CN106421581A - Biological traditional Chinese medicine for oral administration for treating diabetes and preparation method thereof - Google Patents

Biological traditional Chinese medicine for oral administration for treating diabetes and preparation method thereof Download PDF

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CN106421581A
CN106421581A CN201610797847.6A CN201610797847A CN106421581A CN 106421581 A CN106421581 A CN 106421581A CN 201610797847 A CN201610797847 A CN 201610797847A CN 106421581 A CN106421581 A CN 106421581A
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medicine
thousand
enzyme
oral administration
traditional chinese
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区士衡
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Guangzhou Lsrd Biotechnology Co Ltd
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Guangzhou Lsrd Biotechnology Co Ltd
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Abstract

The invention discloses a biological traditional Chinese medicine for oral administration for treating diabetes. The biological traditional Chinese medicine for oral administration is composed of a traditional Chinese medicine part prescription and an endogenous enzyme prescription. The traditional Chinese medicine part prescription is prepared from spanishneedles herb, all grass of daun ngokilo, discolor cinquefoil herb, herba agrimoniae, American ginseng, suberect spatholobus stems, pulp of dogwood fruits, poria cocos, dried rehmannia roots, uncaria and fructus alpiniae oxyphyllae. The traditional Chinese medicine part prescription is prepared through a conventional decoction extraction method and a bio-technology enzymolysis method. Enzymes used in the bio-technology enzymolysis method are exogenous enzymes, and the exogenous enzymes are pectinase, lipase, amylase, soybean protease and cellulase. The endogenous enzyme prescription is compound pancreas islet repair enzymes, and the compound pancreas islet repair enzymes comprise kallidinogenase, trypsin, DNA polymerase, dismutase, beer enzymes and papain. The biological traditional Chinese medicine for oral administration combines the bio-technology with traditional Chinese medicine, a new thought for researching diabetes effective medicine is provided, and the biological traditional Chinese medicine for oral administration has the functions of promoting pancreas organ insulin reconstruction, reducing blood viscosity and the like.

Description

A kind of for biological Chinese herbal medicine medicine for oral administration treating diabetes and preparation method thereof
Technical field
The present invention relates to a kind of for medicine treating diabetes and preparation method thereof, be specifically related to a kind of for treating sugar Sick biological Chinese herbal medicine medicine for oral administration of urine and preparation method thereof.
Background technology
Diabetes (diabetes mellitus) be one group because insulin is absolute or relative hyposecretion and target tissue Insulin sensitivity is reduced a series of metabolic disorder syndromes such as causing protein, fat and electrolyte, wherein high blood by cell Sugar is outstanding feature.The main clinical manifestation of diabetes is many drinks, diuresis, many foods and Body weight loss (" three-many-one-little "), and Containing glucose (should not contain glucose in normal urine) etc. in blood sugar height, urine.If cannot get effectively treating, can draw Play the infringement of health multisystem；Cause various tissue, particularly eye, kidney, heart, blood vessel, neural chronic lesion, function barrier Hinder.Some patients needs life long insulin therapy.
Diabetes mellitus in China patient numbers occupy first of the whole world；According to incomplete statistics in 2015, diabetes mellitus in China patient numbers about 1 People more than hundred million, is also being continuously increased, and makes us anxious.Wherein type i diabetes accounting 5%, type ii diabetes accounting 90%, diabetes of being pregnent Accounting 4%, other diabetes accountings 1%.
Content of the invention
A kind of biology for treating diabetes is provided in place of it is an object of the invention to overcome the deficiencies in the prior art Oral medicinal herb medicine.
For achieving the above object, the technical scheme that the present invention takes is：Described biological Chinese herbal medicine medicine for oral administration is by division of traditional Chinese drugs office Square and interior kind of enzyme prescription composition, described division of traditional Chinese drugs office side comprises following to prepare raw material：Beggar-ticks, angelica keiskei koidz, potentilla discolor, red crowned crane Grass, American Ginseng, reticulate millettia, dogwood fruit, Poria cocos, divaricate gynura root and rhizome, yncaria stem with hooks and fructus alpiniae oxyphyllae；Described division of traditional Chinese drugs office side uses routine to decoct The method that extraction method combines with biotechnology enzymatic isolation method prepares；Wherein, in biotechnology enzymatic isolation method, enzyme used is outer kind of enzyme, Described outer kind of enzyme is pectase, lipase, amylase, soybean protein enzyme and cellulase；Described interior kind of enzyme prescription is compound pancreas Island repair enzyme, described compound pancreas islet repair enzyme comprise kallidinogenase, trypsase, archaeal dna polymerase, mutase, beer enzyme and Papain.
Division of traditional Chinese drugs office side of the present invention is to pathologies such as the diabetes complicated heart, the cerebrovascular, kidney, eyeground and nervous systems All having good curative effect, specifically, division of traditional Chinese drugs office Fang Fang solves as follows：
Beggar-ticks, angelica keiskei koidz, potentilla discolor, hairyvein agrimony, divaricate gynura root and rhizome, all irritate insulinoma cell proliferation, pancreas beta cell hyperplasia, The susceptibility of suppression A cells, promotes pancreas Organ Reconstruction insulin function, reduces the dependence to insulin for the diabetic；Promote Enter metabolism of blood glucose, fall end blood viscosity；Reticulate millettia, dogwood fruit, fructus alpiniae oxyphyllae, the raw marrow of benefit essence, regulate, promote big brain health. hook The formation of rattan anti-tampon to blood vessel of releiving, has positive effect at brain position especially.All medicines are to the diabetes complicated heart, brain above The pathologies such as blood vessel, kidney, eyeground and nervous system all have good curative effect.
