CN111888431A

CN111888431A - Composition for treating diabetes and preparation method thereof

Info

Publication number: CN111888431A
Application number: CN202010824440.4A
Authority: CN
Inventors: 黄斌
Original assignee: Jiangxi Youpei Culture Media Co ltd
Current assignee: Jiangxi Youpei Culture Media Co ltd
Priority date: 2020-08-17
Filing date: 2020-08-17
Publication date: 2020-11-06

Abstract

A composition for the treatment of diabetes comprises selenium-rich tea, radix Panacis Quinquefolii, radix Puerariae, fructus crataegi, rhizoma Polygonati, lalang grass rhizome, fructus Lycii, Bulbus Lilii, Germinatus Phragmitis, Spirulina, flos Sophorae Immaturus, testa Tritici, exocarpium Citrulli, fructus Rosae Normalis extract, fructus Momordicae Charantiae extract, and herba Spinaciae extract. The raw materials for preparing the active ingredients of the traditional Chinese medicine composition are reasonable and scientific in compatibility, the drug effects complement each other, a good synergistic effect can be generated, and the prepared product has the effects of remarkably reducing blood sugar and blood fat, so that the aim of treating diabetes is fulfilled.

Description

Composition for treating diabetes and preparation method thereof

Technical Field

The invention relates to the field of traditional Chinese medicines, in particular to a composition for treating diabetes and a preparation method thereof.

Background

Diabetes is a group of metabolic diseases characterized by hyperglycemia. Hyperglycemia is caused by a defect in insulin secretion or an impaired biological action, or both. Hyperglycemia occurring in the long term of diabetes results in chronic damage to, and dysfunction of, various tissues, particularly the eyes, kidneys, heart, blood vessels, nerves. With the development of social economy, the living standard of people is continuously improved, the diabetic patients in China tend to increase year by year and have a youthful trend, the diabetic patients are often obese and have the symptoms of hyperlipidemia and hyperglycemia, no method for radically treating diabetes exists at present, but the diabetes can be well controlled by various treatment means. The main mechanisms of reducing blood sugar are to increase the utilization of peripheral tissues to glucose, increase the anaerobic glycolysis of glucose, reduce the absorption of glucose by gastrointestinal tracts and reduce the weight. The product is a Chinese patent medicine developed for treating diabetes by aiming at the phenomenon. Can better regulate blood sugar, reduce blood fat and reduce weight, thereby controlling the blood sugar of a human body to be normal.

Disclosure of Invention

The invention aims to provide a health care medicine which has reasonable and scientific raw material compatibility for preparing active ingredients of the medicine, can solve the problem of high blood sugar and blood fat of the diabetes patients at present and enables the blood sugar index to reach the normal range.

The technical scheme of the invention is realized as follows:

a composition for treating diabetes comprises the following raw materials as active ingredients in parts by weight:

the active ingredients of the composition are prepared from the following raw materials in parts by weight:

30-50 parts of selenium-rich tea, 15-20 parts of American ginseng, 30-50 parts of kudzu root, 30-50 parts of hawthorn, 30-50 parts of rhizoma polygonati, 30-50 parts of cogongrass rhizome, 25-35 parts of medlar, 20-30 parts of lily, 20-30 parts of asparagus, 15-25 parts of spirulina, 10-15 parts of sophora flower, 30-50 parts of wheat bran, 30-50 parts of watermelon peel, 10-15 parts of rosa roxburghii fruit extract, 8-15 parts of bitter gourd extract and 8-15 parts of spinach extract.

The preparation method comprises the following steps:

(1) 30-50 parts of selenium-rich tea, 15-20 parts of American ginseng, 30-50 parts of kudzu root, 30-50 parts of hawthorn, 30-50 parts of rhizoma polygonati, 30-50 parts of lalang grass rhizome, 25-35 parts of medlar, 20-30 parts of lily, 20-30 parts of asparagus, 30-50 parts of wheat bran and 30-50 parts of watermelon peel are decocted for 2 times, 2 hours each time, 8 times of purified water is added for the first time, 6 times of purified water is added for the second time, low-temperature extraction is carried out, filtrates are combined, filtered and concentrated to obtain an extract with the relative density of 1.1-1.2 and the temperature of 60 ℃, diluted and extracted by 6 times of 95% ethanol, ethanol is recovered, concentrated to obtain an alcohol extract with the relative density of 1.1-1.2 and the temperature of 60 ℃, and the alcohol extract is dried;

(2) mixing 15-25 parts of spirulina and 10-15 parts of sophora flower, and crushing into fine powder for later use;

(3) uniformly mixing 10-15 parts of roxburgh rose fruit extract, 8-15 parts of bitter gourd extract and 8-15 parts of spinach extract for later use;

(4) mixing (1), (2) and (3), granulating, and drying to obtain granule.

