CN103750107B - Health-care product with blood glucose reducing function - Google Patents
Health-care product with blood glucose reducing function Download PDFInfo
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- CN103750107B CN103750107B CN201410034619.4A CN201410034619A CN103750107B CN 103750107 B CN103750107 B CN 103750107B CN 201410034619 A CN201410034619 A CN 201410034619A CN 103750107 B CN103750107 B CN 103750107B
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/30—Foods or foodstuffs containing additives; Preparation or treatment thereof containing carbohydrate syrups; containing sugars; containing sugar alcohols, e.g. xylitol; containing starch hydrolysates, e.g. dextrin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Nutrition Science (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention discloses a health-care product with a blood glucose reducing function. The health-care product is prepared from the following raw material components in parts by weight: 10-20 parts of semen coicis extracts, 10-15 parts of euonymus alatus extracts, 8-10 parts of astragalus polysaccharides, 5-8 parts of corn stigma aqueous extracts and 3-5 parts of lycium barbarum polysaccharide. The extracts of all the components are prepared according to a composite formula in which semen coicis, euonymus alatus, astragalus, corn stigma and lycium barbarum which all have a better blood glucose reducing effect are scientifically selected, so that the blood glucose reducing components are enriched, the effect of the health-care product regulating diabetes can be enhanced, and the health-care product can also be used for effectively preventing, treating and relieving the happen and development of diabetic complications and is suitable for being taken by diabetic patients for a long term.
Description
Technical field
The present invention is specifically related to a kind of health products with function of polysaccharide.
Background technology
Diabetes be one group caused by body defect of insulin secretion and/or insulin action obstacle, take hyperglycaemia as the metabolic disease of principal character.Persistent high blood sugar and long-term metabolic disorder etc. can cause body tissue's organ, particularly to eye, kidney, cardiovascular and neural infringement and dysfunction thereof and exhaustion, severe patient can cause dehydration, the acute complications such as electrolyte disturbance and acid-base imbalance, DKA and Hyperosmotic coma, all cause great harm to the physiology of patient and psychology.In addition, no matter be IDDM or type II diabetes, all need long-term treatment, this brings heavy financial burden also to patient and family members thereof.
China is one of diabetes country occurred frequently, and national diabetic about 100,000,000, therefore how to reduce blood sugar, controls and one of problem that the various symptoms that diabetes-alleviating causes are modern people to be paid close attention to the most.Coix seed is grass Job's tears
coix lacryma-jobi L. var. meyuan(
romen.) the kind benevolence of Stapf, cool in nature, taste is sweet, light, and having wet, main effect of quenching one's thirst, is one of common drug of traditional Chinese medicine clinical treatment diabetes.Containing several functions active components such as coixan, coixenolide and distinctive triterpene compounds in coix seed.Clinical trial shows, coixan, as one of coix seed main active, has significant hypoglycemic activity, has good effect, can treat diabetic vascular complications and flat wart, molluscum contagiosum in Tumor suppression, raising immunity function etc.; Coixenolide is the derivative of unrighted acid, and it is mainly triglycerides containing alcohol moiety, has analgesia, hypoglycemic effect.Ramulus euonymi has another name called winged euonymus, is Celastraceae plant winged euonymus
euonymus alatus(
thunb.) branch of fin of Sieb or aliform adjunct, cold in nature, bitter, pungent, there is effect of broken blood, dysmenorrhoea, desinsection, blood stasis removing analgesic.Namely Ramulus euonymi folk prescription uses has good blood sugar decreasing effect, shows after deliberation, its blood sugar reducing function may with stimulate insulin secretion, improve the affinity of insulin and acceptor, improve the function of the β cell of damaged, reduction body is to the antagonism of insulin.The Radix Astragali is legume astragalus mongolicus
astragalus membranaceus(
fich.) Bunge and Inner Mongolia Astragalis
a. mongholicusbge. root, taste is sweet, slightly warm in nature, has invigorating qi for consolidating superficies, effect of inducing diuresis for removing edema.The Radix Astragali can promote organism metabolism, and reduce the activity of aldose reductase, delay the development of diabetes, the astragalus polyose contained by it also can increase insulin sensitivity, thus plays reduction blood sugar, the effect of control diabetic complication.Corn stigma is style and the column cap of grass maize ZeamaysL., and taste is sweet, and property is put down, and has effect of calming liver and clearing heat, diuresis clearing damp.By its to boil water take to play reduce the effect of blood fat, blood pressure and blood sugar, therefore can be used as hypoglycemic medicine and use.Matrimony vine is plant of Solanaceae lycium barbarum
lycium barbaruml. dry mature fruit, taste is sweet, and property is put down, and has effect that is nourishing liver and kidney, benefiting shrewd head.Modern study shows, the LBP-X contained by matrimony vine is by protection beta Cell of islet and increase insulin sensitivity double action and play hypoglycemic effect.