Contain the materials such as substantial amounts of pectin, fat, starch, sugar class in the herb liquid that medicine decocting method extracts, have impact on The release of active ingredient, therefore use biology enzyme to extract again in the herb liquid that decocting for Chinese herbal medicine method is extracted and the dregs of a decoction, can be at utmost Improve the release of Effective Component of Chinese Medicine.Two methods share, higher, pure than the effective components of Chinese medicinal of any method acquisition merely.
Enzyme repaired by described interior kind of enzyme prescription, i.e. compound pancreas islet two large effects：1st, i.e. in obtaining through concentrate drying In medicament extract, add certain combination, a number of biology enzyme, composition formulation for oral administration.Treatment by Chinese herbs effect is allowed to be substantially improved； 2nd, " compound pancreas islet repairs enzyme " is to irritating, activating, and promotes pancreas Organ Reconstruction insulin function, reduces diabetic to treatment Insulin dependence, promote metabolism of blood glucose, fall end blood viscosity play a driving role.
As the preferred embodiment of the biological Chinese herbal medicine medicine for oral administration for treating diabetes of the present invention, described division of traditional Chinese drugs Office side comprises the Chinese medicine material of following weight parts：Beggar-ticks 1～10 part, angelica keiskei koidz 1～10 part, potentilla discolor 1～10 part, red crowned crane Grass 1～10 part, American Ginseng 1～10 part, reticulate millettia 1～10 part, dogwood fruit 1～10 part, 1～10 part of Poria cocos, divaricate gynura root and rhizome 1～10 Part, yncaria stem with hooks 1～10 part, fructus alpiniae oxyphyllae 1～10 part.
As the preferred embodiment of the biological Chinese herbal medicine medicine for oral administration for treating diabetes of the present invention, described interior kind of enzyme Prescription comprises the enzyme of following content：Trypsase 0.1 ten thousand-100 ц g, kallidinogenase 0.1 ten thousand-100 ц g, archaeal dna polymerase 0.1 ten thousand-100 ц g, mutase 0.1 ten thousand-100 ц g, beer enzyme 0.1 ten thousand-100 ц g, papain 0.1 ten thousand-100 ц g.
In addition, present invention also offers a kind of described for treating the preparation method of the biological Chinese herbal medicine medicine for oral administration of diabetes, Comprise the following steps：
(1) active ingredient of division of traditional Chinese drugs office side, is extracted：Chinese medicine material needed for division of traditional Chinese drugs office side is mixed in proportion, Traditional Chinese drug mixture is pressed 1 with water：20 mixing, 50-60 DEG C of low temperature extracts 2-3h, obtains middle drug filtrate, then Jiang Shui presses with middle drug filtrate 1：10 mixing, 50-60 DEG C of low temperature extracts 1-2h.
(2), biology enzyme enzymatic isolation method extracts the active ingredient of division of traditional Chinese drugs office side further：Step (1) gained Chinese medicine is filtered Liquid mixes with Chinese medicine dreg, is cooled to 30-50 DEG C, dissolves enzyme needed for outer kind of enzyme prescription by component and adds to middle drug filtrate and Chinese medicine In the mixture of the dregs of a decoction, PH be 4-6, temperature be 30-50 DEG C under conditions of, zymolyte 2-20h, filter, obtain Chinese medicine clear liquid, dry Dry to traditional Chinese medicine powder；
(3) in required ratio by the traditional Chinese medicine powder of interior kind of enzyme prescription addition step (2) gained, form various for oral administration routinely Formulation, inspection, packaging, obtain the biological Chinese herbal medicine medicine for oral administration for treating diabetes of the present invention.
Process for the preparation method of the biological Chinese herbal medicine medicine for oral administration treating diabetes of the present invention is：Screening is clear Clean Chinese medicine → pulverizing → by component allotment → conventional decoct extract twice → cool down → add biology enzyme enzymolysis and extraction → filtration → Concentration → drying → inspection → biology enzyme mixes composition formulation → inspection → bag for oral administration with the Chinese medical extract that concentrate drying obtains Dress → warehouse-in.Wherein in the preparation method of biological Chinese herbal medicine medicine for oral administration for treating diabetes of the present invention, division of traditional Chinese drugs office The active ingredient of side uses following preparation method to prepare：
(1) active ingredient of division of traditional Chinese drugs office side, is extracted：Chinese medicine material needed for division of traditional Chinese drugs office side is mixed in proportion, Traditional Chinese drug mixture is pressed 1 with water：20 mixing, 50-60 DEG C of low temperature extracts 2-3h, obtains middle drug filtrate, then Jiang Shui presses with middle drug filtrate 1：10 mixing, 50-60 DEG C of low temperature extracts 1-2h；
(2), biology enzyme enzymatic isolation method extracts the active ingredient of division of traditional Chinese drugs office side further：Step (1) gained Chinese medicine is filtered Liquid mixes with Chinese medicine dreg, is cooled to 30-50 DEG C, dissolves enzyme needed for outer kind of enzyme prescription by component and adds to middle drug filtrate and Chinese medicine In the mixture of the dregs of a decoction, PH be 4-6, temperature be 30-50 DEG C under conditions of, zymolyte 2-20h, filter, obtain Chinese medicine clear liquid, dry Dry to traditional Chinese medicine powder.
As the preferred embodiment of the preparation method of the biological Chinese herbal medicine medicine for oral administration for treating diabetes of the present invention, In described step (1), division of traditional Chinese drugs office side comprises the Chinese medicine material of following weight parts：Beggar-ticks 1～10 part, angelica keiskei koidz 1～10 Part, potentilla discolor 1～10 part, hairyvein agrimony 1～10 part, American Ginseng 1～10 part, reticulate millettia 1～10 part, dogwood fruit 1～10 part, Poria cocos 1～10 part, divaricate gynura root and rhizome 1～10 part, yncaria stem with hooks 1～10 part, fructus alpiniae oxyphyllae 1～10 part.As of the present invention for treating diabetes The preferred embodiment of preparation method of biological Chinese herbal medicine medicine for oral administration, it is pectase, fat that enzyme prescription is planted by described step (2) China and foreign countries Enzyme, amylase, soybean protein enzyme, cellulase.Described outer kind of enzyme prescription, can effectively digest pectin, fat, starch, sugar class Deng material so that Effective Component of Chinese Medicine at utmost discharges and obtains.