The botanical drug materials used in the present invention:

selenium-rich tea: the anti-aging effect of the selenium-rich tea on the human body is mainly reflected in the coordination of a plurality of effective chemical components and a plurality of vitamins, particularly tea polyphenol, caffeine, vitamin C, aromatic substances, lipopolysaccharide and the like, and the selenium-rich tea can enhance the activity of cardiac muscle and the elasticity of blood vessels of the human body, inhibit arteriosclerosis, reduce the incidence rate of hypertension and coronary heart disease, enhance immunity, thereby resisting aging and prolonging the life of people. According to the medical research, the tea polyphenol can reduce the contents of cholesterol and triglyceride in blood, enhance the toughness and elasticity of capillaries and reduce blood fat, and is very useful for preventing and treating hypertension, cardiovascular diseases and other common diseases of middle-aged and elderly people. The selenium-rich tea contains selenium element and is organic selenium which is easier to be absorbed by people than selenium in grain and oil, and the American Rickett Paisha considers that the food is added with selenium, vitamin C and vitamin E to form a mixture, so that the life of people can be prolonged, and the selenium-rich tea is rich in the exotic elements which are beneficial to life. The selenium-rich tea has good effect of regulating blood fat of diabetics.

American ginseng: has effects in invigorating qi, nourishing blood, replenishing vital essence, invigorating kidney, invigorating spleen, nourishing stomach, delaying aging, and caring skin. Modern medical research proves that the American ginseng has the effects of resisting fatigue, aging and shock, improving thinking, improving memory, regulating endocrine, enhancing human immunity, improving cardiovascular function and the like. Pharmacological research shows that the American ginseng can effectively promote the secretion of insulin in vivo after being taken, and has very obvious effect of balancing the blood sugar value in vivo. Meanwhile, the American ginseng is beneficial to promoting fat metabolism in the body and can help the body to achieve a good weight-losing and slimming effect.

Kudzu root: has effects in promoting salivation, quenching thirst, and lowering blood sugar.

Hawthorn fruit: has effects of reducing blood lipid and lowering blood pressure.

Rhizoma polygonati: the sealwort contains aspartic acid, homoserine, quinones, cardiac glycoside and the like, so that the sealwort can help people to well reduce blood pressure, is very helpful for increasing blood flow of coronary arteries, has obvious effect on inhibiting blood sugar and urine sugar, and is particularly suitable for diabetes patients and people with chronic diseases to condition bodies because of hyperglycemia caused by epinephrine.

Cogongrass rhizome: has effects in promoting salivation, quenching thirst, and treating diabetes.

Medlar: tonify kidney, replenish vital essence, nourish liver to improve vision, enrich blood and tranquilize mind, promote the production of body fluid to quench thirst, moisten lung to arrest cough. Fructus Lycii has effects in regulating immunity, inhibiting tumor growth and cell mutation, delaying aging, preventing fatty liver, regulating blood lipid and blood sugar, and promoting hematopoiesis. The water extract of fructus Lycii (20%, 8 ml/day) has effects of slightly inhibiting fat deposition in liver cell and promoting liver cell regeneration for mouse poisoned by carbon tetrachloride. The water extract also has effect in preventing carbon tetrachloride-induced liver function disorder (activity of cholinesterase and transaminase is used as index). If the water extract or betaine of fructus Lycii is orally administered to rat for a long period (75 days), phospholipid level in blood and liver can be increased; the content of phospholipid and total cholesterol in liver of rat poisoned by carbon tetrachloride is reduced, and the content of betaine or water extract of Chinese wolfberry is increased in advance or simultaneously; meanwhile, the composition has an improvement effect on tests such as BSP, SGPT, alkaline phosphatase, cholinesterase and the like. The action of lycium barbarum on lipid metabolism or lipotropism is mainly caused by the betaine contained therein, which acts as a methyl donor in vivo. Researches find that the polysaccharide contained in the wolfberry can play a good role in protecting the liver and kidney of people, and is good for repairing the liver injury. Since he can effectively reduce the conversion of serum gluten in the body to ammonia enzymes, the renal function will naturally be well-restored. In addition, the medlar can effectively inhibit the deposition of fat in the body in liver cells, so the medlar also has the effect of promoting the regeneration of the liver cells and other cells of the body.