Summary of the invention
The object of the present invention is to provide a kind of health products with function of polysaccharide, the good coix seed of hypoglycemic effect, Ramulus euonymi, the Radix Astragali, corn stigma and matrimony vine composition compound prescription is chosen by science, prepare each component extract, make its hypoglycemic activity composition obtain enrichment, the effect of its regulation and control diabetes can be strengthened.
For achieving the above object, the present invention adopts following technical scheme:
There are health products for function of polysaccharide, comprise the raw material of following weight portion: Semen Coicis extract 10 ~ 20 parts, Ramulus euonymi extract 10 ~ 15 parts, astragalus polyose 8 ~ 10 parts, corn silk water extract 5 ~ 8 parts, LBP-X 3 ~ 5 parts.
The preparation method of described Semen Coicis extract comprises the following steps:
1) pulverize: the coix seed of drying pulverized and crosses 100 mesh sieves, obtaining coix seed powder;
2) first time alcohol extracting: be that the ethanolic solution of 80% ~ 90% is as extract using mass fraction, coix seed powder and ethanolic solution are fed intake by mass volume ratio 1:5 ~ 6, first coix seed powder is soaked 12 hours in ethanolic solution, extract 1 hour under 65 DEG C of conditions again, leave standstill, collecting supernatant is first time extract;
3) second time alcohol extracting: be that the ethanolic solution of 65% is as extract using mass fraction, by coix seed powder: the mass ratio of ethanol=1:5 ~ 6 is to step 2) in add ethanolic solution in remaining residue, extract 2 hours under 65 DEG C of conditions again, leave standstill, collect supernatant i.e. second time extract;
4) water extraction is got: by coix seed powder: the mass volume ratio of water=1:8 adds water in remaining residue in step 3), then extracts 2 hours under 100 DEG C of conditions, filters, and collects third time extract;
5) extract concentrates: by No. three extract mixing, and carry out Vacuum Concentration;
6) spraying dry: concentrate is carried out spraying dry, obtains Semen Coicis extract.
The preparation method of described Ramulus euonymi extract comprises the following steps:
1) alcohol extract: get dry Ramulus euonymi medicinal material, be that the ethanolic solution of 80% ~ 90% is as extract using mass fraction, Ramulus euonymi and ethanolic solution are fed intake by mass volume ratio 1:6 ~ 8, heating and refluxing extraction 2 times, each extraction 0.5 ~ 1 hour, leave standstill, collect supernatant and ethanol extract respectively;
2) water extraction is got: by Ramulus euonymi: water=1:8 ~ 10 volume ratio adds water in remaining residue in step 1, then extracts 2 hours under 100 DEG C of conditions, filters, and collects aqueous extract;
5) extract concentrates: by No. three extract mixing, and carry out Vacuum Concentration;
6) spraying dry: concentrate is carried out vacuum drying, obtains Ramulus euonymi extract.