As the preferred embodiment of the preparation method of the biological Chinese herbal medicine medicine for oral administration for treating diabetes of the present invention, Interior kind of enzyme prescription described in described step (3) comprises the enzyme of following content：Trypsase 0.1 ten thousand-100 ц g, kallidinogenase 0.1 ten thousand-100 ц g, archaeal dna polymerase 0.1 ten thousand-100 ц g, mutase 0.1 ten thousand-100 ц g, beer enzyme 0.1 ten thousand-100 ц g, Papain 0.1 ten thousand-100 ц g.
As the preferred embodiment of the preparation method of the biological Chinese herbal medicine medicine for oral administration for treating diabetes of the present invention, In described outer kind of enzyme prescription, enzyme unit and the deal of enzyme used are：Pectase 0.1 ten thousand-100 ц g, 1-10 part；Lipase 0.11 Ten thousand-100 ten thousand ц g, 1-10 part, amylase 0.1 ten thousand-100 ten thousand ц g, 1-10 part, soybean protein enzyme 0.1 ten thousand-100 ten thousand ц g, 1-10 Part, cellulase 0.1 ten thousand-100 ten thousand ц g, 1-10 part.
As the preferred embodiment of the preparation method of the biological Chinese herbal medicine medicine for oral administration for treating diabetes of the present invention, Step (1a) is also included before described step (1)：The Chinese medicine material of each division of traditional Chinese drugs office side is pulverized.Raw material is pulverized, favorably In the active principle extracting in raw material.
As the preferred embodiment of the preparation method of the biological Chinese herbal medicine medicine for oral administration for treating diabetes of the present invention, It is crushed to 60-120 mesh after Chinese medicine clear liquid is dried to powder by described step (2).
As the preferred embodiment of the preparation method of the biological Chinese herbal medicine medicine for oral administration for treating diabetes of the present invention, Described step (3) can be prepared as various dosage formulation for oral administration after mixing interior kind of enzyme prescription and traditional Chinese medicine powder in proportion.
In addition, the open a kind of pharmaceutical composition of the present invention, described pharmaceutical composition comprises any one of Claims 1 to 4 institute State the biological Chinese herbal medicine medicine for oral administration for treating diabetes and the excipient pharmaceutically accepting or carrier.
As the preferred embodiment of pharmaceutical composition of the present invention, the described excipient pharmaceutically accepting or carrier For water, starch, wine, capsule shells etc..
As the preferred embodiment of pharmaceutical composition of the present invention, the formulation of described pharmaceutical composition is capsule, piece Agent, pulvis, pill or oral liquid etc..
Compared with prior art, beneficial effects of the present invention is：First, biological Chinese herbal medicine medicine for oral administration of the present invention uses raw Thing technology combines with traditional Chinese medicine, plants enzyme prescription in traditional Chinese medicine composition in adding, it is proposed that sugar is cured in research, a creation The sick effective medicine of urine and New methods in working；Secondly, traditional Chinese medicine ingredients of the present invention can treat diabetes, and it has Following characteristics：1st, irritate, promote pancreas Organ Reconstruction insulin function, reduce diabetic to medicine insulin depend on Rely；2nd, metabolism of blood glucose, fall end blood viscosity are promoted；Promote kidney, brain health { kidney production of sperm benefit marrow }:Adjust cerebral nerve, balance Pituitary hormone secretion, the diastole cerebrovascular.By regulation cerebral function, highly effective to promotion insulin power of regeneration.Through facing Bed checking, Chinese medical extract and the efficient of medicine composite for curing diabetes containing this Chinese medical extract of the present invention reach 100%, to type II diabetes, curative effect at a specified future date reaches more than 90%.
In addition, the preparation method of the biological Chinese herbal medicine medicine for oral administration for treating diabetes of the present invention, its comprehensive use is often Rule decocting method extracts the active principle in Chinese medicine with biotechnology enzymatic isolation method, so can improve releasing of Effective Component of Chinese Medicine Putting, the effective components of Chinese medicinal of acquisition is higher, purer.
The preparation method of Chinese medical extract of the present invention is by the effective elements of the medicine ratio in biology enzyme, the extracted substrate of enzymolysis Traditional extraction exceeds the 4th, five times of content, and being absorbed by the body to greatest extent for medicine, it is possible to provide, and the enzyme in pharmaceutical composition The active ingredient of plurality of Chinese is digested in intestines and stomach, fuses, is transformed into many points more and closes (polymolecular, many materials combine) plant " the dimension acid of class paddy ", completes material from amount to the change of matter, at this time treats the Effective Component of Chinese Medicine of diabetes, digested Being transformed into the active principle of " nanoscale ", can be absorbed by the body offer to greatest extent for medicine may.
Detailed description of the invention
For the object, technical solutions and advantages of the present invention are better described, below in conjunction with specific embodiment to the present invention It is described further.
Biological Chinese herbal medicine medicine for oral administration for treating diabetes of the present invention can be made into various treatment diabetes biological Chinese herbal medicine Formulation, " the comprehensive summary of clinical case " in following example uses biological Chinese herbal medicine medicine for oral administration prescription of the present invention, system What Preparation Method was fabricated to controls diabetes " biological Chinese herbal medicine capsule ".