Lily: in traditional Chinese medicine, lily is used as a tonic for stopping bleeding, promoting blood circulation, clearing away lung-heat, moistening dryness, nourishing yin, clearing heat, regulating spleen and invigorating stomach. Lily is preferred for use as a medicine, especially for wild one, sweet and slightly bitter in taste, slightly cold in nature, and suitable for the heart and lung meridians, especially for the tonification. Modern researches show that lily has obvious effects of regulating blood fat, lowering blood pressure and the like, improving lymphocyte transformation rate and increasing the activity of liquid immunologic function.

Asparagus: has effects in relieving swelling, promoting urination, enhancing immunity, reducing blood lipid, and reducing weight.

Spirulina: has effects in regulating blood sugar, relieving fatigue, and protecting intestine and stomach.

Flos Sophorae Immaturus, bitter and cold in property, and has effects of cooling blood and stopping bleeding, and is suitable for bleeding of lower energizer, hematochezia and hemorrhoidal bleeding; flos Sophorae Immaturus has effects of clearing liver-fire and purging pathogenic fire, and has definite therapeutic effect on dizziness, headache and giddiness due to liver fire flaming up or liver yang hyperactivity. Modern pharmacological and ingredient researches show that the sophora japonica can protect blood vessels, and mainly rutin in the sophora japonica can reduce the fragility of the blood vessels, assist in treating hypertension and reduce the stroke risk of hypertension patients.

Wheat bran: has the functions of removing heat, quenching thirst, arresting sweating and reducing swelling. The medicines are used for treating diabetes.

Watermelon peel: has effects in promoting urination, relieving swelling, clearing away summer-heat, removing toxic materials, and removing miliaria, and can be used for treating diabetes.

Rosa roxbunghii fruit extract: the Rosa roxburghii Tratt juice can increase superoxide dismutase (SOD), reduce Lipid Peroxide (LPO) content, remarkably enhance immunity of rat and mouse, accelerate excretion of lead, manganese, cadmium, arsenic, mercury, etc., and reduce in vivo content, thereby playing a role in removing toxic substances to heavy metals. The effect is the result of the synergistic effect of SOD, polysaccharide of Rosa roxburghii Tratt, vitamin C, microelement and other active ingredients, and flavone of Rosa roxburghii Tratt can remarkably reduce serum glucose and triglyceride, and increase serum insulin, thereby having the effects of protecting pancreas and preventing diabetes. It has also been reported that vitamin F, an active ingredient in Rosa roxburghii Tratt, is a flavonoid compound, has a structure similar to that of quercetin, and thus has the effect of inhibiting aldose reductase and can alleviate and prevent diabetic lesions and complications.

The bitter gourd extract: is praised as plant insulin, and has the medicinal and health-care functions of reducing blood sugar, reducing blood fat, resisting tumor, preventing osteoporosis, regulating endocrine, resisting oxidation and bacteria, improving human immunity and the like.

Spinach extract: has effects in lowering blood sugar and relieving diabetes.

The materials are matched, the drug effects complement each other, the blood sugar and the blood fat can be reduced by synchronous conditioning, and the purpose of treating diabetes is achieved. The invention can be used together with other hypoglycemic drugs and insulin, thereby enhancing the treatment effect and enhancing the immunity of the organism.

Compared with the prior art, the invention has the advantages that: 1. the raw materials for preparing the active ingredients of the traditional Chinese medicine composition are reasonable and scientific in compatibility, the drug effects complement each other, a good synergistic effect can be generated, and the prepared product has the effects of remarkably reducing blood sugar and blood fat, so that the aim of treating diabetes is fulfilled; 2. the preparation technology is advanced, the extraction raw material essence is adopted for concentration, and the content of the effective components is high; 3. the production process is simple, and the production cost is reduced; 4. all the raw materials can be used as medicines and foods, are safe, have no side effect, are beneficial to absorption, can be taken for a long time, can adjust the dosage according to the condition of an illness, and can not cause hypoglycemia because the blood sugar is reduced below a normal value due to over-dosage like some western medicines.

Detailed Description

In order that the objects, features, advantages and effects achieved by the present invention will be readily apparent and fully understood, specific embodiments of the present invention will be described.

The first embodiment is as follows:

the composition for treating diabetes and the preparation method thereof comprise the following active ingredients in parts by weight: 30 parts of selenium-rich tea, 15 parts of American ginseng, 30 parts of kudzuvine root, 30 parts of hawthorn, 30 parts of rhizoma polygonati, 30 parts of cogongrass rhizome, 25 parts of medlar, 20 parts of lily, 20 parts of asparagus, 15 parts of spirulina, 10 parts of sophora flower, 30 parts of wheat bran, 30 parts of watermelon peel, 10 parts of rosa roxburghii fruit extract, 8 parts of bitter gourd extract and 8 parts of spinach extract.