The preparation method of described astragalus polyose comprises the following steps:
1) pulverize: the Radix Astragali pulverized and crosses 100 mesh sieves, obtaining astragalus membranaceus powder;
2) water extraction is got: by astragalus membranaceus powder: the mass ratio of water=1:10 adds water, then extracts 2 hours under 100 DEG C of conditions, filters, collects extract;
3) enzyme reaction: solution cellulase being mixed with 50 U/mL, by extract: the volume ratio of cellulase solution=5:1 adds cellulase solution, adjust ph is 5.5 ~ 6.2, and reaction temperature controls at 30 ~ 38 DEG C, reaction 60 ~ 80 min;
4) polysaccharide precipitation: by the extract after enzyme reaction process through 3000 ~ 3500rpm high speed centrifugation 10 min, collects lower floor's polysaccharide precipitation;
5) dry: the polysaccharide precipitation obtained to be carried out spraying dry, obtains astragalus polyose.
Described Corn silk P.E is after being cleaned by corn stigma, and to add water refluxing extraction 2 times by mass volume ratio 1:2 ~ 4, each 30 ~ 60 min, collect extracted twice liquid, freeze drying obtains Corn silk P.E.
Described LBP-X is after being cleaned by matrimony vine, and to add water Microwave Extraction 2 times by mass volume ratio 1:10, extract 20 ~ 30 min, microwave power 450 ~ 500 W, collect extracted twice liquid, spraying dry obtains LBP-X at every turn.
Dried Semen Coicis extract, Ramulus euonymi extract, astragalus polyose, Corn silk P.E and LBP-X are added appropriate amount of auxiliary materials by the described preparation method with the health products of function of polysaccharide, obtain electuary, granule, capsule or tablet with common process.
Coix seed: taste is sweet, light, cool in nature, has invigorating the spleen excreting dampness, effect except numbness antidiarrheal.Coixenolide contained in coix seed and coixan are its main active.Research shows, there is good effect the aspects such as coixan Tumor suppression, raising immunity function, also have significant hypoglycemic activity, can treat diabetic vascular complications; Coixenolide is the derivative of unrighted acid, and its triglycerides containing alcohol moiety also has analgesia, hypoglycemic effect.
Ramulus euonymi: bitter, pungent, cold in nature, has that promoting circulation of blood is stimulated the menstrual flow, effect of blood stasis removing analgesic, can treat the various disease conditions such as diabetes, hyperlipidemia.Recent study shows, the water extraction position of Ramulus euonymi and alcohol extracting position all have higher reduction blood sugar, improve the effect of sugar tolerance, and this may be higher relevant with the flavones ingredient content at the polysaccharide component at water extraction position and alcohol extracting position.
The Radix Astragali: taste is sweet, slightly warm in nature, has invigorating qi for consolidating superficies, effect of inducing diuresis for removing edema.Report display, the Radix Astragali can promote organism metabolism, and reduce the activity of aldose reductase, delay the development of diabetes, the astragalus polyose contained by it also can increase insulin sensitivity, thus plays reduction blood sugar, the effect of control diabetic complication.
Corn stigma: taste is sweet, property is put down, and has effect of calming liver and clearing heat, diuresis clearing damp, can be used for disease such as treatment hypertension, diabetes etc.The effect can played and reduce blood fat, blood pressure and blood sugar is taken by boil water for corn stigma.
Matrimony vine: taste is sweet, the diseases such as property is put down, and has effect that is nourishing liver and kidney, benefiting shrewd head, smart thanks to for consumptive disease, interior heat is quenched one's thirst, the deficiency of blood is sallow.Modern study shows, the LBP-X contained by matrimony vine is by protection beta Cell of islet and increase insulin sensitivity double action and play hypoglycemic effect.
remarkable advantage of the present invention is:the good coix seed of hypoglycemic effect, Ramulus euonymi, the Radix Astragali, corn stigma and matrimony vine composition compound prescription is chosen by science, prepare each component extract, its hypoglycemic activity composition is made to obtain enrichment, the effect of its regulation and control diabetes can be strengthened, and can effectively prevent and treat and improve generation and the development of diabetic complication, be suitable for diabetes patient's long-term taking.