Embodiment 1
A kind of embodiment of the biological Chinese herbal medicine medicine for oral administration for treating diabetes of the present invention, biological described in the present embodiment The raw material of preparing of oral medicinal herb medicine is：Division of traditional Chinese drugs office is divided：Beggar-ticks 1 part, angelica keiskei koidz 10 parts, potentilla discolor 10 parts, hairyvein agrimony 10 Part, American Ginseng 1 part, reticulate millettia 10 parts, dogwood fruit 1 part, 1 part of Poria cocos, divaricate gynura root and rhizome 1 part, yncaria stem with hooks 10 parts, fructus alpiniae oxyphyllae 10 parts；Outer kind Enzyme prescription：Pectase 0.1 ten thousand-100 ц g, 1 part, lipase 0.11 ten thousand-100 ten thousand ц g, 10 parts, amylase 0.1 ten thousand-100 ten thousand ц g, 10 parts, soybean protein 0.1 ten thousand-100 ten thousand ц g, 10 parts, cellulase 0.1 ten thousand-100 ten thousand ц g, 1 part；Interior kind of enzyme prescription： Trypsase 0.1 ten thousand-100 ц g, kallidinogenase 0.1 ten thousand-100 ц g, archaeal dna polymerase 0.1 ten thousand-100 ц g, mutase 0.1 ten thousand-100 ц g, beer enzyme 0.1 ten thousand-100 ц g, papain 0.1 ten thousand-100 ц g.Wherein, described part is weight portion.
Described in the present embodiment, the preparation method of the biological Chinese herbal medicine medicine for oral administration for treating diabetes is：
(1) raw material prepared by screening cleaning Chinese medicine, and is all crushed to 20 mesh by preparing raw material；(2), low temperature extracts Chinese medicine part The active ingredient of prescription：Chinese medicine material needed for division of traditional Chinese drugs office side is mixed in proportion, Traditional Chinese drug mixture is pressed 1 with water：20 mix Closing, 50-60 DEG C of low temperature extracts 2h, obtains middle drug filtrate, then Jiang Shui presses 1 with middle drug filtrate：10 mixing, 50-60 DEG C of low temperature extracts 1h.
(3), biology enzyme enzymatic isolation method extracts the active ingredient of division of traditional Chinese drugs office side further：Step (1) gained Chinese medicine is filtered Liquid mixes with Chinese medicine dreg, is cooled to 30-50 DEG C, dissolves enzyme needed for outer kind of enzyme prescription by component and adds to middle drug filtrate and Chinese medicine In the mixture of the dregs of a decoction, PH be 4-6, temperature be 30-50 DEG C under conditions of, zymolyte 2-20h, filter, obtain Chinese medicine clear liquid, dry Dry to traditional Chinese medicine powder；
(4) in required ratio by the traditional Chinese medicine powder of interior kind of enzyme prescription addition step (2) gained, form various for oral administration routinely Formulation, inspection, packaging, obtain the biological Chinese herbal medicine medicine for oral administration for treating diabetes of the present invention.
Embodiment 2
A kind of embodiment of the biological Chinese herbal medicine medicine for oral administration for treating diabetes of the present invention, biological described in the present embodiment The raw material of preparing of oral medicinal herb medicine is：Division of traditional Chinese drugs office is divided：Beggar-ticks 10 parts, angelica keiskei koidz 1 part, potentilla discolor 1 part, hairyvein agrimony 1 part, American Ginseng 10 parts, reticulate millettia 1 part, dogwood fruit 10 parts, 10 parts of Poria cocos, divaricate gynura root and rhizome 10 parts, yncaria stem with hooks 1 part, fructus alpiniae oxyphyllae 1 part；Outer kind of enzyme Prescription：Pectase 0.1 ten thousand-100 ц g, 10 parts, lipase 0.11 ten thousand-100 ten thousand ц g, 1 part, amylase 0.1 ten thousand-100 ten thousand ц G, 1 part, soybean protein enzyme 0.1 ten thousand-100 ten thousand ц g, 1 part, cellulase 0.1 ten thousand-100 ten thousand ц g, 10 parts；Interior kind of enzyme prescription： Trypsase 0.1 ten thousand-100 ц g, kallidinogenase 0.1 ten thousand-100 ц g, archaeal dna polymerase 0.1 ten thousand-100 ц g, mutase 0.1 ten thousand-100 ц g, beer enzyme 0.1 ten thousand-100 ц g, papain 0.1 ten thousand-100 ц g.Wherein, described part is weight portion.
It is used for described in the present embodiment treating the preparation method of the biological Chinese herbal medicine medicine for oral administration of diabetes with embodiment 1.
Embodiment 3
A kind of embodiment of the biological Chinese herbal medicine medicine for oral administration for treating diabetes of the present invention, biological described in the present embodiment The raw material of preparing of oral medicinal herb medicine is：Division of traditional Chinese drugs office is divided：Beggar-ticks 5 parts, angelica keiskei koidz 8 parts, potentilla discolor 9 parts, hairyvein agrimony 6 parts, American Ginseng 5 parts, reticulate millettia 7 parts, dogwood fruit 9 parts, 8 parts of Poria cocos, divaricate gynura root and rhizome 8 parts, yncaria stem with hooks 9 parts, fructus alpiniae oxyphyllae 8 parts；Outer kind of enzyme prescription： Pectase 0.1 ten thousand-100 ц g, 4 parts, lipase 0.11 ten thousand-100 ten thousand ц g, 5 parts, amylase 0.1 ten thousand-100 ten thousand ц g, 6 parts, Soybean protein enzyme 0.1 ten thousand-100 ten thousand ц g, 4 parts, cellulase 0.1 ten thousand-100 ten thousand ц g, 8 parts；Interior kind of enzyme prescription：Trypsase 0.1 ten thousand-100 ц g, kallidinogenase 0.1 ten thousand-100 ц g, archaeal dna polymerase 0.1 ten thousand-100 ц g, mutase 0.1 ten thousand-100 ц g, beer enzyme 0.1 ten thousand-100 ц g, papain 0.1 ten thousand-100 ц g.Wherein, described part is weight portion.