The preparation method comprises the following steps:

(1) adding 8 times of purified water into 30 parts of selenium-rich tea, 15 parts of American ginseng, 30 parts of kudzu root, 30 parts of hawthorn, 30 parts of rhizoma polygonati, 30 parts of lalang grass rhizome, 25 parts of medlar, 20 parts of lily, 20 parts of asparagus, 30 parts of wheat bran and 30 parts of watermelon peel for the first time, adding 6 times of purified water for the second time, extracting at low temperature, combining filtrates, filtering, concentrating to obtain an extract with a relative density of 1.1-1.2 and a temperature of 60 ℃, diluting and extracting with 6 times of 95% ethanol, recovering ethanol, concentrating to obtain an ethanol extract with a relative density of 1.1-1.2 and a temperature of 60 ℃, drying, and kneading into fine powder for later use;

(2) mixing and crushing 15 parts of spirulina and 10 parts of sophora flower into fine powder for later use;

(3) uniformly mixing 10 parts of the rosa roxburghii tratt fruit extract, 8 parts of the bitter gourd extract and 8 parts of the spinach extract for later use;

(4) mixing (1), (2) and (3), granulating, and drying to obtain granule.

Example two:

the composition for treating diabetes and the preparation method thereof comprise the following active ingredients in parts by weight: 50 parts of selenium-rich tea, 20 parts of American ginseng, 50 parts of kudzuvine root, 50 parts of hawthorn, 50 parts of rhizoma polygonati, 50 parts of cogongrass rhizome, 35 parts of medlar, 30 parts of lily, 30 parts of asparagus, 25 parts of spirulina, 15 parts of sophora flower, 50 parts of wheat bran, 50 parts of watermelon peel, 15 parts of rosa roxburghii fruit extract, 15 parts of bitter gourd extract and 15 parts of spinach extract.

The preparation method comprises the following steps:

(1) 50 parts of selenium-rich tea, 20 parts of American ginseng, 50 parts of kudzuvine root, 50 parts of hawthorn, 50 parts of rhizoma polygonati, 50 parts of cogongrass rhizome, 35 parts of medlar, 30 parts of lily, 30 parts of asparagus, 50 parts of wheat bran and 50 parts of watermelon peel are added with 8 times of purified water for the first time and 8 times of purified water for the second time, the filtrate is combined, filtered and concentrated to an extract with the relative density of 1.1-1.2 and the temperature of 60 ℃, diluted and extracted by 6 times of 95% ethanol, the ethanol is recovered, concentrated to an ethanol extract with the relative density of 1.1-1.2 and the temperature of 60 ℃, dried and kneaded into fine powder for later use;

(2) mixing and crushing 25 parts of spirulina and 15 parts of sophora flower into fine powder for later use;

(3) uniformly mixing 15 parts of the rosa roxburghii tratt fruit extract, 15 parts of the bitter gourd extract and 15 parts of the spinach extract for later use;

(4) mixing (1), (2) and (3), granulating, and drying to obtain granule.

Example three:

the composition for treating diabetes and the preparation method thereof comprise the following active ingredients in parts by weight: 40 parts of selenium-rich tea, 18 parts of American ginseng, 40 parts of kudzuvine root, 40 parts of hawthorn, 40 parts of rhizoma polygonati, 40 parts of cogongrass rhizome, 30 parts of medlar, 25 parts of lily, 25 parts of asparagus, 20 parts of spirulina, 12 parts of sophora flower, 40 parts of wheat bran, 40 parts of watermelon peel, 12 parts of rosa roxburghii fruit extract, 10 parts of bitter gourd extract and 10 parts of spinach extract.