Detailed description of the invention
embodiment 1
There are health products for function of polysaccharide, comprise the raw material of following weight portion: Semen Coicis extract 10 parts, Ramulus euonymi extract 10 parts, astragalus polyose 8 parts, corn silk water extract 5 parts, LBP-X 3 parts.
Its preparation method is:
1. the preparation of Semen Coicis extract:
1) pulverize: the coix seed of drying pulverized and crosses 100 mesh sieves, obtaining coix seed powder;
2) first time alcohol extracting: be that the ethanolic solution of 80% is as extract using mass fraction, coix seed powder and ethanolic solution are fed intake by mass volume ratio 1:5, first coix seed powder is soaked 12 hours in ethanolic solution, extract 1 hour under 65 DEG C of conditions again, leave standstill, collecting supernatant is first time extract;
3) second time alcohol extracting: be that the ethanolic solution of 65% is as extract using mass fraction, by coix seed powder: the mass ratio of ethanol=1:5 is to step 2) in add ethanolic solution in remaining residue, extract 2 hours under 65 DEG C of conditions again, leave standstill, collect supernatant i.e. second time extract;
4) water extraction is got: by coix seed powder: the mass volume ratio of water=1:8 adds water in remaining residue in step 3), then extracts 2 hours under 100 DEG C of conditions, filters, and collects third time extract;
5) extract concentrates: by No. three extract mixing, and carry out Vacuum Concentration;
6) spraying dry: concentrate is carried out spraying dry, obtains Semen Coicis extract.
2. the preparation of Ramulus euonymi extract:
1) alcohol extract: get dry Ramulus euonymi medicinal material, using mass fraction be the ethanolic solution of 80% as extract, Ramulus euonymi and ethanolic solution are fed intake by mass volume ratio 1:6, heating and refluxing extraction 2 times, each extraction 0.5 hour, leaves standstill, and collects supernatant and ethanol extract respectively;
2) water extraction is got: by Ramulus euonymi: water=1:8 volume ratio adds water in remaining residue in step 1, then extracts 2 hours under 100 DEG C of conditions, filters, and collects aqueous extract;
5) extract concentrates: by No. three extract mixing, and carry out Vacuum Concentration;
6) spraying dry: concentrate is carried out vacuum drying, obtains Ramulus euonymi extract.
3. the preparation of astragalus polyose:
1) pulverize: the Radix Astragali pulverized and crosses 100 mesh sieves, obtaining astragalus membranaceus powder;
2) water extraction is got: by astragalus membranaceus powder: the mass ratio of water=1:10 adds water, then extracts 2 hours under 100 DEG C of conditions, filters, collects extract;
3) enzyme reaction: solution cellulase being mixed with 50 U/mL, by extract: the volume ratio of cellulase solution=5:1 adds cellulase solution, adjust ph is 5.5, and reaction temperature controls, at 30 DEG C, to react 60 min;
4) polysaccharide precipitation: by the extract after enzyme reaction process through 3000rpm high speed centrifugation 10 min, collects lower floor's polysaccharide precipitation;
5) dry: the polysaccharide precipitation obtained to be carried out spraying dry, obtains astragalus polyose.
4. the preparation of Corn silk P.E: after being cleaned by corn stigma, to add water refluxing extraction 2 times by mass volume ratio 1:2, each 30 min, collect extracted twice liquid, freeze drying obtains Corn silk P.E.
5. the preparation of LBP-X: after being cleaned by matrimony vine, to add water Microwave Extraction 2 times by mass volume ratio 1:10, extracts 20 min, microwave power 450 W at every turn, and collect extracted twice liquid, spraying dry obtains LBP-X.