It is used for described in the present embodiment treating the preparation method of the biological Chinese herbal medicine medicine for oral administration of diabetes with embodiment 1.
Embodiment 4
A kind of embodiment of pharmaceutical composition of the present invention, pharmaceutical composition described in the present embodiment comprises described for controlling Treat the biological Chinese herbal medicine medicine for oral administration of diabetes and the excipient pharmaceutically accepting or carrier.The preparation of described biological Chinese herbal medicine medicine for oral administration Raw material is：Division of traditional Chinese drugs office is divided：Beggar-ticks 7 parts, angelica keiskei koidz 9 parts, potentilla discolor 8 parts, hairyvein agrimony 9 parts, American Ginseng 8 parts, reticulate millettia 6 Part, dogwood fruit 7 parts, 6 parts of Poria cocos, divaricate gynura root and rhizome 8 parts, yncaria stem with hooks 7 parts, fructus alpiniae oxyphyllae 8 parts；Outer kind of enzyme prescription：Pectase 0.1 ten thousand-100 ц g, 4 parts, lipase 0.11 ten thousand-100 ten thousand ц g, 5 parts, amylase 0.1 ten thousand-100 ten thousand ц g, 6 parts, soybean protein enzyme 0.1 Ten thousand-100 ten thousand ц g, 5 parts, cellulase 0.1 ten thousand-100 ten thousand ц g, 9 parts；Interior kind of enzyme prescription：Trypsase 0.1 ten thousand-100 ц G, kallidinogenase 0.1 ten thousand-100 ц g, archaeal dna polymerase 0.1 ten thousand-100 ц g, mutase 0.1 ten thousand-100 ц g, beer enzyme 0.1 ten thousand-100 ц g, papain 0.1 ten thousand-100 ц g.Wherein, described part is weight portion.The described load pharmaceutically accepting Body is capsule shells.
It is used for described in the present embodiment treating the preparation method of the biological Chinese herbal medicine medicine for oral administration of diabetes with embodiment 1.Then adopt With conventional production process, pharmaceutical composition of the present invention is prepared as biological Chinese herbal medicine capsule formulation.
Embodiment 5
We are used for the biological Chinese herbal medicine medicine for oral administration being used for treating diabetes of the present invention in clinic, have investigated its effect. Concrete investigation mode and investigation result are as follows：
According to new diagnostic criteria 1999WHO of diabetes, and 2002《Traditional Chinese medical science Clinical Researches of New Drugs guideline》Middle institute The disease of row symptom and predominantly detect listed symptom in index, curative effect determinate standard, and diabetic symptom grading scale, and warp Clinical data judges to meet the Ith, type II diabetes diagnosis, and conclusion is summarized as follows：
1.1st, clinical time：2009-2014；
1.2nd, diabetes clinical case data 150 case, has family diabetic history person 15 case；
1.3rd, by diabetes character row：
Type 1 diabetes patient 15 case, accounts for 10%；
Diabetes B patient 135 case, accounts for 90%；
The person's example that has diabetic complication, accounts for 60%；In complication, the several complication of some patients has concurrently simultaneously；
1.4th, by diabetes sick time row：
The shortest person of the course of disease 9 months；
Course of disease elder 36 years；
1.5th, arrange by diabetic's age：
16-68 year is wherein：
16 25 years old 5 cases；Account for 3%；
26 40 years old 38 cases；Account for 25%；
41 55 years old 63 cases；Account for 42%；
Within 56 years old, more than 60 years old 45 cases account for 30%；
1.6th, medicine for treatment：Orally taken for curing diabetes " biological Chinese herbal medicine capsule "；
1.7th, consumption and usage：Every day 46, early, the noon, one after each meal in evening, 23 for oral administration；
1.8th, treatment time：60 days [course for the treatment of]；
1.9th, medication principle of reatment：
To the diabetic using medicine insulin or other antidiabetic drugs, taking treatment diabetes " biological Chinese herbal medicine glue Capsule " is simultaneously, it is impossible to stop taking of medicine insulin or other hypoglycemic medicines at once, and reason is that health and the course of disease are to new medicine There is a buffering reception process, it is necessary to substitute in proper order according to the state of an illness, to treatment diabetes " biological Chinese herbal medicine capsule " onset, control it The course of disease, can cut out other medicine.For being just found to have II diabetic symptom, high blood glucose paradiabetes patient, directly Connect and take treatment diabetes " biological Chinese herbal medicine capsule ".This medicine can also be used for the generation of health care prevention diabetes；
1.10, result for the treatment of：
Now extract five model case introductions：
【Clinical case 1】
【Name】Chen Sheng【Sex】Man【Age】50 years old
【Medical history】5 years
【Symptom】Diabetic
【Medicine for treatment】For oral administration "《Specially for treating diabetes biological Chinese herbal medicine capsule》, 2 tablets/time, 2 times/day
【Symptom】
Diabetic is old be born in 5 years before suffer from diabetes, once sought medical advice in Hospitals in Guangdong Province many places, medical effect is repeatedly Multiple, during blood sugar during height at the bottom of, first visit was on June 19th, 2009, after testing：Fasting blood-glucose 16.45mmol/L, Urine proteins +++, saccharification Blood sugar 12.30mmol/L.Clinical symptoms：Often dizzy, forgetful, dysphoria, depressed emotion.Bitter taste, dry throat, urine is partially yellow, greatly Just often constipated, more than three, symptom is inconspicuous, physique puffiness, and often sense is weak.Small and wiry pulse, tongue nature is partially red, and the tongue heart is slightly yellow, and complexion is dark Stagnant.Examine as yin asthenia generating intrinsic heat, stagnation of liver qi, damage of kidney-essence, amasss year in and year out to bend and forms diabetes.