The preparation method comprises the following steps:

(1) decocting 40 parts of selenium-rich tea, 18 parts of American ginseng, 40 parts of kudzuvine root, 40 parts of hawthorn, 40 parts of rhizoma polygonati, 40 parts of cogongrass rhizome, 30 parts of medlar, 25 parts of lily, 25 parts of asparagus, 40 parts of wheat bran and 40 parts of watermelon peel with purified water for 2 times, adding 9 times of purified water for the first time and 7 times of purified water for the second time, extracting at low temperature, combining filtrates, filtering, concentrating to obtain an extract with the relative density of 1.1-1.2 and the temperature of 60 ℃, diluting and extracting with 6 times of 95% ethanol, recovering ethanol, concentrating to obtain an alcohol extract with the relative density of 1.1-1.2 and the temperature of 60 ℃, drying and kneading into fine powder for later use;

(2) mixing and crushing 20 parts of spirulina and 12 parts of sophora flower into fine powder for later use;

(3) uniformly mixing 12 parts of rosa roxburghii tratt fruit extract, 10 parts of bitter gourd extract and 10 parts of spinach extract for later use;

(4) mixing (1), (2) and (3), granulating, and drying to obtain granule.

The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents, improvements and the like that fall within the spirit and principle of the present invention are intended to be included therein.

Claims

1. The composition for treating diabetes is characterized by being prepared from the following active ingredients in parts by weight: 30-50 parts of selenium-rich tea, 15-20 parts of American ginseng, 30-50 parts of kudzu root, 30-50 parts of hawthorn, 30-50 parts of rhizoma polygonati, 30-50 parts of cogongrass rhizome, 25-35 parts of medlar, 20-30 parts of lily, 20-30 parts of asparagus, 15-25 parts of spirulina, 10-15 parts of sophora flower, 30-50 parts of wheat bran, 30-50 parts of watermelon peel, 10-15 parts of rosa roxburghii fruit extract, 8-15 parts of bitter gourd extract and 8-15 parts of spinach extract.

2. The composition for treating diabetes according to claim 1, which is prepared from the following active ingredients in parts by weight: 30 parts of selenium-rich tea, 15 parts of American ginseng, 30 parts of kudzuvine root, 30 parts of hawthorn, 30 parts of rhizoma polygonati, 30 parts of cogongrass rhizome, 25 parts of medlar, 20 parts of lily, 20 parts of asparagus, 15 parts of spirulina, 10 parts of sophora flower, 30 parts of wheat bran, 30 parts of watermelon peel, 10 parts of rosa roxburghii fruit extract, 8 parts of bitter gourd extract and 8 parts of spinach extract.

3. The composition for treating diabetes according to claim 1, which is prepared from the following active ingredients in parts by weight: 50 parts of selenium-rich tea, 20 parts of American ginseng, 50 parts of kudzuvine root, 50 parts of hawthorn, 50 parts of rhizoma polygonati, 50 parts of cogongrass rhizome, 35 parts of medlar, 30 parts of lily, 30 parts of asparagus, 25 parts of spirulina, 15 parts of sophora flower, 50 parts of wheat bran, 50 parts of watermelon peel, 15 parts of rosa roxburghii fruit extract, 15 parts of bitter gourd extract and 15 parts of spinach extract.

4. The composition for treating diabetes according to claim 1, which is prepared from the following active ingredients in parts by weight: 40 parts of selenium-rich tea, 18 parts of American ginseng, 40 parts of kudzuvine root, 40 parts of hawthorn, 40 parts of rhizoma polygonati, 40 parts of cogongrass rhizome, 30 parts of medlar, 25 parts of lily, 25 parts of asparagus, 20 parts of spirulina, 12 parts of sophora flower, 40 parts of wheat bran, 40 parts of watermelon peel, 12 parts of rosa roxburghii fruit extract, 10 parts of bitter gourd extract and 10 parts of spinach extract.

5. The method of preparing a composition for treating diabetes according to claims 1-4, comprising the steps of:

(1) weighing selenium-rich tea, American ginseng, kudzu vine root, hawthorn, rhizoma polygonati, lalang grass rhizome, medlar, lily, asparagus, wheat bran and watermelon peel according to the weight, decocting the selenium-rich tea, the American ginseng, the kudzu vine root, the hawthorn, the rhizoma polygonati, the lalang grass rhizome, the medlar, the lily, the asparagus, the wheat bran and the watermelon peel with purified water for 2 times, 2 hours each time, adding 8 times of purified water for the first time and 6 times of purified water for the second time, extracting at low temperature, combining filtrates, filtering, concentrating to obtain an extract with the relative density of 1.1-1.2 and the temperature of 60 ℃, diluting and extracting with 6 times of 95% ethanol, recovering the ethanol, concentrating to obtain an ethanol extract with;

(2) mixing Spirulina and flos Sophorae Immaturus, and pulverizing into fine powder;

(3) uniformly mixing the roxburgh rose fruit extract, the bitter gourd extract and the spinach extract for later use;

(4) and (3) uniformly mixing the substances obtained in the steps (1), (2) and (3), granulating, and drying to obtain granules.