6. the preparation of electuary: dried Semen Coicis extract, Ramulus euonymi extract, astragalus polyose, Corn silk P.E and LBP-X are fully mixed, adopts common process to obtain compound antihypelipidemic electuary.
embodiment 2
There are health products for function of polysaccharide, comprise the raw material of following weight portion: Semen Coicis extract 15 parts, Ramulus euonymi extract 13 parts, astragalus polyose 9 parts, corn silk water extract 6 parts, LBP-X 4 parts.
Its preparation method is:
1. the preparation of Semen Coicis extract:
1) pulverize: the coix seed of drying pulverized and crosses 100 mesh sieves, obtaining coix seed powder;
2) first time alcohol extracting: be that the ethanolic solution of 85% is as extract using mass fraction, coix seed powder and ethanolic solution are fed intake by mass volume ratio 1:6, first coix seed powder is soaked 12 hours in ethanolic solution, extract 1 hour under 65 DEG C of conditions again, leave standstill, collecting supernatant is first time extract;
3) second time alcohol extracting: be that the ethanolic solution of 65% is as extract using mass fraction, by coix seed powder: the mass ratio of ethanol=1:5 is to step 2) in add ethanolic solution in remaining residue, extract 2 hours under 65 DEG C of conditions again, leave standstill, collect supernatant i.e. second time extract;
4) water extraction is got: by coix seed powder: the mass volume ratio of water=1:8 adds water in remaining residue in step 3), then extracts 2 hours under 100 DEG C of conditions, filters, and collects third time extract;
5) extract concentrates: by No. three extract mixing, and carry out Vacuum Concentration;
6) spraying dry: concentrate is carried out spraying dry, obtains Semen Coicis extract.
2. the preparation of Ramulus euonymi extract:
1) alcohol extract: get dry Ramulus euonymi medicinal material, using mass fraction be the ethanolic solution of 87% as extract, Ramulus euonymi and ethanolic solution are fed intake by mass volume ratio 1:7, heating and refluxing extraction 2 times, each extraction 1.0 hours, leaves standstill, and collects supernatant and ethanol extract respectively;
2) water extraction is got: by Ramulus euonymi: water=1:9 volume ratio adds water in remaining residue in step 1, then extracts 2 hours under 100 DEG C of conditions, filters, and collects aqueous extract;
5) extract concentrates: by No. three extract mixing, and carry out Vacuum Concentration;
6) spraying dry: concentrate is carried out vacuum drying, obtains Ramulus euonymi extract.
3. the preparation of astragalus polyose:
1) pulverize: the Radix Astragali pulverized and crosses 100 mesh sieves, obtaining astragalus membranaceus powder;
2) water extraction is got: by astragalus membranaceus powder: the mass ratio of water=1:10 adds water, then extracts 2 hours under 100 DEG C of conditions, filters, collects extract;
3) enzyme reaction: solution cellulase being mixed with 50 U/mL, by extract: the volume ratio of cellulase solution=5:1 adds cellulase solution, adjust ph is 6.0, and reaction temperature controls, at 35 DEG C, to react 70 min;
4) polysaccharide precipitation: by the extract after enzyme reaction process through 3200rpm high speed centrifugation 10 min, collects lower floor's polysaccharide precipitation;
5) dry: the polysaccharide precipitation obtained to be carried out spraying dry, obtains astragalus polyose.
4. the preparation of Corn silk P.E: after being cleaned by corn stigma, to add water refluxing extraction 2 times by mass volume ratio 1:3, each 50 min, collect extracted twice liquid, freeze drying obtains Corn silk P.E.
5. the preparation of LBP-X: after being cleaned by matrimony vine, to add water Microwave Extraction 2 times by mass volume ratio 1:10, extracts 30 min, microwave power 470 W at every turn, and collect extracted twice liquid, spraying dry obtains LBP-X.