Take "《Specially for treating diabetes biological Chinese herbal medicine capsule》" after 10 days, disable orally-taken blood sugar reducing medicine.After 30 days, after testing, Urine proteins, blood sugar, recovery are normal.Continue to keep conventional dose, after the course for the treatment of, drug withdrawal.Paying a return visit after 2 years, each laboratory indexes is just Often.
【Clinical case 2】
【Name】Mrs Li【Sex】Female【Age】55 years old
【Medical history】24 years
【Symptom】Diabetes are held concurrently renal dysfunction【Ephrosis】
【Medicine for treatment】For oral administration《Specially for treating diabetes biological Chinese herbal medicine capsule》3 tablets/time, 2 times/day
【Symptom】
On March 5th, 2010 goes to a doctor：Puffiness of face, double lower limb slighter compress finger marks are obvious, and dry is thirsty, and drink is few, and night urinates Frequently, face is dark, dizzy, tinnitus, and eye is fine dry and astringent, weak, soreness and weakness of waist and knees, and loose stool amount is few, and tongue nature is dull, and sublingual vein has pelidnoma Point, tongue is greasy in vain, and forceless deep pulse is carefully puckery.Fasting blood-glucose 12.83mmol/L, Urine proteins +++, blood urea nitrogen 24mg%, creatinine 1mg%, Blood pressure 165/90mmHg, dialectical for the insufficiency of both the spleen and the kindey, retention of water-damp in the body, stagnation of blood stasis belongs to diabetogenous nephrosis hypofunction and the oedema that arrives.
Take《Specially for treating diabetes biological Chinese herbal medicine capsule》After 10 days, blood sugar is basicly stable, and each symptom mitigates.Minimizing prodrug, Until disabling other hypoglycemic medicines.For oral administration《Specially for treating diabetes biological Chinese herbal medicine capsule》After 60 days, edema, other transference cures, kidney Function be improved significantly, stable disease.After testing, Urine proteins, blood sugar, recovery are normal.Continue to keep conventional dose one course for the treatment of. In June, 2011 pays a return visit, and the state of an illness does not occur repeatedly, and laboratory indexes is normal, feels good.
【Clinical case 3】
【Name】Huang Sheng【Sex】Man【Age】61 years old
【Medical history】13 years
【Symptom】Diabetes complicated coronary heart disease, high blood pressure
【Medicine】For oral administration《Specially for treating diabetes biological Chinese herbal medicine capsule》2 tablets/time, 3 times/day
【Symptom】
Patient goes to a doctor in August, 2009.There is diabetic history 13 years, based on daily OHA.Look into case history summary：Before half a year Become thin weak increasing the weight of, and with palpitaition, dizziness, god's discomfort tired, uncomfortable in chest, acupuncture sample pectoralgia battle array is made, and dry is intended to drink, dry and hard excrement, and tongue is dark Red have petechia, and the thin few Tianjin of tongue, corpulent tongue, limit print with teeth, sublingual vein is livid purple, and deep thready pulse is puckery unable.Electrocardio illustrates coronary artery Blood supply insufficiency, is diagnosed as coronary heart disease, high blood pressure (II phase).Adding the medicines such as cardiovascular and cerebrovascular so far, effect is not notable.Change Test：Fasting blood 13.8mmol/L, glucose in urine (+++), urine ketoboidies (++) trigalloyl glycosides oil 2.5mmol/L, cholesterol 6.9mmol/L, fat Albumen (a) 480mg/L, plasma viscosity 2.18mpas.Blood pressure 24/13.5KPa.
For oral administration《Specially for treating diabetes biological Chinese herbal medicine capsule》, after 10 days, each symptom mitigates, and reduces prodrug until disabling other Hypoglycemic medicine.After 60 days, check：Electrocardiogram myocardial ischemia symptom substantially disappears, fasting blood-glucose 6.8mmol/L, and blood fat, blood plasma stick Degree index is normal, and complication is inconspicuous, and blood sugar is controlled.Add course for the treatment of after treatment.Pay a return visit after 1 year, have no above-mentioned all Disease occurs.
【Clinical case 4】
【Name】Deng Sheng【Sex】Man【Age】58 years old
【Medical history】8 years
【Symptom】Diabetes merge cerebrovascular sclerosis, the retinitis,
【Medicine for treatment】For oral administration《Specially for treating diabetes biological Chinese herbal medicine capsule》2 tablets/time, 3 times/day
【Symptom】
On March 15th, 2012 patient assessment, readme：In August, 2011 feels that Light-headedness, eyesight are not stuck with paste, palpitaition asthma, day Increase the weight of temporarily.Guangzhou Grade A hospital is diagnosed as diabetes complicated cerebrovascular sclerosis, the retinitis, was once in hospital, and leaves hospital after releiving, Again and again, being much troubled all day, Bp8.5/4KPa, ECG show heart blood supply insufficiency, fasting blood-glucose 14.5mmol/L, Urine proteins (++ ++),
For oral administration《Specially for treating diabetes biological Chinese herbal medicine capsule》After 10 days, reduce prodrug until only taking《Specially for treating diabetes is biological Chinese medicinal capsule》One course for the treatment of, the transference cure such as have a dizzy spell, double thready and moderate pulses are strong, and eyesight is obviously improved.Look into fasting blood-glucose, urine egg Bai Jun is down to normally.Add course for the treatment of after treatment.In August, 2013 pays a return visit, and has no that above-mentioned all diseases occur.
