weight portion, Semen Myristicae 15 weight portion, Cortex Phellodendri 10 weight portion, Radix Liriopes 15 weight portion, Rhizoma Polygonati 10 weight portion, grass Radix Angelicae Pubescentis 10 weight portion, Semen Fagopyri Esculenti 15 weight portion, Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae) 10 weight portion, Herba Schisandrae intermediae 10 weight portion, Radix Hedysari 15 weight portion, Semen Euryales 10 weight portion, Herba Corydalis Bungeanae 15 weight portion, Herba Gerberae Piloselloidis 10 weight portion and Rhizoma Et Radix Notopterygii 15 weight portion.
5. the preparation method of the blue berry blood-sugar reducing tea as described in Claims 1-4, is characterized in that, comprising:
The first step, the process of Blue berry leaf, the choosing of leaf is plucked after fruit harvest, and the leaf on the branch of predetermined beta pruning is plucked, and to carry out before blade reddens, clean after harvesting, then carry out the natural drying of 15 ~ 20h, dried blade is loaded cloth bag, 15min is rubbed with hand rubbing, then be placed in drying baker at 100 DEG C of temperature, dry 1h, is ground into powder subsequently;
Second step, the process of blue berry, after the fruit that granule is little, colour-difference can not be gone on the market is picked out, foreign material, cleaning, the drenches such as removing branch and leaf are done, are loaded refrigerator-freezer pre-freeze, pre-freezing temperature is-30 DEG C, drying, is chilled to-35 DEG C in advance by cold-trap, opens dry door, load the blue berry of deep colling, shut door, start vacuum pump set and find time, when vacuum reaches 60Pa, start heating, need in heating process to ensure stable working vacuum degree, and ensure that article maximum temperature is no more than 50 DEG C, average dehydration reaches 82.6%;
3rd step, prepares the effective extract component powder of Chinese herbal medicine;
4th step, by the Blue berry leaf powder that the first step obtains, the blue berry that second step obtains and the effective extract component powder of Chinese herbal medicine that the 3rd step obtains mix, and ultraviolet-sterilization is sterilized, and with Folium Camelliae sinensis bag splendid attire, obtain blue berry blood-sugar reducing tea.
6. the preparation method of blue berry blood-sugar reducing tea according to claim 5, is characterized in that: described 3rd step is specially further and each crude drug is ground into powder respectively according to above-mentioned weight portion, mixing, obtain mixed-powder, add with the water of mixed-powder total weight 3 ~ 8 times amount, decoct 2 hours, filter, add with the water of mixed-powder total weight 3 ~ 8 times amount in medicinal residues, decoct 2 hours, filter, merging filtrate, concentrated except anhydrating, be dried to powder.
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* Cited by examiner, † Cited by third party
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CN108685964A (en) * 2018-07-12 2018-10-23 贵州医科大学 The application of pilose gerbera herb extract and its active principle preparation method
CN108887441A (en) * 2018-09-06 2018-11-27 刘长成 A kind of health protection tea and preparation method thereof

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CN108685964A (en) * 2018-07-12 2018-10-23 贵州医科大学 The application of pilose gerbera herb extract and its active principle preparation method
CN108887441A (en) * 2018-09-06 2018-11-27 刘长成 A kind of health protection tea and preparation method thereof

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