6. the preparation of electuary: dried Semen Coicis extract, Ramulus euonymi extract, astragalus polyose, Corn silk P.E and LBP-X are added appropriate amount of auxiliary materials, adopts common process to obtain hypoglycemic compound capsule.
embodiment 3
There are health products for function of polysaccharide, comprise the raw material of following weight portion: Semen Coicis extract 20 parts, Ramulus euonymi extract 15 parts, astragalus polyose 10 parts, corn silk water extract 8 parts, LBP-X 5 parts.
Its preparation method is:
1. the preparation of Semen Coicis extract:
1) pulverize: the coix seed of drying pulverized and crosses 100 mesh sieves, obtaining coix seed powder;
2) first time alcohol extracting: be that the ethanolic solution of 90% is as extract using mass fraction, coix seed powder and ethanolic solution are fed intake by mass volume ratio 1:6, first coix seed powder is soaked 12 hours in ethanolic solution, extract 1 hour under 65 DEG C of conditions again, leave standstill, collecting supernatant is first time extract;
3) second time alcohol extracting: be that the ethanolic solution of 65% is as extract using mass fraction, by coix seed powder: the mass ratio of ethanol=1:6 is to step 2) in add ethanolic solution in remaining residue, extract 2 hours under 65 DEG C of conditions again, leave standstill, collect supernatant i.e. second time extract;
4) water extraction is got: by coix seed powder: the mass volume ratio of water=1:8 adds water in remaining residue in step 3), then extracts 2 hours under 100 DEG C of conditions, filters, and collects third time extract;
5) extract concentrates: by No. three extract mixing, and carry out Vacuum Concentration;
6) spraying dry: concentrate is carried out spraying dry, obtains Semen Coicis extract.
2. the preparation of Ramulus euonymi extract:
1) alcohol extract: get dry Ramulus euonymi medicinal material, using mass fraction be the ethanolic solution of 90% as extract, Ramulus euonymi and ethanolic solution are fed intake by mass volume ratio 1:8, heating and refluxing extraction 2 times, each extraction 1 hour, leaves standstill, and collects supernatant and ethanol extract respectively;
2) water extraction is got: by Ramulus euonymi: water=1:10 volume ratio adds water in remaining residue in step 1, then extracts 2 hours under 100 DEG C of conditions, filters, and collects aqueous extract;
5) extract concentrates: by No. three extract mixing, and carry out Vacuum Concentration;
6) spraying dry: concentrate is carried out vacuum drying, obtains Ramulus euonymi extract.
3. the preparation of astragalus polyose:
1) pulverize: the Radix Astragali pulverized and crosses 100 mesh sieves, obtaining astragalus membranaceus powder;
2) water extraction is got: by astragalus membranaceus powder: the mass ratio of water=1:10 adds water, then extracts 2 hours under 100 DEG C of conditions, filters, collects extract;
3) enzyme reaction: solution cellulase being mixed with 50 U/mL, by extract: the volume ratio of cellulase solution=5:1 adds cellulase solution, adjust ph is 6.2, and reaction temperature controls, at 38 DEG C, to react 80 min;
4) polysaccharide precipitation: by the extract after enzyme reaction process through 3500rpm high speed centrifugation 10 min, collects lower floor's polysaccharide precipitation;
5) dry: the polysaccharide precipitation obtained to be carried out spraying dry, obtains astragalus polyose.
4. the preparation of Corn silk P.E: after being cleaned by corn stigma, to add water refluxing extraction 2 times by mass volume ratio 1:4, each 60 min, collect extracted twice liquid, freeze drying obtains Corn silk P.E.
5. the preparation of LBP-X: after being cleaned by matrimony vine, to add water Microwave Extraction 2 times by mass volume ratio 1:10, extracts 30 min, microwave power 500 W at every turn, and collect extracted twice liquid, spraying dry obtains LBP-X.
6. the preparation of electuary: dried Semen Coicis extract, Ramulus euonymi extract, astragalus polyose, Corn silk P.E and LBP-X are added appropriate amount of auxiliary materials, adopts common process to obtain compound antihypelipidemic tablet.