【Clinical case 5】
【Name】Mrs Zeng
【Sex】Female
【Age】52 years old
【Medical history】10 years
【Consultation time】On April 5th, 2012
【Symptom】Diabetes complicated PVR, heart disease, kidney trouble, peripheral neuropathy
【Medicine for treatment】For oral administration《Specially for treating diabetes biological Chinese herbal medicine capsule》2 tablets/time, 3 times/day
【Symptom】
First, patient assessment's on April 5th, 2012, examines and sees：Face is floating, edema of limbs, sallow complexion are wan and sallow, faint low voice, the vexed heart Throbbing with fear, losing heart and seemingly breathe heavily, front severe pain, less bedroom dreaminess, night sweat, dysphoria in chestpalms-soles, thirsty drink is immoderate, and frequent urination is anxious swollen, muddy dirty smelly, has Foam oil slick sample thing, oral lesions, mouth general saliva phlegm, mouth dirty spray people, bleeding from the gum nosebleed epistaxis, finger-joint and knee ankle-joint pain numbness, Stomachache apocleisis, the dry and astringent discomfort of eyes, blurred vision, eyesight significantly goes down, and tongue is dry without tongue, thready rapid pulse and puckery.Look into：Fasting blood-glucose 20.5mmol/l, glucose in urine ++++, Urine proteins +++, urine ketoboidies-, erythrocyte sedimentation rate 23mm/h.Electrocardiogram：ST-T changes.ENT dept.'s eyeground inspection Look into：PVR II phase, with a little remote hemorrhage, phlebectasia.Examine as diabetes complicated property PVR, glycosuria Characteristic of disease heart disease, diabetic nephropathy, diabetic peripheral neuropathy.
【Medicine for treatment】Before patient assessment institute, medicine used is constant, adds for oral administration《Specially for treating diabetes biological Chinese herbal medicine capsule》, 15 After it, reduce prodrug until only taking《Specially for treating diabetes biological Chinese herbal medicine capsule》One course for the treatment of, above-mentioned symptom takes a turn for the better substantially, adds one The after treatment course for the treatment of.In August, 2013 pays a return visit, and has no that above-mentioned all diseases occur.Look into fasting blood-glucose, Urine proteins to be all down to normally.
As can be seen from the above results, the biological Chinese herbal medicine medicine for oral administration for treating diabetes of the present invention has and well controls Therapeutic effect, carries out curative effect of medication fractionation to it, and the feature of its maximum is：1st, irritate, promote pancreas Organ Reconstruction insulin function, Reduce diabetic to medicine insulin dependence；2nd, metabolism of blood glucose, fall end blood viscosity are promoted；3rd, kidney, brain are promoted Healthy { kidney production of sperm benefit marrow }:Adjust cerebral nerve, balance pituitary hormone secretion, the diastole cerebrovascular. by regulation cerebral function, Highly effective to promotion insulin power of regeneration.
Any medicine, no matter how to suit the medicine to the illness, effect how magical, good medical effect to be produced and must possess two bars Part；1st, enough doses；2nd, it is absorbed by the body to greatest extent.Biotechnology is by outer kind of biology enzyme, enzymolysis and extraction substrate Chinese medicine Active ingredient exceed the 4th, five times of content than traditional extraction, this relatively meets first condition, and for medicine to greatest extent It is absorbed by the body and create possibility.And interior kind of biology enzyme digests the active ingredient of plurality of Chinese in intestines and stomach, fuses, changes The many conjunctions of Cheng Duofen (polymolecular, many materials combine) plant " the dimension acid of class paddy ", becomes wine as rice, completes material from amount to matter Change, at this time treat diabetes " biological Chinese herbal medicine capsule " Effective Component of Chinese Medicine, be transformed into " nanoscale " by enzymolysis Active principle, can " be absorbed by the body to greatest extent ".And the complication that diabetes are brought, its root in diabetes, " skin it Do not deposit, hair here attached ".As long as having cured diabetes clinically, just alleviating for other complication or entirely healing, creating very well Physiological condition.The still more medicine of prescription is also very notable to the curative effect of this kind of complication.
Last institute is it should be noted that, the present invention is only protected by above example in order to technical scheme to be described Protecting the restriction of scope, although being explained in detail the present invention with reference to preferred embodiment, those of ordinary skill in the art should Understand, technical scheme can be modified or equivalent, without deviating from the essence of technical solution of the present invention And scope.

Claims (10)

1. the biological Chinese herbal medicine medicine for oral administration being used for treating diabetes, it is characterised in that described biological Chinese herbal medicine medicine for oral administration is by Chinese medicine Part prescription and interior kind of enzyme prescription composition, described division of traditional Chinese drugs office side comprises following to prepare raw material：Beggar-ticks, angelica keiskei koidz, turn over white Grass, hairyvein agrimony, American Ginseng, reticulate millettia, dogwood fruit, Poria cocos, divaricate gynura root and rhizome, yncaria stem with hooks and fructus alpiniae oxyphyllae；
The method that described division of traditional Chinese drugs office side uses routine decoction extraction method to combine with biotechnology enzymatic isolation method prepares；Wherein, Enzyme used in biotechnology enzymatic isolation method is outer kind of enzyme, and described outer kind of enzyme is pectase, lipase, amylase, soybean protein enzyme And cellulase；
Described interior kind of enzyme prescription be compound pancreas islet repair enzyme, described compound pancreas islet repair enzyme comprise kallidinogenase, trypsase, Archaeal dna polymerase, mutase, beer enzyme and papain.
2. as claimed in claim 1 for treating the biological Chinese herbal medicine medicine for oral administration of diabetes, it is characterised in that described division of traditional Chinese drugs office Side comprises the Chinese medicine material of following weight parts：Beggar-ticks 1～10 part, angelica keiskei koidz 1～10 part, potentilla discolor 1～10 part, hairyvein agrimony 1 ～10 parts, American Ginseng 1～10 part, reticulate millettia 1～10 part, dogwood fruit 1～10 part, 1～10 part of Poria cocos, divaricate gynura root and rhizome 1～10 part, hook 1～10 part of rattan, fructus alpiniae oxyphyllae 1～10 part.