Model case
Example 1: patient, man, 60 years old, suffers from more than 10 years of diabetes.Dailyly control blood sugar with the medicine such as melbine, blood sugar fluctuates between 8 ~ 10mmol/L recently, and the symptoms such as conscious thirsty, sweat is many, frequent urination at night, advise that it coordinates the compound antihypelipidemic electuary taken in embodiment 1.After serveing on 7 days, the symptom such as many drinks, many food, diuresis is alleviated to some extent, and sense of fatigue alleviates; After continuing to take 20 days, the symptom such as many drinks, many food, diuresis obviously disappears, and repeatedly checks glucostasis at 6.5-7.5mmol/L; Reduced by half by Western medicine dose after taking 40 days, continue to take this compound antihypelipidemic electuary, check the ideal range of glycemic control at about 6mmol/L after 2 months, the symptom such as many drinks, many food, diuresis disappears completely simultaneously.
Example 2: patient, female, 47 years old, because body weight in 1 month declines fast, thirsty many drinks, appetite is not good enough, weakness of limbs, through the sugared 9.8mmol/L that has a blood test, its trouble diabetes B of hospital diagnosis, give glibenclamide and the treatment of Metformin Extended-release Tablets orally-taken blood sugar reducing, check after serveing on 10, blood sugar declines undesirable (9.5mmol/L), advise that the hypoglycemic compound capsule that it takes in embodiment 2 simultaneously carries out supplemental treatment, serve on 5 days, check blood sugar is 7.5mmol/L, thirsty many drinks simultaneously, appetite is not good enough and the symptom such as weakness of limbs is obviously alleviated, continue to take 20 days, thirsty many drinks, appetite is not good enough and the transference cure such as weakness of limbs, weight recovery is normal.From February, withdraw the Western medicine such as glibenclamide and Metformin Extended-release Tablets, only take this hypoglycemic compound capsule, after 1 month, check the ideal range of glycemic control at about 6mmol/L.
The foregoing is only preferred embodiment of the present invention, all equalizations done according to the present patent application the scope of the claims change and modify, and all should belong to covering scope of the present invention.
Claims (1)
1. one kind has the health products of function of polysaccharide, it is characterized in that: described health products comprise the raw material of following weight portion: Semen Coicis extract 10 ~ 20 parts, Ramulus euonymi extract 10 ~ 15 parts, astragalus polyose 8 ~ 10 parts, corn silk water extract 5 ~ 8 parts, LBP-X 3 ~ 5 parts;
The preparation method of described Semen Coicis extract comprises the following steps:
1) pulverize: the coix seed of drying pulverized and crosses 100 mesh sieves, obtaining coix seed powder;
2) first time alcohol extracting: be that the ethanolic solution of 80% ~ 90% is as extract using mass fraction, coix seed powder and ethanolic solution are fed intake by mass volume ratio 1:5 ~ 6, first coix seed powder is soaked 12 hours in ethanolic solution, extract 1 hour under 65 DEG C of conditions again, leave standstill, collecting supernatant is first time extract;
3) second time alcohol extracting: be that the ethanolic solution of 65% is as extract using mass fraction, by coix seed powder: the mass ratio of ethanol=1:5 ~ 6 is to step 2) in add ethanolic solution in remaining residue, extract 2 hours under 65 DEG C of conditions again, leave standstill, collect supernatant i.e. second time extract;
4) water extraction is got: by coix seed powder: the mass volume ratio of water=1:8 adds water in remaining residue in step 3), then extracts 2 hours under 100 DEG C of conditions, filters, and collects third time extract;
5) extract concentrates: by No. three extract mixing, and carry out Vacuum Concentration;
6) spraying dry: concentrate is carried out spraying dry, obtains Semen Coicis extract;
The preparation method of described Ramulus euonymi extract comprises the following steps:
1) alcohol extract: get dry Ramulus euonymi medicinal material, be that the ethanolic solution of 80% ~ 90% is as extract using mass fraction, Ramulus euonymi and ethanolic solution are fed intake by mass volume ratio 1:6 ~ 8, heating and refluxing extraction 2 times, each extraction 0.5 ~ 1 hour, leave standstill, collect supernatant and ethanol extract respectively;
2) water extraction is got: by Ramulus euonymi: water=1:8 ~ 10 volume ratio adds water in remaining residue in step 1, then extracts 2 hours under 100 DEG C of conditions, filters, and collects aqueous extract;
3) extract concentrates: by No. three extract mixing, and carry out Vacuum Concentration;
4) spraying dry: concentrate is carried out vacuum drying, obtains Ramulus euonymi extract;
The preparation method of described astragalus polyose comprises the following steps:
1) pulverize: the Radix Astragali pulverized and crosses 100 mesh sieves, obtaining astragalus membranaceus powder;
2) water extraction is got: by astragalus membranaceus powder: the mass ratio of water=1:10 adds water, then extracts 2 hours under 100 DEG C of conditions, filters, collects extract;
3) enzyme reaction: solution cellulase being mixed with 50 U/mL, by extract: the volume ratio of cellulase solution=5:1 adds cellulase solution, adjust ph is 5.5 ~ 6.2, and reaction temperature controls at 30 ~ 38 DEG C, reaction 60 ~ 80 min;
4) polysaccharide precipitation: by the extract after enzyme reaction process through 3000 ~ 3500rpm high speed centrifugation 10 min, collects lower floor's polysaccharide precipitation;
5) dry: the polysaccharide precipitation obtained to be carried out spraying dry, obtains astragalus polyose;
Described corn silk water extract is after being cleaned by corn stigma, to add water refluxing extraction 2 times by mass volume ratio 1:2 ~ 4, each 30 ~ 60 min, and collect extracted twice liquid, freeze drying obtains corn silk water extract;
Described LBP-X is after being cleaned by matrimony vine, and to add water Microwave Extraction 2 times by mass volume ratio 1:10, extract 20 ~ 30 min, microwave power 450 ~ 500 W, collect extracted twice liquid, spraying dry obtains LBP-X at every turn;
Dried Semen Coicis extract, Ramulus euonymi extract, astragalus polyose, Corn silk P.E and LBP-X are added auxiliary material, obtains electuary, granule, capsule or tablet with common process.
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| CN104106829A (en) * | 2014-06-10 | 2014-10-22 | 秋实草业有限公司 | Clover hypoglycemic drink |
| CN104082820A (en) * | 2014-06-10 | 2014-10-08 | 秋实草业有限公司 | Hypoglycemic soluble granules containing alfalfa |
| CN104489459A (en) * | 2014-12-04 | 2015-04-08 | 黄艳红 | Qianfo-milkvetch root polysaccharide and preparation process thereof |
| CN104922300A (en) * | 2015-06-26 | 2015-09-23 | 蔡昂迅 | Enzyme activating and regulating composition, preparation of composition, preparing method of preparation, and application of composition |
| CN105106721A (en) * | 2015-09-23 | 2015-12-02 | 洛阳华以生物工程有限公司 | Health product with efficacy of reducing blood sugar |
| CN106306908A (en) * | 2016-08-31 | 2017-01-11 | 洛阳宁竹药业有限公司 | Preparation method of antioxidant coix seed drink |
| CN107495090A (en) * | 2017-07-29 | 2017-12-22 | 贵州省华腾农业科技有限公司 | A kind of myotonin deep process |
| CN109938134A (en) * | 2019-04-11 | 2019-06-28 | 福州帅宝生物科技有限公司 | A kind of instant Semen Coicis black tea and preparation method thereof |
| CN110483658A (en) * | 2019-09-30 | 2019-11-22 | 杭州华津药业股份有限公司 | A kind of preparation method of hypoglycemic corn silk polysaccharide |
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| CN102948896A (en) * | 2011-08-30 | 2013-03-06 | 王新建 | Pearl barley blood glucose reducing beverage and preparing method thereof |
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