3. as claimed in claim 1 for treating the biological Chinese herbal medicine medicine for oral administration of diabetes, it is characterised in that described interior kind of enzyme prescription Comprise the enzyme of following content：Trypsase 0.1 ten thousand-100 ц g, kallidinogenase 0.1 ten thousand-100 ц g, archaeal dna polymerase 0.1 Ten thousand-100 ц g, mutase 0.1 ten thousand-100 ц g, beer enzyme 0.1 ten thousand-100 ц g, papain 0.1 ten thousand-100 ц g.
4. as claimed in claim 1 for treating the biological Chinese herbal medicine medicine for oral administration of diabetes, it is characterised in that described outer kind of enzyme prescription In the enzyme unit of enzyme used and deal be：Pectase 0.1 ten thousand-100 ц g, 1-10 part；Lipase 0.11 ten thousand-100 ten thousand ц g, 1- 10 parts, amylase 0.1 ten thousand-100 ten thousand ц g, 1-10 part, soybean protein enzyme 0.1 ten thousand-100 ten thousand ц g, 1-10 part, cellulase 0.1 Ten thousand-100 ten thousand ц g, 1-10 part.
5. for treating a preparation method for the biological Chinese herbal medicine medicine for oral administration of diabetes as described in any one of Claims 1 to 4, its It is characterised by, comprise the following steps：
(1) active ingredient of division of traditional Chinese drugs office side, is extracted：Chinese medicine material needed for division of traditional Chinese drugs office side is mixed in proportion, in inciting somebody to action Medicine mixture presses 1 with water：20 mixing, 50-60 DEG C is extracted 2-3h, obtains middle drug filtrate, then Jiang Shui presses 1 with middle drug filtrate：10 mixing, 50-60 DEG C of low temperature extracts 1-2h；
(2), biology enzyme enzymatic isolation method extracts the active ingredient of division of traditional Chinese drugs office side further：By drug filtrate in step (1) gained with Chinese medicine dreg mixes, and is cooled to 30-50 DEG C, dissolves enzyme needed for outer kind of enzyme prescription by component and adds to middle drug filtrate and Chinese medicine dreg Mixture in, PH be 4-6, temperature be 30-50 DEG C under conditions of, zymolyte 2-20h, filter, obtain Chinese medicine clear liquid, be dried extremely Traditional Chinese medicine powder；
(3) in required ratio by the traditional Chinese medicine powder of interior kind of enzyme prescription addition step (2) gained, various Oral preparation is formed routinely Type, inspection, packaging, obtain the biological Chinese herbal medicine medicine for oral administration for treating diabetes of the present invention.
6. as claimed in claim 5 for treating the preparation method of the biological Chinese herbal medicine medicine for oral administration of diabetes, it is characterised in that described Step (1a) is also included before step (1)：The Chinese medicine material of each division of traditional Chinese drugs office side is pulverized.
7. as claimed in claim 5 for treating the preparation method of the biological Chinese herbal medicine medicine for oral administration of diabetes, it is characterised in that described It is crushed to 60-120 mesh after Chinese medicine clear liquid is dried to powder by step (2).
8. a pharmaceutical composition, comprises described in any one of Claims 1 to 4 for treating the biological Chinese herbal medicine medicine for oral administration of diabetes The excipient pharmaceutically accepting or carrier.
9. pharmaceutical composition as claimed in claim 8, it is characterised in that the described excipient pharmaceutically accepting or carrier are Water, starch, wine, capsule shells.
10. pharmaceutical composition as claimed in claim 8 or 9, it is characterised in that the formulation of described pharmaceutical composition be capsule, The preparation types such as tablet, pulvis, pill, vina, oral liquid.
CN201610797847.6A 2016-08-31 2016-08-31 Biological traditional Chinese medicine for oral administration for treating diabetes and preparation method thereof Pending CN106421581A (en)

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107446773A (en) * 2017-08-22 2017-12-08 贵州布医坊民族特色用品有限公司 A kind of functional form tea wine and preparation method thereof
CN110772630A (en) * 2019-10-25 2020-02-11 运鸿集团股份有限公司 Compound bitter gourd peptide oral liquid for activating insulin receptor and regulating blood sugar and preparation method thereof
CN111821402A (en) * 2020-07-30 2020-10-27 海南医学院 Traditional Chinese medicine composition for treating diabetic nephropathy and preparation method thereof

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104001003A (en) * 2014-04-15 2014-08-27 吕士敏 Oral liquid and sublingual spraying agent for treating diabetes
CN104056240A (en) * 2014-07-10 2014-09-24 崇州市地龙海龙生物制品开发研究所 Preparation method of preparation for treating diabetes

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104001003A (en) * 2014-04-15 2014-08-27 吕士敏 Oral liquid and sublingual spraying agent for treating diabetes
CN104056240A (en) * 2014-07-10 2014-09-24 崇州市地龙海龙生物制品开发研究所 Preparation method of preparation for treating diabetes

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107446773A (en) * 2017-08-22 2017-12-08 贵州布医坊民族特色用品有限公司 A kind of functional form tea wine and preparation method thereof
CN110772630A (en) * 2019-10-25 2020-02-11 运鸿集团股份有限公司 Compound bitter gourd peptide oral liquid for activating insulin receptor and regulating blood sugar and preparation method thereof
CN111821402A (en) * 2020-07-30 2020-10-27 海南医学院 Traditional Chinese medicine composition for treating diabetic nephropathy and preparation method thereof
CN111821402B (en) * 2020-07-30 2022-03-01 海南医学院 Traditional Chinese medicine composition for treating diabetic nephropathy and preparation method thereof

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